Aliases for GOT1 Gene
Aliases for GOT1 Gene
- Glutamic-Oxaloacetic Transaminase 1 2 3 5
- Glutamate Oxaloacetate Transaminase 1 2 3 4
- Glutamic-Oxaloacetic Transaminase 1, Soluble 2 3
- Cysteine Aminotransferase, Cytoplasmic 3 4
- Cysteine Transaminase, Cytoplasmic 3 4
- Aspartate Aminotransferase 1 2 3
- Aspartate Transaminase 1 2 3
- Transaminase A 3 4
- EC 2.6.1.1 4 56
- CAspAT 3 4
External Ids for GOT1 Gene
- HGNC: 4432
- Entrez Gene: 2805
- Ensembl: ENSG00000120053
- OMIM: 138180
- UniProtKB: P17174
Previous GeneCards Identifiers for GOT1 Gene
- GC10M100049
- GC10M100390
- GC10M101287
- GC10M100821
- GC10M101146
- GC10M094783
Summaries for GOT1 Gene
-
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]
GeneCards Summary for GOT1 Gene
GOT1 (Glutamic-Oxaloacetic Transaminase 1) is a Protein Coding gene. Diseases associated with GOT1 include Aspartate Aminotransferase, Serum Level Of, Quantitative Trait Locus 1 and Cholesterol Ester Storage Disease. Among its related pathways are Glycosaminoglycan metabolism and Phenylalanine metabolism. Gene Ontology (GO) annotations related to this gene include pyridoxal phosphate binding and carboxylic acid binding. An important paralog of this gene is GOT2.
UniProtKB/Swiss-Prot for GOT1 Gene
-
Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
Additional gene information for GOT1 Gene
- Monarch Initiative
- Search for GOT1 at DataMed
- Search for GOT1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOT1 Gene
Genomics for GOT1 Gene
GeneHancer (GH) Regulatory Elements for GOT1 Gene
- Top Transcription factor binding sites by QIAGEN in the GOT1 gene promoter:
Regulatory Element Products
Genomic Locations for GOT1 Gene
- chr10:99,396,870-99,430,773
- (GRCh38/hg38)
- Size:
- 33,904 bases
- Orientation:
- Minus strand
- chr10:101,156,627-101,190,530
- (GRCh37/hg19)
Genomic View for GOT1 Gene
- Cytogenetic band:
-
- 10q24.2 by Ensembl
- 10q24.2 by Entrez Gene
- 10q24.2 by HGNC


RefSeq DNA sequence for GOT1 Gene
Proteins for GOT1 Gene
-
Protein details for GOT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P17174-AATC_HUMAN
- Recommended name:
- Aspartate aminotransferase, cytoplasmic
- Protein Accession:
- P17174
- B2R6R7
- B7Z7E9
- Q5VW80
Protein attributes for GOT1 Gene
- Size:
- 413 amino acids
- Molecular mass:
- 46248 Da
- Cofactor:
- Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
- Quaternary structure:
-
- Homodimer.
- Miscellaneous:
-
- Aspartate aminotransferase activity found to be increased in cerebral spinal fluid (CSF) of patients with Alzheimer disease (PubMed:16039064). Fetal serum levels of the enzyme in the umbilical artery and vein are found to be significantly higher than maternal serum levels (PubMed:22633534).
