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Aliases for GPAT4 Gene

Aliases for GPAT4 Gene

  • Glycerol-3-Phosphate Acyltransferase 4 2 3 5
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 6 (Lysophosphatidic Acid Acyltransferase, Zeta) 2 3
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 6 2 4
  • Lysophosphatidic Acid Acyltransferase Zeta 3 4
  • 1-AGP Acyltransferase 6 3 4
  • EC 2.3.1.15 4 56
  • LPAAT-Zeta 3 4
  • 1-AGPAT 6 3 4
  • AGPAT6 3 4
  • 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Zeta 3
  • Testis Spermatogenesis Apoptosis-Related Protein 7 3
  • Acyl-CoA:Glycerol-3-Phosphate Acyltransferase 4 4
  • Lysophosphatidic Acid Acyltransferase, Zeta 2
  • Glycerol-3-Phosphate Acyltransferase 6 3
  • LPAATZ 3
  • TSARG7 3

External Ids for GPAT4 Gene

Previous HGNC Symbols for GPAT4 Gene

  • AGPAT6

Summaries for GPAT4 Gene

Entrez Gene Summary for GPAT4 Gene

  • Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004]

GeneCards Summary for GPAT4 Gene

GPAT4 (Glycerol-3-Phosphate Acyltransferase 4) is a Protein Coding gene. Among its related pathways are Metabolism and triacylglycerol biosynthesis. An important paralog of this gene is GPAT3.

UniProtKB/Swiss-Prot for GPAT4 Gene

  • Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long-chain fatty acyl-CoAs.

Additional gene information for GPAT4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPAT4 Gene

Genomics for GPAT4 Gene

GeneHancer (GH) Regulatory Elements for GPAT4 Gene

Promoters and enhancers for GPAT4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I041577 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 573.8 +1.3 1279 2.5 HDGF ARID4B SIN3A DMAP1 ZNF766 ZNF143 ZNF207 SP3 ZHX2 REST GPAT4 LOC102723729 IKBKB KAT6A ENSG00000254165 NKX6-3 GOLGA7 PIR42833
GH08I041544 Enhancer 0.8 Ensembl ENCODE 20.2 -32.1 -32077 1.4 CTCF MAX EBF1 ATF2 GABPA POLR2A ATF7 MYC RUNX3 ENSG00000253174 GPAT4 LOC102723729 NKX6-3 GINS4
GH08I041609 Enhancer 0.7 ENCODE 17.7 +32.8 32803 1.9 FOXA2 USF1 MAX RAD21 YY1 TEAD3 POLR2A SCRT2 GATAD2A RXRA PIR42833 NKX6-3 GPAT4 ENSG00000253174 GINS4 LOC102723729 ENSG00000264578
GH08I041612 Enhancer 0.8 ENCODE 12.4 +35.7 35710 1.2 HDGF DRAP1 CTCF RB1 ETV1 ARID4B MAX ZNF2 RAD21 RARA NKX6-3 ENSG00000253174 GINS4 LOC102723729 GPAT4 ENSG00000253389 PIR42833 ENSG00000264578
GH08I041603 Enhancer 1.2 Ensembl ENCODE 7.5 +27.4 27385 1.8 HDGF FOXA2 MLX ARNT ARID4B DMAP1 YY1 E2F8 RXRA SP5 GPAT4 PIR42833 LOC102723729
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPAT4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GPAT4 Gene

Genomic Locations for GPAT4 Gene
chr8:41,577,187-41,625,001
(GRCh38/hg38)
Size:
47,815 bases
Orientation:
Plus strand
chr8:41,434,706-41,482,520
(GRCh37/hg19)

Genomic View for GPAT4 Gene

Genes around GPAT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPAT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPAT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPAT4 Gene

Proteins for GPAT4 Gene

  • Protein details for GPAT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UL3-GPAT4_HUMAN
    Recommended name:
    Glycerol-3-phosphate acyltransferase 4
    Protein Accession:
    Q86UL3
    Secondary Accessions:
    • Q86V89

    Protein attributes for GPAT4 Gene

    Size:
    456 amino acids
    Molecular mass:
    52071 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPAT4 Gene

Selected DME Specific Peptides for GPAT4 Gene

Q86UL3:
  • YSKMIVGN
  • SDIFYFCRKG
  • ILIFPEG
  • LLGISLTVLFTLLLVFIIVPA
  • NHQLYKPYTNGIIAKDPTSLEEEIKEIRRSGSSKALD
  • YAMVGQVHGGLMG
  • WDGGLKR
  • EDAVQFANRVKS
  • CPHVWFERSE
  • FKEEQQK

Post-translational modifications for GPAT4 Gene

No Post-translational modifications

Domains & Families for GPAT4 Gene

Protein Domains for GPAT4 Gene

Suggested Antigen Peptide Sequences for GPAT4 Gene

Graphical View of Domain Structure for InterPro Entry

Q86UL3

UniProtKB/Swiss-Prot:

GPAT4_HUMAN :
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Domain:
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Family:
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
genes like me logo Genes that share domains with GPAT4: view

Function for GPAT4 Gene

Molecular function for GPAT4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-ethylmaleimide (NEM).
UniProtKB/Swiss-Prot Function:
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long-chain fatty acyl-CoAs.

