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Aliases for GOLT1A Gene

Aliases for GOLT1A Gene

  • Golgi Transport 1A 2 3 5
  • HGOT1b 3 4
  • Golgi Transport 1 Homolog A (S. Cerevisiae) 2
  • Vesicle Transport Protein GOT1A 3
  • Golgi Transport 1 Homolog A 4
  • HMFN1187 3
  • CGI-141 3
  • YMR292W 3
  • GOT1B 4
  • GOT1 3

External Ids for GOLT1A Gene

Previous GeneCards Identifiers for GOLT1A Gene

  • GC01M200899
  • GC01M202433
  • GC01M204167
  • GC01M175332

Summaries for GOLT1A Gene

GeneCards Summary for GOLT1A Gene

GOLT1A (Golgi Transport 1A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include lipase activity. An important paralog of this gene is GOLT1B.

UniProtKB/Swiss-Prot for GOLT1A Gene

  • May be involved in fusion of ER-derived transport vesicles with the Golgi complex.

Additional gene information for GOLT1A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLT1A Gene

Genomics for GOLT1A Gene

GeneHancer (GH) Regulatory Elements for GOLT1A Gene

Promoters and enhancers for GOLT1A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I204210 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.8 +1.3 1337 4.1 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ETS1 SLC30A9 ZNF143 GOLT1A PLEKHA6 ETNK2 ENSG00000231691 LOC100420418
GH01I204285 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.5 -73.6 -73559 4.3 HDGF PKNOX1 CLOCK ATF1 ARID4B NEUROD1 SIN3A FEZF1 ZNF2 ZBTB7B PLEKHA6 GOLT1A ETNK2 ERLNC1 PIK3C2B ENSG00000231691 GC01P204254 RPL21P19
GH01I204361 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -149.0 -148992 3.9 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A ZNF2 ZBTB7B IRF4 ZC3H11A PPP1R15B MDM4 ENSG00000231691 GOLT1A ETNK2 ERLNC1 PLEKHA6 SOX13 LINC00628
GH01I204376 Promoter/Enhancer 1.9 Ensembl ENCODE dbSUPER 9.9 -165.8 -165778 6.6 PKNOX1 CLOCK ZFP64 ARID4B NEUROD1 SIN3A DMAP1 IRF4 ZNF48 YY1 PPP1R15B ZC3H11A MDM4 ENSG00000240219 ENSG00000231691 ETNK2 ERLNC1 PIK3C2B GOLT1A SOX13
GH01I204292 Enhancer 1.5 VISTA Ensembl ENCODE dbSUPER 10.6 -81.0 -80980 6 ARID4B BRCA1 RAD21 RARA RFX5 GTF3C2 POLR3A SMARCC2 RCOR1 FOS PLEKHA6 RBBP5 GOLT1A ETNK2 ENSG00000231691 GC01P204254 RPL21P19
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GOLT1A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GOLT1A gene promoter:

Genomic Locations for GOLT1A Gene

Genomic Locations for GOLT1A Gene
15,933 bases
Minus strand

Genomic View for GOLT1A Gene

Genes around GOLT1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLT1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLT1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLT1A Gene

Proteins for GOLT1A Gene

  • Protein details for GOLT1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vesicle transport protein GOT1A
    Protein Accession:

    Protein attributes for GOLT1A Gene

    132 amino acids
    Molecular mass:
    14887 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GOLT1A Gene

Post-translational modifications for GOLT1A Gene

No Post-translational modifications

Other Protein References for GOLT1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GOLT1A Gene

Domains & Families for GOLT1A Gene

Gene Families for GOLT1A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for GOLT1A Gene

Suggested Antigen Peptide Sequences for GOLT1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GOT1 family.
  • Belongs to the GOT1 family.
genes like me logo Genes that share domains with GOLT1A: view

Function for GOLT1A Gene

Molecular function for GOLT1A Gene

UniProtKB/Swiss-Prot Function:
May be involved in fusion of ER-derived transport vesicles with the Golgi complex.

Gene Ontology (GO) - Molecular Function for GOLT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with GOLT1A: view

Phenotypes for GOLT1A Gene

GenomeRNAi human phenotypes for GOLT1A:
genes like me logo Genes that share phenotypes with GOLT1A: view

Animal Model Products

CRISPR Products

miRNA for GOLT1A Gene

miRTarBase miRNAs that target GOLT1A

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLT1A Gene

Localization for GOLT1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLT1A Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLT1A gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GOLT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000137 Golgi cis cisterna IDA 10406798
GO:0000139 Golgi membrane IEA --
GO:0005635 nuclear envelope IDA 10406798
GO:0005783 endoplasmic reticulum IDA 10406798
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with GOLT1A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GOLT1A Gene

Pathways & Interactions for GOLT1A Gene

SuperPathways for GOLT1A Gene

No Data Available

Interacting Proteins for GOLT1A Gene

Gene Ontology (GO) - Biological Process for GOLT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport ISS 10406798
GO:0008150 biological_process ND --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with GOLT1A: view

No data available for Pathways by source and SIGNOR curated interactions for GOLT1A Gene

Drugs & Compounds for GOLT1A Gene

No Compound Related Data Available

Transcripts for GOLT1A Gene

mRNA/cDNA for GOLT1A Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(42) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GOLT1A Gene

Golgi transport 1A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOLT1A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: - -
SP2: - -
SP3: -

Relevant External Links for GOLT1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GOLT1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GOLT1A Gene

mRNA differential expression in normal tissues according to GTEx for GOLT1A Gene

This gene is overexpressed in Liver (x23.3) and Pituitary (x4.4).

Protein differential expression in normal tissues from HIPED for GOLT1A Gene

This gene is overexpressed in Liver (60.1) and Heart (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GOLT1A Gene

Protein tissue co-expression partners for GOLT1A Gene

NURSA nuclear receptor signaling pathways regulating expression of GOLT1A Gene:


SOURCE GeneReport for Unigene cluster for GOLT1A Gene:

genes like me logo Genes that share expression patterns with GOLT1A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLT1A Gene

Orthologs for GOLT1A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GOLT1A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GOLT1A 33 34
  • 98.56 (n)
(Bos Taurus)
Mammalia GOLT1A 33 34
  • 87.37 (n)
(Canis familiaris)
Mammalia GOLT1A 33 34
  • 86.93 (n)
(Mus musculus)
Mammalia GOLT1A 34
  • 86 (a)
Golt1a 33 16 34
  • 83.33 (n)
(Rattus norvegicus)
Mammalia Golt1a 33
  • 84.1 (n)
(Ornithorhynchus anatinus)
Mammalia GOLT1A 34
  • 71 (a)
(Monodelphis domestica)
Mammalia GOLT1A 34
  • 66 (a)
(Anolis carolinensis)
Reptilia GOLT1A 34
  • 68 (a)
(Danio rerio)
Actinopterygii GOLT1A 34
  • 68 (a)
LOC100001834 33
  • 65.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32576 34
  • 52 (a)
(Caenorhabditis elegans)
Secernentea F41C3.4 34
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GOT1 34
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5537 34
  • 54 (a)
Species where no ortholog for GOLT1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GOLT1A Gene

Gene Tree for GOLT1A (if available)
Gene Tree for GOLT1A (if available)

Paralogs for GOLT1A Gene

Paralogs for GOLT1A Gene

(1) SIMAP similar genes for GOLT1A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GOLT1A: view

Variants for GOLT1A Gene

Sequence variations from dbSNP and Humsavar for GOLT1A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000497746 -- 204,213,482(-) A/G intron_variant
rs1000550081 -- 204,213,232(-) C/A intron_variant
rs1000783564 -- 204,206,375(-) C/G intron_variant
rs1000984642 -- 204,201,049(-) C/T intron_variant
rs1001447992 -- 204,205,658(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GOLT1A Gene

Variant ID Type Subtype PubMed ID
esv2477162 CNV deletion 19546169
esv2762138 CNV gain 21179565
esv3545444 CNV deletion 23714750
esv3588614 CNV gain 21293372
esv3588615 CNV gain 21293372
nsv1007228 CNV gain 25217958
nsv1137841 CNV deletion 24896259
nsv549039 CNV gain 21841781

Variation tolerance for GOLT1A Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GOLT1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLT1A Gene

Disorders for GOLT1A Gene

Additional Disease Information for GOLT1A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GOLT1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOLT1A Gene

Publications for GOLT1A Gene

  1. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret GB … Chakravarti A (European journal of human genetics : EJHG 2009) 3 44 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58

Products for GOLT1A Gene

Sources for GOLT1A Gene

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