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Aliases for GOSR1 Gene

Aliases for GOSR1 Gene

  • Golgi SNAP Receptor Complex Member 1 2 3
  • Golgi Integral Membrane Protein 2 2 3
  • 28 KDa Golgi SNARE Protein 3 4
  • 28 KDa Cis-Golgi SNARE P28 3 4
  • GOS-28 3 4
  • GS28 3 4
  • Golgi SNARE 28 KDa 3
  • Cis-Golgi SNARE 3
  • GOS28/P28 3
  • GOLIM2 3
  • GOS28 3
  • P28 3

External Ids for GOSR1 Gene

Previous GeneCards Identifiers for GOSR1 Gene

  • GC17P028557
  • GC17P030710
  • GC17P028950
  • GC17P025828
  • GC17P028804
  • GC17P025014

Summaries for GOSR1 Gene

Entrez Gene Summary for GOSR1 Gene

  • This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GOSR1 Gene

GOSR1 (Golgi SNAP Receptor Complex Member 1) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF). GO annotations related to this gene include SNAP receptor activity.

UniProtKB/Swiss-Prot for GOSR1 Gene

  • Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.

Gene Wiki entry for GOSR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOSR1 Gene

Genomics for GOSR1 Gene

Regulatory Elements for GOSR1 Gene

Genomic Location for GOSR1 Gene

Chromosome:
17
Start:
30,477,362 bp from pter
End:
30,527,592 bp from pter
Size:
50,231 bases
Orientation:
Plus strand

Genomic View for GOSR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GOSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOSR1 Gene

Proteins for GOSR1 Gene

  • Protein details for GOSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95249-GOSR1_HUMAN
    Recommended name:
    Golgi SNAP receptor complex member 1
    Protein Accession:
    O95249
    Secondary Accessions:
    • J3KST5
    • O75392

    Protein attributes for GOSR1 Gene

    Size:
    250 amino acids
    Molecular mass:
    28613 Da
    Quaternary structure:
    • Component of several multiprotein Golgi SNARE complexes. Identified in a SNARE complex with BET1, STX5 and YKT6, in a SNARE complex with BET1L, STX5 and YKT6, in a SNARE complex with STX5, GOSR2, SEC22B and BET1, and in complex with STX5 and COG3. Interacts with GABARAPL2 (By similarity).

    Alternative splice isoforms for GOSR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOSR1 Gene

Proteomics data for GOSR1 Gene at MOPED

Post-translational modifications for GOSR1 Gene

  • Ubiquitination at Lys 204
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for GOSR1 Gene

Domains & Families for GOSR1 Gene

Protein Domains for GOSR1 Gene

Blocks:
InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O95249

UniProtKB/Swiss-Prot:

GOSR1_HUMAN :
  • Belongs to the GOSR1 family.
Family:
  • Belongs to the GOSR1 family.
genes like me logo Genes that share domains with GOSR1: view

No data available for Gene Families for GOSR1 Gene

Function for GOSR1 Gene

Molecular function for GOSR1 Gene

GENATLAS Biochemistry:
Golgi SNAP (soluble NSF (N-ethylmaleimide sensitive) attachment protein) receptor (SNARE) complex,member 1,trafficking membrane protein between the endoplastic reticulum and the Golgi subcompartments
UniProtKB/Swiss-Prot Function:
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
UniProtKB/Swiss-Prot Induction:
Expression induced by hydrogen peroxide in neuronal cells. By monocrotaline in pulmonary epithelial cells (at protein level). Negatively regulated by OSBPL7 via GABARAPL2 leading to degradation on proteasomes (at protein level).

Gene Ontology (GO) - Molecular Function for GOSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IDA 15215310
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with GOSR1: view

Phenotypes for GOSR1 Gene

genes like me logo Genes that share phenotypes with GOSR1: view

Animal Model Products

CRISPR Products

miRNA for GOSR1 Gene

miRTarBase miRNAs that target GOSR1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GOSR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GOSR1 Gene

Localization for GOSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOSR1 Gene

Golgi apparatus membrane; Single-pass type IV membrane protein. Note=Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network (By similarity). Enriched on vesicular components at the terminal rims of the Golgi. Found in Golgi microtubules at low temperature (15 degrees Celsius). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GOSR1 Gene COMPARTMENTS Subcellular localization image for GOSR1 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for GOSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 21669198
GO:0005794 Golgi apparatus IDA 9464276
GO:0005797 Golgi medial cisterna IBA --
GO:0005801 cis-Golgi network IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with GOSR1: view

Pathways & Interactions for GOSR1 Gene

genes like me logo Genes that share pathways with GOSR1: view

Pathways by source for GOSR1 Gene

1 Qiagen pathway for GOSR1 Gene
1 KEGG pathway for GOSR1 Gene
1 GeneGo (Thomson Reuters) pathway for GOSR1 Gene

Gene Ontology (GO) - Biological Process for GOSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
GO:0006891 intra-Golgi vesicle-mediated transport TAS 8636227
GO:0006906 vesicle fusion IBA --
GO:0015031 protein transport IEA --
GO:0042147 retrograde transport, endosome to Golgi IDA 15215310
genes like me logo Genes that share ontologies with GOSR1: view

