Aliases for GOLIM4 Gene
Aliases for GOLIM4 Gene
External Ids for GOLIM4 Gene
- HGNC: 15448
- Entrez Gene: 27333
- Ensembl: ENSG00000173905
- OMIM: 606805
- UniProtKB: O00461
Previous HGNC Symbols for GOLIM4 Gene
- GOLPH4
Previous GeneCards Identifiers for GOLIM4 Gene
- GC03M169210
- GC03M167727
- GC03M165097
Summaries for GOLIM4 Gene
-
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi-resident protein. It may process proteins synthesized in the rough endoplasmic reticulum and assist in the transport of protein cargo through the Golgi apparatus. [provided by RefSeq, Jul 2008]
GeneCards Summary for GOLIM4 Gene
GOLIM4 (Golgi Integral Membrane Protein 4) is a Protein Coding gene. Diseases associated with GOLIM4 include Nasopharynx Carcinoma and Pharynx Cancer. Among its related pathways are Golgi-to-ER retrograde transport and Vesicle-mediated transport.
UniProtKB/Swiss-Prot for GOLIM4 Gene
-
Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.
No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLIM4 Gene
Genomics for GOLIM4 Gene
Regulatory Elements for GOLIM4 Gene
Enhancers for GOLIM4 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around GOLIM4 on UCSC Golden Path with GeneCards custom track
Promoters for GOLIM4 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around GOLIM4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the GOLIM4 gene promoter:
Regulatory Element Products
Genomic Location for GOLIM4 Gene
- Chromosome:
- 3
- Start:
- 168,008,669 bp from pter
- End:
- 168,095,975 bp from pter
- Size:
- 87,307 bases
- Orientation:
- Minus strand
Genomic View for GOLIM4 Gene
Genes around GOLIM4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q26.2 by Ensembl
- 3q26.2 by Entrez Gene
- 3q26 by HGNC
GOLIM4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GOLIM4 Gene
Proteins for GOLIM4 Gene
-
Protein details for GOLIM4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00461-GOLI4_HUMAN
- Recommended name:
- Golgi integral membrane protein 4
- Protein Accession:
- O00461
Protein attributes for GOLIM4 Gene
- Size:
- 696 amino acids
- Molecular mass:
- 81880 Da
- Quaternary structure:
- No Data Available
Protein Expression for GOLIM4 Gene
Post-translational modifications for GOLIM4 Gene
- N-glycosylated; N-glycans are probably of the complex type and modified by sialic acid residues.
- O-glycosylated; modified by sialic acid residues.
- Phosphorylated probably by c-AMP-dependent kinases in its lumenal part.
- Glycosylation at Thr 194, Thr 216, Thr 229, Asn 257, Thr 270, Thr 276, Ser 283, Thr 302, Thr 308, Ser 396, and Ser 405
- Modification sites at PhosphoSitePlus
Other Protein References for GOLIM4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for GOLIM4
- antibodies-online Antibodies for GOLIM4: See all 21
- Search GeneTex for Antibodies for GOLIM4
-
Santa Cruz Biotechnology (SCBT) Antibodies for GOLIM4
Protein Products
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- antibodies-online Proteins for GOLIM4: See all 3
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Assay Products
No data available for DME Specific Peptides for GOLIM4 Gene
Domains & Families for GOLIM4 Gene
Protein Domains for GOLIM4 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for GOLIM4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O00461- Family:
-
- Belongs to the GOLIM4 family.
No data available for Gene Families for GOLIM4 Gene
Function for GOLIM4 Gene
Molecular function for GOLIM4 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.
Phenotypes for GOLIM4 Gene
- GenomeRNAi human phenotypes for GOLIM4:
Animal Model Products
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CRISPR Products
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-
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miRNA for GOLIM4 Gene
- miRTarBase miRNAs that target GOLIM4
-
- hsa-mir-149-5p (MIRT045671)
- hsa-mir-148a-3p (MIRT048034)
- hsa-mir-92a-3p (MIRT049004)
- hsa-mir-30e-3p (MIRT526475)
- hsa-mir-30d-3p (MIRT526476)
- hsa-mir-30a-3p (MIRT526477)
- hsa-mir-222-5p (MIRT526478)
- hsa-mir-556-3p (MIRT526479)
- hsa-mir-16-1-3p (MIRT526480)
- hsa-mir-487b-5p (MIRT548023)
- hsa-mir-487a-5p (MIRT548024)
- hsa-mir-4658 (MIRT548025)
- hsa-mir-6790-5p (MIRT548026)
- hsa-mir-4477a (MIRT548027)
- hsa-mir-1273g-5p (MIRT548028)
- hsa-mir-203a-5p (MIRT548029)
- hsa-mir-3659 (MIRT548030)
- hsa-mir-574-5p (MIRT548031)
- hsa-mir-4282 (MIRT548032)
- hsa-mir-3163 (MIRT548033)
- hsa-mir-8055 (MIRT548034)
- hsa-mir-105-3p (MIRT548035)
- hsa-mir-4468 (MIRT548036)
- hsa-mir-6806-5p (MIRT548037)
- hsa-mir-936 (MIRT548038)
- hsa-mir-5000-5p (MIRT548039)
- hsa-mir-449c-5p (MIRT548040)
- hsa-mir-34b-5p (MIRT548041)
- hsa-mir-2682-5p (MIRT548042)
- hsa-mir-940 (MIRT548043)
- hsa-mir-6808-5p (MIRT548044)
- hsa-mir-6893-5p (MIRT548045)
- hsa-mir-6511a-5p (MIRT548046)
- hsa-mir-1910-3p (MIRT548047)
- hsa-mir-646 (MIRT548048)
- hsa-mir-186-5p (MIRT548049)
- hsa-mir-3129-5p (MIRT548050)
- hsa-mir-199a-3p (MIRT548051)
- hsa-mir-199b-3p (MIRT548052)
- hsa-mir-6881-3p (MIRT643149)
- hsa-mir-6780a-3p (MIRT643150)
- hsa-mir-7111-3p (MIRT643151)
- hsa-mir-302a-5p (MIRT643152)
- hsa-mir-877-3p (MIRT643153)
- hsa-mir-10a-3p (MIRT643154)
miRNA Products
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Inhibitory RNA Products
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLIM4 Gene
Localization for GOLIM4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GOLIM4 Gene
- Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor. Note=Localizes to cis and medial Golgi cisternae. Probably cycles between early Golgi and distal compartments like endosome.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| nucleus | 5 |
| endosome | 4 |
| extracellular | 3 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| vacuole | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005796 | Golgi lumen | TAS | 9201717 |
| GO:0005801 | cis-Golgi network | TAS | 9201717 |
| GO:0010008 | endosome membrane | IEA | -- |
Pathways & Interactions for GOLIM4 Gene
More details on SuperPathways for GOLIM4| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Vesicle-mediated transport | ||
| 2 | Golgi-to-ER retrograde transport | ||
| 3 | Intra-Golgi traffic |
Pathways by source for GOLIM4 Gene
4 Reactome pathways for GOLIM4 Gene
Interacting Proteins for GOLIM4 Gene
No data available for SIGNOR curated interactions for GOLIM4 Gene
Transcripts for GOLIM4 Gene
mRNA/cDNA for GOLIM4 Gene
- (5) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (113) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GOLIM4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GOLIM4
-
Santa Cruz Biotechnology (SCBT) CRISPR for GOLIM4
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miRNA Products
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Inhibitory RNA Products
- Origene RNAi, shRNA, mouse_rna, and siRNA products in human, mouse, rat for GOLIM4
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-
ViGene Biosciences ready-to-package AAV shRNAs for GOLIM4 gene
Clone Products
- OriGene clones in human for GOLIM4
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Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||
| SP2: | - |
Expression for GOLIM4 Gene
This gene is overexpressed in Lavage (16.7), Vitreous humor (14.1), and Pancreas (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GOLIM4 Gene
SOURCE GeneReport for Unigene cluster for GOLIM4 Gene Hs.143600
Primer Products
-
OriGene qPCR primer pairs for GOLIM4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GOLIM4 Gene
Orthologs for GOLIM4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | GOLIM4 35 |
|
||
| GOLIM4 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | GOLIM4 35 |
|
||
| GOLIM4 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Golim4 35 |
|
||
| Golim4 16 |
|
||||
| Golim4 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | GOLIM4 35 |
|
||
| GOLIM4 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Golim4 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GOLIM4 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GOLIM4 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GOLIM4 35 |
|
||
| GOLIM4 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | GOLIM4 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | golim4 35 |
|
||
| Str.10991 35 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.14113 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | golim4a 35 |
|
||
| wufc54e03 35 |
|
||||
| golim4a 36 |
|
OneToMany | |||
| golim4b 36 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToOne |
- Species with no ortholog for GOLIM4:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GOLIM4 Gene
No data available for Paralogs for GOLIM4 Gene
Variants for GOLIM4 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036611 | A breast cancer sample | ||||
| rs11065 | -- | 168,095,574(+) | CCGGC(A/T)GCCCT | utr-variant-5-prime | |
| rs1851395 | -- | 168,068,842(+) | ATTTT(A/T)TTTTT | intron-variant | |
| rs1851396 | -- | 168,068,855(+) | TTTTG(A/G)GACAG | intron-variant | |
| rs1879814 | -- | 168,063,594(+) | AATAT(G/T)TTAAT | intron-variant |
Residual Variation Intolerance Score:
29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.71;
73.18% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GOLIM4 Gene
Disorders for GOLIM4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| nasopharynx carcinoma |
|
|
| pharynx cancer |
|
|
Search GOLIM4 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for GOLIM4
No data available for UniProtKB/Swiss-Prot and Genatlas for GOLIM4 Gene
Publications for GOLIM4 Gene
- Sequence and overexpression of GPP130/GIMPc: evidence for saturable pH-sensitive targeting of a type II early Golgi membrane protein. (PMID: 9201717) Linstedt A.D. … Hauri H.-P. (Mol. Biol. Cell 1997) 2 3 4 23 67
- Both post-Golgi and intra-Golgi cycling affect the distribution of the Golgi phosphoprotein GPP130. (PMID: 17605763) Starr T. … Storrie B. (Traffic 2007) 3 23
- The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. (PMID: 15004235) Oka T. … Krieger M. (Mol. Biol. Cell 2004) 2 3
- Lumenal endosomal and Golgi-retrieval determinants involved in pH- sensitive targeting of an early Golgi protein. (PMID: 11598199) Bachert C. … Linstedt A.D. (Mol. Biol. Cell 2001) 3 23
- Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
Products for GOLIM4 Gene
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- antibodies-online Antibodies for GOLIM4: See all 21
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Sources for GOLIM4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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- (18) KEGG
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
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- (64) Nature
- (65) NCBI
- (66) OriGene
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- (69) Salk
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- (74) Tocris
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- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
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- (89) GeneGo (Thomson Reuters)
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- (107) COMPARTMENTS
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- (113) antibodies-online
- (114) CYP
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