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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GOLGB1 Gene

protein-coding   GIFtS: 49
GCID: GC03M121382

golgin B1

(Previous names: golgi autoantigen, golgin subfamily b, macrogolgin (with...)
 Explore 7 diseases affiliated with
GOLGB1 via our new
 Human Malady Compendium 
Biological research products
for GOLGB1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Golgin B11 2     372 KDa Golgi Complex-Associated Protein2 3
GCP3721 2 3 5     Golgi Integral Membrane Protein 12
GCP1 2     Golgin Subfamily B Member 12
GOLIM11 2     Macrogolgin3
Giantin3     Giantin3
Golgi Autoantigen, Golgin Subfamily B, Macrogolgin (With Transmembrane Signal),
11 2
     Macrogolgin3
Golgin B1, Golgi Integral Membrane Protein1 2     

External Ids:    HGNC: 44291   Entrez Gene: 28042   Ensembl: ENSG000001732307   OMIM: 6025005   UniProtKB: Q147893   

Export aliases for GOLGB1 gene to outside databases

Previous GC identifers: GC03P118042 GC03M121023 GC03M122663 GC03M122703 GC03M122681 GC03M122865 GC03M118756


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: GOGB1_HUMAN, Q14789
Function: May participate in forming intercisternal cross-bridges of the Golgi complex

Gene Wiki entry for GOLGB1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GOLGB1 gene promoter:
         Nkx2-5   NF-E2 p45   GATA-1   CRE-BP1   S8   NF-E2   NF-Y   CBF(2)   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGOLGB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GOLGB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GOLGB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13   Ensembl cytogenetic band:  3q13.33   HGNC cytogenetic band: 3q13

GOLGB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GOLGB1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M121382:  view genomic region     (about GC identifiers)

Start:
121,382,046 bp from pter      End:
121,468,602 bp from pter
Size:
86,557 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GOGB1_HUMAN, Q14789 (See protein sequence)
Recommended Name: Golgin subfamily B member 1  
Size: 3259 amino acids; 376019 Da
Subunit: Homodimer; disulfide-linked. Interacts with PLK3
Subcellular location: Golgi apparatus membrane; Single-pass type I membrane protein
Miscellaneous: Antigen in chronic rheumatoid arthritis and in the autoimmune disease Sjoegren syndrome
Secondary accessions: B2ZZ91 D3DN92 E7EP74 Q14398
Alternative splicing: 2 isoforms:  Q14789-1   Q14789-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GOLGB1: NX_Q14789

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14789

  • GOLGB1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001243415.1  NP_001243416.1  NP_001243417.1  NP_004478.3  

    ENSEMBL proteins: 
     ENSP00000341848   ENSP00000377275   ENSP00000419519   ENSP00000420027   ENSP00000418231  
     ENSP00000417767   ENSP00000417695  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for GOLGB1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IDA15308636
    GO:0005794Golgi apparatus IDA--
    GO:0005795Golgi stack TAS7691276
    GO:0016021integral to membrane IEA--


    GOLGB1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GOLGB1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026202 GOLGB1

    Graphical View of Domain Structure for InterPro Entry Q14789

    ProtoNet protein and cluster: Q14789


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: GOGB1_HUMAN, Q14789
    Function: May participate in forming intercisternal cross-bridges of the Golgi complex

    miRNA
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    hsa-miR-185* hsa-miR-4251 hsa-miR-539 hsa-miR-2278 hsa-miR-3647-3p hsa-miR-942 hsa-miR-873 hsa-miR-582-5p
    SwitchGear 3'UTR luciferase reporter plasmidGOLGB1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOLGB1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16169070


    GOLGB1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for GOLGB1:
     Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GOLGB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/551 Interacting proteins for GOLGB1 (Q147891, 2, 3 ENSP000003418484) via UniProtKB, MINT, STRING, and/or I2D (see all 551)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PFN2P350801, 2, 3EBI-709973,EBI-473138 MINT-64179 I2D: score=5 
    CAV2P516362, 3, ENSP000002226934MINT-64180 I2D: score=4 STRING: ENSP00000222693
    USO1O607632, 3, ENSP000004116984MINT-7947479 I2D: score=4 STRING: ENSP00000411698
    SLC2A3P111692, 3, ENSP000000751204MINT-64178 I2D: score=3 STRING: ENSP00000075120
    GORASP2Q9H8Y82, 3, ENSP000002341604MINT-7897551 I2D: score=1 STRING: ENSP00000234160
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007030Golgi organization TAS7691276


