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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GP2 Gene

protein-coding GIFtS: 53
GCID: GC16M020320

glycoprotein 2 (zymogen granule membrane)

Explore 22 diseases affiliated with
GP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Glycoprotein 2 (Zymogen Granule Membrane)¹ ²
Pancreatic Zymogen Granule Membrane Protein GP-2² ³
ZAP75² ³
Pancreatic Secretory Granule Membrane Major Glycoprotein GP2²
Pancreatic Zymogen Granule Membrane Associated Protein GP2²

External Ids:	HGNC: 4441¹	Entrez Gene: 2813²	Ensembl: ENSG00000169347⁷	OMIM: 602977⁵	UniProtKB: P55259³

Export aliases for GP2 gene to outside databases

Previous GC identifers: GC16P019853 GC16M019752 GC16M020249 GC16M020288 GC16M020228 GC16M018858

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for GP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GP2 gene promoter:
GCNF COUP HNF-4alpha2 HNF-4alpha1 Arnt C/EBPalpha CHOP-10 AREB6 COUP-TF c-Myb
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GP2 promoter sequence

Search SABiosciences Chromatin IP Primers for GP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12 Ensembl cytogenetic band: 16p12.3 HGNC cytogenetic band: 16p12.3

GP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GP2 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M020320: view genomic region (about GC identifiers)

Start:	20,320,894 bp from pter	End:	20,339,130 bp from pter
Size:	18,237 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GP2_HUMAN, P55259 (See protein sequence)

Recommended Name: Pancreatic secretory granule membrane major glycoprotein GP2 precursor

Size: 537 amino acids; 59480 Da

Subunit: Interacts with SYCN (By similarity)

Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Secreted (By similarity). Note=Secreted

after cleavage in the pancreatic juice

Caution: It is uncertain whether Met-1 or Met-8 is the initiator

Sequence caution: Sequence=AAB19240.1; Type=Erroneous initiation;

Secondary accessions: A6NFM9 A6NJA8 Q13338 Q9UIF1

Alternative splicing: 4 isoforms: P55259-1 P55259-2 P55259-3 P55259-4

Explore the universe of human proteins at neXtProt for GP2: NX_P55259

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P55259

GP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001007241.2 NP_001007242.2 NP_001007243.2 NP_001493.2

ENSEMBL proteins:

ENSP00000304044 ENSP00000343861 ENSP00000370767 ENSP00000370765 ENSP00000460466

ENSP00000460124 ENSP00000461632 ENSP00000461061 ENSP00000460059

Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for GP2
	Uscn Proteins for GP2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0016324	apical plasma membrane	IEA	--
GO:0031225	anchored to membrane	IEA	--

GP2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for GP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GP2 for domains About GeneDecksing

2 InterPro domains/families:

IPR017977 ZP_dom_CS

IPR001507 ZP_dom

Graphical View of Domain Structure for InterPro Entry P55259

ProtoNet protein and cluster: P55259

UniProtKB/Swiss-Prot: GP2_HUMAN, P55259

Similarity: Contains 1 EGF-like domain

Similarity: Contains 1 ZP domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

Genatlas biochemistry entry for GP2:

glycoprotein 2,zymogen granule membrane of pancreatic acinar cells,homolog to uromodulin,one membrane bound and one

secreted form

miRNA Products:		OriGene 3'-UTR Clone (see all 4): GP2 Browse MicroRNA Expression Plasmids
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		hsa-miR-204 hsa-miR-589* hsa-miR-211
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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GP2 (see all 7) OriGene shRNA RFP: GP2 OriGene siRNA: GP2
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for GP2

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GP2 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GP2 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GP2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003823	antigen binding	IEA	--

GP2 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for GP2: Gp2^tm1Soka Gp2^tm1Awl
     3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Gp2):

endocrine/exocrine gland

no phenotypic analysis

normal

GP2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GP2

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5 Interacting proteins for GP2 (P55259³ ENSP00000370767⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ANXA4	P09525³, ENSP00000377833⁴	I2D: score=2 STRING: ENSP00000377833
AMY2A	P04746³	I2D: score=1
SOX30	ENSP00000265007⁴	STRING: ENSP00000265007
TSSK3	ENSP00000362634⁴	STRING: ENSP00000362634
--	ENSP00000377509⁴	STRING: ENSP00000377509

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002412	antigen transcytosis by M cells in mucosal-associated lymphoid tissue	IEA	--

GP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GP2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GP2
2 Novoseek chemical compound relationships for GP2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glycogen	18.9	3	8026640 (2), 10620373 (1)
lipid	0	2	11853552 (2)

Search CenterWatch for drugs/clinical trials and news about GP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GP2 gene (4 alternative transcripts):

NM_001007240.1 NM_001007241.1 NM_001007242.1 NM_001502.2

Unigene Cluster for GP2:

Glycoprotein 2 (zymogen granule membrane)

Hs.53985 [show with all ESTs]

Unigene Representative Sequence: CR749600

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000302555(uc002dgw.3) ENST00000341642 ENST00000381362(uc002dgv.3)

ENST00000381360(uc002dgx.3 uc002dgy.3) ENST00000573897 ENST00000575582

ENST00000574982 ENST00000572347 ENST00000572478 ENST00000575449 ENST00000575730

miRNA Products:		OriGene 3'-UTR Clone (see all 4): GP2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GP2
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate GP2:
		hsa-miR-204 hsa-miR-589* hsa-miR-211
		SwitchGear 3'UTR luciferase reporter plasmid: GP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GP2 (see all 7) OriGene shRNA RFP: GP2 OriGene siRNA: GP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GP2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GP2 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GP2 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Additional cDNA sequence:

AB035541.1 AB035542.1 AK293384.1 AK312277.1 BC032693.2 BX647831.1 BX648023.1 BX648201.1

BX649067.1 CR749600.1 D38225.1 U36221.1

23 DOTS entries:

DT.101982440 DT.97816802 DT.97804375 DT.120660863 DT.100749704 DT.100027413 DT.100655216 DT.120660937

DT.120660944 DT.120660872 DT.120660903 DT.120660940 DT.120660942 DT.97782328 DT.100655303 DT.100795902

DT.120660867 DT.120660877 DT.120660904 DT.120660950 DT.120660968 DT.100641100 DT.100655417

24/165 AceView cDNA sequences (see all 165):

BX499328 BU952392 CA941806 BQ271857 BX495079 BM310600 CA947148 AA366051

BU078090 AW873823 BX499295 CA777725 BM310899 BX498896 CA771737 BX648023

BX496089 BX498916 BM505111 BX499284 BX507147 BX499086 BG661274 BX646871

GeneLoc Exon Structure

5/24 Alternative Splicing Database (ASD) splice patterns (SP) for GP2 (see all 24) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d	·	5e	^	6a	·	6b	·	6c	·	6d	^	7	^	8a	·	8b	·	8c	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^
SP1:					-		-														-		-		-		-		-		-		-		-		-		-
SP2:																					-																		-
SP3:					-		-														-		-		-		-		-		-		-		-		-		-				-		-		-		-
SP4:					-		-														-		-		-		-		-		-		-		-		-		-										-		-
SP5:					-		-														-		-		-		-		-		-		-		-		-		-

ExUns:	15a	·	15b	·	15c	^	16a	·	16b	·	16c	·	16d	^	17	^	18a	·	18b	·	18c	·	18d	·	18e	^	19a	·	19b	·	19c	^	20a	·	20b	^	21	^	22a	·	22b	·	22c
SP1:																																	-
SP2:																																	-
SP3:
SP4:
SP5:					-		-		-

ECgene alternative splicing isoforms for GP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATTGAAGAA

About this image

GP2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Pancreas

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

See GP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GP2

SOURCE GeneReport for Unigene cluster: Hs.53985

UniProtKB/Swiss-Prot: GP2_HUMAN, P55259

Tissue specificity: Pancreatic secretory (zymogen) granule

SABiosciences Custom PCR Arrays for GP2

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for GP2 gene from 2/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	--	--	42(a)	possible ortholog	GL343621.1(80661-89493)
zebrafish (Danio rerio)	Actinopterygii	LOC100536953¹	pancreatic secretory granule membrane major glycoprotein more	55.56(n) 47.31(a)		100536953 XM_003199658.1 XP_003199706.1

ENSEMBL Gene Tree for GP2 (if available)
TreeFam Gene Tree for GP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GP2 gene

UMODL1² OIT3² UMOD²

3 SIMAP similar genes for GP2 using alignment to 7 protein entries: GP2_HUMAN (see all proteins):

DKFZp779K0533 UMOD TECTA

GP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11864405^1,2	C,F,H,	--	18858046(+)	`CTGCAT/ACTGTG`	2	--	ds500¹ ese³		9		NS EA NA WA CSA	632
rs11861170^1,2	C,F,H,	--	18858901(+)	`gagacG/Agagtt`	2	--	ut3¹ ese³		2		WA CSA	4
rs111297739^1,2	F	--	18859117(+)	`GTGCTG/AAAGGG`	2	--	ut3¹		2		CSA	4
rs7192269^1,2	C,F,	--	18860284(+)	`TAGAAG/ATGAGG`	2	--	int¹		4		WA CSA NA	242
rs75763009^1,2		--	18860572(+)	`ACTGGC/TAGAAA`	2	--	int¹		0	--	--	--	--
rs78284256^1,2	C,	--	18860971(+)	`TTTCTG/AAATGC`	2	--	int¹		3		WA NA	240
rs28395208^1,2	F,	--	18861198(+)	`TCTCTC/GTCTCT`	2	--	int¹ trp³		1		WA	118
rs78006015^1,2	F,	--	18861498(+)	`ACCTCC/TGACTC`	2	--	int¹		1		WA	118
rs78387919^1,2	F,	--	18861628(+)	`CATGGC/ACCACC`	2	--	int¹		1		WA	118
rs13336558^1,2	C,F,	--	18862224(+)	`tcttgA/Cgtttg`	2	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for GP2 (20320894 - 20339130 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GP2: --
Human Gene Mutation Database (HGMD): GP2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GP2

DNA2.0 Custom Variant and Variant Library Synthesis for GP2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GP2 for disorders           About GeneDecksing

OMIM gene information: 602977    OMIM disorders: --

20/22 diseases for GP2 (see all 22):    About MalaCards

familial juvenile hyperuricaemic nephropathy pancreatitis argentine hemorrhagic fever ebola hemorrhagic fever

lassa fever swine influenza hemorrhagic fever lymphocytic choriomeningitis

acute pancreatitis rheumatoid arthritis hepatitis c influenza

nephropathy kidney disease scleroderma arthritis

pancreatic diseases nasopharyngitis immunodeficiency hepatitis

4 diseases from the University of Copenhagen DISEASES database for GP2:

Lassa fever Vesiculitis Ebola hemorrhagic fever Lymphocytic choriomeningitis

4 Novoseek disease relationships for GP2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pancreas exocrine	68.5	3	8666297 (2), 1999417 (1)
acute pancreatitis	15.4	2	8776176 (1), 15163232 (1)
immunodeficiency	5.41	4	10838094 (1), 8642705 (1), 2229392 (1)
virus infection	0	1	8621173 (1)

Human Genome Epidemiology (HuGE) Navigator: GP2 (3 documents)

Export disorders for GP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for GP2 gene, integrated from 9 sources (see all 80):
(articles sorted by number of sources associating them with GP2)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and sequences of cDNAs encoding alpha (large) and beta (small) isoforms of human pancreatic zymogen granule membrane- associated protein GP2. (PubMed id 10760606)^{1, 2, 9} Fukuoka S. (2000)
Sequence of the cDNA encoding human GP-2, the major membrane protein in the secretory granule of the exocrine pancreas. (PubMed id 8666297)^{1, 2, 9} Wong S.M.E. and Lowe A.W. (1996)
Assignment of pancreatic zymogen granule membrane protein GP2 (GP2) to human chromosome band 9q21.11 to q21.2 by in situ hybridization. (PubMed id 9605860)^{1, 3, 9} Fukuoka S.I....Takahashi E. (1997)
Incorporation of the pancreatic membrane protein GP-2 into secretory granules in exocrine but not endocrine cells. (PubMed id 7503984)^{1, 9} Hoops T.C....Rindler M.J. (1993)
Interaction of syncollin with GP-2, the major membrane protein of pancreatic zymogen granules, and association with lipid microdomains. (PubMed id 11853552)^{1, 9} Kalus I....Schrader M. (2002)
Specific interactions of pancreatic amylase at acidic pH. Amylase and the major protein of the zymogen granule membrane (GP-2) bind to immobilized or polymerized amylase. (PubMed id 1284286)^{1, 9} Jacob M....LeBel D. (1992)
Mutational analysis of the gene encoding the zymogen granule membrane glycoprotein 2 (GP2) in patients with chronic pancreatitis. (PubMed id 19959969)^{1, 9} Witt H....Drenth J.P. (2010)
The c.1275A>G putative chronic pancreatitis-associ ated synonymous polymorphism in the glycoprotein 2 (GP2) gene decreases exon 9 inclusion. (PubMed id 19919903)^{1, 9} Boulling A....FAcrec C. (2010)
Meta-analysis identifies common variants associated wi th body mass index in east Asians. (PubMed id 22344219)¹ Wen W....Shu X.O. (2012)
Identification of pancreatic glycoprotein 2 as an endo genous immunomodulator of innate and adaptive immune responses. (PubMed id 22891285)¹ Werner L....Sturm A. (2012)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2813	HGNC: 4441	AceView: GP2	Ensembl:ENSG00000169347	euGenes: HUgn2813
ECgene: GP2	H-InvDB: GP2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GP2	Pharmacogenomics, SNPs, Pathways

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Patent Information for GP2 gene:
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