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GP6 Gene

protein-coding   GIFtS: 61
GCID: GC19M055525

Glycoprotein VI (Platelet)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glycoprotein VI (Platelet)1 2     GPIV2 5
Glycoprotein 62 3     Platelet Collagen Receptor2
GPVI2 3     Platelet Glycoprotein VI2
BDPLT112 5     

External Ids:    HGNC: 143881   Entrez Gene: 512062   Ensembl: ENSG000000880537   OMIM: 6055465   UniProtKB: Q9HCN63   

Export aliases for GP6 gene to outside databases

Previous GC identifers: GC19M056387 GC19M055949 GC19M060201 GC19M060216 GC19M051846


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GP6 Gene:
This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a
receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation.
The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation
signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11
(BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
(provided by RefSeq, Dec 2011)

GeneCards Summary for GP6 Gene:
GP6 (glycoprotein VI (platelet)) is a protein-coding gene. Diseases associated with GP6 include cervix uteri carcinoma in situ, and chronic cervicitis. GO annotations related to this gene include collagen binding and receptor activity. An important paralog of this gene is LILRB4.

UniProtKB/Swiss-Prot: GPVI_HUMAN, Q9HCN6
Function: Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in
platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may
contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src
kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2

Gene Wiki entry for GP6 (GPVI) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  NT_187693.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the GP6 gene promoter:
         HOXA9B   HOXA9   Sp1   NRSF form 1   AP-4   NRSF form 2   GATA-1   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGP6 promoter sequence
   Search Chromatin IP Primers for GP6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

GP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GP6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M055525:  view genomic region     (about GC identifiers)

Start:
55,525,073 bp from pter      End:
55,549,632 bp from pter
Size:
24,560 bases      Orientation:
minus strand

Selected alternative locations (see all 8):
Chr19-,NW_003571056 993,690-1,018,249      Chr19-,NW_003571059 932,069-956,628      Chr19-,NW_003571057 1,021,227-1,045,786     
Chr19-,NW_003571058 995,776-1,020,335      Chr19-,NW_003571054 917,103-941,662      Chr19-,NW_003571055 658,906-683,465     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GPVI_HUMAN, Q9HCN6 (See protein sequence)
Recommended Name: Platelet glycoprotein VI precursor  
Size: 339 amino acids; 36866 Da
Subunit: Associated with Fc receptor gamma chain. The GPVI-FcRgamma complex is associated with the Src kinase
family Fyn and Lyn
1 PDB 3D structure from and Proteopedia for GP6:
2GI7 (3D)    
Secondary accessions: Q9HCN7 Q9UIF2
Alternative splicing: 3 isoforms:  Q9HCN6-1   Q9HCN6-2   Q9HCN6-3   (Has no transmembrane domain. Does not interact with Fc receptor gamma chain. Does not bind to collagen-like peptides. Ref.1 (BAB12247) sequence is in conflict in positions: 314:P->A, 323:K->T, 573:R->G, 606:F->L)

Explore the universe of human proteins at neXtProt for GP6: NX_Q9HCN6

Explore proteomics data for GP6 at MOPED

Post-translational modifications: 

  • N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal
    adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type
    lectin convulxin (CVX)1
  • Glycosylation2 at Asn92
  • Modification sites at PhosphoSitePlus

  • See GP6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001077368.2  NP_001242946.2  NP_057447.5  

    ENSEMBL proteins: 
     ENSP00000394922   ENSP00000308782   ENSP00000334552   ENSP00000464922  
    Reactome Protein details: Q9HCN6

    GP6 Human Recombinant Protein Products:

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    GP6 Antibody Products:

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    GP6 Assay Products:

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    Cloud-Clone Corp. CLIAs for GP6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    2 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9HCN6

    ProtoNet protein and cluster: Q9HCN6

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: GPVI_HUMAN, Q9HCN6
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    GP6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPVI_HUMAN, Q9HCN6
    Function: Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in
    platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may
    contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src
    kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS11027634
    GO:0004888transmembrane signaling receptor activity TAS10822077
    GO:0005515protein binding IPI1715582
    GO:0005518collagen binding TAS11027634
         
    GP6 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gp6):
     hematopoietic system  homeostasis/metabolism 

    GP6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gp6tm1Ware for GP6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GP6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GP6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GP6

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GPVI_HUMAN, Q9HCN6: Isoform 1: Cell membrane; Single-pass membrane protein
    GPVI_HUMAN, Q9HCN6: Isoform 2: Cell membrane; Single-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    cytosol1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--

    GP6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GP6 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    2Formation of Fibrin Clot (Clotting Cascade)
    Blood Coagulation Signaling Pathways0.51
    3Focal adhesion
    ECM-receptor interaction0.31
    4CD28 co-stimulation
    GPVI-mediated activation cascade0.31
    5Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for GP6
        Blood Coagulation Signaling Pathways


    3 Reactome Pathways for GP6
        Platelet Adhesion to exposed collagen
    GPVI-mediated activation cascade
    Cell surface interactions at the vascular wall

    1 PharmGKB Pathway for GP6
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for GP6):
        ECM-receptor interaction


    GP6 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GP6
    Interactions:

        GeneGlobe Interaction Network for GP6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GP6 (Q9HCN61, 2, 3 ENSP000003087824) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM2P621582, 3MINT-17793 MINT-17795 I2D: score=1 
    CALM3P621582, 3MINT-17793 MINT-17795 I2D: score=1 
    LYNP079481, 3EBI-515278,EBI-79452 I2D: score=3 
    CALM1P621582, 3, ENSP000003494674MINT-17793 MINT-17795 I2D: score=1 STRING: ENSP00000349467
    FYNP062413, ENSP000003576564I2D: score=3 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007167enzyme linked receptor protein signaling pathway TAS9153205
    GO:0007596blood coagulation TAS--
    GO:0030168platelet activation TAS--
    GO:0050900leukocyte migration TAS--

    GP6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GP6 (GPVI)

