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GP2 Gene

protein-coding   GIFtS: 56
GCID: GC16M020320

Glycoprotein 2 (Zymogen Granule Membrane)

  See GP2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glycoprotein 2 (Zymogen Granule Membrane)1 2
Pancreatic Zymogen Granule Membrane Protein GP-22 3
ZAP752 3
Pancreatic Secretory Granule Membrane Major Glycoprotein GP22
Pancreatic Zymogen Granule Membrane Associated Protein GP22

External Ids:    HGNC: 44411   Entrez Gene: 28132   Ensembl: ENSG000001693477   OMIM: 6029775   UniProtKB: P552593   

Export aliases for GP2 gene to outside databases

Previous GC identifers: GC16P019853 GC16M019752 GC16M020249 GC16M020288 GC16M020228 GC16M018858


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GP2 Gene:
GP2 (glycoprotein 2 (zymogen granule membrane)) is a protein-coding gene. Diseases associated with GP2 include ebola hemorrhagic fever, and vesiculitis. GO annotations related to this gene include antigen binding. An important paralog of this gene is OIT3.

Gene Wiki entry for GP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GP2 gene promoter:
         GCNF   COUP   HNF-4alpha2   HNF-4alpha1   Arnt   C/EBPalpha   CHOP-10   AREB6   COUP-TF   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGP2 promoter sequence
   Search Chromatin IP Primers for GP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12   Ensembl cytogenetic band:  16p12.3   HGNC cytogenetic band: 16p12.3

GP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GP2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M020320:  view genomic region     (about GC identifiers)

Start:
20,320,894 bp from pter      End:
20,339,130 bp from pter
Size:
18,237 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GP2_HUMAN, P55259 (See protein sequence)
Recommended Name: Pancreatic secretory granule membrane major glycoprotein GP2 precursor  
Size: 537 amino acids; 59480 Da
Subunit: Interacts with SYCN (By similarity)
Caution: It is uncertain whether Met-1 or Met-8 is the initiator
Sequence caution: Sequence=AAB19240.1; Type=Erroneous initiation;
Secondary accessions: A6NFM9 A6NJA8 Q13338 Q9UIF1
Alternative splicing: 4 isoforms:  P55259-1   P55259-2   P55259-3   P55259-4   

Explore the universe of human proteins at neXtProt for GP2: NX_P55259

Explore proteomics data for GP2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn65, Asn122, Asn134, Asn204, Asn216, Asn260, Asn291, Asn362
  • Modification sites at PhosphoSitePlus

  • See GP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001007241.2  NP_001007242.2  NP_001007243.2  NP_001493.2  

    ENSEMBL proteins: 
     ENSP00000304044   ENSP00000343861   ENSP00000370767   ENSP00000370765   ENSP00000460466  
     ENSP00000460124   ENSP00000461632   ENSP00000461061   ENSP00000460059  

    GP2 Human Recombinant Protein Products:

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    Novus Biologicals GP2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GP2
    Cloud-Clone Corp. Proteins for GP2

     
    Search eBioscience for Proteins for GP2 

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    LSBio Antibodies in human, mouse, rat for GP2

    GP2 Assay Products:

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    Search eBioscience for ELISAs for GP2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR017977 ZP_dom_CS
     IPR001507 ZP_dom

    Graphical View of Domain Structure for InterPro Entry P55259

    ProtoNet protein and cluster: P55259

    UniProtKB/Swiss-Prot: GP2_HUMAN, P55259
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 ZP domain


    Find genes that share domains with GP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for GP2:
    glycoprotein 2,zymogen granule membrane of pancreatic acinar cells,homolog to uromodulin,one membrane bound and
    one secreted form

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding IEA--
         
    Find genes that share ontologies with GP2           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gp2):
     endocrine/exocrine gland  no phenotypic analysis  normal 

    Find genes that share phenotypes with GP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GP2: Gp2tm1Soka Gp2tm1Awl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GP2

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    3 qRT-PCR Assays for microRNAs that regulate GP2:
    hsa-miR-204 hsa-miR-589* hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidGP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GP2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GP2_HUMAN, P55259: Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Secreted (By similarity).
    Note=Secreted after cleavage in the pancreatic juice
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    extracellular2
    endoplasmic reticulum1
    endosome1
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0016324apical plasma membrane IEA--
    GO:0031225anchored component of membrane IEA--

    Find genes that share ontologies with GP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GP2
    Interactions:

        GeneGlobe Interaction Network for GP2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for GP2 (P552593 ENSP000003707674) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANXA4P095253, ENSP000003778334I2D: score=2 STRING: ENSP00000377833
    AMY2AP047463I2D: score=1 
    SOX30ENSP000002650074STRING: ENSP00000265007
    TSSK3ENSP000003626344STRING: ENSP00000362634
    --ENSP000003775094STRING: ENSP00000377509
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002412antigen transcytosis by M cells in mucosal-associated lymphoid tissue IEA--

