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Aliases for GOLPH3L Gene

Aliases for GOLPH3L Gene

  • Golgi Phosphoprotein 3 Like 2 3 5
  • Golgi Phosphoprotein 3-Like 2 3
  • GPP34-Related Protein 3 4
  • GPP34R 3 4

External Ids for GOLPH3L Gene

Previous GeneCards Identifiers for GOLPH3L Gene

  • GC01M147432
  • GC01M148885
  • GC01M150618
  • GC01M121996

Summaries for GOLPH3L Gene

Entrez Gene Summary for GOLPH3L Gene

  • The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is localized at the Golgi stack and may have a regulatory role in Golgi trafficking. [provided by RefSeq, Jul 2008]

GeneCards Summary for GOLPH3L Gene

GOLPH3L (Golgi Phosphoprotein 3 Like) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include phosphatidylinositol-4-phosphate binding. An important paralog of this gene is GOLPH3.

UniProtKB/Swiss-Prot for GOLPH3L Gene

  • Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLPH3L Gene

Genomics for GOLPH3L Gene

Regulatory Elements for GOLPH3L Gene

Enhancers for GOLPH3L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G150557 1.7 Ensembl ENCODE dbSUPER 36.6 +128.7 128652 23.1 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 HORMAD1 GOLPH3L SF3B4 SETDB1 CTSK VPS45 PRPF3 ENSA ARNT CTSS
GH01G151004 1.5 ENCODE dbSUPER 34 -309.5 -309489 5.2 CREB3L1 MLX ZFP64 YBX1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 PRPF3 SETDB1 UBE2D3P3 MRPL9 GOLPH3L GABPB2 LYSMD1 CTSK HORMAD1 RN7SL444P
GH01G151308 2 FANTOM5 Ensembl ENCODE dbSUPER 23 -614.0 -613981 6.1 CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MRPL9 GABPB2 SETDB1 GOLPH3L LYSMD1 PRPF3 UBE2D3P3 ZNF687 ADAMTSL4 RFX5
GH01G150626 1.7 FANTOM5 ENCODE dbSUPER 25.3 +68.6 68585 4.9 HDGF PKNOX1 FOXA2 ARNT WRNIP1 SIN3A ARID4B DMAP1 YBX1 ZNF2 HORMAD1 SETDB1 GOLPH3L UBE2D3P3 PRPF3 MCL1 SF3B4 ADAMTSL4 RPS10P6 GABPB2
GH01G150486 1.2 ENCODE 34.7 +210.3 210317 1.7 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 SETDB1 PRPF3 SF3B4 GOLPH3L UBE2D3P3 ADAMTSL4 GABPB2 MRPS21 APH1A HIST2H2BD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GOLPH3L on UCSC Golden Path with GeneCards custom track

Promoters for GOLPH3L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000013536 856 1800 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 ZNF143

Genomic Location for GOLPH3L Gene

Chromosome:
1
Start:
150,646,225 bp from pter
End:
150,697,956 bp from pter
Size:
51,732 bases
Orientation:
Minus strand

Genomic View for GOLPH3L Gene

Genes around GOLPH3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLPH3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLPH3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLPH3L Gene

Proteins for GOLPH3L Gene

  • Protein details for GOLPH3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4A5-GLP3L_HUMAN
    Recommended name:
    Golgi phosphoprotein 3-like
    Protein Accession:
    Q9H4A5
    Secondary Accessions:
    • B1AN09
    • B7Z6N3
    • Q9NVK0

    Protein attributes for GOLPH3L Gene

    Size:
    285 amino acids
    Molecular mass:
    32767 Da
    Quaternary structure:
    • Homooligomer (By similarity). Does not interact MYO18; differs from GOLPH3 by its inability to interact with MYO18. May interact with ARF1.
    SequenceCaution:
    • Sequence=BAA91750.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for GOLPH3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOLPH3L Gene

Post-translational modifications for GOLPH3L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GOLPH3L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GOLPH3L Gene

Domains & Families for GOLPH3L Gene

Protein Domains for GOLPH3L Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GOLPH3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H4A5

UniProtKB/Swiss-Prot:

GLP3L_HUMAN :
  • Belongs to the GOLPH3/VPS74 family.
Family:
  • Belongs to the GOLPH3/VPS74 family.
genes like me logo Genes that share domains with GOLPH3L: view

No data available for Gene Families for GOLPH3L Gene

Function for GOLPH3L Gene

Molecular function for GOLPH3L Gene

UniProtKB/Swiss-Prot Function:
Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane.

Gene Ontology (GO) - Molecular Function for GOLPH3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23275563
GO:0008289 lipid binding IEA --
GO:0070273 phosphatidylinositol-4-phosphate binding IEA,IDA 23345592
genes like me logo Genes that share ontologies with GOLPH3L: view
genes like me logo Genes that share phenotypes with GOLPH3L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLPH3L Gene

Localization for GOLPH3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLPH3L Gene

Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Note=Phosphatidylinositol 4-phosphate (PtdIns4P)-binding mediates recruitment to Golgi membranes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLPH3L gene
Compartment Confidence
golgi apparatus 5
nucleus 4
cytosol 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for GOLPH3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IC 23345592
GO:0005794 Golgi apparatus IEA --
GO:0005802 trans-Golgi network IBA --
GO:0005829 cytosol IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GOLPH3L: view

Pathways & Interactions for GOLPH3L Gene

genes like me logo Genes that share pathways with GOLPH3L: view

Pathways by source for GOLPH3L Gene

1 KEGG pathway for GOLPH3L Gene

Gene Ontology (GO) - Biological Process for GOLPH3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IBA --
GO:0007030 Golgi organization IMP 23345592
GO:0043001 Golgi to plasma membrane protein transport IBA --
GO:0048194 Golgi vesicle budding IBA --
GO:0050714 positive regulation of protein secretion IMP 23345592
genes like me logo Genes that share ontologies with GOLPH3L: view

No data available for SIGNOR curated interactions for GOLPH3L Gene

Drugs & Compounds for GOLPH3L Gene

No Compound Related Data Available

Transcripts for GOLPH3L Gene

Unigene Clusters for GOLPH3L Gene

Golgi phosphoprotein 3-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOLPH3L Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - - -
SP6: - - - - -
SP7: -

Relevant External Links for GOLPH3L Gene

GeneLoc Exon Structure for
GOLPH3L
ECgene alternative splicing isoforms for
GOLPH3L

Expression for GOLPH3L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GOLPH3L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GOLPH3L Gene

This gene is overexpressed in Nasal epithelium (19.2), Skin (9.1), Oral epithelium (7.3), and Salivary gland (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GOLPH3L Gene



Protein tissue co-expression partners for GOLPH3L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GOLPH3L Gene:

GOLPH3L

SOURCE GeneReport for Unigene cluster for GOLPH3L Gene:

Hs.203699

Evidence on tissue expression from TISSUES for GOLPH3L Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with GOLPH3L: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLPH3L Gene

Orthologs for GOLPH3L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GOLPH3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOLPH3L 34 35
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia GOLPH3L 34 35
  • 93.33 (n)
cow
(Bos Taurus)
Mammalia GOLPH3L 34 35
  • 92.63 (n)
rat
(Rattus norvegicus)
Mammalia Golph3l 34
  • 89.94 (n)
mouse
(Mus musculus)
Mammalia Golph3l 34 16 35
  • 89.59 (n)
oppossum
(Monodelphis domestica)
Mammalia GOLPH3L 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GOLPH3L 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves GOLPH3L 34 35
  • 68.22 (n)
lizard
(Anolis carolinensis)
Reptilia GOLPH3L 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia golph3l 34
  • 73.21 (n)
zebrafish
(Danio rerio)
Actinopterygii golph3l 34 35
  • 63.5 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(2)s5379 35
  • 59 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y47G6A.18 35
  • 54 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E02355g 34
  • 53.99 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL165C 34
  • 53.86 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS74 34 35
  • 53.62 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC5D6.13 34
  • 53.86 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.486 35
  • 53 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU06091 34
  • 52.17 (n)
Species where no ortholog for GOLPH3L was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GOLPH3L Gene

ENSEMBL:
Gene Tree for GOLPH3L (if available)
TreeFam:
Gene Tree for GOLPH3L (if available)

Paralogs for GOLPH3L Gene

Paralogs for GOLPH3L Gene

(1) SIMAP similar genes for GOLPH3L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GOLPH3L: view

Variants for GOLPH3L Gene

Sequence variations from dbSNP and Humsavar for GOLPH3L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000028554 -- 150,682,095(+) GTATA(A/C)ATATA intron-variant
rs1000048454 -- 150,689,981(+) CCCCT(A/C)AGAAG intron-variant
rs1000151668 -- 150,682,528(+) GGAAG(C/G)TGAGG intron-variant
rs1000156933 -- 150,649,712(+) ACACA(C/T)AGATC intron-variant
rs1000206613 -- 150,685,978(+) CAAGC(A/T)ATTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GOLPH3L Gene

Variant ID Type Subtype PubMed ID
esv2427260 CNV deletion 19546169
nsv1006838 CNV gain 25217958
nsv1014638 CNV gain 25217958
nsv1113176 CNV deletion 24896259
nsv1133906 CNV deletion 24896259
nsv437158 CNV loss 16327808

Variation tolerance for GOLPH3L Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GOLPH3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLPH3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLPH3L Gene

Disorders for GOLPH3L Gene

Relevant External Links for GOLPH3L

Genetic Association Database (GAD)
GOLPH3L
Human Genome Epidemiology (HuGE) Navigator
GOLPH3L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GOLPH3L

No disorders were found for GOLPH3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOLPH3L Gene

Publications for GOLPH3L Gene

  1. GOLPH3L antagonizes GOLPH3 to determine Golgi morphology. (PMID: 23345592) Ng M.M. … Field S.J. (Mol. Biol. Cell 2013) 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Proteomics characterization of abundant Golgi membrane proteins. (PMID: 11042173) Bell A.W. … Bergeron J.J.M. (J. Biol. Chem. 2001) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for GOLPH3L Gene

Sources for GOLPH3L Gene

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