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GPANK1 Gene

protein-coding   GIFtS: 46
GCID: GC06M031695

G Patch Domain And Ankyrin Repeats 1

(Previous name: HLA-B associated transcript 4)
(Previous symbol: BAT4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G Patch Domain And Ankyrin Repeats 11 2     GPATCH102 3
BAT41 2 3 5     HLA-B-Associated Transcript 42 3
G Patch Domain Containing 101 2     D6S54E2 5
Ankyrin Repeat Domain-Containing Protein 592 3     Ankyrin Repeat Domain 591
G Patch Domain-Containing Protein 102 3     HLA-B Associated Transcript 41
Protein G52 3     G Patch Domain And Ankyrin Repeat-Containing Protein 12
ANKRD592 3     G Patch Domain And Ankyrin Repeats-Containing Protein 12
G52 3     Protein BAT42

External Ids:    HGNC: 139201   Entrez Gene: 79182   Ensembl: ENSG000002044387   OMIM: 1426105   UniProtKB: O958723   

Export aliases for GPANK1 gene to outside databases

Previous GC identifers: GC06M031417 GC06M031631 GC06M031635 GC06M031638 GC06M031642 GC06M031647 GC06M031651


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GPANK1 Gene:
This gene is located in a cluster of HLA-B-associated transcripts, which is included in the human major
histocompatability complex III region. This gene encodes a protein which is thought to play a role in immunity.
Multiple alternatively spliced variants, encoding the same protein, have been identified. (provided by RefSeq,
Nov 2010)

GeneCards Summary for GPANK1 Gene:
GPANK1 (G patch domain and ankyrin repeats 1) is a protein-coding gene. GO annotations related to this gene include nucleic acid binding.

Gene Wiki entry for GPANK1 (BAT4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NT_113891.3  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  NT_167249.2  
NC_018917.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for GPANK1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPANK1 promoter sequence
   Search Chromatin IP Primers for GPANK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPANK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

GPANK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPANK1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031695:  view genomic region     (about GC identifiers)

Start:
31,629,006 bp from pter      End:
31,634,060 bp from pter
Size:
5,055 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_113891.2 3,138,625-3,143,680      Chr6-,NT_167247 3,008,686-3,013,740      Chr6-,NT_167245 2,914,585-2,919,640     
Chr6-,NT_167248 2,922,643-2,927,703      Chr6-,NT_167246 2,971,896-2,976,950      Chr6-,NT_167249 2,959,804-2,964,865     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GPAN1_HUMAN, O95872 (See protein sequence)
Recommended Name: G patch domain and ankyrin repeat-containing protein 1  
Size: 356 amino acids; 39314 Da
Secondary accessions: A6NG25 B0UXA2 Q5SQ49

Explore the universe of human proteins at neXtProt for GPANK1: NX_O95872

Explore proteomics data for GPANK1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys103, Lys261

  • See GPANK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001186166.1  NP_001186167.1  NP_001186168.1  NP_001186169.1  NP_149417.1  

    ENSEMBL proteins: 
     ENSP00000365071   ENSP00000365060   ENSP00000365057   ENSP00000365059   ENSP00000365065  
     ENSP00000395307   ENSP00000409349   ENSP00000395484  

    GPANK1 Human Recombinant Protein Products:

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    Novus Biologicals GPANK1 Proteins
    Novus Biologicals GPANK1 Lysates
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GPANK1 

     
    antibodies-online proteins for GPANK1 (4 products) 

     
    antibodies-online peptides for GPANK1

    GPANK1 Antibody Products:

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    antibodies-online antibodies for GPANK1 (11 products) 

    GPANK1 Assay Products:

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    antibodies-online kits for GPANK1 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPATCH: G patch domain containing
    ANKRD: Ankyrin repeat domain containing

    3 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR000467 G_patch_dom
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry O95872

    ProtoNet protein and cluster: O95872

    2 Blocks protein domains:
    IPB000467 D111/G-patch domain
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: GPAN1_HUMAN, O95872
    Similarity: Contains 2 ANK repeats
    Similarity: Contains 1 G-patch domain


    Find genes that share domains with GPANK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with GPANK1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GPANK1:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for GPANK1

    miRNA
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    miRTarBase miRNAs that target GPANK1:
    hsa-mir-215-5p (MIRT024275)

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    2 qRT-PCR Assays for microRNAs that regulate GPANK1:
    hsa-miR-2115 hsa-miR-4276
    SwitchGear 3'UTR luciferase reporter plasmidGPANK1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GPANK1

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPANK1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GPANK1
    Interactions:

        Search GeneGlobe Interaction Network for GPANK1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5 Interacting proteins for GPANK1 (O958722, 3 ENSP000003650574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-68152 I2D: score=5 STRING: ENSP00000311695
    NPM1P067483, ENSP000002969304I2D: score=1 STRING: ENSP00000296930
    GRB2P629933I2D: score=2 
    LZTS2Q9BRK43I2D: score=1 
    SAA4P355423I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPANK1 (GPAN1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GPANK1 gene (5 alternative transcripts): 
    NM_001199237.1  NM_001199238.1  NM_001199239.1  NM_001199240.1  NM_033177.3  

