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Aliases for GPAT4 Gene

Aliases for GPAT4 Gene

  • Glycerol-3-Phosphate Acyltransferase 4 2 3 5
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 6 (Lysophosphatidic Acid Acyltransferase, Zeta) 2 3
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 6 2 4
  • Lysophosphatidic Acid Acyltransferase Zeta 3 4
  • 1-AGP Acyltransferase 6 3 4
  • EC 2.3.1.15 4 63
  • LPAAT-Zeta 3 4
  • 1-AGPAT 6 3 4
  • AGPAT6 3 4
  • 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Zeta 3
  • Testis Spermatogenesis Apoptosis-Related Protein 7 3
  • Acyl-CoA:Glycerol-3-Phosphate Acyltransferase 4 4
  • Glycerol-3-Phosphate Acyltransferase 6 3
  • Glycerol-3-Phosphate Acyltransferase-4 3
  • Lysophosphatidic Acid Acyltransferase 2
  • LPAATZ 3
  • TSARG7 3
  • Zeta 2

External Ids for GPAT4 Gene

Previous HGNC Symbols for GPAT4 Gene

  • AGPAT6

Summaries for GPAT4 Gene

Entrez Gene Summary for GPAT4 Gene

  • Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004]

GeneCards Summary for GPAT4 Gene

GPAT4 (Glycerol-3-Phosphate Acyltransferase 4) is a Protein Coding gene. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). An important paralog of this gene is GPAT3.

UniProtKB/Swiss-Prot for GPAT4 Gene

  • Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long-chain fatty acyl-CoAs.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPAT4 Gene

Genomics for GPAT4 Gene

Regulatory Elements for GPAT4 Gene

Promoters for GPAT4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPAT4 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPAT4 Gene

Chromosome:
8
Start:
41,577,187 bp from pter
End:
41,625,001 bp from pter
Size:
47,815 bases
Orientation:
Plus strand

Genomic View for GPAT4 Gene

Genes around GPAT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPAT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPAT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPAT4 Gene

Proteins for GPAT4 Gene

  • Protein details for GPAT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UL3-GPAT4_HUMAN
    Recommended name:
    Glycerol-3-phosphate acyltransferase 4
    Protein Accession:
    Q86UL3
    Secondary Accessions:
    • Q86V89

    Protein attributes for GPAT4 Gene

    Size:
    456 amino acids
    Molecular mass:
    52071 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPAT4 Gene

Proteomics data for GPAT4 Gene at MOPED

Post-translational modifications for GPAT4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPAT4 Gene

Domains & Families for GPAT4 Gene

Protein Domains for GPAT4 Gene

Suggested Antigen Peptide Sequences for GPAT4 Gene

Graphical View of Domain Structure for InterPro Entry

Q86UL3

UniProtKB/Swiss-Prot:

GPAT4_HUMAN :
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Domain:
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Family:
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
genes like me logo Genes that share domains with GPAT4: view

Function for GPAT4 Gene

Molecular function for GPAT4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-ethylmaleimide (NEM).
UniProtKB/Swiss-Prot Function:
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long-chain fatty acyl-CoAs.

Enzyme Numbers (IUBMB) for GPAT4 Gene

genes like me logo Genes that share phenotypes with GPAT4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPAT4

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPAT4 Gene

Localization for GPAT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPAT4 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for GPAT4 Gene

Pathways & Interactions for GPAT4 Gene

genes like me logo Genes that share pathways with GPAT4: view

UniProtKB/Swiss-Prot Q86UL3-GPAT4_HUMAN

  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.

Gene Ontology (GO) - Biological Process for GPAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002071 glandular epithelial cell maturation IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006641 triglyceride metabolic process IEA --
GO:0006656 phosphatidylcholine biosynthetic process IDA 18238778
GO:0007595 lactation IEA,ISS --
genes like me logo Genes that share ontologies with GPAT4: view

No data available for SIGNOR curated interactions for GPAT4 Gene

Drugs & Compounds for GPAT4 Gene

(2) Drugs for GPAT4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0
Coenzyme A Nutra 0

(51) Additional Compounds for GPAT4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with GPAT4: view

Transcripts for GPAT4 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for GPAT4 Gene

No ASD Table

Relevant External Links for GPAT4 Gene

GeneLoc Exon Structure for
GPAT4
ECgene alternative splicing isoforms for
GPAT4

Expression for GPAT4 Gene

mRNA Expression by UniProt/SwissProt for GPAT4 Gene

Q86UL3-GPAT4_HUMAN
Tissue specificity: Ubiquitous. Relatively high level of expression in skeletal muscle, heart and testis. Relatively low level of expression in lung.

