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Aliases for GOT1 Gene

Aliases for GOT1 Gene

  • Glutamic-Oxaloacetic Transaminase 1, Soluble 2 3
  • Cysteine Aminotransferase, Cytoplasmic 3 4
  • Glutamate Oxaloacetate Transaminase 1 3 4
  • Cysteine Transaminase, Cytoplasmic 3 4
  • Aspartate Aminotransferase 1 2 3
  • Aspartate Transaminase 1 2 3
  • Transaminase A 3 4
  • EC 2.6.1.1 4 63
  • ASTQTL1 3 6
  • CAspAT 3 4
  • CCAT 3 4
  • Glutamic-Oxaloacetic Transaminase 1, Soluble (Aspartate Aminotransferase 1) 2
  • Aspartate Aminotransferase, Cytoplasmic 3
  • Growth-Inhibiting Protein 18 3
  • EC 2.6.1.3 4
  • GIG18 3

External Ids for GOT1 Gene

Previous GeneCards Identifiers for GOT1 Gene

  • GC10M100049
  • GC10M100390
  • GC10M101287
  • GC10M100821
  • GC10M101146
  • GC10M094783

Summaries for GOT1 Gene

Entrez Gene Summary for GOT1 Gene

  • Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]

GeneCards Summary for GOT1 Gene

GOT1 (Glutamic-Oxaloacetic Transaminase 1, Soluble) is a Protein Coding gene. Diseases associated with GOT1 include aspartate aminotransferase, serum level of, qtl1 and exanthem. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include pyridoxal phosphate binding and carboxylic acid binding. An important paralog of this gene is GOT1L1.

UniProtKB/Swiss-Prot for GOT1 Gene

  • Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.

Gene Wiki entry for GOT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOT1 Gene

Genomics for GOT1 Gene

Regulatory Elements for GOT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GOT1 Gene

Start:
99,396,870 bp from pter
End:
99,430,773 bp from pter
Size:
33,904 bases
Orientation:
Minus strand

Genomic View for GOT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GOT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOT1 Gene

Proteins for GOT1 Gene

  • Protein details for GOT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17174-AATC_HUMAN
    Recommended name:
    Aspartate aminotransferase, cytoplasmic
    Protein Accession:
    P17174
    Secondary Accessions:
    • B2R6R7
    • B7Z7E9
    • Q5VW80

    Protein attributes for GOT1 Gene

    Size:
    413 amino acids
    Molecular mass:
    46248 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Aspartate aminotransferase activity found to be increased in cerebral spinal fluid (CSF) of patients with Alzheimer disease (PubMed:16039064). Fetal serum levels of the enzyme in the umbilical artery and vein are found to be significantly higher than maternal serum levels (PubMed:22633534).
    • In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes

    Three dimensional structures from OCA and Proteopedia for GOT1 Gene

    Alternative splice isoforms for GOT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOT1 Gene

Proteomics data for GOT1 Gene at MOPED

Post-translational modifications for GOT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GOT1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for GOT1 Gene

Suggested Antigen Peptide Sequences for GOT1 Gene

Graphical View of Domain Structure for InterPro Entry

P17174

UniProtKB/Swiss-Prot:

AATC_HUMAN :
  • P17174
Family:
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
genes like me logo Genes that share domains with GOT1: view

No data available for Gene Families for GOT1 Gene

Function for GOT1 Gene

Molecular function for GOT1 Gene

GENATLAS Biochemistry:
glutamic-oxaloacetic transaminase 1,soluble (aspartate aminotransferase 1)
UniProtKB/Swiss-Prot CatalyticActivity:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate
UniProtKB/Swiss-Prot CatalyticActivity:
L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate
UniProtKB/Swiss-Prot Function:
Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.

