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Aliases for GP2 Gene

Aliases for GP2 Gene

  • Glycoprotein 2 (Zymogen Granule Membrane) 2 3
  • ZAP75 3 4
  • Pancreatic Secretory Granule Membrane Major Glycoprotein GP2 3
  • Pancreatic Zymogen Granule Membrane Associated Protein GP2 3
  • Pancreatic Zymogen Granule Membrane Protein GP-2 4

External Ids for GP2 Gene

Summaries for GP2 Gene

Entrez Gene Summary for GP2 Gene

  • This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for GP2 Gene

GP2 (Glycoprotein 2 (Zymogen Granule Membrane)) is a Protein Coding gene. Diseases associated with GP2 include vesiculitis and ebola hemorrhagic fever. GO annotations related to this gene include antigen binding. An important paralog of this gene is OIT3.

Gene Wiki entry for GP2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GP2 Gene

Genomics for GP2 Gene

Genomic Location for GP2 Gene

Start:
20,309,572 bp from pter
End:
20,328,362 bp from pter
Size:
18,791 bases
Orientation:
Minus strand

Genomic View for GP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GP2 Gene

Regulatory Elements for GP2 Gene

Proteins for GP2 Gene

  • Protein details for GP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55259-GP2_HUMAN
    Recommended name:
    Pancreatic secretory granule membrane major glycoprotein GP2
    Protein Accession:
    P55259
    Secondary Accessions:
    • A6NFM9
    • A6NJA8
    • Q13338
    • Q9UIF1

    Protein attributes for GP2 Gene

    Size:
    537 amino acids
    Molecular mass:
    59480 Da
    Quaternary structure:
    • Interacts with SYCN.
    SequenceCaution:
    • Sequence=AAB19240.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GP2 Gene

Proteomics data for GP2 Gene at MOPED

Post-translational modifications for GP2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn65, Asn122, Asn134, Asn204, Asn216, Asn260, Asn291, and Asn362

No data available for DME Specific Peptides for GP2 Gene

Domains for GP2 Gene

Protein Domains for GP2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

GP2_HUMAN
Domain:
  • Contains 1 EGF-like domain.:
    • P55259
  • Contains 1 ZP domain.:
    • P55259
genes like me logo Genes that share domains with GP2: view

No data available for Gene Families for GP2 Gene

Function for GP2 Gene

Molecular function for GP2 Gene

GENATLAS Biochemistry: glycoprotein 2,zymogen granule membrane of pancreatic acinar cells,homolog to uromodulin,one membrane bound and one secreted form

Gene Ontology (GO) - Molecular Function for GP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
genes like me logo Genes that share ontologies with GP2: view
genes like me logo Genes that share phenotypes with GP2: view

Animal Models for GP2 Gene

MGI Knock Outs for GP2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GP2 Gene

Localization for GP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GP2 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage in the pancreatic juice.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GP2 Gene COMPARTMENTS Subcellular localization image for GP2 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 2
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for GP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016324 apical plasma membrane IEA --
GO:0031225 anchored component of membrane IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with GP2: view

Pathways for GP2 Gene

SuperPathways for GP2 Gene

No Data Available

Interacting Proteins for GP2 Gene

Gene Ontology (GO) - Biological Process for GP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002412 antigen transcytosis by M cells in mucosal-associated lymphoid tissue IEA --
genes like me logo Genes that share ontologies with GP2: view

No data available for Pathways by source for GP2 Gene

Compounds for GP2 Gene

(2) Novoseek inferred chemical compound relationships for GP2 Gene

Compound -log(P) Hits PubMed IDs
glycogen 18.9 3
lipid 0 2
genes like me logo Genes that share compounds with GP2: view

Transcripts for GP2 Gene

Unigene Clusters for GP2 Gene

Glycoprotein 2 (zymogen granule membrane):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^
SP1: - - - - - - - - - - - -
SP2: - -
SP3: - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - - -
SP14: - - - -
SP15: - - - - - - - - - - -
SP16: - - - - - - - - - - -
SP17:
SP18:
SP19: - - - - - - - - - -
SP20: - - - -
SP21: - -
SP22: -
SP23: - - - - - - - - -
SP24:

ExUns: 15a · 15b · 15c ^ 16a · 16b · 16c · 16d ^ 17 ^ 18a · 18b · 18c · 18d · 18e ^ 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c
SP1: -
SP2: -
SP3:
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10: - - - - - - - - - - - - - - - - - -
SP11: - - - -
SP12: - - -
SP13: -
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:

Relevant External Links for GP2 Gene

GeneLoc Exon Structure for
GP2
ECgene alternative splicing isoforms for
GP2

Expression for GP2 Gene

mRNA expression in normal human tissues for GP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GP2 Gene

This gene is overexpressed in Pancreas (52.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GP2 Gene

SOURCE GeneReport for Unigene cluster for GP2 Gene Hs.53985

mRNA Expression by UniProt/SwissProt for GP2 Gene

P55259-GP2_HUMAN
Tissue specificity: Pancreatic secretory (zymogen) granule
genes like me logo Genes that share expressions with GP2: view

Orthologs for GP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GP2 36
  • 99.13 (n)
  • 99.06 (a)
GP2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GP2 36
  • 83.52 (n)
  • 77.82 (a)
GP2 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GP2 36
  • 84.55 (n)
  • 78.42 (a)
GP2 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gp2 36
  • 74.12 (n)
  • 68.18 (a)
Gp2 16
Gp2 37
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GP2 37
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GP2 37
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gp2 36
  • 75.51 (n)
  • 67.99 (a)
chicken
(Gallus gallus)
Aves ZPD 37
  • 23 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 40 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-226h7.3 37
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 21 (a)
OneToMany
Species with no ortholog for GP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GP2 Gene

ENSEMBL:
Gene Tree for GP2 (if available)
TreeFam:
Gene Tree for GP2 (if available)

Paralogs for GP2 Gene

Paralogs for GP2 Gene

Selected SIMAP similar genes for GP2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with GP2: view

Variants for GP2 Gene

Sequence variations from dbSNP and Humsavar for GP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1129818 -- 20,317,363(-) AATCA(A/G)CGTGA reference, synonymous-codon, nc-transcript-variant
rs4131902 -- 20,316,570(+) CATTA(A/G)AAAAT intron-variant
rs4383153 -- 20,327,300(-) TCAGT(C/T)ATGCT intron-variant
rs4383154 -- 20,327,288(-) CCAGT(C/T)ATCTG intron-variant
rs4393582 -- 20,323,610(-) TTTCC(C/T)AGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GP2 Gene

Variant ID Type Subtype PubMed ID
nsv436835 CNV Insertion 17901297

Relevant External Links for GP2 Gene

HapMap Linkage Disequilibrium report
GP2
Human Gene Mutation Database (HGMD)
GP2

Disorders for GP2 Gene

(4) University of Copenhagen DISEASES for GP2 Gene

(4) Novoseek inferred disease relationships for GP2 Gene

Disease -log(P) Hits PubMed IDs
pancreas exocrine 68.5 3
acute pancreatitis 15.4 2
immunodeficiency 5.41 3
virus infection 0 1

Relevant External Links for GP2

Genetic Association Database (GAD)
GP2
Human Genome Epidemiology (HuGE) Navigator
GP2
genes like me logo Genes that share disorders with GP2: view

No data available for UniProtKB/Swiss-Prot for GP2 Gene

Publications for GP2 Gene

  1. Sequence of the cDNA encoding human GP-2, the major membrane protein in the secretory granule of the exocrine pancreas. (PMID: 8666297) Wong S.M.E. … Lowe A.W. (Gene 1996) 3 4 23
  2. Assignment of pancreatic zymogen granule membrane protein GP2 (GP2) to human chromosome band 9q21.11 to q21.2 by in situ hybridization. (PMID: 9605860) Fukuoka S.I. … Takahashi E. (Cytogenet. Cell Genet. 1997) 2 3 23
  3. Mutational analysis of the gene encoding the zymogen granule membrane glycoprotein 2 (GP2) in patients with chronic pancreatitis. (PMID: 19959969) Witt H. … Drenth J.P. (Pancreas 2010) 3 23 49
  4. Molecular cloning and sequences of cDNAs encoding alpha (large) and beta (small) isoforms of human pancreatic zymogen granule membrane- associated protein GP2. (PMID: 10760606) Fukuoka S. (Biochim. Biophys. Acta 2000) 3 4 23
  5. The c.1275A>G putative chronic pancreatitis-associated synonymous polymorphism in the glycoprotein 2 (GP2) gene decreases exon 9 inclusion. (PMID: 19919903) Boulling A. … FAcrec C. (Mol. Genet. Metab. 2010) 3 23

Products for GP2 Gene

Sources for GP2 Gene

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