GOLGA6A Gene
protein-coding GIFtS: 43
GCID: GC15M074363
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golgin A6 family, member A(Previous names: golgi autoantigen, golgin subfamily a, member 6, golgi...)
(Previous symbol: GOLGA6)
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Aliases
for GOLGA6A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Golgin A6 Family, Member A1 2 | | Golgi Autoantigen, Golgin Subfamily A, Member 61 2 | | GLP1 2 3 5 | | Golgin-Like Protein2 3 | | GOLGA61 2 3 5 | | Golgin Linked To PML2 3 | | Golgi Autoantigen, Golgin Subfamily A, 61 2 | | Golgin Subfamily A Member 6A2 | | Golgi Autoantigen, Golgin Subfamily A, 6A1 2 | | |
Export aliases for GOLGA6A gene to outside databasesPrevious GC identifer: GC15M072154 |
Summaries
for GOLGA6A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GOLGA6A:
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway,consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubulesare thought to be important for the reorganization of the Golgi after it fragments during mitosis. The protein encodedby this gene is a member of the golgin family of proteins, whose members localize to the Golgi. This gene is found ina large, low copy repeat sequence or duplicon that is found in multiple copies, that are greather than 90% similar, onchromosome 15. Duplicons are associated with deletions, inversions and other chromosome rearrangements that underliegenomic disease. The protein encoded by this gene is thought to be a functional golgin protein while the majority ofthe related copies of this gene are thought to be transcribed pseudogenes. (provided by RefSeq, Jul 2008)
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Genomic Views
for GOLGA6A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for GOLGA6A
Other transcription factors
Search SABiosciences Chromatin IP Primers for GOLGA6A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GOLGA6A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q24.1 Ensembl cytogenetic band: 15q24.1 HGNC cytogenetic band: 15q24.1GOLGA6A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M074363: view genomic region
(about GC identifiers)
Start:
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74,362,198 bp from pter |
End:
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74,374,891 bp from pter |
Size:
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12,694 bases |
Orientation:
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minus strand |
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Proteins
for GOLGA6A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GOG6A_HUMAN, Q9NYA3 (See
protein sequence)Recommended Name: Golgin subfamily A member 6A Size: 693 amino acids; 79946 Da
Caution: Maps to a duplicated region on chromosome 15; the gene is present in at least 4 almost identical copies
Secondary accessions: A8K959 Q9NYA7Explore the universe of human proteins at neXtProt for GOLGA6A: NX_Q9NYA3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NYA3
GOLGA6A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001033729.2
ENSEMBL proteins: ENSP00000290438
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005794 | Golgi apparatus |
IEA | -- |
GOLGA6A for ontologies About GeneDecksing
GOLGA6A Antibody Products:
Assay Products for GOLGA6A: |
Protein
Domains /
Families
for GOLGA6A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GOLGA6A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NYA3ProtoNet protein and cluster: Q9NYA3 UniProtKB/Swiss-Prot: GOG6A_HUMAN, Q9NYA3Similarity: Belongs to the GOLGA6 family |
Function
for GOLGA6A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GOLGA6A
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|
Pathways & Interactions
for GOLGA6A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GOLGA6A
|
Drugs & Compounds
for GOLGA6A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GOLGA6A
Search CenterWatch for drugs/clinical trials and news about GOLGA6A / GOG6A
|
Transcripts
for GOLGA6A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GOLGA6A gene: NM_001038640.2 Unigene Clusters for GOLGA6A: Golgin A6 family, member A Hs.546408 [show with all ESTs], Hs.672474 [show with all ESTs]Unigene Representative Sequences: NM_018652, NM_0011452244 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000290438(uc002axa.1) ENST00000562157 ENST00000569486 ENST00000568723
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GOLGA6A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GOLGA6A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GOLGA6A
Browse OriGene validated miRNA SYBR primer pairs
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Additional cDNA sequence: AF263742.1 BC131515.1 4 DOTS entries: DT.121071225 DT.87015494 DT.102821761 DT.121036350 16 AceView cDNA sequences: AA460585 AI671291 AI621056 BE550281 BV197492 BV196285 BV196284 BF510391 BV197345 BX103649 AF263742 BV197626 BV197346 AA620905 AA461511 AI073403
GeneLoc Exon Structure
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Expression
for GOLGA6A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GOLGA6A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCTTCTTT
About this image
See GOLGA6A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GOLGA6A
SOURCE GeneReport for Unigene clusters: Hs.546408 Hs.672474
UniProtKB/Swiss-Prot: GOG6A_HUMAN, Q9NYA3Tissue specificity: Highly expressed in seminiferous tubes in testis. Highly expressed in spermatids, barely detectablein late pachytene spermatocytes, and not detectable in spermatogonia. Detected at intermediate levels in pancreas andlymph nodes, and at much lower levels in spleen, peripheral blood leukocytes, skeletal muscle, liver, lung, placenta,brain and heart
SABiosciences Custom PCR Arrays for GOLGA6A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GOLGA6A
Browse OriGene validated miRNA SYBR primer pairs
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Orthologs
for GOLGA6A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for GOLGA6A gene from 1/4 species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
fruit fly
(Drosophila melanogaster) |
Insecta |
GM1306 |
GM130 |
16(a) |
1 → many |
2R(18012072-18015002) |
ENSEMBL Gene Tree for GOLGA6A (if available)
TreeFam Gene Tree for GOLGA6A (if available) |
Paralogs
for GOLGA6A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GOLGA6A gene
- GOLGA6B1 2 GOLGA6D1 2 GOLGA6C1 2 GOLGA8N2 LOC6436962 GOLGA8G2 GOLGA8O2 GOLGA8F2
- GOLGA6L22 GOLGA8I2 GOLGA6L62 GOLGA6L12 GOLGA6L92 GOLGA8B2 GOLGA8A2 GOLGA8K2
- GOLGA6L32 GOLGA6L102 GOLGA8J2 LOC4402332 GOLGA22 LOC6423252 GOLGA8M2 GOLGA8H2
18/29 SIMAP similar genes for GOLGA6A using alignment to 1 protein entry: GOG6A_HUMAN(see all similar genes):GOLGA6 GOLGA6B GOLGA6D GOLGA6C DKFZp564E0216 GOLGA2LY
DKFZp686K0319 GOLGA2L1 GOLGA8F GOLGA2 GOLGA8DP GOLGA8I
GOLGA8M GOLGA8O GOLGA8Q GOLGA8R GOLGA8CP GOLGA8H
GOLGA6A for paralogs About GeneDecksing
|
Genomic Variants
for GOLGA6A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GOLGA6A (74362198 - 74374891 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for GOLGA6A
8 CNVs: 35337 87742 66835 32043 3968 35336 2196 77005
1 Inversion: 37170 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GOLGA6A |
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Disorders
/ Diseases
for GOLGA6A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GOLGA6A for disorders About GeneDecksing
OMIM gene information: 610288
OMIM disorders: --
3  diseases for GOLGA6A: About MalaCardsphobic disorder congenital fibrosarcoma fibrosarcoma
1 disease from the University of Copenhagen DISEASES database for GOLGA6A:Congenital fibrosarcoma Export disorders for GOLGA6A gene to outside databases
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Publications
for GOLGA6A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GOLGA6A gene integrated from 9 sources:
(articles sorted by number of sources associating them with GOLGA6A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of a golgin-related gene from the large- scale polymorphism linked to the PML gene. (PubMed id 11161787)1, 2, 3, 9 Gilles F.... Zelenetz A.D. (2000)
- Human chromosome 15q11-q14 regions of rearrangements contain clusters of LCR15 duplicons. (PubMed id 11896453)1, 9 Pujana M.A....Estivill X. (2002)
- Additional complexity on human chromosome 15q: identification of a set of newly recognized duplicons (LCR15) on 15q11-q13, 15q24, and 15q26. (PubMed id 11156619)1, 9 Pujana M.A....Estivill X. (2001)
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Neocentromeres in 15q24-26 map to duplicons which flanked an ancestral centromere in 15q25. (PubMed id 12915487)1 Ventura M.... Rocchi M. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- A polymorphic genomic duplication on human chromosome 15 is a susceptibility factor for panic and phobic disorders. (PubMed id 11509185)1 Gratacos M....Estivill X. (2001)
|
External Searches for GOLGA6A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing GOLGA6A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GOLGA6A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GOLGA6A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GOLGA6A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GOLGA6A gene:
Search GeneIP for patents involving GOLGA6A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GOLGA6A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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