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Aliases for GORASP1 Gene

Aliases for GORASP1 Gene

  • Golgi Reassembly Stacking Protein 1 2 3 5
  • Golgi Phosphoprotein 5 2 3 4
  • Golgi Reassembly-Stacking Protein Of 65 KDa 3 4
  • Golgi Reassembly Stacking Protein 1, 65kDa 2 3
  • Golgi Peripheral Membrane Protein P65 3 4
  • GRASP65 3 4
  • GOLPH5 3 4
  • Golgi Reassembly And Stacking Protein 1 3
  • P65 3

External Ids for GORASP1 Gene

Previous HGNC Symbols for GORASP1 Gene

  • GOLPH5

Previous GeneCards Identifiers for GORASP1 Gene

  • GC03M038478
  • GC03P038045
  • GC03M038951
  • GC03M039098

Summaries for GORASP1 Gene

Entrez Gene Summary for GORASP1 Gene

  • The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for GORASP1 Gene

GORASP1 (Golgi Reassembly Stacking Protein 1) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Mitotic Prophase. An important paralog of this gene is GORASP2.

UniProtKB/Swiss-Prot for GORASP1 Gene

  • Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344).

Gene Wiki entry for GORASP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GORASP1 Gene

Genomics for GORASP1 Gene

Regulatory Elements for GORASP1 Gene

Promoters for GORASP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GORASP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GORASP1 Gene

Chromosome:
3
Start:
39,096,599 bp from pter
End:
39,108,363 bp from pter
Size:
11,765 bases
Orientation:
Minus strand

Genomic View for GORASP1 Gene

Genes around GORASP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GORASP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GORASP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GORASP1 Gene

Proteins for GORASP1 Gene

  • Protein details for GORASP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQQ3-GORS1_HUMAN
    Recommended name:
    Golgi reassembly-stacking protein 1
    Protein Accession:
    Q9BQQ3
    Secondary Accessions:
    • B3KWC8
    • Q3SYG7
    • Q8N272
    • Q96H42

    Protein attributes for GORASP1 Gene

    Size:
    440 amino acids
    Molecular mass:
    46482 Da
    Quaternary structure:
    • Homodimer. Forms higher-order oligomers under interphase but not mitotic conditions. Dimers of the protein on one membrane might be able to interact with dimers on another and so stack cisternae (By similarity). Interacts with the C-terminus of GOLGA2/GM130 under both mitotic and non-mitotic conditions (PubMed:16489344). The interaction is critical for the correct targeting of both proteins to the cis-Golgi (By similarity). The complex binds to the vesicle docking protein p115/USO1. Interacts with TMED2 and TMED3 (By similarity).

    Three dimensional structures from OCA and Proteopedia for GORASP1 Gene

    Alternative splice isoforms for GORASP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GORASP1 Gene

Proteomics data for GORASP1 Gene at MOPED

Post-translational modifications for GORASP1 Gene

  • Phosphorylated by CDC2/B1 and PLK kinases during mitosis. Phosphorylation cycle correlates with the cisternal stacking cycle. Phosphorylation of the homodimer prevents the association of dimers into higher-order oligomers, leading to cisternal unstacking.
  • Target for caspase-3 cleavage during apoptosis. The cleavage contributes to Golgi fragmentation and occurs very early in the execution phase of apoptosis (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GORASP1 Gene

Domains & Families for GORASP1 Gene

Gene Families for GORASP1 Gene

Protein Domains for GORASP1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BQQ3

UniProtKB/Swiss-Prot:

GORS1_HUMAN :
  • Contains 1 PDZ (DHR) domain.
  • Belongs to the GORASP family.
Domain:
  • Contains 1 PDZ (DHR) domain.
Family:
  • Belongs to the GORASP family.
genes like me logo Genes that share domains with GORASP1: view

Function for GORASP1 Gene

Molecular function for GORASP1 Gene

UniProtKB/Swiss-Prot Function:
Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344).
genes like me logo Genes that share phenotypes with GORASP1: view

Human Phenotype Ontology for GORASP1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for GORASP1 Gene

Localization for GORASP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GORASP1 Gene

Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Note=Undergoes rapid exchange with the cytosol. {ECO:0000269 PubMed:11706049}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GORASP1 Gene COMPARTMENTS Subcellular localization image for GORASP1 gene
Compartment Confidence
golgi apparatus 5
cytosol 2
nucleus 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for GORASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane TAS --
genes like me logo Genes that share ontologies with GORASP1: view

Pathways & Interactions for GORASP1 Gene

genes like me logo Genes that share pathways with GORASP1: view

Pathways by source for GORASP1 Gene

Gene Ontology (GO) - Biological Process for GORASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007030 Golgi organization ISS --
GO:0007092 activation of APC-Cdc20 complex activity TAS --
GO:0015031 protein transport IEA --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
genes like me logo Genes that share ontologies with GORASP1: view

No data available for SIGNOR curated interactions for GORASP1 Gene

Drugs & Compounds for GORASP1 Gene

(2) Drugs for GORASP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for GORASP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GORASP1: view

Transcripts for GORASP1 Gene

Unigene Clusters for GORASP1 Gene

Golgi reassembly stacking protein 1, 65kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GORASP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g · 4h · 4i · 4j ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - - -
SP10: - - - - - -
SP11: -
SP12: - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - - - - - - - - - -
SP15: - - - - - - - - - - -
SP16: - - - - - - - - -
SP17: - - - - - - - - - - - - - - - - - - - - -
SP18: - - - - - - - -
SP19: - - - - - - -
SP20: - - - - - - - - - - - - - - - - - - -
SP21: - - - - -
SP22: - - - - - -
SP23: - - - - - - -
SP24: - - - - - - - - - - - - - - - - - - -
SP25: - - - - - - - - - - - - - - - - - - - - -
SP26: - - - - - -
SP27:
SP28: - - - -
SP29: - - - - - - - - - - - - - - - - - - -
SP30: - -
SP31:

ExUns: 8c · 8d · 8e · 8f · 8g · 8h ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b
SP1: - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9: - - -
SP10:
SP11: - -
SP12: - - - - - - - - -
SP13: - -
SP14: - - - - - - -
SP15:
SP16:
SP17: - - - - - -
SP18:
SP19:
SP20: - - - -
SP21:
SP22:
SP23:
SP24: - -
SP25: - - - - - - - - - - -
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:

Relevant External Links for GORASP1 Gene

GeneLoc Exon Structure for
GORASP1
ECgene alternative splicing isoforms for
GORASP1

Expression for GORASP1 Gene

mRNA expression in normal human tissues for GORASP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GORASP1 Gene

This gene is overexpressed in Liver (13.3), Pancreas (9.4), Retina (8.9), and Skin (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GORASP1 Gene



SOURCE GeneReport for Unigene cluster for GORASP1 Gene Hs.721946

genes like me logo Genes that share expression patterns with GORASP1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GORASP1 Gene

Orthologs for GORASP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GORASP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GORASP1 35
  • 85.22 (n)
  • 85.45 (a)
GORASP1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GORASP1 35
  • 88.22 (n)
  • 87.53 (a)
GORASP1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gorasp1 35
  • 82.09 (n)
  • 83.72 (a)
Gorasp1 16
Gorasp1 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GORASP1 35
  • 99.92 (n)
  • 100 (a)
GORASP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gorasp1 35
  • 82.63 (n)
  • 82.94 (a)
oppossum
(Monodelphis domestica)
Mammalia GORASP1 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GORASP1 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves GORASP1 35
  • 63.4 (n)
  • 62.7 (a)
GORASP1 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GORASP1 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gorasp1 35
  • 67.25 (n)
  • 68.31 (a)
zebrafish
(Danio rerio)
Actinopterygii CU633479.5 36
  • 69 (a)
OneToMany
gorasp1 36
  • 39 (a)
OneToMany
GORASP1 (2 of 3) 36
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7809 37
  • 61 (a)
Grasp65 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y42H9AR.1 37
  • 57 (a)
Y42H9AR.1 36
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GRH1 36
  • 19 (a)
OneToMany
GRH1 38
Species with no ortholog for GORASP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GORASP1 Gene

ENSEMBL:
Gene Tree for GORASP1 (if available)
TreeFam:
Gene Tree for GORASP1 (if available)

Paralogs for GORASP1 Gene

Paralogs for GORASP1 Gene

genes like me logo Genes that share paralogs with GORASP1: view

Variants for GORASP1 Gene

Sequence variations from dbSNP and Humsavar for GORASP1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1109643 - 39,098,285(-) TGGGA(C/T)GGAGG nc-transcript-variant, reference, missense
rs1122818 -- 39,099,605(+) CAGGA(A/G)CACTG intron-variant
rs2293306 -- 39,101,070(+) AGGCC(A/G)GCAAG nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime
rs2293307 -- 39,101,213(+) CCTCT(A/G)TCCCT intron-variant
rs2293308 -- 39,103,419(+) AGATG(A/G)AGACA intron-variant

Variation tolerance for GORASP1 Gene

Residual Variation Intolerance Score: 72.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GORASP1 Gene

HapMap Linkage Disequilibrium report
GORASP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GORASP1 Gene

Disorders for GORASP1 Gene

Relevant External Links for GORASP1

Genetic Association Database (GAD)
GORASP1
Human Genome Epidemiology (HuGE) Navigator
GORASP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GORASP1

No disorders were found for GORASP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GORASP1 Gene

Publications for GORASP1 Gene

  1. The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment. (PMID: 11781572) Marra P. … De Matteis M.A. (Nat. Cell Biol. 2001) 3 4 23 67
  2. GRASP55 and GRASP65 play complementary and essential roles in Golgi cisternal stacking. (PMID: 20083603) Xiang Y. … Wang Y. (J. Cell Biol. 2010) 3 23
  3. The role of GRASP65 in Golgi cisternal stacking and cell cycle progression. (PMID: 20214750) Tang D. … Wang Y. (Traffic 2010) 3 23
  4. GRASP65 and GRASP55 sequentially promote the transport of C-terminal valine-bearing cargos to and through the Golgi complex. (PMID: 19840934) D'Angelo G. … Bonatti S. (J. Biol. Chem. 2009) 3 23
  5. GM130 and GRASP65-dependent lateral cisternal fusion allows uniform Golgi-enzyme distribution. (PMID: 16489344) Puthenveedu M.A. … Linstedt A.D. (Nat. Cell Biol. 2006) 3 23

Products for GORASP1 Gene

Sources for GORASP1 Gene

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