Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GOLGA5 Gene

Aliases for GOLGA5 Gene

  • Golgin A5 2 3 5
  • Cell Proliferation-Inducing Gene 31 Protein 3 4
  • Golgi Autoantigen, Golgin Subfamily A, 5 2 3
  • Golgi Integral Membrane Protein 5 2 3
  • RET-Fused Gene 5 Protein 3 4
  • Golgin-84 3 4
  • RFG5 3 4
  • Golgin Subfamily A Member 5 3
  • Protein Ret-II 4
  • GOLIM5 3
  • Ret-II 3
  • RETII 4

External Ids for GOLGA5 Gene

Previous GeneCards Identifiers for GOLGA5 Gene

  • GC14P090767
  • GC14P087077
  • GC14P091250
  • GC14P092330
  • GC14P093260
  • GC14P073443

Summaries for GOLGA5 Gene

Entrez Gene Summary for GOLGA5 Gene

  • The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the ret proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5. A pseudogene of this gene is located on the short arm of chromosome 5. [provided by RefSeq, Jul 2013]

GeneCards Summary for GOLGA5 Gene

GOLGA5 (Golgin A5) is a Protein Coding gene. Diseases associated with GOLGA5 include Differentiated Thyroid Carcinoma. Among its related pathways are Vesicle-mediated transport and Intra-Golgi traffic. GO annotations related to this gene include protein homodimerization activity and Rab GTPase binding.

UniProtKB/Swiss-Prot for GOLGA5 Gene

  • Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.

Gene Wiki entry for GOLGA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLGA5 Gene

Genomics for GOLGA5 Gene

Regulatory Elements for GOLGA5 Gene

Enhancers for GOLGA5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F092120 0.5 ENCODE 14.8 -672.1 -672113 2.9 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 CPSF2 NDUFB1 TRIP11 GOLGA5 ATXN3 GC14P092168
GH14F092038 1.1 ENCODE 11.2 -754.4 -754377 3.3 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TRIP11 GOLGA5 TC2N CATSPERB ATXN3 NDUFB1 PIR36842
GH14F092989 0.7 ENCODE 9.9 +196.2 196238 2.6 ZNF680 FEZF1 NR2F2 ZNF335 SMARCA4 ZNF157 POLR2A SCRT2 ZNF26 TRIM24 CHGA GOLGA5 ITPK1 PIR52280 GC14P093068 ITPK1-AS1
GH14F093149 1 Ensembl ENCODE 9.7 +356.7 356667 2.9 ELF3 PKNOX1 ARID4B BRCA1 RARA YY1 GTF3C2 ZNF366 POLR3A RCOR1 GOLGA5 ENSG00000258595 MOAP1
GH14F092792 0.6 ENCODE 5.8 0.0 -44 3.2 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 CPSF2 TRIP11 GOLGA5 LGMN
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GOLGA5 on UCSC Golden Path with GeneCards custom track

Promoters for GOLGA5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000652546 369 2001 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 KLF13

Genomic Location for GOLGA5 Gene

Chromosome:
14
Start:
92,794,231 bp from pter
End:
92,839,963 bp from pter
Size:
45,733 bases
Orientation:
Plus strand

Genomic View for GOLGA5 Gene

Genes around GOLGA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLGA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLGA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA5 Gene

Proteins for GOLGA5 Gene

  • Protein details for GOLGA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBA6-GOGA5_HUMAN
    Recommended name:
    Golgin subfamily A member 5
    Protein Accession:
    Q8TBA6
    Secondary Accessions:
    • C9JRU1
    • O95287
    • Q03962
    • Q2TS49
    • Q9UQQ7

    Protein attributes for GOLGA5 Gene

    Size:
    731 amino acids
    Molecular mass:
    83024 Da
    Quaternary structure:
    • Homodimer. Interacts with RAB1A that has been activated by GTP-binding, and possibly also with OCRL1. Interacts with isoform CASP of CUX1.
    SequenceCaution:
    • Sequence=CAA33787.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. A chimeric cDNA originating from chromosomes 14 and 10.; Evidence={ECO:0000305};

    Alternative splice isoforms for GOLGA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOLGA5 Gene

Post-translational modifications for GOLGA5 Gene

  • Highly phosphorylated during mitosis. Phosphorylation is barely detectable during interphase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GOLGA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for GOLGA5

No data available for DME Specific Peptides for GOLGA5 Gene

Domains & Families for GOLGA5 Gene

Protein Domains for GOLGA5 Gene

Suggested Antigen Peptide Sequences for GOLGA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GOLGA5: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GOLGA5 Gene

Function for GOLGA5 Gene

Molecular function for GOLGA5 Gene

GENATLAS Biochemistry:
Golgi autoantigen,golgin-84,subfamily A,member 5,ubiquitously expressed,abundantly in testis,forming the RET-II oncogene when fused by its coiled coil domain to the RET tyrosine kinase domain
UniProtKB/Swiss-Prot Function:
Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.

Gene Ontology (GO) - Molecular Function for GOLGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017137 Rab GTPase binding IDA 12538640
GO:0042803 protein homodimerization activity IPI 9915833
genes like me logo Genes that share ontologies with GOLGA5: view
genes like me logo Genes that share phenotypes with GOLGA5: view

Human Phenotype Ontology for GOLGA5 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLGA5 Gene

Localization for GOLGA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLGA5 Gene

Golgi apparatus membrane; Single-pass type IV membrane protein. Note=Found throughout the Golgi, both on cisternae and, at higher abundance, on the tubulo-vesicular structures of the cis-Golgi network.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GOLGA5 Gene COMPARTMENTS Subcellular localization image for GOLGA5 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 2
nucleus 2
cytosol 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GOLGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA,IDA 9915833
GO:0005801 cis-Golgi network IDA 12538640
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA,IDA 9915833
genes like me logo Genes that share ontologies with GOLGA5: view

Pathways & Interactions for GOLGA5 Gene

genes like me logo Genes that share pathways with GOLGA5: view

Pathways by source for GOLGA5 Gene

Gene Ontology (GO) - Biological Process for GOLGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000301 retrograde transport, vesicle recycling within Golgi IBA --
GO:0007030 Golgi organization IEA,IMP 12538640
GO:0048193 Golgi vesicle transport IMP 12538640
genes like me logo Genes that share ontologies with GOLGA5: view

No data available for SIGNOR curated interactions for GOLGA5 Gene

Drugs & Compounds for GOLGA5 Gene

(2) Drugs for GOLGA5 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GOLGA5: view

Transcripts for GOLGA5 Gene

Unigene Clusters for GOLGA5 Gene

Golgin A5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA5 Gene

No ASD Table

Relevant External Links for GOLGA5 Gene

GeneLoc Exon Structure for
GOLGA5
ECgene alternative splicing isoforms for
GOLGA5

Expression for GOLGA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GOLGA5 Gene

Protein differential expression in normal tissues from HIPED for GOLGA5 Gene

This gene is overexpressed in Nasal epithelium (35.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GOLGA5 Gene



Protein tissue co-expression partners for GOLGA5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GOLGA5 Gene:

GOLGA5

SOURCE GeneReport for Unigene cluster for GOLGA5 Gene:

Hs.104320

mRNA Expression by UniProt/SwissProt for GOLGA5 Gene:

Q8TBA6-GOGA5_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in seminiferous tubules and Leydig cells in testis, and detected at much lower levels in the other tissues tested. Expression is very low or not detectable in spermatozoa.
genes like me logo Genes that share expression patterns with GOLGA5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GOLGA5 Gene

