GPANK1 Gene
protein-coding GIFtS: 47
GCID: GC06M031647
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G patch domain and ankyrin repeats 1(Previous name: HLA-B associated transcript 4 )
(Previous symbol: BAT4)
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Aliases
for GPANK1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| G Patch Domain And Ankyrin Repeats 11 2 | | Protein G52 3 | | BAT41 2 3 5 | | HLA-B-Associated Transcript 42 3 | | ANKRD591 2 3 | | HLA-B Associated Transcript 41 | | G51 2 3 | | G Patch Domain And Ankyrin Repeat-Containing Protein 12 | | GPATCH101 2 3 | | G Patch Domain And Ankyrin Repeats-Containing Protein 12 | | D6S54E1 2 5 | | G Patch Domain Containing 102 | | Ankyrin Repeat Domain-Containing Protein 592 3 | | Protein BAT42 | | G Patch Domain-Containing Protein 102 3 | | |
Export aliases for GPANK1 gene to outside databasesPrevious GC identifers: GC06M031417 GC06M031631 GC06M031635 GC06M031638 GC06M031642 |
Summaries
for GPANK1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GPANK1:
This gene is located in a cluster of HLA-B-associated transcripts, which is included in the human majorhistocompatability complex III region. This gene encodes a protein which is thought to play a role in immunity.Multiple alternatively spliced variants, encoding the same protein, have been identified. (provided by RefSeq, Nov2010)
Gene Wiki entry for GPANK1 (BAT4)
|
Genomic Views
for GPANK1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167245.1 NT_167246.1 NT_167247.1 NT_167248.1
- NT_167249.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for GPANK1
Other transcription factors
Search SABiosciences Chromatin IP Primers for GPANK1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPANK1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.3GPANK1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M031647: view genomic region
(about GC identifiers)
Start:
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31,629,006 bp from pter |
End:
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31,634,060 bp from pter |
Size:
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5,055 bases |
Orientation:
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minus strand |
6 alternative locations:
| Chr6-,ALT_REF_LOCI_4 31,592,411-31,595,712 | Chr6-,ALT_REF_LOCI_3 31,611,188-31,626,383 | Chr6-,ALT_REF_LOCI_6 31,619,246-31,658,990 | | Chr6-,ALT_REF_LOCI_2 31,616,421-31,659,767 | Chr6-,ALT_REF_LOCI_5 31,620,965-31,624,266 | Chr6-,ALT_REF_LOCI_7 31,550,130-31,553,433 | |
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Proteins
for GPANK1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GPAN1_HUMAN, O95872 (See
protein sequence)Recommended Name: G patch domain and ankyrin repeat-containing protein 1 Size: 356 amino acids; 39314 Da
Secondary accessions: A6NG25 B0UXA2 Q5SQ49Explore the universe of human proteins at neXtProt for GPANK1: NX_O95872
GPANK1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001186166.1 NP_001186167.1 NP_001186168.1 NP_001186169.1 NP_149417.1
ENSEMBL proteins: ENSP00000365071 ENSP00000365060 ENSP00000365057 ENSP00000365059 ENSP00000365065 ENSP00000404158 ENSP00000395307 ENSP00000409349 ENSP00000400752 ENSP00000395484
Human Recombinant Protein Products:
GPANK1 Antibody Products:
Assay Products for GPANK1: |
Protein
Domains /
Families
for GPANK1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GPANK1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95872ProtoNet protein and cluster: O95872 2 Blocks protein families: IPB000467 D111/G-patch domain IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: GPAN1_HUMAN, O95872Similarity: Contains 2 ANK repeatsSimilarity: Contains 1 G-patch domain |
Function
for GPANK1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPANK1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPANK1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 5): GPANK1 (NM_001199237) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GPANK1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPANK1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPANK1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- | | GO:0005515 | protein binding |
-- | -- |
GPANK1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for GPANK1:
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Pathways & Interactions
for GPANK1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPANK1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5 Interacting proteins for GPANK1 (O958722, 3 ENSP000003650574) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for GPANK1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GPANK1
Search CenterWatch for drugs/clinical trials and news about GPANK1 / GPAN1
|
Transcripts
for GPANK1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GPANK1 gene (5 alternative transcripts): NM_001199237.1 NM_001199238.1 NM_001199239.1 NM_001199240.1 NM_033177.3 Unigene Clusters for GPANK1: G patch domain and ankyrin repeats 1 Hs.247478 [show with all ESTs], Hs.732291 [show with all ESTs]Unigene Representative Sequences: AK123707, BM54296910 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000375906(uc003nvn.3 uc021yuu.1 uc003nvo.4 uc003nvp.4 uc003nvq.3)
ENST00000375896 ENST00000375893 ENST00000375895 ENST00000375900 ENST00000440842
ENST00000458083 ENST00000445768 ENST00000432291 ENST00000456540
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPANK1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPANK1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): GPANK1 (NM_001199237) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GPANK1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPANK1 |
Additional cDNA sequence: AF087962.1 16 DOTS entries: DT.313298 DT.40250887 DT.97859091 DT.100797071 DT.100732064 DT.100797079 DT.100797082 DT.95175640 DT.100797072 DT.121325884 DT.95175639 DT.95175638 DT.121325869 DT.95175629 DT.95175632 DT.91821546 24/49 AceView cDNA sequences (see all 49): BM721664 AA224029 CA421457 AA461581 CD369616 BM677266 AI089792 AA460293 CD514026 BV188195 AW083218 AI219085 AL530297 AI458871 AW444916 AA587058 AL530296 BX352972 BE616971 AI991338 CB120434 AA011365 AA897700 BG123018
GeneLoc Exon Structure
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Expression
for GPANK1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GPANK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCCGGCCCT
About this image
See GPANK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GPANK1
SOURCE GeneReport for Unigene clusters: Hs.247478 Hs.732291
SABiosciences Custom PCR Arrays for GPANK1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPANK1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GPANK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPANK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPANK1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPANK1 |
Orthologs
for GPANK1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for GPANK1 gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for GPANK1 (if available)
TreeFam Gene Tree for GPANK1 (if available) |
Paralogs
for GPANK1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for GPANK1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GPANK1 (31629006 - 31634060 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GPANK1: --
Human Gene Mutation Database (HGMD): GPANK1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPANK1 |
|
Disorders
/ Diseases
for GPANK1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GPANK1 for disorders About GeneDecksing
OMIM gene information: 142610
OMIM disorders: --
6  diseases for GPANK1: About MalaCardssystemic lupus erythematosus lupus erythematosus rheumatoid arthritis arthritis
esophagitis adenocarcinoma
Export disorders for GPANK1 gene to outside databases
|
Publications
for GPANK1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GPANK1 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with GPANK1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (2003)
- A new cluster of genes within the human major histocompatibility complex. (PubMed id 2911734)1, 3 Spies T....Strominger J.L. (1989)
- Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B. (PubMed id 2813433)1, 3 Spies T....Strominger J.L. (1989)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1 Liu C.Y....Christiani D.C. (2010)
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External Searches for GPANK1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing GPANK1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GPANK1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GPANK1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GPANK1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for GPANK1 gene:
Search GeneIP for patents involving GPANK1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GPANK1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GPANK1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GPANK1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPANK1 | | | OriGene Protein Over-expression Lysate for GPANK1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GPANK1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPANK1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPANK1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for GPANK1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | GPANK1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPANK1 |
|  |  |  | | | | Search ThermoFisher Antibodies for GPANK1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPANK1 |
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