    GOLGB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GOLGB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GOLGB1
    2 Novoseek chemical compound relationships for GOLGB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 6-phosphate 54.3 2 9004032 (1), 15353600 (1)
    sucrose 4.33 1 7691276 (1)

    Search CenterWatch for drugs/clinical trials and news about GOLGB1 / GOGB1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GOLGB1 gene (4 alternative transcripts): 
    NM_001256486.1  NM_001256487.1  NM_001256488.1  NM_004487.4  

    Unigene Cluster for GOLGB1:

    Golgin B1
    Hs.213389  [show with all ESTs]
    Unigene Representative Sequence: NM_001256487
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340645(uc003eei.4 uc003eej.4 uc021xcy.1 uc010hrd.1)
    ENST00000393667(uc010hrc.3) ENST00000482512(uc011bjm.1) ENST00000491690
    ENST00000494517 ENST00000489400 ENST00000472829 ENST00000472475

    miRNA
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    hsa-miR-185* hsa-miR-4251 hsa-miR-539 hsa-miR-2278 hsa-miR-3647-3p hsa-miR-942 hsa-miR-873 hsa-miR-582-5p
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB371588.1 AB593126.1 AK094551.1 AK296903.1 AK298986.1 AK300437.1 BC065301.1 BX537520.1 
    D25542.1 X75304.1 

    18 DOTS entries:

    DT.97801837  DT.75182818  DT.101981709  DT.101960532  DT.91876996  DT.95189443  DT.100791216  DT.86853401 
    DT.92452376  DT.95171462  DT.97811919  DT.95200249  DT.100730176  DT.100791214  DT.120866933  DT.95171451 
    DT.87017578  DT.95124601 

    24/430 AceView cDNA sequences (see all 430):

    BU676460 BU730231 BP376936 AI678495 CA450345 AA599281 AL704965 AK094551 
    AA947859 F06075 BM702798 BX096135 BM790776 AU141795 T29860 BX509873 
    BU177998 BQ644751 AL712084 AI348670 AW517882 N47489 CA444999 AI935485 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for GOLGB1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^
    SP1:                          -     -                 -                 -                                         -                                             
    SP2:                                -                 -                                                           -                                             
    SP3:                          -     -                 -                 -     -                                   -                                             
    SP4:                                                                                                              -                                             
    SP5:                                                                                                                                                            

    ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for GOLGB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GOLGB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCCTGCTCAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See GOLGB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GOLGB1

    SOURCE GeneReport for Unigene cluster: Hs.213389
        SABiosciences Custom PCR Arrays for GOLGB1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOLGB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GOLGB1 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves GOLGB11 golgin B1 60.97(n)
    51.44(a)
      426868  XM_424476.3  XP_424476.3 
    lizard
    (Anolis carolinensis)
    Reptilia GOLGB16
    --
    43(a)
    1 ↔ 1
    4(136708819-136741952)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.63382 Transcribed sequence with weak similarity to protein more 72.67(n)    AL956693.2 
    zebrafish
    (Danio rerio)
    Actinopterygii golgb11 golgi autoantigen, golgin subfamily b, macrogolgin more 45.68(n)
    32.13(a)
      566353  XM_001920290.3  XP_001920325.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta lva6
    lava lamp
    7(a)
    1 ↔ 1
    X(3849578-3858787)
    worm
    (Caenorhabditis elegans)
    Secernentea C02F12.73   -- 22(a)   X(3719662-3723865)   --


    ENSEMBL Gene Tree for GOLGB1 (if available)
    TreeFam Gene Tree for GOLGB1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GOLGB1 gene
    GOLGA42  GCC22  CEP2502  AKAP92  PCNT2  LOC7287632  CROCC2  EEA12  
    NUMA12  TRIP112  CENPF2  CNTRL2  

