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Aliases for GPATCH11 Gene

Aliases for GPATCH11 Gene

  • G-Patch Domain Containing 11 2 3 5
  • Coiled-Coil Domain-Containing Protein 75 3 4
  • Coiled-Coil Domain Containing 75 2 3
  • Centromere Protein Y 2 3
  • CCDC75 3 4
  • CENP-Y 3 4
  • G Patch Domain-Containing Protein 11 3
  • CENPY 3

External Ids for GPATCH11 Gene

Previous HGNC Symbols for GPATCH11 Gene

  • CCDC75

Previous GeneCards Identifiers for GPATCH11 Gene

  • GC02P037314

Summaries for GPATCH11 Gene

GeneCards Summary for GPATCH11 Gene

GPATCH11 (G-Patch Domain Containing 11) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPATCH11 Gene

Genomics for GPATCH11 Gene

Regulatory Elements for GPATCH11 Gene

Enhancers for GPATCH11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G037079 1.1 Ensembl ENCODE dbSUPER 12.5 -3.8 -3787 2.6 HDAC1 KLF1 RFX1 PKNOX1 ZNF10 TBX21 ZBTB17 SPI1 GPATCH11 CEBPZOS HEATR5B GC02M036982
GH02G037098 1 ENCODE 11.7 +14.4 14420 1.7 ATF1 FOXA2 PKNOX1 CREB3L1 AGO1 SIN3A ZNF2 YY1 GLIS2 ZNF143 GPATCH11 EIF2AK2 HEATR5B CEBPZOS ENSG00000224891
GH02G037062 0.4 dbSUPER 21.8 -21.1 -21129 1.0 ZBTB40 GPATCH11 HEATR5B GC02M036982
GH02G036961 1.4 Ensembl ENCODE 5.5 -119.2 -119239 7.3 CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 RCOR2 GLIS1 STRN GPATCH11 GC02P036908
GH02G037089 1.1 Ensembl ENCODE 6.5 +6.6 6556 2.7 HDGF PKNOX1 TBL1XR1 BMI1 FEZF1 ZNF366 CBX5 ZNF207 RCOR1 FOS CEBPZ NDUFAF7 CEBPZOS GPATCH11 STRN HEATR5B ENSG00000224891
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPATCH11 on UCSC Golden Path with GeneCards custom track

Promoters for GPATCH11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000115312 -151 1801 PKNOX1 FOXA2 MLX CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for GPATCH11 Gene

Chromosome:
2
Start:
37,084,451 bp from pter
End:
37,099,244 bp from pter
Size:
14,794 bases
Orientation:
Plus strand

Genomic View for GPATCH11 Gene

Genes around GPATCH11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPATCH11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPATCH11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPATCH11 Gene

Proteins for GPATCH11 Gene

  • Protein details for GPATCH11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N954-GPT11_HUMAN
    Recommended name:
    G patch domain-containing protein 11
    Protein Accession:
    Q8N954
    Secondary Accessions:
    • A8K0D9
    • B7Z2G4
    • B8ZZ44

    Protein attributes for GPATCH11 Gene

    Size:
    259 amino acids
    Molecular mass:
    30199 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAH11850.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for GPATCH11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPATCH11 Gene

Post-translational modifications for GPATCH11 Gene

  • Ubiquitination at isoforms=72
  • Modification sites at PhosphoSitePlus

Other Protein References for GPATCH11 Gene

No data available for DME Specific Peptides for GPATCH11 Gene

Domains & Families for GPATCH11 Gene

Gene Families for GPATCH11 Gene

Protein Domains for GPATCH11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPATCH11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N954

UniProtKB/Swiss-Prot:

GPT11_HUMAN :
  • Belongs to the GPATCH11 family.
Family:
  • Belongs to the GPATCH11 family.
genes like me logo Genes that share domains with GPATCH11: view

