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Aliases for GOLM1 Gene

Aliases for GOLM1 Gene

  • Golgi Membrane Protein 1 2 3 5
  • Golgi Phosphoprotein 2 2 3 4
  • Golgi Membrane Protein GP73 3 4
  • C9orf155 3 4
  • GOLPH2 3 4
  • Chromosome 9 Open Reading Frame 155 2
  • Epididymis Luminal Protein 46 3
  • Golgi Protein, 73-KD 3
  • BA379P1.3 3
  • PSEC0257 3
  • HEL46 3
  • GP73 3

External Ids for GOLM1 Gene

Previous HGNC Symbols for GOLM1 Gene

  • GOLPH2
  • C9orf155

Previous GeneCards Identifiers for GOLM1 Gene

  • GC09M087832
  • GC09M088641
  • GC09M058466

Summaries for GOLM1 Gene

Entrez Gene Summary for GOLM1 Gene

  • The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for GOLM1 Gene

GOLM1 (Golgi Membrane Protein 1) is a Protein Coding gene. Diseases associated with GOLM1 include Liver Disease. An important paralog of this gene is CASC4.

UniProtKB/Swiss-Prot for GOLM1 Gene

  • Unknown. Cellular response protein to viral infection.

Gene Wiki entry for GOLM1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLM1 Gene

Genomics for GOLM1 Gene

Regulatory Elements for GOLM1 Gene

Enhancers for GOLM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G086092 1.2 Ensembl ENCODE 56.5 +6.2 6165 3.7 PKNOX1 FOXA2 ATF1 MLX ARID4B SIN3A ZNF48 YY1 FOS SP5 GOLM1 PIR41563
GH09G086098 0.9 ENCODE 56.7 +0.5 486 2.2 ZFP64 SIN3A BMI1 ZNF2 ZNF48 GLIS2 GATAD2B ZNF398 HNF4A MYC GOLM1 PIR41563
GH09G086126 1.2 Ensembl ENCODE 18.3 -27.6 -27649 2.9 PKNOX1 FEZF1 ZNF2 TCF12 GLIS2 FOS KLF7 ZNF548 SP3 REST GOLM1 LOC100130049 GC09P086133 LOC101927623 LOC100287212
GH09G086062 1 Ensembl ENCODE 16.2 +36.9 36857 1.7 ZNF263 ELF3 ZNF621 ZFP64 KLF17 CEBPB NFXL1 SALL2 ZNF398 EP300 GOLM1 C9orf153 RN7SKP264 GC09M086071 PIR41548
GH09G086074 0.5 ENCODE 22.8 +24.9 24878 0.8 SOX13 NFIL3 PPARG GOLM1 GC09M086071 PIR41563
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GOLM1 on UCSC Golden Path with GeneCards custom track

Promoters for GOLM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000237028 801 2001 ZFP64 BMI1 ZNF2 RAD21 ZNF48 GLIS2 GATAD2B SMARCA4 HNF4A ZBTB26

Transcription factor binding sites by QIAGEN in the GOLM1 gene promoter:

Genomic Location for GOLM1 Gene

Chromosome:
9
Start:
86,026,141 bp from pter
End:
86,100,201 bp from pter
Size:
74,061 bases
Orientation:
Minus strand

Genomic View for GOLM1 Gene

Genes around GOLM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLM1 Gene

Proteins for GOLM1 Gene

  • Protein details for GOLM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBJ4-GOLM1_HUMAN
    Recommended name:
    Golgi membrane protein 1
    Protein Accession:
    Q8NBJ4
    Secondary Accessions:
    • Q6IAF4
    • Q9NRB9

    Protein attributes for GOLM1 Gene

    Size:
    401 amino acids
    Molecular mass:
    45333 Da
    Quaternary structure:
    • Interacts with DYM.

    Alternative splice isoforms for GOLM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOLM1 Gene

Post-translational modifications for GOLM1 Gene

  • Glycosylated.
  • Phosphorylation sites are present in the extracellular medium.
  • Ubiquitination at posLast=125125
  • Glycosylation at isoforms=2109, isoforms=2144, posLast=218218, isoforms=2231, isoforms=2233, isoforms=2235, isoforms=2239, and isoforms=2398
  • Modification sites at PhosphoSitePlus

Other Protein References for GOLM1 Gene

No data available for DME Specific Peptides for GOLM1 Gene

Domains & Families for GOLM1 Gene

Protein Domains for GOLM1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8NBJ4

UniProtKB/Swiss-Prot:

GOLM1_HUMAN :
  • Belongs to the GOLM1/CASC4 family.
Family:
  • Belongs to the GOLM1/CASC4 family.
genes like me logo Genes that share domains with GOLM1: view

No data available for Gene Families for GOLM1 Gene

Function for GOLM1 Gene

Molecular function for GOLM1 Gene

UniProtKB/Swiss-Prot Function:
Unknown. Cellular response protein to viral infection.
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to viral infection. Induced by the E1A adenoviral protein.

Gene Ontology (GO) - Molecular Function for GOLM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21280149
genes like me logo Genes that share ontologies with GOLM1: view
genes like me logo Genes that share phenotypes with GOLM1: view

Animal Model Products

CRISPR Products

miRNA for GOLM1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLM1 Gene

Localization for GOLM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLM1 Gene

Golgi apparatus, cis-Golgi network membrane; Single-pass type II membrane protein. Note=Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLM1 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GOLM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005794 Golgi apparatus TAS,IDA --
GO:0005887 integral component of plasma membrane TAS 10831838
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GOLM1: view

Pathways & Interactions for GOLM1 Gene

SuperPathways for GOLM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GOLM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006997 nucleus organization IEA --
GO:0019216 regulation of lipid metabolic process IEA --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with GOLM1: view

No data available for Pathways by source and SIGNOR curated interactions for GOLM1 Gene

Drugs & Compounds for GOLM1 Gene

(1) Additional Compounds for GOLM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GOLM1: view

Transcripts for GOLM1 Gene

Unigene Clusters for GOLM1 Gene

Golgi membrane protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOLM1 Gene

No ASD Table

Relevant External Links for GOLM1 Gene

GeneLoc Exon Structure for
GOLM1
ECgene alternative splicing isoforms for
GOLM1

Expression for GOLM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GOLM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GOLM1 Gene

This gene is overexpressed in Adrenal Gland (x4.5).

Protein differential expression in normal tissues from HIPED for GOLM1 Gene

This gene is overexpressed in Nasal epithelium (26.5) and Oral epithelium (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GOLM1 Gene



NURSA nuclear receptor signaling pathways regulating expression of GOLM1 Gene:

GOLM1

SOURCE GeneReport for Unigene cluster for GOLM1 Gene:

Hs.494337

mRNA Expression by UniProt/SwissProt for GOLM1 Gene:

Q8NBJ4-GOLM1_HUMAN
Tissue specificity: Widely expressed. Highly expressed in colon, prostate, trachea and stomach. Expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen. Predominantly expressed by cells of the epithelial lineage. Expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), it is strongly expressed in hepatocytes-derived syncytial giant cells. Constitutively expressed by biliary epithelial cells but not by hepatocytes.

Evidence on tissue expression from TISSUES for GOLM1 Gene

  • Liver(4.6)
  • Eye(4.2)
  • Bone marrow(4.1)
  • Nervous system(4.1)
  • Saliva(4)
  • Intestine(2.6)
  • Stomach(2.4)
  • Gall bladder(2)
  • Lung(2)
genes like me logo Genes that share expression patterns with GOLM1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLM1 Gene

Orthologs for GOLM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GOLM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOLM1 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GOLM1 34 35
  • 85.2 (n)
cow
(Bos Taurus)
Mammalia GOLM1 34 35
  • 85.04 (n)
rat
(Rattus norvegicus)
Mammalia Golm1 34
  • 77.75 (n)
mouse
(Mus musculus)
Mammalia Golm1 34 16 35
  • 75.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 72 (a)
OneToMany
-- 35
  • 54 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia GOLM1 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves GOLM1 34 35
  • 60.82 (n)
lizard
(Anolis carolinensis)
Reptilia GOLM1 35
  • 46 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15706 34
zebrafish
(Danio rerio)
Actinopterygii GOLM1 35
  • 23 (a)
OneToOne
Species where no ortholog for GOLM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GOLM1 Gene

ENSEMBL:
Gene Tree for GOLM1 (if available)
TreeFam:
Gene Tree for GOLM1 (if available)

Paralogs for GOLM1 Gene

Paralogs for GOLM1 Gene

(2) SIMAP similar genes for GOLM1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for GOLM1 Gene

genes like me logo Genes that share paralogs with GOLM1: view

Variants for GOLM1 Gene

Sequence variations from dbSNP and Humsavar for GOLM1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000014808 -- 86,070,954(+) ATGTA(C/T)AACCA intron-variant
rs1000059582 -- 86,072,276(+) AAATA(A/G)TATCT intron-variant
rs1000068250 -- 86,057,811(+) TCTGT(C/T)CCGAG intron-variant
rs1000102316 -- 86,029,231(+) CTAAA(G/T)ATTCC intron-variant
rs1000114713 -- 86,052,145(+) CAAAG(A/G)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GOLM1 Gene

Variant ID Type Subtype PubMed ID
dgv4465e59 CNV duplication 20981092
esv2622889 CNV insertion 19546169
esv2673538 CNV deletion 23128226
esv2738686 CNV deletion 23290073
esv3380912 CNV insertion 20981092
esv3620950 CNV loss 21293372
nsv1128501 CNV deletion 24896259
nsv1137475 CNV deletion 24896259
nsv510198 OTHER sequence alteration 20534489
nsv6594 CNV insertion 18451855
nsv819703 CNV insertion 19587683

Variation tolerance for GOLM1 Gene

Residual Variation Intolerance Score: 86.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GOLM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLM1 Gene

Disorders for GOLM1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GOLM1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
liver disease
  • disorder of liver
- elite association - COSMIC cancer census association via MalaCards
Search GOLM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GOLM1

Genetic Association Database (GAD)
GOLM1
Human Genome Epidemiology (HuGE) Navigator
GOLM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GOLM1
genes like me logo Genes that share disorders with GOLM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GOLM1 Gene

Publications for GOLM1 Gene

  1. GP73, a novel Golgi-localized protein upregulated by viral infection. (PMID: 10831838) Kladney R.D. … Fimmel C.J. (Gene 2000) 2 3 4 22 64
  2. Expression of GP73, a resident Golgi membrane protein, in viral and nonviral liver disease. (PMID: 12029628) Kladney R.D. … Fimmel C.J. (Hepatology 2002) 3 4 22 64
  3. Upregulation of the Golgi protein GP73 by adenovirus infection requires the E1A CtBP interaction domain. (PMID: 12359426) Kladney R.D. … Fimmel C.J. (Virology 2002) 3 4 22 64
  4. Cloning and characterization of human Golgi phosphoprotein 2 gene (GOLPH2/GP73/GOLM1) promoter. (PMID: 22542941) Gong Y. … Peng T. (Biochem. Biophys. Res. Commun. 2012) 2 3 64
  5. Dymeclin, the gene underlying Dyggve-Melchior-Clausen syndrome, encodes a protein integral to extracellular matrix and Golgi organization and is associated with protein secretion pathways critical in bone development. (PMID: 21280149) Denais C. … Machado R.D. (Hum. Mutat. 2011) 3 4 64

Products for GOLM1 Gene

Sources for GOLM1 Gene

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