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Aliases for GOLT1B Gene

Aliases for GOLT1B Gene

  • Golgi Transport 1B 2 3 5
  • Putative NF-Kappa-B-Activating Protein 470 3 4
  • Germ Cell Tumor 2 3 4
  • HGOT1a 3 4
  • GCT2 3 4
  • Golgi Transport 1 Homolog B (S. Cerevisiae) 2
  • Vesicle Transport Protein GOT1B 3
  • Golgi Transport 1 Homolog B 4
  • CGI-141 3
  • YMR292W 3
  • GOT1B 3
  • GOT1A 4
  • GOT1 3

External Ids for GOLT1B Gene

Previous GeneCards Identifiers for GOLT1B Gene

  • GC12P021547
  • GC12P021654
  • GC12P021428

Summaries for GOLT1B Gene

GeneCards Summary for GOLT1B Gene

GOLT1B (Golgi Transport 1B) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity and lipase activity. An important paralog of this gene is GOLT1A.

UniProtKB/Swiss-Prot for GOLT1B Gene

  • May be involved in fusion of ER-derived transport vesicles with the Golgi complex.

Gene Wiki entry for GOLT1B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLT1B Gene

Genomics for GOLT1B Gene

Regulatory Elements for GOLT1B Gene

Enhancers for GOLT1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F021500 1.1 ENCODE 7.6 -0.1 -61 2.7 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 FOS SP3 NFYC MXD4 PYROXD1 RECQL GOLT1B
GH12F021509 0.8 Ensembl ENCODE 0.4 +8.1 8065 1.0 SREBF1 RAD51 POLR2A USF2 ASH2L SIN3A PYROXD1 SPX ENSG00000256615 LDHB RECQL GOLT1B
GH12F021513 0.3 FANTOM5 0.4 +11.5 11492 0.4 GYS2 ENSG00000256615 LDHB GOLT1B SPX
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GOLT1B on UCSC Golden Path with GeneCards custom track

Promoters for GOLT1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000087291 -165 3201 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 FOS SP3 NFYC MXD4

Genomic Location for GOLT1B Gene

Chromosome:
12
Start:
21,501,765 bp from pter
End:
21,518,408 bp from pter
Size:
16,644 bases
Orientation:
Plus strand

Genomic View for GOLT1B Gene

Genes around GOLT1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLT1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLT1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLT1B Gene

Proteins for GOLT1B Gene

  • Protein details for GOLT1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3E0-GOT1B_HUMAN
    Recommended name:
    Vesicle transport protein GOT1B
    Protein Accession:
    Q9Y3E0
    Secondary Accessions:
    • B2R4R4
    • Q54A40
    • Q6I9W6
    • Q9P1R9

    Protein attributes for GOLT1B Gene

    Size:
    138 amino acids
    Molecular mass:
    15426 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF65181.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for GOLT1B Gene

Post-translational modifications for GOLT1B Gene

  • Ubiquitination at Lys 62
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GOLT1B Gene

Domains & Families for GOLT1B Gene

Protein Domains for GOLT1B Gene

Suggested Antigen Peptide Sequences for GOLT1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3E0

UniProtKB/Swiss-Prot:

GOT1B_HUMAN :
  • Belongs to the GOT1 family.
Family:
  • Belongs to the GOT1 family.
genes like me logo Genes that share domains with GOLT1B: view

No data available for Gene Families for GOLT1B Gene

Function for GOLT1B Gene

Molecular function for GOLT1B Gene

UniProtKB/Swiss-Prot Function:
May be involved in fusion of ER-derived transport vesicles with the Golgi complex.

Gene Ontology (GO) - Molecular Function for GOLT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
genes like me logo Genes that share ontologies with GOLT1B: view
genes like me logo Genes that share phenotypes with GOLT1B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLT1B Gene

Localization for GOLT1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLT1B Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLT1B gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 3
plasma membrane 2
lysosome 1

Gene Ontology (GO) - Cellular Components for GOLT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GOLT1B: view

Pathways & Interactions for GOLT1B Gene

SuperPathways for GOLT1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for GOLT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007165 signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
genes like me logo Genes that share ontologies with GOLT1B: view

No data available for Pathways by source and SIGNOR curated interactions for GOLT1B Gene

Transcripts for GOLT1B Gene

Unigene Clusters for GOLT1B Gene

Golgi transport 1B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOLT1B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - - - - -
SP6: - - - - - -
SP7:

Relevant External Links for GOLT1B Gene

GeneLoc Exon Structure for
GOLT1B
ECgene alternative splicing isoforms for
GOLT1B

Expression for GOLT1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GOLT1B Gene

Protein differential expression in normal tissues from HIPED for GOLT1B Gene

This gene is overexpressed in Nasal epithelium (49.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GOLT1B Gene



NURSA nuclear receptor signaling pathways regulating expression of GOLT1B Gene:

GOLT1B

SOURCE GeneReport for Unigene cluster for GOLT1B Gene:

Hs.62275

mRNA Expression by UniProt/SwissProt for GOLT1B Gene:

Q9Y3E0-GOT1B_HUMAN
Tissue specificity: Widely expressed. Tends to be up-regulated in seminomas compared to normal testis.
genes like me logo Genes that share expression patterns with GOLT1B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for GOLT1B Gene

Orthologs for GOLT1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GOLT1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOLT1B 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia GOLT1B 34 35
  • 96.14 (n)
cow
(Bos Taurus)
Mammalia GOLT1B 34 35
  • 94.44 (n)
oppossum
(Monodelphis domestica)
Mammalia GOLT1B 35
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Golt1b 34
  • 89.86 (n)
mouse
(Mus musculus)
Mammalia Golt1b 34 16 35
  • 89.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GOLT1B 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves GOLT1B 34
  • 86.96 (n)
lizard
(Anolis carolinensis)
Reptilia GOLT1B 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia golt1b 34
  • 75.33 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33070 34
zebrafish
(Danio rerio)
Actinopterygii golt1ba 35
  • 86 (a)
OneToMany
golt1bb 34 35
  • 73.43 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32576 34 35
  • 61.76 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002357 34
  • 60.54 (n)
worm
(Caenorhabditis elegans)
Secernentea F41C3.4 34 35
  • 57.21 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GOT1 34 35 37
  • 55.3 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A09801g 34
  • 50.65 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR337W 34
  • 46.25 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G49420 34
  • 57.55 (n)
rice
(Oryza sativa)
Liliopsida Os03g0209400 34
  • 58.07 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5537 35
  • 62 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU06396 34
  • 54.79 (n)
Species where no ortholog for GOLT1B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GOLT1B Gene

ENSEMBL:
Gene Tree for GOLT1B (if available)
TreeFam:
Gene Tree for GOLT1B (if available)

Paralogs for GOLT1B Gene

Paralogs for GOLT1B Gene

(1) SIMAP similar genes for GOLT1B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GOLT1B: view

Variants for GOLT1B Gene

Sequence variations from dbSNP and Humsavar for GOLT1B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1048617 -- 21,518,257(+) GTGTT(C/T)TATTT utr-variant-3-prime
rs10492117 -- 21,506,434(+) CAGTA(A/G)AGAAG intron-variant
rs1060126 -- 21,501,897(+) GTGCT(G/T)TCGCC upstream-variant-2KB, utr-variant-5-prime
rs1061626 -- 21,501,535(-) GTCGG(A/C)GATCG upstream-variant-2KB, utr-variant-5-prime
rs1061627 -- 21,501,473(-) TAGAC(C/T)GGGCT upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GOLT1B Gene

Variant ID Type Subtype PubMed ID
nsv557743 CNV gain 21841781
nsv557741 CNV gain 21841781
nsv528556 CNV gain 19592680
nsv1054220 CNV gain 25217958

Variation tolerance for GOLT1B Gene

Residual Variation Intolerance Score: 59.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GOLT1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLT1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLT1B Gene

Disorders for GOLT1B Gene

Relevant External Links for GOLT1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GOLT1B

No disorders were found for GOLT1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOLT1B Gene

Publications for GOLT1B Gene

  1. Genomic and expression analysis of the 12p11-p12 amplicon using EST arrays identifies two novel amplified and overexpressed genes. (PMID: 12414650) Bourdon V. … Chaganti R.S. (Cancer Res. 2002) 2 3 4 64
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A. … Sugano S. (Oncogene 2003) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for GOLT1B Gene

Sources for GOLT1B Gene

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