Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GOPC Gene

protein-coding   GIFtS: 58
GCID: GC06M117639

Golgi-Associated PDZ And Coiled-Coil Motif Containing

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Golgi-Associated PDZ And Coiled-Coil Motif Containing1 2     GOPC12
CAL2 3 5     dJ94G16.22
FIG2 3 5     DJ94G16.2 PIST2
PIST2 3 5     Golgi Associated PDZ And Coiled-Coil Motif Containing Protein2
Fused In Glioblastoma2 3     Golgi-Associated PDZ And Coiled-Coil Motif Containing Protein2
CFTR-Associated Ligand2 3     Golgi-Associated PDZ And Coiled-Coil Motif-Containing Protein2
PDZ Protein Interacting Specifically With TC102 3     PDZ/Coiled-Coil Domain Binding Partner For The Rho-Family GTPase TC102

External Ids:    HGNC: 176431   Entrez Gene: 571202   Ensembl: ENSG000000479327   OMIM: 6068455   UniProtKB: Q9HD263   

Export aliases for GOPC gene to outside databases

Previous GC identifers: GC01P9W0083 GC06M117927 GC06M117929 GC06M117988 GC06M115462


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GOPC Gene:
This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them
bind other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein
have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for GOPC Gene:
GOPC (golgi-associated PDZ and coiled-coil motif containing) is a protein-coding gene. Diseases associated with GOPC include globozoospermia, and infertility. GO annotations related to this gene include ion channel binding and protein homodimerization activity. An important paralog of this gene is SNTA1.

UniProtKB/Swiss-Prot: GOPC_HUMAN, Q9HD26
Function: Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents
and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the
intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR
intracellular retention and degradation in the lysosomes

Gene Wiki entry for GOPC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GOPC gene promoter:
         Pax-5   AML1a   HNF-3beta   YY1   Evi-1   HOXA5   COMP1   LHX3a/Lhx3a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGOPC promoter sequence
   Search Chromatin IP Primers for GOPC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GOPC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q22.1   HGNC cytogenetic band: 6q21

GOPC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GOPC gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M117639:  view genomic region     (about GC identifiers)

Start:
117,639,374 bp from pter      End:
117,923,705 bp from pter
Size:
284,332 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GOPC_HUMAN, Q9HD26 (See protein sequence)
Recommended Name: Golgi-associated PDZ and coiled-coil motif-containing protein  
Size: 462 amino acids; 50520 Da
Subunit: Homooligomer. Interacts with FZD5, FZD8, GRID2, BECN1, CSPG5 and CLCN3. May interact with CACNG2 (By
similarity). Interacts with STX6, CFTR, ASIC3, GOLGA3, NLGN1 and RHOQ
Sequence caution: Sequence=BAD92622.1; Type=Erroneous initiation;
Selected PDB 3D structures from and Proteopedia for GOPC (see all 16):
2DC2 (3D)        2LOB (3D)        4E34 (3D)        4E35 (3D)        4JOE (3D)        4JOF (3D)    
Secondary accessions: A6NM30 Q59FS4 Q969U8
Alternative splicing: 3 isoforms:  Q9HD26-1   Q9HD26-2   Q9HD26-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GOPC: NX_Q9HD26

Explore proteomics data for GOPC at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GOPC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001017408.1  NP_065132.1  

    ENSEMBL proteins: 
     ENSP00000357484   ENSP00000052569   ENSP00000445690  

    GOPC Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for GOPC
    OriGene Protein Over-expression Lysate for GOPC
    OriGene MassSpec for GOPC
    OriGene Custom Protein Services for GOPC
    GenScript Custom Purified and Recombinant Proteins Services for GOPC
    Novus Biologicals GOPC Proteins
    Novus Biologicals GOPC Lysate
    Sino Biological Recombinant Protein for GOPC
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GOPC
    Cloud-Clone Corp. Proteins for GOPC