    Selected Novoseek inferred chemical compound relationships for GP6 gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    convulxin 97.6 101 12881531 (5), 9341142 (4), 16014566 (3), 10666318 (3) (see all 43)
    lotrafiban 80.5 1 15370101 (1)
    jararhagin 74.1 12 10666318 (3), 10727949 (1), 15320694 (1)
    echicetin 71.9 2 15320694 (1)
    adp 71.7 26 15939050 (3), 15231520 (2), 17096705 (2), 12842985 (1) (see all 17)
    tyrosine 64 56 14656219 (4), 9295288 (2), 10666318 (2), 20040043 (2) (see all 30)
    thromboxane a2 63.9 7 9468482 (2), 17362227 (1), 11964287 (1), 10066433 (1) (see all 5)
    fibrinogen 62 12 15934989 (1), 11722284 (1), 15231520 (1), 11964287 (1) (see all 9)
    go 6976 48 1 15583006 (1)
    ristocetin 44.5 1 17539777 (1)

    1 PharmGKB related drug/compound annotation for GP6 gene    About this table
    Drug/compound PharmGKB Annotation
    aspirinCA  



    GP6 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GP6 gene (3 alternative transcripts): 
    NM_001083899.2  NM_001256017.2  NM_016363.5  

    Unigene Cluster for GP6:

    Glycoprotein VI (platelet)
    Hs.661752  [show with all ESTs]
    Unigene Representative Sequence: NM_001083899
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000417454(uc002qik.3) ENST00000310373(uc002qil.3) ENST00000333884(uc010esq.3)
    ENST00000465648 ENST00000468239
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    Additional mRNA sequence: 

    AB035073.1 AB043819.1 AB043820.1 AB043821.1 BC069485.1 BC104832.1 BC111963.1 

    2 DOTS entries:

    DT.91715542  DT.91715543 

    Selected AceView cDNA sequences (see all 29):

    BF353862 BF353861 BF353841 BF204121 AB043819 BC069485 AA308708 BE294264 
    AB043820 AA494446 AB043821 NM_016363 BV189301 BF353858 BX283866 BF353812 
    BF353842 BF353837 BF353827 BF353843 BQ216894 AB035073 BF353835 BF205319 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GP6    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
    SP1:                          -                           
    SP2:                          -                           
    SP3:                                                      


    ECgene alternative splicing isoforms for GP6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTGCAATA
    GP6 Expression
    About this image


    GP6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)
             Mature Endothelial Cells Blood Brain Barrier
    GP6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GP6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.661752

    UniProtKB/Swiss-Prot: GPVI_HUMAN, Q9HCN6
    Tissue specificity: Megakaryocytes and platelets

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GP6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GP6 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gp61 , 5 glycoprotein 6 (platelet)1, 5 73.01(n)1
    69.55(a)1
      7 (2.52 cM)5
    2438161  NM_001163014.11  NP_001156486.11 
     43687135 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    12(a)
    1 → many
    GL343329.1(823590-844642)


    ENSEMBL Gene Tree for GP6 (if available)
    TreeFam Gene Tree for GP6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GP6 gene
    LILRB42  KIR2DL42  LILRB12  KIR2DS42  LILRA62  LILRA52  IGSF12  KIR3DL12  
    OSCAR2  NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  
    KIR3DL32  LILRA12  KIR3DS12  KIR2DL12  LILRB22  A1BG2  KIR3DL22  LILRA22  
    KIR2DL32  FCAR2  LILRB32  
    Selected SIMAP similar genes for GP6 using alignment to 2 protein entries:     GPVI_HUMAN (see all proteins) (see all similar genes):
    LILRB3    LAIR1    KIR-G1    p58    LAIR2    p140
    KIR-K36    KIR-G2    KIR-K9    KIR-K15    KIR-K3    KIR-K78
    KIR3DL1    KIR-K65    KIR-K64    FCAR    KIR-K61    KIR3DX1

    GP6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GP6 (see all 1070)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0665914
    Bleeding disorder, platelet-type 11 (BDPLT11)4--see VAR_0665912 S N mis40--------
    VAR_0665904
    Bleeding disorder, platelet-type 11 (BDPLT11)4--see VAR_0665902 R C mis40--------
    rs1445110751,2
    C--51875077(+) TGCCTC/TAGCCT 3 -- us2k10--------
    rs16544381,2
    C,F--51875096(+) GCTGGG/AACTAC 3 -- us2k12Minor allele frequency- A:0.25NA WA 4
    rs2020925271,2
    C--55526937(-) GTGTAA/GANNNN 24 -- int10--------
    rs678032291,2
    C--55531573(+) TAAAC-/CTTT  
            
    TTTTT
    3 -- int10--------
    rs1139634981,2
    F--55532029(+) TTGTGC/AATAGT 3 -- int11Minor allele frequency- A:0.00CSA 1
    rs711817281,2
    C--55532732(-) TTTTT-/TTGAGAT 24 -- int11Minor allele frequency- TT:0.00NA 2
    rs1117003101,2
    C,F--55533013(+) CCTCCC/TGAATA 3 -- int11Minor allele frequency- T:0.50NA 2
    rs1126094591,2
    C--55534213(+) CTGCTC/AAAGAA 24 -- int12Minor allele frequency- A:0.00NA CSA 2
    rs1131215511,2
    C,F--55534349(-) GAATGC/ATAATG 24 -- int14Minor allele frequency- A:0.25NA WA CSA 8
    rs786656231,2
    C,F--55534373(+) AAAAAA/CCTATA 3 -- int12Minor allele frequency- C:0.04WA 120
    rs1138178721,2
    C--55534374(-) AGTTTG/TTTTTT 24 -- int11Minor allele frequency- T:0.50NA 2
    rs1138511161,2
    C,F--55534417(-) TTTGTT/CCTGGC 24 -- int13Minor allele frequency- C:0.40NA CSA 5
    rs1122541091,2
    C--55534426(+) ATTGTT/AAGTAA 24 -- int11Minor allele frequency- A:0.50NA 2
    rs1118497151,2
    C--55538566(+) GCAGCC/TCAGGG 24 -- int11Minor allele frequency- T:0.50NA 2
    rs16544221,2
    C,F,A,H--55538699(+) ACTTCC/TTTCCC 24 -- int1 trp33Minor allele frequency- T:0.33NA 6
    rs49888701,2
    C,A--55538710(+) ACCTAC/TGGCCG 24 -- int12Minor allele frequency- T:0.00NA 4
    rs116696761,2
    C,A,H--55540742(+) tatatA/TtTttt 27 -- int10--------
    rs1129704561,2
    C--55541882(+) TATTATTAT    
       TAT
    /-
    TTTTT
    24 -- int11Minor allele frequency- -:0.00CSA 2
    rs780846351,2
    C,F--55544408(+) GGTGGG/ACTCGT 24 -- int13Minor allele frequency- A:0.50NA WA 6
    rs789539391,2
    --55544459(+) TAGACG/ACGGTG 3 -- int11Minor allele frequency- A:0.50NA 2
    rs754279221,2
    --55544467(+) GTGGAC/TTCGTT 24 -- int11Minor allele frequency- T:0.50NA 2
    rs739322781,2
    C--55544585(+) AGACAA/CGGTGG 24 -- int11Minor allele frequency- C:0.00WA 2
    rs621220211,2
    F--55545498(+) TGTATG/ATATAT 24 -- int12Minor allele frequency- A:0.50NA 6
    rs711817291,2
    C--55546113(-) GCCTTTG/-TGTGT 24 -- int11Minor allele frequency- -:0.00NA 2
    rs346942631,2
    C--55546609(+) AACTT-/AACAGG 24 -- int10--------
    rs711817301,2
    C--55546610(-) TCCTGT/-TAAGT 24 -- int11Minor allele frequency- -:0.00NA 2
    rs1128220511,2
    C,F--55547043(+) TCATGC/TCACTG 3 -- int11Minor allele frequency- T:0.50WA 2
    rs1116877791,2
    C,F--55547050(+) ACTGCG/ACTCCA 3 -- int11Minor allele frequency- A:0.50WA 2
    rs343863811,2
    C--55549076(+) TCACT-/GGCAAC 24 -- int10--------
    rs675780451,2
    C--55549078(+) ACTGCG/-AACTT 24 -- int11Minor allele frequency- -:0.00NA 2
    rs16712101,2
    C--55551077(+) cggcaC/Ggcacc 3 -- us2k10--------
    rs16544091,2
    C,F,A--55676538(+) taattG/Ttttat 3 -- ds500110Minor allele frequency- T:0.40EA NA WA 388
    rs1170038771,2
    F--55676617(+) ATCCCG/ACCTCA 3 -- ds50011Minor allele frequency- A:0.03EA 120
    rs1894948991,2
    --55676654(+) TGTGAA/GCCACT 3 -- ds50010--------
    rs783203851,2
    C--55676665(+) GTGCC-/TAGGCT 3 -- ds50011Minor allele frequency- T:0.00CSA 2
    rs16544101,2
    C,F,A,H--55676731(+) TCTGTC/TTTCTG 3 -- ds500131Minor allele frequency- T:0.47NA NS EA WA CSA 4890
    rs1806750291,2
    --55676792(+) TTCTTA/GCATTT 3 -- ds50010--------
    rs104163801,2
    C,F,A,H--55676823(+) TTCCCG/ATTCCC 3 -- ds500123Minor allele frequency- A:0.29NS EA WA NA CSA 2348
    rs1861295291,2
    C--55676871(+) CAGCCA/GTCGTC 3 -- ds50010--------
    rs1913823891,2
    --55676874(+) CCGTCA/GTCCTG 3 -- ds50010--------
    rs1814144831,2
    --55676921(+) TGACTC/TACCTA 3 -- ds50010--------
    rs16544111,2
    C,F,A,H--55676926(+) cacctC/Acctca 3 -- ds50019Minor allele frequency- A:0.29WA NA CSA EA 370
    rs16711481,2
    C,F,A,H--55676940(+) tcccaC/Aagtgc 3 -- ds500110Minor allele frequency- A:0.24NA WA CSA EA 138
    rs746715851,2
    C--55676941(+) CCCAAA/TGTGCC 3 -- ds50010--------
    rs16711491,2
    C,F,A,H--55676959(+) caggcA/Gtgagc 3 -- ds50017Minor allele frequency- G:0.25NA WA 16
    rs412758201,2
    C--55677033(+) GATGGA/GGTCTC 3 -- ut310--------
    rs1495704651,2
    --55677120(+) TACAGA/GCATGA 3 -- ut310--------
    rs1432499221,2
    C--55677126(+) CATGAG/TCCACT 3 -- ut310--------
    rs104179431,2
    C,F,H--55677255(+) TGAGAG/AGGGTG 3 -- ut31 ese318Minor allele frequency- A:0.12NS EA NA CSA WA 2149
    rs104179811,2
    C,F,A,H--55677306(+) atacaT/Gaattg 3 -- ut3111Minor allele frequency- G:0.30NA WA EA 374
    rs1868748021,2
    --55677319(+) CATATA/TTATGG 3 -- ut310--------
    rs761292191,2
    C,F--55677344(+) TTGCAG/TTACAT 3 -- ut311Minor allele frequency- T:0.05WA 118
    rs1387960441,2
    C--55677357(+) ATACAA/CCGTGC 3 -- ut310--------
    rs16711501,2
    C,F,A,H--55677415(+) GACAAG/AGTCAG 4 /L /F mis1 ut31 ese329Minor allele frequency- A:0.23MN NS EA NA WA CSA 4612
    rs28864161,2
    C,H--55677426(-) GGTGAC/TGAAGC 4 T M mis1 ut31 ese35Minor allele frequency- T:0.07NS EA WA 384
    rs1154590141,2
    C,F--55677442(+) TAGAGT/GGCAGT 4 /T /P mis1 ut311Minor allele frequency- G:0.04WA 118
    rs1903844711,2
    --55677466(+) CTCACC/TGCAAC 4 S G mis1 ut310--------
    rs104180741,2
    C,F,H--55677504(+) cccacC/Ttcagc 4 K R mis1 ut31 ese38Minor allele frequency- T:0.08NS EA NA WA 754
    rs16544121,2,,4
    C,F,A--55677514(+) CCCCCC/TGAGTT 4 R G mis1 ut31 ese313Minor allele frequency- T:0.42MN NA WA CSA EA 742
    rs2005667921,2
    C--55677681(+) ATGACA/CTACCC 4 R M mis1 ut311Minor allele frequency- C:0.00EU 1323
    rs2003991961,2
    --55677700(+) TGCAAC/GACCCG 4 L V mis1 ut310--------
    rs1420534571,2
    C--55677706(+) ACCCGC/TTCTGA 4 T A mis1 ut310--------
    rs1463186511,2
    C--55677716(+) AGAGAC/TGAAAG 4 S syn1 ut310--------
    rs412758221,2
    C,F--55677736(+) TAGACC/TGCAGT 4 S G mis1 ut311Minor allele frequency- T:0.03EU 1323
    rs1995612711,2
    --55677764(+) TGAGAA/GTTTCT 4 N syn1 ut310--------
    rs1417372561,2
    C--55677772(+) TCTGGA/GGAAAA 4 P S mis1 ut310--------
    rs16711511,2
    C,F,O,A,H--55677812(+) AGCACA/GGGAGG 4 P syn1 ut31 ese326Minor allele frequency- G:0.23MN NA NS EA WA CSA EU 5870
    rs2019405031,2
    --55677882(+) CTGGAA/GCCCAT 4 A V mis1 ut310--------
    rs746972031,2
    C,F--55677944(+) GTCATC/TCACAG 4 * W stg1 ut314Minor allele frequency- T:0.00CSA WA EU 1443
    rs1508073941,2
    C--55677987(+) TCCTTC/GCATCC 4 A G mis1 ut310--------
    rs1386805891,2
    C--55678021(+) AGAGG-/CAGA  
            
    CAGAC
    4 P SAS fra1 ut310--------
    rs591108611,2
    C--55678039(+) AGACA-/GACA  
            
    CTGGC
    4 P S fra1 ut310--------
    rs2009402601,2
    --55678040(+) AGACAC/GTGGCC 4 H Q mis1 ut310--------
    rs1829407841,2
    C--55678089(+) GGCCTC/TGTTTC 4 Q R mis1 ut310--------
    rs2000194441,2
    --55678185(+) GATACA/GACCGT 4 S L mis1 ut310--------
    rs1861032701,2
    C--55678188(+) ACGACC/TGTGCC 4 Q R mis1 ut310--------
    rs2016039061,2
    --55678208(+) GCGGTC/TATGAA 6 I M * mis1 syn10--------
    rs2009481001,2
    C--55678258(+) TGACCC/GCCGTT 6 R G mis1 syn10--------
    rs803482651,2
    C--55678260(+) ACCCCC/TGTTTG 6 Q R G mis12Minor allele frequency- T:0.00WA EU 843
    rs2004313111,2
    C--55678289(+) GGGGCA/GGGAGG 6 P L syn1 mis10--------
    rs23041661,2
    C,F,H--55678291(+) GGCGGC/GAGGGG 6 P A L mis1 syn1 ese39Minor allele frequency- G:0.48NS NA WA EA EU 809
    rs2001511531,2
    C--55678298(+) GGGGCA/GGAAGC 6 S P L syn1 mis10--------
    rs2019974101,2
    C--55678346(+) TCCTCC/TGGCTG 6 P Q R syn1 mis10--------
    rs2017532641,2
    C--55678347(+) CCTCCA/GGCTGT 6 P L R W mis10--------
    rs2014366291,2
    C--55678384(+) AGGATA/TATTAG 6 N Y I mis1 syn10--------
    rs608433021,2
    C,F--55678399(+) ACAGCC/TCCGAG 6 S G mis1 syn12Minor allele frequency- T:0.04NS WA 66
    rs1909046141,2
    C--55678402(+) GCCCCA/GAGGCA 6 R W L mis1 syn10--------
    rs2005624271,2
    --55678489(+) AAGAGC/GCCACC 3 -- int10--------
    rs1143745021,2
    F--55678550(+) CTCTAC/TTAGCT 3 -- int11Minor allele frequency- T:0.03WA 118
    rs1151079541,2
    F--55678570(+) CGCTCA/GCTTTC 3 -- int11Minor allele frequency- G:0.03WA 118
    rs455123921,2
    C,F--55678744(+) AAGGGG/CTGGGG 3 -- int14Minor allele frequency- C:0.11WA NA 126
    rs1828419081,2
    --55678750(+) TGGGGA/GAGAGA 3 -- int10--------
    rs803549441,2
    F--55678835(+) CATACG/ACTGAT 3 -- int11Minor allele frequency- A:0.03WA 118
    rs1404999501,2
    C--55678851(+) GCCTT-/TACTC 
            
    TACAC
    3 -- int10--------
    rs32173941,2
    C--55678854(+) TTTAC-/TCTAC 
            
    ACACT
    3 -- int11Minor allele frequency- TCTAC:0.00NA 2
    rs1499480901,2
    --55678886(+) AGCTGC/TAGCCC 3 -- int10--------
    rs789451481,2
    C,F--55678928(+) GAGACG/AGGTGA 3 -- int11Minor allele frequency- A:0.03WA 118
    rs23041671,2,,4
    C,F,O,A,H--55678999(+) ACTGGC/TGGTGA 6 T A mis1 ese336Minor allele frequency- N:0.00EA NA NS WA CSA EU 7283
    rs1469632101,2
    C--55679103(+) CACAC-/ATGGGGA 3 -- int10--------
    rs16711531,2
    C,F,O,A,H--55679107(+) CATGGT/GGAGGC 3 -- int124Minor allele frequency- G:0.30NA NS EA WA CSA 2134
    rs1448978681,2
    --55679139(+) AAAGCA/GTGGGC 3 -- int10--------
    rs20195991,2
    C,F--55679151(+) GGGCAC/TGGTGC 3 -- int13Minor allele frequency- T:0.09WA NA EA 358
    rs16544841,2
    C,F,A,H--55679194(+) TGAGGC/TAGGAG 3 -- int18Minor allele frequency- T:0.19NA WA 136
    rs1928875171,2
    --55679226(+) CAAGAA/CCAACC 3 -- int10--------
    rs1831239851,2
    --55679293(+) GGTGGC/TACGTG 3 -- int10--------
    rs1402480421,2
    --55679380(+) CCAGGA/GTTGTA 3 -- int10--------
    rs16544851,2
    C,F,A--55679420(+) GAGACC/ACTGTC 3 -- int15Minor allele frequency- A:0.35WA NA EA 362
    rs752221161,2
    F--55679494(+) CACCTA/GTTAGA 3 -- int11Minor allele frequency- G:0.03WA 118
    rs178365241,2
    C,F,H--55679608(+) AATAAT/CGGTAG 3 -- int19Minor allele frequency- C:0.13NA EA NS WA 774
    rs48066311,2
    C,F--55679627(+) AGCACA/CGTGCT 3 -- int111Minor allele frequency- C:0.27NA WA CSA EA 374
    rs1872576491,2
    --55679724(+) TGGCCC/GGATGT 3 -- int10--------
    rs1919841081,2
    --55679802(+) GACTAC/TAGGCG 3 -- int10--------
    rs1845404801,2
    C--55679810(+) GCGTCC/TGCCAC 3 -- int10--------
    rs1443525641,2
    --55679881(+) GGTTTC/TGAACT 3 -- int10--------
    rs1894412901,2
    --55679925(+) AAAGTA/GCTGGG 3 -- int10--------
    rs178365261,2
    C,F,H--55680025(+) GGCCAA/TGGGAA 3 -- int111Minor allele frequency- T:0.29NA NS EA WA 2942
    rs116675101,2
    C,F,A,H--55680124(+) atcacG/Ctgagg 3 -- int14Minor allele frequency- C:0.38NA 8
    rs1931389011,2
    --55680193(+) AAAAAA/TTAGCT 3 -- int10--------
    rs1169147221,2
    F--55680265(+) AGATCG/ACAGAG 3 -- int11Minor allele frequency- A:0.02NA 120
    rs16544141,2
    C,F,H--55680300(+) gtgagG/Cagagt 3 -- int113Minor allele frequency- C:0.28EA NS NA WA CSA 668
    rs16711881,2
    C,F,A--55680311(+) gagacT/Gccgtc 3 -- int19Minor allele frequency- G:0.48NA WA CSA EA 370
    rs1141148571,2
    F--55680313(+) GACTCC/TGTCTC 3 -- int11Minor allele frequency- T:0.02WA 118
    rs81066151,2
    C,F,H--55680347(+) aaaCCA/GTAAGA 3 -- int114Minor allele frequency- G:0.36EA NS NA WA CSA 802
    rs1157450181,2
    F--55680374(+) TTCCCA/GGACTA 3 -- int11Minor allele frequency- G:0.02WA 118
    rs1417849881,2
    C--55680404(+) AAAGCA/GATTTT 3 -- int10--------
    rs114335341,2
    C--55680405(+) AGCGA-/TTTTTT 3 -- int1 trp30--------
    rs592853361,2
    C--55680406(+) TTTTT-/TAATAC 3 -- int10--------
    rs1437507481,2
    --55680556(+) CACCAC/TCACGC 3 -- int10--------
    rs1510828661,2
    --55680584(+) TTTCAG/TTAGAG 3 -- int10--------
    rs1411072151,2
    --55680592(+) GAGACA/GGGGTT 3 -- int10--------
    rs1502612701,2
    C--55680758(+) CCATCA/GATCCA 3 -- int10--------
    rs1140260781,2
    C,F--55680827(+) CAGAGT/CGAGTG 3 -- int11Minor allele frequency- C:0.03WA 118
    rs753148061,2
    C,F--55680877(+) GAGAGC/TTTCAA 3 -- int11Minor allele frequency- T:0.04NA 120
    rs1168376461,2
    C,F--55680919(+) ATGCGT/CGGAAG 3 -- int11Minor allele frequency- C:0.03WA 118
    rs1158985031,2
    F--55680921(+) GCGTGG/CAAGGT 3 -- int11Minor allele frequency- C:0.03WA 118
    rs777029421,2
    C--55680957(+) CAGGGG/ACTGGA 3 -- int12Minor allele frequency- A:0.27NA 122
    rs1388151371,2
    --55680970(+) TCTAAC/GCTCAC 3 -- int10--------
    rs124606271,2
    C,F,H--55681007(+) TGCATC/GCTGAG 3 -- int113Minor allele frequency- N:0.01EA NA WA CSA 584
    rs124629071,2
    C,F,A,H--55681018(+) GGTGAC/TTGGGA 3 -- int116Minor allele frequency- T:0.40EA NS NA WA CSA 804
    rs1419541501,2
    --55681107(+) ATCCCA/GGCACT 3 -- int10--------
    rs1844047471,2
    --55681123(+) AGGCCA/GAGACA 3 -- int10--------
    rs1457359321,2
    --55681166(+) CCTTCC/TCAAGA 3 -- int10--------
    rs1383046061,2
    --55681174(+) AGATGC/GTGAAA 3 -- int10--------
    rs345304811,2
    C--55681192(+) CTACT-/AAAAAT 3 -- int10--------
    rs746827771,2
    C--55681246(+) CTACTT/CGGGAG 3 -- int11Minor allele frequency- C:0.00CSA 1
    rs1484447061,2
    C--55681293(+) AGGTTA/TCAGTG 3 -- int10--------
    rs1397703941,2
    C--55681362(+) AAATA-/AAAAAT
            
