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GOT1 Gene

protein-coding   GIFtS: 66
GCID: GC10M101146

Glutamic-Oxaloacetic Transaminase 1, Soluble

(Previous names: glutamic-oxaloacetic transaminase 1, soluble (aspartate...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutamic-Oxaloacetic Transaminase 1, Soluble1 2     cCAT2 3
Aspartate Aminotransferase 11 2     EC 2.6.1.13 8
Aspartate Transaminase 11 2     ASTQTL12 5
Cysteine Aminotransferase, Cytoplasmic2 3     Glutamic-Oxaloacetic Transaminase 1, Soluble (Aspartate Aminotransferase
1)1
Cysteine Transaminase, Cytoplasmic2 3     GIG182
Glutamate Oxaloacetate Transaminase 12 3     Aspartate Aminotransferase, Cytoplasmic2
Transaminase A2 3     Growth-Inhibiting Protein 182
cAspAT2 3     EC 2.6.1.33

External Ids:    HGNC: 44321   Entrez Gene: 28052   Ensembl: ENSG000001200537   OMIM: 1381805   UniProtKB: P171743   

Export aliases for GOT1 gene to outside databases

Previous GC identifers: GC10M100049 GC10M100390 GC10M101287 GC10M100821 GC10M094783


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GOT1 Gene:
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and
mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and
tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. (provided by RefSeq, Jul
2008)

GeneCards Summary for GOT1 Gene:
GOT1 (glutamic-oxaloacetic transaminase 1, soluble) is a protein-coding gene. Diseases associated with GOT1 include aspartate aminotransferase, serum level of, qtl1, and exanthem. GO annotations related to this gene include pyridoxal phosphate binding and carboxylic acid binding. An important paralog of this gene is GOT2.

UniProtKB/Swiss-Prot: AATC_HUMAN, P17174
Function: Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate,
the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate
in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during
development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of
mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the
action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and
neuroprotectant in the brain

Gene Wiki entry for GOT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the GOT1 gene promoter:
         STAT1   STAT1beta   Egr-4   STAT1alpha   AREB6   Egr-2   PPAR-gamma1   FOXO1a   PPAR-gamma2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGOT1 promoter sequence
   Search Chromatin IP Primers for GOT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GOT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.1-q25.1   Ensembl cytogenetic band:  10q24.2   HGNC cytogenetic band: 10q24.1-q25.1

GOT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GOT1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M101146:  view genomic region     (about GC identifiers)

Start:
101,156,627 bp from pter      End:
101,190,530 bp from pter
Size:
33,904 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AATC_HUMAN, P17174 (See protein sequence)
Recommended Name: Aspartate aminotransferase, cytoplasmic  
Size: 413 amino acids; 46248 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer
Miscellaneous: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes
Miscellaneous: Aspartate aminotransferase activity found to be increased in cerebral spinal fluid (CSF) of
patients with Alzheimer disease (PubMed:16039064). Fetal serum levels of the enzyme in the umbilical artery and
vein are found to be significantly higher than maternal serum levels (PubMed:22633534)
1 PDB 3D structure from and Proteopedia for GOT1:
3II0 (3D)    
Secondary accessions: B2R6R7 Q5VW80

Explore the universe of human proteins at neXtProt for GOT1: NX_P17174

Explore proteomics data for GOT1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GOT1 (P17174) (see all 21)
     DPTPEQW  EKRVGGV  CAHNPTG  AGFKDIR 


    See GOT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002070.1  
    ENSEMBL proteins: 
     ENSP00000359539   ENSP00000445578  
    Reactome Protein details: P17174

    GOT1 Human Recombinant Protein Products:

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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for GOT1
    OriGene Protein Over-expression Lysate for GOT1
    OriGene MassSpec for GOT1
    OriGene Custom Protein Services for GOT1
    GenScript Custom Purified and Recombinant Proteins Services for GOT1
    Novus Biologicals GOT1 Proteins
    Novus Biologicals GOT1 Lysates
    Sino Biological Recombinant Protein for GOT1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GOT1
    Browse Proteins at Cloud-Clone Corp.

    GOT1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals GOT1 Antibodies
    Abcam antibodies for GOT1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for GOT1
    LSBio Antibodies in human, mouse, rat for GOT1

    GOT1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GOT1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR004838 NHTrfase_class1_PyrdxlP-BS
     IPR004839 Aminotransferase_I/II
     IPR015424 PyrdxlP-dep_Trfase
     IPR000796 Asp_trans
     IPR015421 PyrdxlP-dep_Trfase_major_sub1

    Graphical View of Domain Structure for InterPro Entry P17174

    ProtoNet protein and cluster: P17174

    3 Blocks protein domains:
    IPB000796 Aspartate aminotransferase signature
    IPB004838 Aminotransferase
    IPB004839 Aminotransferase


    UniProtKB/Swiss-Prot: AATC_HUMAN, P17174
    Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family


    GOT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AATC_HUMAN, P17174
    Function: Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate,
    the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate
    in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during
    development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of
    mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the
    action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and
    neuroprotectant in the brain
    Catalytic activity: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate
    Catalytic activity: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate

         Genatlas biochemistry entry for GOT1:
    glutamic-oxaloacetic transaminase 1,soluble (aspartate aminotransferase 1)

         Enzyme Numbers (IUBMB): EC 2.6.1.11 2 EC 2.6.1.31

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004069L-aspartate:2-oxoglutarate aminotransferase activity TAS--
    GO:0004609phosphatidylserine decarboxylase activity IEA--
    GO:0008483transaminase activity TAS--
    GO:0030170pyridoxal phosphate binding IEA--
    GO:0031406carboxylic acid binding IEA--
         
    GOT1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for GOT1:
     Elongated cells  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GOT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GOT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GOT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GOT1

    miRNA
    Products:
        
    miRTarBase miRNAs that target GOT1:
    hsa-mir-769-5p (MIRT039193)

    Block miRNA regulation of human, mouse, rat GOT1 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate GOT1:
    hsa-miR-876-3p hsa-miR-9 hsa-miR-3122 hsa-miR-1276 hsa-miR-3913-5p hsa-miR-3151 hsa-miR-323-5p hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmidGOT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GOT1
    Predesigned siRNA for gene silencing in human, mouse, rat GOT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GOT1

    Clone
    Products:
         
    OriGene clones in human, mouse for GOT1 (see all 7)
    OriGene ORF clones in mouse, rat for GOT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GOT1 (NM_002079)
    Sino Biological Human cDNA Clone for GOT1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GOT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GOT1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GOT1
    Browse ESI BIO Cell Lines and PureStem Progenitors for GOT1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AATC_HUMAN, P17174: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular3
    mitochondrion3
    lysosome2
    nucleus2
    peroxisome2
    plasma membrane2
    vacuole2
    cytoskeleton1
    endoplasmic reticulum1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA7060339
    GO:0005764lysosome IEA--
    GO:0005829cytosol TAS--
    GO:0043679axon terminus IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    GOT1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GOT1 About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Phenylalanine metabolism
    Phenylalanine metabolism0.36
    Phenylalanine, tyrosine and tryptophan biosynthesis0.00
    Tyrosine metabolism0.36
    phenylalanine degradation IV0.00
    phenylalanine utilization0.33
    2Glucose metabolism
    Glucose metabolism0.44
    malate-aspartate shuttle0.00
    Gluconeogenesis0.44
    3Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    4Sulfur amino acid metabolism
    Sulfur amino acid metabolism0.35
    Cysteine and methionine metabolism0.35
    5Valproic Acid Pathway, Pharmacodynamics
    aspartate biosynthesis0.00
    Valproic Acid Pathway, Pharmacodynamics

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected BioSystems Pathways for GOT1 (see all 9)
        Trans-sulfuration pathway
    malate-aspartate shuttle
    Alanine and aspartate metabolism
    Glycolysis and Gluconeogenesis
    phenylalanine degradation IV


