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Aliases for GOLIM4 Gene

Aliases for GOLIM4 Gene

  • Golgi Integral Membrane Protein 4 2 3 5
  • Golgi Phosphoprotein 4 2 3 4
  • Golgi-Localized Phosphoprotein Of 130 KDa 3 4
  • Golgi Integral Membrane Protein, Cis 3 4
  • Golgi Phosphoprotein Of 130 KDa 3 4
  • GOLPH4 3 4
  • GPP130 3 4
  • GIMPC 3 4
  • Cis Golgi-Localized Calcium-Binding Protein 3
  • 130 KDa Golgi-Localized Phosphoprotein 3
  • Type II Golgi Membrane Protein 3
  • P138 3

External Ids for GOLIM4 Gene

Previous HGNC Symbols for GOLIM4 Gene

  • GOLPH4

Previous GeneCards Identifiers for GOLIM4 Gene

  • GC03M169210
  • GC03M167727
  • GC03M165097

Summaries for GOLIM4 Gene

Entrez Gene Summary for GOLIM4 Gene

  • The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi-resident protein. It may process proteins synthesized in the rough endoplasmic reticulum and assist in the transport of protein cargo through the Golgi apparatus. [provided by RefSeq, Jul 2008]

GeneCards Summary for GOLIM4 Gene

GOLIM4 (Golgi Integral Membrane Protein 4) is a Protein Coding gene. Diseases associated with GOLIM4 include Nasopharynx Carcinoma and Pharynx Cancer. Among its related pathways are Golgi-to-ER retrograde transport and Vesicle-mediated transport.

UniProtKB/Swiss-Prot for GOLIM4 Gene

  • Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLIM4 Gene

Genomics for GOLIM4 Gene

Regulatory Elements for GOLIM4 Gene

Enhancers for GOLIM4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GOLIM4 on UCSC Golden Path with GeneCards custom track

Promoters for GOLIM4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GOLIM4 on UCSC Golden Path with GeneCards custom track

Genomic Location for GOLIM4 Gene

168,008,669 bp from pter
168,095,975 bp from pter
87,307 bases
Minus strand

Genomic View for GOLIM4 Gene

Genes around GOLIM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLIM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLIM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLIM4 Gene

Proteins for GOLIM4 Gene

  • Protein details for GOLIM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Golgi integral membrane protein 4
    Protein Accession:

    Protein attributes for GOLIM4 Gene

    696 amino acids
    Molecular mass:
    81880 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GOLIM4 Gene

Proteomics data for GOLIM4 Gene at MOPED

Post-translational modifications for GOLIM4 Gene

  • N-glycosylated; N-glycans are probably of the complex type and modified by sialic acid residues.
  • O-glycosylated; modified by sialic acid residues.
  • Phosphorylated probably by c-AMP-dependent kinases in its lumenal part.
  • Glycosylation at Thr 194, Thr 216, Thr 229, Asn 257, Thr 270, Thr 276, Ser 283, Thr 302, Thr 308, Ser 396, and Ser 405
  • Modification sites at PhosphoSitePlus

Other Protein References for GOLIM4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GOLIM4 Gene

Domains & Families for GOLIM4 Gene

Protein Domains for GOLIM4 Gene


Suggested Antigen Peptide Sequences for GOLIM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GOLIM4 family.
  • Belongs to the GOLIM4 family.
genes like me logo Genes that share domains with GOLIM4: view

No data available for Gene Families for GOLIM4 Gene

Function for GOLIM4 Gene

Molecular function for GOLIM4 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.
genes like me logo Genes that share phenotypes with GOLIM4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLIM4 Gene

Localization for GOLIM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLIM4 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor. Note=Localizes to cis and medial Golgi cisternae. Probably cycles between early Golgi and distal compartments like endosome.

Subcellular locations from

Jensen Localization Image for GOLIM4 Gene COMPARTMENTS Subcellular localization image for GOLIM4 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
endosome 4
extracellular 3
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for GOLIM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005654 nucleoplasm IDA --
GO:0005796 Golgi lumen TAS 9201717
GO:0005801 cis-Golgi network TAS 9201717
GO:0010008 endosome membrane IEA --
genes like me logo Genes that share ontologies with GOLIM4: view

Pathways & Interactions for GOLIM4 Gene

genes like me logo Genes that share pathways with GOLIM4: view

Pathways by source for GOLIM4 Gene

Interacting Proteins for GOLIM4 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000417354 O00461-GOLI4_HUMAN for GOLIM4 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for GOLIM4 Gene


No data available for SIGNOR curated interactions for GOLIM4 Gene

Drugs & Compounds for GOLIM4 Gene

No Compound Related Data Available

Transcripts for GOLIM4 Gene

Unigene Clusters for GOLIM4 Gene

Golgi integral membrane protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GOLIM4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP2: -

Relevant External Links for GOLIM4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GOLIM4 Gene

mRNA expression in normal human tissues for GOLIM4 Gene

Protein differential expression in normal tissues from HIPED for GOLIM4 Gene

This gene is overexpressed in Lavage (16.7), Vitreous humor (14.1), and Pancreas (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GOLIM4 Gene

SOURCE GeneReport for Unigene cluster for GOLIM4 Gene Hs.143600

genes like me logo Genes that share expression patterns with GOLIM4: view

Protein tissue co-expression partners for GOLIM4 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GOLIM4 Gene

Orthologs for GOLIM4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GOLIM4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GOLIM4 35
  • 87.32 (n)
  • 85.73 (a)
  • 85 (a)
(Canis familiaris)
Mammalia GOLIM4 35
  • 86.88 (n)
  • 86.2 (a)
  • 85 (a)
(Mus musculus)
Mammalia Golim4 35
  • 84.05 (n)
  • 82.98 (a)
Golim4 16
Golim4 36
  • 82 (a)
(Pan troglodytes)
Mammalia GOLIM4 35
  • 99.33 (n)
  • 98.71 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Golim4 35
  • 82.89 (n)
  • 82.89 (a)
(Monodelphis domestica)
Mammalia GOLIM4 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia GOLIM4 36
  • 70 (a)
(Gallus gallus)
Aves GOLIM4 35
  • 71.2 (n)
  • 72.08 (a)
  • 61 (a)
(Anolis carolinensis)
Reptilia GOLIM4 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia golim4 35
  • 65.54 (n)
  • 62.17 (a)
Str.10991 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14113 35
(Danio rerio)
Actinopterygii golim4a 35
  • 62.82 (n)
  • 57.77 (a)
wufc54e03 35
golim4a 36
  • 47 (a)
golim4b 36
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
Species with no ortholog for GOLIM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GOLIM4 Gene

Gene Tree for GOLIM4 (if available)
Gene Tree for GOLIM4 (if available)

Paralogs for GOLIM4 Gene

No data available for Paralogs for GOLIM4 Gene

Variants for GOLIM4 Gene

Sequence variations from dbSNP and Humsavar for GOLIM4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_036611 A breast cancer sample
rs11065 -- 168,095,574(+) CCGGC(A/T)GCCCT utr-variant-5-prime
rs1851395 -- 168,068,842(+) ATTTT(A/T)TTTTT intron-variant
rs1851396 -- 168,068,855(+) TTTTG(A/G)GACAG intron-variant
rs1879814 -- 168,063,594(+) AATAT(G/T)TTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GOLIM4 Gene

Variant ID Type Subtype PubMed ID
nsv829787 CNV Gain 17160897

Variation tolerance for GOLIM4 Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.71; 73.18% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GOLIM4 Gene

Disorders for GOLIM4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GOLIM4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nasopharynx carcinoma
  • nasopharyngeal carcinoma
pharynx cancer
  • pharyngeal cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GOLIM4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GOLIM4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GOLIM4 Gene

Publications for GOLIM4 Gene

  1. Sequence and overexpression of GPP130/GIMPc: evidence for saturable pH-sensitive targeting of a type II early Golgi membrane protein. (PMID: 9201717) Linstedt A.D. … Hauri H.-P. (Mol. Biol. Cell 1997) 2 3 4 23 67
  2. Both post-Golgi and intra-Golgi cycling affect the distribution of the Golgi phosphoprotein GPP130. (PMID: 17605763) Starr T. … Storrie B. (Traffic 2007) 3 23
  3. The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. (PMID: 15004235) Oka T. … Krieger M. (Mol. Biol. Cell 2004) 2 3
  4. Lumenal endosomal and Golgi-retrieval determinants involved in pH- sensitive targeting of an early Golgi protein. (PMID: 11598199) Bachert C. … Linstedt A.D. (Mol. Biol. Cell 2001) 3 23
  5. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3

Products for GOLIM4 Gene

Sources for GOLIM4 Gene