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Aliases for GOLM1 Gene

Aliases for GOLM1 Gene

  • Golgi Membrane Protein 1 2 3
  • Golgi Phosphoprotein 2 2 3 4
  • GOLPH2 3 4 6
  • Golgi Membrane Protein GP73 3 4
  • C9orf155 3 4
  • GP73 3 6
  • Chromosome 9 Open Reading Frame 155 2
  • Epididymis Luminal Protein 46 3
  • Golgi Protein, 73-KD 3
  • BA379P1.3 3
  • PSEC0257 3
  • HEL46 3

External Ids for GOLM1 Gene

Previous Symbols for GOLM1 Gene

  • GOLPH2
  • C9orf155

Summaries for GOLM1 Gene

Entrez Gene Summary for GOLM1 Gene

  • The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for GOLM1 Gene

GOLM1 (Golgi Membrane Protein 1) is a Protein Coding gene. An important paralog of this gene is CASC4.

UniProtKB/Swiss-Prot for GOLM1 Gene

  • Unknown. Cellular response protein to viral infection

Gene Wiki entry for GOLM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLM1 Gene

Genomics for GOLM1 Gene

Genomic Location for GOLM1 Gene

Start:
86,026,141 bp from pter
End:
86,100,201 bp from pter
Size:
74,061 bases
Orientation:
Minus strand

Genomic View for GOLM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GOLM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLM1 Gene

Regulatory Elements for GOLM1 Gene

Transcription factor binding sites by QIAGEN in the GOLM1 gene promoter:

Proteins for GOLM1 Gene

  • Protein details for GOLM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBJ4-GOLM1_HUMAN
    Recommended name:
    Golgi membrane protein 1
    Protein Accession:
    Q8NBJ4
    Secondary Accessions:
    • Q6IAF4
    • Q9NRB9

    Protein attributes for GOLM1 Gene

    Size:
    401 amino acids
    Molecular mass:
    45333 Da
    Quaternary structure:
    • Interacts with DYM.

    Alternative splice isoforms for GOLM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOLM1 Gene

Proteomics data for GOLM1 Gene at MOPED

Post-translational modifications for GOLM1 Gene

Other Protein References for GOLM1 Gene

No data available for DME Specific Peptides for GOLM1 Gene

Domains for GOLM1 Gene

Protein Domains for GOLM1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

GOLM1_HUMAN
Family:
  • Belongs to the GOLM1/CASC4 family.:
    • Q8NBJ4
genes like me logo Genes that share domains with GOLM1: view

No data available for Gene Families for GOLM1 Gene

Function for GOLM1 Gene

Molecular function for GOLM1 Gene

UniProtKB/Swiss-Prot Function: Unknown. Cellular response protein to viral infection
UniProtKB/Swiss-Prot Induction: Up-regulated in response to viral infection. Induced by the E1A adenoviral protein.

Gene Ontology (GO) - Molecular Function for GOLM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21280149
genes like me logo Genes that share ontologies with GOLM1: view
genes like me logo Genes that share phenotypes with GOLM1: view

miRNA for GOLM1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GOLM1 Gene

Localization for GOLM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLM1 Gene

Golgi apparatus, cis-Golgi network membrane; Single-pass type II membrane protein. Note=Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GOLM1 Gene COMPARTMENTS Subcellular localization image for GOLM1 gene
Compartment Confidence
golgi apparatus 4
plasma membrane 4
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GOLM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005794 Golgi apparatus IDA --
GO:0005887 integral component of plasma membrane TAS 10831838
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with GOLM1: view

Pathways for GOLM1 Gene

SuperPathways for GOLM1 Gene

No Data Available

Interacting Proteins for GOLM1 Gene

Gene Ontology (GO) - Biological Process for GOLM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006997 nucleus organization IEA --
GO:0019216 regulation of lipid metabolic process IEA --
genes like me logo Genes that share ontologies with GOLM1: view

No data available for Pathways by source for GOLM1 Gene

Compounds for GOLM1 Gene

(1) Novoseek inferred chemical compound relationships for GOLM1 Gene

Compound -log(P) Hits PubMed IDs
gp-7,3 98.4 42
genes like me logo Genes that share compounds with GOLM1: view

Transcripts for GOLM1 Gene

Unigene Clusters for GOLM1 Gene

Golgi membrane protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GOLM1 Gene

No ASD Table

Relevant External Links for GOLM1 Gene

GeneLoc Exon Structure for
GOLM1
ECgene alternative splicing isoforms for
GOLM1

Expression for GOLM1 Gene

mRNA expression in normal human tissues for GOLM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GOLM1 Gene

