Aliases for GOLIM4 Gene
Aliases for GOLIM4 Gene
External Ids for GOLIM4 Gene
- HGNC: 15448
- Entrez Gene: 27333
- Ensembl: ENSG00000173905
- OMIM: 606805
- UniProtKB: O00461
Previous HGNC Symbols for GOLIM4 Gene
- GOLPH4
Previous GeneCards Identifiers for GOLIM4 Gene
- GC03M169210
- GC03M167727
- GC03M165097
Summaries for GOLIM4 Gene
-
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi-resident protein. It may process proteins synthesized in the rough endoplasmic reticulum and assist in the transport of protein cargo through the Golgi apparatus. [provided by RefSeq, Jul 2008]
GeneCards Summary for GOLIM4 Gene
GOLIM4 (Golgi Integral Membrane Protein 4) is a Protein Coding gene. Diseases associated with GOLIM4 include Myasthenic Syndrome, Congenital, 5 and Congenital Myasthenic Syndrome. Among its related pathways are Vesicle-mediated transport and Intra-Golgi traffic.
UniProtKB/Swiss-Prot for GOLIM4 Gene
-
Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.
Additional gene information for GOLIM4 Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLIM4 Gene
Genomics for GOLIM4 Gene
GeneHancer (GH) Regulatory Elements for GOLIM4 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH03I168090 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 550.8 | +1.7 | 1748 | 6.6 | CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 | GOLIM4 HMGN1P8 SERPINI2 HMGN2P26 | |
GH03I168047 | Enhancer | 0.8 | ENCODE | 13 | +48.6 | 48587 | 0.2 | PKNOX1 RB1 ARID4B ZNF2 ZSCAN9 RAD21 RFX5 YY1 ARID2 ZNF366 | GOLIM4 HMGN2P26 | |
GH03I168051 | Enhancer | 0.7 | FANTOM5 | 13 | +44.3 | 44261 | 0.2 | BATF IRF4 ZNF366 NFATC1 ATF7 ETV6 IKZF2 RUNX3 ZNF362 ZBED1 | GOLIM4 HMGN2P26 | |
GH03I168049 | Enhancer | 0.6 | Ensembl | 13 | +46.7 | 46674 | 0.6 | ZEB2 YY1 ZFHX2 JUND PRDM6 GATA3 ZBTB48 ZNF629 PRDM4 ZBTB17 | GOLIM4 HMGN2P26 | |
GH03I168024 | Enhancer | 0.8 | Ensembl ENCODE | 6.5 | +71.1 | 71116 | 1.7 | JUND POLR2A JUN MAX FOS MYC MAFK RUNX3 | GOLIM4 HMGN2P26 |
- Top Transcription factor binding sites by QIAGEN in the GOLIM4 gene promoter:
Regulatory Element Products
Genomic Locations for GOLIM4 Gene
- chr3:168,008,669-168,095,975
- (GRCh38/hg38)
- Size:
- 87,307 bases
- Orientation:
- Minus strand
- chr3:167,726,465-167,813,763
- (GRCh37/hg19)
Genomic View for GOLIM4 Gene
- Cytogenetic band:
-
- 3q26.2 by Ensembl
- 3q26.2 by Entrez Gene
- 3q26.2 by HGNC


RefSeq DNA sequence for GOLIM4 Gene
Proteins for GOLIM4 Gene
-
Protein details for GOLIM4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00461-GOLI4_HUMAN
- Recommended name:
- Golgi integral membrane protein 4
- Protein Accession:
- O00461
Protein attributes for GOLIM4 Gene
- Size:
- 696 amino acids
- Molecular mass:
- 81880 Da
- Quaternary structure:
- No Data Available
Protein Expression for GOLIM4 Gene
Post-translational modifications for GOLIM4 Gene
- N-glycosylated; N-glycans are probably of the complex type and modified by sialic acid residues.
- O-glycosylated; modified by sialic acid residues.
- Phosphorylated probably by c-AMP-dependent kinases in its lumenal part.
- Glycosylation at isoforms=194, isoforms=216, posLast=229229, isoforms=257, isoforms=270, isoforms=276, posLast=283283, posLast=302302, posLast=308308, posLast=396396, and isoforms=405
Other Protein References for GOLIM4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
Abcam antibodies for GOLIM4
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Assay Products
No data available for DME Specific Peptides for GOLIM4 Gene
Domains & Families for GOLIM4 Gene
Gene Families for GOLIM4 Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for GOLIM4 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for GOLIM4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O00461- Family:
-
- Belongs to the GOLIM4 family.
Function for GOLIM4 Gene
Molecular function for GOLIM4 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.