- In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
Protein Expression for GOT1 Gene
Selected DME Specific Peptides for GOT1 Gene
- P17174:
-
- SKNFGLYNERVG
- TWSNPPAQGARIVA
- KHIYLLPSGRIN
- HNPTGIDPT
- AYQGFASG
- HITDQIGMF
- DAWAIRYFV
- DPTPEQW
- GMFSFTGL
- GTGALRIGA
- CASRLALGDDSPAL
- NHEYLPILGLAEFR
- DLENAPEFSI
- TLSNPELF
- NVKTMADR
- EKRVGGV
- KVEQKIAN
- NLGVGAYR
- YVSSPTWENHN
- AGFKDIR
- CAHNPTG
Post-translational modifications for GOT1 Gene
Other Protein References for GOT1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for GOT1
- Novus Biologicals Antibodies for GOT1
-
Abcam antibodies for GOT1
-
Cloud-Clone Corp. Antibodies for GOT1
- Invitrogen Antibodies for GOT1
- Search GeneTex for Antibodies for GOT1
-
Custom Antibody ServicesProSci Antibodies for GOT1
-
Santa Cruz Biotechnology (SCBT) Antibodies for GOT1
- Sino Biological Antibodies for GOT1
Protein Products
-
OriGene Purified Proteins for GOT1
- Search Origene for MassSpec and Protein Over-expression Lysates for GOT1
- Origene Custom Protein Services for GOT1
- Sino Biological Recombinant Proteins for GOT1
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for GOT1
-
Cloud-Clone Corp. Proteins for GOT1
- Search GeneTex for Proteins for GOT1
-
ProSci Proteins for GOT1
-
Abcam proteins for GOT1
Assay Products
-
Cloud-Clone Corp. Assay Kits for GOT1
- antibodies-online: Search results for 70 available GOT1 Elisa Kits ranked by validation data
- Compare Top GOT1 Elisa Kits
-
Recommended
- 4 Chicken ELISA Kits
- 6 Cow (Bovine) ELISA Kits
- 1 Dog (Canine) ELISA Kit
- 2 Fish ELISA Kits
- 1 Goat ELISA Kit
- 1 Guinea Pig ELISA Kit
- 11 Human ELISA Kits
- 2 Monkey ELISA Kits
- 16 Mouse (Murine) ELISA Kits
- 5 Pig (Porcine) ELISA Kits
- 3 Rabbit ELISA Kits
- 15 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- ABIN593355
-
Abcam assays for GOT1
Domains & Families for GOT1 Gene
Gene Families for GOT1 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for GOT1 Gene
Suggested Antigen Peptide Sequences for GOT1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P17174UniProtKB/Swiss-Prot:
AATC_HUMAN :- Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
- Family:
-
- Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Function for GOT1 Gene
Molecular function for GOT1 Gene
- GENATLAS Biochemistry:
- glutamic-oxaloacetic transaminase 1,soluble (aspartate aminotransferase 1)
- UniProtKB/Swiss-Prot CatalyticActivity:
- L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate.
- UniProtKB/Swiss-Prot Function:
- Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
Enzyme Numbers (IUBMB) for GOT1 Gene
Phenotypes From GWAS Catalog for GOT1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity | TAS | -- |
GO:0004609 | phosphatidylserine decarboxylase activity | IEA | -- |
GO:0008483 | transaminase activity | IEA | -- |
GO:0016740 | transferase activity | IEA | -- |
GO:0030170 | pyridoxal phosphate binding | IEA | -- |
Phenotypes for GOT1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for GOT1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for GOT1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GOT1 gene
- Search ViGene Biosciences for GOT1
CRISPR Products
-
OriGene CRISPR knockouts for GOT1
- genomics-online: gRNA clones - Search results for available GOT1 gene related products
- Applied Biological Materials CRISPR for GOT1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GOT1
- GenScript: Design CRISPR guide RNA sequences for GOT1
miRNA for GOT1 Gene
- miRTarBase miRNAs that target GOT1
-
- hsa-mir-769-5p (MIRT039193)
- hsa-mir-7641 (MIRT497413)
- hsa-mir-4448 (MIRT497414)
- hsa-mir-549a (MIRT497415)
- hsa-mir-205-5p (MIRT497416)
- hsa-mir-1324 (MIRT497417)
- hsa-mir-3591-5p (MIRT645847)
- hsa-mir-483-3p (MIRT645848)
- hsa-mir-5003-5p (MIRT645849)
- hsa-mir-8485 (MIRT645850)
- hsa-mir-181d-5p (MIRT727535)
- hsa-mir-181c-5p (MIRT727536)
- hsa-mir-181a-5p (MIRT727537)
- hsa-mir-181b-5p (MIRT727538)
- hsa-mir-200b-3p (MIRT738765)
- hsa-mir-200c-3p (MIRT738777)
- hsa-mir-429 (MIRT743825)
- hsa-mir-452-5p (MIRT745939)
- hsa-mir-4676-3p (MIRT746894)
- hsa-mir-548a-3p (MIRT750465)
- hsa-mir-548ar-3p (MIRT750582)
- hsa-mir-548az-3p (MIRT750645)
- hsa-mir-548e-3p (MIRT750698)
- hsa-mir-548f-3p (MIRT750708)
- hsa-mir-5582-3p (MIRT750944)
- hsa-mir-6740-5p (MIRT754329)
- hsa-mir-892c-3p (MIRT760454)
miRNA Products
- Search ViGene Biosciences for GOT1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for GOT1
- Browse OriGene Inhibitory RNA Products For GOT1
- genomics-online: shRNA clones - Search results for available GOT1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GOT1 gene
Clone Products
- Sino Biological Human cDNA Clone for GOT1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for GOT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GOT1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GOT1
- genomics-online: cdna clones - Search results for available GOT1 gene related products
- orf clones - Search results for available GOT1 gene related products
- Applied Biological Materials Clones for GOT1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for GOT1
-
ViGene Biosciences adenoviral particle packaged cDNA for GOT1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GOT1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GOT1 gene
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOT1 Gene
Localization for GOT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GOT1 Gene
- Cytoplasm.
- Cytosol (3)
- Nucleoplasm (3)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA,HDA | 21630459 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IDA,IEA | 7060339 |
GO:0005739 | NOT mitochondrion | IBA | -- |
GO:0005764 | lysosome | IEA | -- |
Pathways & Interactions for GOT1 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Sulfur amino acid metabolism | ||
2 | Glucose metabolism |
.46
|
|
3 | Carbon metabolism | ||
4 | Phenylalanine metabolism | ||
5 | superpathway of methionine degradation |
Pathways by source for GOT1 Gene
11 BioSystems pathways for GOT1 Gene
9 Reactome pathways for GOT1 Gene
1 PharmGKB pathway for GOT1 Gene
Interacting Proteins for GOT1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006094 | gluconeogenesis | TAS | -- |
GO:0006103 | 2-oxoglutarate metabolic process | ISS | -- |
GO:0006107 | oxaloacetate metabolic process | IEA | -- |
GO:0006114 | glycerol biosynthetic process | IEA,ISS | -- |
GO:0006520 | cellular amino acid metabolic process | IEA | -- |
No data available for SIGNOR curated interactions for GOT1 Gene
Drugs & Compounds for GOT1 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Glutamic Acid | Approved | Nutra | Full agonist, Agonist, Target | 251 | ||
L-Aspartic acid | Approved | Nutra | Target | 0 | ||
L-Cysteine | Approved | Nutra | Target | 0 | ||
Pyridoxal Phosphate | Approved, Investigational | Nutra | Target, activator | 17 | ||
Copper | Approved, Investigational | Pharma | Target | 202 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
3-Mercaptopyruvic acid |
|
2464-23-5 |
|
|||
3-Sulfinylpyruvic acid |
|
|
||||
4-Hydroxy-2-oxoglutaric acid |
|
1187-99-1 |
|
|||
4-Hydroxy-L-glutamic acid |
|
2485-33-8 |
|
|||
4-Hydroxyphenylpyruvic acid |
|
156-39-8 |
|
Transcripts for GOT1 Gene
mRNA/cDNA for GOT1 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (584) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GOT1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GOT1
- genomics-online: gRNA clones - Search results for available GOT1 gene related products
- Applied Biological Materials CRISPR for GOT1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GOT1
- GenScript: Design CRISPR guide RNA sequences for GOT1
miRNA Products
- Search ViGene Biosciences for GOT1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for GOT1
- Browse OriGene Inhibitory RNA Products For GOT1
