GOLPH3L Gene

Aliases
for GOLPH3L gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC01M147432 GC01M148885 GC01M121996

Summaries
for GOLPH3L gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for GOLPH3L gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000001.10  NT_004487.20  NC_018912.2  

SwitchGear Promoter luciferase reporter plasmid: GOLPH3L promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GOLPH3L

GOLPH3L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M150618:  view genomic region     (about GC identifiers)

Proteins
for GOLPH3L gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for GOLPH3L: NX_Q9H4A5

Explore proteomics data for GOLPH3L at MOPED

Post-translational modifications: 

GOLPH3L Human Recombinant Protein Products:

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	antibodies-online peptides for GOLPH3L

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	antibodies-online kits for GOLPH3L (8 products)

Domains /
Families
for GOLPH3L gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9H4A5

Find genes that share domains with GOLPH3L           About GenesLikeMe

Function
for GOLPH3L gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for GOLPH3L

miRNA Products:		miRTarBase miRNAs that target GOLPH3L: hsa-mir-15a-5p (MIRT000849), hsa-mir-16-5p (MIRT000848), hsa-mir-128-3p (MIRT022020)
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		Selected qRT-PCR Assays for microRNAs that regulate GOLPH3L (see all 32):
		hsa-miR-3074-3p hsa-miR-449a hsa-miR-3921 hsa-miR-29b-1* hsa-miR-570 hsa-miR-29a* hsa-miR-23a hsa-miR-761
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Gene Editing Products:

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOLPH3L

Localization
for GOLPH3L gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
golgi apparatus	5
nucleus	3

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Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for GOLPH3L gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for GOLPH3L About     See pathways by source

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	SuperPath	Contained pathways About
1	Transcriptional misregulation in cancer	Transcriptional misregulation in cancer

1 Kegg Pathway  (Kegg details for GOLPH3L)

Transcriptional misregulation in cancer

Gene Ontology (GO): 2 biological process terms:    About this table

Drugs & Compounds
for GOLPH3L gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for GOLPH3L gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for GOLPH3L gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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GOLPH3L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AATTGAAACC

About this image

Eye (Sensory Organs)
Retina

Primer Products:		OriGene qPCR primer pairs and template standards for GOLPH3L OriGene qSTAR qPCR primer pairs in human, mouse for GOLPH3L
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOLPH3L

Orthologs
for GOLPH3L gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for GOLPH3L gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for GOLPH3L gene

GOLPH3²  

1 SIMAP similar gene for GOLPH3L using alignment to 3 protein entries:     GLP3L_HUMAN     F5H4M3_HUMAN     Q5T5I6_HUMAN(see first protein):

GOLPH3

Find genes that share paralogs with GOLPH3L           About GenesLikeMe

Genomic Variants
for GOLPH3L gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for GOLPH3L (see all 872)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs710865891,2	C	--	150625932(+)	TTTTT-/TGGAGA	1	--	int1		1		NA	2
rs120585481,2	A	--	150666273(+)	TATGTA/GTGTGT	1	--	int1		0	--	--	--	--
rs112047031,2	C,A	--	150666297(+)	TGTGTG/ATATAT	1	--	int1		3		NA	6
rs1906257571,2		--	150666299(+)	TGTATA/GTATAT	1	--	int1		0	--	--	--	--
rs117997141,2	H	--	150666311(+)	tatatA/Gtatat	1	--	int1		0	--	--	--	--
rs127317121,2		--	150666316(+)	atataC/Tatata	1	--	int1		0	--	--	--	--
rs666273721,2	C	--	150666324(+)	TATAT-/TT/TT   T/TTTTTTTTTT	2	--	int1 cds1		2		NA	4
rs75564891,2	C	--	150666325(+)	tatatA/Tttttt	1	--	int1 trp3		1		NA	2
rs117997271,2	C,F,H	--	150666379(+)	catccG/Aggctg	1	--	int1		1		NA	2
rs1409840021,2		--	157119935(+)	AATTGA/GCTAAT	1	--	ds5001		0	--	--	--	--

HapMap Linkage Disequilibrium report for GOLPH3L (150618701 - 150669672 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for GOLPH3L:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2427260	CNV	Deletion	19546169
nsv437158	CNV	Loss	16327808
nsv872417	CNV	Loss	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing GOLPH3L

DNA2.0 Custom Variant and Variant Library Synthesis for GOLPH3L

Disorders / Diseases
for GOLPH3L gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for GOLPH3L gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. GOLPH3L antagonizes GOLPH3 to determine Golgi morphology. (PubMed id 23345592)^{1, 2} Ng M.M....Field S.J. (Mol. Biol. Cell 2013)
2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
4. Proteomics characterization of abundant Golgi membrane proteins. (PubMed id 11042173)^{1, 2} Bell A.W....Bergeron J.J.M. (J. Biol. Chem. 2001)
5. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)¹ Yu C.C....Chow L.P. (PLoS ONE 2013)
6. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)¹ Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
7. Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment. (PubMed id 23585552)¹ Kirin M....Mitry D. (Hum. Mol. Genet. 2013)
8. A conserved N-terminal arginine-motif in GOLPH3-family proteins mediates binding to coatomer. (PubMed id 22889169)² Tu L.... Banfield D.K. (Traffic 2012)
9. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (Mol. Cell 2011)

External Searches for GOLPH3L gene

Genome Databases showing GOLPH3L gene

Other Databases showing GOLPH3L gene

Specialized Databases showing GOLPH3L gene

Products
for GOLPH3L gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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