Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GP1BA Gene

protein-coding GIFtS: 65
GCID: GC17P004835

glycoprotein Ib (platelet), alpha polypeptide

(Previous symbol: GP1B)

Explore 70 diseases affiliated with
GP1BA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Glycoprotein Ib (Platelet), Alpha Polypeptide¹ ²		CD42B²
GP1B¹ ²		CD42b-Alpha¹
Antigen CD42b-Alpha² ³		DBPLT3²
GPIbA² ³		VWDP²
GP-Ib Alpha² ³		Platelet Glycoprotein Ib Alpha Chain²
CD42b¹		Platelet Membrane Glycoprotein 1b-Alpha Subunit²
BDPLT1²		GPIb-Alpha¹
BDPLT3²		CD42b Antigen³
BSS²		Glycoprotein Ibalpha³

External Ids:	HGNC: 4439¹	Entrez Gene: 2811²	Ensembl: ENSG00000185245⁷	OMIM: 606672⁵	UniProtKB: P07359³

Export aliases for GP1BA gene to outside databases

Previous GC identifers: GC17P005255 GC17P005173 GC17P004780 GC17P005036 GC17P004776

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GP1BA:

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a

beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The

complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein

IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to

vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to

enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms

and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and

platelet-type von Willebrand disease. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: GP1BA_HUMAN, P07359

Function: GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to

the A1 domain of vWF, which is already bound to the subendothelium

Gene Wiki entry for GP1BA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GP1BA gene promoter:
E2F-4 E2F-3a AP-1 ATF-2 E2F-2 E2F E2F-1 c-Jun NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GP1BA promoter sequence

Search SABiosciences Chromatin IP Primers for GP1BA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GP1BA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17pter-p12 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17pter-p12

GP1BA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GP1BA gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P004835: view genomic region (about GC identifiers)

Start:	4,835,592 bp from pter	End:	4,838,325 bp from pter
Size:	2,734 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GP1BA_HUMAN, P07359 (See protein sequence)

Recommended Name: Platelet glycoprotein Ib alpha chain precursor

Size: 626 amino acids; 68955 Da

Subunit: Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX is complexed with the GP-Ib heterodimer via a

non covalent linkage. Interacts with FLNB

Subcellular location: Membrane; Single-pass type I membrane protein

Miscellaneous: Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the

platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein

Miscellaneous: Binding sites for vWF and thrombin (the latter site with unknown function) are in the N-terminal part of

the molecule

6/13 PDB 3D structures from and Proteopedia for GP1BA (see all 13):

1GWB (3D)

1K13 (3D)

1M0Z (3D)

1M10 (3D)

1OOK (3D)

1P8V (3D)

Secondary accessions: Q14441 Q16469 Q8N1F3 Q8NG39 Q9HDC7 Q9UEK1 Q9UQS4

Explore the universe of human proteins at neXtProt for GP1BA: NX_P07359

Post-translational modifications:

Glycocalicin, which is approximately coextensive with the extracellular part of the molecule, is cleaved off by calpain

during platelet lysis¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P07359

GP1BA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000164.5

ENSEMBL proteins:

ENSP00000329380

Reactome Protein details: P07359
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for GP1BA (CD42b/GPIb alpha)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: GP1BA OriGene Custom Protein Services for GP1BA
	GenScript Custom Purified and Recombinant Proteins Services for GP1BA
	Novus Biologicals GP1BA Proteins Novus Biologicals GP1BA Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	3353370
GO:0016020	membrane	IDA	15297306
GO:0031362	colocalizes with anchored to external side of plasma membrane	IDA	19443707

GP1BA for ontologies About GeneDecksing

GP1BA Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of GP1BA
	R&D Systems Antibodies for GP1BA (CD42b/GPIb alpha)
	OriGene Antibodies (see all 2): GP1BA OriGene Custom Antibody Services for GP1BA
	GenScript Custom Superior Antibodies Services for GP1BA
	Novus Biologicals GP1BA Antibodies
	Abcam antibodies for GP1BA
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for GP1BA

Assay Products for GP1BA:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GP1BA
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GP1BA for domains About GeneDecksing

4 InterPro domains/families:

IPR000483 Cys-rich_flank_reg_C

IPR001611 Leu-rich_rpt

IPR003591 Leu-rich_rpt_typical-subtyp

IPR000372 LRR-contain_N

Graphical View of Domain Structure for InterPro Entry P07359

ProtoNet protein and cluster: P07359

2 Blocks protein families:

IPB000483 Cysteine-rich flanking region

IPB001611 Leucine-rich repeat signature

UniProtKB/Swiss-Prot: GP1BA_HUMAN, P07359

Similarity: Contains 7 LRR (leucine-rich) repeats

Similarity: Contains 1 LRRCT domain

Similarity: Contains 1 LRRNT domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GP1BA_HUMAN, P07359

Function: GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to

the A1 domain of vWF, which is already bound to the subendothelium

Genatlas biochemistry entry for GP1BA:

platelet glycoprotein Ib,alpha (143kDa),linked to GP1BB through disulfide bonds in von Willebrand receptor

miRNA Products:		OriGene 3'-UTR Clone: GP1BA Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GP1BA
		1 QIAGEN miScript miRNA Assays for microRNA that regulate GP1BA:
		hsa-miR-550a
		SwitchGear 3'UTR luciferase reporter plasmid: GP1BA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GP1BA (see all 7) OriGene shRNA RFP: GP1BA OriGene siRNA: GP1BA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GP1BA

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for GP1BA

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GP1BA (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GP1BA (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GP1BA (NM_000173)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GP1BA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GP1BA

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GP1BA
		Search LifeMap BioReagents cell lines for GP1BA

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GP1BA

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15039442
GO:0015057	thrombin receptor activity	TAS	12855810

GP1BA for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for GP1BA:

Decreased number of cells in m

Animal Models:
Mouse knock-out Gp1ba^tm1Ware for GP1BA
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Gp1ba):

cellular

hematopoietic system

homeostasis/metabolism

GP1BA for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Formation of Fibrin Clot (Clotting Cascade)

	Formation of Fibrin Clot (Clotting Cascade)	1.00			Blood Coagulation Signaling Pathways	0.51
	Intrinsic Pathway	0.59

GP1b signaling involves c-Src

	GP1b signaling involves c-Src	1.00			Platelet Adhesion to exposed collagen	0.36
	GP1b-IX-V activation signalling	0.60

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

amb2 Integrin signaling

amb2 Integrin signaling

1.00

Hematopoietic cell lineage

Hematopoietic cell lineage

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for GP1BA

Blood Coagulation Signaling Pathways

1 BioSystems Pathway for GP1BA

amb2 Integrin signaling

5/8 Reactome Pathways for GP1BA (see all 8)

	GP1b signaling involves c-Src
	Hemostasis
	Platelet Adhesion to exposed collagen
	Formation of Fibrin Clot (Clotting Cascade)
	GP1b-IX-V activation signalling

2 Kegg Pathways (Kegg details for GP1BA):

	ECM-receptor interaction
	Hematopoietic cell lineage

GP1BA for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GP1BA

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/31 Interacting proteins for GP1BA (P07359^{1, 2, 3} ENSP00000329380⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 31)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
VWF	P04275¹^,²^,³, ENSP00000261405⁴	EBI-297082,EBI-981819 MINT-17868 MINT-24838 I2D: score=3 STRING: ENSP00000261405
YWHAB	P31946²^,³, ENSP00000300161⁴	MINT-8009042 I2D: score=1 STRING: ENSP00000300161
YWHAE	P62258²^,³, ENSP00000264335⁴	MINT-8009049 I2D: score=1 STRING: ENSP00000264335
YWHAG	P61981²^,³, ENSP00000306330⁴	MINT-8009063 I2D: score=1 STRING: ENSP00000306330
YWHAZ	P63104²^,³, ENSP00000309503⁴	MINT-8009035 MINT-8009582 I2D: score=1 STRING: ENSP00000309503

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000902	cell morphogenesis	IEA	--
GO:0007155	cell adhesion	IDA	9410473
GO:0007166	cell surface receptor signaling pathway	TAS	3353370
GO:0007596	blood coagulation	TAS	--
GO:0007597	blood coagulation, intrinsic pathway	TAS	--

GP1BA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GP1BA for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GP1BA

1 DrugBank Compound for GP1BA About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Alpha-D-Mannose	--	3458-28-4	target	--	17139284 17016423

10/40 Novoseek chemical compound relationships for GP1BA gene (see all 40) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ristocetin	88.9	13	15630508 (3), 2012763 (1), 15809291 (1), 18339097 (1) (see all 9)
fibrinogen	62.3	29	11024046 (3), 10706934 (2), 10579727 (2), 10660541 (2) (see all 19)
lamifiban	59.8	2	12719784 (1), 14961148 (1)
adp	56	23	12008098 (2), 12871418 (2), 10213176 (1), 18499605 (1) (see all 14)
hirudin	51	5	11024046 (1), 11307817 (1), 19591434 (1)
convulxin	46.6	17	12881531 (11), 15320694 (1)
desmopressin	33.5	1	10063996 (1)
cytochalasin d	32.1	3	15946527 (1), 11071645 (1), 11323024 (1)
kininogen	31.3	1	1318546 (1)
abciximab	24.5	3	16261288 (1), 18084279 (1)

Search CenterWatch for drugs/clinical trials and news about GP1BA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GP1BA gene:

NM_000173.5

Unigene Cluster for GP1BA:

Glycoprotein Ib (platelet), alpha polypeptide

Hs.1472 [show with all ESTs]

Unigene Representative Sequence: NM_000173

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000329125(uc021tnz.1)

miRNA Products:		OriGene 3'-UTR Clone: GP1BA Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GP1BA
		1 QIAGEN miScript miRNA Assays for microRNA that regulate GP1BA:
		hsa-miR-550a
		SwitchGear 3'UTR luciferase reporter plasmid: GP1BA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GP1BA (see all 7) OriGene shRNA RFP: GP1BA OriGene siRNA: GP1BA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GP1BA

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GP1BA (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GP1BA (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GP1BA (NM_000173)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GP1BA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GP1BA

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GP1BA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat GP1BA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GP1BA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GP1BA

Additional cDNA sequence:

BC027955.1 J02940.1

2 DOTS entries:

DT.97818268 DT.103690

11 AceView cDNA sequences:

BX280733 BI767765 BE463855 BM971661 NM_000173 BC027955 AW950474 J02940

AW950469 AA333774 BF360177

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GP1BA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAACCACA

About this image

GP1BA expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Endothelial Cells

Blood Brain Barrier, Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Megakaryocytes-like cells (Generation of hemato...)

Platelets and megakaryocytes like cells (Generation of hemato...)

See GP1BA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GP1BA

SOURCE GeneReport for Unigene cluster: Hs.1472

SABiosciences Custom PCR Arrays for GP1BA

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GP1BA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat GP1BA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GP1BA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GP1BA

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GP1BA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for GP1BA gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC100857333¹	platelet glycoprotein Ib alpha chain-like	52.32(n) 39.66(a)		100857333 XM_003642839.1 XP_003642887.1
zebrafish (Danio rerio)	Actinopterygii	si:ch211-191d15.2⁶ BX897714.2⁶ (see all 3)	--	33(a) 23(a) (see all 3)	1 ↔ many 1 ↔ many (see all 3)	5(22224981-22225642) 25(19532734-19536049)

ENSEMBL Gene Tree for GP1BA (if available)
TreeFam Gene Tree for GP1BA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GP1BA gene

LRG1²

GP1BA for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: GP1BA_HUMAN, P07359

Polymorphism: Position 161 is associated with platelet-specific alloantigen Siba. Siba(-) has Thr-161 and Siba(+) has

Met-161. Siba is involved in neonatal alloimmune thrombocytopenia (NATP)

Polymorphism: Polymorphisms arise from a variable number of tandem 13-amino acid repeats of S-E-P-A-P-S-P-T-T-P-E-P-T

in the mucin-like macroglycopeptide (Pro/Thr-rich) domain. Allele D (shown here) contains one repeat starting at

position 415, allele C contains two repeats, allele B contains three repeats and allele A contains four repeats.

Allele B is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2243087^1,2	C,F,H,	--	4721935(+)	`GTTCAG/TCTTTG`	1	--	us2k¹		14		NS CSA WA NA	1956
rs2243108^1,2	F,H,	--	4722180(+)	`acttcG/Aggaag`	1	--	us2k¹		7		NS EA NA	1218
rs71368526^1,2	C,F,	--	4722526(+)	`AGCATT/CAAAGA`	1	--	us2k¹		3		NA	124
rs2243089^1,2	C,F,H,	--	4722741(+)	`TGGCAC/TGATCT`	1	--	us2k¹		9		NS NA EA	554
rs2243091^1,2	C,F,	--	4722921(+)	`tgatcC/Tgcccg`	1	--	us2k¹		5		NA NS WA	100
rs2243092^1,2	C,F,	--	4722942(+)	`ccaaaG/Attctg`	1	--	us2k¹		6		MN NA NS WA	284
rs3887887^1,2	C,F,H,	--	4722968(+)	`GCCACA/GCGCCC`	1	--	us2k¹ tfbs³		3		NS NA	172
rs56337033^1,2		--	4723253(+)	`GAAGAC/TGCTCT`	1	--	ut5¹		0	--	--	--	--
rs2243109^1,2	C,F,H,	--	4723319(+)	`AGAGGG/AGTCTG`	1	--	int¹ trp³		6		NS NA	1168
rs13306411^1,2	C,	--	4723781(+)	`CCAAGC/TTCCAG`	2	L F	mis¹ ese³		2		NA	4

HapMap Linkage Disequilibrium report for GP1BA (4835592 - 4838325 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for GP1BA
2 CNVs: 4987 4986
1 Indel: 58796
Human Gene Mutation Database (HGMD): GP1BA

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GP1BA

DNA2.0 Custom Variant and Variant Library Synthesis for GP1BA

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GP1BA for disorders           About GeneDecksing

OMIM gene information: 606672
OMIM disorders: 231200  177820  258660  153670
UniProtKB/Swiss-Prot: GP1BA_HUMAN, P07359

Genetic variations in GP1BA may be a cause of susceptibility to non-arteritic anterior ischemic optic

neuropathy (NAION) [MIM:258660]. NAION is an ocular disease due to ischemic injury to the optic nerve. It usually

affects the optic disk and leads to visual loss and optic disk swelling of a pallid nature. Visual loss is usually

sudden, or over a few days at most and is usually permanent, with some recovery possibly occurring within the first

weeks or months. Patients with small disks having smaller or non-existent cups have an anatomical predisposition for

non-arteritic anterior ischemic optic neuropathy. As an ischemic episode evolves, the swelling compromises

circulation, with a spiral of ischemia resulting in further neuronal damage

Defects in GP1BA are a cause of Bernard-Soulier syndrome (BSS) [MIM:231200]; also known as giant platelet

disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency

Defects in GP1BA are the cause of Bernard-Soulier syndrome A2, autosomal dominant (BSSA2) [MIM:153670]. A

coagulation disorder characterized by mild to moderate bleeding tendency, thrombocytopenia, and an increased mean

platelet volume. Some individuals have no symptoms. Mild bleeding tendencies manifest as epistaxis, gingival bleeding,

menorrhagia, easy bruising, or prolonged bleeding after dental surgery

Defects in GP1BA are the cause of pseudo-von Willebrand disease (VWDP) [MIM:177820]. A bleeding disorder is

caused by an increased affinity of GP-Ib for soluble vWF resulting in impaired hemostatic function due to the removal

of vWF from the circulation

20/70 diseases for GP1BA (see all 70): About MalaCards

bernard-soulier syndrome von willebrand's disease bernard-soulier syndrome, benign autosomal dominant nonarteritic anterior ischemic optic neuropathy

bernard-soulier syndrome type a thrombosis pseudo-von willebrand disease heparin-induced thrombocytopenia

ischemic optic neuropathy glanzmann's thrombasthenia disseminated intravascular coagulation splenic sequestration

patent ductus arteriosus abdominal aortic aneurysm thrombasthenia aortic aneurysm

coronary heart disease myocardial infarction polycythemia vera acute chest syndrome

3 diseases from the University of Copenhagen DISEASES database for GP1BA:

Bernard-Soulier syndrome Thrombocytopenia Von Willebrand's disease

10/35 Novoseek disease relationships for GP1BA gene (see all 35) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
bernard-soulier syndrome	96.4	30	11776304 (2), 19448529 (2), 18791947 (2), 7949089 (1) (see all 24)
von willebrand disease, platelet-type	94.9	17	15705799 (2), 8950788 (1), 19951970 (1), 10713059 (1) (see all 16)
platelet disorder	76.5	3	15550031 (1), 19067792 (1)
coagulopathy	73.6	9	12529755 (1), 15705799 (1), 15978109 (1), 19951970 (1) (see all 8)
thrombocytopenia	69.2	23	8249898 (2), 8698134 (2), 9657431 (2), 10642807 (1) (see all 15)
von willebrand disease	68.8	4	18805962 (1), 10063996 (1), 19085651 (1), 15039442 (1)
bleeding tendency	64.3	1	10235425 (1)
abnormal platelets	63.3	1	9226170 (1)
glanzmann thrombasthenia	57	1	12871468 (1)
macrocytosis	53.5	2	19067792 (1)

Genatlas disease: GP1BA

Bernard-Soulier syndrome;giant platelet syndrome,including Bolzano type,associated in some cases with GP9 and GP5

deficiencies

Genetic Association Database (GAD): GP1BA
Human Genome Epidemiology (HuGE) Navigator: GP1BA (87 documents)

Export disorders for GP1BA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for GP1BA gene, integrated from 9 sources (see all 536):
(articles sorted by number of sources associating them with GP1BA)

Utopia: connect your pdf to the dynamic
world of online information

Cys209 Ser mutation in the platelet membrane glycoprotein Ib alpha gene is associated with Bernard-Soulier syndrome. (PubMed id 7819107)^{1, 2, 4, 9} Simsek S.... Gallardo D. (1994)
Pseudo-von Willebrand disease: a mutation in the platelet glycoprotein Ib alpha gene associated with a hyperactive surface receptor. (PubMed id 8384898)^{1, 2, 4, 9} Russell S.D. and Roth G.J. (1993)
Tissue factor and platelet glycoprotein Ib-alpha alleles are associated with age at first coronary bypass operation. (PubMed id 14639140)^{1, 4, 9} Donahue B.S....George A.L. (2003)
A three-base deletion removing a leucine residue in a leucine-rich repeat of platelet glycoprotein Ib alpha associated with a variant of Bernard-Soulier syndrome (Nancy I). (PubMed id 7873390)^{1, 2, 9} de la Salle C.... Cazenave J.-P. (1995)
Mutation of leucine-57 to phenylalanine in a platelet glycoprotein Ib alpha leucine tandem repeat occurring in patients with an autosomal dominant variant of Bernard-Soulier disease. (PubMed id 1730088)^{1, 2, 9} Miller J.L.... Cunningham D. (1992)
The largest variant of platelet glycoprotein Ib alpha has four tandem repeats of 13 amino acids in the macroglycopeptide region and a genetic linkage with methionine145. (PubMed id 7632942)^{1, 2, 9} Ishida F....Furuta S. (1995)
Identification of a novel point mutation in platelet glycoprotein Ibalpha, Gly to Ser at residue 233, in a Japanese family with platelet-type von Willebrand disease. (PubMed id 14521605)^{1, 2, 9} Matsubara Y.... Ikeda Y. (2003)
Molecular modeling of the seven tandem leucine-rich repeats within the ligand-binding region of platelet glycoprotein Ib alpha. (PubMed id 11858495)^{1, 2, 9} Whisstock J.C.... Berndt M.C. (2002)
Compound heterozygosity of the GPIbalpha gene associated with Bernard-Soulier syndrome. (PubMed id 11776304)^{1, 4, 9} Gonzalez-Manchon C....Parrilla R. (2001)
Molecular characterization of two mutations in platelet glycoprotein (GP) Ib alpha in two Finnish Bernard-Soulier syndrome families. (PubMed id 10089893)^{1, 2, 9} Koskela S.... Kekomaki R. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2811	HGNC: 4439	AceView: GP1BA	Ensembl:ENSG00000185245	euGenes: HUgn2811
ECgene: GP1BA	Kegg: 2811	H-InvDB: GP1BA

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GP1BA	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/GP1BA
SeattleSNPs	http://pga.gs.washington.edu/data/gp1ba/

Intellectual Property for GP1BA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for GP1BA gene:
Search GeneIP for patents involving GP1BA

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of GP1BA
	Browse Small Molecules at EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for GP1BA (CD42b/GPIb alpha)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for GP1BA (CD42b/GPIb alpha)

	OriGene Antibodies for GP1BA		OriGene shRNA RFP for GP1BA
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GP1BA		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GP1BA
	OriGene Protein Over-expression Lysate for GP1BA		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for GP1BA		OriGene 3'-UTR Clone for GP1BA
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GP1BA		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GP1BA
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for GP1BA		OriGene Custom Protein Services for GP1BA
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GP1BA
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GP1BA
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GP1BA
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GP1BA
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GP1BA
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GP1BA

