Aliases for GOLIM4 Gene
Aliases for GOLIM4 Gene
External Ids for GOLIM4 Gene
- HGNC: 15448
- Entrez Gene: 27333
- Ensembl: ENSG00000173905
- OMIM: 606805
- UniProtKB: O00461
Previous HGNC Symbols for GOLIM4 Gene
- GOLPH4
Previous GeneCards Identifiers for GOLIM4 Gene
- GC03M169210
- GC03M167727
- GC03M165097
Summaries for GOLIM4 Gene
-
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi-resident protein. It may process proteins synthesized in the rough endoplasmic reticulum and assist in the transport of protein cargo through the Golgi apparatus. [provided by RefSeq, Jul 2008]
GeneCards Summary for GOLIM4 Gene
GOLIM4 (Golgi Integral Membrane Protein 4) is a Protein Coding gene. Diseases associated with GOLIM4 include Pharynx Cancer and Myasthenic Syndrome, Congenital, 5. Among its related pathways are Intra-Golgi traffic and Vesicle-mediated transport.
UniProtKB/Swiss-Prot for GOLIM4 Gene
-
Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLIM4 Gene
Genomics for GOLIM4 Gene
Regulatory Elements for GOLIM4 Gene
Enhancers for GOLIM4 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH03G168047 | 0.8 | ENCODE | 13 | +48.6 | 48588 | 0.2 | TBP PKNOX1 RB1 ARID4B ZNF2 ZSCAN9 RAD21 RFX5 YY1 ZNF366 | GOLIM4 HMGN2P26 |
| GH03G168051 | 0.8 | FANTOM5 | 13 | +44.3 | 44262 | 0.2 | ZNF366 CBX5 EED ETV6 IKZF2 CREM ZNF362 MTA2 ZBED1 JUNB | GOLIM4 HMGN2P26 |
| GH03G168049 | 0.7 | Ensembl | 13 | +46.7 | 46674 | 0.6 | BHLHE40 ZEB2 ZNF394 YY1 ZFHX2 JUND PRDM6 ZBTB48 ZNF629 MAFK | GOLIM4 HMGN2P26 |
| GH03G168024 | 0.9 | Ensembl ENCODE | 6.5 | +71.1 | 71117 | 1.7 | JUN SIN3A MAX JUND ZNF316 POLR2A SMARCA4 FOS MAFK MYC | GOLIM4 HMGN2P26 |
| GH03G168090 | 1.2 | ENCODE | 0.7 | +1.7 | 1748 | 6.6 | CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC | HMGN1P8 SERPINI2 GOLIM4 HMGN2P26 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around GOLIM4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the GOLIM4 gene promoter:
Regulatory Element Products
Genomic Location for GOLIM4 Gene
- Chromosome:
- 3
- Start:
- 168,008,669 bp from pter
- End:
- 168,095,975 bp from pter
- Size:
- 87,307 bases
- Orientation:
- Minus strand
Genomic View for GOLIM4 Gene
Genes around GOLIM4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q26.2 by Ensembl
- 3q26.2 by Entrez Gene
- 3q26.2 by HGNC
GOLIM4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GOLIM4 Gene
Proteins for GOLIM4 Gene
-
Protein details for GOLIM4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00461-GOLI4_HUMAN
- Recommended name:
- Golgi integral membrane protein 4
- Protein Accession:
- O00461
Protein attributes for GOLIM4 Gene
- Size:
- 696 amino acids
- Molecular mass:
- 81880 Da
- Quaternary structure:
- No Data Available
Protein Expression for GOLIM4 Gene
Post-translational modifications for GOLIM4 Gene
- N-glycosylated; N-glycans are probably of the complex type and modified by sialic acid residues.
- O-glycosylated; modified by sialic acid residues.
- Phosphorylated probably by c-AMP-dependent kinases in its lumenal part.
- Glycosylation at posLast=194194, posLast=216216, posLast=229229, posLast=257257, posLast=270270, isoforms=276, isoforms=283, posLast=302302, isoforms=308, isoforms=396, and posLast=405405
- Modification sites at PhosphoSitePlus
Other Protein References for GOLIM4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for GOLIM4
- Novus Biologicals Antibodies for GOLIM4
- Invitrogen Antibodies for GOLIM4
- antibodies-online Antibodies for GOLIM4: See all 21
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-
Santa Cruz Biotechnology (SCBT) Antibodies for GOLIM4
Protein Products
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- antibodies-online Proteins for GOLIM4: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for GOLIM4
No data available for DME Specific Peptides for GOLIM4 Gene
Domains & Families for GOLIM4 Gene
Protein Domains for GOLIM4 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for GOLIM4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O00461- Family:
-
- Belongs to the GOLIM4 family.
