Aliases for GOLPH3L Gene
Aliases for GOLPH3L Gene
External Ids for GOLPH3L Gene
- HGNC: 24882
- Entrez Gene: 55204
- Ensembl: ENSG00000143457
- OMIM: 612208
- UniProtKB: Q9H4A5
Previous GeneCards Identifiers for GOLPH3L Gene
- GC01M147432
- GC01M148885
- GC01M150618
- GC01M121996
Summaries for GOLPH3L Gene
-
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is localized at the Golgi stack and may have a regulatory role in Golgi trafficking. [provided by RefSeq, Jul 2008]
GeneCards Summary for GOLPH3L Gene
GOLPH3L (Golgi Phosphoprotein 3 Like) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include phosphatidylinositol-4-phosphate binding. An important paralog of this gene is GOLPH3.
UniProtKB/Swiss-Prot for GOLPH3L Gene
-
Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLPH3L Gene
Genomics for GOLPH3L Gene
Regulatory Elements for GOLPH3L Gene
Enhancers for GOLPH3L Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around GOLPH3L on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the GOLPH3L gene promoter:
Regulatory Element Products
Genomic Location for GOLPH3L Gene
- Chromosome:
- 1
- Start:
- 150,646,225 bp from pter
- End:
- 150,697,956 bp from pter
- Size:
- 51,732 bases
- Orientation:
- Minus strand
Genomic View for GOLPH3L Gene
Genes around GOLPH3L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.3 by Ensembl
- 1q21.3 by Entrez Gene
- 1q21.3 by HGNC
GOLPH3L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GOLPH3L Gene
Proteins for GOLPH3L Gene
-
Protein details for GOLPH3L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H4A5-GLP3L_HUMAN
- Recommended name:
- Golgi phosphoprotein 3-like
- Protein Accession:
- Q9H4A5
- B1AN09
- B7Z6N3
- Q9NVK0
Protein attributes for GOLPH3L Gene
- Size:
- 285 amino acids
- Molecular mass:
- 32767 Da
- Quaternary structure:
-
- Homooligomer (By similarity). Does not interact MYO18; differs from GOLPH3 by its inability to interact with MYO18. May interact with ARF1.
- SequenceCaution:
-
- Sequence=BAA91750.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for GOLPH3L Gene
Post-translational modifications for GOLPH3L Gene
Other Protein References for GOLPH3L Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for GOLPH3L
- Novus Biologicals Antibodies for GOLPH3L
- Invitrogen Antibodies for GOLPH3L
- antibodies-online Antibodies for GOLPH3L: See all 33
- Search GeneTex for Antibodies for GOLPH3L
Protein Products
-
OriGene Purified Proteins for GOLPH3L
- Search Origene for MassSpec and Protein Over-expression Lysates for GOLPH3L
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- antibodies-online Proteins for GOLPH3L: See all 8
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Assay Products
- antibodies-online Kits for GOLPH3L: See all 1
No data available for DME Specific Peptides for GOLPH3L Gene
Domains & Families for GOLPH3L Gene
Protein Domains for GOLPH3L Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GOLPH3L Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H4A5- Family:
-
- Belongs to the GOLPH3/VPS74 family.
No data available for Gene Families for GOLPH3L Gene
Function for GOLPH3L Gene
Molecular function for GOLPH3L Gene
- UniProtKB/Swiss-Prot Function:
- Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 23275563 |
| GO:0008289 | lipid binding | IEA | -- |
| GO:0070273 | phosphatidylinositol-4-phosphate binding | IEA,IDA | 23345592 |
Phenotypes for GOLPH3L Gene
- GenomeRNAi human phenotypes for GOLPH3L:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for GOLPH3L gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GOLPH3L gene
- Search ViGene Biosciences for GOLPH3L
CRISPR Products
-
OriGene CRISPR knockouts for GOLPH3L
-
Santa Cruz Biotechnology (SCBT) CRISPR for GOLPH3L
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miRNA for GOLPH3L Gene
- miRTarBase miRNAs that target GOLPH3L
-
- hsa-mir-16-5p (MIRT000848)
- hsa-mir-15a-5p (MIRT000849)
- hsa-mir-128-3p (MIRT022020)
- hsa-mir-218-5p (MIRT440539)
- hsa-mir-1273e (MIRT567408)
- hsa-mir-6807-5p (MIRT567409)
- hsa-mir-6077 (MIRT567410)
- hsa-mir-3190-3p (MIRT567411)
- hsa-mir-7-5p (MIRT567412)
- hsa-mir-1233-3p (MIRT567413)
- hsa-mir-1225-3p (MIRT567414)
- hsa-mir-219b-3p (MIRT567415)
- hsa-mir-6840-3p (MIRT567416)
- hsa-mir-302f (MIRT567417)
miRNA Products
- Search ViGene Biosciences for GOLPH3L
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for GOLPH3L
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-
ViGene Biosciences ready-to-package AAV shRNAs for GOLPH3L gene
Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for GOLPH3L
-
ViGene Biosciences adenoviral particle packaged cDNA for GOLPH3L gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLPH3L Gene
Localization for GOLPH3L Gene
Subcellular locations from UniProtKB/Swiss-Prot for GOLPH3L Gene
- Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Note=Phosphatidylinositol 4-phosphate (PtdIns4P)-binding mediates recruitment to Golgi membranes.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| nucleus | 4 |
| cytosol | 4 |
| plasma membrane | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IC | 23345592 |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005802 | trans-Golgi network | IBA | -- |
| GO:0005829 | cytosol | IBA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for GOLPH3L Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transcriptional misregulation in cancer | ||
Pathways by source for GOLPH3L Gene
1 KEGG pathway for GOLPH3L Gene
Interacting Proteins for GOLPH3L Gene
Selected Interacting proteins:
Q9H4A5-GLP3L_HUMAN
ENSP00000271732
for GOLPH3L Gene via
IID
STRING
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | IBA | -- |
| GO:0007030 | Golgi organization | IMP | 23345592 |
