Free for academic non-profit institutions. Other users need a Commercial license

GOT1 Gene(Protein Coding)

Glutamic-Oxaloacetic Transaminase 1

GCID:
GC10M099396
GIFtS:
68
Genes Participants
UDN Logo

Aliases for GOT1 Gene

Aliases for GOT1 Gene

  • Glutamic-Oxaloacetic Transaminase 1 2 3
  • Glutamic-Oxaloacetic Transaminase 1, Soluble 2 3 5
  • Glutamate Oxaloacetate Transaminase 1 2 3 4
  • Cysteine Aminotransferase, Cytoplasmic 3 4
  • Cysteine Transaminase, Cytoplasmic 3 4
  • Aspartate Aminotransferase 1 2 3
  • Aspartate Transaminase 1 2 3
  • Transaminase A 3 4
  • EC 2.6.1.1 4 63
  • CAspAT 3 4
  • CCAT 3 4
  • Glutamic-Oxaloacetic Transaminase 1, Soluble (Aspartate Aminotransferase 1) 2
  • Testis Secretory Sperm-Binding Protein Li 196a 3
  • Growth-Inhibiting Protein 18 3
  • EC 2.6.1.3 4
  • ASTQTL1 3
  • GIG18 3
  • AST1 3

External Ids for GOT1 Gene

Previous GeneCards Identifiers for GOT1 Gene

  • GC10M100049
  • GC10M100390
  • GC10M101287
  • GC10M100821
  • GC10M101146
  • GC10M094783

Summaries for GOT1 Gene

Entrez Gene Summary for GOT1 Gene

  • Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]

GeneCards Summary for GOT1 Gene

GOT1 (Glutamic-Oxaloacetic Transaminase 1) is a Protein Coding gene. Diseases associated with GOT1 include Aspartate Aminotransferase, Serum Level Of, Qtl1 and Localized Pulmonary Fibrosis. Among its related pathways are Glycosaminoglycan metabolism and Tyrosine metabolism. GO annotations related to this gene include pyridoxal phosphate binding and carboxylic acid binding. An important paralog of this gene is GOT1L1.

UniProtKB/Swiss-Prot for GOT1 Gene

  • Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.

Gene Wiki entry for GOT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOT1 Gene

Genomics for GOT1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for GOT1 Gene

Enhancers for GOT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GOT1 on UCSC Golden Path with GeneCards custom track

Promoters for GOT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GOT1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the GOT1 gene promoter:

Genomic Location for GOT1 Gene

Chromosome:
10
Start:
99,396,870 bp from pter
End:
99,430,773 bp from pter
Size:
33,904 bases
Orientation:
Minus strand

Genomic View for GOT1 Gene

Genes around GOT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOT1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GOT1 Gene

Proteins for GOT1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GOT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17174-AATC_HUMAN
    Recommended name:
    Aspartate aminotransferase, cytoplasmic
    Protein Accession:
    P17174
    Secondary Accessions:
    • B2R6R7
    • B7Z7E9
    • Q5VW80

    Protein attributes for GOT1 Gene

    Size:
    413 amino acids
    Molecular mass:
    46248 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Aspartate aminotransferase activity found to be increased in cerebral spinal fluid (CSF) of patients with Alzheimer disease (PubMed:16039064). Fetal serum levels of the enzyme in the umbilical artery and vein are found to be significantly higher than maternal serum levels (PubMed:22633534).
    • In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

    Three dimensional structures from OCA and Proteopedia for GOT1 Gene

    Alternative splice isoforms for GOT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOT1 Gene

Proteomics data for GOT1 Gene at MOPED

Protein Expression for GOT1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for GOT1 Gene

P17174:

Post-translational modifications for GOT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GOT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for GOT1 Gene

Protein Domains for GOT1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GOT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17174

UniProtKB/Swiss-Prot:

AATC_HUMAN :
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Family:
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
genes like me logo Genes that share domains with GOT1: view

No data available for Gene Families for GOT1 Gene

Function for GOT1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for GOT1 Gene

GENATLAS Biochemistry:
glutamic-oxaloacetic transaminase 1,soluble (aspartate aminotransferase 1)
UniProtKB/Swiss-Prot CatalyticActivity:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
UniProtKB/Swiss-Prot CatalyticActivity:
L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate.
UniProtKB/Swiss-Prot Function:
Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.

Enzyme Numbers (IUBMB) for GOT1 Gene

Gene Ontology (GO) - Molecular Function for GOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IBA --
genes like me logo Genes that share ontologies with GOT1: view

Phenotypes for GOT1 Gene

GenomeRNAi human phenotypes for GOT1:
genes like me logo Genes that share phenotypes with GOT1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GOT1

miRNA for GOT1 Gene

miRTarBase miRNAs that target GOT1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOT1 Gene

Localization for GOT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOT1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GOT1 Gene COMPARTMENTS Subcellular localization image for GOT1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
lysosome 3
mitochondrion 3
vacuole 3
cytoskeleton 2
peroxisome 2
plasma membrane 2
chloroplast 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 7060339
genes like me logo Genes that share ontologies with GOT1: view