    GOLGB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1300 NCBI SNPs in GOLGB1 are shown (see all 1300    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1431554991,2
    --121381575(+) AAACTC/TGGTCT 5 -- us2k1 int10--------
    rs2006888861,2
    --121381611(+) AAAAC-/ATAATAAT 5 -- us2k1 int10--------
    rs1482700261,2
    --121381717(+) ACAAGA/GGTTCT 5 -- us2k1 int10--------
    rs1826147651,2
    --121381751(+) ATCAAC/TTTCAT 5 -- int1 us2k10--------
    rs1864757291,2
    --121381876(+) GGCCAG/TTGAGA 4 -- int10--------
    rs1418849101,2
    --121381976(+) AGCATA/GCAAAC 4 -- int10--------
    rs117194581,2
    C,F,A,H,--121382005(+) GTGCAC/TATATC 4 -- int128Minor allele frequency- T:0.16NS EA NA WA 3130
    rs1896723961,2
    --121382156(+) AGCCCA/GCTTGT 4 -- ut310--------
    rs1830260241,2
    --121382159(+) CCACTA/TGTCTT 4 -- ut310--------
    rs797804201,2
    F,--121382166(+) TCTTCT/CCTCTT 4 -- ut311Minor allele frequency- C:0.03EA 120

    HapMap Linkage Disequilibrium report for GOLGB1 (121382046 - 121468602 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for GOLGB1: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GOLGB1 for disorders           About GeneDecksing

    OMIM gene information: 602500    OMIM disorders: --

    7 diseases for GOLGB1:    About MalaCards
    tick-borne encephalitis    encephalitis    pulmonary hypertension    hematopoiesis
    hypertension    myopathy    arthritis


    Export disorders for GOLGB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GOLGB1 gene, integrated from 9 sources (see all 83):
    (articles sorted by number of sources associating them with GOLGB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Giantin, a novel conserved Golgi membrane protein containing a cytoplasmic domain of at least 350 kDa. (PubMed id 7691276)1, 3, 9 Linstedt A.D. and Hauri H.P. (1993)
    2. Macrogolgin -- a new 376 kD Golgi complex outer membrane protein as target of antibodies in patients with rheumatic diseases and HIV infections. (PubMed id 8198703)1, 2, 9 Seelig H.P....Renz M. (1994)
    3. Polo-like kinase 3 is Golgi localized and involved in regulating Golgi fragmentation during the cell cycle. (PubMed id 14980500)1, 2, 9 Ruan Q....Dai W. (2004)
    4. The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. (PubMed id 15004235)1, 3, 9 Oka T....Krieger M. (2004)
    5. Fine expression profiling of full-length transcripts using a size- unbiased cDNA library prepared with the vector-capping method. (PubMed id 18487259)1, 2 Oshikawa M.... Kato S. (2008)
    6. Molecular cloning and sequence analysis of a human 372-kDa protein localized in the Golgi complex. (PubMed id 7802676)1, 2 Sohda M.... Ikehara Y. (1994)
    7. Binding relationships of membrane tethering components. The giantin N terminus and the GM130 N terminus compete for binding to the p115 C terminus. (PubMed id 10744704)1, 9 Linstedt A.D....Sztul E. (2000)
    8. A role for giantin in docking COPI vesicles to Golgi membranes. (PubMed id 9490716)1, 9 Sonnichsen B....Warren G. (1998)
    9. Molecular genetic analyses of a 376-kilodalton Golgi complex membrane protein (giantin). (PubMed id 7511208)2, 9 Seelig H.P....Renz M. (1994)
    10. CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin. (PubMed id 12429822)1, 9 Gillingham A.K.... Munro S. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2804 HGNC: 4429 AceView: GOLGB1 Ensembl:ENSG00000173230 euGenes: HUgn2804
    ECgene: GOLGB1 H-InvDB: GOLGB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GOLGB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GOLGB1 gene:
    Search GeneIP for patents involving GOLGB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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