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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GOT1 Gene

protein-coding   GIFtS: 66
GCID: GC10M101146

Glutamic-Oxaloacetic Transaminase 1, Soluble

(Previous names: glutamic-oxaloacetic transaminase 1, soluble (aspartate...)
  See related diseases
at
MalaCards
 

Aliases
for GOT1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Glutamic-Oxaloacetic Transaminase 1, Soluble1 2     cCAT2 3
Aspartate Aminotransferase 11 2     EC 2.6.1.13 8
Aspartate Transaminase 11 2     Glutamic-Oxaloacetic Transaminase 1, Soluble (Aspartate Aminotransferase
1)1
Cysteine Aminotransferase, Cytoplasmic2 3     ASTQTL12
Cysteine Transaminase, Cytoplasmic2 3     GIG182
Glutamate Oxaloacetate Transaminase 12 3     Aspartate Aminotransferase, Cytoplasmic2
Transaminase A2 3     Growth-Inhibiting Protein 182
cAspAT2 3     EC 2.6.1.33

External Ids:    HGNC: 44321   Entrez Gene: 28052   Ensembl: ENSG000001200537   OMIM: 1381805   UniProtKB: P171743   

Export aliases for GOT1 gene to outside databases

Previous GC identifers: GC10M100049 GC10M100390 GC10M101287 GC10M100821 GC10M094783


Summaries
for GOT1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GOT1 Gene:
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and
mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and
tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. (provided by RefSeq, Jul
2008)

GeneCards Summary for GOT1 Gene: 
GOT1 (glutamic-oxaloacetic transaminase 1, soluble) is a protein-coding gene. Diseases associated with GOT1 include ochoa syndrome, and gallbladder disease, and among its related super-pathways are glutamate degradation II and Metabolic pathways. GO annotations related to this gene include pyridoxal phosphate binding and carboxylic acid binding. An important paralog of this gene is GOT2.

UniProtKB/Swiss-Prot: AATC_HUMAN, P17174
Function: Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate,
the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate
in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during
development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of
mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the
action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and
neuroprotectant in the brain

Gene Wiki entry for GOT1 Gene


Genomic Views
for GOT1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GOT1 gene promoter:
         STAT1   STAT1beta   Egr-4   STAT1alpha   AREB6   Egr-2   PPAR-gamma1   FOXO1a   PPAR-gamma2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GOT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GOT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GOT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.1-q25.1   Ensembl cytogenetic band:  10q24.2   HGNC cytogenetic band: 10q24.1-q25.1

GOT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GOT1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M101146:  view genomic region     (about GC identifiers)

Start:
 101,156,627 bp from pter      End:
 101,190,530 bp from pter
Size:
 33,904 bases      Orientation:
 minus strand

Proteins
for GOT1 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: AATC_HUMAN, P17174 (See protein sequence)
Recommended Name: Aspartate aminotransferase, cytoplasmic  
Size: 413 amino acids; 46248 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer
Subcellular location: Cytoplasm
Miscellaneous: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes
Miscellaneous: Aspartate aminotransferase activity found to be increased in cerebral spinal fluid (CSF) of
patients with Alzheimer disease (PubMed:16039064). Fetal serum levels of the enzyme in the umbilical artery and
vein are found to be significantly higher than maternal serum levels (PubMed:22633534)
1 PDB 3D structure from and Proteopedia for GOT1:
3II0 (3D)    
Secondary accessions: B2R6R7 Q5VW80

Explore the universe of human proteins at neXtProt for GOT1: NX_P17174

Explore proteomics data for GOT1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17174

    • 4/21 DME Specific Peptides for GOT1 (P17174) (see all 21)
     DPTPEQW  EKRVGGV  CAHNPTG  AGFKDIR 

    GOT1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GOT1 Protein Expression
    REFSEQ proteins: NP_002070.1  
    ENSEMBL proteins: 
     ENSP00000359539   ENSP00000445578  
    Reactome Protein details: P17174
    Human Recombinant Protein Products for GOT1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for GOT1
    OriGene Protein Over-expression Lysate for GOT1
    OriGene MassSpec for GOT1 
    OriGene Custom Protein Services for GOT1
    GenScript Custom Purified and Recombinant Proteins Services for GOT1
    Novus Biologicals GOT1 Proteins
    Novus Biologicals GOT1 Lysates
    Sino Biological Recombinant Protein for GOT1
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for GOT1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA7060339
    GO:0005764lysosome IEA--
    GO:0005829cytosol TAS--
    GO:0043679axon terminus IEA--

    GOT1 for ontologies           About GeneDecksing



    GOT1 Antibody Products: 
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    Novus Biologicals GOT1 Antibodies
    Abcam antibodies for GOT1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for GOT1
    LSBio Antibodies in human, mouse, rat for GOT1 

    Assay Products for GOT1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GOT1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GOT1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.

    Protein Domains /
    Families
    for GOT1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 5 InterPro protein domains:
     IPR004838 NHTrfase_class1_PyrdxlP-BS
     IPR004839 Aminotransferase_I/II
     IPR015424 PyrdxlP-dep_Trfase
     IPR000796 Asp_trans
     IPR015421 PyrdxlP-dep_Trfase_major_sub1

    Graphical View of Domain Structure for InterPro Entry P17174

    ProtoNet protein and cluster: P17174

    3 Blocks protein domains:
    IPB000796 Aspartate aminotransferase signature
    IPB004838 Aminotransferase
    IPB004839 Aminotransferase


    UniProtKB/Swiss-Prot: AATC_HUMAN, P17174
    Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family


    GOT1 for domains           About GeneDecksing


    Function
    for GOT1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AATC_HUMAN, P17174
    Function: Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate,
    the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate
    in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during
    development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of
    mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the
    action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and
    neuroprotectant in the brain
    Catalytic activity: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate
    Catalytic activity: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate

         Genatlas biochemistry entry for GOT1:
    glutamic-oxaloacetic transaminase 1,soluble (aspartate aminotransferase 1)

         Enzyme Numbers (IUBMB): EC 2.6.1.11 2 EC 2.6.1.31

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004069L-aspartate:2-oxoglutarate aminotransferase activity TAS--
    GO:0004609phosphatidylserine decarboxylase activity IEA--
    GO:0008483transaminase activity TAS--
    GO:0030170pyridoxal phosphate binding IEA--
    GO:0031406carboxylic acid binding IEA--
         
    GOT1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for GOT1:
     Elongated cells  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GOT1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GOT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GOT1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GOT1 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GOT1
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate GOT1:
    hsa-miR-876-3p hsa-miR-9 hsa-miR-3122 hsa-miR-1276 hsa-miR-3913-5p hsa-miR-3151 hsa-miR-323-5p hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmid: GOT1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GOT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GOT1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for GOT1
    Sirion Biotech Customized adenovirus for overexpression of GOT1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GOT1 (see all 8)
    OriGene ORF clones in mouse, rat for GOT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GOT1 (NM_002079)
    Sino Biological Human cDNA Clone for GOT1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GOT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GOT1
    Sirion Biotech Customized lentivirus for stable overexpression of GOT1 
                         Customized lentivirus expression plasmids for stable overexpression of GOT1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for GOT1
    Search LifeMap BioReagents cell lines for GOT1
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOT1


    Pathways & Interactions
    for GOT1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GOT1 About   (see all 20)                                                                                              See pathways by source

    SuperPathContained pathways About
    1glutamate degradation II
    		glutamate degradation II0.75
    		aspartate biosynthesis0.75
    		aspartate degradation II0.75
    		Phenylalanine, tyrosine and tryptophan biosynthesis0.33
    2Metabolism
    		Metabolism0.40
    		Metabolic pathways0.40
    3Cysteine and methionine metabolism
    		Cysteine and methionine metabolism0.37
    		Sulfur amino acid metabolism0.37
    4phenylalanine utilization
    		phenylalanine degradation IV (mammalian, via side chain)0.70
    		phenylalanine utilization0.70
    5Methionine salvage pathway
    		Methionine salvage pathway0.67
    		Metabolism of polyamines0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/10 BioSystems Pathways for GOT1 (see all 10)
        Trans-sulfuration pathway
    Alanine and aspartate metabolism
    Glycolysis and Gluconeogenesis
    phenylalanine degradation IV (mammalian, via side chain)
    aspartate degradation II


    5/9        Reactome Pathways for GOT1 (see all 9)
        Gluconeogenesis
    Metabolism of carbohydrates
    Metabolism of polyamines
    Metabolism
    Methionine salvage pathway

    1 PharmGKB Pathway for GOT1
        Valproic Acid Pathway, Pharmacodynamics

    5/9         Kegg Pathways  (Kegg details for GOT1) (see all 9):
        Alanine, aspartate and glutamate metabolism
    Cysteine and methionine metabolism
    Arginine and proline metabolism
    Tyrosine metabolism
    Phenylalanine metabolism


    GOT1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GOT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/209 Interacting proteins for GOT1 (P171742, 3 ENSP000003595394) via UniProtKB, MINT, STRING, and/or I2D (see all 209)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000096sulfur amino acid metabolic process TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006006glucose metabolic process TAS--
    GO:0006094gluconeogenesis TAS--
    GO:00061032-oxoglutarate metabolic process ISS--

    GOT1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GOT1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GOT1 (AATC)

    10/18 HMDB Compounds for GOT1 (see all 18)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Mercaptopyruvic acid3-Mercaptopyruvate (see all 13)2464-23-5--
    3-Sulfinoalanine3-Sulphino-L-alanine (see all 9)1115-65-7--
    3-Sulfinylpyruvic acid3-Sulfinopyruvate (see all 5)----
    3-Sulfopyruvic acid3-sulfopyruvate (see all 8)98022-26-5--
    4-Hydroxy-2-oxoglutaric acid(+/-)-2-hydroxy-4-oxopentanedioate (see all 9)1187-99-1--
    4-Hydroxy-L-glutamic acid4-hydroxy-L-glutamate (see all 7)2485-33-8--
    4-Hydroxyphenylpyruvic acid(p-Hydroxyphenyl)pyruvate (see all 25)156-39-8--
    Cysteic acid2-Amino-3-sulfopropionate (see all 19)498-40-8--
    FamotidineAmfamox (see all 83)76824-35-6--
    L-Aspartic acid(+)-Aspartate (see all 41)56-84-8--

    5 DrugBank Compounds for GOT1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Aspartic Acid(+)-Aspartic acid (see all 23)56-84-8target--17244260 17328883 17168267 17442055 17545671
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetactivator12167474 11752352 16925884 11340119 11888303
    L-Cysteine(R)-2-Amino-3-mercaptopropanoic acid (see all 13)52-90-4target--17139284 17016423
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--17444813
    Maleic Acid-- 110-16-7target--10592235

    Search CenterWatch for drugs/clinical trials and news about GOT1 / AATC

    Transcripts
    for GOT1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GOT1 gene: 
    NM_002079.2  

    Unigene Cluster for GOT1:

    Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
    Hs.500756  [show with all ESTs]
    Unigene Representative Sequence: NM_002079
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370508(uc001kpr.3 uc009xwi.2) ENST00000489349 ENST00000471741
    ENST00000543866
    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate GOT1:
    hsa-miR-876-3p hsa-miR-9 hsa-miR-3122 hsa-miR-1276 hsa-miR-3913-5p hsa-miR-3151 hsa-miR-323-5p hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmid: GOT1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for GOT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GOT1
    Clone
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    OriGene ORF clones in mouse, rat for GOT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GOT1 (NM_002079)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GOT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GOT1
    Sirion Biotech Customized lentivirus for stable overexpression of GOT1 
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for GOT1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GOT1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GOT1

    Additional mRNA sequence: 

    AF052153.1 AK293483.1 AK301916.1 AK309174.1 AK312684.1 AY513279.1 BC000498.2 M37400.1 

    18 DOTS entries:

    DT.95161440  DT.100880095  DT.450537  DT.100767584  DT.100880100  DT.121276203  DT.95161437  DT.100880101 
    DT.91766831  DT.91766816  DT.102823882  DT.121276217  DT.86843273  DT.91766828  DT.95161431  DT.97854688 
    DT.100743022  DT.101979725 

    24/584 AceView cDNA sequences (see all 584):

    AI365638 BM980073 AV651306 CR625110 BC000498 BM667358 BQ440303 CR598904 
    CR619243 M37400 W87692 CR626608 F02675 BQ574228 BQ894358 NM_002079 
    CR622320 CR620721 BF939471 T39932 BG107325 BM671799 CR601723 BM832399 

    GeneLoc Exon Structure


    Expression
    for GOT1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GOT1 expression in normal human tissues (normalized intensities)      GOT1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACGGACACG
    GOT1 Expression
    About this image


    GOT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
             ganglion/cranial   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See GOT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GOT1

    SOURCE GeneReport for Unigene cluster: Hs.500756
        SABiosciences Expression via Pathway-Focused PCR Array including GOT1: 
              Amino Acid Metabolism II in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for GOT1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GOT1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GOT1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GOT1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOT1

    Orthologs
    for GOT1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GOT1 gene from 10/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Got11 , 5 glutamate oxaloacetate transaminase 1, soluble1, 5 87.09(n)1
    90.8(a)1    		   19 (36.67 cM)5
    147181  NM_010324.21  NP_034454.21 
     434997525 
    chicken
    (Gallus gallus)    		 Aves GOT11 glutamic-oxaloacetic transaminase 1, soluble (aspartate more 76.12(n)
    80.44(a)    		   396261  NM_205321.1  NP_990652.1 
    lizard
    (Anolis carolinensis)    		 Reptilia GOT16
    		 Aspartate aminotransferase
    		 81(a)
    		 1 ↔ 1
    		 3(38473516-38490723)
    African clawed frog
    (Xenopus laevis)    		 Amphibia xr406-prov2 Aspartate aminotransferase 75.29(n)    BC045269.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.282362 Danio rerio cDNA clone MGC55996 IMAGE3819704, complete more 75.9(n)    BC047800.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG84303
    Got11    		 aspartate aminotransferase3
    Glutamate oxaloacetate transaminase 11    		 56(a)3
    59.1(n)1
    56.86(a)1    		   367821  NM_166148.11  NP_725534.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea T01C8.53
    got-1.21    		 aminotransferase3
    Protein GOT-1.21    		 53(a)
    (best of 3)3
    58.5(n)1
    54.46(a)1    		   X(16822325-16823912)3
    1817261  NM_078308.41  NP_510709.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes AAT2(YLR027C)4
    AAT21    		 Cytosolic aspartate aminotransferase, involved in nitrogen more4
    Aat2p1    		 51.63(n)1
    48.12(a)1    		   12(198085-196829)4
    8507141, 4  NP_013127.21, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ASP31 aspartate aminotransferase 55.61(n)
    50.62(a)    		   831024  NM_121190.2  NP_196713.1 
    rice
    (Oryza sativa)    		 Liliopsida Os01g07606001 hypothetical protein 55.94(n)
    51.35(a)    		   4325621  NM_001050852.1  NP_001044317.1 


    ENSEMBL Gene Tree for GOT1 (if available)
    TreeFam Gene Tree for GOT1 (if available)

    Paralogs
    for GOT1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GOT1 gene
    GOT22  GOT1L12  
    3 SIMAP similar genes for GOT1 using alignment to 2 protein entries:     AATC_HUMAN (see all proteins):
    GIG18    GOT2    GOT1L1

    GOT1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GOT1
    PGOHUM00000249433


    Genomic Variants
    for GOT1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: AATC_HUMAN, P17174
    Polymorphism: Genetic variations in GOT1 are associated with low serum aspartate aminotransferase and define the
    aspartate aminotransferase serum level quantitative trait locus 1 (ASTQTL1) [MIM:614419]


    10/646 SNPs in GOT1 are shown (see all 646)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1996898091,2
    		C--101158427(+) AAAAA-/AGAATT 1 -- int10--------
    rs57873361,2
    		C--101166940(+) CATTAGT/-GTGTG 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs106688921,2
    		C--101167543(+) TATTTATTT/-  
                TACTT     		1 -- int11Minor allele frequency- -:0.00NA 2
    rs672708821,2
    		C--101177817(+) AAAAAT/AATATA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs113947461,2
    		C--101178251(+) TTTTT-/T/TT  
                CTTTT     		1 -- int1 trp31NA 2
    rs1494229631,2
    		--101518023(+) GAATTA/GACTTT 1 -- ds50010--------
    rs1162763971,2
    		C,F--101518056(+) ATAGAC/TCTCTT 1 -- ds50011Minor allele frequency- T:0.05WA 118
    rs1154516831,2
    		C,F--101518071(+) TAAGTA/GACATC 1 -- ds50011Minor allele frequency- G:0.01WA 118
    rs1915767661,2
    		--101518114(+) GGAGCA/GGCCCT 1 -- ds50010--------
    rs122175841,2
    		F,A,H--101518204(+) CTGATG/TTTCTA 1 -- ds50014Minor allele frequency- T:0.01NS EA 414

    HapMap Linkage Disequilibrium report for GOT1 (101156627 - 101190530 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GOT1: --

    Human Gene Mutation Database (HGMD): GOT1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GOT1
    DNA2.0 Custom Variant and Variant Library Synthesis for GOT1

    Disorders / Diseases
    for GOT1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 138180    OMIM disorders: --

    20/38 diseases for GOT1 (see all 38):    About MalaCards
    ochoa syndrome    gallbladder disease    acute pyelonephritis    reye syndrome
    pyelonephritis    substance abuse    severe acute respiratory syndrome    leukopenia
    hepatitis a    osteopetrosis    glucose intolerance    autoimmune hepatitis
    primary biliary cirrhosis    periodontal disease    cholangitis    fatty liver disease
    thrombocytopenia    diarrhea    cholestasis    brain disease

    20/24 diseases from the University of Copenhagen DISEASES database for GOT1 (see all 24):
    Liver disease     Fatty liver disease     Hepatitis B     Hepatitis C
    Cholestasis     Vascular disease     Thrombocytopenia     Hepatocellular carcinoma
    Autoimmune hepatitis     Cholangitis     Diarrhea     Myocardial infarction
    Substance abuse     Hepatitis A     Leukopenia     Diabetes mellitus
    Bilirubin metabolic disorder     Anemia     Myopathy     Exanthem

    GOT1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GOT1
    Human Genome Epidemiology (HuGE) Navigator: GOT1 (3 documents)

    Export disorders for GOT1 gene to outside databases

    Publications
    for GOT1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GOT1 gene, integrated from 9 sources (see all 80):
    (articles sorted by number of sources associating them with GOT1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Properties of human liver cytosolic aspartate aminotransferase mRNAs generated by alternative polyadenylation site selection. (PubMed id 1974457)1, 2, 3 Bousquet-Lemercier B.... Barouki R. (1990)
    2. Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels. (PubMed id 21900944)1, 2 Shen H.... Gong D.W. (2011)
    3. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The amino acid sequence of cytosolic aspartate aminotransferase from human liver. (PubMed id 2241899)1, 2 Doyle J.M.... Doonan S. (1990)
    7. Genetic homogeneity, high-resolution mapping, and mutation analysis of the urofacial (Ochoa) syndrome and exclusion of the glutamate oxaloacetate transaminase gene (GOT1) in the critical region as the disease gene. (PubMed id 10360399)1, 9 Wang C.Y....She J.X. (1999)
    8. Elevated aspartate and alanine aminotransferase levels and natural death among patients with methamphetamine dependence. (PubMed id 22242166)1 Kuo C.J....Chen W.J. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Relationship between glutamate, GOT and GPT levels in maternal and fetal blood: a potential mechanism for fetal neuroprotection. (PubMed id 22633534)2 Zlotnik A.... Teichberg V.I. (2012)

    External Searches for GOT1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing GOT1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2805 HGNC: 4432 AceView: GOT1 Ensembl:ENSG00000120053 euGenes: HUgn2805
    ECgene: GOT1 Kegg: 2805 H-InvDB: GOT1

    Other Databases showing GOT1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GOT1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GOT1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GOT1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GOT1 gene:
    Search GeneIP for patents involving GOT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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