Phenotypes From GWAS Catalog for GOLIM4 Gene
Phenotypes for GOLIM4 Gene
- GenomeRNAi human phenotypes for GOLIM4:
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-
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miRNA for GOLIM4 Gene
- miRTarBase miRNAs that target GOLIM4
-
- hsa-mir-149-5p (MIRT045671)
- hsa-mir-148a-3p (MIRT048034)
- hsa-mir-92a-3p (MIRT049004)
- hsa-mir-30e-3p (MIRT526475)
- hsa-mir-30d-3p (MIRT526476)
- hsa-mir-30a-3p (MIRT526477)
- hsa-mir-222-5p (MIRT526478)
- hsa-mir-556-3p (MIRT526479)
- hsa-mir-16-1-3p (MIRT526480)
- hsa-mir-487b-5p (MIRT548023)
- hsa-mir-487a-5p (MIRT548024)
- hsa-mir-4658 (MIRT548025)
- hsa-mir-6790-5p (MIRT548026)
- hsa-mir-4477a (MIRT548027)
- hsa-mir-1273g-5p (MIRT548028)
- hsa-mir-203a-5p (MIRT548029)
- hsa-mir-3659 (MIRT548030)
- hsa-mir-574-5p (MIRT548031)
- hsa-mir-4282 (MIRT548032)
- hsa-mir-3163 (MIRT548033)
- hsa-mir-8055 (MIRT548034)
- hsa-mir-105-3p (MIRT548035)
- hsa-mir-4468 (MIRT548036)
- hsa-mir-6806-5p (MIRT548037)
- hsa-mir-936 (MIRT548038)
- hsa-mir-5000-5p (MIRT548039)
- hsa-mir-449c-5p (MIRT548040)
- hsa-mir-34b-5p (MIRT548041)
- hsa-mir-2682-5p (MIRT548042)
- hsa-mir-940 (MIRT548043)
- hsa-mir-6808-5p (MIRT548044)
- hsa-mir-6893-5p (MIRT548045)
- hsa-mir-6511a-5p (MIRT548046)
- hsa-mir-1910-3p (MIRT548047)
- hsa-mir-646 (MIRT548048)
- hsa-mir-186-5p (MIRT548049)
- hsa-mir-3129-5p (MIRT548050)
- hsa-mir-199a-3p (MIRT548051)
- hsa-mir-199b-3p (MIRT548052)
- hsa-mir-6881-3p (MIRT643149)
- hsa-mir-6780a-3p (MIRT643150)
- hsa-mir-7111-3p (MIRT643151)
- hsa-mir-302a-5p (MIRT643152)
- hsa-mir-877-3p (MIRT643153)
- hsa-mir-10a-3p (MIRT643154)
miRNA Products
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLIM4 Gene
Localization for GOLIM4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GOLIM4 Gene
- Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor. Note=Localizes to cis and medial Golgi cisternae. Probably cycles between early Golgi and distal compartments like endosome.
- Golgi apparatus (4)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | TAS | -- |
GO:0005768 | endosome | IEA | -- |
GO:0005794 | Golgi apparatus | IDA | -- |
GO:0005796 | Golgi lumen | TAS | 9201717 |
GO:0005801 | cis-Golgi network | TAS | 9201717 |
Pathways & Interactions for GOLIM4 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Vesicle-mediated transport | ||
2 | Golgi-to-ER retrograde transport | ||
3 | Intra-Golgi traffic |
Pathways by source for GOLIM4 Gene
4 Reactome pathways for GOLIM4 Gene
Interacting Proteins for GOLIM4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006810 | transport | IEA | -- |
No data available for SIGNOR curated interactions for GOLIM4 Gene
Transcripts for GOLIM4 Gene
mRNA/cDNA for GOLIM4 Gene
- (5) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (113) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GOLIM4 Gene
CRISPR Products
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-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available GOLIM4 gene related products
- orf clones - Search results for available GOLIM4 gene related products
- Applied Biological Materials Clones for GOLIM4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||
SP2: | - |
Expression for GOLIM4 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GOLIM4 Gene
NURSA nuclear receptor signaling pathways regulating expression of GOLIM4 Gene:
GOLIM4SOURCE GeneReport for Unigene cluster for GOLIM4 Gene:
Hs.143600Evidence on tissue expression from TISSUES for GOLIM4 Gene
- Intestine(4.4)
- Liver(4.4)
- Heart(2.3)
- Nervous system(2.1)
- Kidney(2)
- Spleen(2)
Primer Products
-
OriGene qPCR primer pairs for GOLIM4
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLIM4 Gene
Orthologs for GOLIM4 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | GOLIM4 34 33 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | GOLIM4 34 33 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | GOLIM4 34 33 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Golim4 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Golim4 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | GOLIM4 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | GOLIM4 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | GOLIM4 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | GOLIM4 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | golim4 33 |
|
||
Str.10991 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.14113 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | golim4a 33 34 |
|
||
golim4b 34 |
|
OneToMany | |||
wufc54e03 33 |
|
||||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for GOLIM4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GOLIM4 Gene
No data available for Paralogs for GOLIM4 Gene
Variants for GOLIM4 Gene
SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
VAR_036611 | A breast cancer sample | p.Ala312Val | |||
rs1000055971 | -- | 168,023,153(-) | T/C | intron_variant | |
rs1000062286 | -- | 168,033,485(-) | T/C | intron_variant | |
rs1000142322 | -- | 168,048,166(-) | C/T | intron_variant | |
rs1000156834 | -- | 168,053,087(-) | C/T | intron_variant |
Additional Variant Information for GOLIM4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GOLIM4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLIM4 Gene
Disorders for GOLIM4 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
myasthenic syndrome, congenital, 5 |
|
|
congenital myasthenic syndrome |
|
|
Additional Disease Information for GOLIM4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for GOLIM4 Gene
Publications for GOLIM4 Gene
- Sequence and overexpression of GPP130/GIMPc: evidence for saturable pH-sensitive targeting of a type II early Golgi membrane protein. (PMID: 9201717) Linstedt AD … Hauri HP (Molecular biology of the cell 1997) 2 3 4 22 58
- Lumenal endosomal and Golgi-retrieval determinants involved in pH-sensitive targeting of an early Golgi protein. (PMID: 11598199) Bachert C … Linstedt AD (Molecular biology of the cell 2001) 3 4 22 58
- Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 44 58
- Both post-Golgi and intra-Golgi cycling affect the distribution of the Golgi phosphoprotein GPP130. (PMID: 17605763) Starr T … Storrie B (Traffic (Copenhagen, Denmark) 2007) 3 22 58
- The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. (PMID: 15004235) Oka T … Krieger M (Molecular biology of the cell 2004) 2 3 58
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 34 available GOLIM4 Antibodies ranked by validation data
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Sources for GOLIM4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew