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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GOLPH3L Gene

protein-coding GIFtS: 51
GCID: GC01M150618

Golgi Phosphoprotein 3-Like

Search for GOLPH3L
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Golgi Phosphoprotein 3-Like¹ ²
GPP34R² ³ ⁵
GPP34-Related Protein² ³

External Ids:	HGNC: 24882¹	Entrez Gene: 55204²	Ensembl: ENSG00000143457⁷	OMIM: 612208⁵	UniProtKB: Q9H4A5³

Export aliases for GOLPH3L gene to outside databases

Previous GC identifers: GC01M147432 GC01M148885 GC01M121996

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GOLPH3L Gene:

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum.

The protein encoded by this gene is localized at the Golgi stack and may have a regulatory role in Golgi trafficking.

(provided by RefSeq, Jul 2008)

GeneCards Summary for GOLPH3L Gene:

GOLPH3L (golgi phosphoprotein 3-like) is a protein-coding gene. GO annotations related to this gene include lipid binding. An important paralog of this gene is GOLPH3.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NT_004487.19 NC_018912.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GOLPH3L gene promoter:
SRF HFH-3 RP58 SRF (504 AA) GATA-1 FOXI1 POU2F1 POU2F1a FOXJ2 (long isoform) FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GOLPH3L promoter sequence

Search SABiosciences Chromatin IP Primers for GOLPH3L

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GOLPH3L

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21

GOLPH3L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GOLPH3L gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M150618: view genomic region (about GC identifiers)

Start:	150,618,701 bp from pter	End:	150,669,672 bp from pter
Size:	50,972 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GLP3L_HUMAN, Q9H4A5 (See protein sequence)

Recommended Name: Golgi phosphoprotein 3-like

Size: 285 amino acids; 32767 Da

Subunit: Homotetramer (By similarity)

Subcellular location: Cytoplasm (By similarity). Golgi apparatus, Golgi stack membrane; Peripheral membrane protein;

Cytoplasmic side (By similarity). Note=Phosphatidylinositol 4-phosphate (PtdIns4P) binding is essential for Golgi

localization (By similarity)

Sequence caution: Sequence=BAA91750.1; Type=Erroneous initiation;

Secondary accessions: B1AN09 Q9NVK0

Explore the universe of human proteins at neXtProt for GOLPH3L: NX_Q9H4A5

Explore proteomics data for GOLPH3L at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9H4A5

GOLPH3L Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_060648.2

ENSEMBL proteins:

ENSP00000271732 ENSP00000410476 ENSP00000446070

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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IC	--
GO:0032580	Golgi cisterna membrane	IEA	--
GO:0032588	trans-Golgi network membrane	IC	--

GOLPH3L for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro protein domain:

IPR008628 GPP34

Graphical View of Domain Structure for InterPro Entry Q9H4A5

ProtoNet protein and cluster: Q9H4A5

1 Blocks protein domain: IPB008628 Golgi phosphoprotein 3

UniProtKB/Swiss-Prot: GLP3L_HUMAN, Q9H4A5

Similarity: Belongs to the GOLPH3/VPS74 family

GOLPH3L for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0008289	lipid binding	--	--
GO:0070273	phosphatidylinositol-4-phosphate binding	IDA	--

GOLPH3L for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for GOLPH3L:

Large cells

Animal Models:

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		SwitchGear 3'UTR luciferase reporter plasmid: GOLPH3L 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOLPH3L

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for GOLPH3L About

See pathways by source

SuperPath

Contained pathways About

Transcriptional misregulation in cancer

Transcriptional misregulation in cancer

Pathways by source See SuperPaths
Show all pathways

1 Kegg Pathway (Kegg details for GOLPH3L):

Transcriptional misregulation in cancer

GOLPH3L for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GOLPH3L

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/50 Interacting proteins for GOLPH3L (Q9H4A5^{1, 3} ENSP00000271732⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 50)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARCN1	P48444³, ENSP00000264028⁴	I2D: score=1 STRING: ENSP00000264028
COPA	P53621³, ENSP00000357048⁴	I2D: score=1 STRING: ENSP00000357048
COPB1	P53618³, ENSP00000249923⁴	I2D: score=1 STRING: ENSP00000249923
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
VPS26B	Q4G0F5³	I2D: score=5

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007030	Golgi organization	IMP	--
GO:0050714	positive regulation of protein secretion	IMP	--

GOLPH3L for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GOLPH3L (GLP3L)

Search CenterWatch for drugs/clinical trials and news about GOLPH3L / GLP3L

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GOLPH3L gene:

NM_018178.5

Unigene Cluster for GOLPH3L:

Golgi phosphoprotein 3-like

Hs.203699 [show with all ESTs]

Unigene Representative Sequence: NM_018178

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000271732(uc001evj.2 uc010pci.1) ENST00000427665 ENST00000479757

ENST00000540514

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		hsa-miR-3074-3p hsa-miR-449a hsa-miR-3921 hsa-miR-29b-1* hsa-miR-570 hsa-miR-29a* hsa-miR-23a hsa-miR-761

		SwitchGear 3'UTR luciferase reporter plasmid: GOLPH3L 3' UTR sequence

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Additional mRNA sequence:

AJ296153.1 AK001549.1 AK300635.1 AK315594.1 BC013870.2

9 DOTS entries:

DT.91785466 DT.100760947 DT.100685558 DT.100694501 DT.121367804 DT.121367815 DT.121368030 DT.121368034

DT.95359583

24/156 AceView cDNA sequences (see all 156):

BF591231 BM928226 BM451954 BM750834 AA232616 AL703369 BG742527 NM_018178

BM717550 BQ018943 CR622887 BF001715 AI623448 CB243830 CB149454 BM674827

BM273025 BQ184958 BM969175 BQ267824 AW445094 AU130135 AA147436 BP341735

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GOLPH3L (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	·	7d
SP1:											-				-		-
SP2:											-				-		-
SP3:											-				-
SP4:															-		-
SP5:											-				-		-						-

ECgene alternative splicing isoforms for GOLPH3L

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GOLPH3L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AATTGAAACC

About this image

See GOLPH3L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GOLPH3L

SOURCE GeneReport for Unigene cluster: Hs.203699

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for GOLPH3L gene from 6/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Golph3l^{1 , 5}	golgi phosphoprotein 3-like^{1, 5}	89.59(n)¹ 95.09(a)¹		3 (40.74 cM)⁵ 229593¹ NM_146133.3¹ NP_666245.2¹ 95588934⁵
chicken (Gallus gallus)	Aves	GOLPH3L¹	golgi phosphoprotein 3-like	68.22(n) 72.4(a)		425072 XM_422865.3 XP_422865.3
lizard (Anolis carolinensis)	Reptilia	GOLPH3L⁶	Uncharacterized protein	84(a)	1 ↔ 1	GL343862.1(74320-91999)
tropical clawed frog (Xenopus tropicalis)	Amphibia	CF220195.1²	--	76.53(n)		CF220195.1
zebrafish (Danio rerio)	Actinopterygii	golph3l¹	golgi phosphoprotein 3-like	63.5(n) 63.73(a)		569617 NM_001037699.1 NP_001032788.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	VPS74⁶	Protein required for Golgi localization of glycosy...	33(a)	1 → many	IV(1221112-1222149)

ENSEMBL Gene Tree for GOLPH3L (if available)
TreeFam Gene Tree for GOLPH3L (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GOLPH3L gene

GOLPH3²

1 SIMAP similar gene for GOLPH3L using alignment to 3 protein entries: GLP3L_HUMAN F5H4M3_HUMAN Q5T5I6_HUMAN(see first protein):

GOLPH3

GOLPH3L for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs71086589^1,2	C	--	150625932(+)	`TTTTT-/TGGAGA`	1	--	int¹		1		NA	2
rs12058548^1,2	A	--	150666273(+)	`TATGTA/GTGTGT`	1	--	int¹		0	--	--	--	--
rs11204703^1,2	C,A	--	150666297(+)	`TGTGTG/ATATAT`	1	--	int¹		3		NA	6
rs190625757^1,2		--	150666299(+)	`TGTATA/GTATAT`	1	--	int¹		0	--	--	--	--
rs11799714^1,2	H	--	150666311(+)	`tatatA/Gtatat`	1	--	int¹		0	--	--	--	--
rs12731712^1,2		--	150666316(+)	`atataC/Tatata`	1	--	int¹		0	--	--	--	--
rs66627372^1,2	C	--	150666324(+)	`TATAT-/TT/TT T/TTTTTTTTTT`	2	--	int¹ cds¹		2		NA	4
rs7556489^1,2	C	--	150666325(+)	`tatatA/Tttttt`	1	--	int¹ trp³		1		NA	2
rs11799727^1,2	C,F,H	--	150666379(+)	`catccG/Aggctg`	1	--	int¹		1		NA	2
rs140984002^1,2		--	157119935(+)	`AATTGA/GCTAAT`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GOLPH3L (150618701 - 150669672 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for GOLPH3L: About this table

Variant ID	Type	Subtype	PubMed ID
esv2427260	CNV	Deletion	19546169
nsv437158	CNV	Loss	16327808
nsv872417	CNV	Loss	21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GOLPH3L for disorders About MalaCards

GOLPH3L for disorders About GeneDecksing

OMIM gene information: 612208 OMIM disorders: --

Genetic Association Database (GAD): GOLPH3L
Human Genome Epidemiology (HuGE) Navigator: GOLPH3L (1 document)

Export disorders for GOLPH3L gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for GOLPH3L gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with GOLPH3L)

Utopia: connect your pdf to the dynamic
world of online information

Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Proteomics characterization of abundant Golgi membrane proteins. (PubMed id 11042173)^{1, 2} Bell A.W....Bergeron J.J.M. (2001)
VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)¹ Yu C.C....Chow L.P. (2013)
Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)¹ Suter B....Wanker E.E. (2013)
Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment. (PubMed id 23585552)¹ Kirin M....Mitry D. (2013)
GOLPH3L antagonizes GOLPH3 to determine Golgi morpholo gy. (PubMed id 23345592)¹ Ng M.M....Field S.J. (2013)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55204	HGNC: 24882	AceView: GPP34R	Ensembl:ENSG00000143457	euGenes: HUgn55204
ECgene: GOLPH3L	Kegg: 55204	H-InvDB: GOLPH3L

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GOLPH3L	Pharmacogenomics, SNPs, Pathways

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Golgi Phosphoprotein 3-Like

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Golgi Phosphoprotein 3-Like

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