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Aliases for GOSR1 Gene

Aliases for GOSR1 Gene

  • Golgi SNAP Receptor Complex Member 1 2 3 5
  • Golgi Integral Membrane Protein 2 2 3
  • 28 KDa Golgi SNARE Protein 3 4
  • 28 KDa Cis-Golgi SNARE P28 3 4
  • GOS-28 3 4
  • GS28 3 4
  • Golgi SNARE 28 KDa 3
  • Cis-Golgi SNARE 3
  • GOS28/P28 3
  • GOLIM2 3
  • GOS28 3
  • P28 3

External Ids for GOSR1 Gene

Previous GeneCards Identifiers for GOSR1 Gene

  • GC17P028557
  • GC17P030710
  • GC17P028950
  • GC17P025828
  • GC17P028804
  • GC17P025014

Summaries for GOSR1 Gene

Entrez Gene Summary for GOSR1 Gene

  • This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GOSR1 Gene

GOSR1 (Golgi SNAP Receptor Complex Member 1) is a Protein Coding gene. Diseases associated with GOSR1 include Chromosome 17Q11.2 Deletion Syndrome, 1.4-Mb. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. GO annotations related to this gene include SNAP receptor activity.

UniProtKB/Swiss-Prot for GOSR1 Gene

  • Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.

Gene Wiki entry for GOSR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOSR1 Gene

Genomics for GOSR1 Gene

Regulatory Elements for GOSR1 Gene

Enhancers for GOSR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F030506 0.9 ENCODE 11.6 +28.9 28876 0.2 BCOR ZBTB33 PRDM1 GOSR1 RNU6-1267P BLMH PIR40652 PIR40020
GH17F030476 0.5 ENCODE 8.8 +0.2 208 2.0 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 RNF135 ENSG00000264456 CORO6 CPD LRRC37BP1 BLMH RNU6-1267P GOSR1 LOC101927093 CRLF3
GH17F030449 0.7 ENCODE 8.5 -26.6 -26625 2.3 ATF1 MLX ARID4B YY1 SP5 MIER2 PPARG KAT8 MIER3 RCOR2 BLMH RNU6-1267P GOSR1 GC17P030463 GC17P030389
GH17F030376 1.1 ENCODE 8.2 -98.9 -98912 4.8 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 LRRC37BP1 SUZ12P1 ENSG00000265791 CORO6 TMIGD1 SMURF2P1 BLMH RNU6-1267P GOSR1 TBC1D29
GH17F030517 0.7 Ensembl ENCODE 8 +42.6 42619 4.1 BCOR SMARCA5 CTCF RFX1 JUN ZMYM3 CEBPB SIN3A RAD21 CBX1 BLMH RNU6-1267P CORO6 GOSR1 CPD RAB11FIP4 TBC1D29 PIR40652 PIR40020
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GOSR1 on UCSC Golden Path with GeneCards custom track

Promoters for GOSR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001343850 438 2001 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for GOSR1 Gene

Chromosome:
17
Start:
30,477,362 bp from pter
End:
30,527,592 bp from pter
Size:
50,231 bases
Orientation:
Plus strand

Genomic View for GOSR1 Gene

Genes around GOSR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOSR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOSR1 Gene

Proteins for GOSR1 Gene

  • Protein details for GOSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95249-GOSR1_HUMAN
    Recommended name:
    Golgi SNAP receptor complex member 1
    Protein Accession:
    O95249
    Secondary Accessions:
    • J3KST5
    • O75392

    Protein attributes for GOSR1 Gene

    Size:
    250 amino acids
    Molecular mass:
    28613 Da
    Quaternary structure:
    • Component of several multiprotein Golgi SNARE complexes. Identified in a SNARE complex with BET1, STX5 and YKT6, in a SNARE complex with BET1L, STX5 and YKT6, in a SNARE complex with STX5, GOSR2, SEC22B and BET1, and in complex with STX5 and COG3. Interacts with GABARAPL2 (By similarity).

    Alternative splice isoforms for GOSR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOSR1 Gene

Post-translational modifications for GOSR1 Gene

  • Ubiquitination at Lys 204
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GOSR1 Gene

Domains & Families for GOSR1 Gene

Gene Families for GOSR1 Gene

Protein Domains for GOSR1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O95249

UniProtKB/Swiss-Prot:

GOSR1_HUMAN :
  • Belongs to the GOSR1 family.
Family:
  • Belongs to the GOSR1 family.
genes like me logo Genes that share domains with GOSR1: view

Function for GOSR1 Gene

Molecular function for GOSR1 Gene

GENATLAS Biochemistry:
Golgi SNAP (soluble NSF (N-ethylmaleimide sensitive) attachment protein) receptor (SNARE) complex,member 1,trafficking membrane protein between the endoplastic reticulum and the Golgi subcompartments
UniProtKB/Swiss-Prot Function:
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
UniProtKB/Swiss-Prot Induction:
Expression induced by hydrogen peroxide in neuronal cells. By monocrotaline in pulmonary epithelial cells (at protein level). Negatively regulated by OSBPL7 via GABARAPL2 leading to degradation on proteasomes (at protein level).