| GO:0043001 | Golgi to plasma membrane protein transport | IBA | -- |
| GO:0048194 | Golgi vesicle budding | IBA | -- |
| GO:0050714 | positive regulation of protein secretion | IMP | 23345592 |
No data available for SIGNOR curated interactions for GOLPH3L Gene
Transcripts for GOLPH3L Gene
mRNA/cDNA for GOLPH3L Gene
- (2) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (156) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GOLPH3L Gene
CRISPR Products
-
OriGene CRISPR knockouts for GOLPH3L
-
Santa Cruz Biotechnology (SCBT) CRISPR for GOLPH3L
- GenScript: Design CRISPR guide RNA sequences for GOLPH3L
miRNA Products
- Search ViGene Biosciences for GOLPH3L
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for GOLPH3L
- Browse OriGene Inhibitory RNA Products For GOLPH3L
-
ViGene Biosciences ready-to-package AAV shRNAs for GOLPH3L gene
Clone Products
-
OriGene ORF clones in human for GOLPH3L
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GOLPH3L
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for GOLPH3L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GOLPH3L
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||
| SP7: | - |
Expression for GOLPH3L Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Nasal epithelium (19.2), Skin (9.1), Oral epithelium (7.3), and Salivary gland (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GOLPH3L Gene
NURSA nuclear receptor signaling pathways regulating expression of GOLPH3L Gene:
GOLPH3LSOURCE GeneReport for Unigene cluster for GOLPH3L Gene:
Hs.203699Evidence on tissue expression from TISSUES for GOLPH3L Gene
- Nervous system(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for GOLPH3L
-
OriGene qPCR primer pairs for GOLPH3L
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLPH3L Gene
Orthologs for GOLPH3L Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GOLPH3L 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | GOLPH3L 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | GOLPH3L 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Golph3l 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Golph3l 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GOLPH3L 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GOLPH3L 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GOLPH3L 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | GOLPH3L 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | golph3l 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | golph3l 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | l(2)s5379 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | Y47G6A.18 35 |
|
OneToMany | |
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E02355g 34 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ACL165C 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VPS74 34 35 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC5D6.13 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.486 35 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU06091 34 |
|
- Species where no ortholog for GOLPH3L was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for GOLPH3L Gene
(1) SIMAP similar genes for GOLPH3L Gene using alignment to 3 proteins:
Variants for GOLPH3L Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000028554 | -- | 150,682,095(+) | GTATA(A/C)ATATA | intron-variant | |
| rs1000048454 | -- | 150,689,981(+) | CCCCT(A/C)AGAAG | intron-variant | |
| rs1000151668 | -- | 150,682,528(+) | GGAAG(C/G)TGAGG | intron-variant | |
| rs1000156933 | -- | 150,649,712(+) | ACACA(C/T)AGATC | intron-variant | |
| rs1000206613 | -- | 150,685,978(+) | CAAGC(A/T)ATTCT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2427260 | CNV | deletion | 19546169 |
| nsv1006838 | CNV | gain | 25217958 |
| nsv1014638 | CNV | gain | 25217958 |
| nsv1113176 | CNV | deletion | 24896259 |
| nsv1133906 | CNV | deletion | 24896259 |
| nsv437158 | CNV | loss | 16327808 |
Residual Variation Intolerance Score:
76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.47;
28.65% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for GOLPH3L Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GOLPH3L
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLPH3L Gene
Disorders for GOLPH3L Gene
Relevant External Links for GOLPH3L
No disorders were found for GOLPH3L Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOLPH3L Gene
Publications for GOLPH3L Gene
- GOLPH3L antagonizes GOLPH3 to determine Golgi morphology. (PMID: 23345592) Ng M.M. … Field S.J. (Mol. Biol. Cell 2013) 3 4 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Proteomics characterization of abundant Golgi membrane proteins. (PMID: 11042173) Bell A.W. … Bergeron J.J.M. (J. Biol. Chem. 2001) 3 4 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
Products for GOLPH3L Gene
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- Custom Antibody ServicesOriGene Antibodies for GOLPH3L
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- antibodies-online Antibodies for GOLPH3L: See all 33
- antibodies-online Kits for GOLPH3L: See all 1
- antibodies-online Proteins for GOLPH3L: See all 8
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- ViGene Biosciences adenoviral particle packaged cDNA for GOLPH3L gene
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- Horizon Cell Lines for GOLPH3L
- Cyagen custom Knockout/knockin (KOKI) mouse models for GOLPH3L
- VectorBuilder custom plasmid, inducible vectors for GOLPH3L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GOLPH3L
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for GOLPH3L Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
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