Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GOT2 Gene

Aliases for GOT2 Gene

  • Glutamic-Oxaloacetic Transaminase 2 2 3 5
  • Kynurenine Aminotransferase IV 2 3 4
  • Plasma Membrane-Associated Fatty Acid-Binding Protein 3 4
  • Glutamic-Oxaloacetic Transaminase 2, Mitochondrial 2 3
  • Kynurenine--Oxoglutarate Transaminase IV 3 4
  • Kynurenine--Oxoglutarate Transaminase 4 3 4
  • Glutamate Oxaloacetate Transaminase 2 3 4
  • Kynurenine Aminotransferase 4 3 4
  • Aspartate Aminotransferase 2 2 3
  • Fatty Acid-Binding Protein 3 4
  • Aspartate Transaminase 2 2 3
  • Transaminase A 3 4
  • EC 2.6.1.1 4 61
  • FABP-1 3 4
  • FABPpm 3 4
  • MAspAT 3 4
  • Glutamic-Oxaloacetic Transaminase 2, Mitochondrial (Aspartate Aminotransferase 2) 2
  • Aspartate Aminotransferase, Mitochondrial 3
  • EC 2.6.1.7 4
  • EC 2.6.1 61
  • MitAAT 3
  • KATIV 3
  • KYAT4 3
  • KAT4 3

External Ids for GOT2 Gene

Previous GeneCards Identifiers for GOT2 Gene

  • GC16M049137
  • GC16M058827
  • GC16M058475
  • GC16M058516
  • GC16M057298
  • GC16M058741
  • GC16M044606

Summaries for GOT2 Gene

Entrez Gene Summary for GOT2 Gene

  • Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

GeneCards Summary for GOT2 Gene

GOT2 (Glutamic-Oxaloacetic Transaminase 2) is a Protein Coding gene. Diseases associated with GOT2 include Coenurosis and Acute Vascular Insufficiency Of Intestine. Among its related pathways are Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism and Metabolism. GO annotations related to this gene include poly(A) RNA binding and kynurenine-oxoglutarate transaminase activity. An important paralog of this gene is GOT1.

UniProtKB/Swiss-Prot for GOT2 Gene

  • Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.

Gene Wiki entry for GOT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOT2 Gene

Genomics for GOT2 Gene

Regulatory Elements for GOT2 Gene

Enhancers for GOT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F058731 0.4 ENCODE 22.6 +0.9 914 3.3 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 GOT2 SLC38A7 ENSG00000245768 GC16M058732
GH16F058755 1 Ensembl ENCODE 22 -22.0 -22002 1.6 ELF3 ARID4B ZNF2 RAD21 ZNF143 DEK THAP11 ZNF654 MXD4 CEBPB GOT2 SLC38A7 GC16M058744 RN7SL143P RNU6-1155P
GH16F058654 0.7 ENCODE 16 +79.3 79299 1.4 SOX13 ARID4B ZNF175 CEBPG DNMT3B POLR2A GATAD2A NFIA L3MBTL2 TGIF2 GOT2 GINS3 CNOT1 SLC38A7
GH16F058699 0.2 Ensembl 11.6 +35.1 35057 0.2 GATAD2A PKNOX1 L3MBTL2 CEBPB CEBPG ZNF335 NFIL3 TFDP1 IKZF1 CEBPA GOT2 SLC38A7 ENSG00000279889
GH16F058683 1.1 ENCODE 11.4 +49.8 49821 1.7 PKNOX1 ATF1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A ZNF48 ETS1 GLIS2 CNOT1 GOT2 ENSG00000245768 RNU6-1155P SLC38A7
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GOT2 on UCSC Golden Path with GeneCards custom track

Promoters for GOT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001505588 457 1801 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5

Genomic Location for GOT2 Gene

Chromosome:
16
Start:
58,707,131 bp from pter
End:
58,734,357 bp from pter
Size:
27,227 bases
Orientation:
Minus strand

Genomic View for GOT2 Gene

Genes around GOT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOT2 Gene

Proteins for GOT2 Gene

  • Protein details for GOT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00505-AATM_HUMAN
    Recommended name:
    Aspartate aminotransferase, mitochondrial
    Protein Accession:
    P00505
    Secondary Accessions:
    • B4DJA6
    • E7ERW2
    • Q53FL3
    • Q9BWA3

    Protein attributes for GOT2 Gene

    Size:
    430 amino acids
    Molecular mass:
    47518 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

    Three dimensional structures from OCA and Proteopedia for GOT2 Gene

    Alternative splice isoforms for GOT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOT2 Gene

Post-translational modifications for GOT2 Gene

  • Ubiquitination at Lys 396
  • Modification sites at PhosphoSitePlus

Other Protein References for GOT2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for GOT2

Domains & Families for GOT2 Gene

Graphical View of Domain Structure for InterPro Entry

P00505

UniProtKB/Swiss-Prot:

AATM_HUMAN :
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Family:
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
genes like me logo Genes that share domains with GOT2: view

No data available for Gene Families for GOT2 Gene

Function for GOT2 Gene

Molecular function for GOT2 Gene

GENATLAS Biochemistry:
glutamic-oxaloacetic transaminase 2,mitochondrial (aspartate aminotransferase 1)
UniProtKB/Swiss-Prot CatalyticActivity:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
UniProtKB/Swiss-Prot CatalyticActivity:
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
UniProtKB/Swiss-Prot Function:
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.
UniProtKB/Swiss-Prot Induction:
Up-regulated by long-time exposure to alcohol.

Enzyme Numbers (IUBMB) for GOT2 Gene

Gene Ontology (GO) - Molecular Function for GOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity ISS --
GO:0005543 phospholipid binding IEA --
GO:0008483 transaminase activity IEA --
GO:0016212 kynurenine-oxoglutarate transaminase activity IEA --
GO:0016597 amino acid binding IEA --
genes like me logo Genes that share ontologies with GOT2: view
genes like me logo Genes that share phenotypes with GOT2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOT2 Gene

Localization for GOT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOT2 Gene

Mitochondrion matrix. Cell membrane. Note=Exposure to alcohol promotes translocation to the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GOT2 Gene COMPARTMENTS Subcellular localization image for GOT2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
plasma membrane 5
cytosol 3
peroxisome 3
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
nucleus 2
vacuole 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for GOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005759 mitochondrial matrix IEA,TAS --
GO:0005886 plasma membrane IEA,IDA 9537447
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with GOT2: view

Pathways & Interactions for GOT2 Gene

genes like me logo Genes that share pathways with GOT2: view

Gene Ontology (GO) - Biological Process for GOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006094 gluconeogenesis TAS --
GO:0006103 2-oxoglutarate metabolic process ISS --
GO:0006107 oxaloacetate metabolic process IEA --
GO:0006520 cellular amino acid metabolic process IEA --
GO:0006531 aspartate metabolic process ISS --
genes like me logo Genes that share ontologies with GOT2: view

No data available for SIGNOR curated interactions for GOT2 Gene

Drugs & Compounds for GOT2 Gene

(11) Drugs for GOT2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Aspartic acid Approved Nutra Target 0
Famotidine Approved Pharma Histamine H2-receptor antagonist 59
L-Cysteine Approved Nutra 0
L-Phenylalanine Approved Nutra 0
L-Tyrosine Approved Nutra 0

(12) Additional Compounds for GOT2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Mercaptopyruvic acid
  • 3-Mercapto-pyruvate
  • 3-Mercapto-pyruvic acid
  • 3-Mercaptopyruvate
  • 3-Mercaptopyruvic acid
  • beta-3-Mercapto-2-oxo-propanoate
2464-23-5
3-Sulfinylpyruvic acid
  • 3-Sulfinopyruvate
  • 3-Sulfinyl-pyruvate
  • 3-Sulfinylpyruvate
  • 3-Sulphinyl-pyruvate
  • beta-Sulfinylpyruvate
4-(2-Aminophenyl)-2,4-dioxobutanoic acid
  • 4-(2-Aminophenyl)-2,4-dioxo-butanoate
  • 4-(2-Aminophenyl)-2,4-dioxo-butanoic acid
  • 4-(2-Aminophenyl)-2,4-dioxobutanoate
  • 4-(2-Aminophenyl)-2,4-dioxobutanoic acid
4-Hydroxy-L-glutamic acid
  • (2S)-2-amino-4-hydroxypentanedioate
  • (2S)-2-amino-4-hydroxypentanedioic acid
  • 4-Hydroxy-L-glutamate
  • 4-Hydroxy-L-glutamic acid
  • Erythro-4-hydroxyglutamate
2485-33-8
4-Hydroxyphenylpyruvic acid
  • (p-hydroxyphenyl)-Pyruvate
  • (p-hydroxyphenyl)-Pyruvic acid
  • (p-Hydroxyphenyl)pyruvate
  • (p-Hydroxyphenyl)pyruvic acid
  • 3-(4-Hydroxyphenyl)-2-oxo-propanoate
156-39-8
genes like me logo Genes that share compounds with GOT2: view

Transcripts for GOT2 Gene

Unigene Clusters for GOT2 Gene

Glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOT2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - - - -
SP2: - - - -
SP3: -
SP4: -
SP5: - -
SP6: - - -
SP7:

Relevant External Links for GOT2 Gene

GeneLoc Exon Structure for
GOT2
ECgene alternative splicing isoforms for
GOT2

Expression for GOT2 Gene

mRNA expression in normal human tissues for GOT2 Gene

mRNA differential expression in normal tissues according to GTEx for GOT2 Gene

This gene is overexpressed in Heart - Left Ventricle (x6.1) and Muscle - Skeletal (x5.5).

Protein differential expression in normal tissues from HIPED for GOT2 Gene

This gene is overexpressed in Liver, secretome (20.2) and Heart (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GOT2 Gene



Protein tissue co-expression partners for GOT2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GOT2 Gene:

GOT2

SOURCE GeneReport for Unigene cluster for GOT2 Gene:

Hs.599470
genes like me logo Genes that share expression patterns with GOT2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GOT2 Gene

Orthologs for GOT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GOT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOT2 34 35
  • 99.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GOT2 35
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GOT2 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GOT2 34
  • 90.78 (n)
-- 35
  • 84 (a)
OneToMany
cow
(Bos Taurus)
Mammalia GOT2 34 35
  • 90 (n)
mouse
(Mus musculus)
Mammalia Got2 34 16 35
  • 88.76 (n)
rat
(Rattus norvegicus)
Mammalia Got2 34
  • 88.29 (n)
chicken
(Gallus gallus)
Aves GOT2 34 35
  • 78.15 (n)
lizard
(Anolis carolinensis)
Reptilia GOT2 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia got2 34
  • 72.68 (n)
Str.1247 34
African clawed frog
(Xenopus laevis)
Amphibia got2-prov 34
zebrafish
(Danio rerio)
Actinopterygii got2b 35
  • 77 (a)
OneToMany
got2a 34 35
  • 72.35 (n)
wufb64g01 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9809 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009685 34
  • 64.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4233 36
  • 63 (a)
Got2 34 35
  • 62.94 (n)
CG8430 36
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea got-2.2 34 35
  • 64.15 (n)
got-2.1 35
  • 61 (a)
OneToMany
C44E4.3 36
  • 58 (a)
T01C8.4 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAT2 35
  • 43 (a)
OneToMany
AAT1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons ASP1 34
  • 58.94 (n)
soybean
(Glycine max)
eudicotyledons Gma.1611 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3126 34
rice
(Oryza sativa)
Liliopsida Os02g0236000 34
  • 58.04 (n)
Os.4772 34
barley
(Hordeum vulgare)
Liliopsida Hv.7187 34
wheat
(Triticum aestivum)
Liliopsida Ta.5314 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 65 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU08411 34
  • 61.05 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC725.01 34
  • 58.14 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14130 34
Species where no ortholog for GOT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for GOT2 Gene

ENSEMBL:
Gene Tree for GOT2 (if available)
TreeFam:
Gene Tree for GOT2 (if available)

Paralogs for GOT2 Gene

Paralogs for GOT2 Gene

(3) SIMAP similar genes for GOT2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GOT2: view

Variants for GOT2 Gene

Sequence variations from dbSNP and Humsavar for GOT2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10500407 -- 58,719,857(+) TCAAA(A/G)TTCCT intron-variant
rs10563758 -- 58,734,715(+) TTTTT(-/T)GAGAT upstream-variant-2KB
rs1058192 -- 58,716,700(-) GTTTG(C/T)CTCTG reference, synonymous-codon
rs10676089 -- 58,712,548(+) AACAA(-/CAA)GAACA intron-variant
rs11076256 -- 58,718,562(-) CTTGC(A/G)GTTTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GOT2 Gene

Variant ID Type Subtype PubMed ID
esv1039184 CNV deletion 17803354
esv2714558 CNV deletion 23290073
esv2758650 CNV loss 17122850
nsv1065296 CNV loss 25217958
nsv1817 CNV insertion 18451855
nsv509623 CNV insertion 20534489
nsv510686 CNV deletion 20534489
nsv511049 OTHER complex 20534489
nsv954067 CNV deletion 24416366
nsv984340 CNV duplication 23825009

Variation tolerance for GOT2 Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.08; 75.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GOT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOT2 Gene

Disorders for GOT2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for GOT2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
coenurosis
  • coenuriasis
acute vascular insufficiency of intestine
  • acute gastrointestinal tract vascular insuffic.
histidinemia
  • histidinuria
histidine metabolism disease
  • disturbances of histidine metabolism
pleomorphic lipoma
  • lipoma
- elite association - COSMIC cancer census association via MalaCards
Search GOT2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GOT2

Genetic Association Database (GAD)
GOT2
Human Genome Epidemiology (HuGE) Navigator
GOT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GOT2
genes like me logo Genes that share disorders with GOT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GOT2 Gene

Publications for GOT2 Gene

  1. Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study. (PMID: 21223598) Wineinger N.E. … Tiwari H.K. (BMC Med Genomics 2011) 3 46 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PMID: 19305408) Newton-Cheh C. … Stricker B.H. (Nat. Genet. 2009) 3 46 64
  4. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler H.E. … Kim S.K. (PLoS Genet. 2009) 3 46 64
  5. Mitochondrial aspartate aminotransferase: a third kynurenate-producing enzyme in the mammalian brain. (PMID: 17442055) Guidetti P. … Schwarcz R. (J. Neurochem. 2007) 2 3 64

Products for GOT2 Gene

Sources for GOT2 Gene

Content
Loading form....