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Aliases for GORASP2 Gene

Aliases for GORASP2 Gene

  • Golgi Reassembly Stacking Protein 2, 55kDa 2 3
  • Golgi Phosphoprotein 6 3 4
  • GRASP55 3 4
  • GOLPH6 3 4
  • GRS2 3 4
  • P59 3 4
  • Golgi Reassembly Stacking Protein 2, 55 KDa 2
  • Golgi Reassembly-Stacking Protein Of 55 KDa 4

External Ids for GORASP2 Gene

Previous GeneCards Identifiers for GORASP2 Gene

  • GC02P169837
  • GC02P170326
  • GC02P171749
  • GC02P171988
  • GC02P171986
  • GC02P171611
  • GC02P171493
  • GC02P163674
  • GC02P171784

Summaries for GORASP2 Gene

Entrez Gene Summary for GORASP2 Gene

  • This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for GORASP2 Gene

GORASP2 (Golgi Reassembly Stacking Protein 2, 55kDa) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Mitotic Prophase. An important paralog of this gene is GORASP1.

UniProtKB/Swiss-Prot for GORASP2 Gene

  • Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after mitotic breakdown. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA.

Gene Wiki entry for GORASP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GORASP2 Gene

Genomics for GORASP2 Gene

Regulatory Elements for GORASP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GORASP2 Gene

Chromosome:
2
Start:
170,928,438 bp from pter
End:
170,967,135 bp from pter
Size:
38,698 bases
Orientation:
Plus strand

Genomic View for GORASP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GORASP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GORASP2 Gene

Proteins for GORASP2 Gene

  • Protein details for GORASP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8Y8-GORS2_HUMAN
    Recommended name:
    Golgi reassembly-stacking protein 2
    Protein Accession:
    Q9H8Y8
    Secondary Accessions:
    • B4DKT0
    • Q53TE3
    • Q96I74
    • Q96K84
    • Q9H946
    • Q9UFW4

    Protein attributes for GORASP2 Gene

    Size:
    452 amino acids
    Molecular mass:
    47145 Da
    Quaternary structure:
    • Forms a RAB2 effector complex with BLZF1/Golgin 45 in the medial Golgi. Interacts with members of the p24 cargo receptors. Interacts with CNIH and the cytoplasmic domain of transmembrane TGFA, prior its transit in the trans-Golgi. Does not interact with GM130. Interacts with KCTD5. Interacts with TMED2 and TMED3 (By similarity).

    Three dimensional structures from OCA and Proteopedia for GORASP2 Gene

    Alternative splice isoforms for GORASP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GORASP2 Gene

Proteomics data for GORASP2 Gene at MOPED

Post-translational modifications for GORASP2 Gene

Other Protein References for GORASP2 Gene

Antibody Products

No data available for DME Specific Peptides for GORASP2 Gene

Domains & Families for GORASP2 Gene

Protein Domains for GORASP2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H8Y8

UniProtKB/Swiss-Prot:

GORS2_HUMAN :
  • Contains 1 PDZ (DHR) domain.
  • Belongs to the GORASP family.
Domain:
  • Contains 1 PDZ (DHR) domain.
Family:
  • Belongs to the GORASP family.
genes like me logo Genes that share domains with GORASP2: view

No data available for Gene Families for GORASP2 Gene

Function for GORASP2 Gene

Molecular function for GORASP2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after mitotic breakdown. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA.

Gene Ontology (GO) - Molecular Function for GORASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with GORASP2: view
genes like me logo Genes that share phenotypes with GORASP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GORASP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GORASP2 Gene

Localization for GORASP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GORASP2 Gene

Golgi apparatus membrane; Lipid-anchor. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GORASP2 Gene COMPARTMENTS Subcellular localization image for GORASP2 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GORASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IDA --
GO:0016020 membrane TAS 21515684
genes like me logo Genes that share ontologies with GORASP2: view

Pathways & Interactions for GORASP2 Gene

genes like me logo Genes that share pathways with GORASP2: view

Pathways by source for GORASP2 Gene

Gene Ontology (GO) - Biological Process for GORASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006996 organelle organization IMP 21515684
genes like me logo Genes that share ontologies with GORASP2: view

No data available for SIGNOR curated interactions for GORASP2 Gene

Drugs & Compounds for GORASP2 Gene

No Compound Related Data Available

Transcripts for GORASP2 Gene

Unigene Clusters for GORASP2 Gene

Golgi reassembly stacking protein 2, 55kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GORASP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GORASP2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ·
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - -
SP5:
SP6: - - - -
SP7: - - -
SP8: - - - - - - - -
SP9: - -
SP10: -
SP11: - - -

