Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GP6 Gene

Aliases for GP6 Gene

  • Glycoprotein VI (Platelet) 2 3
  • Glycoprotein 6 3 4
  • BDPLT11 3 6
  • GPIV 3 6
  • GPVI 3 4
  • Platelet Collagen Receptor 3
  • Platelet Glycoprotein VI 3

External Ids for GP6 Gene

Summaries for GP6 Gene

Entrez Gene Summary for GP6 Gene

  • This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for GP6 Gene

GP6 (Glycoprotein VI (Platelet)) is a Protein Coding gene. Diseases associated with GP6 include bleeding disorder, platelet-type, 11 and bleeding diathesis due to a collagen receptor defect. Among its related pathways are Hemostasis and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. GO annotations related to this gene include receptor activity and collagen binding. An important paralog of this gene is KIR2DL4.

UniProtKB/Swiss-Prot for GP6 Gene

  • Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.

Gene Wiki entry for GP6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GP6 Gene

Genomics for GP6 Gene

Genomic Location for GP6 Gene

Start:
55,013,705 bp from pter
End:
55,038,264 bp from pter
Size:
24,560 bases
Orientation:
Minus strand

Genomic View for GP6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GP6 Gene

Regulatory Elements for GP6 Gene

Proteins for GP6 Gene

  • Protein details for GP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCN6-GPVI_HUMAN
    Recommended name:
    Platelet glycoprotein VI
    Protein Accession:
    Q9HCN6
    Secondary Accessions:
    • Q9HCN7
    • Q9UIF2

    Protein attributes for GP6 Gene

    Size:
    339 amino acids
    Molecular mass:
    36866 Da
    Quaternary structure:
    • Associated with Fc receptor gamma chain. The GPVI-FcRgamma complex is associated with the Src kinase family Fyn and Lyn

    Three dimensional structures from OCA and Proteopedia for GP6 Gene

    Alternative splice isoforms for GP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GP6 Gene

Proteomics data for GP6 Gene at MOPED

Post-translational modifications for GP6 Gene

  • N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX).
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn92

Other Protein References for GP6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GP6 Gene

Domains for GP6 Gene

Gene Families for GP6 Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for GP6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GP6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCN6

UniProtKB/Swiss-Prot:

GPVI_HUMAN
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q9HCN6
genes like me logo Genes that share domains with GP6: view

Function for GP6 Gene

Molecular function for GP6 Gene

UniProtKB/Swiss-Prot Function: Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.

Gene Ontology (GO) - Molecular Function for GP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 11027634
GO:0004888 transmembrane signaling receptor activity TAS 10822077
GO:0005515 protein binding IPI 1715582
GO:0005518 collagen binding TAS 11027634
genes like me logo Genes that share ontologies with GP6: view

Phenotypes for GP6 Gene

genes like me logo Genes that share phenotypes with GP6: view

Animal Models for GP6 Gene

MGI Knock Outs for GP6:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GP6 Gene

Localization for GP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GP6 Gene

Isoform 1: Cell membrane; Single-pass membrane protein.
Isoform 2: Cell membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GP6 Gene COMPARTMENTS Subcellular localization image for GP6 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0009986 cell surface IDA 23382103
GO:0070062 extracellular exosome IDA 23376485
GO:0097197 tetraspanin-enriched microdomain IDA 18795891
genes like me logo Genes that share ontologies with GP6: view

Pathways for GP6 Gene

genes like me logo Genes that share pathways with GP6: view

Gene Ontology (GO) - Biological Process for GP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007167 enzyme linked receptor protein signaling pathway TAS 9153205
GO:0007596 blood coagulation TAS --
GO:0030168 platelet activation TAS --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with GP6: view

Compounds for GP6 Gene

(30) Novoseek inferred chemical compound relationships for GP6 Gene

Compound -log(P) Hits PubMed IDs
convulxin 97.6 65
lotrafiban 80.5 1
jararhagin 74.1 5
echicetin 71.9 1
adp 71.7 21

(1) PharmGKB related drug/compound annotations for GP6 Gene

Drug/compound Annotation
aspirin CA
genes like me logo Genes that share compounds with GP6: view

Transcripts for GP6 Gene

Unigene Clusters for GP6 Gene

Glycoprotein VI (platelet):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GP6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: -
SP2: -
SP3:

Relevant External Links for GP6 Gene

GeneLoc Exon Structure for
GP6
ECgene alternative splicing isoforms for
GP6

Expression for GP6 Gene

mRNA expression in normal human tissues for GP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GP6 Gene

