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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GPAM Gene

protein-coding GIFtS: 59
GCID: GC10M113899

glycerol-3-phosphate acyltransferase, mitochondrial

Explore 12 diseases affiliated with
GPAM via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Glycerol-3-Phosphate Acyltransferase, Mitochondrial¹ ²		MGC26846¹
GPAT1¹ ² ³		GPAT²
KIAA1560¹ ³		Glycerol 3-Phosphate Acyltransferase, Mitochondrial²
GPAT-1² ³		Glycerol-3-Phosphate Acyltransferase 1, Mitochondrial²
EC 2.3.1.15³ ⁸		EC 2.3.1⁸

External Ids:	HGNC: 24865¹	Entrez Gene: 57678²	Ensembl: ENSG00000119927⁷	OMIM: 602395⁵	UniProtKB: Q9HCL2³

Export aliases for GPAM gene to outside databases

Previous GC identifers: GC10U990097 GC10M113575 GC10M107537

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GPAM:

This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of

glycerolipids. This metabolic pathway's first step is catalyzed by the encoded enzyme. Two forms for this enzyme

exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript variants

have been described for this gene. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: GPAT1_HUMAN, Q9HCL2

Function: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in

glycerolipid biosynthesis

Gene Wiki entry for GPAM

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GPAM gene promoter:
Max1 FOXO3 Pax-2 Pax-2a HNF-3beta LCR-F1 GATA-2 Pax-2b ZIC2/Zic2 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GPAM promoter sequence

Search SABiosciences Chromatin IP Primers for GPAM

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPAM

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.2 Ensembl cytogenetic band: 10q25.2 HGNC cytogenetic band: 10q25.3

GPAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPAM gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M113899: view genomic region (about GC identifiers)

Start:	113,909,622 bp from pter	End:	113,975,135 bp from pter
Size:	65,514 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GPAT1_HUMAN, Q9HCL2 (See protein sequence)

Recommended Name: Glycerol-3-phosphate acyltransferase 1, mitochondrial precursor

Size: 828 amino acids; 93795 Da

Subcellular location: Mitochondrion outer membrane; Multi-pass membrane protein (By similarity)

Secondary accessions: Q5VW51 Q86TA3

Explore the universe of human proteins at neXtProt for GPAM: NX_Q9HCL2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HCL2

4/9 DME Specific Peptides for GPAM (Q9HCL2) (see all 9)

HRSHIDY

RPFVGRCC

FLEGTRSR

GTIDVSYLP

GPAM Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001231878.1 NP_065969.3

ENSEMBL proteins:

ENSP00000265276 ENSP00000358433 ENSP00000409242

Reactome Protein details: Q9HCL2
Human Recombinant Protein Products for GPAM:

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	Uscn Proteins for GPAM

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	--	--
GO:0005741	mitochondrial outer membrane	TAS	--
GO:0005743	mitochondrial inner membrane	IEA	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	IEA	--

GPAM for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GPAM for domains About GeneDecksing

2 InterPro domains/families:

IPR022284 G3P_O-AcylTrfase

IPR002123 Plipid/glycerol_acylTrfase

Graphical View of Domain Structure for InterPro Entry Q9HCL2

ProtoNet protein and cluster: Q9HCL2

1 Blocks protein family: IPB002123 Phospholipid/glycerol acyltransferase

UniProtKB/Swiss-Prot: GPAT1_HUMAN, Q9HCL2

Domain: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the

phosphate moiety of the glycerol-3-phosphate (By similarity)

Similarity: Belongs to the GPAT/DAPAT family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: GPAT1_HUMAN, Q9HCL2

Function: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in

glycerolipid biosynthesis

Catalytic activity: Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate

Enzyme Numbers (IUBMB): EC 2.3.1.15¹ ² EC 2.3.1²

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004366	glycerol-3-phosphate O-acyltransferase activity	IMP	18238778

GPAM for ontologies About GeneDecksing

Phenotypes:
5 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Gpam):

adipose tissue

growth/size

homeostasis/metabolism

liver/biliary system

no phenotypic analysis

GPAM for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for GPAM: Gpam^tm1Rcol Gpam^tm1Lex

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for GPAM

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		hsa-miR-607 hsa-miR-29a hsa-miR-128 hsa-miR-218 hsa-miR-105 hsa-miR-570 hsa-miR-183* hsa-miR-9

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPAM

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

CDP-diacylglycerol biosynthesis I

	CDP-diacylglycerol biosynthesis I	1.00			triacylglycerol biosynthesis	0.50
	phosphatidylglycerol biosynthesis II (non-plastidic)	0.94			Triacylglyceride Synthesis	0.17

Regulation of Cholesterol Biosynthesis by SREBP (SREBF)

	Regulation of Cholesterol Biosynthesis by SREBP (SREBF)	1.00			SREBP signalling	0.46
	Activation of Gene Expression by SREBP (SREBF)	0.67

Glycerophospholipid biosynthesis

	Glycerophospholipid biosynthesis	1.00			Glycerophospholipid metabolism	0.54
	Phospholipid metabolism	0.64

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Metformin Pathway, Pharmacodynamic

Metformin Pathway, Pharmacodynamic

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 BioSystems Pathways for GPAM (see all 6)

	SREBP signalling
	CDP-diacylglycerol biosynthesis I
	Validated targets of C-MYC transcriptional activation
	Triacylglyceride Synthesis
	phosphatidylglycerol biosynthesis II (non-plastidic)

5/10 Reactome Pathways for GPAM (see all 10)

	Synthesis of PA
	Metabolism
	Phospholipid metabolism
	Triglyceride Biosynthesis
	Fatty acid, triacylglycerol, and ketone body metabolism

1 PharmGKB Pathway for GPAM

Metformin Pathway, Pharmacodynamic

3 Kegg Pathways (Kegg details for GPAM):

	Glycerolipid metabolism
	Glycerophospholipid metabolism
	Metabolic pathways

UniProtKB/Swiss-Prot: GPAT1_HUMAN, Q9HCL2

Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate:

step 1/3

GPAM for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GPAM

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/31 Interacting proteins for GPAM (ENSP00000265276⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 31)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AGPAT2	ENSP00000360761⁴	STRING: ENSP00000360761
AGPAT3	ENSP00000291572⁴	STRING: ENSP00000291572
AGPAT4	ENSP00000314036⁴	STRING: ENSP00000314036
AGPAT5	ENSP00000285518⁴	STRING: ENSP00000285518
AGPAT6	ENSP00000380184⁴	STRING: ENSP00000380184

About this table

Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006631	fatty acid metabolic process	IEA	--
GO:0006637	acyl-CoA metabolic process	IEA	--
GO:0006641	triglyceride metabolic process	--	--
GO:0006644	phospholipid metabolic process	TAS	--
GO:0006650	glycerophospholipid metabolic process	--	--

GPAM for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GPAM for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GPAM

10/33 HMDB Compounds for GPAM (see all 33) About this table

Compound	Synonyms	CAS #	PubMed Ids
(2E)-Decenoyl-CoA	(E)-S-2-decenoate Coenzyme A (see all 15)	10018-95-8	--
(2E)-Dodecenoyl-CoA	2-trans-Dodecenoyl-Coenzyme A (see all 4)	1066-12-2	--
(2E)-Hexadecenoyl-CoA	trans-2-Hexadecenoyl-CoA (see all 4)	4460-95-1	--
(2E)-Octenoyl-CoA	(E)-S-2-octenoate Coenzyme A (see all 16)	10018-94-7	--
(2E)-Tetradecenoyl-CoA	(2E)-Tetradecenoyl-Coenzyme A (see all 8)	38795-33-4	--
2-Methylbutyryl-CoA	2-methylbutanoyl-CoA (see all 11)	6712-02-3	--
2-Methylhexanoyl-CoA	2-Methylhexanoyl-CoEnzyme A (see all 5)	--	--
3Z-dodecenoyl-CoA	S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)	2152-91-2	--
Acetyl-CoA	S-Acetyl coenzyme A (see all 13)	72-89-9	--
Acrylyl-CoA	Acryloyl coenzyme A (see all 14)	5776-58-9	--

10/13 Novoseek chemical compound relationships for GPAM gene (see all 13) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glycerol 3-phosphate	94.6	87	14668349 (3), 18238778 (3), 2176832 (2), 11399150 (2) (see all 44)
triacylglycerol	79.7	19	16864897 (2), 17170135 (2), 19336658 (1), 9706228 (1) (see all 12)
phosphatidate	73.6	1	19336658 (1)
acyl-coa	71.5	4	8463874 (1), 9452481 (1), 15175356 (1)
dhap	65.8	3	16423830 (1), 19720088 (1)
fatty acid	62	14	9706228 (2), 17066326 (1), 14519791 (1), 17005995 (1) (see all 9)
sterol	61	5	9054427 (2), 17577393 (1)
acetyl-coa	50.2	6	14519791 (1), 17449569 (1), 15810992 (1), 17577393 (1)
phospholipid	50.1	6	7811720 (1), 18658143 (1), 1951666 (1), 14668349 (1)
phosphatidylcholine	49	1	1951666 (1)

Search CenterWatch for drugs/clinical trials and news about GPAM / GPAT1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GPAM gene (2 alternative transcripts):

NM_001244949.1 NM_020918.5

Unigene Cluster for GPAM:

Glycerol-3-phosphate acyltransferase, mitochondrial

Hs.42586 [show with all ESTs]

Unigene Representative Sequence: NM_001244949

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000348367(uc009xxy.2 uc001kzp.3) ENST00000369425(uc001kzq.1)

ENST00000480130 ENST00000498541 ENST00000423155

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Additional cDNA sequence:

AB046780.1 AK025752.1 AK172799.1 AL832464.1 AL833061.2 AL833093.2 BC030783.1 BX647451.1

9 DOTS entries:

DT.217440 DT.100684712 DT.95138076 DT.91741764 DT.100798490 DT.91741766 DT.100798489 DT.91666113

DT.95189343

24/205 AceView cDNA sequences (see all 205):

CA432659 N63655 AA642465 CB164736 CB321947 BM837295 AI682142 AV708696

AA749080 AI017175 N79900 AA721183 AA280759 BQ894080 AA337699 AI741835

CB157467 N23554 Z45308 AI160381 AI056547 BQ694370 AI004771 R86112

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for GPAM (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^
SP1:					-								-														-						-
SP2:													-														-						-
SP3:					-								-
SP4:
SP5:

ExUns:	21	^	22a	·	22b	^	23	^	24
SP1:					-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for GPAM

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GPAM expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAGGACCTA

About this image

GPAM expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Brain

Liver

Diencephalic Ventricular Zone

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

White adipocyte-like cells (Differentiation of ...)

Adipose

See GPAM Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GPAM

SOURCE GeneReport for Unigene cluster: Hs.42586

SABiosciences Custom PCR Arrays for GPAM

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for GPAM gene from 8/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gpam^{1 , 5}	glycerol-3-phosphate acyltransferase, mitochondrial^{1, 5}	84.64(n)¹ 92.87(a)¹		19 (50.81 cM)⁵ 14732¹ NM_008149.3¹ NP_032175.2¹ 55069734⁵
chicken (Gallus gallus)	Aves	GPAM¹	glycerol-3-phosphate acyltransferase, mitochondrial	76.18(n) 81.62(a)		423895 XM_421757.2 XP_421757.2
lizard (Anolis carolinensis)	Reptilia	GPAM⁶	--	80(a)	1 ↔ 1	GL343204.1(2159653-2215134)
African clawed frog (Xenopus laevis)	Amphibia	Xl.15378²	Xenopus laevis transcribed sequence with weak similarity more	74.48(n)		BJ063511.1
zebrafish (Danio rerio)	Actinopterygii	gpam¹	glycerol-3-phosphate acyltransferase, mitochondrial	65.28(n) 66.63(a)		100332911 XM_002663977.2 XP_002664023.2
fruit fly (Drosophila melanogaster)	Insecta	CG5508¹	CG5508	41.88(n) 31.61(a)		43350 NM_143340.3 NP_651597.1
worm (Caenorhabditis elegans)	Secernentea	acl-6¹	Protein ACL-6	43.85(n) 31.4(a)		178928 NM_001028598.2 NP_001023769.1
E. coli (Escherichia coli)	Gamma proteobacteria	plsB⁶	glycerol-3-phosphate O-acyltransferase	17(a)	1 → many	Chromosome(4252066-4254489)

ENSEMBL Gene Tree for GPAM (if available)
TreeFam Gene Tree for GPAM (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GPAM gene

GNPAT² GPAT2²

5 SIMAP similar genes for GPAM using alignment to 3 protein entries: GPAT1_HUMAN (see all proteins):

DKFZp451B1115 GNPAT FLJ00202 LOC150763 GPAT2

GPAM for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140375261^1,2		--	113909131(+)	`GCACAC/TGTTTA`	2	--	int¹		0	--	--	--	--
rs2792741^1,2	H	--	113909284(-)	`TTTCTC/TCACTA`	2	--	int¹		5		NS EA WA	536
rs2900942^1,2	C,F,A,H	--	113909313(+)	`AATATA/GTAAAA`	2	--	int¹		7		NA WA EA	366
rs145461673^1,2		--	113909389(+)	`GAATAC/TTTACT`	2	--	int¹		0	--	--	--	--
rs183174745^1,2		--	113909468(+)	`TGTGGG/TTCAAT`	2	--	int¹		0	--	--	--	--
rs115574157^1,2	C	--	113909493(+)	`CTGTAA/GGTTCA`	2	--	int¹		0	--	--	--	--
rs2792740^1,2	C,F,H	--	113909518(-)	`CTTAAC/TGATAC`	2	--	int¹		13		NS EA NA WA	1528
rs190479185^1,2		--	113909536(+)	`ATAAGC/TTGCTA`	2	--	int¹		0	--	--	--	--
rs182716782^1,2		--	113909565(+)	`TAATTA/GTTCGT`	2	--	int¹		0	--	--	--	--
rs138008636^1,2		--	113909774(+)	`TTCACA/GAGTCT`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GPAM (113909622 - 113975135 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GPAM: --
Human Gene Mutation Database (HGMD): GPAM

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPAM

DNA2.0 Custom Variant and Variant Library Synthesis for GPAM

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GPAM for disorders           About GeneDecksing

OMIM gene information: 602395    OMIM disorders: --

12 diseases for GPAM:    About MalaCards

insulin resistance diabetes mellitus obesity alzheimer's disease

esophagitis cholesterol hypoxia tuberculosis

adenocarcinoma hepatitis prostatitis mycobacterium tuberculosis

3 Novoseek disease relationships for GPAM gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fatty liver	42.2	1	18658143 (1)
obesity	24.4	3	18658143 (1), 15134282 (1)
insulin resistance	10.6	4	15134282 (2), 18658143 (1)

Human Genome Epidemiology (HuGE) Navigator: GPAM (7 documents)

Export disorders for GPAM gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GPAM gene, integrated from 9 sources (see all 82):
(articles sorted by number of sources associating them with GPAM)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)^{1, 2, 3} Nagase T.... Ohara O. (2000)
AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. (PubMed id 18238778)^{1, 2, 9} Chen Y.Q.... Cao G. (2008)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (2004)
Expression and identification of p90 as the murine mitochondrial glycerol-3-phosphate acyltransferase. (PubMed id 8369314)^{1, 3} Yet S.F....Sul H.S. (1993)
Identification and functional characterization of huma n glycerol-3-phosphate acyltransferase 1 gene promoters. (PubMed id 22634312)¹ Harada N....Nakaya Y. (2012)
Integration of metabolomics and expression of glycerol -3-phosphate acyltransferase (GPAM) in breast cancer-link to patient survival, h ormone receptor status, and metabolic profiling. (PubMed id 22070544)¹ Brockmoller S.F....Denkert C. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)¹ Liu C.Y....Christiani D.C. (2010)
Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57678	HGNC: 24865	AceView: GPAM	Ensembl:ENSG00000119927	euGenes: HUgn57678
ECgene: GPAM	Kegg: 57678	H-InvDB: GPAM

(According to HUGE)
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HUGE: KIAA1560

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GPAM	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GPAM gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GPAM gene:
Search GeneIP for patents involving GPAM

GeneCards and IP:
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glycerol-3-phosphate acyltransferase, mitochondrial

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glycerol-3-phosphate acyltransferase, mitochondrial

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