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GP5 Gene

protein-coding   GIFtS: 60
GCID: GC03M194115

Glycoprotein V (Platelet)

  See GP5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glycoprotein V (Platelet)1 2
Glycoprotein 52 3
GPV2 3
CD42d2
Platelet Glycoprotein V2
CD42d Antigen3

External Ids:    HGNC: 44431   Entrez Gene: 28142   Ensembl: ENSG000001787327   OMIM: 1735115   UniProtKB: P401973   

Export aliases for GP5 gene to outside databases

Previous GC identifers: GC03M193330 GC03M197566 GC03M195514 GC03M195433 GC03M195595 GC03M191495


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GP5 Gene:
Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the
receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular
surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor
is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB;
MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association
of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA,
GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by
Lopez et al., 1998 (PubMed 9616133)).(supplied by OMIM, Nov 2010)

GeneCards Summary for GP5 Gene:
GP5 (glycoprotein V (platelet)) is a protein-coding gene. Diseases associated with GP5 include cervix uteri carcinoma in situ, and gray platelet syndrome. GO annotations related to this gene include collagen binding. An important paralog of this gene is CPN2.

UniProtKB/Swiss-Prot: GPV_HUMAN, P40197
Function: The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to
blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical
initiating event in hemostasis

Gene Wiki entry for GP5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the GP5 gene promoter:
         c-Fos   AP-1   HTF   ATF-2   Nkx2-5   GATA-1   FOXL1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGP5 promoter sequence
   Search Chromatin IP Primers for GP5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

GP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GP5 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M194115:  view genomic region     (about GC identifiers)

Start:
194,115,550 bp from pter      End:
194,119,995 bp from pter
Size:
4,446 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GPV_HUMAN, P40197 (See protein sequence)
Recommended Name: Platelet glycoprotein V precursor  
Size: 560 amino acids; 60959 Da

Explore the universe of human proteins at neXtProt for GP5: NX_P40197

Explore proteomics data for GP5 at MOPED

Post-translational modifications: 

  • The N-terminus is blocked1
  • Glycosylation2 at Asn51, Asn181, Asn243, Asn267, Asn298, Asn312, Asn385, Asn499
  • Modification sites at PhosphoSitePlus

  • See GP5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004479.1  
    ENSEMBL proteins: 
     ENSP00000383931   ENSP00000319286  
    Reactome Protein details: P40197

    GP5 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for GP5

     
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    antibodies-online proteins for GP5 (4 products) 

     
    antibodies-online peptides for GP5

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    antibodies-online antibodies for GP5 (12 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    4 InterPro protein domains:
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR000372 LRR-contain_N

    Graphical View of Domain Structure for InterPro Entry P40197

    ProtoNet protein and cluster: P40197

    3 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: GPV_HUMAN, P40197
    Similarity: Contains 13 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    Find genes that share domains with GP5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPV_HUMAN, P40197
    Function: The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to
    blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical
    initiating event in hemostasis

         Genatlas biochemistry entry for GP5:
    platelet glycoprotein V,83kDa,non covalently bound to the GP1B and GP9 complex in the von Willebrand receptor

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005518collagen binding IEA--
         
    Find genes that share ontologies with GP5           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gp5):
     homeostasis/metabolism  normal 

    Find genes that share phenotypes with GP5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GP5: Gp5tm1Drp Gp5tm1Cgh

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GP5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GP5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GP5

    miRNA
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    miRTarBase miRNAs that target GP5:
    hsa-let-7a-5p (MIRT052370)

    Block miRNA regulation of human, mouse, rat GP5 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate GP5:
    hsa-miR-203 hsa-miR-4251 hsa-miR-539 hsa-miR-1303 hsa-miR-186* hsa-miR-302f hsa-miR-3919 hsa-miR-708*
    SwitchGear 3'UTR luciferase reporter plasmidGP5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GP5

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: GP5 (NM_004488)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GP5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GPV_HUMAN, P40197: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7690959

    Find genes that share ontologies with GP5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GP5 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Formation of Fibrin Clot (Clotting Cascade)
    Formation of Fibrin Clot (Clotting Cascade)0.51
    Intrinsic Pathway0.00
    Blood Coagulation Signaling Pathways0.51
    2Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    3Integrin alphaIIb beta3 signaling
    Platelet Aggregation (Plug Formation)0.73
    4Focal adhesion
    ECM-receptor interaction0.31
    5Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics


    Find genes that share SuperPaths with GP5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for GP5
        Blood Coagulation Signaling Pathways


    4 Reactome Pathways for GP5
        Platelet Adhesion to exposed collagen
    Intrinsic Pathway
    GP1b-IX-V activation signalling
    Platelet Aggregation (Plug Formation)

    1 PharmGKB Pathway for GP5
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for GP5):
        ECM-receptor interaction
    Hematopoietic cell lineage

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GP5
    Interactions:

        GeneGlobe Interaction Network for GP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for GP5 (P401973 ENSP000003192864) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    F2P007343, ENSP000003085414I2D: score=1 STRING: ENSP00000308541
    YWHAZP631043, ENSP000003095034I2D: score=1 STRING: ENSP00000309503
    VWFP042753I2D: score=1 
    F12ENSP000002534964STRING: ENSP00000253496
    F8ENSP000003533934STRING: ENSP00000353393
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion NAS7690959
    GO:0007160cell-matrix adhesion IEA--
    GO:0007596blood coagulation TAS--
    GO:0007597blood coagulation, intrinsic pathway TAS--
    GO:0010544negative regulation of platelet activation IEA--

    Find genes that share ontologies with GP5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GP5 (GPV)

    4 Novoseek inferred chemical compound relationships for GP5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aspirin 31.3 1 11493449 (1)
    fibrinogen 27.2 5 12419299 (1), 18305548 (1), 18766300 (1)
    leucine 9.75 1 7900083 (1)
    lactate 0 2 16430671 (1)



    Find genes that share compounds with GP5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GP5 gene: 
    NM_004488.2  

    Unigene Cluster for GP5:

    Glycoprotein V (platelet)
    Hs.73734  [show with all ESTs]
    Unigene Representative Sequence: L11238
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000401815(uc021xiz.1) ENST00000323007(uc003ftv.1)
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate GP5:
    hsa-miR-203 hsa-miR-4251 hsa-miR-539 hsa-miR-1303 hsa-miR-186* hsa-miR-302f hsa-miR-3919 hsa-miR-708*
    SwitchGear 3'UTR luciferase reporter plasmidGP5 3' UTR sequence
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GP5
      QuantiTect SYBR Green Assays in human, mouse, rat GP5
      QuantiFast Probe-based Assays in human, mouse, rat GP5

    Additional mRNA sequence: L11238.1 

    1 DOTS entry:

    DT.95192934 

    8 AceView cDNA sequences:

    BQ287762 L11238 BM145911 BQ417219 BM145915 AA701488 NM_004488 AA342828 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTCTAAAG
    GP5 Expression
    About this image

    GP5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GP5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.73734

    UniProtKB/Swiss-Prot: GPV_HUMAN, P40197
    Tissue specificity: Platelets and megakaryocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GP5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GP5 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gp51 , 5 glycoprotein 5 (platelet)1, 5 78.73(n)1
    70.97(a)1
      16 (21.26 cM)5
    147291  NM_008148.41  NP_032174.21 
     303076935 
    chicken
    (Gallus gallus)
    Aves LOC1008575081 platelet glycoprotein V-like 52.85(n)
    45.01(a)
      100857508  XM_004943328.1  XP_004943385.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gp51 glycoprotein V (platelet) 48.22(n)
    39.56(a)
      100497902  XM_002937845.1  XP_002937891.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018844301 leucine-rich repeat-containing protein 15-like 47.63(n)
    38.76(a)
      101884430  XM_005161743.1  XP_005161800.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG169746
    --
    10(a)
    1 → many
    2L(13183849-13191979)


    ENSEMBL Gene Tree for GP5 (if available)
    TreeFam Gene Tree for GP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GP5 gene
    CPN22  LRIG32  LRRTM42  CHAD2  LRRC152  LRIG22  LRRTM32  IGFALS2  
    CHADL2  LRIG12  LRRTM22  LRRTM12  LRG12  
    1 SIMAP similar gene for GP5 using alignment to 2 protein entries:     GPV_HUMAN (see all proteins):
    LRRC15

    Find genes that share paralogs with GP5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GP5 (see all 224)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1912375321,2
    --193979578(+) AGAAGA/TTATAA 1 -- us2k10--------
    rs1830292621,2
    --193979685(+) CTGGAA/CCACAG 1 -- us2k10--------
    rs37556161,2
    C,F--193979723(+) CGCGGG/CAGGTC 1 -- us2k11Minor allele frequency- C:0.07EA 1306
    rs37556171,2
    C,F,H--193979761(+) CCAGAG/ACCCTG 1 -- us2k118Minor allele frequency- A:0.10EA NA NS WA 5686
    rs1445631321,2
    --193979770(+) TGAACG/TGCTAC 1 -- us2k10--------
    rs1875973551,2
    --193979874(+) AGACTA/GGGAAG 1 -- us2k10--------
    rs1484779881,2
    --193979893(+) TGAAAA/CAGAGT 1 -- us2k10--------
    rs713163001,2
    C,F--193980094(+) AATGAG/TAAGTA 1 -- us2k18Minor allele frequency- T:0.10NA CSA WA 250
    rs781712121,2
    C,F--193980105(+) TTTGGA/GGCAAG 1 -- us2k11Minor allele frequency- G:0.09WA 118
    rs1810781341,2
    --194115073(+) CCTCCC/TGGGTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for GP5 (194115550 - 194119995 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GP5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4178CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GP5
    DNA2.0 Custom Variant and Variant Library Synthesis for GP5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 173511    OMIM disorders: --

    3 diseases for GP5:    
    About MalaCards
    cervix uteri carcinoma in situ    gray platelet syndrome    bernard-soulier syndrome

    4 diseases from the University of Copenhagen DISEASES database for GP5:
    Cervical cancer     Carcinoma     Cervix uteri carcinoma in situ     Penis carcinoma

    Find genes that share disorders with GP5           About GenesLikeMe

    7 Novoseek inferred disease relationships for GP5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bernard-soulier syndrome 93.9 9 2372284 (2), 15550031 (1), 15477207 (1), 8407908 (1) (see all 7)
    gray platelet syndrome 79 1 8608228 (1)
    platelet disorder 67.6 2 15550031 (1), 2372284 (1)
    autoimmune thrombocytopenia 60.9 1 8888292 (1)
    coagulopathy 59.9 1 1730602 (1)
    thrombocytopenia 42.4 1 18277814 (1)
    thrombosis 38.3 5 9129030 (1), 11493449 (1), 17003930 (1), 15692116 (1)

    Genetic Association Database (GAD): GP5
    Human Genome Epidemiology (HuGE) Navigator: GP5 (5 documents)

    Export disorders for GP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GP5 gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with GP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteins. (PubMed id 7690959)1, 2, 3 Hickey M.J.... Roth G.J. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    2. Cloning and characterization of the gene encoding the human platelet glycoprotein V. A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activation. (PubMed id 8407908)1, 2, 9 Lanza F.... Phillips D.R. (J. Biol. Chem. 1993)
    3. Human platelet glycoprotein V: a surface leucine-rich glycoprotein related to adhesion. (PubMed id 2372284)1, 2, 9 Roth G.J.... Williams S.A. (Biochem. Biophys. Res. Commun. 1990)
    4. Application of a diagnostic algorithm for inherited thrombocytopenias to 46 consecutive patients. (PubMed id 15477207)1, 4, 9 Noris P....Balduini C.L. (Haematologica 2004)
    5. Rapid purification and characterization of human platelet glycoprotein V: the amino acid sequence contains leucine-rich repetitive modules as in glycoprotein Ib. (PubMed id 2350580)1, 2, 9 Shimomura T....Kuramoto A. (Blood 1990)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)1, 2 Lewandrowski U.... Sickmann A. (Mol. Cell. Proteomics 2006)
    9. Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane. (PubMed id 1730602)1, 9 Modderman P.W....von dem Borne A.E. (J. Biol. Chem. 1992)
    10. Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage. (PubMed id 9129030)1, 9 Ravanat C....Lanza F. (Blood 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2814 HGNC: 4443 AceView: GP5 Ensembl:ENSG00000178732 euGenes: HUgn2814
    ECgene: GP5 Kegg: 2814 H-InvDB: GP5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GP5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GP5 gene:
    Search GeneIP for patents involving GP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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