GOLPH3L Gene
protein-coding GIFtS: 48
GCID: GC01M150618
|
|
golgi phosphoprotein 3-like
| |
Aliases
for GOLPH3L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Golgi Phosphoprotein 3-Like1 2 | | GPP34R1 2 3 5 | | GPP34-Related Protein2 3 |
Export aliases for GOLPH3L gene to outside databasesPrevious GC identifers: GC01M147432 GC01M148885 GC01M121996 |
Summaries
for GOLPH3L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GOLPH3L:
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum.The protein encoded by this gene is localized at the Golgi stack and may have a regulatory role in Golgi trafficking.(provided by RefSeq, Jul 2008)
|
Genomic Views
for GOLPH3L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GOLPH3L gene promoter:
SRF HFH-3 RP58 SRF (504 AA) GATA-1 FOXI1 POU2F1 POU2F1a FOXJ2 (long isoform) FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for GOLPH3L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GOLPH3L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21GOLPH3L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M150618: view genomic region
(about GC identifiers)
Start:
|
150,618,701 bp from pter |
End:
|
150,669,672 bp from pter |
Size:
|
50,972 bases |
Orientation:
|
minus strand |
|
Proteins
for GOLPH3L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GLP3L_HUMAN, Q9H4A5 (See
protein sequence)Recommended Name: Golgi phosphoprotein 3-like Size: 285 amino acids; 32767 Da
Subunit: Homotetramer (By similarity)
Subcellular location: Cytoplasm (By similarity). Golgi apparatus, Golgi stack membrane; Peripheral membrane protein;Cytoplasmic side (By similarity). Note=Phosphatidylinositol 4-phosphate (PtdIns4P) binding is essential for Golgilocalization (By similarity)
Sequence caution: Sequence=BAA91750.1; Type=Erroneous initiation;
Secondary accessions: B1AN09 Q9NVK0Explore the universe of human proteins at neXtProt for GOLPH3L: NX_Q9H4A5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H4A5
GOLPH3L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060648.2
ENSEMBL proteins: ENSP00000271732 ENSP00000410476 ENSP00000446070
Human Recombinant Protein Products for GOLPH3L:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0032580 | Golgi cisterna membrane |
IEA | -- |
GOLPH3L for ontologies About GeneDecksing
GOLPH3L Antibody Products:
Assay Products for GOLPH3L: |
Protein
Domains /
Families
for GOLPH3L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GOLPH3L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H4A5ProtoNet protein and cluster: Q9H4A5 1 Blocks protein family: IPB008628 Golgi phosphoprotein 3
UniProtKB/Swiss-Prot: GLP3L_HUMAN, Q9H4A5Similarity: Belongs to the GOLPH3/VPS74 family |
Function
for GOLPH3L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008289 | lipid binding |
IEA | -- |
GOLPH3L for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for GOLPH3L:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GOLPH3L (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GOLPH3L
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOLPH3L |
|
Pathways & Interactions
for GOLPH3L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GOLPH3L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/50 Interacting proteins for GOLPH3L (Q9H4A51, 3 ENSP000002717324) via UniProtKB, MINT, STRING, and/or I2D (see all 50)About this table
|
Drugs & Compounds
for GOLPH3L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GOLPH3L
Search CenterWatch for drugs/clinical trials and news about GOLPH3L / GLP3L
|
Transcripts
for GOLPH3L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GOLPH3L gene: NM_018178.5 Unigene Cluster for GOLPH3L: Golgi phosphoprotein 3-like Hs.740573 [show with all ESTs]Unigene Representative Sequence: NM_0181784 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000271732(uc001evj.2 uc010pci.1) ENST00000427665 ENST00000479757
ENST00000540514
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GOLPH3L (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GOLPH3L
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Additional cDNA sequence: AJ296153.1 AK001549.1 AK300635.1 AK315594.1 BC013870.2 9 DOTS entries: DT.91785466 DT.100760947 DT.100685558 DT.100694501 DT.121367804 DT.121367815 DT.121368030 DT.121368034 DT.95359583 156 AceView cDNA sequences (see top 24): BM719082 BP341735 CR622887 AA232616 BF591231 CB243830 BM928226 BM273025 AL703369 AA147436 AU130135 BF001715 BM674827 CB149454 AI623448 AI017699 BQ018943 NM_018178 BQ267824 BM750834 BM717550 BQ184958 BM969175 BG742527 AW445094 AI762255 BM451954 BU176201 BG742529 BI712203 AL526724 BP374278 AU151979 N64405 BQ027198 BX390638 AA232516 BG492388 BQ130668 AA364220 CB240985 BF224442 AW068042 AI367102 CD357986 CA419828 AJ296153 CB241934 CB242081 BU686445 AA306477 AI758471 BG166353 BI858234 AA806432 BC013870 AI804436 AA766615 BM273261 BX400218 AI765442 AW009216 AI091050 AK001549 CD704942 AU119018 BM683052 BE245166 BM510049 BX405157 CA944503 BQ775969 BI858315 AL702993 AI492096 BI713152 AW612527 BX091283 AA255863 AI094117 AL526691 BQ440124 BM681967 AL703592 AI275953 BF514967 BG111844 CB123964 AA774220 AI762634 BM503905 AU128539 AI925843 AI909300 R73907 BX426342 BE744327 AI440402 BM729024 AW953800 AI027112 AL515751 AA196765 BI762536 AI351562 AI630279 AA180380 BF701347 AI400146 AI364563 BE889331 BQ130935 BG501672 BI495967 BG899952 BF184156 BM983841 AI867979 BF061086 BU570796 BE734748 BG777823 BI495966 AA837776 CB957176 AL519593 AI818047 BF115327 BG741579 AA364558 BU675423 CD704132 AI200898 R74000 BQ268076 BQ186288 AU153520 AU145454 BG120722 AI627231 BG431199 AU152152 AU150811 CA314815 CD356069 BF925868 AI949502 CD704210 BM988199 BF978867 BI550986 AW205408 AL519594 BG284301 BQ181024 CD694229
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GOLPH3L (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|
|
| SP1: | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | - | | - | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for GOLPH3L
|
Expression
for GOLPH3L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GOLPH3L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATTGAAACC
About this image
See GOLPH3L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GOLPH3L
SOURCE GeneReport for Unigene cluster: Hs.740573
SABiosciences Custom PCR Arrays for GOLPH3L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GOLPH3L
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOLPH3L |
Orthologs
for GOLPH3L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for GOLPH3L gene from 6/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
GOLPH3L1 |
golgi phosphoprotein 3-like |
68.22(n)
72.4(a) |
|
425072 XM_422865.3 XP_422865.3 |
lizard
(Anolis carolinensis) |
Reptilia |
GOLPH3L6 |
-- |
84(a) |
1 ↔ 1 |
GL343862.1(79080-91999) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
CF220195.12 |
-- |
76.53(n) |
|
CF220195.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
golph3l1 |
golgi phosphoprotein 3-like |
63.5(n)
63.73(a) |
|
569617 NM_001037699.1 NP_001032788.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
l(2)s53796 |
lethal (2) s5379 |
62(a) |
1 → many |
2L(2226523-2231099) |
worm
(Caenorhabditis elegans) |
Secernentea |
Y47G6A.186 |
Protein Y47G6A.18 |
55(a) |
1 → many |
I(3508638-3512738) |
ENSEMBL Gene Tree for GOLPH3L (if available)
TreeFam Gene Tree for GOLPH3L (if available) |
Paralogs
for GOLPH3L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GOLPH3L gene
- GOLPH32
1 SIMAP similar gene for GOLPH3L using alignment to 3 protein entries: GLP3L_HUMAN (see all proteins):GOLPH3
GOLPH3L for paralogs About GeneDecksing
|
Genomic Variants
for GOLPH3L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GOLPH3L (150618701 - 150669672 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GOLPH3L
1 CNV: 97507 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GOLPH3L |
|
Disorders
/ Diseases
for GOLPH3L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 GOLPH3L for disorders About MalaCards
GOLPH3L for disorders About GeneDecksing
OMIM gene information: 612208
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: GOLPH3L (1 document)
Export disorders for GOLPH3L gene to outside databases
|
Publications
for GOLPH3L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GOLPH3L gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with GOLPH3L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Proteomics characterization of abundant Golgi membrane proteins. (PubMed id 11042173)1, 2 Bell A.W....Bergeron J.J.M. (2001)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
|
External Searches for GOLPH3L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GOLPH3L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GOLPH3L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GOLPH3L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GOLPH3L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GOLPH3L gene:
Search GeneIP for patents involving GOLPH3L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GOLPH3L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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 |
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| |
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| |  |  |  |  | | | | |
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 |
 |
 | | | GOLPH3L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOLPH3L |
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| |  | |
|
|
|
