Aliases for GORASP1 Gene
External Ids for GORASP1 Gene
Previous HGNC Symbols for GORASP1 Gene
Previous GeneCards Identifiers for GORASP1 Gene
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
GeneCards Summary for GORASP1 Gene
GORASP1 (Golgi Reassembly Stacking Protein 1) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Cell Cycle, Mitotic. An important paralog of this gene is GORASP2.
UniProtKB/Swiss-Prot for GORASP1 Gene
Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344).