Function for GPATCH11 Gene

Gene Ontology (GO) - Molecular Function for GPATCH11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GPATCH11: view
genes like me logo Genes that share phenotypes with GPATCH11: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPATCH11 Gene

Localization for GPATCH11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPATCH11 Gene

Chromosome, centromere, kinetochore.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPATCH11 gene
Compartment Confidence
nucleus 4
cytosol 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for GPATCH11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA,IDA 20813266
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with GPATCH11: view

Pathways & Interactions for GPATCH11 Gene

SuperPathways for GPATCH11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPATCH11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GPATCH11 Gene

Drugs & Compounds for GPATCH11 Gene

No Compound Related Data Available

Transcripts for GPATCH11 Gene

Unigene Clusters for GPATCH11 Gene

G patch domain containing 11:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPATCH11 Gene

No ASD Table

Relevant External Links for GPATCH11 Gene

GeneLoc Exon Structure for
GPATCH11
ECgene alternative splicing isoforms for
GPATCH11

Expression for GPATCH11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPATCH11 Gene

Protein differential expression in normal tissues from HIPED for GPATCH11 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (57.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GPATCH11 Gene



Protein tissue co-expression partners for GPATCH11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPATCH11 Gene:

GPATCH11

SOURCE GeneReport for Unigene cluster for GPATCH11 Gene:

Hs.595250

Evidence on tissue expression from TISSUES for GPATCH11 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with GPATCH11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPATCH11 Gene

Orthologs for GPATCH11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPATCH11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC75 35 34
  • 99.18 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPATCH11 34 35
  • 91.25 (n)
dog
(Canis familiaris)
Mammalia GPATCH11 34 35
  • 90.84 (n)
mouse
(Mus musculus)
Mammalia Gpatch11 34 16 35
  • 84.79 (n)
rat
(Rattus norvegicus)
Mammalia Gpatch11 34
  • 83.91 (n)
oppossum
(Monodelphis domestica)
Mammalia GPATCH11 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPATCH11 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC75 35 34
  • 72.78 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPATCH11 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpatch11 34
  • 66.93 (n)
zebrafish
(Danio rerio)
Actinopterygii gpatch11 34 35
  • 57.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10053 34 35
  • 47.41 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_T04H1.5 34
  • 48.83 (n)
T04H1.5 35
  • 29 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G57910 34
  • 49.15 (n)
rice
(Oryza sativa)
Liliopsida Os08g0509500 34
  • 41.7 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToOne
Species where no ortholog for GPATCH11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPATCH11 Gene

ENSEMBL:
Gene Tree for GPATCH11 (if available)
TreeFam:
Gene Tree for GPATCH11 (if available)

Paralogs for GPATCH11 Gene

Pseudogenes.org Pseudogenes for GPATCH11 Gene

genes like me logo Genes that share paralogs with GPATCH11: view

No data available for Paralogs for GPATCH11 Gene

Variants for GPATCH11 Gene

Sequence variations from dbSNP and Humsavar for GPATCH11 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000151344 -- 37,083,994(+) TCCGG(A/C)ATGCA intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000466203 -- 37,095,153(+) AGTAG(A/T)AAAAG intron-variant
rs1001045148 -- 37,082,912(+) AGGAA(C/G)AAAAA intron-variant, upstream-variant-2KB
rs1001559663 -- 37,082,736(+) TTGCT(A/G)TTAAT intron-variant, upstream-variant-2KB
rs1001658554 -- 37,083,736(+) TTACC(C/T)GTTCT intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Variation tolerance for GPATCH11 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPATCH11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPATCH11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPATCH11 Gene

Disorders for GPATCH11 Gene

Relevant External Links for GPATCH11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPATCH11

No disorders were found for GPATCH11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPATCH11 Gene

Publications for GPATCH11 Gene

  1. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S. … Rappsilber J. (Cell 2010) 3 4 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for GPATCH11 Gene

Sources for GPATCH11 Gene

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