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Aliases for GPA33 Gene

Aliases for GPA33 Gene

  • Glycoprotein A33 2 3 4
  • Glycoprotein A33 (Transmembrane) 2 3 5
  • Transmembrane Glycoprotein A33 3
  • A33 3

External Ids for GPA33 Gene

Previous GeneCards Identifiers for GPA33 Gene

  • GC01M164656
  • GC01M162672
  • GC01M163718
  • GC01M164209
  • GC01M163753
  • GC01M165288
  • GC01M138268

Summaries for GPA33 Gene

Entrez Gene Summary for GPA33 Gene

  • The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPA33 Gene

GPA33 (Glycoprotein A33) is a Protein Coding gene. Diseases associated with GPA33 include infant botulism and foodborne botulism. GO annotations related to this gene include receptor activity. An important paralog of this gene is CXADR.

UniProtKB/Swiss-Prot for GPA33 Gene

  • May play a role in cell-cell recognition and signaling.

Gene Wiki entry for GPA33 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPA33 Gene

Genomics for GPA33 Gene

Regulatory Elements for GPA33 Gene

Genomic Location for GPA33 Gene

Chromosome:
1
Start:
167,052,836 bp from pter
End:
167,166,479 bp from pter
Size:
113,644 bases
Orientation:
Minus strand

Genomic View for GPA33 Gene

Genes around GPA33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPA33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPA33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPA33 Gene

Proteins for GPA33 Gene

  • Protein details for GPA33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99795-GPA33_HUMAN
    Recommended name:
    Cell surface A33 antigen
    Protein Accession:
    Q99795
    Secondary Accessions:
    • Q5VZP6

    Protein attributes for GPA33 Gene

    Size:
    319 amino acids
    Molecular mass:
    35632 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPA33 Gene

Proteomics data for GPA33 Gene at MOPED

Post-translational modifications for GPA33 Gene

Other Protein References for GPA33 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GPA33 Gene

Domains & Families for GPA33 Gene

Suggested Antigen Peptide Sequences for GPA33 Gene

Graphical View of Domain Structure for InterPro Entry

Q99795

UniProtKB/Swiss-Prot:

GPA33_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with GPA33: view

Function for GPA33 Gene

Molecular function for GPA33 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cell-cell recognition and signaling.
genes like me logo Genes that share phenotypes with GPA33: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPA33

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPA33 Gene

Localization for GPA33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPA33 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPA33 Gene COMPARTMENTS Subcellular localization image for GPA33 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GPA33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005911 cell-cell junction IBA --
genes like me logo Genes that share ontologies with GPA33: view

Pathways & Interactions for GPA33 Gene

SuperPathways for GPA33 Gene

No Data Available

Interacting Proteins for GPA33 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356842%0d%0a9606.ENSP00000350249%0d%0a
Selected Interacting proteins: ENSP00000356842 Q99795-GPA33_HUMAN for GPA33 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for GPA33 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GPA33 Gene

Drugs & Compounds for GPA33 Gene

(1) Drugs for GPA33 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
KRN-330 Pharma 0
genes like me logo Genes that share compounds with GPA33: view

Transcripts for GPA33 Gene

Unigene Clusters for GPA33 Gene

Glycoprotein A33 (transmembrane):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPA33 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2:

Relevant External Links for GPA33 Gene

GeneLoc Exon Structure for
GPA33
ECgene alternative splicing isoforms for
GPA33

Expression for GPA33 Gene

mRNA expression in normal human tissues for GPA33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPA33 Gene

This gene is overexpressed in Colon - Transverse (x37.2) and Small Intestine - Terminal Ileum (x11.9).

Protein differential expression in normal tissues from HIPED for GPA33 Gene

This gene is overexpressed in Rectum (36.7) and Colon (25.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GPA33 Gene



SOURCE GeneReport for Unigene cluster for GPA33 Gene Hs.651244

mRNA Expression by UniProt/SwissProt for GPA33 Gene

Q99795-GPA33_HUMAN
Tissue specificity: Expressed in normal gastrointestinal epithelium and in 95% of colon cancers.
genes like me logo Genes that share expression patterns with GPA33: view

Protein tissue co-expression partners for GPA33 Gene

Primer Products

In Situ Assay Products

Orthologs for GPA33 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPA33 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPA33 35
  • 79.09 (n)
  • 72.61 (a)
GPA33 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPA33 35
  • 81.1 (n)
  • 75.8 (a)
GPA33 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpa33 35
  • 76.58 (n)
  • 66.77 (a)
Gpa33 16
Gpa33 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPA33 35
  • 98.64 (n)
  • 97.49 (a)
GPA33 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpa33 35
  • 76.79 (n)
  • 68.67 (a)
oppossum
(Monodelphis domestica)
Mammalia GPA33 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPA33 35
  • 55.51 (n)
  • 46.92 (a)
GPA33 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPA33 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpa33 35
  • 53.85 (n)
  • 45.93 (a)
MGC75653 35
zebrafish
(Danio rerio)
Actinopterygii LOC101885644 35
  • 47.66 (n)
  • 37.87 (a)
gpa33 36
  • 21 (a)
OneToMany
GPA33 (1 of 2) 36
  • 24 (a)
OneToMany
Species with no ortholog for GPA33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPA33 Gene

ENSEMBL:
Gene Tree for GPA33 (if available)
TreeFam:
Gene Tree for GPA33 (if available)

Paralogs for GPA33 Gene

(3) SIMAP similar genes for GPA33 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPA33: view

Variants for GPA33 Gene

Sequence variations from dbSNP and Humsavar for GPA33 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2274531 - 167,073,525(-) CCGTC(A/G)ATGCC reference, missense
VAR_049874 -
rs1041237 -- 167,069,699(-) CATGG(C/G)AGAAT intron-variant
rs2312489 -- 167,071,551(+) CAGAC(A/C)AGGTT intron-variant
rs6699306 -- 167,074,025(+) TTTGT(A/C)TGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPA33 Gene

Variant ID Type Subtype PubMed ID
esv2750815 CNV Gain 17911159
esv2649114 CNV Insertion 19546169
esv1004965 CNV Deletion 20482838

Variation tolerance for GPA33 Gene

Residual Variation Intolerance Score: 80.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPA33 Gene

HapMap Linkage Disequilibrium report
GPA33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPA33 Gene

Disorders for GPA33 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPA33 Gene - From: DISEASES

Disorder Aliases PubMed IDs
infant botulism
  • infant intestinal botulism
foodborne botulism
  • intoxication botulism
- elite association - COSMIC cancer census association via MalaCards
Search GPA33 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPA33

Genetic Association Database (GAD)
GPA33
Human Genome Epidemiology (HuGE) Navigator
GPA33
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPA33
genes like me logo Genes that share disorders with GPA33: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPA33 Gene

Publications for GPA33 Gene

  1. Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium. (PMID: 9245713) Ritter G. … Simpson R.J. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23 67
  2. The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily. (PMID: 9012807) Heath J.K. … Burgess A.W. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 23
  3. Two distinct populations of exosomes are released from LIM1863 colon carcinoma cell-derived organoids. (PMID: 23230278) Tauro B.J. … Simpson R.J. (Mol. Cell Proteomics 2013) 3
  4. Safety, pharmacokinetics and pharmacodynamics of the anti-A33 fully-human monoclonal antibody, KRN330, in patients with advanced colorectal cancer. (PMID: 23294608) Infante J.R. … Berlin J.D. (Eur. J. Cancer 2013) 3
  5. Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. (PMID: 23898208) Johnson T.P. … Nath A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3

Products for GPA33 Gene

Sources for GPA33 Gene

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