Enzyme Numbers (IUBMB) for GPAT4 Gene

Phenotypes From GWAS Catalog for GPAT4 Gene

Gene Ontology (GO) - Molecular Function for GPAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity TAS --
GO:0004366 glycerol-3-phosphate O-acyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0102420 sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity IEA --
genes like me logo Genes that share ontologies with GPAT4: view
genes like me logo Genes that share phenotypes with GPAT4: view

Animal Model Products

miRNA for GPAT4 Gene

miRTarBase miRNAs that target GPAT4

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPAT4 Gene

Localization for GPAT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPAT4 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPAT4 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 2
mitochondrion 2
peroxisome 2
cytosol 1

Gene Ontology (GO) - Cellular Components for GPAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS,IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA,IEA 18238778
GO:0016021 integral component of membrane NAS,IEA 18238778
genes like me logo Genes that share ontologies with GPAT4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPAT4 Gene

Pathways & Interactions for GPAT4 Gene

genes like me logo Genes that share pathways with GPAT4: view

UniProtKB/Swiss-Prot Q86UL3-GPAT4_HUMAN

  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.

Gene Ontology (GO) - Biological Process for GPAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002071 glandular epithelial cell maturation IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006637 acyl-CoA metabolic process IDA 18238778
GO:0006641 triglyceride metabolic process IEA --
genes like me logo Genes that share ontologies with GPAT4: view

No data available for SIGNOR curated interactions for GPAT4 Gene

Drugs & Compounds for GPAT4 Gene

(3) Drugs for GPAT4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hexanoyl-CoA Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0
Coenzyme A Investigational Nutra 0

(50) Additional Compounds for GPAT4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with GPAT4: view

Transcripts for GPAT4 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPAT4 Gene

No ASD Table

Relevant External Links for GPAT4 Gene

GeneLoc Exon Structure for
GPAT4
ECgene alternative splicing isoforms for
GPAT4

Expression for GPAT4 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPAT4 Gene:

GPAT4

mRNA Expression by UniProt/SwissProt for GPAT4 Gene:

Q86UL3-GPAT4_HUMAN
Tissue specificity: Ubiquitous. Relatively high level of expression in skeletal muscle, heart and testis. Relatively low level of expression in lung.

Evidence on tissue expression from TISSUES for GPAT4 Gene

  • Skin(3.4)
  • Nervous system(2.7)
  • Liver(2.4)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPAT4 Gene

Orthologs for GPAT4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPAT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGPAT6 33 34
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia AGPAT6 33 34
  • 92.76 (n)
oppossum
(Monodelphis domestica)
Mammalia AGPAT6 34
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agpat6 33
  • 89.18 (n)
mouse
(Mus musculus)
Mammalia Agpat6 33 34
  • 88.6 (n)
Gpat4 16
cow
(Bos Taurus)
Mammalia AGPAT6 33 34
  • 88.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia AGPAT6 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves AGPAT6 33 34
  • 82.78 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 94 (a)
OneToMany
-- 34
  • 91 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia agpat6 33
  • 75.79 (n)
zebrafish
(Danio rerio)
Actinopterygii agpat6 33 34
  • 73.9 (n)
wufi89e03 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002084 33
  • 59.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3209 33 34
  • 57.81 (n)
CG15450 34
  • 36 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea acl-4 33 34
  • 57.61 (n)
acl-5 34
  • 39 (a)
ManyToMany
M79.2 34
  • 25 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons GPAT9 33
  • 49.81 (n)
rice
(Oryza sativa)
Liliopsida Os07g0531600 33
  • 49.13 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1550 34
  • 46 (a)
OneToMany
Species where no ortholog for GPAT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPAT4 Gene

ENSEMBL:
Gene Tree for GPAT4 (if available)
TreeFam:
Gene Tree for GPAT4 (if available)

Paralogs for GPAT4 Gene

Paralogs for GPAT4 Gene

Pseudogenes.org Pseudogenes for GPAT4 Gene

genes like me logo Genes that share paralogs with GPAT4: view

Variants for GPAT4 Gene

Sequence variations from dbSNP and Humsavar for GPAT4 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000085147 -- 41,590,622(+) C/T intron_variant
rs1000099675 -- 41,576,490(+) C/T upstream_transcript_variant
rs1000183045 -- 41,591,238(+) AA/AAA intron_variant
rs1000196096 -- 41,625,079(+) A/C downstream_transcript_variant
rs1000231997 -- 41,618,212(+) G/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPAT4 Gene

Variant ID Type Subtype PubMed ID
esv3576565 CNV gain 25503493
nsv1077039 CNV deletion 25765185
nsv831299 CNV loss 17160897

Variation tolerance for GPAT4 Gene

Residual Variation Intolerance Score: 16.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPAT4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPAT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPAT4 Gene

Disorders for GPAT4 Gene

No disorders were found for GPAT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPAT4 Gene

Publications for GPAT4 Gene

  1. AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. (PMID: 18238778) Chen YQ … Cao G (The Journal of biological chemistry 2008) 2 3 4 22 58
  2. Cloning and identification of the human LPAAT-zeta gene, a novel member of the lysophosphatidic acid acyltransferase family. (PMID: 12938015) Li D … Zhao S (Journal of human genetics 2003) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for GPAT4 Gene

Sources for GPAT4 Gene

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