Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GOLGB1 Gene

Aliases for GOLGB1 Gene

  • Golgin B1 2 3 5
  • Macrogolgin 2 3 4
  • Golgi Autoantigen, Golgin Subfamily B, Macrogolgin (With Transmembrane Signal), 1 2 3
  • Golgin B1, Golgi Integral Membrane Protein 2 3
  • 372 KDa Golgi Complex-Associated Protein 3 4
  • Golgi Integral Membrane Protein 1 2 3
  • Giantin 3 4
  • GCP372 3 4
  • GOLIM1 3
  • GCP 3

External Ids for GOLGB1 Gene

Previous GeneCards Identifiers for GOLGB1 Gene

  • GC03P118042
  • GC03M121023
  • GC03M122663
  • GC03M122703
  • GC03M122681
  • GC03M122865
  • GC03M121382
  • GC03M118756

Summaries for GOLGB1 Gene

GeneCards Summary for GOLGB1 Gene

GOLGB1 (Golgin B1) is a Protein Coding gene. Diseases associated with GOLGB1 include Blue Cone Monochromacy and Pedophilia. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. GO annotations related to this gene include poly(A) RNA binding and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for GOLGB1 Gene

  • May participate in forming intercisternal cross-bridges of the Golgi complex.

Gene Wiki entry for GOLGB1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLGB1 Gene

Genomics for GOLGB1 Gene

Regulatory Elements for GOLGB1 Gene

Enhancers for GOLGB1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GOLGB1 on UCSC Golden Path with GeneCards custom track

Promoters for GOLGB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GOLGB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GOLGB1 Gene

Chromosome:
3
Start:
121,663,199 bp from pter
End:
121,750,811 bp from pter
Size:
87,613 bases
Orientation:
Minus strand

Genomic View for GOLGB1 Gene

Genes around GOLGB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLGB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLGB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGB1 Gene

Proteins for GOLGB1 Gene

  • Protein details for GOLGB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14789-GOGB1_HUMAN
    Recommended name:
    Golgin subfamily B member 1
    Protein Accession:
    Q14789
    Secondary Accessions:
    • B2ZZ91
    • D3DN92
    • E7EP74
    • F1T0J2
    • Q14398

    Protein attributes for GOLGB1 Gene

    Size:
    3259 amino acids
    Molecular mass:
    376019 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with PLK3.
    Miscellaneous:
    • Antigen in chronic rheumatoid arthritis and in the autoimmune disease Sjoegren syndrome.

    Alternative splice isoforms for GOLGB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOLGB1 Gene

Proteomics data for GOLGB1 Gene at MOPED

Post-translational modifications for GOLGB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for GOLGB1 (GOLGB1/Giantin)

No data available for DME Specific Peptides for GOLGB1 Gene

Domains & Families for GOLGB1 Gene

Protein Domains for GOLGB1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GOLGB1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GOLGB1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GOLGB1 Gene

Function for GOLGB1 Gene

Molecular function for GOLGB1 Gene

UniProtKB/Swiss-Prot Function:
May participate in forming intercisternal cross-bridges of the Golgi complex.

Gene Ontology (GO) - Molecular Function for GOLGB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14980500
genes like me logo Genes that share ontologies with GOLGB1: view
genes like me logo Genes that share phenotypes with GOLGB1: view

Animal Model Products

miRNA for GOLGB1 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLGB1 Gene

Localization for GOLGB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLGB1 Gene

Golgi apparatus membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GOLGB1 Gene COMPARTMENTS Subcellular localization image for GOLGB1 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 2
nucleus 2
peroxisome 2
cytoskeleton 1
cytosol 1
endosome 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GOLGB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0005795 Golgi stack TAS 7691276
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GOLGB1: view

Pathways & Interactions for GOLGB1 Gene

genes like me logo Genes that share pathways with GOLGB1: view

Gene Ontology (GO) - Biological Process for GOLGB1 Gene

None

No data available for SIGNOR curated interactions for GOLGB1 Gene

Drugs & Compounds for GOLGB1 Gene

(1) Drugs for GOLGB1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for GOLGB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GOLGB1: view

Transcripts for GOLGB1 Gene

Unigene Clusters for GOLGB1 Gene

Golgin B1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGB1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^
SP1: - - - - -
SP2: - - -
SP3: - - - - - -
SP4: -
SP5:
SP6:

ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for GOLGB1 Gene

GeneLoc Exon Structure for
GOLGB1
ECgene alternative splicing isoforms for
GOLGB1

Expression for GOLGB1 Gene

mRNA expression in normal human tissues for GOLGB1 Gene

Protein differential expression in normal tissues from HIPED for GOLGB1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (12.0), Peripheral blood mononuclear cells (11.5), and Salivary gland (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GOLGB1 Gene



SOURCE GeneReport for Unigene cluster for GOLGB1 Gene Hs.213389

genes like me logo Genes that share expression patterns with GOLGB1: view

Protein tissue co-expression partners for GOLGB1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GOLGB1 Gene

Orthologs for GOLGB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GOLGB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GOLGB1 35
  • 87.75 (n)
  • 85.06 (a)
GOLGB1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GOLGB1 35
  • 89.11 (n)
  • 86.49 (a)
GOLGB1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Golgb1 35
  • 79.81 (n)
  • 76.24 (a)
Golgb1 16
Golgb1 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GOLGB1 35
  • 99.52 (n)
  • 99.05 (a)
GOLGB1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Golgb1 35
  • 79.19 (n)
  • 75.46 (a)
oppossum
(Monodelphis domestica)
Mammalia GOLGB1 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GOLGB1 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves GOLGB1 35
  • 61.41 (n)
  • 52.43 (a)
GOLGB1 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GOLGB1 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6338 35
zebrafish
(Danio rerio)
Actinopterygii golgb1 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C02F12.7 37
  • 22 (a)
Species with no ortholog for GOLGB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GOLGB1 Gene

ENSEMBL:
Gene Tree for GOLGB1 (if available)
TreeFam:
Gene Tree for GOLGB1 (if available)

Paralogs for GOLGB1 Gene

No data available for Paralogs for GOLGB1 Gene

Variants for GOLGB1 Gene

Sequence variations from dbSNP and Humsavar for GOLGB1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs3732407 - 121,697,776(+) TCTCA(C/G)TCATA nc-transcript-variant, reference, missense
rs3732410 - 121,696,873(-) TGACT(A/G)TAATC nc-transcript-variant, reference, missense
rs33988592 - 121,696,763(+) GCTTG(A/C/G)GAGTT nc-transcript-variant, reference, missense
rs35674179 - 121,695,370(-) AGAGT(G/T)TATGG nc-transcript-variant, reference, missense
rs1127412 - 121,695,214(-) AGAAG(A/G)TAATG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GOLGB1 Gene

Variant ID Type Subtype PubMed ID
nsv829703 CNV Loss 17160897
nsv516233 CNV Gain+Loss 19592680
nsv877383 CNV Loss 21882294

Variation tolerance for GOLGB1 Gene

Residual Variation Intolerance Score: 43.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.98; 96.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GOLGB1 Gene

Human Gene Mutation Database (HGMD)
GOLGB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLGB1 Gene

Disorders for GOLGB1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for GOLGB1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
blue cone monochromacy
  • blue cone monochromatism
pedophilia
  • paedophilia
gastric dilatation
  • stomach dilatation
gastrointestinal lymphoma
paraphilia disorder
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GOLGB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GOLGB1
genes like me logo Genes that share disorders with GOLGB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GOLGB1 Gene

Publications for GOLGB1 Gene

  1. Giantin, a novel conserved Golgi membrane protein containing a cytoplasmic domain of at least 350 kDa. (PMID: 7691276) Linstedt A.D. … Hauri H.P. (Mol. Biol. Cell 1993) 2 3 23 67
  2. The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. (PMID: 15004235) Oka T. … Krieger M. (Mol. Biol. Cell 2004) 2 3 23
  3. Polo-like kinase 3 is Golgi localized and involved in regulating Golgi fragmentation during the cell cycle. (PMID: 14980500) Ruan Q. … Dai W. (Exp. Cell Res. 2004) 3 23
  4. Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115. (PMID: 11927603) Shorter J. … Warren G. (J. Cell Biol. 2002) 3 23
  5. CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin. (PMID: 12429822) Gillingham A.K. … Munro S. (Mol. Biol. Cell 2002) 3 23

Products for GOLGB1 Gene

Sources for GOLGB1 Gene

Content