    3 Reactome Pathways for GOT1
        Gluconeogenesis
    Methionine salvage pathway
    Amino acid synthesis and interconversion (transamination)

    1 PharmGKB Pathway for GOT1
        Valproic Acid Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for GOT1) (see all 10):
        Alanine, aspartate and glutamate metabolism
    Cysteine and methionine metabolism
    Arginine and proline metabolism
    Tyrosine metabolism
    Phenylalanine metabolism


    GOT1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including GOT1: 
              Amino Acid Metabolism II in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GOT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GOT1 (P171742, 3 ENSP000003595394) via UniProtKB, MINT, STRING, and/or I2D (see all 237)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000096sulfur amino acid metabolic process TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006006glucose metabolic process TAS--
    GO:0006094gluconeogenesis TAS--
    GO:00061032-oxoglutarate metabolic process ISS--

    GOT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GOT1 (AATC)

    Selected HMDB Compounds for GOT1 (see all 18)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Mercaptopyruvic acid3-Mercaptopyruvate (see all 13)2464-23-5--
    3-Sulfinoalanine3-Sulphino-L-alanine (see all 9)1115-65-7--
    3-Sulfinylpyruvic acid3-Sulfinopyruvate (see all 5)----
    3-Sulfopyruvic acid3-sulfopyruvate (see all 8)98022-26-5--
    4-Hydroxy-2-oxoglutaric acid(+/-)-2-hydroxy-4-oxopentanedioate (see all 9)1187-99-1--
    4-Hydroxy-L-glutamic acid4-hydroxy-L-glutamate (see all 7)2485-33-8--
    4-Hydroxyphenylpyruvic acid(p-Hydroxyphenyl)pyruvate (see all 25)156-39-8--
    Cysteic acid2-Amino-3-sulfopropionate (see all 19)498-40-8--
    FamotidineAmfamox (see all 83)76824-35-6--
    L-Aspartic acid(+)-Aspartate (see all 41)56-84-8--

    5 DrugBank Compounds for GOT1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Aspartic Acid(+)-Aspartic acid (see all 23)56-84-8target--17244260 17328883 17168267 17442055 17545671
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetactivator12167474 11752352 16925884 11340119 11888303
    L-Cysteine(R)-2-Amino-3-mercaptopropanoic acid (see all 13)52-90-4target--17139284 17016423
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--17444813
    Maleic Acid-- 110-16-7target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GOT1 gene: 
    NM_002079.2  

    Unigene Cluster for GOT1:

    Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
    Hs.500756  [show with all ESTs]
    Unigene Representative Sequence: NM_002079
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370508(uc001kpr.3 uc009xwi.2) ENST00000489349 ENST00000471741
    ENST00000543866
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GOT1 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate GOT1:
    hsa-miR-876-3p hsa-miR-9 hsa-miR-3122 hsa-miR-1276 hsa-miR-3913-5p hsa-miR-3151 hsa-miR-323-5p hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmidGOT1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GOT1
    Predesigned siRNA for gene silencing in human, mouse, rat GOT1
    Clone
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    OriGene clones in human, mouse for GOT1 (see all 7)
    OriGene ORF clones in mouse, rat for GOT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GOT1 (NM_002079)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GOT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GOT1
    Primer
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    OriGene qPCR primer pairs and template standards for GOT1
    OriGene qSTAR qPCR primer pairs in human, mouse for GOT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GOT1
      QuantiTect SYBR Green Assays in human, mouse, rat GOT1
      QuantiFast Probe-based Assays in human, mouse, rat GOT1

    Additional mRNA sequence: 

    AF052153.1 AK293483.1 AK301916.1 AK309174.1 AK312684.1 AY513279.1 BC000498.2 M37400.1 

    18 DOTS entries:

    DT.95161440  DT.100880095  DT.450537  DT.100767584  DT.100880100  DT.121276203  DT.95161437  DT.100880101 
    DT.91766831  DT.91766816  DT.102823882  DT.121276217  DT.86843273  DT.91766828  DT.95161431  DT.97854688 
    DT.100743022  DT.101979725 