No data available for Gene Families for GOLIM4 Gene
Function for GOLIM4 Gene
Molecular function for GOLIM4 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.
Phenotypes for GOLIM4 Gene
- GenomeRNAi human phenotypes for GOLIM4:
Animal Model Products
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-
-
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-
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CRISPR Products
-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for GOLIM4
- GenScript: Design CRISPR guide RNA sequences for GOLIM4
miRNA for GOLIM4 Gene
- miRTarBase miRNAs that target GOLIM4
-
- hsa-mir-149-5p (MIRT045671)
- hsa-mir-148a-3p (MIRT048034)
- hsa-mir-92a-3p (MIRT049004)
- hsa-mir-30e-3p (MIRT526475)
- hsa-mir-30d-3p (MIRT526476)
- hsa-mir-30a-3p (MIRT526477)
- hsa-mir-222-5p (MIRT526478)
- hsa-mir-556-3p (MIRT526479)
- hsa-mir-16-1-3p (MIRT526480)
- hsa-mir-487b-5p (MIRT548023)
- hsa-mir-487a-5p (MIRT548024)
- hsa-mir-4658 (MIRT548025)
- hsa-mir-6790-5p (MIRT548026)
- hsa-mir-4477a (MIRT548027)
- hsa-mir-1273g-5p (MIRT548028)
- hsa-mir-203a-5p (MIRT548029)
- hsa-mir-3659 (MIRT548030)
- hsa-mir-574-5p (MIRT548031)
- hsa-mir-4282 (MIRT548032)
- hsa-mir-3163 (MIRT548033)
- hsa-mir-8055 (MIRT548034)
- hsa-mir-105-3p (MIRT548035)
- hsa-mir-4468 (MIRT548036)
- hsa-mir-6806-5p (MIRT548037)
- hsa-mir-936 (MIRT548038)
- hsa-mir-5000-5p (MIRT548039)
- hsa-mir-449c-5p (MIRT548040)
- hsa-mir-34b-5p (MIRT548041)
- hsa-mir-2682-5p (MIRT548042)
- hsa-mir-940 (MIRT548043)
- hsa-mir-6808-5p (MIRT548044)
- hsa-mir-6893-5p (MIRT548045)
- hsa-mir-6511a-5p (MIRT548046)
- hsa-mir-1910-3p (MIRT548047)
- hsa-mir-646 (MIRT548048)
- hsa-mir-186-5p (MIRT548049)
- hsa-mir-3129-5p (MIRT548050)
- hsa-mir-199a-3p (MIRT548051)
- hsa-mir-199b-3p (MIRT548052)
- hsa-mir-6881-3p (MIRT643149)
- hsa-mir-6780a-3p (MIRT643150)
- hsa-mir-7111-3p (MIRT643151)
- hsa-mir-302a-5p (MIRT643152)
- hsa-mir-877-3p (MIRT643153)
- hsa-mir-10a-3p (MIRT643154)
miRNA Products
- Search ViGene Biosciences for GOLIM4
Inhibitory RNA Products
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-
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for GOLIM4
-
ViGene Biosciences adenoviral particle packaged cDNA for GOLIM4 gene
-
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-
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No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLIM4 Gene
Localization for GOLIM4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GOLIM4 Gene
- Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor. Note=Localizes to cis and medial Golgi cisternae. Probably cycles between early Golgi and distal compartments like endosome.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| endosome | 4 |
| extracellular | 3 |
| nucleus | 3 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005768 | endosome | IEA | -- |
| GO:0005794 | Golgi apparatus | IDA | -- |
| GO:0005796 | Golgi lumen | TAS | 9201717 |
| GO:0005801 | cis-Golgi network | TAS | 9201717 |
Pathways & Interactions for GOLIM4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Vesicle-mediated transport | ||
| 2 | Golgi-to-ER retrograde transport | ||
| 3 | Intra-Golgi traffic | ||
Pathways by source for GOLIM4 Gene
4 Reactome pathways for GOLIM4 Gene
Interacting Proteins for GOLIM4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
No data available for SIGNOR curated interactions for GOLIM4 Gene
Transcripts for GOLIM4 Gene
mRNA/cDNA for GOLIM4 Gene
- (5) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (113) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GOLIM4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GOLIM4
-
Santa Cruz Biotechnology (SCBT) CRISPR for GOLIM4
- GenScript: Design CRISPR guide RNA sequences for GOLIM4
miRNA Products
- Search ViGene Biosciences for GOLIM4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for GOLIM4
- Browse OriGene Inhibitory RNA Products For GOLIM4
-
ViGene Biosciences ready-to-package AAV shRNAs for GOLIM4 gene
Clone Products
-
OriGene ORF clones in human for GOLIM4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for GOLIM4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GOLIM4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||
| SP2: | - |
Expression for GOLIM4 Gene
This gene is overexpressed in Lavage (16.7), Vitreous humor (14.1), and Pancreas (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GOLIM4 Gene
NURSA nuclear receptor signaling pathways regulating expression of GOLIM4 Gene:
GOLIM4SOURCE GeneReport for Unigene cluster for GOLIM4 Gene:
Hs.143600Evidence on tissue expression from TISSUES for GOLIM4 Gene
- Intestine(4.4)
- Liver(4.4)
- Heart(2.3)
- Nervous system(2.1)
- Kidney(2)
- Spleen(2)
Primer Products
-
OriGene qPCR primer pairs for GOLIM4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLIM4 Gene
Orthologs for GOLIM4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GOLIM4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | GOLIM4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | GOLIM4 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Golim4 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Golim4 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GOLIM4 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GOLIM4 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GOLIM4 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | GOLIM4 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | golim4 34 |
|
||
| Str.10991 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.14113 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | golim4a 34 35 |
|
||
| golim4b 35 |
|
OneToMany | |||
| wufc54e03 34 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for GOLIM4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GOLIM4 Gene
No data available for Paralogs for GOLIM4 Gene
Variants for GOLIM4 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036611 | A breast cancer sample | ||||
| rs1000055971 | -- | 168,023,153(+) | GAACT(C/T)TTCTC | intron-variant | |
| rs1000062286 | -- | 168,033,485(+) | GCCTG(C/T)AGTCC | intron-variant | |
| rs1000142322 | -- | 168,048,166(+) | TCTGT(C/T)CACCT | intron-variant | |
| rs1000156834 | -- | 168,053,087(+) | ATTCC(C/T)CCCAA | intron-variant |
Residual Variation Intolerance Score:
29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.71;
73.18% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for GOLIM4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GOLIM4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLIM4 Gene
Disorders for GOLIM4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pharynx cancer |
|
|
| myasthenic syndrome, congenital, 5 |
|
|
| congenital myasthenic syndrome |
|
|
Search GOLIM4 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for GOLIM4
No data available for UniProtKB/Swiss-Prot and Genatlas for GOLIM4 Gene
Publications for GOLIM4 Gene
- Sequence and overexpression of GPP130/GIMPc: evidence for saturable pH-sensitive targeting of a type II early Golgi membrane protein. (PMID: 9201717) Linstedt A.D. … Hauri H.-P. (Mol. Biol. Cell 1997) 2 3 4 22 64
- Lumenal endosomal and Golgi-retrieval determinants involved in pH- sensitive targeting of an early Golgi protein. (PMID: 11598199) Bachert C. … Linstedt A.D. (Mol. Biol. Cell 2001) 3 4 22 64
- Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 46 64
- Both post-Golgi and intra-Golgi cycling affect the distribution of the Golgi phosphoprotein GPP130. (PMID: 17605763) Starr T. … Storrie B. (Traffic 2007) 3 22 64
- The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. (PMID: 15004235) Oka T. … Krieger M. (Mol. Biol. Cell 2004) 2 3 64
Products for GOLIM4 Gene
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- antibodies-online Antibodies for GOLIM4: See all 21
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- ViGene Biosciences adenoviral particle packaged cDNA for GOLIM4 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for GOLIM4
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- Santa Cruz Biotechnology (SCBT) CRISPR for GOLIM4
- Horizon Cell Lines for GOLIM4
- Cyagen custom Knockout/knockin (KOKI) mouse models for GOLIM4
- VectorBuilder custom plasmid, inducible vectors for GOLIM4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GOLIM4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for GOLIM4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
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