Orthologs for GOLGA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for GOLGA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOLGA5 34 35
  • 99.36 (n)
dog
(Canis familiaris)
Mammalia GOLGA5 34 35
  • 89.32 (n)
cow
(Bos Taurus)
Mammalia GOLGA5 34 35
  • 89.1 (n)
rat
(Rattus norvegicus)
Mammalia Golga5 34
  • 83.97 (n)
mouse
(Mus musculus)
Mammalia Golga5 34 16 35
  • 83.04 (n)
oppossum
(Monodelphis domestica)
Mammalia GOLGA5 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 73 (a)
OneToMany
-- 35
  • 62 (a)
OneToMany
chicken
(Gallus gallus)
Aves GOLGA5 34 35
  • 74.17 (n)
lizard
(Anolis carolinensis)
Reptilia GOLGA5 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia golga5 34
  • 69.16 (n)
Str.15767 34
zebrafish
(Danio rerio)
Actinopterygii golga5 34 35
  • 59.99 (n)
wufd50h11 34
fruit fly
(Drosophila melanogaster)
Insecta Golgin84 35
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T24B1.1 34 35
  • 44.68 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4460 35
  • 34 (a)
OneToOne
Species where no ortholog for GOLGA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GOLGA5 Gene

ENSEMBL:
Gene Tree for GOLGA5 (if available)
TreeFam:
Gene Tree for GOLGA5 (if available)

Paralogs for GOLGA5 Gene

Pseudogenes.org Pseudogenes for GOLGA5 Gene

genes like me logo Genes that share paralogs with GOLGA5: view

No data available for Paralogs for GOLGA5 Gene

Variants for GOLGA5 Gene

Sequence variations from dbSNP and Humsavar for GOLGA5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10129308 -- 92,831,686(+) TCATA(C/G)TACCA intron-variant
rs10131016 -- 92,806,419(+) GTGAT(A/T)CTCCT intron-variant
rs10134439 -- 92,810,871(+) gtcac(A/G)ttcca intron-variant
rs10135267 -- 92,804,502(+) ccatc(A/G)ctttc intron-variant
rs10135352 -- 92,802,585(+) ttttt(C/T)atagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GOLGA5 Gene

Variant ID Type Subtype PubMed ID
nsv522417 CNV gain 19592680
nsv819955 CNV loss 19587683

Variation tolerance for GOLGA5 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.20; 80.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GOLGA5 Gene

Human Gene Mutation Database (HGMD)
GOLGA5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLGA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLGA5 Gene

Disorders for GOLGA5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GOLGA5 Gene - From: Orphanet

Disorder Aliases PubMed IDs
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

GOGA5_HUMAN
  • Note=A chromosomal aberration involving GOLGA5 is found in papillary thyroid carcinomas (PTCs). Translocation t(10;14)(q11;q32) with RET. The translocation generates the RET/GOLGA5 (PTC5) oncogene. {ECO:0000269 PubMed:2734021, ECO:0000269 PubMed:9443391}.

Relevant External Links for GOLGA5

Genetic Association Database (GAD)
GOLGA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GOLGA5
genes like me logo Genes that share disorders with GOLGA5: view

No data available for Genatlas for GOLGA5 Gene

Publications for GOLGA5 Gene

  1. Detection of a novel type of Ret rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved Ret-fused gene RFG5. (PMID: 9443391) Klugbauer S. … Rabes H.M. (Cancer Res. 1998) 2 3 4 22 64
  2. Golgin tethers define subpopulations of COPI vesicles. (PMID: 15718469) Malsam J. … Warren G. (Science 2005) 3 4 22 64
  3. The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. (PMID: 15004235) Oka T. … Krieger M. (Mol. Biol. Cell 2004) 2 3 22 64
  4. The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation. (PMID: 12538640) Diao A. … Lowe M. (J. Cell Biol. 2003) 3 4 22 64
  5. Identification and characterization of golgin-84, a novel Golgi integral membrane protein with a cytoplasmic coiled-coil domain. (PMID: 9915833) Bascom R.A. … Nussbaum R.L. (J. Biol. Chem. 1999) 3 4 22 64

Products for GOLGA5 Gene

Sources for GOLGA5 Gene

Content
Loading form....