    Selected AceView cDNA sequences (see all 584):

    R38726 BU557951 H98877 BM477387 AV651308 BQ574228 BM980073 F02675 
    CR625110 CR606661 CR621846 BQ427619 AW409837 AI365638 BU848920 BI833571 
    CR598904 BU615309 W87692 F10117 AW135113 AF052153 CR615083 BI912612 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GOT1 expression in normal human tissues (normalized intensities)      GOT1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACGGACACG
    GOT1 Expression
    About this image


    GOT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
    GOT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GOT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.500756
        Pathway & Disease-focused RT2 Profiler PCR Array including GOT1: 
              Amino Acid Metabolism II in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GOT1
    OriGene qSTAR qPCR primer pairs in human, mouse for GOT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GOT1
    QuantiTect SYBR Green Assays in human, mouse, rat GOT1
    QuantiFast Probe-based Assays in human, mouse, rat GOT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GOT1 gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Got11 , 5 glutamate oxaloacetate transaminase 1, soluble1, 5 87.09(n)1
    90.8(a)1
      19 (36.67 cM)5
    147181  NM_010324.21  NP_034454.21 
     434997525 
    chicken
    (Gallus gallus)
    Aves GOT11 glutamic-oxaloacetic transaminase 1, soluble (aspartate more 76.12(n)
    80.44(a)
      396261  NM_205321.1  NP_990652.1 
    lizard
    (Anolis carolinensis)
    Reptilia GOT16
    glutamic-oxaloacetic transaminase 1, soluble
    81(a)
    1 ↔ 1
    3(38473516-38490723)
    African clawed frog
    (Xenopus laevis)
    Amphibia xr406-prov2 Aspartate aminotransferase 75.29(n)    BC045269.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.282362 Danio rerio cDNA clone MGC55996 IMAGE3819704, complete more 75.9(n)    BC047800.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG84303
    Got11
    aspartate aminotransferase3
    Glutamate oxaloacetate transaminase 11
    56(a)3
    59.27(n)1
    57.11(a)1
      367821  NM_166148.11  NP_725534.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T01C8.53
    got-1.21
    aminotransferase3
    got-1.21
    53(a)
    (best of 3)3
    58.5(n)1
    54.46(a)1
      X(16822325-16823912)3
    1817261  NM_078308.51  NP_510709.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AAT2(YLR027C)4
    AAT21
    Cytosolic aspartate aminotransferase, involved in nitrogen more4
    AAT21
    51.8(n)1
    48.12(a)1
      12(198085-196829)4
    8507141, 4  NP_013127.21, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ASP31 ASP3 55.61(n)
    50.62(a)
      831024  NM_121190.2  NP_196713.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g07606001 Os01g0760600 55.94(n)
    51.35(a)
      4325621  NM_001050852.1  NP_001044317.1 


    ENSEMBL Gene Tree for GOT1 (if available)
    TreeFam Gene Tree for GOT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GOT1 gene
    GOT22  GOT1L12  
    3 SIMAP similar genes for GOT1 using alignment to 2 protein entries:     AATC_HUMAN (see all proteins):
    GIG18    GOT2    GOT1L1

    GOT1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GOT1
    PGOHUM00000249433


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    AATC_HUMAN, P17174: Genetic variations in GOT1 are associated with low serum aspartate aminotransferase and define the
    aspartate aminotransferase serum level quantitative trait locus 1 (ASTQTL1) [MIM:614419]


    Selected SNPs for GOT1 (see all 646)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1996898091,2
    C--101158427(+) AAAAA-/AGAATT 1 -- int10--------
    rs57873361,2
    C--101166940(+) CATTAGT/-GTGTG 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs106688921,2
    C--101167543(+) TATTTATTT/-  
            
    TACTT
    1 -- int11Minor allele frequency- -:0.00NA 2
    rs672708821,2
    C--101177817(+) AAAAAT/AATATA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs113947461,2
    C--101178251(+) TTTTT-/T/TT  
            
    CTTTT
    1 -- int1 trp31NA 2
    rs1494229631,2
    --101518023(+) GAATTA/GACTTT 1 -- ds50010--------
    rs1162763971,2
    C,F--101518056(+) ATAGAC/TCTCTT 1 -- ds50011Minor allele frequency- T:0.05WA 118
    rs1154516831,2
    C,F--101518071(+) TAAGTA/GACATC 1 -- ds50011Minor allele frequency- G:0.01WA 118
    rs1915767661,2
    --101518114(+) GGAGCA/GGCCCT 1 -- ds50010--------
    rs122175841,2
    F,A,H--101518204(+) CTGATG/TTTCTA 1 -- ds50014Minor allele frequency- T:0.01NS EA 414

    HapMap Linkage Disequilibrium report for GOT1 (101156627 - 101190530 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GOT1: --
    Human Gene Mutation Database (HGMD): GOT1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GOT1
    DNA2.0 Custom Variant and Variant Library Synthesis for GOT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 138180   
    OMIM disorders: 614419  
    Selected diseases for GOT1 (see all 45):    About MalaCards
    aspartate aminotransferase, serum level of, qtl1    exanthem    gallbladder disease    acute pyelonephritis
    bilirubin metabolic disorder    pyelonephritis    reye syndrome    substance abuse
    severe acute respiratory syndrome    leukopenia    osteopetrosis    glucose intolerance
    hepatitis a    autoimmune hepatitis    periodontal disease    primary biliary cirrhosis
    cholangitis    brain disease    diarrhea    periodontitis

    Selected diseases from the University of Copenhagen DISEASES database for GOT1 (see all 24):
    Liver disease     Fatty liver disease     Hepatitis B     Hepatitis C
    Cholestasis     Vascular disease     Thrombocytopenia     Hepatocellular carcinoma
    Autoimmune hepatitis     Cholangitis     Diarrhea     Myocardial infarction
    Substance abuse     Hepatitis A     Leukopenia     Diabetes mellitus
    Bilirubin metabolic disorder     Anemia     Myopathy     Exanthem

    GOT1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GOT1
    Human Genome Epidemiology (HuGE) Navigator: GOT1 (3 documents)

    Export disorders for GOT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GOT1 gene, integrated from 10 sources (see all 82):
    (articles sorted by number of sources associating them with GOT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Properties of human liver cytosolic aspartate aminotransferase mRNAs generated by alternative polyadenylation site selection. (PubMed id 1974457)1, 2, 3 Bousquet-Lemercier B.... Barouki R. (Biochemistry 1990)
    2. Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels. (PubMed id 21900944)1, 2 Shen H.... Gong D.W. (J. Hum. Genet. 2011)
    3. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The amino acid sequence of cytosolic aspartate aminotransferase from human liver. (PubMed id 2241899)1, 2 Doyle J.M.... Doonan S. (Biochem. J. 1990)
    7. Genetic homogeneity, high-resolution mapping, and mutation analysis of the urofacial (Ochoa) syndrome and exclusion of the glutamate oxaloacetate transaminase gene (GOT1) in the critical region as the disease gene. (PubMed id 10360399)1, 9 Wang C.Y....She J.X. (Am. J. Med. Genet. 1999)
    8. Genome-wide association study of liver enzymes in korean children. (PubMed id 24124411)1 Park T.J....Lee J.Y. (amp 2013)
    9. Independent and supra-additive effects of alcohol consumption, cigarette smoking, and metabolic syndrome on the elevation of serum liver enzyme levels. (PubMed id 23667618)1 Park E.Y....Shin H.R. (PLoS ONE 2013)
    10. Elevated aspartate and alanine aminotransferase levels and natural death among patients with methamphetamine dependence. (PubMed id 22242166)1 Kuo C.J....Chen W.J. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2805 HGNC: 4432 AceView: GOT1 Ensembl:ENSG00000120053 euGenes: HUgn2805
    ECgene: GOT1 Kegg: 2805 H-InvDB: GOT1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GOT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GOT1 gene:
    Search GeneIP for patents involving GOT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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