Enzyme Numbers (IUBMB) for GOT1 Gene

Gene Ontology (GO) - Molecular Function for GOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity TAS --
GO:0004609 phosphatidylserine decarboxylase activity IEA --
GO:0008483 transaminase activity --
GO:0030170 pyridoxal phosphate binding IEA --
GO:0031406 carboxylic acid binding IEA --
genes like me logo Genes that share ontologies with GOT1: view

Phenotypes for GOT1 Gene

genes like me logo Genes that share phenotypes with GOT1: view

Animal Model Products

miRNA for GOT1 Gene

miRTarBase miRNAs that target GOT1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GOT1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for GOT1 Gene

Localization for GOT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOT1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GOT1 Gene COMPARTMENTS Subcellular localization image for GOT1 gene
Compartment Confidence
cytosol 4
extracellular 3
mitochondrion 3
lysosome 2
nucleus 2
peroxisome 2
plasma membrane 2
vacuole 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IDA 7060339
GO:0005764 lysosome IEA --
GO:0005829 cytosol TAS --
GO:0043679 axon terminus IEA --
genes like me logo Genes that share ontologies with GOT1: view

Pathways for GOT1 Gene

genes like me logo Genes that share pathways with GOT1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000096 sulfur amino acid metabolic process TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006006 glucose metabolic process TAS --
GO:0006094 gluconeogenesis TAS --
GO:0006103 2-oxoglutarate metabolic process ISS --
genes like me logo Genes that share ontologies with GOT1: view

Compounds for GOT1 Gene

(18) HMDB Compounds for GOT1 Gene

Compound Synonyms Cas Number PubMed IDs
3-Mercaptopyruvic acid
  • 3-Mercaptopyruvate
2464-23-5
3-Sulfinoalanine
  • 3-Sulphino-L-alanine
1115-65-7
3-Sulfinylpyruvic acid
  • 3-Sulfinopyruvate
Not Available
3-Sulfopyruvic acid
  • 3-sulfopyruvate
98022-26-5
4-Hydroxy-2-oxoglutaric acid
  • (+/-)-2-hydroxy-4-oxopentanedioate
1187-99-1

(5) Drugbank Compounds for GOT1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Aspartic Acid
  • (+)-Aspartic acid
56-84-8 target
L-Cysteine
  • (R)-2-Amino-3-mercaptopropanoic acid
52-90-4 target
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target
Maleic Acid
110-16-7 target
Pyridoxal Phosphate
  • Codecarboxylase
54-47-7 target activator
genes like me logo Genes that share compounds with GOT1: view

Transcripts for GOT1 Gene

mRNA/cDNA for GOT1 Gene

Unigene Clusters for GOT1 Gene

Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GOT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOT1 Gene

No ASD Table

Relevant External Links for GOT1 Gene

GeneLoc Exon Structure for
GOT1
ECgene alternative splicing isoforms for
GOT1

Expression for GOT1 Gene

mRNA expression in normal human tissues for GOT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GOT1 Gene

This gene is overexpressed in Heart - Left Ventricle (7.8), Liver (5.5), Muscle - Skeletal (4.3), and Heart - Atrial Appendage (4.3).

Protein differential expression in normal tissues for GOT1 Gene

This gene is overexpressed in Liver, secretome (13.5), Heart (7.6), and Tonsil (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GOT1 Gene

SOURCE GeneReport for Unigene cluster for GOT1 Gene Hs.500756

genes like me logo Genes that share expressions with GOT1: view

Expression partners for GOT1 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GOT1 Gene

