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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPAM Gene

protein-coding   GIFtS: 63
GCID: GC10M113899

Glycerol-3-Phosphate Acyltransferase, Mitochondrial

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glycerol-3-Phosphate Acyltransferase, Mitochondrial1 2     GPAT2
GPAT-12 3     Glycerol 3-Phosphate Acyltransferase, Mitochondrial2
GPAT12 3     Glycerol-3-Phosphate Acyltransferase 1, Mitochondrial2
EC 2.3.1.153 8     KIAA15603
Glycerol-3-Phosphate Acyltransferase 11     EC 2.3.18
mitochondrial1     

External Ids:    HGNC: 248651   Entrez Gene: 576782   Ensembl: ENSG000001199277   OMIM: 6023955   UniProtKB: Q9HCL23   

Export aliases for GPAM gene to outside databases

Previous GC identifers: GC10U990097 GC10M113575 GC10M107537


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GPAM Gene:
This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of
glycerolipids. This metabolic pathway's first step is catalyzed by the encoded enzyme. Two forms for this enzyme
exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript
variants have been described for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for GPAM Gene: 
GPAM (glycerol-3-phosphate acyltransferase, mitochondrial) is a protein-coding gene. Diseases associated with GPAM include esophageal adenocarcinoma, and insulin resistance, and among its related super-pathways are CDP-diacylglycerol biosynthesis I and Activation of Gene Expression by SREBP (SREBF). GO annotations related to this gene include glycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is GNPAT.

UniProtKB/Swiss-Prot: GPAT1_HUMAN, Q9HCL2
Function: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in
glycerolipid biosynthesis

Gene Wiki entry for GPAM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPAM gene promoter:
         Max1   FOXO3   Pax-2   Pax-2a   HNF-3beta   LCR-F1   GATA-2   Pax-2b   ZIC2/Zic2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GPAM promoter sequence
   Search SABiosciences Chromatin IP Primers for GPAM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPAM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.2   Ensembl cytogenetic band:  10q25.2   HGNC cytogenetic band: 10q25.3

GPAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPAM gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M113899:  view genomic region     (about GC identifiers)

Start:
113,909,622 bp from pter      End:
113,975,135 bp from pter
Size:
65,514 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GPAT1_HUMAN, Q9HCL2 (See protein sequence)
Recommended Name: Glycerol-3-phosphate acyltransferase 1, mitochondrial precursor  
Size: 828 amino acids; 93795 Da
Subcellular location: Mitochondrion outer membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: Q5VW51 Q86TA3

Explore the universe of human proteins at neXtProt for GPAM: NX_Q9HCL2

Explore proteomics data for GPAM at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HCL2

  • 4/9 DME Specific Peptides for GPAM (Q9HCL2) (see all 9)
     HRSHIDY  RPFVGRCC  FLEGTRSR  GTIDVSYLP 

    GPAM Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GPAM Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001231878.1  NP_065969.3  

    ENSEMBL proteins: 
     ENSP00000265276   ENSP00000358433   ENSP00000409242  
    Reactome Protein details: Q9HCL2
    Human Recombinant Protein Products for GPAM: 
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    Novus Biologicals GPAM Proteins
    Novus Biologicals GPAM Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GPAM 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005741mitochondrial outer membrane TAS--
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    GPAM for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR022284 G3P_O-AcylTrfase
     IPR002123 Plipid/glycerol_acylTrfase

    Graphical View of Domain Structure for InterPro Entry Q9HCL2

    ProtoNet protein and cluster: Q9HCL2

    1 Blocks protein domain: IPB002123 Phospholipid/glycerol acyltransferase

    UniProtKB/Swiss-Prot: GPAT1_HUMAN, Q9HCL2
    Domain: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the
    phosphate moiety of the glycerol-3-phosphate (By similarity)
    Similarity: Belongs to the GPAT/DAPAT family


    GPAM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPAT1_HUMAN, Q9HCL2
    Function: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in
    glycerolipid biosynthesis
    Catalytic activity: Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate

         Enzyme Numbers (IUBMB): EC 2.3.1.151 2 EC 2.3.12

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004366glycerol-3-phosphate O-acyltransferase activity IMP18238778
    GO:0016746transferase activity, transferring acyl groups ----
         
    GPAM for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Gpam):
     adipose tissue  growth/size  homeostasis/metabolism  liver/biliary system  no phenotypic analysis 

    GPAM for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GPAM: Gpamtm1Rcol Gpamtm1Lex

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GPAM 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GPAM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GPAM 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GPAM 

    miRNA
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    miRTarBase miRNAs that target GPAM:
    hsa-mir-16 (MIRT001462)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GPAM
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate GPAM (see all 39):
    hsa-miR-607 hsa-miR-29a hsa-miR-128 hsa-miR-218 hsa-miR-105 hsa-miR-570 hsa-miR-183* hsa-miR-9
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPAM


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GPAM About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1CDP-diacylglycerol biosynthesis I
    CDP-diacylglycerol biosynthesis I0.94
    triacylglycerol biosynthesis0.50
    phosphatidylglycerol biosynthesis II (non-plastidic)0.94
    Triacylglyceride Synthesis0.36
    2Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)0.67
    SREBP signalling0.37
    Activation of Gene Expression by SREBP (SREBF)0.67
    3Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Glycerophospholipid metabolism0.62
    Phospholipid metabolism0.64
    4Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    5Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Fatty acid, triacylglycerol, and ketone body metabolism0.52

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/6 BioSystems Pathways for GPAM (see all 6)
        SREBP signalling
    CDP-diacylglycerol biosynthesis I
    Validated targets of C-MYC transcriptional activation
    Triacylglyceride Synthesis
    triacylglycerol biosynthesis


    5/9        Reactome Pathways for GPAM (see all 9)
        Synthesis of PA
    Metabolism
    Phospholipid metabolism
    Triglyceride Biosynthesis
    Fatty acid, triacylglycerol, and ketone body metabolism

    1 PharmGKB Pathway for GPAM
        Metformin Pathway, Pharmacodynamic

    3         Kegg Pathways  (Kegg details for GPAM):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: GPAT1_HUMAN, Q9HCL2
    Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol
    3-phosphate: step 1/3


    GPAM for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPAM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/31 Interacting proteins for GPAM (ENSP000002652764) via UniProtKB, MINT, STRING, and/or I2D (see all 31)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGPAT2ENSP000003607614STRING: ENSP00000360761
    AGPAT3ENSP000002915724STRING: ENSP00000291572
    AGPAT4ENSP000003140364STRING: ENSP00000314036
    AGPAT5ENSP000002855184STRING: ENSP00000285518
    AGPAT6ENSP000003801844STRING: ENSP00000380184
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006631fatty acid metabolic process IEA--
    GO:0006637acyl-CoA metabolic process IEA--
    GO:0006641triglyceride metabolic process ----
    GO:0006644phospholipid metabolic process TAS--
    GO:0006650glycerophospholipid metabolic process ----

    GPAM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GPAM for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPAM (GPAT1)

    10/33 HMDB Compounds for GPAM (see all 33)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--

    10/13 Novoseek inferred chemical compound relationships for GPAM gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycerol 3-phosphate 94.6 87 14668349 (3), 18238778 (3), 2176832 (2), 11399150 (2) (see all 44)
    triacylglycerol 79.7 19 16864897 (2), 17170135 (2), 19336658 (1), 9706228 (1) (see all 12)
    phosphatidate 73.6 1 19336658 (1)
    acyl-coa 71.5 4 8463874 (1), 9452481 (1), 15175356 (1)
    dhap 65.8 3 16423830 (1), 19720088 (1)
    fatty acid 62 14 9706228 (2), 17066326 (1), 14519791 (1), 17005995 (1) (see all 9)
    sterol 61 5 9054427 (2), 17577393 (1)
    acetyl-coa 50.2 6 14519791 (1), 17449569 (1), 15810992 (1), 17577393 (1)
    phospholipid 50.1 6 7811720 (1), 18658143 (1), 1951666 (1), 14668349 (1)
    phosphatidylcholine 49 1 1951666 (1)

    Search CenterWatch for drugs/clinical trials and news about GPAM / GPAT1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GPAM gene (2 alternative transcripts): 
    NM_001244949.1  NM_020918.5  

    Unigene Cluster for GPAM:

    Glycerol-3-phosphate acyltransferase, mitochondrial
    Hs.42586  [show with all ESTs]
    Unigene Representative Sequence: NM_001244949
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000348367(uc009xxy.2 uc001kzp.3) ENST00000369425(uc001kzq.1)
    ENST00000480130 ENST00000498541 ENST00000423155

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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPAM

    Additional mRNA sequence: 

    AB046780.1 AK025752.1 AK172799.1 AL832464.1 AL833061.2 AL833093.2 BC030783.1 BX647451.1 

    9 DOTS entries:

    DT.217440  DT.100684712  DT.95138076  DT.91741764  DT.100798490  DT.91741766  DT.100798489  DT.91666113 
    DT.95189343 

    24/205 AceView cDNA sequences (see all 205):

    AI741835 AA749080 CB157467 AA642465 BQ437820 CB164736 F04204 CA432659 
    AA678235 AA133298 AI056547 AV708696 AA280759 N23554 BQ894080 AI220153 
    AI129392 N63655 AI004771 BX647451 AI074476 AI682142 BX493033 CB269165 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for GPAM (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:              -                       -                                         -                 -                                                         
    SP2:                                      -                                         -                 -                                                         
    SP3:              -                       -                                                                                                                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21 ^ 22a · 22b ^ 23 ^ 24
    SP1:              -               
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for GPAM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPAM expression in normal human tissues (normalized intensities)      GPAM embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGGACCTA
    GPAM Expression
    About this image


    GPAM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Midbrain tegmentum
             ganglion/cranial   
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Eye (Sensory Organs)
             Retina

