Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GOLPH3 Gene

protein-coding   GIFtS: 59
GCID: GC05M032124

Golgi Phosphoprotein 3 (Coat-Protein)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Golgi Phosphoprotein 3 (Coat-Protein)1 2     Mitochondrial DNA Absence Factor2 3
GPP342 3 5     34 KDa1
MIDAS2 3 5     Golgi Peripheral Membrane Protein 11
coat-protein1 2     GOPP12
Golgi Protein1 2     Golgi Peripheral Membrane Protein 1, 34 KDa2
Golgi-Associated Protein1 2     Golgi Phosphoprotein 32
Coat Protein GPP342 3     

External Ids:    HGNC: 154521   Entrez Gene: 640832   Ensembl: ENSG000001133847   OMIM: 6122075   UniProtKB: Q9H4A63   

Export aliases for GOLPH3 gene to outside databases

Previous GC identifers: GC05M031912 GC05M032571 GC05M032170 GC05M032160 GC05M032091


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GOLPH3 Gene:
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic
reticulum. The protein encoded by this gene is a peripheral membrane protein of the Golgi stack and may have a
regulatory role in Golgi trafficking. Several alternatively spliced transcript variants of this gene have been
described, but the full-length nature of these variants has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for GOLPH3 Gene: 
GOLPH3 (golgi phosphoprotein 3 (coat-protein)) is a protein-coding gene. Diseases associated with GOLPH3 include sphenoid sinusitis, and specific phobia. GO annotations related to this gene include lipid binding and protein binding. An important paralog of this gene is GOLPH3L.

UniProtKB/Swiss-Prot: GOLP3_HUMAN, Q9H4A6
Function: Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their
cytosolic domains. Involved in modulation of mTOR signaling. Involved in the regulation of mitochondrial lipids,
leading to increase of mitochondrial mass. Potential oncogene




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006576.16  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GOLPH3 gene promoter:
         AP-2alpha isoform 3   ATF-2   AP-2alpha isoform 4   AP-2alpha isoform 2   c-Jun   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGOLPH3 promoter sequence
   Search SABiosciences Chromatin IP Primers for GOLPH3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GOLPH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.3   Ensembl cytogenetic band:  5p13.3   HGNC cytogenetic band: 5p13.2

GOLPH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GOLPH3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M032124:  view genomic region     (about GC identifiers)

Start:
32,124,810 bp from pter      End:
32,174,456 bp from pter
Size:
49,647 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GOLP3_HUMAN, Q9H4A6 (See protein sequence)
Recommended Name: Golgi phosphoprotein 3  
Size: 298 amino acids; 33811 Da
Subunit: Homodimer. Interacts with VPS35
Subcellular location: Cell membrane (By similarity). Endosome (By similarity). Cytoplasm. Golgi apparatus, Golgi
stack membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion intermembrane space.
Note=Phosphatidylinositol 4-phosphate (PtdIns4P) binding is essential for Golgi localization
Miscellaneous: Modulates sensitivity to rapamycin. Tumors expressing this protein are more sensitive to rapamycin
in vivo
1 PDB 3D structure from and Proteopedia for GOLPH3:
3KN1 (3D)    
Secondary accessions: Q9UIW5

Explore the universe of human proteins at neXtProt for GOLPH3: NX_Q9H4A6

Explore proteomics data for GOLPH3 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H4A6

  • GOLPH3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GOLPH3 Protein Expression
    REFSEQ proteins: NP_071413.1  
    ENSEMBL proteins: 
     ENSP00000265070   ENSP00000426752  

    Human Recombinant Protein Products for GOLPH3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GOLPH3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for GOLPH3
    GenScript Custom Purified and Recombinant Proteins Services for GOLPH3
    Novus Biologicals GOLPH3 Proteins
    Novus Biologicals GOLPH3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GOLPH3 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA16263763
    GO:0005758mitochondrial intermembrane space IEA--
    GO:0005768endosome IEA--
    GO:0005794Golgi apparatus ----

    GOLPH3 for ontologies           About GeneDecksing



    GOLPH3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for GOLPH3
    OriGene Custom Antibody Services for GOLPH3
    GenScript Custom Superior Antibodies Services for GOLPH3
    Novus Biologicals GOLPH3 Antibodies
    Abcam antibodies for GOLPH3
    Cloud-Clone Corp. Antibodies for GOLPH3 
    ThermoFisher Antibodies for GOLPH3
    LSBio Antibodies in human, mouse, rat for GOLPH3 

    Assay Products for GOLPH3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GOLPH3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GOLPH3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GOLPH3 
    Cloud-Clone Corp. CLIAs for GOLPH3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008628 GPP34

    Graphical View of Domain Structure for InterPro Entry Q9H4A6

    ProtoNet protein and cluster: Q9H4A6

    1 Blocks protein domain: IPB008628 Golgi phosphoprotein 3

    UniProtKB/Swiss-Prot: GOLP3_HUMAN, Q9H4A6
    Similarity: Belongs to the GOLPH3/VPS74 family


    GOLPH3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GOLP3_HUMAN, Q9H4A6
    Function: Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their
    cytosolic domains. Involved in modulation of mTOR signaling. Involved in the regulation of mitochondrial lipids,
    leading to increase of mitochondrial mass. Potential oncogene
    Induction: Activated by depletion of mitochondrial DNA

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19553991
    GO:0008289lipid binding ----
    GO:0019899enzyme binding IPI--
    GO:0070273phosphatidylinositol-4-phosphate binding IDA19837035
         
    GOLPH3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for GOLPH3:
     Decreased Tat-dependent transc  Increased G1 DNA content  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GOLPH3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GOLPH3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GOLPH3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GOLPH3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GOLPH3
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate GOLPH3 (see all 12):
    hsa-miR-498 hsa-miR-3163 hsa-miR-3164 hsa-miR-3673 hsa-miR-188-5p hsa-miR-634 hsa-miR-922 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidGOLPH3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GOLPH3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GOLPH3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GOLPH3
    Sirion Biotech Customized adenovirus for overexpression of GOLPH3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GOLPH3 (see all 9)
    OriGene ORF clones in mouse, rat for GOLPH3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GOLPH3 (NM_018178)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GOLPH3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GOLPH3
    Sirion Biotech Customized lentivirus for stable overexpression of GOLPH3 
                         Customized lentivirus expression plasmids for stable overexpression of GOLPH3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GOLPH3
    Search LifeMap BioReagents cell lines for GOLPH3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOLPH3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GOLPH3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for GOLPH3):
        Transcriptional misregulation in cancer


    GOLPH3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GOLPH3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/11 Interacting proteins for GOLPH3 (Q9H4A61, 3 ENSP000002650704) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYO18AQ926141, 3, ENSP000003462914EBI-2465479,EBI-949059 I2D: score=1 STRING: ENSP00000346291
    YWHAZP631043I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    COPAENSP000003570484STRING: ENSP00000357048
    COPB1ENSP000002499234STRING: ENSP00000249923
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007030Golgi organization IMP19837035
    GO:0008283cell proliferation IMP19553991
    GO:0009101glycoprotein biosynthetic process IMP--
    GO:0009306protein secretion IMP--
    GO:0010467gene expression IMP--

    GOLPH3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GOLPH3 (GOLP3)

    Search CenterWatch for drugs/clinical trials and news about GOLPH3 / GOLP3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GOLPH3 gene: 
    NM_022130.3  

    Unigene Cluster for GOLPH3:

    Golgi phosphoprotein 3 (coat-protein)
    Hs.408909  [show with all ESTs]
    Unigene Representative Sequence: BC033725
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265070(uc003jhp.1) ENST00000503610 ENST00000512668
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GOLPH3
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate GOLPH3 (see all 12):
    hsa-miR-498 hsa-miR-3163 hsa-miR-3164 hsa-miR-3673 hsa-miR-188-5p hsa-miR-634 hsa-miR-922 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidGOLPH3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GOLPH3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GOLPH3
    Clone
    Products:
         
    OriGene clones in human, mouse for GOLPH3 (see all 9)
    OriGene ORF clones in mouse, rat for GOLPH3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GOLPH3 (NM_018178)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GOLPH3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GOLPH3
    Sirion Biotech Customized lentivirus for stable overexpression of GOLPH3 
                         Customized lentivirus expression plasmids for stable overexpression of GOLPH3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GOLPH3
    OriGene qSTAR qPCR primer pairs in human, mouse for GOLPH3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GOLPH3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GOLPH3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GOLPH3

    Additional mRNA sequence: 

    AJ296152.1 AK057544.1 AK075077.1 AK075156.1 AK092604.1 AK293368.1 AK301588.1 AL133078.1 
    BC012123.1 BC033725.1 BC063586.1 

    23 DOTS entries:

    DT.100826038  DT.100042844  DT.100826043  DT.448120  DT.120867689  DT.101986351  DT.95161033  DT.100826045 
    DT.100826035  DT.120867726  DT.100679146  DT.100826031  DT.40219145  DT.100826034  DT.120867734  DT.97773870 
    DT.100041731  DT.100826037  DT.120867682  DT.95161031  DT.120867660  DT.92446294  DT.99956041 

    24/356 AceView cDNA sequences (see all 356):

    AW731695 BQ216026 BF792909 AW467467 AW072184 BQ225939 BE047336 BG014707 
    AA746406 AW299766 AL133078 N24149 AA721131 AA554914 AI358254 AI281274 
    AA370728 CB998179 CB850734 CR598328 AA384569 AI521984 BU732497 BM129222 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GOLPH3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
    SP1:                          -                           
    SP2:              -           -                           
    SP3:              -     -     -                           
    SP4:                                                      


