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GOLPH3L Gene(Protein Coding)

Golgi Phosphoprotein 3 Like

GCID:
GC01M150618
GIFtS:
52
Genes Participants
UDN Logo

Aliases for GOLPH3L Gene

Aliases for GOLPH3L Gene

  • Golgi Phosphoprotein 3 Like 2 3
  • Golgi Phosphoprotein 3-Like 2 5
  • GPP34-Related Protein 3 4
  • GPP34R 3 4

External Ids for GOLPH3L Gene

Previous GeneCards Identifiers for GOLPH3L Gene

  • GC01M147432
  • GC01M148885
  • GC01M121996

Summaries for GOLPH3L Gene

Entrez Gene Summary for GOLPH3L Gene

  • The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is localized at the Golgi stack and may have a regulatory role in Golgi trafficking. [provided by RefSeq, Jul 2008]

GeneCards Summary for GOLPH3L Gene

GOLPH3L (Golgi Phosphoprotein 3 Like) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include phosphatidylinositol-4-phosphate binding. An important paralog of this gene is GOLPH3.

UniProtKB/Swiss-Prot for GOLPH3L Gene

  • Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLPH3L Gene

Genomics for GOLPH3L Gene

Products:

  1. Regulatory Element

Regulatory Elements for GOLPH3L Gene

Enhancers for GOLPH3L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GOLPH3L on UCSC Golden Path with GeneCards custom track

Promoters for GOLPH3L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GOLPH3L on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the GOLPH3L gene promoter:

Genomic Location for GOLPH3L Gene

Chromosome:
1
Start:
150,646,225 bp from pter
End:
150,697,956 bp from pter
Size:
51,732 bases
Orientation:
Minus strand

Genomic View for GOLPH3L Gene

Genes around GOLPH3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLPH3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLPH3L Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GOLPH3L Gene

Proteins for GOLPH3L Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GOLPH3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4A5-GLP3L_HUMAN
    Recommended name:
    Golgi phosphoprotein 3-like
    Protein Accession:
    Q9H4A5
    Secondary Accessions:
    • B1AN09
    • B7Z6N3
    • Q9NVK0

    Protein attributes for GOLPH3L Gene

    Size:
    285 amino acids
    Molecular mass:
    32767 Da
    Quaternary structure:
    • Homooligomer (By similarity). Does not interact MYO18; differs from GOLPH3 by its inability to interact with MYO18. May interact with ARF1.
    SequenceCaution:
    • Sequence=BAA91750.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for GOLPH3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOLPH3L Gene

Proteomics data for GOLPH3L Gene at MOPED

Protein Expression for GOLPH3L Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GOLPH3L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GOLPH3L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GOLPH3L Gene

Domains & Families for GOLPH3L Gene

Protein Domains for GOLPH3L Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GOLPH3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H4A5

UniProtKB/Swiss-Prot:

GLP3L_HUMAN :
  • Belongs to the GOLPH3/VPS74 family.
Family:
  • Belongs to the GOLPH3/VPS74 family.
genes like me logo Genes that share domains with GOLPH3L: view

No data available for Gene Families for GOLPH3L Gene

Function for GOLPH3L Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for GOLPH3L Gene

UniProtKB/Swiss-Prot Function:
Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane.

Phenotypes for GOLPH3L Gene

GenomeRNAi human phenotypes for GOLPH3L:
genes like me logo Genes that share phenotypes with GOLPH3L: view

Animal Model Products

CRISPR Products

miRNA for GOLPH3L Gene

miRTarBase miRNAs that target GOLPH3L

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLPH3L Gene

Localization for GOLPH3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLPH3L Gene

Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Note=Phosphatidylinositol 4-phosphate (PtdIns4P)-binding mediates recruitment to Golgi membranes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GOLPH3L Gene COMPARTMENTS Subcellular localization image for GOLPH3L gene
Compartment Confidence
golgi apparatus 4
nucleus 4
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for GOLPH3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0032588 trans-Golgi network membrane IC 23345592
genes like me logo Genes that share ontologies with GOLPH3L: view

Pathways & Interactions for GOLPH3L Gene

genes like me logo Genes that share pathways with GOLPH3L: view

Pathways by source for GOLPH3L Gene

1 KEGG pathway for GOLPH3L Gene

Gene Ontology (GO) - Biological Process for GOLPH3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IMP 23345592
genes like me logo Genes that share ontologies with GOLPH3L: view

No data available for SIGNOR curated interactions for GOLPH3L Gene

Drugs & Compounds for GOLPH3L Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for GOLPH3L Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for GOLPH3L Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(156) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GOLPH3L Gene

Golgi phosphoprotein 3-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOLPH3L Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - - -
SP6: - - - - -
SP7: -

