GP6 Gene

Aliases
for GP6 gene

Previous GC identifers: GC19M056387 GC19M055949 GC19M060201 GC19M060216 GC19M051846

Summaries
for GP6 gene

Genomic Views
for GP6 gene

RefSeq DNA sequence:

NC_000019.9  NC_018930.1  NT_011109.16  

SwitchGear Promoter luciferase reporter plasmid: GP6 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GP6

GP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M055525:  view genomic region     (about GC identifiers)

Proteins
for GP6 gene

1 PDB 3D structure from and Proteopedia for GP6:

2GI7 (3D)    

Explore the universe of human proteins at neXtProt for GP6: NX_Q9HCN6

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for GP6 (GPVI)
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	Novus Biologicals GP6 Proteins Novus Biologicals GP6 Lysate
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	Uscn Proteins for GP6

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

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	R&D Systems Antibodies for GP6 (GPVI)
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	Uscn ELISAs and CLIAs for GP6

Protein Domains /
Families
for GP6 gene

ProtoNet protein and cluster: Q9HCN6

Function
for GP6 gene

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Gp6)

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for GP6

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GP6
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GP6
		SwitchGear 3'UTR luciferase reporter plasmid: GP6 3' UTR sequence

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GP6 OriGene shRNA RFP: GP6 OriGene siRNA: GP6
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GP6 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GP6 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GP6

Pathways & Interactions
for GP6 gene

	Super-pathway	contained gene-specific pathways
1	Platelet activation, signaling and aggregation	Platelet activation, signaling and aggregation 1.00 Hemostasis 0.43
2	GPVI-mediated activation cascade	GPVI-mediated activation cascade 1.00 GPVI stimulates PI3K beta, gamma 0.42
3	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics 1.00
4	ECM-receptor interaction	ECM-receptor interaction 1.00
5	Cell surface interactions at the vascular wall	Cell surface interactions at the vascular wall 1.00

1 R&D Systems Pathway for GP6

Blood Coagulation Signaling Pathways

5/6        Reactome Pathways for GP6

	Hemostasis
	Platelet Adhesion to exposed collagen
	Platelet activation, signaling and aggregation
	Cell surface interactions at the vascular wall
	GPVI stimulates PI3K beta, gamma

1 PharmGKB Pathway for GP6

Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

1         Kegg Pathway  (Kegg details for GP6)

ECM-receptor interaction

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for GP6 gene

Transcripts
for GP6 gene

Expression
for GP6 gene

GP6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACTGCAATA

About this image

GP6 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BrainBlood Brain BarrierEndothelial Cells			Blood Brain Barrier, Endothelium
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GP6

Orthologs
for GP6 gene

Paralogs
for GP6 gene

Paralogs for GP6 gene

KIR2DL4²  LILRB4²  LILRB1²  LILRA6²  IGSF1²  LILRA5²  KIR3DL1²  OSCAR²  

NCR1²  LILRA4²  ENSG00000217792²  TARM1²  KIR3DX1²  LILRA3²  LILRB5²  KIR3DL3²  

LILRA1²  KIR2DL1²  A1BG²  LILRB2²  KIR2DL2²  LILRA2²  KIR3DL2²  KIR2DL3²  

FCAR²  LILRB3²  

18/33 SIMAP similar genes for GP6 using alignment to 2 protein entries:     GPVI_HUMAN (see all proteins) (see all similar genes):

LILRB3    LAIR1    KIR-G1    LAIR2    p58    p140

KIR-K36    KIR-G2    KIR-K9    KIR-K15    KIR-K3    KIR-K78

KIR3DL1    KIR-K65    KIR-K64    FCAR    KIR-K61    KIR3DX1

GP6 for paralogs           About GeneDecksing

Genomic Variants
for GP6 gene

10/852 NCBI SNPs in GP6 are shown (see all 852)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs730572821,2	C,F	--	51862041(+)	TGGCCC/TCTCCC	1	--	int1		1		NA	120
rs16544381,2	C	--	51875096(+)	GCTGGG/AACTAC	3	--	us2k1		2		NA WA	4
rs16544091,2	C,F,A	--	55524620(+)	TAATTG/TTTTAT	27	--	ds5001		10		EA NA WA	388
rs1170038771,2	F	--	55524699(+)	ATCCCG/ACCTCA	3	--	ds5001		1		EA	120
rs1894948991,2		--	55524736(+)	TGTGAA/GCCACT	3	--	ds5001		0	--	--	--	--
rs783203851,2	C	--	55524747(+)	GTGCC-/TAGGCT	27	--	ds5001		1		CSA	2
rs16544101,2	C,F,A,H	--	55524813(+)	TCTGTC/TTTCTG	27	--	ds5001		31		NA NS EA WA CSA	4890
rs1806750291,2		--	55524874(+)	TTCTTA/GCATTT	3	--	ds5001		0	--	--	--	--
rs104163801,2	C,F,A,H	--	55524905(+)	TTCCCG/ATTCCC	27	--	ds5001		23		NS EA WA NA CSA	2348
rs1861295291,2		--	55524953(+)	CAGCCA/GTCGTC	3	--	ds5001		0	--	--	--	--

HapMap Linkage Disequilibrium report for GP6 (55525073 - 55549632 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for GP6
     2 CNVs: 8877 3201
     7 Indels: 89327 78279 34353 78278 78277 89326 73434
Human Gene Mutation Database (HGMD): GP6

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GP6

DNA2.0 Custom Variant and Variant Library Synthesis for GP6

Disorders / Diseases
for GP6 gene

20/32 diseases for GP6

10/20 Novoseek disease relationships for GP6 gene (see all 20)    About this table

Publications
for GP6 gene

PubMed articles for GP6 gene, integrated from 9 sources (see all 288) (see top 10): (articles sorted by number of sources associating them with GP6)