	GenScript Custom Purified and Recombinant Proteins Services for GP1BA		GenScript cDNA clones with any tag delivered in your preferred vector for GP1BA
	GenScript Custom Assay Services for GP1BA		GenScript Custom Superior Antibodies Services for GP1BA
	GenScript Custom overexpressing Cell Line Services for GP1BA		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in GP1BA promoter
	Search Chromatin IP Primers for GP1BA
	RT² qPCR Primer Assay in human, mouse, rat GP1BA
	GNC Network for GP1BA
	SABiosciences Custom PCR Arrays for GP1BA

Search Tocris compounds for GP1BA

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	GP1BA antibodies
	GP1BA proteins
	GP1BA lysates

	Antibodies for GP1BA
	See all of Abcam's Antibodies, Kits and Proteins for GP1BA
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for GP1BA

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GP1BA

	SwitchGear 3'UTR luciferase reporter plasmids for GP1BA
	SwitchGear Promoter luciferase reporter plasmids for GP1BA

ThermoFisher Antibodies for GP1BA

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GP1BA

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes GP1BA gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

GP1BA Gene

glycoprotein Ib (platelet), alpha polypeptide

Aliases
for GP1BA gene

Summaries
for GP1BA gene

Genomic Views
for GP1BA gene

Proteins
for GP1BA gene

Protein Domains /
Families
for GP1BA gene

Function
for GP1BA gene

Pathways & Interactions
for GP1BA gene

Drugs & Compounds
for GP1BA gene

Transcripts
for GP1BA gene

Expression
for GP1BA gene

Orthologs
for GP1BA gene

Paralogs
for GP1BA gene

Genomic Variants
for GP1BA gene

Disorders / Diseases
for GP1BA gene

Publications
for GP1BA gene

External Searches for GP1BA gene

Genome Databases showing GP1BA gene

Other Databases showing GP1BA gene

Specialized Databases showing GP1BA gene

Intellectual Property
for GP1BA gene

Products
for GP1BA gene

View Random Gene

Thrombocytosis
Cirrhosis
BREAST CARCINOMA
ABNORMAL PLATELETS
sepsis
Erythroleukemia
coagulopathy
Hyperlipidemia
Diabetes Mellitus
Breast Cancer
Purpura Thrombocytopenic Idiopathic
VON WILLEBRAND DISEASE, PLATELET-TYPE
platelet disorder
BLEEDING TENDENCY
Aneurysm
Thrombocytopenia
Myocardial Infarction
Coronary Artery Disease
Pathological Processes
von Willebrand Disease
Macrocytosis
ARTERIAL THROMBOSIS
Bleeding
solid tumor
immunodeficiency
Glanzmann Thrombasthenia
STROKE
Bernard-Soulier Syndrome
Vascular Diseases
Anemia Aplastic
Tumors
Thrombosis
Necrosis
Myelodysplastic Syndromes
Coronary Heart Disease

Advanced Search

Export list of displayed genes

GP1BA Gene

glycoprotein Ib (platelet), alpha polypeptide

Aliasesfor GP1BA gene

Summariesfor GP1BA gene

Genomic Viewsfor GP1BA gene

Proteinsfor GP1BA gene

Protein Domains /Familiesfor GP1BA gene

Functionfor GP1BA gene

Pathways & Interactionsfor GP1BA gene

Drugs & Compoundsfor GP1BA gene

Transcriptsfor GP1BA gene

Expression for GP1BA gene

Orthologsfor GP1BA gene

Paralogsfor GP1BA gene

Genomic Variantsfor GP1BA gene

Disorders / Diseasesfor GP1BA gene

Publicationsfor GP1BA gene

External Searches for GP1BA gene

Genome Databases showing GP1BA gene

Other Databases showing GP1BA gene

Specialized Databases showing GP1BA gene

Intellectual Propertyfor GP1BA gene

Productsfor GP1BA gene

View Random Gene

Aliases
for GP1BA gene

Summaries
for GP1BA gene

Genomic Views
for GP1BA gene

Proteins
for GP1BA gene

Protein Domains /
Families
for GP1BA gene

Function
for GP1BA gene

Pathways & Interactions
for GP1BA gene

Drugs & Compounds
for GP1BA gene

Transcripts
for GP1BA gene

Expression
for GP1BA gene

Orthologs
for GP1BA gene

Paralogs
for GP1BA gene

Genomic Variants
for GP1BA gene

Disorders / Diseases
for GP1BA gene

Publications
for GP1BA gene

Intellectual Property
for GP1BA gene

Products
for GP1BA gene