    See GPAM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GPAM

    SOURCE GeneReport for Unigene cluster: Hs.42586
        SABiosciences Custom PCR Arrays for GPAM
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GPAM gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpam1 , 5 glycerol-3-phosphate acyltransferase, mitochondrial less1, 5 84.64(n)1
    92.87(a)1
      19 (50.81 cM)5
    147321  NM_008149.31  NP_032175.21 
     550697345 
    chicken
    (Gallus gallus)
    Aves GPAM1 glycerol-3-phosphate acyltransferase, mitochondrial less 76.18(n)
    81.62(a)
      423895  XM_421757.2  XP_421757.2 
    lizard
    (Anolis carolinensis)
    Reptilia GPAM6
    glycerol-3-phosphate acyltransferase, mitochondria...
    80(a)
    1 ↔ 1
    GL343204.1(2144030-2219860)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.153782 Xenopus laevis transcribed sequence with weak similarity to protein spQ9HCL2 (H.sapiens) PLSB_HUMAN Glycerol-3-phosphate acyltransferase, mitochondrial precursor (GPAT) less 74.48(n)    BJ063511.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gpam1 glycerol-3-phosphate acyltransferase, mitochondrial less 65.28(n)
    66.63(a)
      100332911  XM_002663977.2  XP_002664023.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG55081 CG5508 41.88(n)
    31.61(a)
      43350  NM_143340.3  NP_651597.1 
    worm
    (Caenorhabditis elegans)
    Secernentea acl-61 Protein ACL-6 43.85(n)
    31.4(a)
      178928  NM_001028598.2  NP_001023769.1 


    ENSEMBL Gene Tree for GPAM (if available)
    TreeFam Gene Tree for GPAM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GPAM gene
    GNPAT2  GPAT22  
    5 SIMAP similar genes for GPAM using alignment to 3 protein entries:     GPAT1_HUMAN (see all proteins):
    DKFZp451B1115    GNPAT    FLJ00202    LOC150763    GPAT2

    GPAM for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/807 SNPs in GPAM are shown (see all 807)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2004135381,2
    --107573820(+) CAAAC-/AAAAAA 2 -- us2k10--------
    rs776135551,2
    C,F--107573822(+) AAACAA/GAAAAA 2 -- us2k12Minor allele frequency- G:0.08WA 120
    rs1403752611,2
    --113909131(+) GCACAC/TGTTTA 2 -- int10--------
    rs27927411,2
    C,F,H--113909284(-) TTTCTC/TCACTA 2 -- int15Minor allele frequency- T:0.01NS EA WA 536
    rs29009421,2
    C,F,A,H--113909313(+) AATATA/GTAAAA 2 -- int17Minor allele frequency- G:0.42NA WA EA 366
    rs1454616731,2
    --113909389(+) GAATAC/TTTACT 2 -- int10--------
    rs1831747451,2
    --113909468(+) TGTGGG/TTCAAT 2 -- int10--------
    rs1155741571,2
    C--113909493(+) CTGTAA/GGTTCA 2 -- int10--------
    rs27927401,2
    C,F,H--113909518(-) CTTAAC/TGATAC 2 -- int113Minor allele frequency- T:0.02NS EA NA WA 1528
    rs1904791851,2
    --113909536(+) ATAAGC/TTGCTA 2 -- int10--------

    HapMap Linkage Disequilibrium report for GPAM (113909622 - 113975135 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GPAM:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508608CNV Loss20534489
    nsv831989CNV Gain17160897
    nsv7211OTHER Inversion18451855


    Human Gene Mutation Database (HGMD): GPAM
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602395    OMIM disorders: --

    12 diseases for GPAM:    About MalaCards
    esophageal adenocarcinoma    insulin resistance    obesity    hypoxia
    diabetes mellitus    tuberculosis    alzheimer's disease    esophagitis
    adenocarcinoma    hepatitis    prostatitis    breast cancer


    GPAM for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for GPAM gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty liver 42.2 1 18658143 (1)
    obesity 24.4 3 18658143 (1), 15134282 (1)
    insulin resistance 10.6 4 15134282 (2), 18658143 (1)

    Genetic Association Database (GAD): GPAM
    Human Genome Epidemiology (HuGE) Navigator: GPAM (7 documents)

    Export disorders for GPAM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GPAM gene, integrated from 9 sources (see all 83):
    (articles sorted by number of sources associating them with GPAM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. (PubMed id 18238778)1, 2, 9 Chen Y.Q.... Cao G. (2008)
    3. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    4. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    5. Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (2010)
    6. Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. (PubMed id 19209188)1, 4 Reiling E....Dekker J.M. (2009)
    7. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (2008)
    8. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    10. Expression and identification of p90 as the murine mitochondrial glycerol-3-phosphate acyltransferase. (PubMed id 8369314)1, 3 Yet S.F....Sul H.S. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57678 HGNC: 24865 AceView: GPAM Ensembl:ENSG00000119927 euGenes: HUgn57678
    ECgene: GPAM Kegg: 57678 H-InvDB: GPAM

    (According to HUGE)
    About This Section
    HUGE: KIAA1560

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPAM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GPAM gene:
    Search GeneIP for patents involving GPAM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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