GOT1 Gene
protein-coding GIFtS: 63
GCID: GC10M101146
|
|
glutamic-oxaloacetic transaminase 1, soluble (aspartate...
| |
Aliases
for GOT1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Glutamic-Oxaloacetic Transaminase 1, Soluble (Aspartate Aminotransferase1)1 2 | | ASTQTL12 | | Glutamate Oxaloacetate Transaminase 12 3 | | GIG182 | | Transaminase A2 3 | | Aspartate Aminotransferase, Cytoplasmic2 | | EC 2.6.1.13 8 | | Growth-Inhibiting Protein 182 |
Export aliases for GOT1 gene to outside databasesPrevious GC identifers: GC10M100049 GC10M100390 GC10M101287 GC10M100821 GC10M094783 |
Summaries
for GOT1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GOT1:
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic andmitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea andtricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: AATC_HUMAN, P17174Function: Plays a key role in amino acid metabolism (By similarity)
Gene Wiki entry for GOT1
|
Genomic Views
for GOT1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GOT1 gene promoter:
STAT1 STAT1beta Egr-4 STAT1alpha AREB6 Egr-2 PPAR-gamma1 FOXO1a PPAR-gamma2 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for GOT1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GOT1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q24.1-q25.1 Ensembl cytogenetic band: 10q24.2 HGNC cytogenetic band: 10q24.1-q25.1GOT1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M101146: view genomic region
(about GC identifiers)
Start:
|
101,156,627 bp from pter |
End:
|
101,190,530 bp from pter |
Size:
|
33,904 bases |
Orientation:
|
minus strand |
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Proteins
for GOT1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AATC_HUMAN, P17174 (See
protein sequence)Recommended Name: Aspartate aminotransferase, cytoplasmic Size: 413 amino acids; 46248 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer
Subcellular location: Cytoplasm
Miscellaneous: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes
1 PDB 3D structure from  and Proteopedia  for GOT1:3II0 (3D)
Secondary accessions: B2R6R7 Q5VW80Explore the universe of human proteins at neXtProt for GOT1: NX_P17174
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P17174
4/21 DME Specific Peptides for GOT1 (P17174) (see all 21)
GOT1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002070.1
ENSEMBL proteins: ENSP00000359539 ENSP00000445578 Reactome Protein details: P17174
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
GOT1 for ontologies About GeneDecksing
GOT1 Antibody Products:
Assay Products for GOT1: |
Protein
Domains /
Families
for GOT1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GOT1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P17174ProtoNet protein and cluster: P17174 3 Blocks protein families: IPB000796 Aspartate aminotransferase signature IPB004838 Aminotransferase IPB004839 Aminotransferase
UniProtKB/Swiss-Prot: AATC_HUMAN, P17174Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family |
Function
for GOT1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AATC_HUMAN, P17174Function: Plays a key role in amino acid metabolism (By similarity)Catalytic activity: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate Genatlas biochemistry entry for GOT1:glutamic-oxaloacetic transaminase 1,soluble (aspartate aminotransferase 1)
Enzyme Number (IUBMB): EC 2.6.1.11 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GOT1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GOT1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: GOT1 (NM_002079) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GOT1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GOT1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOT1 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity |
TAS | -- | | GO:0004609 | phosphatidylserine decarboxylase activity |
IEA | -- | | GO:0008483 | transaminase activity |
TAS | -- | | GO:0030170 | pyridoxal phosphate binding |
IEA | -- | | GO:0031406 | carboxylic acid binding |
IEA | -- |
GOT1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for GOT1:
|
Pathways & Interactions
for GOT1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | glutamate degradation II | | | 2 | Glucose metabolism | | | 3 | Sulfur amino acid metabolism | | | 4 | Metabolism | | | 5 | Tyrosine metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/8  BioSystems Pathways for GOT1 (see all 8)
5/9 
Reactome Pathways for GOT1 (see all 9)
1  PharmGKB Pathway for GOT1
5/7 
Kegg Pathways (Kegg details for GOT1) (see all 7):
GOT1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GOT1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/209 Interacting proteins for GOT1 (P171742, 3 ENSP000003595394) via UniProtKB, MINT, STRING, and/or I2D (see all 209)About this table
Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000096 | sulfur amino acid metabolic process |
TAS | -- | | GO:0005975 | carbohydrate metabolic process |
TAS | -- | | GO:0006006 | glucose metabolic process |
TAS | -- | | GO:0006094 | gluconeogenesis |
TAS | -- | | GO:0006103 | 2-oxoglutarate metabolic process |
ISS | -- |
GOT1 for ontologies About GeneDecksing
|
Drugs & Compounds
for GOT1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GOT1
10/18 HMDB Compounds for GOT1 (see all 18) About this table
5 DrugBank Compounds for GOT1 About this table
Search CenterWatch for drugs/clinical trials and news about GOT1 / AATC
|
Transcripts
for GOT1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GOT1 gene: NM_002079.2 Unigene Cluster for GOT1: Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) Hs.500756 [show with all ESTs]Unigene Representative Sequence: NM_0020794 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370508(uc001kpr.3 uc009xwi.2) ENST00000489349 ENST00000471741
ENST00000543866
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GOT1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GOT1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GOT1 (NM_002079) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GOT1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GOT1 |
Additional cDNA sequence: AF052153.1 AK293483.1 AK301916.1 AK309174.1 AK312684.1 AY513279.1 BC000498.2 M37400.1 18 DOTS entries: DT.95161440 DT.100880095 DT.450537 DT.100767584 DT.100880100 DT.121276203 DT.95161437 DT.100880101 DT.91766831 DT.91766816 DT.102823882 DT.121276217 DT.86843273 DT.91766828 DT.95161431 DT.97854688 DT.100743022 DT.101979725 24/584 AceView cDNA sequences (see all 584): AA284445 BG566332 BM833497 AI365638 CR619243 CF551943 AA579757 CR601723 BG431428 AI276814 BQ438905 BM968486 CF551810 H06362 BM857235 BU520808 CR620721 T85488 BX345172 BM459544 AI140172 BU623600 AW051465 BG110032
GeneLoc Exon Structure
|
Expression
for GOT1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GOT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACGGACACG
About this image
See GOT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GOT1
SOURCE GeneReport for Unigene cluster: Hs.500756
SABiosciences Expression via Pathway-Focused PCR Array including GOT1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GOT1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GOT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GOT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GOT1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOT1 |
Orthologs
for GOT1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for GOT1 gene from 11/38 species (see all 38) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Got11 , 5 |
glutamate oxaloacetate transaminase 1, soluble1, 5 |
87.09(n)1
90.8(a)1 |
|
19 (36.67 cM)5
147181 NM_010324.21 NP_034454.21
434997525 |
chicken
(Gallus gallus) |
Aves |
GOT11 |
glutamic-oxaloacetic transaminase 1, soluble (aspartate more |
76.12(n)
80.44(a) |
|
396261 NM_205321.1 NP_990652.1 |
lizard
(Anolis carolinensis) |
Reptilia |
GOT16 |
-- |
82(a) |
1 ↔ 1 |
3(38473854-38486439) |
African clawed frog
(Xenopus laevis) |
Amphibia |
xr406-prov2 |
Aspartate aminotransferase |
75.29(n) |
|
BC045269.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.282362 |
Danio rerio cDNA clone MGC55996 IMAGE3819704, complete more |
75.9(n) |
|
BC047800.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG84303
Got11 |
aspartate aminotransferase3
Glutamate oxaloacetate transaminase 11 |
56(a)3
59.1(n)1
56.86(a)1 |
|
367821 NM_166148.11 NP_725534.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
T01C8.53
got-1.21 |
aminotransferase3
Protein GOT-1.21 |
53(a)
(best of 3)3
58.5(n)1
54.46(a)1 |
|
X(16822325-16823912)3
1817261 NM_078308.41 NP_510709.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
AAT2(YLR027C)4
AAT21 |
Cytosolic aspartate aminotransferase, involved in nitrogen more4
Aat2p1 |
51.63(n)1
48.12(a)1 |
|
12(198085-196829)4
8507141, 4 NP_013127.21, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ASP31 |
aspartate aminotransferase |
55.61(n)
50.62(a) |
|
831024 NM_121190.2 NP_196713.1 |
rice
(Oryza sativa) |
Liliopsida |
Os01g07606001 |
hypothetical protein |
55.94(n)
51.35(a) |
|
4325621 NM_001050852.1 NP_001044317.1 |
ENSEMBL Gene Tree for GOT1 (if available)
TreeFam Gene Tree for GOT1 (if available) |
Paralogs
for GOT1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GOT1 gene
- GOT22 GOT1L12
3 SIMAP similar genes for GOT1 using alignment to 2 protein entries: AATC_HUMAN (see all proteins):GIG18 GOT2 GOT1L1
GOT1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for GOT1
PGOHUM00000249433
|
Genomic Variants
for GOT1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: AATC_HUMAN, P17174Polymorphism: Genetic variations in GOT1 are associated with low serum aspartate aminotransferase and define theaspartate aminotransferase serum level quantitative trait locus 1 (ASTQTL1) [MIM:614419]
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GOT1 (101156627 - 101190530 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GOT1: --
Human Gene Mutation Database (HGMD): GOT1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GOT1 |
|
Disorders
/ Diseases
for GOT1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GOT1 for disorders About GeneDecksing
OMIM gene information: 138180
OMIM disorders: --
20/34  diseases for GOT1 (see all 34): About MalaCardssevere acute respiratory syndrome type 2 diabetes mellitus substance abuse ochoa syndrome
glucose intolerance primary biliary cirrhosis myocardial infarction acute myocardial infarction
pyelonephritis reye syndrome acute pyelonephritis diabetes mellitus
insulin resistance hepatitis a osteopetrosis gallbladder disease
leukopenia myelodysplastic syndrome autoimmune hepatitis cholangitis
20/23 diseases from the University of Copenhagen DISEASES database for GOT1 (see all 23):Liver disease Fatty liver disease Hepatitis B Cholestasis
Hepatitis C Vascular disease Thrombocytopenia Hepatocellular carcinoma
Cholangitis Autoimmune hepatitis Bilirubin metabolic disorder Diarrhea
Hepatitis A Substance abuse Myocardial infarction Diabetes mellitus
Leukopenia Gallbladder disease Reye syndrome Myopathy
Human Genome Epidemiology (HuGE) Navigator: GOT1 (3 documents)
Export disorders for GOT1 gene to outside databases
|
Publications
for GOT1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GOT1 gene, integrated from 9 sources (see all 69):
(articles sorted by number of sources associating them with GOT1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Properties of human liver cytosolic aspartate aminotransferase mRNAs generated by alternative polyadenylation site selection. (PubMed id 1974457)1, 2, 3 Bousquet-Lemercier B.... Barouki R. (1990)
- Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels. (PubMed id 21900944)1, 2 Shen H.... Gong D.W. (2011)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The amino acid sequence of cytosolic aspartate aminotransferase from human liver. (PubMed id 2241899)1, 2 Doyle J.M.... Doonan S. (1990)
- Genetic homogeneity, high-resolution mapping, and mutation analysis of the urofacial (Ochoa) syndrome and exclusion of the glutamate oxaloacetate transaminase gene (GOT1) in the critical region as the disease gene. (PubMed id 10360399)1, 9 Wang C.Y....She J.X. (1999)
- Elevated aspartate and alanine aminotransferase levels and natural death among patients with methamphetamine dependence. (PubMed id 22242166)1 Kuo C.J....Chen W.J. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1 Kenny E.E....Peter I. (2012)
- Association of genetic polymorphism -670A>G in the Fas gene and serum markers AST platelet ratio index, AST/ALT with significant fi brosis and cirrhosis in chronic hepatitis C. (PubMed id 22352690)1 Deghady A....Diab I. (2012)
|
External Searches for GOT1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GOT1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GOT1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GOT1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GOT1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GOT1 gene:
Search GeneIP for patents involving GOT1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GOT1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for GOT1 | | OriGene shRNA RFP for GOT1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GOT1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GOT1 | | | OriGene Protein Over-expression Lysate for GOT1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GOT1 | | OriGene 3'-UTR Clone for GOT1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GOT1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GOT1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for GOT1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GOT1 | | OriGene Custom Protein Services for GOT1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GOT1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GOT1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GOT1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GOT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GOT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GOT1 |
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| | | | Search Tocris compounds for GOT1 |
| |  |  |  |  | | | | | | Recombinant Protein for GOT1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOT1 |
|  |  |  | | | | ThermoFisher Antibody for GOT1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GOT1 |
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