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Aliases for GOLGB1 Gene

Aliases for GOLGB1 Gene

  • Golgin B1 2 3
  • Macrogolgin 2 3 4
  • Golgi Autoantigen, Golgin Subfamily B, Macrogolgin (With Transmembrane Signal), 1 2 3
  • Golgin B1, Golgi Integral Membrane Protein 2 3
  • 372 KDa Golgi Complex-Associated Protein 3 4
  • Golgi Integral Membrane Protein 1 2 3
  • Giantin 3 4
  • GCP372 3 4
  • GOLIM1 3
  • GCP 3

External Ids for GOLGB1 Gene

Previous GeneCards Identifiers for GOLGB1 Gene

  • GC03P118042
  • GC03M121023
  • GC03M122663
  • GC03M122703
  • GC03M122681
  • GC03M122865
  • GC03M121382
  • GC03M118756

Summaries for GOLGB1 Gene

GeneCards Summary for GOLGB1 Gene

GOLGB1 (Golgin B1) is a Protein Coding gene. Diseases associated with GOLGB1 include pedophilia and gastric dilatation. GO annotations related to this gene include poly(A) RNA binding and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for GOLGB1 Gene

  • May participate in forming intercisternal cross-bridges of the Golgi complex

Gene Wiki entry for GOLGB1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLGB1 Gene

Genomics for GOLGB1 Gene

Regulatory Elements for GOLGB1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GOLGB1 Gene

121,663,199 bp from pter
121,750,811 bp from pter
87,613 bases
Minus strand

Genomic View for GOLGB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GOLGB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGB1 Gene

Proteins for GOLGB1 Gene

  • Protein details for GOLGB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Golgin subfamily B member 1
    Protein Accession:
    Secondary Accessions:
    • B2ZZ91
    • D3DN92
    • E7EP74
    • F1T0J2
    • Q14398

    Protein attributes for GOLGB1 Gene

    3259 amino acids
    Molecular mass:
    376019 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with PLK3.
    • Antigen in chronic rheumatoid arthritis and in the autoimmune disease Sjoegren syndrome

    Alternative splice isoforms for GOLGB1 Gene


neXtProt entry for GOLGB1 Gene

Proteomics data for GOLGB1 Gene at MOPED

Post-translational modifications for GOLGB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for GOLGB1 (GOLGB1/Giantin)

No data available for DME Specific Peptides for GOLGB1 Gene

Domains & Families for GOLGB1 Gene

Protein Domains for GOLGB1 Gene


Suggested Antigen Peptide Sequences for GOLGB1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GOLGB1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GOLGB1 Gene

Function for GOLGB1 Gene

Molecular function for GOLGB1 Gene

UniProtKB/Swiss-Prot Function:
May participate in forming intercisternal cross-bridges of the Golgi complex

Gene Ontology (GO) - Molecular Function for GOLGB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding --
GO:0005515 protein binding IPI 14980500
GO:0043565 sequence-specific DNA binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with GOLGB1: view
genes like me logo Genes that share phenotypes with GOLGB1: view

Animal Model Products

miRNA for GOLGB1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLGB1 Gene

Localization for GOLGB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLGB1 Gene

Golgi apparatus membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for GOLGB1 Gene COMPARTMENTS Subcellular localization image for GOLGB1 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 2
cytoskeleton 1
endosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GOLGB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0005794 Golgi apparatus IDA 22572157
GO:0005795 Golgi stack TAS 7691276
GO:0005801 cis-Golgi network IEA --
genes like me logo Genes that share ontologies with GOLGB1: view

Pathways & Interactions for GOLGB1 Gene

SuperPathways for GOLGB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GOLGB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0007030 Golgi organization TAS 7691276
genes like me logo Genes that share ontologies with GOLGB1: view

No data available for Pathways by source and SIGNOR curated interactions for GOLGB1 Gene

Drugs & Compounds for GOLGB1 Gene

(1) Drugs for GOLGB1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sucrose Experimental Pharma 0

(1) Additional Compounds for GOLGB1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Mannose 6-phosphate
  • alpha-D-Mannose-6-P
  • alpha-D-Mannose-6-phosphate
  • alpha-delta-Mannose-6-P
  • alpha-delta-Mannose-6-phosphate
  • D-Mannose 6-phosphate
genes like me logo Genes that share compounds with GOLGB1: view

Transcripts for GOLGB1 Gene

Unigene Clusters for GOLGB1 Gene

Golgin B1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GOLGB1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGB1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^
SP1: - - - - -
SP2: - - -
SP3: - - - - - -
SP4: -

ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22

Relevant External Links for GOLGB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GOLGB1 Gene

mRNA expression in normal human tissues for GOLGB1 Gene

Protein differential expression in normal tissues from HIPED for GOLGB1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (12.0), Peripheral blood mononuclear cells (11.5), and Salivary gland (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GOLGB1 Gene

SOURCE GeneReport for Unigene cluster for GOLGB1 Gene Hs.213389

genes like me logo Genes that share expression patterns with GOLGB1: view

Protein tissue co-expression partners for GOLGB1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GOLGB1 Gene

Orthologs for GOLGB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GOLGB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GOLGB1 35
  • 87.75 (n)
  • 85.06 (a)
  • 85 (a)
(Canis familiaris)
Mammalia GOLGB1 35
  • 89.11 (n)
  • 86.49 (a)
  • 86 (a)
(Mus musculus)
Mammalia Golgb1 35
  • 79.81 (n)
  • 76.24 (a)
Golgb1 16
Golgb1 36
  • 76 (a)
(Pan troglodytes)
Mammalia GOLGB1 35
  • 99.52 (n)
  • 99.05 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Golgb1 35
  • 79.19 (n)
  • 75.46 (a)
(Monodelphis domestica)
Mammalia GOLGB1 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia GOLGB1 36
  • 45 (a)
(Gallus gallus)
Aves GOLGB1 35
  • 61.41 (n)
  • 52.43 (a)
  • 49 (a)
(Anolis carolinensis)
Reptilia GOLGB1 36
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6338 35
(Danio rerio)
Actinopterygii golgb1 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea C02F12.7 37
  • 22 (a)
Species with no ortholog for GOLGB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GOLGB1 Gene

Gene Tree for GOLGB1 (if available)
Gene Tree for GOLGB1 (if available)

Paralogs for GOLGB1 Gene

No data available for Paralogs for GOLGB1 Gene

Variants for GOLGB1 Gene

Sequence variations from dbSNP and Humsavar for GOLGB1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs75275820 -- 121,721,108(+) ATAAA(A/G)AATAA intron-variant
rs75286144 -- 121,731,381(+) TTTTT(G/T)GAGAC intron-variant
rs111257816 -- 121,729,479(+) CACAA(C/T)CACAA intron-variant
rs80298921 -- 121,733,453(+) AACTA(C/T)TGAAA intron-variant
rs80171927 -- 121,673,696(+) CTATC(C/T)ATCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GOLGB1 Gene

Variant ID Type Subtype PubMed ID
nsv829703 CNV Loss 17160897
nsv516233 CNV Gain+Loss 19592680
nsv877383 CNV Loss 21882294

Variation tolerance for GOLGB1 Gene

Residual Variation Intolerance Score: 43.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.98; 96.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GOLGB1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLGB1 Gene

Disorders for GOLGB1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for GOLGB1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • paedophilia
gastric dilatation
  • stomach dilatation
gastrointestinal lymphoma
blue cone monochromacy
  • blue cone monochromatism
paraphilia disorder
- elite association

Relevant External Links for GOLGB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GOLGB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GOLGB1 Gene

Publications for GOLGB1 Gene

  1. The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. (PMID: 15004235) Oka T. … Krieger M. (Mol. Biol. Cell 2004) 2 23 67
  2. Giantin, a novel conserved Golgi membrane protein containing a cytoplasmic domain of at least 350 kDa. (PMID: 7691276) Linstedt A.D. … Hauri H.P. (Mol. Biol. Cell 1993) 2 23 67
  3. Emerging new roles of GM130, a cis-Golgi matrix protein, in higher order cell functions. (PMID: 20197635) Nakamura N. (J. Pharmacol. Sci. 2010) 23 67
  4. Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation. (PMID: 19103756) Lopez-Sanchez I. … Lazo P.A. (Mol. Cell. Biol. 2009) 23 67
  5. Golgi dysfunction is a common feature in idiopathic human pulmonary hypertension and vascular lesions in SHIV-nef-infected macaques. (PMID: 19648286) Sehgal P.B. … Flores S.C. (Am. J. Physiol. Lung Cell Mol. Physiol. 2009) 23 67

Products for GOLGB1 Gene

Sources for GOLGB1 Gene

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