- genomics-online: shRNA clones - Search results for available GOT1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GOT1 gene
Clone Products
- Sino Biological Human cDNA Clone for GOT1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for GOT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GOT1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GOT1
- genomics-online: cdna clones - Search results for available GOT1 gene related products
- orf clones - Search results for available GOT1 gene related products
- Applied Biological Materials Clones for GOT1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for GOT1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Liver (Hepatobiliary System)
- Periportal Hepatocytes Liver Lobule
- Gut Tube (Gastrointestinal Tract)
- Kidney (Urinary System)
- Thymus (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for GOT1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GOT1 Gene
NURSA nuclear receptor signaling pathways regulating expression of GOT1 Gene:
GOT1SOURCE GeneReport for Unigene cluster for GOT1 Gene:
Hs.500756Evidence on tissue expression from TISSUES for GOT1 Gene
- Nervous system(5)
- Liver(4.7)
- Lung(4.5)
- Heart(4.1)
- Kidney(3.7)
- Muscle(3.3)
- Blood(2.3)
- Intestine(2.3)
Primer Products
-
OriGene qPCR primer pairs for GOT1
-
OriGene qPCR primer pairs and template standards for GOT1
- genomics-online: primer clones - Search results for available GOT1 gene related products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOT1 Gene
Orthologs for GOT1 Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | GOT1 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | GOT1 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | GOT1 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Got1 33 |
|
||
mouse (Mus musculus) |
Mammalia | Got1 33 16 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | GOT1 34 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | GOT1 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | GOT1 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | GOT1 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | got1 33 |
|
||
Str.556 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | xr406-prov 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | got1 33 34 |
|
||
Dr.28236 33 |
|
||||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3656 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Got1 33 34 |
|
||
CG8430 35 |
|
|
|||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004142 33 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | got-1.2 33 34 |
|
||
T01C8.5 35 |
|
|
|||
got-1.1 34 |
|
ManyToMany | |||
C14E2.2 35 |
|
|
|||
T01C8.4 35 |
|
|
|||
got-1.3 34 |
|
ManyToMany | |||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFR211C 33 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | AAT2 33 34 36 |
|
||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F17754g 33 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | ASP3 33 |
|
||
soybean (Glycine max) |
eudicotyledons | Gma.3139 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os01g0760600 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6560 34 |
|
OneToMany | |
bread mold (Neurospora crassa) |
Ascomycetes | NCU07941 33 |
|
||
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC10F6.13c 33 |
|
||
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.5022 33 |
|
- Species where no ortholog for GOT1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for GOT1 Gene
(3) SIMAP similar genes for GOT1 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for GOT1 Gene
Variants for GOT1 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for GOT1 Gene
- AATC_HUMAN-P17174
- Genetic variations in GOT1 are associated with low serum aspartate aminotransferase and define the aspartate aminotransferase serum level quantitative trait locus 1 (ASTQTL1) [MIM:614419].
SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000322922 | -- | 99,430,496(-) | C/A/T | coding_sequence_variant, missense_variant | |
rs1000369476 | -- | 99,416,098(-) | C/A | intron_variant | |
rs1000501085 | -- | 99,424,939(-) | A/G | intron_variant | |
rs1000510853 | -- | 99,421,651(-) | G/A | intron_variant | |
rs1000575634 | -- | 99,423,647(-) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3546741 | CNV | deletion | 23714750 |
Additional Variant Information for GOT1 Gene
Disorders for GOT1 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
aspartate aminotransferase, serum level of, quantitative trait locus 1 |
|
|
cholesterol ester storage disease |
|
|
histidine metabolism disease |
|
|
histidinemia |
|
|
lysosomal acid lipase deficiency |
|
|
Additional Disease Information for GOT1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for GOT1 Gene
Publications for GOT1 Gene
- Properties of human liver cytosolic aspartate aminotransferase mRNAs generated by alternative polyadenylation site selection. (PMID: 1974457) Bousquet-Lemercier B … Barouki R (Biochemistry 1990) 2 3 4 58
- Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels. (PMID: 21900944) Shen H … Gong DW (Journal of human genetics 2011) 3 4 58
- Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 44 58
- The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for GOT1 Gene
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- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody ServicesOriGene Antibodies for GOT1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for GOT1
- Search Origene for MassSpec and Protein Over-expression Lysates for GOT1
- Origene Custom Protein Services for GOT1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GOT1
- Browse OriGene Inhibitory RNA Products For GOT1
- OriGene qPCR primer pairs and template standards for GOT1
- OriGene qPCR primer pairs for GOT1
- OriGene CRISPR knockouts for GOT1
- OriGene ORF clones in human for GOT1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GOT1
- GenScript: Next-day shipping of latest version cDNA ORF clones for GOT1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for GOT1
- GenScript Custom Assay Services for GOT1
- GenScript Custom overexpressing Cell Line Services for GOT1
- GenScript: Design CRISPR guide RNA sequences for GOT1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for GOT1
- Sino Biological Human cDNA Clone for GOT1
- Sino Biological Recombinant Proteins for GOT1
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for GOT1
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for GOT1
- Novus Biologicals proteins and lysates for GOT1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for GOT1
- Abcam proteins for GOT1
- Abcam assays for GOT1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for GOT1
- Cloud-Clone Corp. Antibodies for GOT1
- Cloud-Clone Corp. Proteins for GOT1
- Cloud-Clone Corp. Assay Kits for GOT1
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for GOT1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for GOT1
- VectorBuilder custom plasmid, inducible vectors for GOT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GOT1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GOT1
- antibodies-online: Search results for 184 available GOT1 Antibodies ranked by validation data
- Compare Top GOT1 Antibodies
- antibodies-online: Search results for 70 available GOT1 Elisa Kits ranked by validation data
- Compare Top GOT1 Elisa Kits
- Recommended
- 4 Chicken ELISA Kits
- 6 Cow (Bovine) ELISA Kits
- 1 Dog (Canine) ELISA Kit
- 2 Fish ELISA Kits
- 1 Goat ELISA Kit
- 1 Guinea Pig ELISA Kit
- 11 Human ELISA Kits
- 2 Monkey ELISA Kits
- 16 Mouse (Murine) ELISA Kits
- 5 Pig (Porcine) ELISA Kits
- 3 Rabbit ELISA Kits
- 15 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- ABIN593355
- antibodies-online: Search results for 29 available GOT1 Proteins ranked by validation data
- Compare Top GOT1 Proteins
- Search GeneTex for Antibodies for GOT1
- Search GeneTex for Proteins for GOT1
- ViGene Biosciences adenoviral particle packaged cDNA for GOT1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for GOT1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for GOT1 gene
- Search ViGene Biosciences for GOT1
- Santa Cruz Biotechnology (SCBT) Antibodies for GOT1
- Search Santa Cruz Biotechnology (SCBT) for GOT1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GOT1
- Custom Antibody ServicesProSci Antibodies for GOT1
- ProSci Proteins for GOT1
- Horizon Cell Lines for GOT1
- genomics-online: cdna clones - Search results for available GOT1 gene related products
- orf clones - Search results for available GOT1 gene related products
- genomics-online: gRNA clones - Search results for available GOT1 gene related products
- genomics-online: primer clones - Search results for available GOT1 gene related products
- genomics-online: shRNA clones - Search results for available GOT1 gene related products
Sources for GOT1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew