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Aliases for GP2 Gene

Aliases for GP2 Gene

  • Glycoprotein 2 2 3
  • Glycoprotein 2 (Zymogen Granule Membrane) 2 3 5
  • ZAP75 3 4
  • Pancreatic Zymogen Granule Membrane Associated Protein GP2 3
  • Pancreatic Zymogen Granule Membrane Protein GP-2 4

External Ids for GP2 Gene

Previous GeneCards Identifiers for GP2 Gene

  • GC16P019853
  • GC16M019752
  • GC16M020249
  • GC16M020288
  • GC16M020228
  • GC16M018858

Summaries for GP2 Gene

Entrez Gene Summary for GP2 Gene

  • This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for GP2 Gene

GP2 (Glycoprotein 2) is a Protein Coding gene. Diseases associated with GP2 include swine influenza and argentine hemorrhagic fever. GO annotations related to this gene include antigen binding. An important paralog of this gene is OIT3.

Gene Wiki entry for GP2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GP2 Gene

Genomics for GP2 Gene

Regulatory Elements for GP2 Gene

Enhancers for GP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GP2 Gene

Chromosome:
16
Start:
20,309,572 bp from pter
End:
20,327,820 bp from pter
Size:
18,249 bases
Orientation:
Minus strand

Genomic View for GP2 Gene

Genes around GP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GP2 Gene

Proteins for GP2 Gene

  • Protein details for GP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55259-GP2_HUMAN
    Recommended name:
    Pancreatic secretory granule membrane major glycoprotein GP2
    Protein Accession:
    P55259
    Secondary Accessions:
    • A6NFM9
    • A6NJA8
    • Q13338
    • Q9UIF1

    Protein attributes for GP2 Gene

    Size:
    537 amino acids
    Molecular mass:
    59480 Da
    Quaternary structure:
    • Interacts with SYCN.
    SequenceCaution:
    • Sequence=AAB19240.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GP2 Gene

Proteomics data for GP2 Gene at MOPED

Post-translational modifications for GP2 Gene

  • Glycosylation at Asn 65, Asn 122, Asn 134, Asn 204, Asn 216, Asn 260, Asn 291, and Asn 362
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GP2 Gene

Domains & Families for GP2 Gene

Protein Domains for GP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GP2 Gene

Graphical View of Domain Structure for InterPro Entry

P55259

UniProtKB/Swiss-Prot:

GP2_HUMAN :
  • Contains 1 EGF-like domain.
Domain:
  • Contains 1 EGF-like domain.
  • Contains 1 ZP domain.
genes like me logo Genes that share domains with GP2: view

No data available for Gene Families for GP2 Gene

Function for GP2 Gene

Molecular function for GP2 Gene

GENATLAS Biochemistry:
glycoprotein 2,zymogen granule membrane of pancreatic acinar cells,homolog to uromodulin,one membrane bound and one secreted form
genes like me logo Genes that share phenotypes with GP2: view

Animal Models for GP2 Gene

MGI Knock Outs for GP2:

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GP2 Gene

Localization for GP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GP2 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage in the pancreatic juice.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GP2 Gene COMPARTMENTS Subcellular localization image for GP2 gene
Compartment Confidence
extracellular 5
plasma membrane 4
endosome 2
golgi apparatus 2
lysosome 2
endoplasmic reticulum 1
vacuole 1

Gene Ontology (GO) - Cellular Components for GP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with GP2: view

Pathways & Interactions for GP2 Gene

SuperPathways for GP2 Gene

No Data Available

Interacting Proteins for GP2 Gene

Gene Ontology (GO) - Biological Process for GP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GP2 Gene

Drugs & Compounds for GP2 Gene

(2) Additional Compounds for GP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GP2: view

Transcripts for GP2 Gene

Unigene Clusters for GP2 Gene

Glycoprotein 2 (zymogen granule membrane):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^
SP1: - - - - - - - - - - - -
SP2: - -
SP3: - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - - -
SP14: - - - -
SP15: - - - - - - - - - - -
SP16: - - - - - - - - - - -
SP17:
SP18:
SP19: - - - - - - - - - -
SP20: - - - -
SP21: - -
SP22: -
SP23: - - - - - - - - -
SP24:

ExUns: 15a · 15b · 15c ^ 16a · 16b · 16c · 16d ^ 17 ^ 18a · 18b · 18c · 18d · 18e ^ 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c
SP1: -
SP2: -
SP3:
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10: - - - - - - - - - - - - - - - - - -
SP11: - - - -
SP12: - - -
SP13: -
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:

Relevant External Links for GP2 Gene

GeneLoc Exon Structure for
GP2
ECgene alternative splicing isoforms for
GP2

Expression for GP2 Gene

mRNA expression in normal human tissues for GP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GP2 Gene

This gene is overexpressed in Pancreas (x52.7).

Protein differential expression in normal tissues from HIPED for GP2 Gene

This gene is overexpressed in Pancreatic juice (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GP2 Gene



SOURCE GeneReport for Unigene cluster for GP2 Gene Hs.53985

mRNA Expression by UniProt/SwissProt for GP2 Gene

P55259-GP2_HUMAN
Tissue specificity: Pancreatic secretory (zymogen) granule.
genes like me logo Genes that share expression patterns with GP2: view

Protein tissue co-expression partners for GP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for GP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GP2 35
  • 83.52 (n)
  • 77.82 (a)
GP2 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GP2 35
  • 84.55 (n)
  • 78.42 (a)
GP2 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gp2 35
  • 74.12 (n)
  • 68.18 (a)
Gp2 16
Gp2 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GP2 35
  • 99.13 (n)
  • 99.06 (a)
GP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gp2 35
  • 75.51 (n)
  • 67.99 (a)
oppossum
(Monodelphis domestica)
Mammalia GP2 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GP2 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZPD 36
  • 23 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-226h7.3 36
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToMany
Species with no ortholog for GP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GP2 Gene

ENSEMBL:
Gene Tree for GP2 (if available)
TreeFam:
Gene Tree for GP2 (if available)

Paralogs for GP2 Gene

Paralogs for GP2 Gene

(3) SIMAP similar genes for GP2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with GP2: view

Variants for GP2 Gene

Sequence variations from dbSNP and Humsavar for GP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs4131902 -- 20,316,570(+) CATTA(A/G)AAAAT intron-variant
rs4383153 -- 20,327,300(-) TCAGT(C/T)ATGCT intron-variant
rs4383154 -- 20,327,288(-) CCAGT(C/T)ATCTG intron-variant
rs4393582 -- 20,323,610(-) TTTCC(C/T)AGTTT intron-variant
rs4411505 -- 20,323,357(-) CCCCA(A/G)TTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GP2 Gene

Variant ID Type Subtype PubMed ID
nsv436835 CNV Insertion 17901297

Variation tolerance for GP2 Gene

Residual Variation Intolerance Score: 50.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GP2 Gene

HapMap Linkage Disequilibrium report
GP2
Human Gene Mutation Database (HGMD)
GP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GP2 Gene

Disorders for GP2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for GP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
swine influenza
  • influenza due to influenza a virus subtype h1n1
argentine hemorrhagic fever
  • argentinian hemorrhagic fever
familial juvenile hyperuricaemic nephropathy
  • familial juvenile hyperuricemic nephropathy
lassa fever
  • lf
alcohol-related birth defect
  • fetal alcohol syndrome
- elite association - COSMIC cancer census association via MalaCards
Search GP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GP2

Genetic Association Database (GAD)
GP2
Human Genome Epidemiology (HuGE) Navigator
GP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GP2
genes like me logo Genes that share disorders with GP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GP2 Gene

Publications for GP2 Gene

  1. Mutational analysis of the gene encoding the zymogen granule membrane glycoprotein 2 (GP2) in patients with chronic pancreatitis. (PMID: 19959969) Witt H. … Drenth J.P. (Pancreas 2010) 3 23 48 67
  2. Assignment of pancreatic zymogen granule membrane protein GP2 (GP2) to human chromosome band 9q21.11 to q21.2 by in situ hybridization. (PMID: 9605860) Fukuoka S.I. … Takahashi E. (Cytogenet. Cell Genet. 1997) 2 3 23
  3. The c.1275A>G putative chronic pancreatitis-associated synonymous polymorphism in the glycoprotein 2 (GP2) gene decreases exon 9 inclusion. (PMID: 19919903) Boulling A. … FAcrec C. (Mol. Genet. Metab. 2010) 3 23
  4. Interaction of syncollin with GP-2, the major membrane protein of pancreatic zymogen granules, and association with lipid microdomains. (PMID: 11853552) Kalus I. … Schrader M. (Biochem. J. 2002) 3 23
  5. Molecular cloning and sequences of cDNAs encoding alpha (large) and beta (small) isoforms of human pancreatic zymogen granule membrane- associated protein GP2. (PMID: 10760606) Fukuoka S. (Biochim. Biophys. Acta 2000) 3 23

Products for GP2 Gene

Sources for GP2 Gene

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