ExUns: 12c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for GORASP2 Gene

GeneLoc Exon Structure for
GORASP2
ECgene alternative splicing isoforms for
GORASP2

Expression for GORASP2 Gene

mRNA expression in normal human tissues for GORASP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GORASP2 Gene

This gene is overexpressed in Nasal epithelium (9.0) and Bone marrow stromal cell (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GORASP2 Gene



SOURCE GeneReport for Unigene cluster for GORASP2 Gene Hs.431317

genes like me logo Genes that share expression patterns with GORASP2: view

Protein tissue co-expression partners for GORASP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GORASP2 Gene

Orthologs for GORASP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GORASP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GORASP2 35
  • 89.82 (n)
  • 90.49 (a)
GORASP2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GORASP2 35
  • 89.75 (n)
  • 91.15 (a)
GORASP2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gorasp2 35
  • 86.22 (n)
  • 89.89 (a)
Gorasp2 16
Gorasp2 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GORASP2 35
  • 99.48 (n)
  • 99.56 (a)
GORASP2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gorasp2 35
  • 85.15 (n)
  • 88.64 (a)
oppossum
(Monodelphis domestica)
Mammalia GORASP2 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GORASP2 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves GORASP2 35
  • 75 (n)
  • 77.73 (a)
GORASP2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GORASP2 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gorasp2 35
  • 70.02 (n)
  • 73.62 (a)
Str.6119 35
African clawed frog
(Xenopus laevis)
Amphibia gorasp2-prov 35
zebrafish
(Danio rerio)
Actinopterygii gorasp2 35
  • 65.32 (n)
  • 72.62 (a)
zgc73072 35
gorasp2 36
  • 66 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5695 35
fruit fly
(Drosophila melanogaster)
Insecta CG7809 37
  • 71 (a)
Grasp65 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y42H9AR.1 37
  • 56 (a)
Y42H9AR.1 36
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GRH1 36
  • 21 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1147 35
Species with no ortholog for GORASP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GORASP2 Gene

ENSEMBL:
Gene Tree for GORASP2 (if available)
TreeFam:
Gene Tree for GORASP2 (if available)

Paralogs for GORASP2 Gene

Paralogs for GORASP2 Gene

(1) SIMAP similar genes for GORASP2 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for GORASP2 Gene

genes like me logo Genes that share paralogs with GORASP2: view

Variants for GORASP2 Gene

Sequence variations from dbSNP and Humsavar for GORASP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs731692 -- 170,940,679(+) CAGAA(A/G)TATTA intron-variant
rs731693 -- 170,940,724(+) TTTTT(A/G)TTGTA intron-variant
rs966181 -- 170,939,745(-) GTCCC(C/T)GTTAT intron-variant
rs1035839 -- 170,952,975(-) AATTC(A/G)GCCAG intron-variant
rs1043639 -- 170,966,784(+) CATAC(A/C)CCTTA utr-variant-3-prime

Variation tolerance for GORASP2 Gene

Residual Variation Intolerance Score: 20.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.70; 66.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GORASP2 Gene

HapMap Linkage Disequilibrium report
GORASP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GORASP2 Gene

Disorders for GORASP2 Gene

Relevant External Links for GORASP2

Genetic Association Database (GAD)
GORASP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GORASP2
genes like me logo Genes that share disorders with GORASP2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GORASP2 Gene

Publications for GORASP2 Gene

  1. GRASP55 and GRASP65 play complementary and essential roles in Golgi cisternal stacking. (PMID: 20083603) Xiang Y. … Wang Y. (J. Cell Biol. 2010) 23 67
  2. GRASP65 and GRASP55 sequentially promote the transport of C-terminal valine-bearing cargos to and through the Golgi complex. (PMID: 19840934) D'Angelo G. … Bonatti S. (J. Biol. Chem. 2009) 23 67
  3. GRASP55 regulates Golgi ribbon formation. (PMID: 18434598) Feinstein T.N. … Linstedt A.D. (Mol. Biol. Cell 2008) 23 67
  4. Dynamics of Golgi matrix proteins after the blockage of ER to Golgi transport. (PMID: 15047722) Yoshimura S. … Nakamura N. (J. Biochem. 2004) 23 67
  5. GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system. (PMID: 10487747) Shorter J. … Barr F.A. (EMBO J. 1999) 2 67

Products for GORASP2 Gene

Sources for GORASP2 Gene

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