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Aliases for GORASP2 Gene

Aliases for GORASP2 Gene

  • Golgi Reassembly Stacking Protein 2 2 3 5
  • Golgi Reassembly Stacking Protein 2, 55kDa 2 3
  • Golgi Phosphoprotein 6 3 4
  • GRASP55 3 4
  • GOLPH6 3 4
  • GRS2 3 4
  • P59 3 4
  • Golgi Reassembly Stacking Protein 2, 55 KDa 2
  • Golgi Reassembly-Stacking Protein Of 55 KDa 4
  • Golgi Reassembly-Stacking Protein 2 3

External Ids for GORASP2 Gene

Previous GeneCards Identifiers for GORASP2 Gene

  • GC02P169837
  • GC02P170326
  • GC02P171749
  • GC02P171988
  • GC02P171986
  • GC02P171611
  • GC02P171493
  • GC02P163674
  • GC02P171784

Summaries for GORASP2 Gene

Entrez Gene Summary for GORASP2 Gene

  • This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for GORASP2 Gene

GORASP2 (Golgi Reassembly Stacking Protein 2) is a Protein Coding gene. Among its related pathways are Mitotic Prophase and Cell Cycle, Mitotic. An important paralog of this gene is GORASP1.

UniProtKB/Swiss-Prot for GORASP2 Gene

  • Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after mitotic breakdown. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA.

Gene Wiki entry for GORASP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GORASP2 Gene

Genomics for GORASP2 Gene

Regulatory Elements for GORASP2 Gene

Enhancers for GORASP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G170501 2.1 Ensembl ENCODE 19.6 -424.1 -424101 4.8 FOXA2 ZFP64 GATA2 FOS ZNF202 ZNF680 ZNF654 ZBTB11 OVOL3 ZNF426 DCAF17 DAP3P2 GORASP2 PHOSPHO2 EIF2S2P4 LOC101929753 SP5 MYO3B GC02P170510 GC02P170458
GH02G170820 0.8 ENCODE 19.7 -108.1 -108113 0.2 RING1 SUZ12 ZFP64 ZNF140 MAX ZNF101 ZNF697 EZH2 ZNF680 RNF2 DCAF17 DAP3P2 GORASP2 GAD1 EIF2S2P4 RPS15P4 ENSG00000235934 GC02M170820
GH02G171260 1.4 FANTOM5 Ensembl ENCODE 10.5 +332.8 332845 2.5 ELF3 FOXA2 RAD21 DNMT3B RARA ZNF766 CBX5 RELB IKZF2 THAP11 TLK1 DAP3P2 HAT1 GORASP2 EIF2S2P4 GC02M171274
GH02G170927 1.8 FANTOM5 ENCODE dbSUPER 7.2 +1.1 1077 3.8 MLX CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 DAP3P2 RPS15P4 GORASP2 TLK1 GC02M170927 GC02P170969
GH02G171158 1.4 ENCODE dbSUPER 5.6 +231.9 231874 4.4 HDGF PKNOX1 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 HAT1 GORASP2 GC02P171119 GC02P171227
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GORASP2 on UCSC Golden Path with GeneCards custom track

Promoters for GORASP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000126146 1362 2401 MLX CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21

Genomic Location for GORASP2 Gene

Chromosome:
2
Start:
170,928,438 bp from pter
End:
170,967,135 bp from pter
Size:
38,698 bases
Orientation:
Plus strand

Genomic View for GORASP2 Gene

Genes around GORASP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GORASP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GORASP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GORASP2 Gene

Proteins for GORASP2 Gene

  • Protein details for GORASP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8Y8-GORS2_HUMAN
    Recommended name:
    Golgi reassembly-stacking protein 2
    Protein Accession:
    Q9H8Y8
    Secondary Accessions:
    • B4DKT0
    • Q53TE3
    • Q96I74
    • Q96K84
    • Q9H946
    • Q9UFW4

    Protein attributes for GORASP2 Gene

    Size:
    452 amino acids
    Molecular mass:
    47145 Da
    Quaternary structure:
    • Forms a RAB2 effector complex with BLZF1/Golgin 45 in the medial Golgi. Interacts with members of the p24 cargo receptors. Interacts with CNIH and the cytoplasmic domain of transmembrane TGFA, prior its transit in the trans-Golgi. Does not interact with GM130. Interacts with KCTD5. Interacts with TMED2 and TMED3 (By similarity).

    Three dimensional structures from OCA and Proteopedia for GORASP2 Gene

    Alternative splice isoforms for GORASP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GORASP2 Gene

Post-translational modifications for GORASP2 Gene

Other Protein References for GORASP2 Gene

No data available for DME Specific Peptides for GORASP2 Gene

Domains & Families for GORASP2 Gene

Gene Families for GORASP2 Gene

Protein Domains for GORASP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H8Y8

UniProtKB/Swiss-Prot:

GORS2_HUMAN :
  • Belongs to the GORASP family.
Family:
  • Belongs to the GORASP family.
genes like me logo Genes that share domains with GORASP2: view

Function for GORASP2 Gene

Molecular function for GORASP2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after mitotic breakdown. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA.