Pathways & Interactions for GOT1 Gene

genes like me logo Genes that share pathways with GOT1: view

Gene Ontology (GO) - Biological Process for GOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006107 oxaloacetate metabolic process IEA --
GO:0006114 glycerol biosynthetic process IEA,ISS --
GO:0006531 aspartate metabolic process IEA,ISS --
GO:0006532 aspartate biosynthetic process IEA,IBA --
GO:0006536 glutamate metabolic process ISS --
genes like me logo Genes that share ontologies with GOT1: view

No data available for SIGNOR curated interactions for GOT1 Gene

Drugs & Compounds for GOT1 Gene

Products:

  1. Drug

(11) Drugs for GOT1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Aspartic acid Approved Nutra Target NMDA agonist 0
L-Cysteine Approved Nutra Target 0
Famotidine Approved Pharma Histamine H2-receptor antagonist 57
L-Phenylalanine Approved Nutra 0
L-Tyrosine Approved Nutra 0

(11) Additional Compounds for GOT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Mercaptopyruvic acid
  • 3-Mercapto-pyruvate
  • 3-Mercapto-pyruvic acid
  • 3-Mercaptopyruvate
  • 3-Mercaptopyruvic acid
  • beta-3-Mercapto-2-oxo-propanoate
 2464-23-5
3-Sulfinylpyruvic acid
  • 3-Sulfinopyruvate
  • 3-Sulfinyl-pyruvate
  • 3-Sulfinylpyruvate
  • 3-Sulphinyl-pyruvate
  • beta-Sulfinylpyruvate
4-Hydroxy-2-oxoglutaric acid
  • (+/-)-2-hydroxy-4-oxopentanedioate
  • (+/-)-2-hydroxy-4-oxopentanedioic acid
  • 2-Hydroxy-4-oxopentanedioate
  • 2-Hydroxy-4-oxopentanedioic acid
  • 2-Keto-4-hydroxyglutarate
 1187-99-1
4-Hydroxy-L-glutamic acid
  • (2S)-2-amino-4-hydroxypentanedioate
  • (2S)-2-amino-4-hydroxypentanedioic acid
  • 4-Hydroxy-L-glutamate
  • 4-Hydroxy-L-glutamic acid
  • Erythro-4-hydroxyglutamate
 2485-33-8
4-Hydroxyphenylpyruvic acid
  • (p-hydroxyphenyl)-Pyruvate
  • (p-hydroxyphenyl)-Pyruvic acid
  • (p-Hydroxyphenyl)pyruvate
  • (p-Hydroxyphenyl)pyruvic acid
  • 3-(4-Hydroxyphenyl)-2-oxo-propanoate
 156-39-8
genes like me logo Genes that share compounds with GOT1: view

Transcripts for GOT1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for GOT1 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(584) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GOT1 Gene

Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOT1 Gene

No ASD Table

Relevant External Links for GOT1 Gene

GeneLoc Exon Structure for
GOT1
ECgene alternative splicing isoforms for
GOT1

Expression for GOT1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for GOT1 Gene

mRNA expression in normal human tissues for GOT1 Gene
mRNA expression by BioGPS for GOT1 GenemRNA expression by GTEx for GOT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GOT1 Gene

This gene is overexpressed in Heart - Left Ventricle (x7.8), Liver (x5.5), Muscle - Skeletal (x4.3), and Heart - Atrial Appendage (x4.3).

Protein differential expression in normal tissues from HIPED for GOT1 Gene

This gene is overexpressed in Liver, secretome (13.5), Heart (7.6), and Tonsil (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GOT1 Gene



SOURCE GeneReport for Unigene cluster for GOT1 Gene Hs.500756

genes like me logo Genes that share expression patterns with GOT1: view

Protein tissue co-expression partners for GOT1 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GOT1 Gene