This gene is overexpressed in Whole Blood (5.6) and Testis (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for GP6 Gene

SOURCE GeneReport for Unigene cluster for GP6 Gene Hs.661752

mRNA Expression by UniProt/SwissProt for GP6 Gene

Q9HCN6-GPVI_HUMAN
Tissue specificity: Megakaryocytes and platelets.
genes like me logo Genes that share expressions with GP6: view

Orthologs for GP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GP6 35
  • 95.72 (n)
  • 94.1 (a)
GP6 36
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GP6 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GP6 35
  • 79.08 (n)
  • 70.13 (a)
GP6 36
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gp6 35
  • 73.01 (n)
  • 69.55 (a)
Gp6 16
Gp6 36
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
OneToMany
-- 36
  • 29 (a)
OneToMany
-- 36
  • 19 (a)
OneToMany
-- 36
  • 24 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
-- 36
  • 23 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
-- 36
  • 30 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gp6 35
  • 71.16 (n)
  • 65.74 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 12 (a)
OneToMany
Species with no ortholog for GP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GP6 Gene

ENSEMBL:
Gene Tree for GP6 (if available)
TreeFam:
Gene Tree for GP6 (if available)

Paralogs for GP6 Gene

genes like me logo Genes that share paralogs with GP6: view

Variants for GP6 Gene

Sequence variations from dbSNP and Humsavar for GP6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs892089 -- 55,027,693(+) ATGGG(A/G)AAACT synonymous-codon, reference
rs892090 -- 55,027,704(+) AGCCC(G/T)GTACC reference, synonymous-codon
rs1613662 - 55,025,227(+) TACCG(A/G)GGAAG reference, missense, intron-variant
rs1616245 -- 55,025,516(+) gcctg(A/G)ccagt intron-variant
rs1622296 -- 55,031,483(+) AAGGG(G/T)TGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GP6 Gene

Variant ID Type Subtype PubMed ID
esv2667609 CNV Deletion 23128226
esv2718872 CNV Deletion 23290073
nsv833880 CNV Loss 17160897
esv2659880 CNV Deletion 23128226
dgv4014n71 CNV Loss 21882294
nsv912446 CNV Loss 21882294
nsv912448 CNV Loss 21882294
dgv1131e1 CNV Complex 17122850
esv34356 CNV Gain 17911159
esv2718936 CNV Deletion 23290073
esv2718937 CNV Deletion 23290073
esv2718938 CNV Deletion 23290073
nsv821557 CNV Deletion 20802225
esv25428 CNV Loss 19812545
dgv579e201 CNV Deletion 23290073
dgv580e201 CNV Deletion 23290073

Relevant External Links for GP6 Gene

HapMap Linkage Disequilibrium report
GP6
Human Gene Mutation Database (HGMD)
GP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GP6 Gene

Disorders for GP6 Gene

(1) OMIM Diseases for GP6 Gene (605546)

UniProtKB/Swiss-Prot

GPVI_HUMAN
  • Bleeding disorder, platelet-type 11 (BDPLT11) [MIM:614201]: A mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen. {ECO:0000269 PubMed:19549989, ECO:0000269 PubMed:19552682}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for GP6 Gene

(20) Novoseek inferred disease relationships for GP6 Gene

Disease -log(P) Hits PubMed IDs
thrombosis 59.1 7
arterial thrombosis 58.1 3
bleeding tendency 55.4 4
abnormal platelets 53.8 2
thrombocytopenia 35.2 3

Relevant External Links for GP6

Genetic Association Database (GAD)
GP6
Human Genome Epidemiology (HuGE) Navigator
GP6
genes like me logo Genes that share disorders with GP6: view

Publications for GP6 Gene

  1. Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI. (PMID: 11027634) Ezumi Y. … Takayama H. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23
  2. Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily. (PMID: 10961879) Jandrot-Perrus M. … Villeval J.-L. (Blood 2000) 3 4 23
  3. A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets. (PMID: 9295288) Tsuji M. … Takayama H. (J. Biol. Chem. 1997) 3 4 23
  4. Platelet membrane collagen receptor glycoprotein VI polymorphism is associated with coronary thrombosis and fatal myocardial infarction in middle-aged men. (PMID: 15306180) Ollikainen E. … Karhunen P.J. (Atherosclerosis 2004) 3 23 48
  5. The influence of N-linked glycosylation on the function of platelet glycoprotein VI. (PMID: 16014566) Kunicki T.J. … Furihata K. (Blood 2005) 3 4 23

Products for GP6 Gene

Sources for GP6 Gene

Back to Top

Content