    AAAAA
    3 -- cds10--------
    rs676876031,2
    C--55681363(+) AATAA-/AAAAAT
            
    AAAAT
    3 -- cds10--------
    rs582127821,2
    C--55681369(+) AAATA-/AAAATA
            
    GAACT
    3 -- cds10--------
    rs104215531,2
    C,A--55681370(+) AAATAA/GAACTA 3 -- int10--------
    rs72572071,2
    C,F,H--55681456(+) TGTGAA/GGGTGT 3 -- int115Minor allele frequency- G:0.40NA EA NS WA CSA 810
    rs751910521,2
    F--55681545(+) GAGCGG/CTTAGA 3 -- int11Minor allele frequency- C:0.03WA 118
    rs16711911,2
    C,F,O,A,H--55681560(+) GTGCTA/GTGTCC 3 -- int117Minor allele frequency- G:0.26EA NA NS WA CSA 852
    rs794366281,2
    --55681569(+) CCAGGC/TGCCTA 3 -- int10--------
    rs799251971,2
    F--55681612(+) TGGACA/GCAGTG 3 -- int11Minor allele frequency- G:0.03WA 118
    rs1472174891,2
    --55681633(+) TTAAAC/TACCTG 3 -- int10--------
    rs752786981,2
    C,F--55681649(+) CAGCCG/AAGTCC 3 -- int11Minor allele frequency- A:0.03WA 118
    rs16544151,2
    C,F,O,A,H--55681754(+) CAAAAT/CGCTCC 3 -- int118Minor allele frequency- C:0.23EA NA NS WA CSA 2278
    rs16711921,2
    C,F,O,A,H--55681851(+) AAGTGG/ATTAAA 3 -- int119Minor allele frequency- A:0.25NA NS EA WA CSA 908
    rs23041681,2
    C,F--55681854(+) TGATTA/GAAAGC 3 -- int16Minor allele frequency- G:0.19NA EA 2282
    rs2019171821,2
    C--55681943(+) CAGTTC/GTGAAG 6 T R mis10--------
    rs16544161,2,,4
    C,F,O,A,H--55681953(+) GACTTT/CGTTTG 6 /K /E mis1 ese344Minor allele frequency- C:0.22MN EA NA NS WA CSA EU 8735
    rs1995767081,2
    --55681975(+) GTCAGC/TTCAGC 6 E syn10--------
    rs2020782311,2
    C--55682002(+) TCTAAG/AAAAGC 3 -- int11Minor allele frequency- A:0.00EU 1321
    rs1403364141,2
    --55682059(+) TCTCCA/GTTCCC 3 -- int10--------
    rs778613631,2
    F--55682086(+) GCTCCC/GTGAAA 3 -- int11Minor allele frequency- G:0.01WA 118
    rs772177791,2
    F--55682187(+) AGATCC/TGTTCA 3 -- int11Minor allele frequency- T:0.03WA 118
    rs1441843401,2
    --55682293(+) TTTCTA/GTTCTC 3 -- int10--------
    rs1478048061,2
    --55682388(+) TCTTTC/TTTTTC 3 -- int10--------
    rs1136600661,2
    C,F--55682427(+) CATTCT/AGTTGC 3 -- int11Minor allele frequency- A:0.50NA 2
    rs1453595551,2
    C--55682547(+) CCATCA/CCGCCT 3 -- int10--------
    rs116700081,2
    C,H--55682586(+) gaggcA/Ggggtt 3 -- int10--------
    rs16544171,2
    C--55682616(+) ggtctC/Tgatct 3 -- int10--------
    rs1892842431,2
    --55682709(+) CAGCTC/GCACCA 3 -- int10--------
    rs802039141,2
    C,F--55682768(+) AATACT/GTCTTG 3 -- int12Minor allele frequency- G:0.05NA EA 240
    rs1809854801,2
    C--55682777(+) TGTCCA/GTTTGT 3 -- int10--------
    rs1853273011,2
    --55682787(+) TTTTGC/TTTTAA 3 -- int10--------
    rs762026451,2
    F--55682882(+) TCTTCG/ATGAGC 3 -- int11Minor allele frequency- A:0.02WA 118
    rs1885858691,2
    --55682902(+) GAATGA/GGCTCG 3 -- int10--------
    rs1180708191,2
    F--55682907(+) AGCTCG/TTGTTA 3 -- int11Minor allele frequency- T:0.01EA 120
    rs1142595441,2
    F--55682948(+) CTTAGG/ACCATT 3 -- int11Minor allele frequency- A:0.03WA 118
    rs588047581,2
    C--55682981(+) TTTTT-/T/TT  
            
    GAGAC
    3 -- int11NA 2
    rs1133975951,2
    F--55683005(+) GTCGTT/CCAGGC 3 -- int11Minor allele frequency- C:0.00CSA 1
    rs72501291,2
    C,F--55683009(+) tccagG/Tctgga 3 -- int11Minor allele frequency- T:0.50WA 2
    rs1456274541,2
    C--55683165(+) TTCACC/TGTGTT 3 -- int10--------
    rs1381831641,2
    --55683298(+) AGGCCA/TCCAAA 3 -- int10--------
    rs1813780781,2
    --55683377(+) TTTTAC/TGGTGG 3 -- int10--------
    rs1129697501,2
    C--55683385(+) TGGAAC/TCAGCT 3 -- int10--------
    rs736140461,2
    --55683491(+) TAAACC/TTTTTT 3 -- int11Minor allele frequency- T:0.50CSA 2
    rs1400870081,2
    C--55683491(+) TAAAC-/CTTT  
            
    TTTTT
    3 -- int10--------
    rs711817251,2
    C--55683492(-) AAAAA-/A/AA  
            
    GGTTT
    3 -- int12NA CSA 4
    rs2009082231,2
    C--55683492(+) AAACC-/TTTTTTTT 3 -- int10--------
    rs1502068681,2
    --55683532(+) AATCCA/GTGTGC 3 -- int10--------
    rs1860505301,2
    --55683549(+) TGCAGA/GTTTGT 3 -- int10--------
    rs1380582621,2
    --55683696(+) GTTCCC/TCTCCC 3 -- int10--------
    rs1495070131,2
    --55683751(+) AACATA/GCAGTG 3 -- int10--------
    rs779879981,2
    C,F--55684166(+) ACTCCC/TGTCTC 3 -- int11Minor allele frequency- T:0.50WA 2
    rs1908581561,2
    C--55684400(+) AGCACG/TTTGGG 3 -- int10--------
    rs1428612681,2
    --55684449(+) AGACCA/GGCATG 3 -- int10--------
    rs1473570491,2
    --55684457(+) ATGACC/TAACAA 3 -- int10--------
    rs1483926441,2
    --55684472(+) AAACCC/TCATCT 3 -- int10--------
    rs1840474641,2
    --55684506(+) AAAGCC/TAGGCA 3 -- int10--------
    rs1381385611,2
    C--55684650(+) ATCTC-/A/AA  
            
    AAAAA
    3 -- int10--------
    rs794984011,2
    C--55684742(+) CCAACA/TGTGTA 3 -- int10--------
    rs621219771,2
    C,F--55684783(+) AGCACT/CTGTTG 3 -- int14Minor allele frequency- C:0.38NA WA CSA 8
    rs2017241591,2
    --55684804(+) TTGTT-/GGGTTT 3 -- int10--------
    rs1119983751,2
    C--55684807(+) GTTGGG/TTTTTT 3 -- int11Minor allele frequency- T:0.50WA 2
    rs791060611,2
    C--55684837(+) AGTCTC/TGCTCT 3 -- int13Minor allele frequency- T:0.17NA WA 6
    rs621219781,2
    C--55684907(+) GTTCAT/CGCCAT 3 -- int13Minor allele frequency- C:0.17NA WA 6
    rs1399243031,2
    C--55684968(+) CGCCCA/GGCTAA 3 -- int10--------
    rs558971891,2
    C--55685048(+) TGATCC/TGCCTG 3 -- int13Minor allele frequency- T:0.17NA WA 6
    rs556760271,2
    C,F--55685097(+) CACCGC/TGCCCG 3 -- int17Minor allele frequency- T:0.22WA NA EA 250
    rs1468871691,2
    C--55685163(+) ATGTGA/GTTTTG 3 -- int10--------
    rs80999421,2
    C,A,H--55685396(+) tcactC/Gtgatg 3 -- int10--------
    rs81007731,2
    C,A,H--55685397(+) cactcC/Tgatga 3 -- int10--------
    rs2004007761,2
    --55685397(+) ACTCT-/GCGATGA 3 -- int10--------
    rs1465479351,2
    --55685413(+) TCTTTC/TGCTGA 3 -- int10--------
    rs1829241881,2
    --55685478(+) AATTGC/TTTTTG 3 -- int10--------
    rs1491374201,2
    C--55685485(+) TTTGAC/TGTTTT 3 -- int10--------
    rs1433098451,2
    C--55685493(+) TTTTGC/TCATGA 3 -- int10--------
    rs1483201051,2
    --55685514(+) CATGCC/TTGTGT 3 -- int10--------
    rs1869858791,2
    --55685746(+) AGGATG/TCCCTC 3 -- int10--------
    rs48066321,2
    C,F--55685763(+) cactcG/Ctattc 3 -- int14Minor allele frequency- C:0.50NA WA 8
    rs1919323531,2
    --55685882(+) ATCCTA/GTATCT 3 -- int10--------
    rs1829914451,2
    --55685903(+) ATCATC/TTCAGC 3 -- int10--------
    rs1876268111,2
    --55686060(+) AGAGAA/GTAAAA 3 -- int10--------
    rs1932315881,2
    --55686146(+) AGAGCA/GGACAC 3 -- int10--------
    rs1854441261,2
    --55686155(+) ACAAAC/TAAATG 3 -- int10--------
    rs1906958471,2
    --55686193(+) ATGAAC/TCAATA 3 -- int10--------
    rs1459972821,2
    C--55686241(+) ATTCAC/TTGCTA 3 -- int10--------
    rs1921743901,2
    --55686343(+) AATACC/TAAGCA 3 -- int10--------
    rs1836322881,2
    --55686389(+) CAGACG/TATATT 3 -- int10--------
    rs1387934871,2
    --55686390(+) AGACTA/CTATTA 3 -- int10--------
    rs1885393281,2
    --55686423(+) GCATGC/GTACTG 3 -- int10--------
    rs770487711,2
    C--55686432(-) TTTTCA/GTGCCA 3 -- int13Minor allele frequency- G:0.17NA 6
    rs745268601,2
    F--55686474(+) GCCTCG/AGAAAT 3 -- int11Minor allele frequency- A:0.50NA 4
    rs1429047791,2
    --55686528(+) AAAAAC/TAAGCA 3 -- int10--------
    rs81042881,2
    C,F--55686591(+) ACAGCG/Atgtgg 3 -- int13Minor allele frequency- A:0.09WA NA EA 358
    rs736140511,2
    C--55686616(+) GTGATA/GCAGTT 3 -- int13Minor allele frequency- G:0.10WA CSA 121
    rs1474195781,2
    --55686667(+) CCCCAA/GTGTTG 3 -- int10--------
    rs1119817191,2
    C,F--55686708(+) TCATAG/AGGGTG 3 -- int12Minor allele frequency- A:0.04CSA WA 120
    rs1379564421,2
    --55686744(+) TTGCAA/GTAGTA 3 -- int10--------
    rs1383555051,2
    C--55686806(+) CCCAA-/CTCTCTC 3 -- int10--------
    rs1494552921,2
    --55686826(+) GCTCCC/TGCTCC 3 -- int10--------
    rs1813285721,2
    --55686887(+) TTCCTC/GAGGCC 3 -- int10--------
    rs16711931,2
    C,F,A,H--55686987(+) ctcagG/Atattt 3 -- int112Minor allele frequency- A:0.28NA WA CSA EA 377
    rs1439711291,2
    --55687008(+) AAAATC/TGGCCT 3 -- int10--------
    rs16544181,2
    C,F,A,H--55687030(+) aaataC/Ttgctc 3 -- int112Minor allele frequency- T:0.29NA WA CSA EA 378
    rs1858149271,2
    --55687140(+) CTGGAG/TGATCC 3 -- int10--------
    rs1486326841,2
    --55687157(+) CATCAC/GATTCT 3 -- int10--------
    rs116719221,2
    C,F,A,H--55687207(+) ataccG/Aggagt 3 -- int125Minor allele frequency- A:0.30NS EA NA WA CSA 1848
    rs573622401,2
    C--55687238(+) AGGGT-/GTAGGTG 3 -- int10--------
    rs2020013411,2
    C--55687240(+) AGGGTA/GTAGGT 3 -- int10--------
    rs2004020111,2
    --55687241(+) GGGTG-/TAGGTG 3 -- int10--------
    rs556562271,2
    C,F--55687244(+) TGTAGA/GTGTGA 3 -- int15Minor allele frequency- G:0.30NA WA 10
    rs1432419331,2
    --55687253(+) GAATAC/TAAAAG 3 -- int10--------
    rs581040741,2
    C--55687254(+) ATAAA-/AGGGTA 3 -- int10--------
    rs562676771,2
    C,F--55687262(+) AGGGTC/AGCCCA 3 -- int14Minor allele frequency- A:0.25NA WA 8
    rs1441107301,2
    C--55687262(+) GGGTA-/GATGTGAA
    TATAAAGGGTC
    GCCCA
    3 -- int10--------
    rs1901066421,2
    --55687322(+) GGTGAC/TGCGAA 3 -- int10--------
    rs110843811,2
    C,F,A,H--55687330(+) gaatcC/Tacaac 3 -- int124Minor allele frequency- T:0.28NS EA NA WA CSA 2224
    rs1165406861,2
    F--55687335(+) TACAAC/ATGTGA 3 -- int11Minor allele frequency- A:0.03WA 118
    rs116681611,2
    C,F,A,H--55687336(+) acaacG/Tgtgac 3 -- int112Minor allele frequency- T:0.30NA WA CSA EA 376
    rs110843821,2
    C,F,A,H--55687352(+) GGCATG/AGAACT 3 -- int127Minor allele frequency- A:0.29NS EA NA WA 2774
    rs116681691,2
    C,F,A,H--55687400(+) TTATGC/TTGTAC 3 -- int129Minor allele frequency- T:0.29NS EA NA WA CSA 2778
    rs116720261,2
    C,F,A,H--55687433(+) ATTAGG/AGGAAA 3 -- int128Minor allele frequency- A:0.28NS EA NA WA CSA 2760
    rs1147752291,2
    C,F--55687464(+) ATTCTT/CCTGTT 3 -- int11Minor allele frequency- C:0.04WA 118
    rs736140621,2
    C,F--55687477(+) ATCATT/GGTAGA 3 -- int13Minor allele frequency- G:0.14WA CSA 121
    rs2009508221,2
    C--55687551(+) ACACAC/TATGCA 3 -- int10--------
    rs1433674171,2
    C--55687572(+) CACAC-/ACAT  
            
    ATGCA
    3 -- int10--------
    rs30565841,2
    C--55687574(-) TGCAT-/ATGTGTG 3 -- int11Minor allele frequency- AT:0.00CSA 2
    rs594855871,2
    C--55687575(+) ACACAC/TATGCA 3 -- int10--------
    rs604570331,2
    C--55687593(+) ACACAC/TATGCA 3 -- int11Minor allele frequency- T:0.50CSA 2
    rs592044881,2
    C--55687601(+) GCACG-/CACACAC 3 -- int10--------
    rs116720651,2
    H--55687604(+) cgcacA/Gcacac 3 -- int10--------
    rs595509481,2
    F--55687608(+) CACACG/ACATAT 3 -- int12Minor allele frequency- A:0.50NA 4
    rs567244471,2
    C--55687611(+) ACACAC/TATGCA 3 -- int12Minor allele frequency- T:0.25NA 4
    rs133463911,2
    A--55687622(+) cgcacA/Gcacgc 3 -- int10--------
    rs1393113131,2
    C--55687623(+) GCACA-/CACG  
            
    CACAT
    3 -- int10--------
    rs116721651,2
    C,F,A,H--55687626(+) CACACA/GCACAT 3 -- int13Minor allele frequency- G:0.20NA 10
    rs768525381,2
    F--55687631(+) GCACAC/TGCACG 3 -- int11Minor allele frequency- T:0.50NA 6
    rs116721671,2
    H--55687636(+) tgcacA/Gcacac 3 -- int10--------
    rs793406981,2
    C--55687642(+) CACACG/ACACAT 3 -- int11Minor allele frequency- A:0.50NA 2
    rs50260221,2
    C,F,A,H--55687644(+) CACACG/ACATAT 3 -- int12Minor allele frequency- A:0.50NA WA 4
    rs50260231,2
    C,F,A,H--55687647(+) ACACAC/TATGCA 3 -- int12Minor allele frequency- T:0.50NA WA 4
    rs16544191,2
    C,F,O,A,H--55687797(+) GAGACG/ACAGGG 3 -- int132Minor allele frequency- A:0.24NS EA NA WA CSA 5042
    rs1396528851,2
    --55687855(+) GTGCAA/GGCCGT 3 -- int10--------
    rs116691501,2
    C,F,H--55687888(+) TGAGAT/CGTTTG 3 -- int123Minor allele frequency- C:0.22NS EA NA WA 4780
    rs1445575381,2
    --55687902(+) AAGTGG/TAGGGG 3 -- int10--------
    rs1151311351,2
    F--55687945(+) GTTCTC/AAAAGC 3 -- int11Minor allele frequency- A:0.02WA 118
    rs1820764351,2
    --55687974(+) CATCAG/TCATCA 3 -- int10--------
    rs767950201,2
    C,F--55688063(+) CTATTC/ATTTAA 3 -- int12Minor allele frequency- A:0.09CSA WA 120
    rs1870602671,2
    --55688104(+) TTTGAA/GAACCG 3 -- int10--------
    rs1144339831,2
    F--55688108(+) AGAACC/TGCTGA 3 -- int11Minor allele frequency- T:0.03WA 118
    rs16544201,2
    C,F,A,H--55688122(+) ATGCAA/TTCAGT 3 -- int128Minor allele frequency- T:0.28NS EA NA WA CSA 2778
    rs105268191,2
    C--55688162(+) GGTTT-/GTTG  
            
    GTTGG
    3 -- int10--------
    rs670271361,2
    C--55688189(-) AAACT-/AACC  
            
    AACCA
    3 -- int12Minor allele frequency- AACC:0.25NA 4
    rs2005005111,2
    C--55688193(-) CAAACA/TAACCA 3 -- int10--------
    rs1159705721,2
    F--55688223(+) TTCAAC/TCAGCT 3 -- int11Minor allele frequency- T:0.01WA 118
    rs455456351,2
    C--55688226(+) AACCAG/CCTGGA 3 -- int15Minor allele frequency- C:0.22NA WA EA 362
    rs1922954241,2
    C--55688245(+) TATAGC/TAAGCC 3 -- int10--------
    rs1165423781,2
    F--55688306(+) TAGGAT/CTGGGG 3 -- int11Minor allele frequency- C:0.03WA 118
    rs1808587081,2
    --55688318(+) CAGCAA/TCTTAA 3 -- int10--------
    rs1161134501,2
    F--55688329(+) CATCTA/GACTAC 3 -- int11Minor allele frequency- G:0.04WA 118
    rs1854665351,2
    --55688343(+) GGACAA/CCCACC 3 -- int10--------
    rs1511138081,2
    --55688391(+) GCAAAC/TCTGTG 3 -- int10--------
    rs765668491,2
    C,F--55688442(+) GGAGAG/CAGAGA 3 -- int11Minor allele frequency- C:0.03WA 118
    rs1901762971,2
    --55688446(+) AGAGAC/GAAGGG 3 -- int10--------
    rs2004744041,2
    --55688477(+) GTGCAA/CCAGAA 3 -- int10--------
    rs16136621,2,,4
    C,F,A,H--55688511(+) TACCGA/GGGAAG 5 P S mis1 int1 ese336Minor allele frequency- G:0.17MN NS EA NA WA CSA 5052
    rs792876671,2
    C,F--55688600(+) CTGTGG/TGTCCT 3 -- int11Minor allele frequency- T:0.03NA 120
    rs16162451,2
    C,F,A,H--55688800(+) gcctgA/Gccagt 3 -- int17Minor allele frequency- G:0.29NA WA 14
    rs1827741381,2
    --55688819(+) ACCCCA/GTCTCC 3 -- int10--------
    rs1497654001,2
    C--55688867(+) CACCTC/GTAATC 3 -- int10--------
    rs1872470361,2
    --55688910(+) ACTTGA/TACCTA 3 -- int1