Orthologs for GOT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GOT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia GOT1 35
  • 89.51 (n)
  • 91.53 (a)
GOT1 36
  • 92 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia GOT1 35
  • 89.43 (n)
  • 92.49 (a)
GOT1 36
  • 92 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Got1 35
  • 87.09 (n)
  • 90.8 (a)
Got1 16
Got1 36
  • 91 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia GOT1 35
  • 99.68 (n)
  • 99.76 (a)
GOT1 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Got1 35
  • 87.49 (n)
  • 90.31 (a)
oppossum
(Monodelphis domestica)
 Mammalia GOT1 36
  • 74 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia GOT1 36
  • 81 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves GOT1 35
  • 76.12 (n)
  • 80.44 (a)
GOT1 36
  • 80 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia GOT1 36
  • 81 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia got1 35
  • 73.43 (n)
  • 80.93 (a)
Str.556 35
African clawed frog
(Xenopus laevis)
 Amphibia xr406-prov 35
zebrafish
(Danio rerio)
 Actinopterygii Dr.28236 35
got1 35
  • 72.45 (n)
  • 77.02 (a)
got1 36
  • 77 (a)
 OneToOne
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.3656 35
fruit fly
(Drosophila melanogaster)
 Insecta CG8430 37
  • 56 (a)
Got1 35
  • 59.27 (n)
  • 57.11 (a)
Got1 36
  • 52 (a)
 OneToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP004142 35
  • 58.54 (n)
  • 61.19 (a)
worm
(Caenorhabditis elegans)
 Secernentea C14E2.2 37
  • 47 (a)
T01C8.4 37
  • 41 (a)
T01C8.5 37
  • 53 (a)
got-1.2 35
  • 58.5 (n)
  • 54.46 (a)
got-1.1 36
  • 51 (a)
 ManyToMany
got-1.2 36
  • 54 (a)
 ManyToMany
got-1.3 36
  • 37 (a)
 ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AFR211C 35
  • 51.88 (n)
  • 48.12 (a)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0F17754g 35
  • 50.86 (n)
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes AAT2 35
  • 51.8 (n)
  • 48.12 (a)
AAT2 36
  • 46 (a)
 OneToMany
AAT2 38
thale cress
(Arabidopsis thaliana)
 eudicotyledons ASP3 35
  • 55.61 (n)
  • 50.62 (a)
soybean
(Glycine max)
 eudicotyledons Gma.3139 35
rice
(Oryza sativa)
 Liliopsida Os01g0760600 35
  • 55.94 (n)
  • 51.35 (a)
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.5022 35
bread mold
(Neurospora crassa)
 Ascomycetes NCU07941 35
  • 54.59 (n)
  • 53.1 (a)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes SPAC10F6.13c 35
  • 51.03 (n)
  • 47.39 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.6560 36
  • 57 (a)
 OneToMany
Species with no ortholog for GOT1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GOT1 Gene

ENSEMBL:
Gene Tree for GOT1 (if available)
TreeFam:
Gene Tree for GOT1 (if available)

Paralogs for GOT1 Gene

Paralogs for GOT1 Gene

(3) SIMAP similar genes for GOT1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for GOT1 Gene

genes like me logo Genes that share paralogs with GOT1: view

Variants for GOT1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GOT1 Gene

AATC_HUMAN-P17174
Genetic variations in GOT1 are associated with low serum aspartate aminotransferase and define the aspartate aminotransferase serum level quantitative trait locus 1 (ASTQTL1) [MIM:614419].

Sequence variations from dbSNP and Humsavar for GOT1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2641 -- 99,397,002(+) ATGTA(C/T)GTGTC nc-transcript-variant, utr-variant-3-prime
rs2642 -- 99,396,992(+) TCAGT(C/T)AAATA nc-transcript-variant, utr-variant-3-prime
rs11867 -- 99,397,403(-) TAAAC(C/T)GGCCC nc-transcript-variant, utr-variant-3-prime
rs1802508 -- 99,397,139(-) GCTGC(A/G)GCATT nc-transcript-variant, utr-variant-3-prime
rs1802509 -- 99,397,280(-) ACATA(A/G/T)GTATC nc-transcript-variant, utr-variant-3-prime

Variation tolerance for GOT1 Gene

Residual Variation Intolerance Score: 35.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GOT1 Gene

Human Gene Mutation Database (HGMD)
GOT1

No data available for Structural Variations from Database of Genomic Variants (DGV) for GOT1 Gene

Disorders for GOT1 Gene

MalaCards: The human disease database

(47) MalaCards diseases for GOT1 Gene - From: OMIM, ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
aspartate aminotransferase, serum level of, qtl1
  • aspartate aminotransferase, serum level of, quantitative trait locus 1
localized pulmonary fibrosis
oculoglandular tularemia
cholecystitis
  • acute and chronic cholecystitis
glandular tularemia
- elite association - COSMIC cancer census association via MalaCards
Search GOT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GOT1

Genetic Association Database (GAD)
GOT1
Human Genome Epidemiology (HuGE) Navigator
GOT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GOT1
genes like me logo Genes that share disorders with GOT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GOT1 Gene

Publications for GOT1 Gene

  1. Properties of human liver cytosolic aspartate aminotransferase mRNAs generated by alternative polyadenylation site selection. (PMID: 1974457) Bousquet-Lemercier B. … Barouki R. (Biochemistry 1990) 2 3 4 67
  2. Effects of salvianolic acid a on oxidative stress and liver injury induced by carbon tetrachloride in rats. (PMID: 17244260) Wu Z.M. … Wu H. (Basic Clin. Pharmacol. Toxicol. 2007) 25 26
  3. Salivary thiols and enzyme markers of cell damage in periodontal disease. (PMID: 17328883) Zappacosta B. … De Sole P. (Clin. Biochem. 2007) 25 26
  4. Mitochondrial aspartate aminotransferase: a third kynurenate-producing enzyme in the mammalian brain. (PMID: 17442055) Guidetti P. … Schwarcz R. (J. Neurochem. 2007) 25 26
  5. The ketogenic diet and brain metabolism of amino acids: relationship to the anticonvulsant effect. (PMID: 17444813) Yudkoff M. … Nissim I. (Annu. Rev. Nutr. 2007) 25 26

Products for GOT1 Gene

  • Addgene plasmids for GOT1

Sources for GOT1 Gene

Content