Utopia: connect your pdf to the dynamic world of online information

1. Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI. (PubMed id 11027634)^{1, 2, 3, 9} Ezumi Y.... Takayama H. (2000)
2. Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily. (PubMed id 10961879)^{1, 2, 9} Jandrot-Perrus M.... Villeval J.-L. (2000)
3. Gain- and loss-of-function mutants confirm the importance of apical residues to the primary interaction of human glycoprotein VI with collagen. (PubMed id 16405521)^{1, 2, 9} O'connor M.N.... Ouwehand W.H. (2006)
4. The influence of N-linked glycosylation on the function of platelet glycoprotein VI. (PubMed id 16014566)^{1, 2, 9} Kunicki T.J.... Furihata K. (2005)
5. Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI. (PubMed id 16861347)^{1, 2, 9} Horii K.... Herr A.B. (2006)
6. Absence of collagen-induced platelet activation cause d by compound heterozygous GPVI mutations. (PubMed id 19549989)^{1, 2, 9} Dumont B....Jandrot-Perrus M. (2009)
7. A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets. (PubMed id 9295288)^{1, 2, 9} Tsuji M.... Takayama H. (1997)
8. Platelet membrane collagen receptor glycoprotein VI polymorphism is associated with coronary thrombosis and fatal myocardial infarction in middle-aged men. (PubMed id 15306180)^{1, 4, 9} Ollikainen E....Karhunen P.J. (2004)
9. [Study on T13254C polymorphism of the platelet membrane glycoprotein VI in Chinese Han population] (PubMed id 15946524)^{1, 4} Yu Z.Q....Ruan C.G. (2005)
10. [Association of matrix metalloproteinase-9 and platelet membrane glycoprotein VI polymorphisms with acute coronary syndrome] (PubMed id 16080811)^{1, 4} Qin Q....Hui R.T. (2005)
11. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
12. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
13. Analysis of the interaction of platelet collagen receptor glycoprotein VI (GPVI) with collagen. A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen. (PubMed id 12356768)^{1, 9} Miura Y....Moroi M. (2002)
14. Platelet glycoprotein VI (GPVI) for early identificat ion of acute coronary syndrome in patients with chest pain. (PubMed id 20122713)^{1, 9} Bigalke B....Gawaz M. (2010)
15. Regulation of platelet glycoprotein VI (GPVI) surface expression and of soluble GPVI in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS). (PubMed id 19190951)^{1, 9} Bigalke B....Gawaz M. (2009)
16. A novel antiplatelet antibody therapy that induces cAMP-dependent endocytosis of the GPVI/Fc receptor gamma-chain complex. (PubMed id 18382762)^{1, 9} Takayama H....Furusako S. (2008)
17. Thrombopoietin initiates demethylation-based transcription of GP6 during megakaryocyte differentiation. (PubMed id 15701720)^{1, 9} Kanaji S....Kunicki T.J. (2005)
18. Identification of residues within human glycoprotein VI involved in the binding to collagen: evidence for the existence of distinct binding sites. (PubMed id 15466473)^{1, 9} Lecut C....Jandrot-Perrus M. (2004)
19. Snake venom metalloproteinases, crotarhagin and alborhagin, induce ectodomain shedding of the platelet collagen receptor, glycoprotein VI. (PubMed id 18064326)^{1, 9} Wijeyewickrema L.C....Andrews R.K. (2007)
20. Chimeric Fc receptors identify ligand binding regions in human glycoprotein VI. (PubMed id 16876821)^{1, 9} Dumont B....Jandrot-Perrus M. (2006)
21. Relative antithrombotic effect of soluble GPVI dimer compared with anti-GPVI antibodies in mice. (PubMed id 15507524)^{1, 9} Gruner S....Nieswandt B. (2005)
22. Soluble glycoprotein VI dimer inhibits platelet adhesion and aggregation to the injured vessel wall in vivo. (PubMed id 14656994)^{1, 9} Massberg S....Gawaz M. (2004)
23. Anti-glycoprotein VI monoclonal antibodies directly aggregate platelets independently of FcgammaRIIa and induce GPVI ectodomain shedding. (PubMed id 19235048)^{1, 9} Al-Tamimi M....Gardiner E.E. (2009)
24. Platelet glycoprotein VI. (PubMed id 19065783)^{1, 9} Jung S.M. and Moroi M. (2008)
25. Glycoprotein VI agonists have distinct dependences on the lipid raft environment. (PubMed id 17096705)^{1, 9} Quinter P.G....Daniel J.L. (2007)
26. Selective blockade of glycoprotein VI clustering on collagen helices. (PubMed id 16956881)^{1, 9} O'Connor M.N....Ouwehand W.H. (2006)
27. Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinase. (PubMed id 15308568)^{1, 9} Gardiner E.E....Andrews R.K. (2004)
28. An acquired inhibitor to the GPVI platelet collagen r eceptor in a patient with lupus nephritis. (PubMed id 19583823)^{1, 9} Nurden P....Nurden A.T. (2009)
29. Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: de-ITAM-izing FcgammaRIIa. (PubMed id 17848620)^{1, 9} Gardiner E.E....Berndt M.C. (2008)
30. Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI. (PubMed id 16219796)^{1, 9} Inoue O....Watson S.P. (2006)
31. Delineation of the region in the glycoprotein VI tail required for association with the Fc receptor gamma-chain. (PubMed id 12847105)^{1, 9} Bori-Sanz T....Tulasne D. (2003)
32. Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VI. (PubMed id 12010829)^{1, 9} Andrews R.K....Berndt M.C. (2002)
33. Cloning and analysis of the thrombopoietin-induced megakaryocyte- specific glycoprotein VI promoter and its regulation by GATA-1, Fli-1, and Sp1. (PubMed id 12359731)^{1, 9} Holmes M.L.... Chong B.H. (2002)
34. Diagnostic and therapeutic potentials of platelet gly coprotein VI. (PubMed id 20414836)^{1, 9} Bigalke B....Lindemann S. (2010)
35. Structural and interaction analysis of glycoprotein VI-binding peptide selected from a phage display library. (PubMed id 19228693)^{1, 9} Kato-Takagaki K....Takahashi H. (2009)
36. Distinct spatio-temporal Ca2+ signaling elicited by i ntegrin alpha2beta1 and glycoprotein VI under flow. (PubMed id 19622836)^{1, 9} Mazzucato M....De Marco L. (2009)
37. A compound heterozygous mutation in glycoprotein VI i n a patient with a bleeding disorder. (PubMed id 19552682)^{2, 9} Hermans C....Freson K. (2009)
38. Platelet GPVI binds to collagenous structures in the core region of human atheromatous plaque and is critical for atheroprogression in vivo. (PubMed id 18431526)^{1, 9} Schulz C....Gawaz M. (2008)
39. Contribution of platelet glycoprotein VI to the thrombogenic effect of collagens in fibrous atherosclerotic lesions. (PubMed id 15939050)^{1, 9} Cosemans J.M....Heemskerk J.W. (2005)
40. Glycoprotein VI is associated with GPIb-IX-V on the membrane of resting and activated platelets. (PubMed id 15841318)^{1, 9} Arthur J.F....Berndt M.C. (2005)
