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Aliases for GOLT1A Gene

Aliases for GOLT1A Gene

  • Golgi Transport 1A 2 3
  • HGOT1b 3 4
  • Golgi Transport 1 Homolog A (S. Cerevisiae) 2
  • Putative Protein Product Of HMFN1187 3
  • Golgi Transport 1 Homolog A 4
  • HMFN1187 3
  • CGI-141 3
  • YMR292W 3
  • GOT1B 4
  • GOT1 3

External Ids for GOLT1A Gene

Previous GeneCards Identifiers for GOLT1A Gene

  • GC01M200899
  • GC01M202433
  • GC01M204167
  • GC01M175332

Summaries for GOLT1A Gene

GeneCards Summary for GOLT1A Gene

GOLT1A (Golgi Transport 1A) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include lipase activity. An important paralog of this gene is GOLT1B.

UniProtKB/Swiss-Prot for GOLT1A Gene

  • May be involved in fusion of ER-derived transport vesicles with the Golgi complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLT1A Gene

Genomics for GOLT1A Gene

Genomic Location for GOLT1A Gene

Chromosome:
1
Start:
204,198,160 bp from pter
End:
204,214,092 bp from pter
Size:
15,933 bases
Orientation:
Minus strand

Genomic View for GOLT1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GOLT1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLT1A Gene

Proteins for GOLT1A Gene

  • Protein details for GOLT1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVE7-GOT1A_HUMAN
    Recommended name:
    Vesicle transport protein GOT1A
    Protein Accession:
    Q6ZVE7

    Protein attributes for GOLT1A Gene

    Size:
    132 amino acids
    Molecular mass:
    14887 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GOLT1A Gene

Proteomics data for GOLT1A Gene at MOPED

Post-translational modifications for GOLT1A Gene

No Post-translational modifications

Other Protein References for GOLT1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GOLT1A Gene

Domains & Families for GOLT1A Gene

Protein Domains for GOLT1A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GOLT1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZVE7

UniProtKB/Swiss-Prot:

GOT1A_HUMAN :
  • Belongs to the GOT1 family.
Family:
  • Belongs to the GOT1 family.
genes like me logo Genes that share domains with GOLT1A: view

No data available for Gene Families for GOLT1A Gene

Function for GOLT1A Gene

Molecular function for GOLT1A Gene

UniProtKB/Swiss-Prot Function:
May be involved in fusion of ER-derived transport vesicles with the Golgi complex.

Gene Ontology (GO) - Molecular Function for GOLT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016298 lipase activity IBA --
genes like me logo Genes that share ontologies with GOLT1A: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLT1A Gene

Localization for GOLT1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLT1A Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GOLT1A Gene COMPARTMENTS Subcellular localization image for GOLT1A gene
Compartment Confidence
golgi apparatus 3

Gene Ontology (GO) - Cellular Components for GOLT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0098588 bounding membrane of organelle IBA --
genes like me logo Genes that share ontologies with GOLT1A: view

Pathways & Interactions for GOLT1A Gene

genes like me logo Genes that share pathways with GOLT1A: view

Interacting Proteins for GOLT1A Gene

Gene Ontology (GO) - Biological Process for GOLT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IBA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with GOLT1A: view

No data available for SIGNOR curated interactions for GOLT1A Gene

Drugs & Compounds for GOLT1A Gene

No Compound Related Data Available

Transcripts for GOLT1A Gene

mRNA/cDNA for GOLT1A Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(42) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GOLT1A Gene

Golgi transport 1A:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GOLT1A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOLT1A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: - -
SP2: - -
SP3: -
SP4:

Relevant External Links for GOLT1A Gene

GeneLoc Exon Structure for
GOLT1A
ECgene alternative splicing isoforms for
GOLT1A

Expression for GOLT1A Gene

mRNA expression in normal human tissues for GOLT1A Gene

mRNA differential expression in normal tissues according to GTEx for GOLT1A Gene

This gene is overexpressed in Liver (x23.3) and Pituitary (x4.4).

Protein differential expression in normal tissues from HIPED for GOLT1A Gene

This gene is overexpressed in Liver (60.1) and Heart (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GOLT1A Gene



SOURCE GeneReport for Unigene cluster for GOLT1A Gene Hs.532401

genes like me logo Genes that share expression patterns with GOLT1A: view

Protein tissue co-expression partners for GOLT1A Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GOLT1A Gene

Orthologs for GOLT1A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GOLT1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GOLT1A 35
  • 87.37 (n)
  • 90.15 (a)
GOLT1A 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GOLT1A 35
  • 86.93 (n)
  • 88 (a)
GOLT1A 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Golt1a 35
  • 83.33 (n)
  • 86.15 (a)
Golt1a 16
Golt1a 36
  • 86 (a)
OneToMany
GOLT1A 36
  • 86 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia GOLT1A 35
  • 98.56 (n)
  • 98.28 (a)
GOLT1A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Golt1a 35
  • 84.1 (n)
  • 88.46 (a)
oppossum
(Monodelphis domestica)
Mammalia GOLT1A 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GOLT1A 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GOLT1A 36
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100001834 35
  • 65.91 (n)
  • 68.94 (a)
GOLT1A 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32576 36
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F41C3.4 36
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GOT1 36
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5537 36
  • 54 (a)
OneToMany
Species with no ortholog for GOLT1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GOLT1A Gene

ENSEMBL:
Gene Tree for GOLT1A (if available)
TreeFam:
Gene Tree for GOLT1A (if available)

Paralogs for GOLT1A Gene

Paralogs for GOLT1A Gene

(1) SIMAP similar genes for GOLT1A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GOLT1A: view

Variants for GOLT1A Gene

Sequence variations from dbSNP and Humsavar for GOLT1A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs13334 -- 204,202,962(+) ATGCC(A/G/T)AAACC reference, synonymous-codon
rs3795573 -- 204,198,544(-) ATTGC(A/G)TCTGC intron-variant
rs4373805 -- 204,206,451(+) ACAAC(A/G)CATTG intron-variant
rs4520474 -- 204,206,755(+) CATCC(C/T)GCACA intron-variant
rs4534452 -- 204,216,056(+) TGATC(A/G)GAACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GOLT1A Gene

Variant ID Type Subtype PubMed ID
esv2477162 CNV Deletion 19546169

Variation tolerance for GOLT1A Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GOLT1A Gene

HapMap Linkage Disequilibrium report
GOLT1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLT1A Gene

Disorders for GOLT1A Gene

Relevant External Links for GOLT1A

Genetic Association Database (GAD)
GOLT1A
Human Genome Epidemiology (HuGE) Navigator
GOLT1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GOLT1A
genes like me logo Genes that share disorders with GOLT1A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOLT1A Gene

Publications for GOLT1A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 67
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 67
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for GOLT1A Gene

Sources for GOLT1A Gene

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