Aliases for GOLPH3 Gene
External Ids for GOLPH3 Gene
Previous GeneCards Identifiers for GOLPH3 Gene
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a peripheral membrane protein of the Golgi stack and may have a regulatory role in Golgi trafficking. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for GOLPH3 Gene
GOLPH3 (Golgi Phosphoprotein 3) is a Protein Coding gene. Diseases associated with GOLPH3 include chronic sphenoidal sinusitis and migraine with or without aura 1. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include enzyme binding and phosphatidylinositol-4-phosphate binding. An important paralog of this gene is GOLPH3L.
UniProtKB/Swiss-Prot for GOLPH3 Gene
Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis.