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Aliases for GPALPP1 Gene

Aliases for GPALPP1 Gene

  • GPALPP Motifs Containing 1 2 3 5
  • KIAA1704 2 3 4
  • Lipopolysaccharide-Specific Response Protein 7 3 4
  • LSR7 3 4
  • Lipopolysaccharide Specific Response-7 Protein 3
  • GPALPP Motifs-Containing Protein 1 3
  • BA245H20.2 3
  • AD029 3

External Ids for GPALPP1 Gene

Previous HGNC Symbols for GPALPP1 Gene

  • KIAA1704

Previous GeneCards Identifiers for GPALPP1 Gene

  • GC13P045564

Summaries for GPALPP1 Gene

GeneCards Summary for GPALPP1 Gene

GPALPP1 (GPALPP Motifs Containing 1) is a Protein Coding gene.

Additional gene information for GPALPP1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPALPP1 Gene

Genomics for GPALPP1 Gene

Regulatory Elements for GPALPP1 Gene

Enhancers for GPALPP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H044712 1.7 FANTOM5 Ensembl ENCODE dbSUPER 42.7 -275.1 -275096 3 ZFP64 RAD21 ZNF354C FOS RCOR1 ZNF202 ZNF680 ZC3H11A CEBPB REST GPALPP1 COG3 ERICH6B RN7SL49P TPT1-AS1 RCN1P2 SMARCE1P5 CCDC122 KCTD4 GC13P044709
GH13H044917 2 FANTOM5 Ensembl ENCODE dbSUPER 20 -71.1 -71129 2 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 ZNF766 CBX5 RCN1P2 GPALPP1 RN7SL49P TPT1-AS1 COG3 NUFIP1 TSC22D1 ERICH6B KCTD4 TRE-TTC2-1
GH13H044810 0.7 Ensembl 46.1 -179.2 -179229 0 NFIA NFIB ZNF473 ZNF571 ZIK1 ZNF195 ZNF662 ZNF491 NFIC LCORL GPALPP1 TPT1-AS1 RCN1P2 RN7SL49P COG3 ERICH6B NUFIP1 CCDC122 LINC00330 LOC105370187
GH13H044270 1.7 FANTOM5 Ensembl ENCODE dbSUPER 16.3 -715.8 -715812 6 GTF2F1 TBP ATF1 IRF2 CEBPG RAD21 ZIC2 YY1 FOSL1 ZNF316 GPALPP1 NUFIP1 SERP2 SMIM2-AS1 LACC1 CCDC122 GC13M044260 GC13M044319
GH13H044155 1.2 Ensembl ENCODE dbSUPER 19.7 -833.4 -833447 1 PKNOX1 INSM2 ZNF76 KLF17 FEZF1 ZNF2 ZNF324 ZFHX2 PRDM10 EGR2 GPALPP1 SMIM2-AS1 SMIM2-IT1 LINC00390
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPALPP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPALPP1 Gene

Chromosome:
13
Start:
44,989,529 bp from pter
End:
45,037,669 bp from pter
Size:
48,141 bases
Orientation:
Plus strand

Genomic View for GPALPP1 Gene

Genes around GPALPP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPALPP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPALPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPALPP1 Gene

Proteins for GPALPP1 Gene

  • Protein details for GPALPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXQ4-GPAM1_HUMAN
    Recommended name:
    GPALPP motifs-containing protein 1
    Protein Accession:
    Q8IXQ4
    Secondary Accessions:
    • A8K8X8
    • Q05BX8
    • Q05D87
    • Q5T3Z3
    • Q5T3Z5
    • Q9C0F9
    • Q9H2R0
    • Q9P0W6

    Protein attributes for GPALPP1 Gene

    Size:
    340 amino acids
    Molecular mass:
    38142 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH17776.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB21795.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for GPALPP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPALPP1 Gene

Post-translational modifications for GPALPP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GPALPP1 Gene

Domains & Families for GPALPP1 Gene

Gene Families for GPALPP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GPALPP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPALPP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GPALPP1: view