This gene is overexpressed in Adrenal Gland (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GOLM1 Gene

SOURCE GeneReport for Unigene cluster for GOLM1 Gene Hs.494337

mRNA Expression by UniProt/SwissProt for GOLM1 Gene

Q8NBJ4-GOLM1_HUMAN
Tissue specificity: Widely expressed. Highly expressed in colon, prostate, trachea and stomach. Expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen. Predominantly expressed by cells of the epithelial lineage. Expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), it is strongly expressed in hepatocytes-derived syncytial giant cells. Constitutively expressed by biliary epithelial cells but not by hepatocytes.
genes like me logo Genes that share expressions with GOLM1: view

Orthologs for GOLM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GOLM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOLM1 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GOLM1 36
  • 85.04 (n)
  • 82.29 (a)
GOLM1 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GOLM1 36
  • 85.2 (n)
  • 82.04 (a)
GOLM1 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Golm1 36
  • 75.83 (n)
  • 67.28 (a)
Golm1 16
Golm1 37
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GOLM1 37
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 54 (a)
OneToMany
-- 37
  • 72 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Golm1 36
  • 77.75 (n)
  • 70.36 (a)
chicken
(Gallus gallus)
Aves GOLM1 36
  • 60.82 (n)
  • 54.97 (a)
GOLM1 37
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GOLM1 37
  • 46 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15706 36
zebrafish
(Danio rerio)
Actinopterygii GOLM1 37
  • 23 (a)
OneToOne
Species with no ortholog for GOLM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GOLM1 Gene

ENSEMBL:
Gene Tree for GOLM1 (if available)
TreeFam:
Gene Tree for GOLM1 (if available)

Paralogs for GOLM1 Gene

Paralogs for GOLM1 Gene

Selected SIMAP similar genes for GOLM1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for GOLM1 Gene

genes like me logo Genes that share paralogs with GOLM1: view

Variants for GOLM1 Gene

Sequence variations from dbSNP and Humsavar for GOLM1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs13892 -- 86,026,907(-) TCATT(A/G)ATGTC utr-variant-3-prime
rs957617 -- 86,083,758(-) AGTTC(A/G)TAAAC intron-variant
rs1887878 -- 86,097,323(-) AAAAA(A/C)GTAGA intron-variant
rs1928226 -- 86,040,498(+) GCTGG(C/G)TGCGA intron-variant
rs1928227 -- 86,083,676(+) agcca(A/C)catgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GOLM1 Gene

Variant ID Type Subtype PubMed ID
esv2738686 CNV Deletion 23290073
nsv819703 CNV Insertion 19587683
esv2622889 CNV Insertion 19546169
nsv510198 CNV Loss 20534489
esv2673538 CNV Deletion 23128226
nsv6594 CNV Insertion 18451855
nsv893536 CNV Gain 21882294

Relevant External Links for GOLM1 Gene

HapMap Linkage Disequilibrium report
GOLM1

Disorders for GOLM1 Gene

(4) Novoseek inferred disease relationships for GOLM1 Gene

Disease -log(P) Hits PubMed IDs
hepatitis autoimmune 61.3 3
hepatitis 44.4 4
liver diseases 30.5 6
virus infection 19.7 2

Relevant External Links for GOLM1

Genetic Association Database (GAD)
GOLM1
Human Genome Epidemiology (HuGE) Navigator
GOLM1
genes like me logo Genes that share disorders with GOLM1: view

No data available for UniProtKB/Swiss-Prot for GOLM1 Gene

Publications for GOLM1 Gene

  1. GP73, a novel Golgi-localized protein upregulated by viral infection. (PMID: 10831838) Kladney R.D. … Fimmel C.J. (Gene 2000) 2 3 4 23
  2. Expression of GP73, a resident Golgi membrane protein, in viral and nonviral liver disease. (PMID: 12029628) Kladney R.D. … Fimmel C.J. (Hepatology 2002) 3 4 23
  3. Upregulation of the Golgi protein GP73 by adenovirus infection requires the E1A CtBP interaction domain. (PMID: 12359426) Kladney R.D. … Fimmel C.J. (Virology 2002) 3 4 23
  4. GOLPH2 protein expression as a novel tissue biomarker for prostate cancer: implications for tissue-based diagnostics. (PMID: 18781151) Kristiansen G. … Moch H. (Br. J. Cancer 2008) 3 23
  5. Golgi phosphoprotein 2 (GOLPH2) expression in liver tumors and its value as a serum marker in hepatocellular carcinomas. (PMID: 19291786) Riener M.O. … Kristiansen G. (Hepatology 2009) 3 23

Products for GOLM1 Gene

Sources for GOLM1 Gene

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