41. Surface expression of collagen receptor Fc receptor-gamma/glycoprotein VI is enhanced on platelets in type 2 diabetes and mediates release of CD40 ligand and activation of endothelial cells. (PubMed id 15277394)^{1, 9} Cabeza N....Gawaz M. (2004)
42. Principal role of glycoprotein VI in alpha2beta1 and alphaIIbbeta3 activation during collagen-induced thrombus formation. (PubMed id 15231520)^{1, 9} Lecut C....Heemskerk J.W. (2004)
43. Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody. (PubMed id 14504096)^{1, 9} Smethurst P.A....Ouwehand W.H. (2004)
44. Expression of glycoprotein VI in vascular endothelial cells. (PubMed id 12850831)^{1, 9} Sun B....Kambayashi J. (2003)
45. Identification of variation in the platelet transcriptome associated with glycoprotein 6 haplotype. (PubMed id 18569861)^{1, 9} Burns P....Watkins N.A. (2008)
46. Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor gamma chain complex. (PubMed id 18419742)^{1, 9} Riba R....Naseem K.M. (2008)
47. Differential regulation of actin stress fiber assembly and proplatelet formation by alpha2beta1 integrin and GPVI in human megakaryocytes. (PubMed id 15265786)^{1, 9} Sabri S....Vainchenker W. (2004)
48. Fc Rgamma -independent signaling by the platelet coll agen receptor glycoprotein VI. (PubMed id 12594225)^{1, 9} Locke D....Kahn M.L. (2003)
49. The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors. (PubMed id 10506151)^{1, 9} Clemetson J.M....Clemetson K.J. (1999)
50. Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by pl atelet receptor GPVI. (PubMed id 20007810)^{1, 9} Brondijk T.H....Huizinga E.G. (2010)
51. Cbl-b is a novel physiologic regulator of glycoprotei n VI-dependent platelet activation. (PubMed id 20400514)^{1, 9} Daniel J.L....Sanjay A. (2010)
52. Non-genomic effects of PPARgamma ligands: inhibition of GPVI-stimulated platelet activation. (PubMed id 20040043)^{1, 9} Moraes L.A....Gibbins J.M. (2010)
53. Fibrillar type I collagens enhance platelet-dependent thrombin generation via glycoprotein VI with direct support of alpha2beta1 but not alphaIIbbeta3 integrin. (PubMed id 16113793)^{1, 9} Lecut C....Heemskerk J.W. (2005)
54. Characterization of human glycoprotein VI gene 5' regulatory and promoter regions. (PubMed id 12377757)^{1, 9} Furihata K. and Kunicki T.J. (2002)
55. Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain. (PubMed id 10825177)^{1, 9} Nieswandt B....Zirngibl H. (2000)
56. Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain. (PubMed id 9280292)^{1, 9} Gibbins J.M....Watson S.P. (1997)
57. GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk. (PubMed id 17110603)^{1, 9} Hughan S.C....Watson S.P. (2007)
58. GPIb potentiates GPVI-induced responses in human platelets. (PubMed id 15203711)^{1, 9} Baker J....Poole A.W. (2004)
59. GPIbalpha-selective activation of platelets induces p latelet signaling events comparable to GPVI activation events. (PubMed id 20367574)^{1, 9} Gardiner E.E....Berndt M.C. (2010)
60. The low-frequency isoform of platelet glycoprotein VI b attenuates ligand-mediated signal transduction but not receptor expression or ligand binding. (PubMed id 19465689)^{1, 9} Trifiro E....Kunicki T.J. (2009)
61. Lack of association between aspirin responsiveness and seven candidate gene haplotypes in patients with symptomatic vascular disease. (PubMed id 19132198)^{1, 9} Kunicki T.J....Rothwell P.M. (2009)
62. Genetics of platelet reactivity in normal, healthy in dividuals. (PubMed id 19740098)^{1, 9} Kunicki T.J....Nugent D.J. (2009)
63. Impaired activation of platelets lacking protein kinase C-theta isoform. (PubMed id 19164598)^{1, 9} Nagy B....Kunapuli S.P. (2009)
64. High loading dose of clopidogrel is unable to satisfa ctorily inhibit platelet reactivity in patients with glycoprotein IIIA gene pol ymorphism: a genetic substudy of PRAGUE-8 trial. (PubMed id 19530321)^{1, 9} Motovska Z....Kala P. (2009)
65. Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets. (PubMed id 19030108)^{1, 9} Pears C.J....Watson S.P. (2008)
66. Nitric oxide specifically inhibits integrin-mediated platelet adhesion and spreading on collagen. (PubMed id 18983487)^{1, 9} Roberts W....Naseem K.M. (2008)
67. Collagen promotes sustained glycoprotein VI signaling in platelets and cell lines. (PubMed id 17764536)^{1, 9} Tomlinson M.G....Watson S.P. (2007)
68. Platelet Reactivity and Genetics down on the Pharm. (PubMed id 18528467)^{1, 9} Bray P.F. (2006)
69. Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients. (PubMed id 16493486)^{1, 9} Lepantalo A....Lassila R. (2006)
70. Human atheromatous plaques stimulate thrombus formation by activating platelet glycoprotein VI. (PubMed id 15923400)^{1, 9} Penz S....Siess W. (2005)
71. Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen. (PubMed id 15456756)^{1, 9} Pearce A.C....Vigorito E. (2004)
72. Platelet receptor interplay regulates collagen-induced thrombus formation in flowing human blood. (PubMed id 14563646)^{1, 9} Siljander P.R....Heemskerk J.W. (2004)
73. Activation of GPVI by collagen is regulated by alpha2beta1 and secondary mediators. (PubMed id 12871331)^{1, 9} Atkinson B.T....Watson S.P. (2003)
74. Physical and functional interaction between cell-surface calreticulin and the collagen receptors integrin alpha2beta1 and glycoprotein VI in human platelets. (PubMed id 12362238)^{1, 9} Elton C.M....Farndale R.W. (2002)
75. Glycoprotein VI-mediated platelet fibrinogen receptor activation occurs through calcium-sensitive and PKC-sensitive pathways without a requirement for secreted ADP. (PubMed id 11964287)^{1, 9} Quinton T.M....Kunapuli S.P. (2002)
76. Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI. (PubMed id 11825911)^{1, 9} Barry F.A. and Gibbins J.M. (2002)
77. Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets. (PubMed id 1715582)^{1, 9} Huang M.M....Brugge J.S. (1991)
78. Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowin g blood. (PubMed id 22773837)¹ Jung S.M....Farndale R.W. (2012)
79. ITAM receptor-mediated generation of reactive oxygen s pecies in human platelets occurs via Syk-dependent and Syk-independent pathways. (PubMed id 22489915)¹ Arthur J.F....Andrews R.K. (2012)
80. Platelet aggregation abnormalities in patients with fe tal losses: the GP6 gene polymorphism. (PubMed id 22901851)¹ Sokol J....Kubisz P. (2012)
81. Platelet glycoprotein VI dimerization, an active proce ss inducing receptor competence, is an indicator of platelet reactivity. (PubMed id 22155453)¹ Loyau S....Jandrot-Perrus M. (2012)
82. Focusing on plasma glycoprotein VI. (PubMed id 22274761)¹ Al-Tamimi M....Andrews R.K. (2012)
83. Pathologic shear triggers shedding of vascular recepto rs: a novel mechanism for down-regulation of platelet glycoprotein VI in stenose d coronary vessels. (PubMed id 22431567)¹ Al-Tamimi M....Gardiner E.E. (2012)
84. A humanized glycoprotein VI (GPVI) mouse model to asse ss the antithrombotic efficacies of anti-GPVI agents. (PubMed id 22238212)¹ Mangin P.H....Jandrot-Perrus M. (2012)
85. Analysis of protein networks in resting and collagen r eceptor (GPVI)-stimulated platelet sub-proteomes. (PubMed id 22114104)¹ Wright B....Gibbins J.M. (2011)
86. Glycoprotein VI for diagnosis of acute coronary syndro me when ECG is ambiguous. (PubMed id 20071043)¹ Bigalke B....Gawaz M. (2011)
87. GPVI and GPIbI+ mediate staphylococcal superantigen-li ke protein 5 (SSL5) induced platelet activation and direct toward glycans as po tential inhibitors. (PubMed id 21552524)¹ Hu H....Peter K. (2011)
88. Soluble glycoprotein VI is raised in the plasma of pa tients with acute ischemic stroke. (PubMed id 21193745)¹ Al-Tamimi M....Andrews R.K. (2011)
89. TNF receptor-associated factor 4 (TRAF4) is a novel b inding partner of glycoprotein Ib and glycoprotein VI in human platelets. (PubMed id 20946164)¹ Arthur J.F....Berndt M.C. (2011)
90. Coagulation-induced shedding of platelet glycoprotein VI mediated by factor Xa. (PubMed id 21252089)¹ Al-Tamimi M....Andrews R.K. (2011)
91. Platelet and soluble glycoprotein VI - novel applicati ons in diagnosis and therapy. (PubMed id 21718237)¹ Bigalke B....Gawaz M. (2011)
92. Genome-wide meta-analyses identifies seven loci assoc iated with platelet aggregation in response to agonists. (PubMed id 20526338)¹ Johnson A.D....Becker L.C. (2010)
93. RGD-ligand mimetic antagonists of integrin alphaIIbbe ta3 paradoxically enhance GPVI-induced human platelet activation. (PubMed id 20002543)¹ Jones M.L....Poole A.W. (2010)
94. The minor allele of GP6 T13254C is associated with de creased platelet activation and a reduced risk of recurrent cardiovascular even ts and mortality: results from the SMILE-platelets project. (PubMed id 20723028)¹ Snoep J.D....van der Bom J.G. (2010)
95. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
96. Platelet gene polymorphisms and risk of bleeding in p atients undergoing elective coronary angiography: a genetic substudy of the PRA GUE-8 trial. (PubMed id 20691446)¹ Motovska Z....Widimsky P. (2010)
97. Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood. (PubMed id 20351310)¹ Pugh N....Farndale R.W. (2010)
98. Roles of Src-like adaptor protein 2 (SLAP-2) in GPVI- mediated platelet activation SLAP-2 and GPVI signaling. (PubMed id 20828795)¹ Sugihara S....Kimura A. (2010)
99. A novel histidine tyrosine phosphatase, TULA-2, assoc iates with Syk and negatively regulates GPVI signaling in platelets. (PubMed id 20585042)¹ Thomas D.H....Daniel J.L. (2010)
100. Platelets amplify inflammation in arthritis via colla gen-dependent microparticle production. (PubMed id 20110505)¹ Boilard E....Lee D.M. (2010)
101. Platelet glycoprotein GP VI 13254C allele is an indep endent risk factor of premature myocardial infarction. (PubMed id 19786296)¹ Motovska Z....Katina S. (2010)
102. Platelet endothelial cell adhesion molecule-1 regulat es collagen-stimulated platelet function by modulating the association of phosp hatidylinositol 3-kinase with Grb-2-associated binding protein-1 and linker for activation of T cells. (PubMed id 20723025)¹ Moraes L.A....Gibbins J.M. (2010)
103. Polymorphisms in the platelet-specific collagen recep tor GP6 are associated with risk of nonfatal myocardial infarction in Caucasian s. (PubMed id 20227257)¹ Shaffer J.R....Donahue R.P. (2010)
104. The human megakaryocytic cell line UT-7/TPO expresses functional platelet agonist signals mediated through GPVI and thromboxane rece ptor. (PubMed id 20522022)¹ Kawaguchi T....Yokota H. (2010)
105. Phenotypic approaches to gene mapping in platelet fun ction disorders - identification of new variant of P2Y12, TxA2 and GPVI recepto rs. (PubMed id 20162250)¹ Watson S....Mumford A. (2010)
106. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
107. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (2010)
108. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. (PubMed id 19336370)¹ Dagle J.M....Murray J.C. (2009)
109. Association of genetic variants with chronic kidney d isease in individuals with different lipid profiles. (PubMed id 19578796)¹ Yoshida T....Yamada Y. (2009)
110. PECAM-1 expression and activity negatively regulate m ultiple platelet signaling pathways. (PubMed id 19850043)¹ Jones C.I....Rankin A. (2009)
111. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
112. Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains. (PubMed id 18795891)¹ Protty M.B.... Tomlinson M.G. (2009)
113. Non-redundant roles of phosphoinositide 3-kinase isof orms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation. (PubMed id 19815551)¹ Gilio K....Heemskerk J.W. (2009)
114. Convulxin forms a dimer in solution and can bind eigh t copies of glycoprotein VI: implications for platelet activation. (PubMed id 19209849)¹ Horii K....Herr A.B. (2009)
115. Role of phosphoinositide 3-kinase beta in glycoprotei n VI-mediated Akt activation in platelets. (PubMed id 19700402)¹ Kim S....Kunapuli S.P. (2009)
116. A candidate gene approach to genetic prognostic factors of IgA nephropathy--a result of Polymorphism REsearch to DIstinguish genetic factors Contributing To progression of IgA Nephropathy (PREDICT-IgAN). (PubMed id 19420105)¹ Yamamoto R....Rakugi H. (2009)
117. Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach. (PubMed id 19278955)¹ TrAcgouAt D.A....Morange P.E. (2009)
118. Novel interactions in platelet biology: CLEC-2/podopl anin and laminin/GPVI. (PubMed id 19630798)¹ Ozaki Y....Inoue O. (2009)
119. G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2. (PubMed id 18955485)¹ Mori J....Watson S.P. (2008)
120. Prothrombotic genetic variants and atherosclerosis in patients with cerebral ischemia of arterial origin. (PubMed id 18848323)¹ Pruissen D.M....Algra A. (2008)
121. Mapping the platelet profile for functional genomic studies and demonstration of the effect size of the GP6 locus. (PubMed id 17663743)¹ Jones C.I....Goodall A.H. (2007)
122. More on: glycoprotein VI oligomerization: a novel concept of platelet inhibition. (PubMed id 17958751)¹ Sigalov A.B. (2007)
123. Structural basis for the platelet-collagen interaction: the smallest motif within collagen that recognizes and activates platelet Glycoprotein VI contains two glycine-proline-hydroxyproline triplets. (PubMed id 17085439)¹ Smethurst P.A....Farndale R.W. (2007)