No data available for UniProtKB/Swiss-Prot for GPALPP1 Gene

Function for GPALPP1 Gene

Phenotypes From GWAS Catalog for GPALPP1 Gene

genes like me logo Genes that share phenotypes with GPALPP1: view

Animal Model Products

CRISPR Products

miRNA for GPALPP1 Gene

miRTarBase miRNAs that target GPALPP1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GPALPP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPALPP1 Gene

Localization for GPALPP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPALPP1 gene
Compartment Confidence
golgi apparatus 3
nucleus 2
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GPALPP1 Gene

Pathways & Interactions for GPALPP1 Gene

SuperPathways for GPALPP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPALPP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GPALPP1 Gene

Drugs & Compounds for GPALPP1 Gene

No Compound Related Data Available

Transcripts for GPALPP1 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GPALPP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GPALPP1 Gene

No ASD Table

Relevant External Links for GPALPP1 Gene

GeneLoc Exon Structure for
GPALPP1
ECgene alternative splicing isoforms for
GPALPP1

Expression for GPALPP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPALPP1 Gene

Protein differential expression in normal tissues from HIPED for GPALPP1 Gene

This gene is overexpressed in Liver, secretome (24.9), Peripheral blood mononuclear cells (8.7), and Blymphocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GPALPP1 Gene



Protein tissue co-expression partners for GPALPP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPALPP1 Gene:

GPALPP1

Evidence on tissue expression from TISSUES for GPALPP1 Gene

  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with GPALPP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPALPP1 Gene

Orthologs for GPALPP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPALPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPALPP1 33 34
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia GPALPP1 33 34
  • 91.18 (n)
mouse
(Mus musculus)
Mammalia Gpalpp1 33 16 34
  • 89.28 (n)
rat
(Rattus norvegicus)
Mammalia Gpalpp1 33
  • 86.18 (n)
cow
(Bos Taurus)
Mammalia GPALPP1 34
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPALPP1 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPALPP1 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPALPP1 33 34
  • 70.8 (n)
lizard
(Anolis carolinensis)
Reptilia GPALPP1 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpalpp1 33
  • 64.09 (n)
Str.15378 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5217 33
zebrafish
(Danio rerio)
Actinopterygii gpalpp1 33 34
  • 61.41 (n)
wufc50h08 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004241 33
  • 48.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG33332 33 34
  • 47.62 (n)
worm
(Caenorhabditis elegans)
Secernentea F26A3.7 33 34
  • 50.73 (n)
Species where no ortholog for GPALPP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPALPP1 Gene

ENSEMBL:
Gene Tree for GPALPP1 (if available)
TreeFam:
Gene Tree for GPALPP1 (if available)

Paralogs for GPALPP1 Gene

No data available for Paralogs for GPALPP1 Gene

Variants for GPALPP1 Gene

Sequence variations from dbSNP and Humsavar for GPALPP1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000050975 -- 45,020,678(+) TATAT(A/C)GCCTT intron-variant
rs1000129415 -- 44,994,088(+) TAGTG(C/T)ATGCC intron-variant
rs1000133887 -- 44,991,239(+) GTCGA(C/G)AGATC intron-variant, upstream-variant-2KB
rs1000151167 -- 45,028,459(+) TCAGA(A/G)TGGTG intron-variant
rs1000172769 -- 45,003,515(+) GGGAG(A/T)CTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPALPP1 Gene

Variant ID Type Subtype PubMed ID
esv2747335 CNV deletion 23290073
esv2747336 CNV deletion 23290073
esv3631945 CNV gain 21293372
nsv475833 CNV novel sequence insertion 20440878
nsv64787 CNV insertion 16902084

Variation tolerance for GPALPP1 Gene

Residual Variation Intolerance Score: 74.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPALPP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPALPP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPALPP1 Gene

Disorders for GPALPP1 Gene

Relevant External Links for GPALPP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPALPP1

No disorders were found for GPALPP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPALPP1 Gene

Publications for GPALPP1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 60
  2. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for GPALPP1 Gene

Sources for GPALPP1 Gene

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