Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GP2 Gene

Aliases for GP2 Gene

  • Glycoprotein 2 2 3 5
  • Glycoprotein 2 (Zymogen Granule Membrane) 2 3
  • ZAP75 3 4
  • Pancreatic Secretory Granule Membrane Major Glycoprotein GP2 3
  • Pancreatic Zymogen Granule Membrane Associated Protein GP2 3
  • Pancreatic Zymogen Granule Membrane Protein GP-2 4

External Ids for GP2 Gene

Previous GeneCards Identifiers for GP2 Gene

  • GC16P019853
  • GC16M019752
  • GC16M020249
  • GC16M020288
  • GC16M020228
  • GC16M018858

Summaries for GP2 Gene

Entrez Gene Summary for GP2 Gene

  • This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for GP2 Gene

GP2 (Glycoprotein 2) is a Protein Coding gene. Diseases associated with GP2 include Swine Influenza and Familial Juvenile Hyperuricaemic Nephropathy. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. Gene Ontology (GO) annotations related to this gene include antigen binding. An important paralog of this gene is UMOD.

Gene Wiki entry for GP2 Gene

Additional gene information for GP2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GP2 Gene

Genomics for GP2 Gene

GeneHancer (GH) Regulatory Elements for GP2 Gene

Promoters and enhancers for GP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I020327 Promoter/Enhancer 1.2 EPDnew ENCODE 550.8 +0.0 12 0.2 ELF3 SOX13 GATAD2A TFE3 FOXA2 TEAD1 MLX FOXA3 ZNF644 GABPA GP2 GC16P020256
GH16I020328 Promoter 0.6 EPDnew 550.8 +0.3 293 0.1 SOX13 GP2 GC16P020256
GH16I020325 Enhancer 0.2 ENCODE 550.8 +1.4 1400 1.6 GP2 GC16P020256
GH16I020350 Promoter 0.6 EPDnew 0.3 -23.0 -22998 0.1 HLF UMOD GP2
GH16I020348 Enhancer 0.5 ENCODE 0.3 -20.8 -20754 0.3 CTCF MAX ZNF143 RAD21 EZH2 UMOD GP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GP2 gene promoter:

Genomic Locations for GP2 Gene

Genomic Locations for GP2 Gene
chr16:20,309,572-20,327,820
(GRCh38/hg38)
Size:
18,249 bases
Orientation:
Minus strand
chr16:20,320,894-20,339,130
(GRCh37/hg19)

Genomic View for GP2 Gene

Genes around GP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GP2 Gene

Proteins for GP2 Gene

  • Protein details for GP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55259-GP2_HUMAN
    Recommended name:
    Pancreatic secretory granule membrane major glycoprotein GP2
    Protein Accession:
    P55259
    Secondary Accessions:
    • A6NFM9
    • A6NJA8
    • Q13338
    • Q9UIF1

    Protein attributes for GP2 Gene

    Size:
    537 amino acids
    Molecular mass:
    59480 Da
    Quaternary structure:
    • Interacts with SYCN.
    SequenceCaution:
    • Sequence=AAB19240.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GP2 Gene

Post-translational modifications for GP2 Gene

  • Glycosylation at posLast=6565, isoforms=3122, isoforms=3134, posLast=204204, posLast=216216, posLast=260260, isoforms=4, 3, 2291, and posLast=362362

No data available for DME Specific Peptides for GP2 Gene

Domains & Families for GP2 Gene

Gene Families for GP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for GP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GP2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GP2: view

No data available for UniProtKB/Swiss-Prot for GP2 Gene

Function for GP2 Gene

Molecular function for GP2 Gene

GENATLAS Biochemistry:
glycoprotein 2,zymogen granule membrane of pancreatic acinar cells,homolog to uromodulin,one membrane bound and one secreted form

Phenotypes From GWAS Catalog for GP2 Gene

genes like me logo Genes that share phenotypes with GP2: view

Animal Models for GP2 Gene

MGI Knock Outs for GP2:

miRNA for GP2 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GP2 Gene

Localization for GP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GP2 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage in the pancreatic juice.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GP2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 2
golgi apparatus 2
endosome 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
GO:0070062 extracellular exosome IDA,HDA 23533145
genes like me logo Genes that share ontologies with GP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GP2 Gene

Pathways & Interactions for GP2 Gene

genes like me logo Genes that share pathways with GP2: view

Interacting Proteins for GP2 Gene

Gene Ontology (GO) - Biological Process for GP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
genes like me logo Genes that share ontologies with GP2: view

No data available for SIGNOR curated interactions for GP2 Gene

Drugs & Compounds for GP2 Gene

(2) Additional Compounds for GP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GP2: view

Transcripts for GP2 Gene

Unigene Clusters for GP2 Gene

Glycoprotein 2 (zymogen granule membrane):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^
SP1: - - - - - - - - - - - -
SP2: - -
SP3: - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - - -
SP14: - - - -
SP15: - - - - - - - - - - -
SP16: - - - - - - - - - - -
SP17:
SP18:
SP19: - - - - - - - - - -
SP20: - - - -
SP21: - -
SP22: -
SP23: - - - - - - - - -
SP24:

ExUns: 15a · 15b · 15c ^ 16a · 16b · 16c · 16d ^ 17 ^ 18a · 18b · 18c · 18d · 18e ^ 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c
SP1: -
SP2: -
SP3:
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10: - - - - - - - - - - - - - - - - - -
SP11: - - - -
SP12: - - -
SP13: -
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:

Relevant External Links for GP2 Gene

GeneLoc Exon Structure for
GP2
ECgene alternative splicing isoforms for
GP2

Expression for GP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GP2 Gene

This gene is overexpressed in Pancreas (x52.7).

Protein differential expression in normal tissues from HIPED for GP2 Gene

This gene is overexpressed in Pancreatic juice (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GP2 Gene



Protein tissue co-expression partners for GP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GP2 Gene:

GP2

SOURCE GeneReport for Unigene cluster for GP2 Gene:

Hs.53985

mRNA Expression by UniProt/SwissProt for GP2 Gene:

P55259-GP2_HUMAN
Tissue specificity: Pancreatic secretory (zymogen) granule.

Evidence on tissue expression from TISSUES for GP2 Gene

  • Pancreas(5)
  • Liver(2.9)
  • Intestine(2.4)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with GP2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GP2 Gene

Orthologs for GP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GP2 34 33
  • 99.13 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GP2 33 34
  • 84.55 (n)
cow
(Bos Taurus)
Mammalia GP2 33 34
  • 83.52 (n)
rat
(Rattus norvegicus)
Mammalia Gp2 33
  • 75.51 (n)
mouse
(Mus musculus)
Mammalia Gp2 34 16 33
  • 74.12 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GP2 34
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GP2 34
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZPD 34
  • 23 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 40 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-226h7.3 34
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 21 (a)
OneToMany
Species where no ortholog for GP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GP2 Gene

ENSEMBL:
Gene Tree for GP2 (if available)
TreeFam:
Gene Tree for GP2 (if available)

Paralogs for GP2 Gene

Paralogs for GP2 Gene

(3) SIMAP similar genes for GP2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with GP2: view

Variants for GP2 Gene

Sequence variations from dbSNP and Humsavar for GP2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000036330 -- 20,322,471(-) C/T intron_variant
rs1000052957 -- 20,328,638(-) C/T upstream_transcript_variant
rs1000295620 -- 20,326,958(-) T/A intron_variant
rs1000395598 -- 20,327,165(-) G/A intron_variant
rs1000896870 -- 20,316,336(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GP2 Gene

Variant ID Type Subtype PubMed ID
dgv2795n100 CNV gain 25217958
nsv436835 CNV insertion 17901297

Variation tolerance for GP2 Gene

Residual Variation Intolerance Score: 50.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GP2 Gene

Human Gene Mutation Database (HGMD)
GP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GP2 Gene

Disorders for GP2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for GP2 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
swine influenza
  • influenza due to influenza a virus subtype h1n1
familial juvenile hyperuricaemic nephropathy
  • fjhn
lassa fever
  • lf
ebola hemorrhagic fever
  • ebola virus disease
foodborne botulism
  • botulism
- elite association - COSMIC cancer census association via MalaCards
Search GP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GP2 Gene

Publications for GP2 Gene

  1. Mutational analysis of the gene encoding the zymogen granule membrane glycoprotein 2 (GP2) in patients with chronic pancreatitis. (PMID: 19959969) Witt H … Drenth JP (Pancreas 2010) 3 22 44 58
  2. Molecular cloning and sequences of cDNAs encoding alpha (large) and beta (small) isoforms of human pancreatic zymogen granule membrane-associated protein GP2. (PMID: 10760606) Fukuoka S (Biochimica et biophysica acta 2000) 3 4 22 58
  3. Assignment of pancreatic zymogen granule membrane protein GP2 (GP2) to human chromosome band 9q21.11 to q21.2 by in situ hybridization. (PMID: 9605860) Fukuoka SI … Takahashi E (Cytogenetics and cell genetics 1997) 2 3 22 58
  4. Sequence of the cDNA encoding human GP-2, the major membrane protein in the secretory granule of the exocrine pancreas. (PMID: 8666297) Wong SM … Lowe AW (Gene 1996) 3 4 22 58
  5. The c.1275A>G putative chronic pancreatitis-associated synonymous polymorphism in the glycoprotein 2 (GP2) gene decreases exon 9 inclusion. (PMID: 19919903) Boulling A … Férec C (Molecular genetics and metabolism 2010) 3 22 58

Products for GP2 Gene

Sources for GP2 Gene

Content
Loading form....