124. Effect of genetic variations in platelet glycoproteins Ibalpha and VI on the risk for coronary heart disease events in postmenopausal women taking hormone therapy. (PubMed id 17105818)¹ Bray P.F....Herrington D.M. (2007)
125. Lipid rafts facilitate the interaction of PECAM-1 with the glycoprotein VI-FcR gamma-chain complex in human platelets. (PubMed id 17068334)¹ Lee F.A....Farndale R.W. (2006)
126. Hepatitis C virus interacts with human platelet glycoprotein VI. (PubMed id 16847120)¹ Zahn A....Allain J.P. (2006)
127. GPVI and integrin alphaIIb beta3 signaling in platelets. (PubMed id 16102042)¹ Watson S.P....Pearce A.C. (2005)
128. Rapid ubiquitination of Syk following GPVI activation in platelets. (PubMed id 15701717)¹ Dangelmaier C.A....Daniel J.L. (2005)
129. Platelet activation induces metalloproteinase-dependent GP VI cleavage to down-regulate platelet reactivity to collagen. (PubMed id 15339851)¹ Stephens G....Phillips D.R. (2005)
130. GPVI and alpha2beta1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow. (PubMed id 15886326)¹ Sarratt K.L....Kahn M.L. (2005)
131. Collagen-induced generation of platelet-derived microparticles in whole blood is dependent on ADP released from red blood cells and calcium ions. (PubMed id 15203713)¹ Takano K....Ozaki Y. (2004)
132. Multivariate QTL linkage analysis suggests a QTL for platelet count on chromosome 19q. (PubMed id 15280902)¹ Evans D.M....Martin N.G. (2004)
133. Platelet 12-lipoxygenase activation via glycoprotein VI: involvement of multiple signaling pathways in agonist control of H(P)ETE synthesis. (PubMed id 15142951)¹ Coffey M.J....O'Donnell V.B. (2004)
134. The low-frequency allele of the platelet collagen signaling receptor glycoprotein VI is associated with reduced functional responses and expression. (PubMed id 12560230)¹ Joutsi-Korhonen L....Ouwehand W.H. (2003)
135. Platelet-collagen interaction: is GPVI the central receptor? (PubMed id 12649139)¹ Nieswandt B. and Watson S.P. (2003)
136. Collagen platelet receptor polymorphisms integrin alpha2beta1 C807T and GPVI Q317L and risk of ischemic stroke. (PubMed id 12871362)¹ Cole V.J....Baker R.I. (2003)
137. Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets. (PubMed id 12049640)¹ Wonerow P....Watson S.P. (2002)
138. Differences in adhesion receptor expression between immature and older platelets and red blood cells of neonates and adults. (PubMed id 11990697)¹ Saving K.L....Gorman M.J. (2002)
139. Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling. (PubMed id 11943772)¹ Suzuki-Inoue K....Watson S.P. (2002)
140. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
141. Cloning and expression of the platelet-specific collagen receptor glycoprotein VI. (PubMed id 10822077)¹ Miura Y....Moroi M. (2000)
142. Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor. (PubMed id 9153205)¹ Polgar J....Clemetson K.J. (1997)
143. A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase C gamma2 in platelets independent of the integrin alpha2beta1. (PubMed id 9028946)¹ Asselin J....Watson S.P. (1997)
144. Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine. (PubMed id 8617742)¹ Peters J.D....Geahlen R.L. (1996)
145. A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion. (PubMed id 2808700)¹ Moroi M.... Shinmyozu K. (1989)
146. Distinct contributions of glycoprotein VI and alpha(2)beta(1) integrin to the induction of platelet protein tyrosine phosphorylation and aggregation. (PubMed id 10666318)⁹ Kamiguti A.S....Zuzel M. (2000)
147. Expression of platelet glycoprotein VI is associated with transient ischemic attack and stroke. (PubMed id 19686349)⁹ Bigalke B....Gawaz M. (2010)
148. [Advances in the studies of platelet glycoprotein VI (GPVI): review] (PubMed id 17096916)⁹ Chu X.X. and Hou M. (2006)
149. Establishment of a flow cytometric assay for determination of human platelet glycoprotein VI based on a mouse polyclonal antibody. (PubMed id 17115418)⁹ Qu C.X....Wu S.L. (2006)
150. A new monoclonal antibody, mAb 204-11, that influences the binding of platelet GPVI to fibrous collagen. (PubMed id 12783112)⁹ Moroi M....Jung S.M. (2003)
151. Measuring soluble platelet glycoprotein VI in human plasma by ELISA. (PubMed id 19437330)⁹ Al-Tamimi M....Andrews R.K. (2009)
152. Platelet collagen receptor glycoprotein VI as a possible novel indicator for the acute coronary syndrome. (PubMed id 18585516)⁹ Bigalke B....Gawaz M. (2008)
153. Intracellular localization of glycoprotein VI in human platelets and its surface expression upon activation. (PubMed id 12786802)⁹ Suzuki H....Takayama H. (2003)
154. Human platelet glycoprotein VI function is antagonized by monoclonal antibody-derived Fab fragments. (PubMed id 14675102)⁹ Lecut C....Jandrot-Perrus M. (2003)
155. Variation in human platelet glycoprotein VI content modulates glycoprotein VI-specific prothrombinase activity. (PubMed id 11701478)⁹ Furihata K....Kunicki T.J. (2001)
156. Influence of platelet count on the expression of platelet collagen receptor glycoprotein VI (GPVI) in patients with acute coronary syndrome. (PubMed id 19404545)⁹ Bigalke B....Gawaz M. (2009)
157. Presence of platelet-associated anti-glycoprotein (GP )VI autoantibodies and restoration of GPVI expression in patients with GPVI def iciency. (PubMed id 19522742)⁹ Akiyama M....Tomiyama Y. (2009)
158. Severe deficiency of glycoprotein VI in a patient with gray platelet syndrome. (PubMed id 15010364)⁹ Nurden P....Nurden A.T. (2004)
159. GPVI levels in platelets: relationship to platelet function at high shear. (PubMed id 12829582)⁹ Best D....Watson S.P. (2003)
160. A snake venom metalloproteinase, kistomin, cleaves platelet glycoprotein VI and impairs platelet functions. (PubMed id 18624975)⁹ Hsu C.C....Huang T.F. (2008)
161. Glycoprotein VI oligomerization in cell lines and platelets. (PubMed id 17367493)⁹ Berlanga O....Watson S.P. (2007)
162. [Expression of platelet collagen receptor-glycoprotei n VI fragment in E. coli and its biological activities] (PubMed id 15854297)⁹ Yu Z.Q....Ruan C.G. (2005)
163. Expression and function of the collagen receptor GPVI during megakaryocyte maturation. (PubMed id 11278467)⁹ Lagrue-Lak-Hal A.H....Vainchenker W. (2001)
164. Expression of the platelet receptor GPVI confers signaling via the Fc receptor gamma -chain in response to the snake venom convulxin but not to collagen. (PubMed id 11152687)⁹ Zheng Y.M....Kahn M.L. (2001)
165. Identification of novel downstream targets of platele t glycoprotein VI activation by differential proteome analysis: implications fo r thrombus formation. (PubMed id 20107233)⁹ Schulz C....Arnold G.J. (2010)
166. Structural basis for platelet antiaggregation by angi otensin II type 1 receptor antagonist losartan (DuP-753) via glycoprotein VI. (PubMed id 20158191)⁹ Ono K....Takahashi H. (2010)
167. Glycoprotein VI as a prognostic biomarker for cardiov ascular death in patients with symptomatic coronary artery disease. (PubMed id 20049463)⁹ Bigalke B....Gawaz M. (2010)
168. Platelet glycoprotein VI: a novel marker for acute coronary syndrome. (PubMed id 17340467)⁹ Bigalke B....Gawaz M. (2007)
169. Reciprocal signaling by integrin and nonintegrin receptors during collagen activation of platelets. (PubMed id 12832464)⁹ Chen H. and Kahn M.L. (2003)
170. Structure-activity relationships of snake toxins targeting platelet receptors, glycoprotein Ib-IX-V and glycoprotein VI. (PubMed id 15320694)⁹ Andrews R.K....Berndt M.C. (2003)
171. A familial platelet function disorder associated with abnormal signalling through the glycoprotein VI pathway. (PubMed id 17539777)⁹ Dunkley S....Andrews R.K. (2007)
172. Characterization of a patient with glycoprotein (GP) VI deficiency possessing neither anti-GPVI autoantibody nor genetic aberration. (PubMed id 17059472)⁹ Kojima H....Nagasawa T. (2006)
173. Expression of platelet collagen receptor glycoprotein VI is associated with acute coronary syndrome. (PubMed id 16923742)⁹ Bigalke B....Gawaz M. (2006)
174. Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites. (PubMed id 14656219)⁹ Suzuki-Inoue K....Watson S.P. (2004)
175. Anti-GPVI-associated ITP: an acquired platelet disorder caused by autoantibody-mediated clearance of the GPVI/FcRgamma-chain complex from the human platelet surface. (PubMed id 15150079)⁹ Boylan B....Newman P.J. (2004)
176. Convulxin binds to native, human glycoprotein Ib alpha. (PubMed id 12881531)⁹ Kanaji S....Kunicki T.J. (2003)
177. EMMPRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI-EMMPRIN interaction. (PubMed id 19350111)⁹ Seizer P....May A.E. (2009)
178. Compromised ITAM-based platelet receptor function in a patient with immune thrombocytopenic purpura. (PubMed id 18485087)⁹ Gardiner E.E....Baker R.I. (2008)
179. Activation-independent, antibody-mediated removal of GPVI from circulating human platelets: development of a novel NOD/SCID mouse model to evaluate the in vivo effectiveness of anti-human platelet agents. (PubMed id 16569773)⁹ Boylan B....Newman P.J. (2006)
180. Role of calmodulin in platelet receptor function. (PubMed id 16250859)⁹ Gardiner E.E....Andrews R.K. (2005)
181. Platelet glycoprotein VI: its structure and function. (PubMed id 15381385)⁹ Moroi M. and Jung S.M. (2004)
182. Anti GPVI human antibodies neutralizing collagen-induced platelet aggregation isolated from a combinatorial phage display library. (PubMed id 12454370)⁹ Qian M.D....Gill D. (2002)
183. Adhesion and activation of human platelets induced by convulxin involve glycoprotein VI and integrin alpha2beta1. (PubMed id 9341142)⁹ Jandrot-Perrus M....Bon C. (1997)
184. Platelets with 10% of the normal amount of glycoprotein VI have an impaired response to collagen that results in a mild bleeding tendency. (PubMed id 7530476)⁹ Arai M....Tanoue K. (1995)
185. The novel Syk inhibitor R406 reveals mechanistic diff erences in the initiation of GPVI and CLEC-2 signaling in platelets. (PubMed id 19422460)⁹ Spalton J.C....Watson S.P. (2009)
186. Platelet glycoprotein VI-related clinical defects. (PubMed id 17910626)⁹ Arthur J.F....Andrews R.K. (2007)
187. Enzymatically catalyzed disulfide exchange is required for platelet adhesion to collagen via integrin alpha2beta1. (PubMed id 12791669)⁹ Lahav J....Farndale R.W. (2003)
188. The platelet receptor GPVI mediates both adhesion and signaling responses to collagen in a receptor density-dependent fashion. (PubMed id 11723134)⁹ Chen H....Kahn M.L. (2002)
189. Lipid rafts orchestrate signaling by the platelet rec eptor glycoprotein VI. (PubMed id 11844795)⁹ Locke D....Kahn M.L. (2002)
190. Signal transduction pathways mediated by glycoprotein Ia/IIa in human platelets: comparison with those of glycoprotein VI. (PubMed id 10066433)⁹ Inoue K....Morita T. (1999)
191. Collagen-platelet interaction: Gly-Pro-Hyp is uniquel y specific for platelet Gp VI and mediates platelet activation by collagen. (PubMed id 10341844)⁹ Knight C.G....Barnes M.J. (1999)
192. The acetic acid test in evaluation of subclinical genital papillomavirus infection: a comparative study on penoscopy, histopathology, virology and scanning electron microscopy findings. (PubMed id 1316310)⁹ Wikstrom A....von Krogh G. (1992)
193. Glycoprotein (GP) VI dimer as a major collagen-bindin g site of native platelets: direct evidence obtained with dimeric GPVI-specific Fabs. (PubMed id 19486274)⁹ Jung S.M....Moroi M. (2009)
194. Novel mechanistic concept of platelet inhibition. (PubMed id 18479215)⁹ Sigalov A.B. (2008)
195. The highly specific platelet glycoprotein (GP) VI agonist trowaglerix impaired collagen-induced platelet aggregation ex vivo through matrix metalloproteinase-dependent GPVI shedding. (PubMed id 18221359)⁹ Chang C.H....Huang T.F. (2008)
196. Platelet GPIbalpha, GPIV and vWF polymorphisms and fatal pre-hospital MI among middle-aged men. (PubMed id 17619827)⁹ Pellikka M....Mikkelsson J. (2007)
197. Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor glycoprotein VI-Fc receptor gamma chain complex on human platelets. (PubMed id 9670039)⁹ Ezumi Y....Takayama H. (1998)
198. Molecular priming of Lyn by GPVI enables an immune re ceptor to adopt a hemostatic role. (PubMed id 19940238)⁹ Schmaier A.A....Kahn M.L. (2009)
199. Effect of multimer size and a natural dimorphism on the binding of convulxin to platelet glycoprotein (GP)VI. (PubMed id 16689765)⁹ Kato K....Kunicki T.J. (2006)
200. Defective collagen-induced platelet activation in two patients with malignant haemopathies is related to a defect in the GPVI-coupled signalling pathway. (PubMed id 15630503)⁹ Bellucci S....Jandrot-Perrus M. (2005)
201. Adhesive surface determines raft composition in platelets adhered under flow. (PubMed id 16241950)⁹ van Lier M....Heijnen H.F. (2005)
202. Structure of the snake-venom toxin convulxin. (PubMed id 14684891)⁹ Batuwangala T....Jones E.Y. (2004)
203. Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway. (PubMed id 12871380)⁹ Hubbard G.P....Gibbins J.M. (2003)
204. Platelet adhesion to collagen and collagen-related peptide under flow: roles of the [alpha]2[beta]1 integrin, GPVI, and Src tyrosine kinases. (PubMed id 12869350)⁹ Polanowska-Grabowska R....Gear A.R. (2003)
