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Aliases for GOLT1A Gene

Aliases for GOLT1A Gene

  • Golgi Transport 1A 2 3 5
  • HGOT1b 3 4
  • Golgi Transport 1 Homolog A (S. Cerevisiae) 2
  • Vesicle Transport Protein GOT1A 3
  • Golgi Transport 1 Homolog A 4
  • HMFN1187 3
  • CGI-141 3
  • YMR292W 3
  • GOT1B 4
  • GOT1 3

External Ids for GOLT1A Gene

Previous GeneCards Identifiers for GOLT1A Gene

  • GC01M200899
  • GC01M202433
  • GC01M204167
  • GC01M175332

Summaries for GOLT1A Gene

GeneCards Summary for GOLT1A Gene

GOLT1A (Golgi Transport 1A) is a Protein Coding gene. GO annotations related to this gene include lipase activity. An important paralog of this gene is GOLT1B.

UniProtKB/Swiss-Prot for GOLT1A Gene

  • May be involved in fusion of ER-derived transport vesicles with the Golgi complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLT1A Gene

Genomics for GOLT1A Gene

Regulatory Elements for GOLT1A Gene

Enhancers for GOLT1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F204281 0.7 Ensembl ENCODE 16.5 -69.3 -69329 2.9 SP5 DMAP1 REST ZIC2 ZGPAT SMARCA4 GABPB1 PRDM1 GOLT1A ETNK2 LOC101929441 ENSG00000231691 RPL21P19
GH01F204285 0.9 FANTOM5 Ensembl ENCODE 15.5 -73.6 -73559 4.3 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 ZNF48 YY1 GOLT1A PLEKHA6 ETNK2 LOC101929441 PIK3C2B ENSG00000231691 RPL21P19
GH01F204171 0.5 Ensembl ENCODE 12.1 +41.9 41918 1.6 RARA FOS ZBTB11 CEBPB ZNF592 CREB3 MEF2D ZNF589 GLIS1 CEBPA GOLT1A LOC101929441 PRELP REN ENSG00000231691 PLEKHA6 PIK3C2B ATP2B4 ENSG00000225522 GC01M204154
GH01F204170 0.4 ENCODE 12.1 +43.1 43085 0.2 GOLT1A LOC101929441 ENSG00000231691 PLEKHA6 ENSG00000225522 GC01M204154
GH01F204361 1.1 FANTOM5 Ensembl ENCODE 11.5 -149.0 -148992 3.9 HDGF ATF1 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A ZNF2 GLIS2 PPP1R15B ENSG00000231691 GOLT1A ETNK2 LOC101929441 PLEKHA6 SOX13 LINC00628 RPL21P19
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GOLT1A on UCSC Golden Path with GeneCards custom track

Promoters for GOLT1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082247 -108 401 ATF1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 SP5 NFYC ZHX2
ENSR00001753667 392 201 TFAP4 MXI1 MTA2 SAP130 ARID4B MXD4 DMAP1 PPARG EP300 ATF4

Genomic Location for GOLT1A Gene

Chromosome:
1
Start:
204,198,160 bp from pter
End:
204,214,092 bp from pter
Size:
15,933 bases
Orientation:
Minus strand

Genomic View for GOLT1A Gene

Genes around GOLT1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLT1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLT1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLT1A Gene

Proteins for GOLT1A Gene

  • Protein details for GOLT1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVE7-GOT1A_HUMAN
    Recommended name:
    Vesicle transport protein GOT1A
    Protein Accession:
    Q6ZVE7

    Protein attributes for GOLT1A Gene

    Size:
    132 amino acids
    Molecular mass:
    14887 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GOLT1A Gene

Post-translational modifications for GOLT1A Gene

No Post-translational modifications

Other Protein References for GOLT1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GOLT1A Gene

Domains & Families for GOLT1A Gene

Protein Domains for GOLT1A Gene

Suggested Antigen Peptide Sequences for GOLT1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZVE7

UniProtKB/Swiss-Prot:

GOT1A_HUMAN :
  • Belongs to the GOT1 family.
Family:
  • Belongs to the GOT1 family.
genes like me logo Genes that share domains with GOLT1A: view

No data available for Gene Families for GOLT1A Gene

Function for GOLT1A Gene

Molecular function for GOLT1A Gene

UniProtKB/Swiss-Prot Function:
May be involved in fusion of ER-derived transport vesicles with the Golgi complex.

Phenotypes for GOLT1A Gene

GenomeRNAi human phenotypes for GOLT1A:
genes like me logo Genes that share phenotypes with GOLT1A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLT1A Gene

Localization for GOLT1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLT1A Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GOLT1A Gene COMPARTMENTS Subcellular localization image for GOLT1A gene
Compartment Confidence
golgi apparatus 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GOLT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GOLT1A: view

Pathways & Interactions for GOLT1A Gene

SuperPathways for GOLT1A Gene

No Data Available

Gene Ontology (GO) - Biological Process for GOLT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with GOLT1A: view

No data available for Pathways by source and SIGNOR curated interactions for GOLT1A Gene

Transcripts for GOLT1A Gene

mRNA/cDNA for GOLT1A Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(42) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GOLT1A Gene

Golgi transport 1A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOLT1A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: - -
SP2: - -
SP3: -
SP4:

Relevant External Links for GOLT1A Gene

GeneLoc Exon Structure for
GOLT1A
ECgene alternative splicing isoforms for
GOLT1A

Expression for GOLT1A Gene

mRNA expression in normal human tissues for GOLT1A Gene

mRNA differential expression in normal tissues according to GTEx for GOLT1A Gene

This gene is overexpressed in Liver (x23.3) and Pituitary (x4.4).

Protein differential expression in normal tissues from HIPED for GOLT1A Gene

This gene is overexpressed in Liver (60.1) and Heart (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GOLT1A Gene



Protein tissue co-expression partners for GOLT1A Gene

NURSA nuclear receptor signaling pathways regulating expression of GOLT1A Gene:

GOLT1A

SOURCE GeneReport for Unigene cluster for GOLT1A Gene:

Hs.532401
genes like me logo Genes that share expression patterns with GOLT1A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GOLT1A Gene

Orthologs for GOLT1A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GOLT1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOLT1A 34 35
  • 98.56 (n)
cow
(Bos Taurus)
Mammalia GOLT1A 34 35
  • 87.37 (n)
dog
(Canis familiaris)
Mammalia GOLT1A 34 35
  • 86.93 (n)
mouse
(Mus musculus)
Mammalia GOLT1A 35
  • 86 (a)
OneToMany
Golt1a 34 16 35
  • 83.33 (n)
rat
(Rattus norvegicus)
Mammalia Golt1a 34
  • 84.1 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GOLT1A 35
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GOLT1A 35
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GOLT1A 35
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii GOLT1A 35
  • 68 (a)
OneToOne
LOC100001834 34
  • 65.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32576 35
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F41C3.4 35
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GOT1 35
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5537 35
  • 54 (a)
OneToMany
Species where no ortholog for GOLT1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GOLT1A Gene

ENSEMBL:
Gene Tree for GOLT1A (if available)
TreeFam:
Gene Tree for GOLT1A (if available)

Paralogs for GOLT1A Gene

Paralogs for GOLT1A Gene

(1) SIMAP similar genes for GOLT1A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GOLT1A: view

Variants for GOLT1A Gene

Sequence variations from dbSNP and Humsavar for GOLT1A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10900559 -- 204,211,412(+) AGCCC(C/T)CTTGA intron-variant
rs10900560 -- 204,211,498(+) ATCAT(A/T)CAGGT intron-variant
rs111232500 -- 204,199,997(+) CTGAG(G/T)TCCCT intron-variant
rs111311110 -- 204,201,930(+) CATCT(A/G)AGCGA intron-variant
rs111392155 -- 204,201,374(+) GGCCT(C/T)GTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GOLT1A Gene

Variant ID Type Subtype PubMed ID
esv2477162 CNV deletion 19546169
esv2762138 CNV gain 21179565
esv3545444 CNV deletion 23714750
esv3588614 CNV gain 21293372
esv3588615 CNV gain 21293372
nsv1007228 CNV gain 25217958
nsv1137841 CNV deletion 24896259
nsv549039 CNV gain 21841781

Variation tolerance for GOLT1A Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GOLT1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLT1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLT1A Gene

Disorders for GOLT1A Gene

Relevant External Links for GOLT1A

Genetic Association Database (GAD)
GOLT1A
Human Genome Epidemiology (HuGE) Navigator
GOLT1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GOLT1A

No disorders were found for GOLT1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOLT1A Gene

Publications for GOLT1A Gene

  1. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3 46 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for GOLT1A Gene

Sources for GOLT1A Gene

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