Relevant External Links for GOLPH3L Gene

GeneLoc Exon Structure for
GOLPH3L
ECgene alternative splicing isoforms for
GOLPH3L

Expression for GOLPH3L Gene

Products:

  1. Primer

mRNA expression in normal human tissues for GOLPH3L Gene

mRNA expression in normal human tissues for GOLPH3L Gene
mRNA expression by BioGPS for GOLPH3L GenemRNA expression by GTEx for GOLPH3L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GOLPH3L Gene

This gene is overexpressed in Nasal epithelium (19.2), Skin (9.1), Oral epithelium (7.3), and Salivary gland (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GOLPH3L Gene



SOURCE GeneReport for Unigene cluster for GOLPH3L Gene Hs.203699

genes like me logo Genes that share expression patterns with GOLPH3L: view

Protein tissue co-expression partners for GOLPH3L Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GOLPH3L Gene

Orthologs for GOLPH3L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GOLPH3L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia GOLPH3L 35
  • 92.63 (n)
  • 95.44 (a)
GOLPH3L 36
  • 95 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia GOLPH3L 35
  • 93.33 (n)
  • 95.44 (a)
GOLPH3L 36
  • 95 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Golph3l 35
  • 89.59 (n)
  • 95.09 (a)
Golph3l 16
Golph3l 36
  • 79 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia GOLPH3L 35
  • 99.65 (n)
  • 100 (a)
GOLPH3L 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Golph3l 35
  • 89.94 (n)
  • 94.74 (a)
oppossum
(Monodelphis domestica)
 Mammalia GOLPH3L 36
  • 89 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia GOLPH3L 36
  • 65 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves GOLPH3L 35
  • 68.22 (n)
  • 72.4 (a)
GOLPH3L 36
  • 69 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia GOLPH3L 36
  • 84 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia golph3l 35
  • 73.21 (n)
  • 81.07 (a)
zebrafish
(Danio rerio)
 Actinopterygii golph3l 35
  • 63.5 (n)
  • 63.73 (a)
golph3l 36
  • 60 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta l(2)s5379 36
  • 59 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea Y47G6A.18 36
  • 54 (a)
 OneToMany
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_ACL165C 35
  • 53.86 (n)
  • 50.46 (a)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0E02355g 35
  • 53.99 (n)
  • 49.3 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes VPS74 35
  • 53.62 (n)
  • 50.47 (a)
VPS74 36
  • 33 (a)
 OneToMany
bread mold
(Neurospora crassa)
 Ascomycetes NCU06091 35
  • 52.17 (n)
  • 49.33 (a)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes SPAC5D6.13 35
  • 53.86 (n)
  • 50.46 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.486 36
  • 53 (a)
 OneToMany
Species with no ortholog for GOLPH3L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GOLPH3L Gene

ENSEMBL:
Gene Tree for GOLPH3L (if available)
TreeFam:
Gene Tree for GOLPH3L (if available)

Paralogs for GOLPH3L Gene

Paralogs for GOLPH3L Gene

(1) SIMAP similar genes for GOLPH3L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GOLPH3L: view

Variants for GOLPH3L Gene

Sequence variations from dbSNP and Humsavar for GOLPH3L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs9733 -- 150,646,485(-) TCTCT(A/C)ACTGA utr-variant-3-prime
rs868751 -- 150,696,938(-) AAAAA(A/C)CCTCT intron-variant, upstream-variant-2KB
rs1151917 -- 150,650,220(+) GGTCT(A/T)AAGCA intron-variant
rs1241574 -- 150,670,940(+) ttttg(C/T)tatta intron-variant
rs1241575 -- 150,673,896(+) ctcca(A/T)cctgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GOLPH3L Gene

Variant ID Type Subtype PubMed ID
nsv872417 CNV Loss 21882294
esv2427260 CNV Deletion 19546169
nsv437158 CNV Loss 16327808

Variation tolerance for GOLPH3L Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GOLPH3L Gene

Disorders for GOLPH3L Gene

Relevant External Links for GOLPH3L

Genetic Association Database (GAD)
GOLPH3L
Human Genome Epidemiology (HuGE) Navigator
GOLPH3L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GOLPH3L

No disorders were found for GOLPH3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOLPH3L Gene

Publications for GOLPH3L Gene

  1. GOLPH3L antagonizes GOLPH3 to determine Golgi morphology. (PMID: 23345592) Ng M.M. … Field S.J. (Mol. Biol. Cell 2013) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  4. A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. (PMID: 25217961) Al Olama A.A. … Haiman C.A. (Nat. Genet. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for GOLPH3L Gene

Sources for GOLPH3L Gene

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