205. Evidence against a direct role of the integrin alpha2beta1 in collagen-induced tyrosine phosphorylation in human platelets. (PubMed id 10727949)⁹ Hers I....Watson S.P. (2000)
206. A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen. (PubMed id 9778529)⁹ Quek L.S....Watson S.P. (1998)
207. Platelet adhesion to native type I collagen fibrils. Role of GPVI in divalent cation-dependent and -independent adhesion and thromboxane A2 generation. (PubMed id 9468482)⁹ Nakamura T....Tandon N.N. (1998)
208. Collagen-stimulated activation of Syk but not c-Src is severely compromised in human platelets lacking membrane glycoprotein VI. (PubMed id 8995228)⁹ Ichinohe T....Okuma M. (1997)
209. High plasma levels of adipocytokines are associated w ith platelet activation in patients with coronary artery disease. (PubMed id 19954410)⁹ Bigalke B....Gawaz M. (2010)
210. Curcumin inhibits GPVI-mediated platelet activation b y interfering with the kinase activity of Syk and the subsequent activation of PLCgamma2. (PubMed id 20158382)⁹ Mayanglambam A....Kunapuli S.P. (2010)
211. Novel antiplatelet agents in development: prasugrel, ticagrelor, and cangrelor and beyond. (PubMed id 19262362)⁹ Shalito I....Serebruany V. (2009)
212. New antiplatelet agents. (PubMed id 19587588)⁹ Spectre G. and Varon D. (2009)
213. Proteomic analysis of integrin alphaIIbbeta3 outside- in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions. (PubMed id 19682241)⁹ Senis Y.A....GarcA-a A. (2009)
214. Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-med iated platelet-dense granule secretion. (PubMed id 19587372)⁹ Chari R....Kunapuli S.P. (2009)
215. Suboptimal activation of protease-activated receptors enhances alpha2beta1 integrin-mediated platelet adhesion to collagen. (PubMed id 19815553)⁹ Marjoram R.J....Santoro S.A. (2009)
216. Role of membrane cholesterol in platelet calcium signalling in response to VWF and collagen under stasis and flow. (PubMed id 18521510)⁹ van Lier M....Heijnen H.F. (2008)
217. Inflammation induces hemorrhage in thrombocytopenia. (PubMed id 18256319)⁹ Goerge T....Wagner D.D. (2008)
218. Redundant mechanism of platelet adhesion to laminin and collagen under flow: involvement of von Willebrand factor and glycoprotein Ib-IX-V. (PubMed id 18450753)⁹ Inoue O....Ozaki Y. (2008)
219. L-amino acid oxidase from Naja atra venom activates and binds to human platelets. (PubMed id 18180850)⁹ Li R....Clemetson K.J. (2008)
220. Platelet receptor redox regulation. (PubMed id 18231933)⁹ Arthur J.F....Berndt M.C. (2008)
221. Characterization of a patient with atypical amegakaryocytic thrombocytopenia. (PubMed id 18194481)⁹ Kanaji S....Izuhara K. (2008)
222. Primary and secondary agonists can use P2X(1) receptors as a major pathway to increase intracellular Ca(2+) in the human platelet. (PubMed id 17362227)⁹ Fung C.Y....Mahaut-Smith M.P. (2007)
223. Characterization of a novel and potent collagen antagonist, caffeic acid phenethyl ester, in human platelets: in vitro and in vivo studies. (PubMed id 17560560)⁹ Hsiao G....Sheu J.R. (2007)
224. Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases. (PubMed id 17445093)⁹ Gardiner E.E....Berndt M.C. (2007)
225. Effects of escalating doses of tirofiban on platelet aggregation and major receptor expression in diabetic patients: hitting the TARGET in the TENACITY trial? (PubMed id 16546241)⁹ Serebruany V....Angiolillo D. (2007)
226. Preferential localization of recombinant factor VIIa to platelets activated with a combination of thrombin and a glycoprotein VI receptor agonist. (PubMed id 17229056)⁹ Kjalke M....Rojkjaer R. (2007)
227. Aegyptin, a novel mosquito salivary gland protein, specifically binds to collagen and prevents its interaction with platelet glycoprotein VI, integrin alpha2beta1, and von Willebrand factor. (PubMed id 17650501)⁹ Calvo E....Francischetti I.M. (2007)
228. Platelet senescence and death. (PubMed id 17447652)⁹ Hartley P.S. (2007)
229. Involvement of the mitogen-activated protein kinase c-Jun NH2-terminal kinase 1 in thrombus formation. (PubMed id 17785464)⁹ Kauskot A....Bryckaert M. (2007)
230. Ingestion of onion soup high in quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: a pilot study. (PubMed id 16925853)⁹ Hubbard G.P....Lovegrove J.A. (2006)
231. Assessment of platelet function in horses: ultrastructure, flow cytometry, and perfusion techniques. (PubMed id 16734093)⁹ Segura D....Escolar G. (2006)
232. An association of candidate gene haplotypes and bleeding severity in von Willebrand disease type 2A, 2B, and 2M pedigrees. (PubMed id 16409463)⁹ Kunicki T.J....Federici A.B. (2006)
233. PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation. (PubMed id 16940418)⁹ Pula G....Poole A.W. (2006)
234. Efficient expression of a transgene in platelets using simian immunodeficiency virus-based vector harboring glycoprotein Ibalpha promoter: in vivo model for platelet-targeting gene therapy. (PubMed id 16723382)⁹ Ohmori T....Sakata Y. (2006)
235. Molecular defects in the ABCA1 pathway affect platelet function. (PubMed id 16855366)⁹ Schmitz G. and Schambeck C.M. (2006)
236. Novel therapeutic agents in the management of hemorrhage and thrombosis. (PubMed id 17073609)⁹ Kempton C.L....Roberts H.R. (2006)
237. A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides. (PubMed id 16912226)⁹ Lisman T....Farndale R.W. (2006)
238. Identification of human platelet glycoprotein VI-specific IgG autoantibody and its fragments. (PubMed id 16788317)⁹ Chu X....Ma D. (2006)
239. Effects of a new pathogen-reduction technology (Mirasol PRT) on functional aspects of platelet concentrates. (PubMed id 15934989)⁹ Perez-Pujol S....Escolar G. (2005)
240. Regulation of platelet guanylyl cyclase by collagen: evidence that Glycoprotein VI mediates platelet nitric oxide synthesis in response to collagen. (PubMed id 16113831)⁹ Riba R....Naseem K.M. (2005)
241. Platelet heterogeneity: variation in coagulation complexes on platelet subpopulations. (PubMed id 15653564)⁹ Kempton C.L....Monroe D.M. (2005)
242. The intracellular action of sphingosine 1-phosphate in GPVI-mediated Ca2+ mobilization in platelets. (PubMed id 15733975)⁹ Ohmori T....Ozaki Y. (2005)
243. Snake C-type lectin-like proteins and platelet receptors. (PubMed id 16707918)⁹ Clemetson K.J....Clemetson J.M. (2005)
244. Adhesion of human and mouse platelets to collagen under shear: a unifying model. (PubMed id 15758040)⁹ Auger J.M....Heemskerk J.W. (2005)
245. Functional interaction of protein kinase Calpha with the tyrosine kinases Syk and Src in human platelets. (PubMed id 15583006)⁹ Pula G....Poole A.W. (2005)
246. Rapid receptor-proximal signaling assays for FcR gamma-containing receptors. (PubMed id 16048727)⁹ Mukasa R....Takashi T. (2005)
247. Selective impairment of platelet activation to collagen in the absence of GATA1. (PubMed id 15701726)⁹ Hughan S.C....Watson S.P. (2005)
248. Genetic variation responsible for mouse strain differences in integrin alpha 2 expression is associated with altered platelet responses to collagen. (PubMed id 14739220)⁹ Li T.T....Bray P.F. (2004)
249. Monoclonal antibody IAC-1 is specific for activated a lpha2beta1 and binds to amino acids 199 to 201 of the integrin alpha2 I-domain. (PubMed id 15039278)⁹ Schoolmeester A....Deckmyn H. (2004)
250. Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced alpha2beta1 levels or concomitant aspirin therapy. (PubMed id 15505105)⁹ GrA1ner S....Nieswandt B. (2004)
251. Differential roles of integrins alpha2beta1 and alphaIIbbeta3 in collagen and CRP-induced platelet activation. (PubMed id 15370101)⁹ Jarvis G.E....Watson S.P. (2004)
252. Platelet interactions in thrombosis. (PubMed id 14992375)⁹ Andrews R.K....Berndt M.C. (2004)
253. Platelet physiology and thrombosis. (PubMed id 15507277)⁹ Andrews R.K. and Berndt M.C. (2004)
254. Blood coagulation kinetics: high throughput method for real-time reaction monitoring. (PubMed id 15467920)⁹ Lo K. and Diamond S.L. (2004)
255. Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins. (PubMed id 14645010)⁹ Garcia A....Zitzmann N. (2004)
256. Impaired platelet activation in familial high density lipoprotein deficiency (Tangier disease). (PubMed id 15163665)⁹ Nofer J.R....Kehrel B.E. (2004)
257. Interactions of 12-lipoxygenase with phospholipase A2 isoforms following platelet activation through the glycoprotein VI collagen receptor. (PubMed id 15474031)⁹ Coffey M.J....O'donnell V.B. (2004)
258. PKD: a new protein kinase C-dependent pathway in platelets. (PubMed id 12393506)⁹ Stafford M.J....Pears C.J. (2003)
259. Signaling events underlying thrombus formation. (PubMed id 12871297)⁹ Jackson S.P....Kulkarni S. (2003)
260. Identification of P2Y12-dependent and -independent mechanisms of glycoprotein VI-mediated Rap1 activation in platelets. (PubMed id 12393417)⁹ Larson M.K....Parise L.V. (2003)
261. Platelet membrane glycoprotein polymorphisms do not influence the clinical expressivity of von Willebrand disease type 1. (PubMed id 14652648)⁹ Pereira J....Mezzano D. (2003)
262. Tec regulates platelet activation by GPVI in the absence of Btk. (PubMed id 12842985)⁹ Atkinson B.T....Watson S.P. (2003)
263. Adhesion of normal erythrocytes at depressed venous shear rates to activated neutrophils, activated platelets, and fibrin polymerized from plasma. (PubMed id 12393714)⁹ Goel M.S. and Diamond S.L. (2002)
264. Glycoprotein IIb-IIIa-dependent aggregation by glycoprotein Ibalpha is reinforced by a Src family kinase inhibitor (PP1)-sensitive signalling pathway. (PubMed id 11772401)⁹ Marshall S.J....Watson S.P. (2002)
265. Platelet activation and blood coagulation. (PubMed id 12195687)⁹ Heemskerk J.W....Lindhout T. (2002)
266. Influence of platelet collagen receptor polymorphisms on risk for arterial thrombosis. (PubMed id 11860304)⁹ Furihata K....Kunicki T.J. (2002)
267. A GPVI polymorphism is a risk factor for myocardial infarction in Japanese. (PubMed id 12417295)⁹ Takagi S....Goto Y. (2002)
268. Common variations in platelet glycoproteins: pharmacogenomic implications. (PubMed id 11722284)⁹ Quinn M.J. and Topol E.J. (2001)
269. Platelet activation via the collagen receptor GPVI is not altered in platelets from chronic myeloid leukaemia patients despite the presence of the constitutively phosphorylated adapter protein CrkL. (PubMed id 11260061)⁹ Best D....Watson S.P. (2001)
270. Convulxin binding to platelet receptor GPVI: competition with collagen related peptides. (PubMed id 10873594)⁹ Niedergang F....Leduc M. (2000)
271. Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin. (PubMed id 10942756)⁹ Asazuma N.... Watson S.P. (2000)
272. Platelet function during cardiopulmonary bypass not changed by two different doses of aprotinin. (PubMed id 10756363)⁹ SantamarA-a A....Fontcuberta J. (2000)
273. Update on collagen receptor interactions in platelets: is the two-state model still valid? (PubMed id 11030459)⁹ Watson S....Frampton J. (2000)
274. LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI. (PubMed id 10567557)⁹ Pasquet J.M....Watson S.P. (1999)
275. Thrombopoietin potentiates agonist-stimulated activation of p38 mitogen-activated protein kinase in human platelets. (PubMed id 10405323)⁹ Ezumi Y....Takayama H. (1999)
276. Regulation and function of WASp in platelets by the collagen receptor, glycoprotein VI. (PubMed id 10590061)⁹ Gross B.S....Watson S.P. (1999)
277. Monomeric (glycine-proline-hydroxyproline)10 repeat sequence is a partial agonist of the platelet collagen receptor glycoprotein VI. (PubMed id 10191274)⁹ Asselin J....Watson S.P. (1999)
278. A collagen-related peptide regulates phospholipase Cgamma2 via phosphatidylinositol 3-kinase in human platelets. (PubMed id 10432314)⁹ Pasquet J.M....Watson S.P. (1999)
279. Evidence for the involvement of p59fyn and p53/56lyn in collagen receptor signalling in human platelets. (PubMed id 9931317)⁹ Briddon S.J. and Watson S.P. (1999)
280. Convulxin-induced platelet adhesion and aggregation: involvement of glycoproteins VI and IaIIa. (PubMed id 16793703)⁹ Jandrot-Perrus M....Bon C. (1998)
281. The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor gamma-chain and linker for activitor of T cells (LAT) in platelets stimulated by collagen and convulxin. (PubMed id 9852111)⁹ Gibbins J.M....Watson S.P. (1998)
282. Adhesion of activated platelets to endothelial cells: evidence for a GPIIbIIIa-dependent bridging mechanism and novel roles for endothelial intercellular adhesion molecule 1 (ICAM-1), alphavbeta3 integrin, and GPIbalpha. (PubMed id 9449713)⁹ Bombeli T....Harlan J.M. (1998)
283. Simple collagen-like peptides support platelet adhesion under static but not under flow conditions: interaction via alpha2 beta1 and von Willebrand factor with specific sequences in native collagen is a requirement to resist shear forces. (PubMed id 9573018)⁹ Verkleij M.W....Sixma J.J. (1998)
284. A novel anti-platelet monoclonal antibody induces mouse platelet aggregation through an Fc receptor-independent mechanism. (PubMed id 9446779)⁹ Kato Y....Tsuruo T. (1998)

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