    GOPC Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for GOPC  (PIST)
    OriGene Antibodies for GOPC
    OriGene Custom Antibody Services for GOPC
    Novus Biologicals GOPC Antibodies
    Abcam antibodies for GOPC
    Cloud-Clone Corp. Antibodies for GOPC
    ThermoFisher Antibodies for GOPC
    LSBio Antibodies in human, mouse, rat for GOPC

    GOPC Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GOPC
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GOPC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GOPC
    Cloud-Clone Corp. CLIAs for GOPC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q9HD26

    ProtoNet protein and cluster: Q9HD26

    1 Blocks protein domain: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: GOPC_HUMAN, Q9HD26
    Domain: The PDZ domain mediates interactions with FZD5, FZD8, ASIC3, GRID2, CLCN3 (By similarity). Mediates also
    interaction with CFTR and ADRB1
    Domain: The coiled-coil region probably mediates association to membranes, targeting to the Golgi, and
    interactions with GOLGA3, and STX6. May also mediate interaction with RHOQ (By similarity)
    Similarity: Contains 1 PDZ (DHR) domain


    GOPC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GOPC_HUMAN, Q9HD26
    Function: Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents
    and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the
    intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR
    intracellular retention and degradation in the lysosomes

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005083small GTPase regulator activity IEA--
    GO:0005109frizzled binding IEA--
    GO:0005515protein binding IPI11384996
    GO:0008022protein C-terminus binding IEA--
    GO:0042803protein homodimerization activity IEA--
         
    GOPC for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gopc):
     reproductive system 

    GOPC for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GOPC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GOPC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GOPC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GOPC

    miRNA
    Products:
        
    miRTarBase miRNAs that target GOPC:
    hsa-mir-130b-3p (MIRT020115), hsa-mir-103a-3p (MIRT027025)

    Block miRNA regulation of human, mouse, rat GOPC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GOPC (see all 60):
    hsa-miR-142-5p hsa-miR-548j hsa-let-7d hsa-miR-548k hsa-miR-374a hsa-miR-519a hsa-miR-548l hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidGOPC 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GOPC
    Predesigned siRNA for gene silencing in human, mouse, rat GOPC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GOPC

    Clone
    Products:
         
    OriGene clones in human, mouse for GOPC (see all 12)
    OriGene ORF clones in mouse, rat for GOPC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GOPC (NM_020399)
    Sino Biological Human cDNA Clone for GOPC
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GOPC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GOPC

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GOPC
    Browse ESI BIO Cell Lines and PureStem Progenitors for GOPC 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOPC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GOPC_HUMAN, Q9HD26: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus,
    trans-Golgi network membrane; Peripheral membrane protein. Cell junction, synapse (By similarity). Cell junction,
    synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell projection, dendrite (By
    similarity). Note=Enriched in synaptosomal and postsynaptic densities (PSD) fractions (By similarity). Expressed
    in cell bodies and dendrites of Purkinje cells (By similarity). Localized at the trans-Golgi network (TGN) of
    spermatids and the medulla of round spermatides (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    plasma membrane5
    cytosol3
    nucleus3
    cytoskeleton2

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005886plasma membrane NAS11707463
    GO:0014069postsynaptic density IEA--

    GOPC for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GOPC About                                                                                                See pathways by source

    SuperPathContained pathways About
    1ER to Golgi Transport
    Delta508 CFTR traffic ER to Golgi in CF0.36
    Normal wtCFTR traffic ER to Golgi 0.36
    2Clathrin dependent protein traffic
    wtCFTR and delta508 CFTR traffic Generic schema norm and CF 0.37
    3Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for GOPC
        Cytoskeletal Signaling

    3 GeneGo (Thomson Reuters) Pathways for GOPC
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / ER-to-Golgi in CF
    Normal wtCFTR traffic / ER-to-Golgi




    GOPC for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GOPC
    Interactions:

        GeneGlobe Interaction Network for GOPC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GOPC (Q9HD261, 2, 3 ENSP000003574844) via UniProtKB, MINT, STRING, and/or I2D (see all 129)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLCN3P517902, 3, ENSP000002615144MINT-1783634 MINT-1790205 I2D: score=3 STRING: ENSP00000261514
    CFTRP135692, 3, ENSP000000030844MINT-1783772 MINT-1783657 I2D: score=5 STRING: ENSP00000003084
    VIMP086702, 3, ENSP000002242374MINT-67944 I2D: score=5 STRING: ENSP00000224237
    GRID2O434243, ENSP000002820204I2D: score=4 STRING: ENSP00000282020
    ASIC3Q9UHC33, ENSP000002975124I2D: score=3 STRING: ENSP00000297512
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006888ER to Golgi vesicle-mediated transport NAS11707463
    GO:0006893Golgi to plasma membrane transport NAS11707463
    GO:0007289spermatid nucleus differentiation IEA--
    GO:0015031protein transport IEA--
    GO:0043004cytoplasmic sequestering of CFTR protein NAS11707463

    GOPC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GOPC

    1 HMDB Compound for GOPC    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--

    1 Novoseek inferred chemical compound relationship for GOPC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chloride 45.4 1 11707463 (1)



    GOPC for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GOPC gene (2 alternative transcripts): 
    NM_001017408.2  NM_020399.3  

    Unigene Cluster for GOPC:

    Golgi-associated PDZ and coiled-coil motif containing
    Hs.191539  [show with all ESTs]
    Unigene Representative Sequence: NM_020399
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467125(uc003pxq.1) ENST00000368498 ENST00000052569(uc003pxu.3 uc003pxv.3)
    ENST00000535237

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GOPC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GOPC (see all 60):
    hsa-miR-142-5p hsa-miR-548j hsa-let-7d hsa-miR-548k hsa-miR-374a hsa-miR-519a hsa-miR-548l hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidGOPC 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GOPC
    Predesigned siRNA for gene silencing in human, mouse, rat GOPC
    Clone
    Products:
         
    OriGene clones in human, mouse for GOPC (see all 12)
    OriGene ORF clones in mouse, rat for GOPC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GOPC (NM_020399)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GOPC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GOPC
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GOPC
    OriGene qSTAR qPCR primer pairs in human, mouse for GOPC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GOPC
      QuantiTect SYBR Green Assays in human, mouse, rat GOPC
      QuantiFast Probe-based Assays in human, mouse, rat GOPC

    Additional mRNA sequence: 

    AF287894.1 AF450008.1 AJ420540.1 AJ420595.1 AK025074.1 AK314486.1 AY033606.1 BC009553.2 

    11 DOTS entries:

    DT.91983045  DT.117896  DT.100788505  DT.209986  DT.121323900  DT.100788504  DT.100788506  DT.100736785 
    DT.95075877  DT.92063816  DT.92424290 

    Selected AceView cDNA sequences (see all 245):

    AI262390 AA394059 T30292 AA939322 W24201 AI655862 AI679786 CA442919 
    AI970512 AA933634 AA280266 AI797345 BQ023687 AI089113 AI928356 BM905862 
    N79051 AI123743 AA290953 AA906073 BE079339 AW304241 N32368 AI674993 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GOPC expression in normal human tissues (normalized intensities)      GOPC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAAGATGC
    GOPC Expression
    About this image


    GOPC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Kidney (Urinary System)
             Metanephros
    GOPC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GOPC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.191539

    UniProtKB/Swiss-Prot: GOPC_HUMAN, Q9HD26
    Tissue specificity: Ubiquitously expressed

        Custom PCR Arrays for GOPC
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GOPC
    OriGene qSTAR qPCR primer pairs in human, mouse for GOPC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GOPC
    QuantiTect SYBR Green Assays in human, mouse, rat GOPC
    QuantiFast Probe-based Assays in human, mouse, rat GOPC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOPC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for GOPC gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gopc1 , 5 golgi associated PDZ and coiled-coil motif containing1, 5 86.26(n)1
    91.89(a)1
      10 (26.54 cM)5
    942211  NM_001199272.11  NP_001186201.11 
     523370245 
    chicken
    (Gallus gallus)
    Aves GOPC1 golgi-associated PDZ and coiled-coil motif containing 80.52(n)
    88.36(a)
      770364  XM_001233700.3  XP_001233701.3 
    lizard
    (Anolis carolinensis)
    Reptilia GOPC6
    golgi-associated PDZ and coiled-coil motif contain...
    87(a)
    1 ↔ 1
    1(185503198-185529993)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC057217.12   -- 79.06(n)    BC057217.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056565.12   -- 79.46(n)   393529  BC056565.1 
    worm
    (Caenorhabditis elegans)
    Secernentea gopc-11 gopc-1 57.1(n)
    58.24(a)
      3565651  NM_001026706.2  NP_001021877.2 


    ENSEMBL Gene Tree for GOPC (if available)
    TreeFam Gene Tree for GOPC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GOPC gene
    SNTA12  SNTB12  SNTG12  SNTB22  SNTG22  
    4 SIMAP similar genes for GOPC using alignment to 4 protein entries:     GOPC_HUMAN (see all proteins):
    LIN7C    TJP2    DLG4    LIN7A

    GOPC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GOPC (see all 573)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1481304141,2
    --117891606(+) AAGAAC/TATATA 2 -- int10--------
    rs1146722721,2
    C,F--117891674(+) ATACAC/TGTACT 2 -- int11Minor allele frequency- T:0.01WA 118
    rs1504582811,2
    C--117891725(+) GAAAA-/AAAAA 
     AAAAAAC
    CAGCC
    2 -- cds10--------
    rs1419353421,2
    --117891732(+) AGCCAC/TGTCTA 2 -- int10--------
    rs1507547261,2
    --117891770(+) GTATAC/TGGCAC 2 -- int10--------
    rs729655621,2
    C,F--117891826(+) TAAAGG/TTACAC 2 -- int11Minor allele frequency- T:0.12NA 120
    rs1904402901,2
    --117891839(+) AATAGC/TTGCTA 2 -- int10--------
    rs1452985961,2
    C--117892023(+) CTTACT/GGTAAT 4 /T syn11Minor allele frequency- G:0.00NA 4538
    rs2008688521,2
    C--117892088(+) ACCAAC/TACCTT 4 I V mis11Minor allele frequency- T:0.00EU 1319
    rs1491953941,2
    C,F--117892102(+) TTTTCT/CTTAGG 4 /K /R mis11Minor allele frequency- C:0.00NA 4538

    HapMap Linkage Disequilibrium report for GOPC (117639374 - 117889374 bp, first 250kb of GOPC)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GOPC:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv507357CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GOPC
    DNA2.0 Custom Variant and Variant Library Synthesis for GOPC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606845   
    OMIM disorders: 102530  
    UniProtKB/Swiss-Prot: GOPC_HUMAN, Q9HD26
  • Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An
    intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which
    has a constitutive receptor tyrosine kinase activity

  • 8 diseases for GOPC:    About MalaCards
    globozoospermia    infertility    cystic fibrosis    insulinoma
    sinusitis    neuroblastoma    multiple myeloma    myeloma

    1 disease from the University of Copenhagen DISEASES database for GOPC:
    Cystic fibrosis

    GOPC for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for GOPC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cystic fibrosis 44.7 1 11707463 (1)


    Export disorders for GOPC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GOPC gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with GOPC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PIST: a novel PDZ/coiled-coil domain binding partner for the rho- family GTPase TC10. (PubMed id 11162552)1, 2, 3 Neudauer C.L.... Macara I.G. (Biochem. Biophys. Res. Commun. 2001)
    2. A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression. (PubMed id 11707463)1, 2, 9 Cheng J.... Guggino W.B. (J. Biol. Chem. 2002)
    3. Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21). (PubMed id 12661006)1, 2, 9 Charest A....Housman D. (Genes Chromosomes Cancer 2003)
    4. Solution structure of GOPC PDZ domain and its interaction with the C- terminal motif of neuroligin. (PubMed id 16882988)1, 2 Li X.... Shi Y. (Protein Sci. 2006)
    5. Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10. (PubMed id 15546864)1, 2 Cheng J.... Guggino W.B. (J. Biol. Chem. 2005)
    6. Isoform-specific interaction of golgin-160 with the Golgi-associated protein PIST. (PubMed id 15951434)1, 2 Hicks S.W. and Machamer C.E. (J. Biol. Chem. 2005)
    7. Modulation of mature cystic fibrosis transmembrane regulator protein by the PDZ domain protein CAL. (PubMed id 14570915)1, 2 Cheng J.... Guggino W.B. (J. Biol. Chem. 2004)
    8. Interaction with cystic fibrosis transmembrane conductance regulator- associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression. (PubMed id 15358775)1, 2 He J.... Hall R.A. (J. Biol. Chem. 2004)
    9. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    10. PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. (PubMed id 15317815)1, 2 Hruska-Hageman A.M....Welsh M.J. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 57120 HGNC: 17643 AceView: ROS1andGOPC Ensembl:ENSG00000047932 euGenes: HUgn57120
    ECgene: GOPC H-InvDB: GOPC

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GOPC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GOPC gene:
    Search GeneIP for patents involving GOPC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GOPC   OriGene RNAi products in human, mouse, rat for GOPC  
     OriGene qPCR primer pairs and template standards for GOPC   OriGene Protein Over-expression Lysate for GOPC  
     OriGene MassSpec something-or-other for GOPC   OriGene clones in human, mouse for GOPC  
     OriGene qSTAR qPCR primer pairs in human, mouse for GOPC   OriGene Purified Protein for GOPC  
     OriGene ORF clones in mouse, rat for GOPC   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GOPC   OriGene Custom Protein Services for GOPC  

     
     
     Block miRNA regulation of human, mouse, rat GOPC using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GOPC
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GOPC Predesigned siRNA for gene silencing in human, mouse, rat GOPC
     QuantiFast Probe-based Assays in human, mouse, rat GOPC QuantiTect SYBR Green Assays in human, mouse, rat GOPC
     Custom PCR Arrays for GOPC Search Chromatin IP Primers for GOPC
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GOPC  GeneGlobe Interaction Network for GOPC
     Regulatory tfbs in GOPC promoter
     GenScript Custom Purified and Recombinant Proteins Services for GOPC GenScript cDNA clones with any tag delivered in your preferred vector for GOPC
     GenScript Custom Assay Services for GOPC GenScript Custom overexpressing Cell Line Services for GOPC
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for GOPC  (PIST)

     Search Tocris compounds for GOPC
     Proteins for GOPC
     Browse Sino Biological Cell Lysates
     cDNA Clones for GOPC
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GOPC antibodies
     GOPC proteins
     GOPC lysates
     Antibodies for GOPC
     See all of Abcam's Antibodies, Kits and Proteins for GOPC
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for GOPC
     Proteins for GOPC
     Antibodies for GOPC
     ELISAs for GOPC
     CLIAs for GOPC



     Browse ESI BIO Cell Lines and PureStem Progenitors for GOPC
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOPC
     SwitchGear 3'UTR luciferase reporter plasmids for GOPC
     SwitchGear Promoter luciferase reporter plasmids for GOPC
     ThermoFisher Antibodies for GOPC
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GOPC
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GOPC
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GOPC
     LSBio Antibodies in human, mouse, rat for GOPC
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GOPC gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4