No data available for SIGNOR curated interactions for GOSR1 Gene

Drugs & Compounds for GOSR1 Gene

No Compound Related Data Available

Transcripts for GOSR1 Gene

Unigene Clusters for GOSR1 Gene

Golgi SNAP receptor complex member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GOSR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOSR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2: -
SP3:

Relevant External Links for GOSR1 Gene

GeneLoc Exon Structure for
GOSR1
ECgene alternative splicing isoforms for
GOSR1

Expression for GOSR1 Gene

mRNA expression in normal human tissues for GOSR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GOSR1 Gene

This gene is overexpressed in Nasal epithelium (55.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GOSR1 Gene



SOURCE GeneReport for Unigene cluster for GOSR1 Gene Hs.462680

genes like me logo Genes that share expression patterns with GOSR1: view

Protein tissue co-expression partners for GOSR1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GOSR1 Gene

Orthologs for GOSR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GOSR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GOSR1 35
  • 93.87 (n)
  • 97.2 (a)
GOSR1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GOSR1 35
  • 93.73 (n)
  • 98 (a)
GOSR1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gosr1 35
  • 89.6 (n)
  • 97.6 (a)
Gosr1 16
Gosr1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GOSR1 35
  • 99.73 (n)
  • 99.6 (a)
GOSR1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gosr1 35
  • 90.67 (n)
  • 98.4 (a)
oppossum
(Monodelphis domestica)
Mammalia GOSR1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GOSR1 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves GOSR1 35
  • 83.4 (n)
  • 93.42 (a)
GOSR1 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GOSR1 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gosr1 35
  • 80.93 (n)
  • 90 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11947 35
zebrafish
(Danio rerio)
Actinopterygii gosr1 35
  • 73.67 (n)
  • 87.82 (a)
gosr1 36
  • 86 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002454 35
  • 54.17 (n)
  • 53.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gos28 35
  • 55.51 (n)
  • 50.43 (a)
Gos28 36
  • 48 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F08F8.8 37
  • 35 (a)
gos-28 35
  • 48.47 (n)
  • 38.86 (a)
gos-28 36
  • 37 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL067C 35
  • 38.42 (n)
  • 25.79 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E00639g 35
  • 42.36 (n)
  • 29.86 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GOS1 35
  • 40.23 (n)
  • 28.16 (a)
GOS1 36
  • 26 (a)
OneToOne
GOS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons GOS12 35
  • 46.35 (n)
  • 36.05 (a)
rice
(Oryza sativa)
Liliopsida Os02g0126800 35
  • 45.83 (n)
  • 36.16 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.572 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02706 35
  • 40.74 (n)
  • 31.56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9740 36
  • 64 (a)
OneToOne
Species with no ortholog for GOSR1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GOSR1 Gene

ENSEMBL:
Gene Tree for GOSR1 (if available)
TreeFam:
Gene Tree for GOSR1 (if available)

Paralogs for GOSR1 Gene

Pseudogenes.org Pseudogenes for GOSR1 Gene

genes like me logo Genes that share paralogs with GOSR1: view

No data available for Paralogs for GOSR1 Gene

Variants for GOSR1 Gene

Sequence variations from dbSNP and Humsavar for GOSR1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs216463 -- 30,526,512(+) AGCTC(A/C)CTTTA utr-variant-3-prime
rs726663 -- 30,518,756(+) AGACC(C/T)CATCT intron-variant
rs726664 -- 30,518,701(+) AGGTA(A/G)GAGGA intron-variant
rs917630 -- 30,502,614(+) CTCCC(A/G)GTAAC intron-variant
rs1434688 -- 30,513,379(+) ATTAT(A/G)TATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GOSR1 Gene

Variant ID Type Subtype PubMed ID
nsv908044 CNV Gain 21882294
nsv515870 CNV Gain 19592680

Variation tolerance for GOSR1 Gene

Residual Variation Intolerance Score: 25.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GOSR1 Gene

HapMap Linkage Disequilibrium report
GOSR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOSR1 Gene

Disorders for GOSR1 Gene

Relevant External Links for GOSR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GOSR1
genes like me logo Genes that share disorders with GOSR1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOSR1 Gene

Publications for GOSR1 Gene

  1. The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. (PMID: 15004235) Oka T. … Krieger M. (Mol. Biol. Cell 2004) 2 23 67
  2. GS28, a 28-kilodalton Golgi SNARE that participates in ER-Golgi transport. (PMID: 8638159) Subramaniam V.N. … Hong W. (Science 1996) 2 23 67
  3. Low-temperature-induced Golgi tubules are transient membranes enriched in molecules regulating intra-Golgi transport. (PMID: 17274796) Martinez-Alonso E. … Martinez-Menarguez J.A. (Traffic 2007) 23 67
  4. COG-7-deficient Human Fibroblasts Exhibit Altered Recycling of Golgi Proteins. (PMID: 16510524) Steet R. … Kornfeld S. (Mol. Biol. Cell 2006) 23 67
  5. Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network. (PMID: 15215310) Tai G. … Hong W. (Mol. Biol. Cell 2004) 23 67

Products for GOSR1 Gene

Sources for GOSR1 Gene

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