Gene Ontology (GO) - Molecular Function for GOSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IDA 15215310
genes like me logo Genes that share ontologies with GOSR1: view
genes like me logo Genes that share phenotypes with GOSR1: view

Animal Model Products

miRNA for GOSR1 Gene

miRTarBase miRNAs that target GOSR1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOSR1 Gene

Localization for GOSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOSR1 Gene

Golgi apparatus membrane; Single-pass type IV membrane protein. Note=Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network (By similarity). Enriched on vesicular components at the terminal rims of the Golgi. Found in Golgi microtubules at low temperature (15 degrees Celsius). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GOSR1 Gene COMPARTMENTS Subcellular localization image for GOSR1 gene
Compartment Confidence
golgi apparatus 5
cytosol 2
endoplasmic reticulum 2
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GOSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA,IDA 9464276
GO:0005797 Golgi medial cisterna IBA --
GO:0005801 cis-Golgi network IEA,IBA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with GOSR1: view

Pathways & Interactions for GOSR1 Gene

genes like me logo Genes that share pathways with GOSR1: view

Pathways by source for GOSR1 Gene

Gene Ontology (GO) - Biological Process for GOSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport IEA,TAS --
GO:0006891 intra-Golgi vesicle-mediated transport TAS 8636227
GO:0006906 vesicle fusion IBA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with GOSR1: view

No data available for SIGNOR curated interactions for GOSR1 Gene

Transcripts for GOSR1 Gene

Unigene Clusters for GOSR1 Gene

Golgi SNAP receptor complex member 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOSR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2: -
SP3:

Relevant External Links for GOSR1 Gene

GeneLoc Exon Structure for
GOSR1
ECgene alternative splicing isoforms for
GOSR1

Expression for GOSR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GOSR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GOSR1 Gene

This gene is overexpressed in Nasal epithelium (55.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GOSR1 Gene



Protein tissue co-expression partners for GOSR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GOSR1 Gene:

GOSR1

SOURCE GeneReport for Unigene cluster for GOSR1 Gene:

Hs.462680
genes like me logo Genes that share expression patterns with GOSR1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GOSR1 Gene

Orthologs for GOSR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GOSR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOSR1 34 35
  • 99.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GOSR1 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GOSR1 34 35
  • 93.87 (n)
dog
(Canis familiaris)
Mammalia GOSR1 34 35
  • 93.73 (n)
oppossum
(Monodelphis domestica)
Mammalia GOSR1 35
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gosr1 34
  • 90.67 (n)
mouse
(Mus musculus)
Mammalia Gosr1 34 16 35
  • 89.6 (n)
chicken
(Gallus gallus)
Aves GOSR1 34 35
  • 83.4 (n)
lizard
(Anolis carolinensis)
Reptilia GOSR1 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gosr1 34
  • 80.93 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11947 34
zebrafish
(Danio rerio)
Actinopterygii gosr1 34 35
  • 73.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta Gos28 34 35
  • 55.51 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002454 34
  • 54.17 (n)
worm
(Caenorhabditis elegans)
Secernentea gos-28 34 35
  • 48.47 (n)
F08F8.8 36
  • 35 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E00639g 34
  • 42.36 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GOS1 34 35 37
  • 40.23 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL067C 34
  • 38.42 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons GOS12 34
  • 46.35 (n)
rice
(Oryza sativa)
Liliopsida Os02g0126800 34
  • 45.83 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9740 35
  • 64 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU02706 34
  • 40.74 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.572 34
Species where no ortholog for GOSR1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GOSR1 Gene

ENSEMBL:
Gene Tree for GOSR1 (if available)
TreeFam:
Gene Tree for GOSR1 (if available)

Paralogs for GOSR1 Gene

Pseudogenes.org Pseudogenes for GOSR1 Gene

genes like me logo Genes that share paralogs with GOSR1: view

No data available for Paralogs for GOSR1 Gene

Variants for GOSR1 Gene

Sequence variations from dbSNP and Humsavar for GOSR1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10512432 -- 30,485,102(+) TAAGC(A/G)TGTAC intron-variant
rs111240952 -- 30,508,110(+) AGGAT(A/G)AAGTT intron-variant
rs111283321 -- 30,488,611(+) TCACT(A/G)TAACC intron-variant
rs111286953 -- 30,501,126(+) CCGCC(C/G)GCCTC intron-variant
rs111468800 -- 30,518,100(+) CCTGG(A/G)AGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GOSR1 Gene

Variant ID Type Subtype PubMed ID
nsv1064611 CNV gain 25217958
nsv515870 CNV gain 19592680
nsv960082 CNV duplication 23825009

Variation tolerance for GOSR1 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GOSR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOSR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOSR1 Gene

Disorders for GOSR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GOSR1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 17q11.2 deletion syndrome, 1.4-mb
  • chromosome 17q11.2 deletion syndrome, 1.4mb
- elite association - COSMIC cancer census association via MalaCards
Search GOSR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GOSR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GOSR1
genes like me logo Genes that share disorders with GOSR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GOSR1 Gene

Publications for GOSR1 Gene

  1. The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. (PMID: 15004235) Oka T. … Krieger M. (Mol. Biol. Cell 2004) 2 3 22 64
  2. Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network. (PMID: 15215310) Tai G. … Hong W. (Mol. Biol. Cell 2004) 3 4 22 64
  3. cDNA characterization and chromosomal mapping of human Golgi SNARE GS27 and GS28 to chromosome 17. (PMID: 10198168) Bui T.D. … Hong W. (Genomics 1999) 3 4 22 64
  4. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 64
  5. GS28, a 28-kilodalton Golgi SNARE that participates in ER-Golgi transport. (PMID: 8638159) Subramaniam V.N. … Hong W. (Science 1996) 2 3 22 64

Products for GOSR1 Gene

Sources for GOSR1 Gene

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