Orthologs for GOT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GOT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GOT1 35
  • 89.51 (n)
  • 91.53 (a)
GOT1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GOT1 35
  • 89.43 (n)
  • 92.49 (a)
GOT1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Got1 35
  • 87.09 (n)
  • 90.8 (a)
Got1 16
Got1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GOT1 35
  • 99.68 (n)
  • 99.76 (a)
GOT1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Got1 35
  • 87.49 (n)
  • 90.31 (a)
oppossum
(Monodelphis domestica)
Mammalia GOT1 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GOT1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves GOT1 35
  • 76.12 (n)
  • 80.44 (a)
GOT1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GOT1 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia got1 35
  • 73.43 (n)
  • 80.93 (a)
Str.556 35
African clawed frog
(Xenopus laevis)
Amphibia xr406-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.28236 35
got1 35
  • 72.45 (n)
  • 77.02 (a)
got1 36
  • 77 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3656 35
fruit fly
(Drosophila melanogaster)
Insecta CG8430 37
  • 56 (a)
Got1 35
  • 59.27 (n)
  • 57.11 (a)
Got1 36
  • 52 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004142 35
  • 58.54 (n)
  • 61.19 (a)
worm
(Caenorhabditis elegans)
Secernentea C14E2.2 37
  • 47 (a)
T01C8.4 37
  • 41 (a)
T01C8.5 37
  • 53 (a)
got-1.2 35
  • 58.5 (n)
  • 54.46 (a)
got-1.1 36
  • 51 (a)
ManyToMany
got-1.2 36
  • 54 (a)
ManyToMany
got-1.3 36
  • 37 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR211C 35
  • 51.88 (n)
  • 48.12 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17754g 35
  • 50.86 (n)
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAT2 35
  • 51.8 (n)
  • 48.12 (a)
AAT2 36
  • 46 (a)
OneToMany
AAT2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ASP3 35
  • 55.61 (n)
  • 50.62 (a)
soybean
(Glycine max)
eudicotyledons Gma.3139 35
rice
(Oryza sativa)
Liliopsida Os01g0760600 35
  • 55.94 (n)
  • 51.35 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5022 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07941 35
  • 54.59 (n)
  • 53.1 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC10F6.13c 35
  • 51.03 (n)
  • 47.39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6560 36
  • 57 (a)
OneToMany
Species with no ortholog for GOT1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GOT1 Gene

ENSEMBL:
Gene Tree for GOT1 (if available)
TreeFam:
Gene Tree for GOT1 (if available)

Paralogs for GOT1 Gene

Paralogs for GOT1 Gene

Selected SIMAP similar genes for GOT1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for GOT1 Gene

genes like me logo Genes that share paralogs with GOT1: view

Variants for GOT1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GOT1 Gene

P17174-AATC_HUMAN
Genetic variations in GOT1 are associated with low serum aspartate aminotransferase and define the aspartate aminotransferase serum level quantitative trait locus 1 (ASTQTL1) [MIM:614419]

Sequence variations from dbSNP and Humsavar for GOT1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2641 -- 99,397,002(+) ATGTA(C/T)GTGTC utr-variant-3-prime
rs2642 -- 99,396,992(+) TCAGT(C/T)AAATA utr-variant-3-prime
rs11867 -- 99,397,403(-) TAAAC(C/T)GGCCC utr-variant-3-prime
rs1126878 -- 99,397,224(-) CTTCT(A/C)TGTGG utr-variant-3-prime
rs1126927 -- 99,396,892(-) AAAAA(A/T)AAAAT utr-variant-3-prime

Relevant External Links for GOT1 Gene

HapMap Linkage Disequilibrium report
GOT1
Human Gene Mutation Database (HGMD)
GOT1

No data available for Structural Variations from Database of Genomic Variants (DGV) for GOT1 Gene

Disorders for GOT1 Gene

(1) OMIM Diseases for GOT1 Gene (138180)

Relevant External Links for GOT1

Genetic Association Database (GAD)
GOT1
Human Genome Epidemiology (HuGE) Navigator
GOT1
genes like me logo Genes that share disorders with GOT1: view

No data available for UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for GOT1 Gene

Publications for GOT1 Gene

  1. Properties of human liver cytosolic aspartate aminotransferase mRNAs generated by alternative polyadenylation site selection. (PMID: 1974457) Bousquet-Lemercier B. … Barouki R. (Biochemistry 1990) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  3. Genetic homogeneity, high-resolution mapping, and mutation analysis of the urofacial (Ochoa) syndrome and exclusion of the glutamate oxaloacetate transaminase gene (GOT1) in the critical region as the disease gene. (PMID: 10360399) Wang C.Y. … She J.X. (Am. J. Med. Genet. 1999) 3 23
  4. The amino acid sequence of cytosolic aspartate aminotransferase from human liver. (PMID: 2241899) Doyle J.M. … Doonan S. (Biochem. J. 1990) 3 4
  5. Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels. (PMID: 21900944) Shen H. … Gong D.W. (J. Hum. Genet. 2011) 3 4

Products for GOT1 Gene

  • Addgene plasmids for GOT1

Sources for GOT1 Gene

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