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Aliases for GON7 Gene

Aliases for GON7 Gene

  • GON7, KEOPS Complex Subunit Homolog 2 3 5
  • C14orf142 3 4
  • Chromosome 14 Open Reading Frame 142 2
  • Uncharacterized Protein C14orf142 3
  • EKC/KEOPS Complex Subunit GON7 3
  • PNAS-127 3

External Ids for GON7 Gene

Previous HGNC Symbols for GON7 Gene

  • C14orf142

Summaries for GON7 Gene

GeneCards Summary for GON7 Gene

GON7 (GON7, KEOPS Complex Subunit Homolog) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GON7 Gene

Genomics for GON7 Gene

Regulatory Elements for GON7 Gene

Enhancers for GON7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G093205 1.1 ENCODE 7.9 -0.1 -52 3.0 HDGF PKNOX1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 SLC30A9 FOS TMEM251 MOAP1 GON7 ENSG00000240096
GH14G092723 1.5 FANTOM5 Ensembl ENCODE 1.8 +481.8 481774 3.9 HDAC1 ATF1 THRB RARA FOS SMARCA5 HMG20B ZNF280D CEBPB ZEB2 TMEM251 SLC24A4 RIN3 MOAP1 GON7 LGMN GC14P092700
GH14G092846 1.5 FANTOM5 Ensembl ENCODE 1.7 +360.0 360014 1.4 HDAC1 ATF1 ZSCAN4 TCF12 GATA2 EGR1 FOS RELB IKZF2 CREM TMEM251 CHGA UNC79 RIN3 MOAP1 BTBD7 GON7 PIR36925 GC14P092879 GC14P092880
GH14G092866 0.9 FANTOM5 1.9 +340.7 340674 0.3 TBP FUS SIN3A ZSCAN9 ZNF48 YY1 SLC30A9 GLIS2 BCLAF1 SMAD5 TMEM251 UNC79 MOAP1 RIN3 GON7 BTBD7 GC14P092878 PIR36925 GC14P092880 GC14P092879
GH14G092784 1.3 FANTOM5 Ensembl ENCODE 1.2 +421.2 421238 1.9 TCF12 ZNF766 GATA2 ELK1 FOS CEBPB SMARCA4 IKZF1 KDM1A FOXJ2 TMEM251 GOLGA5 CPSF2 SLC24A4 MOAP1 RIN3 GON7 LGMN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GON7 on UCSC Golden Path with GeneCards custom track

Promoters for GON7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000072394 -86 2401 HDGF PKNOX1 ARID4B SIN3A FEZF1 YBX1 ZNF2 YY1 SLC30A9 FOS

Genomic Location for GON7 Gene

Chromosome:
14
Start:
93,202,892 bp from pter
End:
93,207,114 bp from pter
Size:
4,223 bases
Orientation:
Minus strand

Genomic View for GON7 Gene

Genes around GON7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GON7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GON7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GON7 Gene

Proteins for GON7 Gene

  • Protein details for GON7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXV9-CN142_HUMAN
    Recommended name:
    Uncharacterized protein C14orf142
    Protein Accession:
    Q9BXV9
    Secondary Accessions:
    • Q0D2N1
    • Q0P6C4
    • Q3B7W5

    Protein attributes for GON7 Gene

    Size:
    100 amino acids
    Molecular mass:
    10859 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK07544.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

neXtProt entry for GON7 Gene

Post-translational modifications for GON7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GON7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GON7 Gene

Domains & Families for GON7 Gene

Protein Domains for GON7 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GON7: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for GON7 Gene

Function for GON7 Gene

Gene Ontology (GO) - Molecular Function for GON7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27903914
genes like me logo Genes that share ontologies with GON7: view
genes like me logo Genes that share phenotypes with GON7: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GON7 Gene

Localization for GON7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GON7 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for GON7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000408 EKC/KEOPS complex IDA 27903914
GO:0005634 nucleus IDA 27903914
genes like me logo Genes that share ontologies with GON7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GON7 Gene

Pathways & Interactions for GON7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GON7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GON7 Gene

Transcripts for GON7 Gene

mRNA/cDNA for GON7 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GON7 Gene

No ASD Table

Relevant External Links for GON7 Gene

GeneLoc Exon Structure for
GON7
ECgene alternative splicing isoforms for
GON7

Expression for GON7 Gene

NURSA nuclear receptor signaling pathways regulating expression of GON7 Gene:

GON7

Evidence on tissue expression from TISSUES for GON7 Gene

  • Nervous system(4.3)
  • Blood(4.1)
  • Liver(4.1)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GON7 Gene

Orthologs for GON7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for GON7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C14H14orf142 34
  • 100 (n)
C14orf142 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C8H14orf142 34
  • 85.67 (n)
C14orf142 35
  • 77 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C21H14orf142 35 34
  • 84.67 (n)
OneToOne
mouse
(Mus musculus)
Mammalia AK010878 35 34
  • 77.89 (n)
OneToMany
Gm20604 35
  • 55 (a)
OneToMany
RP24-234J3.4 35
  • 52 (a)
OneToMany
Gon7 16
rat
(Rattus norvegicus)
Mammalia LOC100233176 34
  • 71.82 (n)
oppossum
(Monodelphis domestica)
Mammalia C14orf142 35
  • 38 (a)
OneToOne
Species where no ortholog for GON7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GON7 Gene

ENSEMBL:
Gene Tree for GON7 (if available)
TreeFam:
Gene Tree for GON7 (if available)

Paralogs for GON7 Gene

No data available for Paralogs for GON7 Gene

Variants for GON7 Gene

Sequence variations from dbSNP and Humsavar for GON7 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000058553 -- 93,208,895(+) TGGGT(G/T)CAAGT intron-variant, upstream-variant-2KB
rs1000334105 -- 93,203,707(+) TTGGC(C/T)GTTTT reference, missense
rs1000623525 -- 93,208,162(+) CTCAC(C/G)CTACA intron-variant, upstream-variant-2KB
rs1001680468 -- 93,202,483(+) TGCTT(C/G)AATCC downstream-variant-500B
rs1001766635 -- 93,208,799(+) TTCAC(-/T)TTTTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GON7 Gene

Variant ID Type Subtype PubMed ID
esv3635357 CNV gain 21293372

Variation tolerance for GON7 Gene

Residual Variation Intolerance Score: 77.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 8.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GON7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GON7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GON7 Gene

Disorders for GON7 Gene

Relevant External Links for GON7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GON7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GON7

No disorders were found for GON7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GON7 Gene

Publications for GON7 Gene

  1. Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7. (PMID: 27903914) Wan L.C. … Sicheri F. (Nucleic Acids Res. 2016) 2 3 64
  2. The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME. (PMID: 22912744) Costessi A. … Stunnenberg H.G. (PLoS ONE 2012) 2 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for GON7 Gene

Sources for GON7 Gene

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