Aliases for GP9 Gene
External Ids for GP9 Gene
Previous GeneCards Identifiers for GP9 Gene
This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. [provided by RefSeq, Oct 2008]
GeneCards Summary for GP9 Gene
GP9 (Glycoprotein IX Platelet) is a Protein Coding gene. Diseases associated with GP9 include Bernard-Soulier Syndrome, Type C and Thrombocytopenia. Among its related pathways are Hematopoietic cell lineage and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is GP1BB.
UniProtKB/Swiss-Prot for GP9 Gene
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.