    Find genes that share ontologies with GP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GP2

    2 Novoseek inferred chemical compound relationships for GP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 18.9 3 8026640 (2), 10620373 (1)
    lipid 0 2 11853552 (2)



    Find genes that share compounds with GP2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GP2 gene (4 alternative transcripts): 
    NM_001007240.1  NM_001007241.1  NM_001007242.1  NM_001502.2  

    Unigene Cluster for GP2:

    Glycoprotein 2 (zymogen granule membrane)
    Hs.53985  [show with all ESTs]
    Unigene Representative Sequence: CR749600
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302555(uc002dgw.3) ENST00000341642 ENST00000381362(uc002dgv.3)
    ENST00000381360(uc002dgx.3 uc002dgy.3) ENST00000573897 ENST00000575582
    ENST00000574982 ENST00000572347 ENST00000572478 ENST00000575449 ENST00000575730

    miRNA
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    Block miRNA regulation of human, mouse, rat GP2 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate GP2:
    hsa-miR-204 hsa-miR-589* hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidGP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GP2
    Predesigned siRNA for gene silencing in human, mouse, rat GP2
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): GP2 (NM_001007240)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GP2
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GP2
      QuantiTect SYBR Green Assays in human, mouse, rat GP2
      QuantiFast Probe-based Assays in human, mouse, rat GP2

    Additional mRNA sequence: 

    AB035541.1 AB035542.1 AK293384.1 AK312277.1 BC032693.2 BX647831.1 BX648023.1 BX648201.1 
    BX649067.1 CR749600.1 D38225.1 U36221.1 

    23 DOTS entries:

    DT.101982440  DT.97816802  DT.97804375  DT.120660863  DT.100749704  DT.100027413  DT.100655216  DT.120660937 
    DT.120660944  DT.120660872  DT.120660903  DT.120660940  DT.120660942  DT.97782328  DT.100655303  DT.100795902 
    DT.120660867  DT.120660877  DT.120660904  DT.120660950  DT.120660968  DT.100641100  DT.100655417 

    Selected AceView cDNA sequences (see all 165):

    CA947148 BQ271857 AW873823 BM310899 CA777725 BX495079 BX498896 AA366051 
    BX499328 BU078090 CA941806 BM310600 BU952392 BX499295 CA771737 C06141 
    AA313020 AA366557 BX499218 BX647831 BX497999 U36221 BM264564 BX646729 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GP2 (see all 24)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^
    SP1:              -     -                                         -     -     -     -     -     -     -     -     -     -                                       
    SP2:                                                              -                                                     -                                       
    SP3:              -     -                                         -     -     -     -     -     -     -     -     -     -           -     -     -     -         
    SP4:              -     -                                         -     -     -     -     -     -     -     -     -     -                             -     -   
    SP5:              -     -                                         -     -     -     -     -     -     -     -     -     -                                       

    ExUns: 15a · 15b · 15c ^ 16a · 16b · 16c · 16d ^ 17 ^ 18a · 18b · 18c · 18d · 18e ^ 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c
    SP1:                                                                                                  -                                 
    SP2:                                                                                                  -                                 
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:              -     -     -                                                                                                         


    ECgene alternative splicing isoforms for GP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTGAAGAA
    GP2 Expression
    About this image


    GP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Ovary (Reproductive System)
             Granulosa Cells Primary Follicle
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts
    GP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.53985

    UniProtKB/Swiss-Prot: GP2_HUMAN, P55259
    Tissue specificity: Pancreatic secretory (zymogen) granule

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GP2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gp21 , 5 glycoprotein 2 (zymogen granule membrane)1, 5 74.12(n)1
    68.18(a)1
      7 (63.88 cM)5
    671331  NM_025989.31  NP_080265.21 
     1194425445 
    chicken
    (Gallus gallus)
    Aves ZPD6
    Gallus gallus zona pellucida protein D (ZPD), mRNA...
    23(a)
    1 → many
    11(520634-524598)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    40(a)
    1 → many
    GL343621.1(77126-92542)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-226h7.36
    si:ch211-226h7.3
    14(a)
    many ↔ many
    12(47238193-47270248) ENSDARG00000093365


    ENSEMBL Gene Tree for GP2 (if available)
    TreeFam Gene Tree for GP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GP2 gene
    OIT32  UMOD2  
    3 SIMAP similar genes for GP2 using alignment to 7 protein entries:     GP2_HUMAN (see all proteins):
    DKFZp779K0533    UMOD    TECTA

    Find genes that share paralogs with GP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GP2 (see all 496)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1168591741,2
    C,F--20324486(+) TGCCCG/ATGAGT 4 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1849787341,2
    --20324511(+) ATGTGC/TGATGC 4 -- ds50010--------
    rs118644051,2
    C,F,H--20324530(+) CTGCAT/ACTGTG 4 -- ds5001 ese39Minor allele frequency- A:0.11NS EA NA WA CSA 632
    rs108522401,2
    C,F,H--20324539(+) TGTCGA/GGTGCT 4 -- ds5001 ese325Minor allele frequency- G:0.06NS EA NA WA CSA 2356
    rs124442321,2
    C,F,H--20324583(+) CTTCAC/ACCATC 4 -- ds50016Minor allele frequency- A:0.16NS NA WA EA 596
    rs1380112601,2
    C--20324760(+) CCCAAG/TGATGT 4 -- ds50010--------
    rs1434504611,2
    --20325151(+) GGGCAC/GCCGAG 4 -- ut310--------
    rs106538841,2
    C--20325191(+) ttttc-/T/TT  
            
    ttttt
    8 -- ut31 trp31NA 2
    rs125969741,2
    C,F,H--20325276(+) TGCAAA/CCTCCA 4 -- ut31 ese32Minor allele frequency- C:0.38NA EA 126
    rs1153218001,2
    F--20325282(+) CTCCAC/TCCCCT 4 -- ut311Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for GP2 (20320894 - 20339130 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436835CNV Insertion17901297

    Human Gene Mutation Database (HGMD): GP2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GP2
    DNA2.0 Custom Variant and Variant Library Synthesis for GP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602977    OMIM disorders: --

    7 diseases for GP2:    
    About MalaCards
    ebola hemorrhagic fever    vesiculitis    swine influenza    lassa fever
    familial juvenile hyperuricaemic nephropathy    lymphocytic choriomeningitis    hemorrhagic fever

    4 diseases from the University of Copenhagen DISEASES database for GP2:
    Lassa fever     Vesiculitis     Ebola hemorrhagic fever     Lymphocytic choriomeningitis

    Find genes that share disorders with GP2           About GenesLikeMe

    4 Novoseek inferred disease relationships for GP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreas exocrine 68.5 3 8666297 (2), 1999417 (1)
    acute pancreatitis 15.4 2 8776176 (1), 15163232 (1)
    immunodeficiency 5.41 4 10838094 (1), 8642705 (1), 2229392 (1)
    virus infection 0 1 8621173 (1)

    Genetic Association Database (GAD): GP2
    Human Genome Epidemiology (HuGE) Navigator: GP2 (3 documents)

    Export disorders for GP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GP2 gene, integrated from 10 sources (see all 83):
    (articles sorted by number of sources associating them with GP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutational analysis of the gene encoding the zymogen granule membrane glycoprotein 2 (GP2) in patients with chronic pancreatitis. (PubMed id 19959969)1, 4, 9 Witt H....Drenth J.P. (Pancreas 2010)
    2. Molecular cloning and sequences of cDNAs encoding alpha (large) and beta (small) isoforms of human pancreatic zymogen granule membrane- associated protein GP2. (PubMed id 10760606)1, 2, 9 Fukuoka S. (Biochim. Biophys. Acta 2000)
    3. Sequence of the cDNA encoding human GP-2, the major membrane protein in the secretory granule of the exocrine pancreas. (PubMed id 8666297)1, 2, 9 Wong S.M.E. and Lowe A.W. (Gene 1996)
    4. Assignment of pancreatic zymogen granule membrane protein GP2 (GP2) to human chromosome band 9q21.11 to q21.2 by in situ hybridization. (PubMed id 9605860)1, 3, 9 Fukuoka S.I....Takahashi E. (Cytogenet. Cell Genet. 1997)
    5. Genetic analysis of the glycoprotein 2 gene in patients with chronic pancreatitis. (PubMed id 20335779)1, 4 Masson E....FAcrec C. (Pancreas 2010)
    6. Incorporation of the pancreatic membrane protein GP-2 into secretory granules in exocrine but not endocrine cells. (PubMed id 7503984)1, 9 Hoops T.C....Rindler M.J. (J. Biol. Chem. 1993)
    7. Interaction of syncollin with GP-2, the major membrane protein of pancreatic zymogen granules, and association with lipid microdomains. (PubMed id 11853552)1, 9 Kalus I....Schrader M. (Biochem. J. 2002)
    8. Specific interactions of pancreatic amylase at acidic pH. Amylase and the major protein of the zymogen granule membrane (GP-2) bind to immobilized or polymerized amylase. (PubMed id 1284286)1, 9 Jacob M....LeBel D. (Biochem. Cell Biol. 1992)
    9. The c.1275A&gt;G putative chronic pancreatitis-associated synonymous polymorphism in the glycoprotein 2 (GP2) gene decreases exon 9 inclusion. (PubMed id 19919903)1, 9 Boulling A....FAcrec C. (Mol. Genet. Metab. 2010)
    10. Meta-analysis identifies common variants associated with body mass index in east Asians. (PubMed id 22344219)1 Wen W....Shu X.O. (Nat. Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2813 HGNC: 4441 AceView: GP2 Ensembl:ENSG00000169347 euGenes: HUgn2813
    ECgene: GP2 H-InvDB: GP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GP2 gene:
    Search GeneIP for patents involving GP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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