    ECgene alternative splicing isoforms for GOLPH3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GOLPH3 expression in normal human tissues (normalized intensities)      GOLPH3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAATAGTGG
    GOLPH3 Expression
    About this image


    GOLPH3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             bone marrow cd34+   
     
     Limb (Muscoskeletal System)
             Limb Bud
     
     Umbilical Cord (Extraembryonic Tissues)
             stem cells (umbilical cord cd34+)   
     
     Skeletal Muscle (Muscoskeletal System)
             gastrocnemius muscle   
     
     Lower Urinary Tract (Urinary System)
             bladder   

    See GOLPH3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GOLPH3

    SOURCE GeneReport for Unigene cluster: Hs.408909

    UniProtKB/Swiss-Prot: GOLP3_HUMAN, Q9H4A6
    Tissue specificity: Detected in muscle fibers of patients with mitochondrial diseases; not detected in normal
    muscle fibers

        SABiosciences Custom PCR Arrays for GOLPH3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GOLPH3
    OriGene qSTAR qPCR primer pairs in human, mouse for GOLPH3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GOLPH3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GOLPH3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GOLPH3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOLPH3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GOLPH3 gene from 8/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Golph31 , 5 golgi phosphoprotein 31, 5 92.84(n)1
    98.66(a)1
      15 (5.90 cM)5
    666291  NM_025673.21  NP_079949.11 
     123214965 
    chicken
    (Gallus gallus)
    Aves GOLPH31 golgi phosphoprotein 3 (coat-protein) 84.53(n)
    95.9(a)
      427422  XM_424995.3  XP_424995.3 
    lizard
    (Anolis carolinensis)
    Reptilia GOLPH36
    golgi phosphoprotein 3 (coat-protein)
    81(a)
    1 ↔ 1
    GL343335.1(235661-279733)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.115512 Xenopus laevis transcribed sequence with moderate similarity more 81.54(n)    AW645216.1 
    zebrafish
    (Danio rerio)
    Actinopterygii golph32 golgi phosphoprotein 3 76.95(n)   324210  CK017905.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)s53791 lethal (2) s5379 66.55(n)
    72.92(a)
      33402  NM_001014460.2  NP_001014460.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y47G6A.183
    CELE_Y47G6A.181
    Protein Y47G6A.181 63(a)3
    62.79(n)1
    71.64(a)1
      I(3509714-3512661)3
    1719191  NM_058771.21  NP_491172.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS74(YDR372C)4
    VPS741
    Protein required for Golgi localization of glycosyltransferases; more4
    Vps74p1
    50.96(n)1
    43.3(a)1
      4(1222149-1221112)4
    8519781, 4  NP_010660.11, 4 


    ENSEMBL Gene Tree for GOLPH3 (if available)
    TreeFam Gene Tree for GOLPH3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GOLPH3 gene
    GOLPH3L2  
    1 SIMAP similar gene for GOLPH3 using alignment to 3 protein entries:     GOLP3_HUMAN (see all proteins):
    GOLPH3L

    GOLPH3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1083 SNPs in GOLPH3 are shown (see all 1083)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1454002601,2
    --32124335(+) TCTATA/TACCTC 1 -- ds50010--------
    rs1442978091,2
    --32124383(+) TCACTC/TGATAA 1 -- ds50010--------
    rs1486556711,2
    --32124408(+) CTGGTA/TTCAGT 1 -- ds50010--------
    rs1897137211,2
    C--32124434(+) TTATGA/GGAAGA 1 -- ds50010--------
    rs1421857231,2
    C--32124437(+) TGGGAA/GGACAC 1 -- ds50010--------
    rs792812601,2
    C,F--32124764(+) AACATT/CTCATT 1 -- ds50011Minor allele frequency- C:0.04NA 120
    rs777029161,2
    C,F--32124789(+) ATGAGA/TATACA 1 -- ds50011Minor allele frequency- T:0.04NA 120
    rs1512168361,2
    C--32124793(+) GAATAC/TAAAAA 1 -- ds50010--------
    rs174352311,2
    C,F,H--32125032(+) AATTTG/ATTCAA 1 -- ut3111Minor allele frequency- A:0.01NA NS EA 1056
    rs1822403431,2
    --32125308(+) ACATTG/TCAGAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for GOLPH3 (32124810 - 32174456 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/22 variations for GOLPH3 (see all 22):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667263CNV Deletion23128226
    nsv328059CNV Insertion16902084
    nsv830251CNV Loss17160897
    dgv54n64CNV Gain17921354
    esv33235CNV Gain17666407
    dgv6027n71CNV Gain21882294
    dgv201e55CNV Gain17911159
    dgv202e55CNV Gain17911159
    nsv881577CNV Gain21882294
    nsv517387CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GOLPH3
    DNA2.0 Custom Variant and Variant Library Synthesis for GOLPH3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612207    OMIM disorders: --

    20 diseases for GOLPH3:    About MalaCards
    sphenoid sinusitis    specific phobia    focal dermal hypoplasia    patent foramen ovale
    borderline personality disorder    aids dementia complex    toxic encephalopathy    mouth disease
    personality disorder    sinusitis    tongue cancer    microphthalmia
    migraine    dementia    rhabdomyosarcoma    influenza
    hepatitis c    schizophrenia    hepatitis    breast cancer

    6 diseases from the University of Copenhagen DISEASES database for GOLPH3:
    Migraine     Patent foramen ovale     Specific phobia     Borderline personality disorder
    Focal dermal hypoplasia     Microphthalmia

    GOLPH3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GOLPH3
    Human Genome Epidemiology (HuGE) Navigator: GOLPH3 (2 documents)

    Export disorders for GOLPH3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GOLPH3 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with GOLPH3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MIDAS/GPP34, a nuclear gene product, regulates total mitochondrial mass in response to mitochondrial dysfunction. (PubMed id 16263763)1, 2, 3 Nakashima-Kamimura N.... Ohta S. (2005)
    2. Proteomics characterization of abundant Golgi membrane proteins. (PubMed id 11042173)1, 2, 3 Bell A.W....Bergeron J.J.M. (2001)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. PtdIns4P recognition by Vps74/GOLPH3 links PtdIns 4-k inase signaling to retrograde Golgi trafficking. (PubMed id 20026658)1, 2 Wood C.S....Burd C.G. (2009)
    5. GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer. (PubMed id 19553991)1, 2 Scott K.L.... Chin L. (2009)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. GOLPH3L antagonizes GOLPH3 to determine Golgi morpholo gy. (PubMed id 23345592)1 Ng M.M....Field S.J. (2013)
    9. Overexpression of GOLPH3 is associated with poor clini cal outcome in gastric cancer. (PubMed id 23132295)1 Hu B.S....Li J.P. (2013)
    10. GOLPH3 regulates the migration and invasion of glioma cells though RhoA. (PubMed id 23500462)1 Zhou X....Yu R. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64083 HGNC: 15452 AceView: GOLPH3 Ensembl:ENSG00000113384 euGenes: HUgn64083
    ECgene: GOLPH3 Kegg: 64083 H-InvDB: GOLPH3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GOLPH3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GOLPH3 gene:
    Search GeneIP for patents involving GOLPH3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GOLPH3   OriGene RNAi products in human, mouse, rat for GOLPH3  
     OriGene qPCR primer pairs and template standards for GOLPH3   OriGene Protein Over-expression Lysate for GOLPH3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GOLPH3  
     OriGene qSTAR qPCR primer pairs in human, mouse for GOLPH3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GOLPH3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GOLPH3   OriGene Custom Protein Services for GOLPH3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GOLPH3
     QIAGEN SeqTarget long-range PCR primers for resequencing GOLPH3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GOLPH3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GOLPH3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GOLPH3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GOLPH3
     GenScript Custom Purified and Recombinant Proteins Services for GOLPH3 GenScript cDNA clones with any tag delivered in your preferred vector for GOLPH3
     GenScript Custom Assay Services for GOLPH3 GenScript Custom Superior Antibodies Services for GOLPH3
     GenScript Custom overexpressing Cell Line Services for GOLPH3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GOLPH3 promoter
     Search Chromatin IP Primers for GOLPH3
     RT2 qPCR Primer Assay in human, mouse, rat GOLPH3
     GNC Network for GOLPH3
     SABiosciences Custom PCR Arrays for GOLPH3
     Search Tocris compounds for GOLPH3 (GOLP3)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GOLPH3 antibodies
     GOLPH3 proteins
     GOLPH3 lysates
     Antibodies for GOLPH3
     See all of Abcam's Antibodies, Kits and Proteins for GOLPH3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for GOLPH3
     Antibodies for GOLPH3
     ELISAs for GOLPH3
     CLIAs for GOLPH3
     Search LifeMap BioReagents cell lines for GOLPH3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOLPH3
     SwitchGear 3'UTR luciferase reporter plasmids for GOLPH3
     SwitchGear Promoter luciferase reporter plasmids for GOLPH3
     ThermoFisher Antibodies for GOLPH3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GOLPH3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GOLPH3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GOLPH3
    Customized:
     lentivirus for stable overexpression of GOLPH3
     lentivirus expression plasmids for stable overexpression of GOLPH3
     adenovirus for overexpression of GOLPH3
     LSBio Antibodies in human, mouse, rat for GOLPH3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GOLPH3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4