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GOT2 Gene

protein-coding   GIFtS: 70
GCID: GC16M058741

Glutamic-Oxaloacetic Transaminase 2, Mitochondrial

(Previous names: glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate...)
  See GOT2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutamic-Oxaloacetic Transaminase 2, Mitochondrial1 2     Transaminase A2 3
Kynurenine Aminotransferase IV1 2 3     FABP-12 3
Glutamic-Oxaloacetic Transaminase 2, Mitochondrial (Aspartate
Aminotransferase 2)1 2
     FABPpm2 3
Aspartate Aminotransferase 21 2     mAspAT2 3
Aspartate Transaminase 21 2     EC 2.6.1.13 8
Fatty Acid-Binding Protein2 3     KAT42
Glutamate Oxaloacetate Transaminase 22 3     KATIV2
Kynurenine Aminotransferase 42 3     Aspartate Aminotransferase, Mitochondrial2
Kynurenine--Oxoglutarate Transaminase 42 3     mitAAT2
Kynurenine--Oxoglutarate Transaminase IV2 3     EC 2.6.1.73
Plasma Membrane-Associated Fatty Acid-Binding Protein2 3     EC 2.6.18

External Ids:    HGNC: 44331   Entrez Gene: 28062   Ensembl: ENSG000001251667   OMIM: 1381505   UniProtKB: P005053   

Export aliases for GOT2 gene to outside databases

Previous GC identifers: GC16M049137 GC16M058827 GC16M058475 GC16M058516 GC16M057298 GC16M044606


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GOT2 Gene:
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and
inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and
the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2013)

GeneCards Summary for GOT2 Gene:
GOT2 (glutamic-oxaloacetic transaminase 2, mitochondrial) is a protein-coding gene. Diseases associated with GOT2 include reye syndrome, and exanthem. GO annotations related to this gene include L-phenylalanine:2-oxoglutarate aminotransferase activity and pyridoxal phosphate binding. An important paralog of this gene is GOT1.

UniProtKB/Swiss-Prot: AATM_HUMAN, P00505
Function: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic
acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and
cytosol. Facilitates cellular uptake of long-chain free fatty acids

Gene Wiki entry for GOT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GOT2 gene promoter:
         MIF-1   NF-kappaB   GATA-2   AREB6   SRY   POU2F1a   NF-kappaB2   FOXJ2 (long isoform)   FOXJ2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGOT2 promoter sequence
   Search Chromatin IP Primers for GOT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GOT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q21

GOT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GOT2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M058741:  view genomic region     (about GC identifiers)

Start:
58,741,035 bp from pter      End:
58,768,261 bp from pter
Size:
27,227 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AATM_HUMAN, P00505 (See protein sequence)
Recommended Name: Aspartate aminotransferase, mitochondrial precursor  
Size: 430 amino acids; 47518 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer
Miscellaneous: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes
Secondary accessions: Q53FL3 Q9BWA3

Explore the universe of human proteins at neXtProt for GOT2: NX_P00505

Explore proteomics data for GOT2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys122, Lys396
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GOT2 (P00505) (see all 19)
     LDKEYLP  DPILGVT  MGPPDPI  ADEAKRV 


    See GOT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273149.1  NP_002071.2  

    ENSEMBL proteins: 
     ENSP00000245206   ENSP00000394100   ENSP00000456205  
    Reactome Protein details: P00505

    GOT2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GOT2
    GenScript Custom Purified and Recombinant Proteins Services for GOT2
    Novus Biologicals GOT2 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GOT2
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GOT2 

    GOT2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for GOT2
    OriGene Custom Antibody Services for GOT2
    Novus Biologicals GOT2 Antibodies
    Abcam antibodies for GOT2
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for GOT2
    LSBio Antibodies in human, mouse, rat for GOT2

    GOT2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GOT2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for GOT2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR004838 NHTrfase_class1_PyrdxlP-BS
     IPR004839 Aminotransferase_I/II
     IPR015424 PyrdxlP-dep_Trfase
     IPR000796 Asp_trans
     IPR015421 PyrdxlP-dep_Trfase_major_sub1

    Graphical View of Domain Structure for InterPro Entry P00505

    ProtoNet protein and cluster: P00505

    3 Blocks protein domains:
    IPB000796 Aspartate aminotransferase signature
    IPB004838 Aminotransferase
    IPB004839 Aminotransferase


    UniProtKB/Swiss-Prot: AATM_HUMAN, P00505
    Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family


    Find genes that share domains with GOT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AATM_HUMAN, P00505
    Function: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic
    acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and
    cytosol. Facilitates cellular uptake of long-chain free fatty acids
    Catalytic activity: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate
    Catalytic activity: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
    Induction: Up-regulated by long-time exposure to alcohol

         Genatlas biochemistry entry for GOT2:
    glutamic-oxaloacetic transaminase 2,mitochondrial (aspartate aminotransferase 1)

         Enzyme Numbers (IUBMB): EC 2.6.1.11 2 EC 2.6.12 EC 2.6.1.71

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004069L-aspartate:2-oxoglutarate aminotransferase activity ISS--
    GO:0016212kynurenine-oxoglutarate transaminase activity IEA--
    GO:0030170pyridoxal phosphate binding IEA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0080130L-phenylalanine:2-oxoglutarate aminotransferase activity IEA--
         
    Find genes that share ontologies with GOT2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GOT2:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GOT2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GOT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GOT2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GOT2

    miRNA
    Products:
        
    miRTarBase miRNAs that target GOT2:
    hsa-mir-16-5p (MIRT051208), hsa-mir-17-3p (MIRT050779), hsa-mir-196a-5p (MIRT048281), hsa-mir-93-3p (MIRT038877), hsa-mir-342-3p (MIRT043698), hsa-mir-484 (MIRT041650), hsa-mir-92a-3p (MIRT049202)

    Block miRNA regulation of human, mouse, rat GOT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GOT2 (see all 27):
    hsa-miR-320a hsa-miR-30c hsa-miR-181c hsa-miR-4318 hsa-miR-139-5p hsa-miR-30d hsa-miR-30a hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidGOT2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GOT2
    Predesigned siRNA for gene silencing in human, mouse, rat GOT2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GOT2

    Clone
    Products:
         
    OriGene clones in human, mouse for GOT2 (see all 8)
    OriGene ORF clones in mouse, rat for GOT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GOT2 (NM_002080)
    Sino Biological Human cDNA Clone for GOT2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GOT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GOT2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GOT2
    Browse ESI BIO Cell Lines and PureStem Progenitors for GOT2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AATM_HUMAN, P00505: Mitochondrion matrix. Cell membrane. Note=Exposure to alcohol promotes translocation to the
    cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    plasma membrane5
    cytosol3
    extracellular3
    peroxisome3
    cytoskeleton2
    endoplasmic reticulum2
    nucleus2
    vacuole1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ISS--
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005759mitochondrial matrix TAS--
    GO:0005886plasma membrane IDA9537447
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with GOT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GOT2 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Phenylalanine metabolism
    Phenylalanine metabolism0.36
    Phenylalanine, tyrosine and tryptophan biosynthesis0.00
    Tyrosine metabolism0.36
    phenylalanine degradation IV0.00
    phenylalanine utilization0.33
    2Glucose metabolism
    Glucose metabolism0.44
    malate-aspartate shuttle0.00
    Gluconeogenesis0.44
    3Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    tryptophan degradation via kynurenine0.00
    Amino acid synthesis and interconversion (transamination)0.00
    4Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    5Carbon metabolism
    Carbon metabolism0.38
    2-Oxocarboxylic acid metabolism0.00
    Biosynthesis of amino acids0.38


    Find genes that share SuperPaths with GOT2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected BioSystems Pathways for GOT2 (see all 6)
        malate-aspartate shuttle
    Alanine and aspartate metabolism
    Glycolysis and Gluconeogenesis
    phenylalanine degradation IV
    tryptophan degradation via kynurenine


    2 Reactome Pathways for GOT2
        Gluconeogenesis
    Amino acid synthesis and interconversion (transamination)

    1 PharmGKB Pathway for GOT2
        Valproic Acid Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for GOT2) (see all 11):
        Alanine, aspartate and glutamate metabolism
    Cysteine and methionine metabolism
    Arginine and proline metabolism
    Tyrosine metabolism
    Phenylalanine metabolism

        Pathway & Disease-focused RT2 Profiler PCR Array including GOT2: 
              Amino Acid Metabolism I in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GOT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GOT2 (P005052, 3 ENSP000002452064) via UniProtKB, MINT, STRING, and/or I2D (see all 148)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    THOC7Q6I9Y22, 3, ENSP000002958994MINT-63341 I2D: score=5 STRING: ENSP00000295899
    GAPDHP044062, 3, ENSP000002292394MINT-8256338 I2D: score=2 STRING: ENSP00000229239
    GLRXP357542, 3, ENSP000002378584MINT-8256514 I2D: score=2 STRING: ENSP00000237858
    ENSG00000206435P305043I2D: score=1 
    ENSG00000206452P305043I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006006glucose metabolic process TAS--
    GO:0006094gluconeogenesis TAS--
    GO:00061032-oxoglutarate metabolic process ISS--
    GO:0006107oxaloacetate metabolic process IEA--

    Find genes that share ontologies with GOT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GOT2 (AATM)

    Selected HMDB Compounds for GOT2 (see all 16)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Mercaptopyruvic acid3-Mercaptopyruvate (see all 13)2464-23-5--
    3-Sulfinoalanine3-Sulphino-L-alanine (see all 9)1115-65-7--
    3-Sulfinylpyruvic acid3-Sulfinopyruvate (see all 5)----
    3-Sulfopyruvic acid3-sulfopyruvate (see all 8)98022-26-5--
    4-Hydroxyphenylpyruvic acid(p-Hydroxyphenyl)pyruvate (see all 25)156-39-8--
    Cysteic acid2-Amino-3-sulfopropionate (see all 19)498-40-8--
    FamotidineAmfamox (see all 83)76824-35-6--
    L-Aspartic acid(+)-Aspartate (see all 41)56-84-8--
    L-Cysteine(+)-2-Amino-3-mercaptopropionic acid (see all 37)52-90-4--
    L-Glutamic acid(2S)-2-Aminopentanedioate (see all 49)56-86-0--

    4 DrugBank Compounds for GOT2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Aspartic Acid(+)-Aspartic acid (see all 23)56-84-8target--261660 823072 17139284 17016423 4404056 10592235
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--261660 17139284 17016423 10592235
    4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate-- --target--17139284 17016423 10592235
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor236311 17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GOT2 gene (2 alternative transcripts): 
    NM_001286220.1  NM_002080.3  

    Unigene Cluster for GOT2:

    Glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)
    Hs.599470  [show with all ESTs]
    Unigene Representative Sequence: NM_002080
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000245206(uc002eof.1 uc010vim.1) ENST00000434819 ENST00000494627
    ENST00000564400 ENST00000496461 ENST00000568368 ENST00000492378
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GOT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GOT2 (see all 27):
    hsa-miR-320a hsa-miR-30c hsa-miR-181c hsa-miR-4318 hsa-miR-139-5p hsa-miR-30d hsa-miR-30a hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidGOT2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GOT2
    Predesigned siRNA for gene silencing in human, mouse, rat GOT2
    Clone
    Products:
         
    OriGene clones in human, mouse for GOT2 (see all 8)
    OriGene ORF clones in mouse, rat for GOT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GOT2 (NM_002080)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GOT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GOT2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GOT2
    OriGene qSTAR qPCR primer pairs in human, mouse for GOT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GOT2
      QuantiTect SYBR Green Assays in human, mouse, rat GOT2
      QuantiFast Probe-based Assays in human, mouse, rat GOT2

    Additional mRNA sequence: 

    AK098313.1 AK223271.1 AK290847.1 AK295993.1 AK302249.1 AK307598.1 AL360255.1 BC000525.2 
    M22632.1 

    Selected DOTS entries (see all 29):

    DT.455985  DT.100876934  DT.100876949  DT.91936864  DT.95278326  DT.100876935  DT.97767200  DT.100876950 
    DT.120667140  DT.100876956  DT.100657705  DT.100876943  DT.120667221  DT.100876942  DT.100876958  DT.100876944 
    DT.100876952  DT.100876959  DT.120667118  DT.95278348  DT.100876957  DT.120667201  DT.40263483  DT.92464482 

    Selected AceView cDNA sequences (see all 954):

    BE727260 AL550931 BP338434 AA344106 BM708197 BQ774223 CB142860 BM670567 
    AA213451 AA324448 BQ226416 BU165987 BQ682215 CB997166 BM459311 BQ935540 
    AA340233 AA383616 BE645949 BQ892745 BU845756 BI833130 AW117977 F27259 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GOT2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
    SP1:                                                  -                             -                 -                 -         
    SP2:                                                  -                             -           -     -                           
    SP3:                                                  -                                                                           
    SP4:                                                  -                                                                           
    SP5:                    -     -                                                                                                   


    ECgene alternative splicing isoforms for GOT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    GOT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGACTTATT
    GOT2 Expression
    About this image


    GOT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Kidney (Urinary System)
             Metanephros
     
     Thymus (Hematopoietic System)
             Thymus
     
     Lower Urinary Tract (Urinary System)
             Ureter
    GOT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GOT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.599470
        Pathway & Disease-focused RT2 Profiler PCR Array including GOT2: 
              Amino Acid Metabolism I in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GOT2 gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Got21 , 5 glutamate oxaloacetate transaminase 2, mitochondrial1, 5 88.76(n)1
    94.65(a)1
      8 (47.79 cM)5
    147191  NM_010325.21  NP_034455.11 
     958641345 
    chicken
    (Gallus gallus)
    Aves GOT21 glutamic-oxaloacetic transaminase 2, mitochondrial more 78.15(n)
    85.04(a)
      396533  NM_205523.1  NP_990854.1 
    lizard
    (Anolis carolinensis)
    Reptilia GOT26
    glutamic-oxaloacetic transaminase 2, mitochondrial...
    85(a)
    1 ↔ 1
    GL343539.1(423522-438387)
    African clawed frog
    (Xenopus laevis)
    Amphibia got2-prov2 glutamate oxaloacetate transaminase 2 76.59(n)    BC056110.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb64g012 Danio rerio cDNA clone MGC66329 IMAGE5602691, complete more 76.77(n)    BC054684.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG42333
    Got21
    aspartate aminotransferase3
    Glutamate oxaloacetate transaminase 21
    63(a)
    (best of 2)3
    62.94(n)1
    63.11(a)1
      22B83
    333731  NM_164446.11  NP_722745.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C44E4.33
    got-2.21
    aminotransferase3
    got-2.21
    58(a)
    (best of 2)3
    64.15(n)1
    70.35(a)1
      I(4637394-4639062)3
    1808971  NM_171702.41  NP_741810.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AAT1(YKL106W)4 Mitochondrial aspartate aminotransferase, catalyzes more   --   11(237536-238891) 853755  NP_012816.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ASP11 ASP1 58.94(n)
    57.43(a)
      817648  NM_001124949.1  NP_001118421.1 
    rice
    (Oryza sativa)
    Liliopsida Os.47722 Oryza sativa (japonica cultivar-group) mRNA for aspartate more 74.31(n)    AK101008.1 


    ENSEMBL Gene Tree for GOT2 (if available)
    TreeFam Gene Tree for GOT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GOT2 gene
    GOT12  GOT1L12  
    3 SIMAP similar genes for GOT2 using alignment to 3 protein entries:     AATM_HUMAN (see all proteins):
    GOT1    GIG18    GOT1L1

    Find genes that share paralogs with GOT2           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for GOT2 (see all 7)
    PGOHUM00000239664 PGOHUM00000239689 PGOHUM00000244339 PGOHUM00000244732 PGOHUM00000241187


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GOT2 (see all 741)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1147844971,2
    F--58740537(+) CAGATC/GAACCA 1 -- ds50011Minor allele frequency- G:0.04WA 118
    rs1898406021,2
    --58740574(+) GAAAAA/GTGTAA 1 -- ds50010--------
    rs1504901041,2
    --58740576(+) AAAATA/GTAAGA 1 -- ds50010--------
    rs1831557441,2
    --58740608(+) CCTCAC/TAGCTC 1 -- ds50010--------
    rs1383257321,2
    C--58740634(+) TGCTCC/TTCAAT 1 -- ds50010--------
    rs1429975871,2
    C--58740704(+) ATTTAC/TGTTAC 1 -- ds50010--------
    rs1889552081,2
    --58740730(+) AGACCA/CCTGAA 1 -- ds50010--------
    rs1917929961,2
    --58740731(+) GACCAC/TTGAAG 1 -- ds50010--------
    rs1114715771,2
    C--58740746(+) CACTTCTC/-CTCCA 1 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs735492711,2
    C,F--58740772(+) TTGCCT/CATATC 1 -- ds50012Minor allele frequency- C:0.20WA 120

    HapMap Linkage Disequilibrium report for GOT2 (58741035 - 58768261 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for GOT2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1039184CNV Deletion17803354
    esv2714558CNV Deletion23290073
    nsv1817CNV Insertion18451855
    nsv509623CNV Insertion20534489
    nsv510686CNV Loss20534489
    nsv511049CNV Complex20534489
    dgv893e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138150    OMIM disorders: --

    4 diseases for GOT2:    
    About MalaCards
    reye syndrome    exanthem    gallbladder disease    fascioliasis

    Selected diseases from the University of Copenhagen DISEASES database for GOT2 (see all 25):
    Liver disease     Fatty liver disease     Hepatitis B     Vascular disease
    Hepatitis C     Cholestasis     Diabetes mellitus     Myocardial infarction
    Hepatocellular carcinoma     Thrombocytopenia     Cholangitis     Diarrhea
    Substance abuse     Hepatitis A     Kidney disease     Leukopenia
    Bilirubin metabolic disorder     Hypersensitivity reaction type II disease     Myopathy     Anemia

    Find genes that share disorders with GOT2           About GenesLikeMe

    Genetic Association Database (GAD): GOT2
    Human Genome Epidemiology (HuGE) Navigator: GOT2 (2 documents)

    Export disorders for GOT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GOT2 gene, integrated from 10 sources (see all 57):
    (articles sorted by number of sources associating them with GOT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study. (PubMed id 21223598)1, 4 Wineinger N.E....Tiwari H.K. (BMC Med Genomics 2011)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    4. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PubMed id 19305408)1, 4 Newton-Cheh C.... Stricker B.H. (Nat. Genet. 2009)
    5. Mitochondrial aspartate aminotransferase: a third kynurenate-producing enzyme in the mammalian brain. (PubMed id 17442055)1, 3 Guidetti P....Schwarcz R. (J. Neurochem. 2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Ethanol up-regulates fatty acid uptake and plasma membrane expression and export of mitochondrial aspartate aminotransferase in HepG2 cells. (PubMed id 9537447)1, 2 Zhou S.L.... Berk P.D. (Hepatology 1998)
    8. Nucleotide sequence and tissue distribution of the human mitochondrial aspartate aminotransferase mRNA. (PubMed id 3207426)1, 2 Pol S.... Barouki R. (Biochem. Biophys. Res. Commun. 1988)
    9. The primary structure of mitochondrial aspartate aminotransferase from human heart. (PubMed id 4052435)1, 2 Martini F.... Bossa F. (Biochim. Biophys. Acta 1985)
    10. Solution structure and backbone dynamics of human liver fatty acid binding protein: fatty acid binding revisited. (PubMed id 22713574)1 Cai J....Hamilton J.A. (Biophys. J. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2806 HGNC: 4433 AceView: GOT2 Ensembl:ENSG00000125166 euGenes: HUgn2806
    ECgene: GOT2 Kegg: 2806 H-InvDB: GOT2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GOT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GOT2 gene:
    Search GeneIP for patents involving GOT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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