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Aliases for GOPC Gene

Aliases for GOPC Gene

  • Golgi-Associated PDZ And Coiled-Coil Motif Containing 2 3 5
  • PDZ Protein Interacting Specifically With TC10 3 4
  • CFTR-Associated Ligand 3 4
  • Fused In Glioblastoma 3 4
  • PIST 3 4
  • FIG 3 4
  • CAL 3 4
  • PDZ/Coiled-Coil Domain Binding Partner For The Rho-Family GTPase TC10 3
  • Golgi Associated PDZ And Coiled-Coil Motif Containing Protein 3
  • Golgi-Associated PDZ And Coiled-Coil Motif Containing Protein 3
  • DJ94G16.2 PIST 3
  • DJ94G16.2 3
  • GOPC1 3

External Ids for GOPC Gene

Previous GeneCards Identifiers for GOPC Gene

  • GC01P9W0083
  • GC06M117927
  • GC06M117929
  • GC06M117988
  • GC06M117639
  • GC06M115462
  • GC06M117318

Summaries for GOPC Gene

Entrez Gene Summary for GOPC Gene

  • This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for GOPC Gene

GOPC (Golgi-Associated PDZ And Coiled-Coil Motif Containing) is a Protein Coding gene. Diseases associated with GOPC include glioblastoma and cystic fibrosis. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include protein homodimerization activity and ion channel binding. An important paralog of this gene is SNTG1.

UniProtKB/Swiss-Prot for GOPC Gene

  • Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.

Gene Wiki entry for GOPC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOPC Gene

Genomics for GOPC Gene

Regulatory Elements for GOPC Gene

Promoters for GOPC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GOPC on UCSC Golden Path with GeneCards custom track

Genomic Location for GOPC Gene

Chromosome:
6
Start:
117,560,269 bp from pter
End:
117,602,542 bp from pter
Size:
42,274 bases
Orientation:
Minus strand

Genomic View for GOPC Gene

Genes around GOPC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOPC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOPC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOPC Gene

Proteins for GOPC Gene

  • Protein details for GOPC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD26-GOPC_HUMAN
    Recommended name:
    Golgi-associated PDZ and coiled-coil motif-containing protein
    Protein Accession:
    Q9HD26
    Secondary Accessions:
    • A6NM30
    • Q59FS4
    • Q969U8

    Protein attributes for GOPC Gene

    Size:
    462 amino acids
    Molecular mass:
    50520 Da
    Quaternary structure:
    • Homooligomer. Interacts with FZD5, FZD8, GRID2, BECN1, CSPG5 and CLCN3. May interact with CACNG2 (By similarity). Interacts with STX6, CFTR, ASIC3, GOLGA3, NLGN1 and RHOQ.
    SequenceCaution:
    • Sequence=BAD92622.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GOPC Gene

    Alternative splice isoforms for GOPC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOPC Gene

Proteomics data for GOPC Gene at MOPED

Post-translational modifications for GOPC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GOPC Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GOPC (PIST)

No data available for DME Specific Peptides for GOPC Gene

Domains & Families for GOPC Gene

Gene Families for GOPC Gene

Protein Domains for GOPC Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GOPC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HD26

UniProtKB/Swiss-Prot:

GOPC_HUMAN :
  • The PDZ domain mediates interactions with FZD5, FZD8, ASIC3, GRID2, CLCN3 (By similarity). Mediates also interaction with CFTR and ADRB1.
Domain:
  • The PDZ domain mediates interactions with FZD5, FZD8, ASIC3, GRID2, CLCN3 (By similarity). Mediates also interaction with CFTR and ADRB1.
  • The coiled-coil region probably mediates association to membranes, targeting to the Golgi, and interactions with GOLGA3, and STX6. May also mediate interaction with RHOQ (By similarity).
  • Contains 1 PDZ (DHR) domain.
genes like me logo Genes that share domains with GOPC: view

Function for GOPC Gene

Molecular function for GOPC Gene

UniProtKB/Swiss-Prot Function:
Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.
genes like me logo Genes that share phenotypes with GOPC: view

Animal Models for GOPC Gene

MGI Knock Outs for GOPC:

Animal Model Products

miRNA for GOPC Gene

miRTarBase miRNAs that target GOPC

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GOPC Gene

Localization for GOPC Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOPC Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Note=Enriched in synaptosomal and postsynaptic densities (PSD) fractions. Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GOPC Gene COMPARTMENTS Subcellular localization image for GOPC gene
Compartment Confidence
golgi apparatus 5
lysosome 5
plasma membrane 5
vacuole 5
cytosol 4
nucleus 3
endosome 1

Gene Ontology (GO) - Cellular Components for GOPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane TAS --
GO:0005886 plasma membrane TAS --
GO:0030140 trans-Golgi network transport vesicle NAS 11384996
GO:0030425 dendrite IEA --
GO:0030660 Golgi-associated vesicle membrane TAS --
genes like me logo Genes that share ontologies with GOPC: view

Pathways & Interactions for GOPC Gene

genes like me logo Genes that share pathways with GOPC: view

SIGNOR curated interactions for GOPC Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for GOPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006893 Golgi to plasma membrane transport NAS 11707463
GO:0045176 apical protein localization NAS 11707463
genes like me logo Genes that share ontologies with GOPC: view

Drugs & Compounds for GOPC Gene

(2) Additional Compounds for GOPC Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
genes like me logo Genes that share compounds with GOPC: view

Transcripts for GOPC Gene

mRNA/cDNA for GOPC Gene

Unigene Clusters for GOPC Gene

Golgi-associated PDZ and coiled-coil motif containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GOPC Gene

No ASD Table

Relevant External Links for GOPC Gene

GeneLoc Exon Structure for
GOPC
ECgene alternative splicing isoforms for
GOPC

Expression for GOPC Gene

mRNA expression in normal human tissues for GOPC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GOPC Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.0), Skin (8.3), and Salivary gland (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GOPC Gene



SOURCE GeneReport for Unigene cluster for GOPC Gene Hs.191539

mRNA Expression by UniProt/SwissProt for GOPC Gene

Q9HD26-GOPC_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with GOPC: view

Protein tissue co-expression partners for GOPC Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for GOPC Gene

Orthologs for GOPC Gene

This gene was present in the common ancestor of animals.

Orthologs for GOPC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOPC 36
  • 100 (a)
OneToOne
GOPC 35
  • 99.64 (n)
  • 99.57 (a)
cow
(Bos Taurus)
Mammalia GOPC 36
  • 96 (a)
OneToOne
GOPC 35
  • 92.25 (n)
  • 96.61 (a)
dog
(Canis familiaris)
Mammalia GOPC 35
  • 91.5 (n)
  • 94.74 (a)
GOPC 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gopc 36
  • 92 (a)
OneToOne
Gopc 16
Gopc 35
  • 86.26 (n)
  • 91.89 (a)
oppossum
(Monodelphis domestica)
Mammalia GOPC 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GOPC 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves GOPC 35
  • 80.52 (n)
  • 88.36 (a)
GOPC 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GOPC 36
  • 87 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii -- 35
gopc 35
  • 71.26 (n)
  • 81.24 (a)
gopc 36
  • 77 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gopc-1 36
  • 52 (a)
OneToOne
gopc-1 35
  • 57.1 (n)
  • 58.24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for GOPC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GOPC Gene

ENSEMBL:
Gene Tree for GOPC (if available)
TreeFam:
Gene Tree for GOPC (if available)

Paralogs for GOPC Gene

Paralogs for GOPC Gene

(4) SIMAP similar genes for GOPC Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GOPC: view

Variants for GOPC Gene

Sequence variations from dbSNP and Humsavar for GOPC Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs210616 -- 117,586,131(-) ATTTA(A/C)ATTCC intron-variant
rs210639 -- 117,571,941(-) actta(C/T)ggagt intron-variant
rs210640 -- 117,572,721(-) CTAGG(A/G)CACTG intron-variant
rs210641 -- 117,574,122(-) AGGCA(C/T)GCCAC intron-variant
rs1967193 -- 117,600,440(-) ATTTC(A/G)TGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GOPC Gene

Variant ID Type Subtype PubMed ID
nsv507357 CNV Insertion 20534489

Variation tolerance for GOPC Gene

Residual Variation Intolerance Score: 32.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GOPC Gene

HapMap Linkage Disequilibrium report
GOPC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOPC Gene

Disorders for GOPC Gene

MalaCards: The human disease database

(3) MalaCards diseases for GOPC Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
glioblastoma
  • glioblastoma multiforme
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
intrahepatic cholangiocarcinoma
  • intrahepatic bile duct carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search GOPC in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

GOPC_HUMAN
  • Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity. {ECO:0000269 PubMed:12661006}.

Relevant External Links for GOPC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GOPC
genes like me logo Genes that share disorders with GOPC: view

No data available for Genatlas for GOPC Gene

Publications for GOPC Gene

  1. PIST: a novel PDZ/coiled-coil domain binding partner for the rho- family GTPase TC10. (PMID: 11162552) Neudauer C.L. … Macara I.G. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 67
  2. The PDZ/coiled-coil domain containing protein PIST modulates insulin secretion in MIN6 insulinoma cells by interacting with somatostatin receptor subtype 5. (PMID: 16263117) Wente W. … Kreienkamp H.J. (FEBS Lett. 2005) 3 23
  3. The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator- interacting PDZ proteins. (PMID: 12471024) Gentzsch M. … Riordan J.R. (J. Biol. Chem. 2003) 3 23
  4. Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21). (PMID: 12661006) Charest A. … Housman D. (Genes Chromosomes Cancer 2003) 3 23
  5. A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression. (PMID: 11707463) Cheng J. … Guggino W.B. (J. Biol. Chem. 2002) 3 23

Products for GOPC Gene

Sources for GOPC Gene

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