    Unigene Cluster for GPANK1:

    G patch domain and ankyrin repeats 1
    Hs.247478  [show with all ESTs]
    Unigene Representative Sequence: AK123707
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375906(uc003nvn.3 uc021yuu.1 uc003nvo.4 uc003nvp.4 uc003nvq.3)
    ENST00000375896 ENST00000375893 ENST00000375895 ENST00000375900 ENST00000458083
    ENST00000445768 ENST00000456540
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate GPANK1:
    hsa-miR-2115 hsa-miR-4276
    SwitchGear 3'UTR luciferase reporter plasmidGPANK1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GPANK1
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    GenScript: all cDNA clones in your preferred vector (see all 5): GPANK1 (NM_001199237)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat GPANK1
      QuantiFast Probe-based Assays in human, mouse, rat GPANK1

    Additional mRNA sequence: 

    AJ420471.1 AK123707.1 AK314056.1 BC008783.1 BC018875.2 

    8 DOTS entries:

    DT.313298  DT.40250887  DT.100732064  DT.100797071  DT.100797072  DT.97859091  DT.91821546  DT.95175629 

    Selected AceView cDNA sequences (see all 49):

    BV188195 BM677266 CD369616 AA460293 CA421457 AI089792 BM721664 AA461581 
    AA224029 CD514026 BX352972 AA897700 AI991338 BF975913 AA677567 AA777142 
    BI912356 BX375482 AW083218 BG123018 BE616971 AI032575 AL530297 AW444916 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPANK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCGGCCCT
    GPANK1 Expression
    About this image

    GPANK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPANK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.247478
        Custom PCR Arrays for GPANK1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPANK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GPANK1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpank11 , 5 G patch domain and ankyrin repeats 11, 5 80.6(n)1
    80.98(a)1
      17 (18.59 cM)5
    818451  NM_001128597.11  NP_001122069.11 
     351214555 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gpank11 G patch domain and ankyrin repeats 1 48.51(n)
    42.26(a)
      779861  NM_001078939.1  NP_001072407.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1717771 zgc:171777 49.59(n)
    41.46(a)
      100126023  NM_001105703.1  NP_001099173.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG81521 CG8152 44.93(n)
    34.8(a)
      36696  NM_137184.2  NP_611028.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK1320.76
    Protein ZK1320.7 (ZK1320.7) mRNA, complete cds
    23(a)
    1 ↔ 1
    II(9671608-9673261) WBGene00014256


    ENSEMBL Gene Tree for GPANK1 (if available)
    TreeFam Gene Tree for GPANK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPANK1 (see all 58)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs779974191,2
    C--31630603(+) AGGAAC/TAAATT 5 -- int10--------
    rs593459591,2
    C--31630665(+) GAGGCG/AGGCAG 5 -- int13Minor allele frequency- A:0.17CSA NA EA 242
    rs92815491,2
    C--31630725(+) ttttt-/T/TT  
            
    gagat
    5 -- int10--------
    rs8052601,2
    C,A--31630831(-) gctgaC/G/Tgcagg 5 -- int13WA CSA NA 123
    rs1508181421,2
    C--31630928(+) CGGAGA/GTTGCA 5 -- int10--------
    rs31175801,2
    C,F--31630968(-) GTCGCC/TCAGGC 5 -- int16Minor allele frequency- T:0.15WA CSA NA EA 364
    rs1904645001,2
    --31631066(+) TCCAGA/GCTGGT 5 -- int10--------
    rs1381258981,2
    --31631078(+) CAAAGG/TTGGTG 5 -- int10--------
    rs760724741,2
    C--31631334(+) GCACTA/GTTCTA 5 -- int11Minor allele frequency- G:0.01NA 120
    rs8052591,2
    C,F,H--31631377(-) agaatT/CGTTGT 5 -- int119Minor allele frequency- C:0.12NS EA NA WA 2362

    HapMap Linkage Disequilibrium report for GPANK1 (31629006 - 31634060 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GPANK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830627CNV Loss17160897
    dgv6581n71CNV Loss21882294
    nsv462871CNV Loss19166990
    nsv884418CNV Gain21882294

    Human Gene Mutation Database (HGMD): GPANK1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPANK1
    DNA2.0 Custom Variant and Variant Library Synthesis for GPANK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142610    OMIM disorders: --


    Find genes that share disorders with GPANK1           About GenesLikeMe


    Export disorders for GPANK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPANK1 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with GPANK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    3. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (Genome Res. 2003)
    4. A new cluster of genes within the human major histocompatibility complex. (PubMed id 2911734)1, 3 Spies T....Strominger J.L. (Science 1989)
    5. Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B. (PubMed id 2813433)1, 3 Spies T....Strominger J.L. (Proc. Natl. Acad. Sci. U.S.A. 1989)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    8. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O.... Lill R. (Science 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (Nature 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7918 HGNC: 13920 AceView: BAT4.1 Ensembl:ENSG00000204438 euGenes: HUgn7918
    ECgene: GPANK1 H-InvDB: GPANK1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPANK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GPANK1 gene:
    Search GeneIP for patents involving GPANK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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