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPAT4 Gene

Orthologs for GPAT4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPAT4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AGPAT6 35
  • 88.45 (n)
  • 97.37 (a)
AGPAT6 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGPAT6 35
  • 92.76 (n)
  • 98.9 (a)
AGPAT6 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agpat6 35
  • 88.6 (n)
  • 97.59 (a)
Gpat4 16
Agpat6 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AGPAT6 35
  • 99.63 (n)
  • 99.78 (a)
AGPAT6 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agpat6 35
  • 89.18 (n)
  • 97.15 (a)
oppossum
(Monodelphis domestica)
Mammalia AGPAT6 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AGPAT6 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves AGPAT6 35
  • 82.78 (n)
  • 95.82 (a)
AGPAT6 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 91 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia agpat6 35
  • 75.79 (n)
  • 85.65 (a)
zebrafish
(Danio rerio)
Actinopterygii agpat6 35
  • 73.9 (n)
  • 81.21 (a)
wufi89e03 35
agpat6 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002084 35
  • 59.28 (n)
  • 55.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3209 35
  • 57.81 (n)
  • 54.64 (a)
CG15450 36
  • 36 (a)
ManyToMany
CG3209 36
  • 43 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea acl-4 35
  • 57.61 (n)
  • 56.42 (a)
acl-4 36
  • 35 (a)
ManyToMany
acl-5 36
  • 39 (a)
ManyToMany
M79.2 36
  • 25 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons GPAT9 35
  • 49.81 (n)
  • 39.94 (a)
rice
(Oryza sativa)
Liliopsida Os07g0531600 35
  • 49.13 (n)
  • 41.23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1550 36
  • 46 (a)
OneToMany
Species with no ortholog for GPAT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPAT4 Gene

ENSEMBL:
Gene Tree for GPAT4 (if available)
TreeFam:
Gene Tree for GPAT4 (if available)

Paralogs for GPAT4 Gene

Paralogs for GPAT4 Gene

Pseudogenes.org Pseudogenes for GPAT4 Gene

genes like me logo Genes that share paralogs with GPAT4: view

Variants for GPAT4 Gene

Sequence variations from dbSNP and Humsavar for GPAT4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs9559 -- 41,624,749(+) TTGAT(C/T)ATTTC utr-variant-3-prime
rs749540 -- 41,623,577(+) TCTCT(A/G)TTTTT utr-variant-3-prime
rs749541 -- 41,623,705(+) CTTGA(A/G)GGTGA utr-variant-3-prime
rs755552 -- 41,605,119(+) AAATA(C/T)TGGGA intron-variant
rs890220 -- 41,620,842(+) TGAGC(A/G)TGGCT intron-variant

Variation tolerance for GPAT4 Gene

Residual Variation Intolerance Score: 16.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPAT4 Gene

HapMap Linkage Disequilibrium report
GPAT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPAT4 Gene

Disorders for GPAT4 Gene

Relevant External Links for GPAT4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPAT4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPAT4

No disorders were found for GPAT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPAT4 Gene

Publications for GPAT4 Gene

  1. AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. (PMID: 18238778) Chen Y.Q. … Cao G. (J. Biol. Chem. 2008) 2 3 4 23 67
  2. Cloning and identification of the human LPAAT-zeta gene, a novel member of the lysophosphatidic acid acyltransferase family. (PMID: 12938015) Li D. … Zhao S. (J. Hum. Genet. 2003) 2 3
  3. Glycerol-3-phosphate Acyltransferase Isoform-4 (GPAT4) Limits Oxidation of Exogenous Fatty Acids in Brown Adipocytes. (PMID: 25918168) Cooper D.E. … Coleman R.A. (J. Biol. Chem. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for GPAT4 Gene

Sources for GPAT4 Gene

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