Aliases for GOLPH3L Gene
Aliases for GOLPH3L Gene
External Ids for GOLPH3L Gene
- HGNC: 24882
- Entrez Gene: 55204
- Ensembl: ENSG00000143457
- OMIM: 612208
- UniProtKB: Q9H4A5
Previous GeneCards Identifiers for GOLPH3L Gene
- GC01M147432
- GC01M148885
- GC01M150618
- GC01M121996
Summaries for GOLPH3L Gene
-
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is localized at the Golgi stack and may have a regulatory role in Golgi trafficking. [provided by RefSeq, Jul 2008]
GeneCards Summary for GOLPH3L Gene
GOLPH3L (Golgi Phosphoprotein 3 Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol-4-phosphate binding. An important paralog of this gene is GOLPH3.
UniProtKB/Swiss-Prot for GOLPH3L Gene
-
Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane.
Additional gene information for GOLPH3L Gene
- Monarch Initiative
- Search for GOLPH3L at DataMed
- Search for GOLPH3L at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLPH3L Gene
Genomics for GOLPH3L Gene
GeneHancer (GH) Regulatory Elements for GOLPH3L Gene
Promoters and enhancers for GOLPH3L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around GOLPH3L on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GOLPH3L gene promoter:
Regulatory Element Products
Genomic Locations for GOLPH3L Gene
Genomic Locations for GOLPH3L Gene
- chr1:150,646,225-150,697,956
- (GRCh38/hg38)
- Size:
- 51,732 bases
- Orientation:
- Minus strand
- chr1:150,618,701-150,669,672
- (GRCh37/hg19)
Genomic View for GOLPH3L Gene
Genes around GOLPH3L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.3 by Ensembl
- 1q21.3 by Entrez Gene
- 1q21.3 by HGNC
GOLPH3L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GOLPH3L Gene
Proteins for GOLPH3L Gene
-
Protein details for GOLPH3L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H4A5-GLP3L_HUMAN
- Recommended name:
- Golgi phosphoprotein 3-like
- Protein Accession:
- Q9H4A5
- B1AN09
- B7Z6N3
- Q9NVK0
Protein attributes for GOLPH3L Gene
- Size:
- 285 amino acids
- Molecular mass:
- 32767 Da
- Quaternary structure:
-
- Homooligomer (By similarity). Does not interact MYO18; differs from GOLPH3 by its inability to interact with MYO18. May interact with ARF1.
- SequenceCaution:
-
- Sequence=BAA91750.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for GOLPH3L Gene
Post-translational modifications for GOLPH3L Gene
No Post-translational modifications
Other Protein References for GOLPH3L Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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Protein Products
-
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Assay Products
- antibodies-online: Search results for 1 available GOLPH3L Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for GOLPH3L Gene
Domains & Families for GOLPH3L Gene
Gene Families for GOLPH3L Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for GOLPH3L Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GOLPH3L Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H4A5- Family:
-
- Belongs to the GOLPH3/VPS74 family.
Function for GOLPH3L Gene
Molecular function for GOLPH3L Gene
- UniProtKB/Swiss-Prot Function:
- Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane.
Phenotypes From GWAS Catalog for GOLPH3L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 23275563 |
| GO:0008289 | lipid binding | IEA | -- |
| GO:0070273 | phosphatidylinositol-4-phosphate binding | IEA,IDA | 23345592 |
Phenotypes for GOLPH3L Gene
- GenomeRNAi human phenotypes for GOLPH3L:
Animal Model Products
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-
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Vectors and viruses for KO, Activation, Repression, and more
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miRNA for GOLPH3L Gene
- miRTarBase miRNAs that target GOLPH3L
-
- hsa-mir-16-5p (MIRT000848)
- hsa-mir-15a-5p (MIRT000849)
- hsa-mir-128-3p (MIRT022020)
- hsa-mir-218-5p (MIRT440539)
- hsa-mir-1273e (MIRT567408)
- hsa-mir-6807-5p (MIRT567409)
- hsa-mir-6077 (MIRT567410)
- hsa-mir-3190-3p (MIRT567411)
- hsa-mir-7-5p (MIRT567412)
- hsa-mir-1233-3p (MIRT567413)
- hsa-mir-1225-3p (MIRT567414)
- hsa-mir-219b-3p (MIRT567415)
- hsa-mir-6840-3p (MIRT567416)
- hsa-mir-302f (MIRT567417)
- hsa-mir-10b-3p (MIRT735854)
- hsa-mir-491-3p (MIRT749190)
- hsa-mir-493-3p (MIRT749249)
- hsa-mir-6715b-3p (MIRT753682)
miRNA Products
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Inhibitory RNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLPH3L Gene
Localization for GOLPH3L Gene
Subcellular locations from UniProtKB/Swiss-Prot for GOLPH3L Gene
- Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Note=Phosphatidylinositol 4-phosphate (PtdIns4P)-binding mediates recruitment to Golgi membranes.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| nucleus | 4 |
| cytosol | 4 |
| plasma membrane | 2 |
- Cytosol (2)
- Nucleoplasm (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IC | 23345592 |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005802 | trans-Golgi network | IBA | -- |
| GO:0005829 | cytosol | IBA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for GOLPH3L Gene
No Data Available
Interacting Proteins for GOLPH3L Gene
Selected Interacting proteins:
Q9H4A5-GLP3L_HUMAN
ENSP00000271732
for GOLPH3L Gene via
IID
STRING
MINT
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | IBA | -- |
| GO:0007030 | Golgi organization | IMP | 23345592 |
| GO:0043001 | Golgi to plasma membrane protein transport | IBA | -- |
| GO:0048194 | Golgi vesicle budding | IBA | -- |
| GO:0050714 | positive regulation of protein secretion | IMP | 23345592 |
No data available for Pathways by source and SIGNOR curated interactions for GOLPH3L Gene
Transcripts for GOLPH3L Gene
mRNA/cDNA for GOLPH3L Gene
- (2) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (156) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GOLPH3L Gene
CRISPR Products
-
OriGene CRISPR knockouts for GOLPH3L
- genomics-online: gRNA clones - Search results for 147 available GOLPH3L gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GOLPH3L
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miRNA Products
- Search ViGene Biosciences for GOLPH3L
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for GOLPH3L
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- genomics-online: shRNA clones - Search results for 147 available GOLPH3L gene related products
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-
ViGene Biosciences ready-to-package AAV shRNAs for GOLPH3L gene
Clone Products
- Sino Biological Human cDNA Clone for GOLPH3L
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for GOLPH3L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GOLPH3L
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for GOLPH3L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||
| SP7: | - |
Expression for GOLPH3L Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Nasal epithelium (19.2), Skin (9.1), Oral epithelium (7.3), and Salivary gland (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GOLPH3L Gene
NURSA nuclear receptor signaling pathways regulating expression of GOLPH3L Gene:
GOLPH3LSOURCE GeneReport for Unigene cluster for GOLPH3L Gene:
Hs.203699Evidence on tissue expression from TISSUES for GOLPH3L Gene
- Nervous system(2.1)
Primer Products
-
OriGene qPCR primer pairs for GOLPH3L
-
OriGene qPCR primer pairs and template standards for GOLPH3L
- genomics-online: primer clones - Search results for 147 available GOLPH3L gene related products
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No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLPH3L Gene
Orthologs for GOLPH3L Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GOLPH3L 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GOLPH3L 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GOLPH3L 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Golph3l 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Golph3l 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GOLPH3L 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GOLPH3L 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GOLPH3L 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GOLPH3L 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | golph3l 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | golph3l 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | l(2)s5379 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | Y47G6A.18 34 |
|
OneToMany | |
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E02355g 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ACL165C 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VPS74 33 34 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC5D6.13 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.486 34 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU06091 33 |
|
- Species where no ortholog for GOLPH3L was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for GOLPH3L Gene
(1) SIMAP similar genes for GOLPH3L Gene using alignment to 3 proteins:
Variants for GOLPH3L Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000028554 | -- | 150,682,095(-) | C/A | intron_variant | |
| rs1000048454 | -- | 150,689,981(-) | C/A | intron_variant | |
| rs1000151668 | -- | 150,682,528(-) | C/G | intron_variant | |
| rs1000156933 | -- | 150,649,712(-) | T/C | intron_variant | |
| rs1000206613 | -- | 150,685,978(-) | A/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2427260 | CNV | deletion | 19546169 |
| nsv1006838 | CNV | gain | 25217958 |
| nsv1014638 | CNV | gain | 25217958 |
| nsv1113176 | CNV | deletion | 24896259 |
| nsv1133906 | CNV | deletion | 24896259 |
| nsv437158 | CNV | loss | 16327808 |
Residual Variation Intolerance Score:
76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.47;
28.65% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GOLPH3L Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GOLPH3L
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLPH3L Gene
Disorders for GOLPH3L Gene
Additional Disease Information for GOLPH3L
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for GOLPH3L Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOLPH3L Gene
Publications for GOLPH3L Gene
- GOLPH3L antagonizes GOLPH3 to determine Golgi morphology. (PMID: 23345592) Ng MM … Field SJ (Molecular biology of the cell 2013) 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Proteomics characterization of abundant Golgi membrane proteins. (PMID: 11042173) Bell AW … Bergeron JJ (The Journal of biological chemistry 2001) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for GOLPH3L Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 38 available GOLPH3L Antibodies ranked by validation data
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Sources for GOLPH3L Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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