Gene Ontology (GO) - Molecular Function for GORASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with GORASP2: view
genes like me logo Genes that share phenotypes with GORASP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GORASP2 Gene

Localization for GORASP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GORASP2 Gene

Golgi apparatus membrane; Lipid-anchor. Membrane; Peripheral membrane protein. Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GORASP2 gene
Compartment Confidence
golgi apparatus 5
nucleus 2
cytosol 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GORASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IDA --
GO:0016020 membrane TAS 21515684
genes like me logo Genes that share ontologies with GORASP2: view

Pathways & Interactions for GORASP2 Gene

genes like me logo Genes that share pathways with GORASP2: view

Pathways by source for GORASP2 Gene

Gene Ontology (GO) - Biological Process for GORASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization IMP 21515684
GO:0007030 Golgi organization IBA --
genes like me logo Genes that share ontologies with GORASP2: view

No data available for SIGNOR curated interactions for GORASP2 Gene

Drugs & Compounds for GORASP2 Gene

No Compound Related Data Available

Transcripts for GORASP2 Gene

Unigene Clusters for GORASP2 Gene

Golgi reassembly stacking protein 2, 55kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GORASP2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ·
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - -
SP5:
SP6: - - - -
SP7: - - -
SP8: - - - - - - - -
SP9: - -
SP10: -
SP11: - - -

ExUns: 12c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for GORASP2 Gene

GeneLoc Exon Structure for
GORASP2
ECgene alternative splicing isoforms for
GORASP2

Expression for GORASP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GORASP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GORASP2 Gene

This gene is overexpressed in Nasal epithelium (9.0) and Bone marrow stromal cell (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GORASP2 Gene



Protein tissue co-expression partners for GORASP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GORASP2 Gene:

GORASP2

SOURCE GeneReport for Unigene cluster for GORASP2 Gene:

Hs.431317

Evidence on tissue expression from TISSUES for GORASP2 Gene

  • Nervous system(4.8)
  • Liver(4.5)
  • Intestine(3.8)
  • Lung(3.3)
  • Skin(3.3)
  • Kidney(2.6)
  • Eye(2)
genes like me logo Genes that share expression patterns with GORASP2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GORASP2 Gene

Orthologs for GORASP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GORASP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GORASP2 34 35
  • 99.48 (n)
cow
(Bos Taurus)
Mammalia GORASP2 34 35
  • 89.82 (n)
dog
(Canis familiaris)
Mammalia GORASP2 34 35
  • 89.75 (n)
mouse
(Mus musculus)
Mammalia Gorasp2 34 16 35
  • 86.22 (n)
rat
(Rattus norvegicus)
Mammalia Gorasp2 34
  • 85.15 (n)
oppossum
(Monodelphis domestica)
Mammalia GORASP2 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GORASP2 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves GORASP2 34 35
  • 75 (n)
lizard
(Anolis carolinensis)
Reptilia GORASP2 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gorasp2 34
  • 70.02 (n)
Str.6119 34
African clawed frog
(Xenopus laevis)
Amphibia gorasp2-prov 34
zebrafish
(Danio rerio)
Actinopterygii gorasp2 34 35
  • 65.32 (n)
zgc73072 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5695 34
fruit fly
(Drosophila melanogaster)
Insecta CG7809 36
  • 71 (a)
Grasp65 35
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y42H9AR.1 36 35
  • 56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GRH1 35
  • 21 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1147 34
Species where no ortholog for GORASP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GORASP2 Gene

ENSEMBL:
Gene Tree for GORASP2 (if available)
TreeFam:
Gene Tree for GORASP2 (if available)

Paralogs for GORASP2 Gene

Paralogs for GORASP2 Gene

(1) SIMAP similar genes for GORASP2 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for GORASP2 Gene

genes like me logo Genes that share paralogs with GORASP2: view

Variants for GORASP2 Gene

Sequence variations from dbSNP and Humsavar for GORASP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000094863 -- 170,958,064(+) ATGCA(A/G)TAGTA intron-variant
rs1000097663 -- 170,959,802(+) TTTCT(-/GCAGTGTA)GCAGT intron-variant
rs1000157002 -- 170,933,331(+) TGTAA(G/T)TTACC intron-variant
rs1000250333 -- 170,942,419(+) ATCTG(C/G)TTTCT intron-variant
rs1000364470 -- 170,964,073(+) AGATA(C/T)TCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GORASP2 Gene

Variant ID Type Subtype PubMed ID
esv3593343 CNV gain 21293372

Variation tolerance for GORASP2 Gene

Residual Variation Intolerance Score: 20.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.70; 66.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GORASP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GORASP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GORASP2 Gene

Disorders for GORASP2 Gene

Relevant External Links for GORASP2

Genetic Association Database (GAD)
GORASP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GORASP2

No disorders were found for GORASP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GORASP2 Gene

Publications for GORASP2 Gene

  1. GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system. (PMID: 10487747) Shorter J. … Barr F.A. (EMBO J. 1999) 2 3 4 64
  2. Structure of the membrane-tethering GRASP domain reveals a unique PDZ ligand interaction that mediates Golgi biogenesis. (PMID: 21515684) Truschel S.T. … Linstedt A.D. (J. Biol. Chem. 2011) 3 4 64
  3. GRASP55 and GRASP65 play complementary and essential roles in Golgi cisternal stacking. (PMID: 20083603) Xiang Y. … Wang Y. (J. Cell Biol. 2010) 3 22 64
  4. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need A.C. … Goldstein D.B. (Hum. Mol. Genet. 2009) 3 46 64
  5. GRASP65 and GRASP55 sequentially promote the transport of C-terminal valine-bearing cargos to and through the Golgi complex. (PMID: 19840934) D'Angelo G. … Bonatti S. (J. Biol. Chem. 2009) 3 22 64

Products for GORASP2 Gene

Sources for GORASP2 Gene

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