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Aliases for GOLGA5 Gene

Aliases for GOLGA5 Gene

  • Golgin A5 2 3
  • Cell Proliferation-Inducing Gene 31 Protein 3 4
  • Golgi Autoantigen, Golgin Subfamily A, 5 2 3
  • Golgi Integral Membrane Protein 5 2 3
  • RET-Fused Gene 5 Protein 3 4
  • Golgin-84 3 4
  • RFG5 3 4
  • Protein Ret-II 4
  • GOLIM5 3
  • Ret-II 3
  • RETII 4

External Ids for GOLGA5 Gene

Previous GeneCards Identifiers for GOLGA5 Gene

  • GC14P090767
  • GC14P087077
  • GC14P091250
  • GC14P092330
  • GC14P093260
  • GC14P073443

Summaries for GOLGA5 Gene

Entrez Gene Summary for GOLGA5 Gene

  • The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the ret proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5. A pseudogene of this gene is located on the short arm of chromosome 5. [provided by RefSeq, Jul 2013]

GeneCards Summary for GOLGA5 Gene

GOLGA5 (Golgin A5) is a Protein Coding gene. Diseases associated with GOLGA5 include differentiated thyroid carcinoma and oculocerebrorenal syndrome. GO annotations related to this gene include protein homodimerization activity and Rab GTPase binding.

UniProtKB/Swiss-Prot for GOLGA5 Gene

  • Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.

Gene Wiki entry for GOLGA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLGA5 Gene

Genomics for GOLGA5 Gene

Regulatory Elements for GOLGA5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GOLGA5 Gene

92,794,231 bp from pter
92,839,963 bp from pter
45,733 bases
Plus strand

Genomic View for GOLGA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GOLGA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA5 Gene

Proteins for GOLGA5 Gene

  • Protein details for GOLGA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Golgin subfamily A member 5
    Protein Accession:
    Secondary Accessions:
    • C9JRU1
    • O95287
    • Q03962
    • Q2TS49
    • Q9UQQ7

    Protein attributes for GOLGA5 Gene

    731 amino acids
    Molecular mass:
    83024 Da
    Quaternary structure:
    • Homodimer. Interacts with RAB1A that has been activated by GTP-binding, and possibly also with OCRL1. Interacts with isoform CASP of CUX1.
    • Sequence=CAA33787.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. A chimeric cDNA originating from chromosomes 14 and 10.; Evidence={ECO:0000305};

    Alternative splice isoforms for GOLGA5 Gene


neXtProt entry for GOLGA5 Gene

Proteomics data for GOLGA5 Gene at MOPED

Post-translational modifications for GOLGA5 Gene

  • Highly phosphorylated during mitosis. Phosphorylation is barely detectable during interphase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GOLGA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GOLGA5 Gene

Domains & Families for GOLGA5 Gene

Protein Domains for GOLGA5 Gene


Suggested Antigen Peptide Sequences for GOLGA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GOLGA5: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GOLGA5 Gene

Function for GOLGA5 Gene

Molecular function for GOLGA5 Gene

GENATLAS Biochemistry:
Golgi autoantigen,golgin-84,subfamily A,member 5,ubiquitously expressed,abundantly in testis,forming the RET-II oncogene when fused by its coiled coil domain to the RET tyrosine kinase domain
UniProtKB/Swiss-Prot Function:
Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.

Gene Ontology (GO) - Molecular Function for GOLGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0017137 Rab GTPase binding IDA 12538640
GO:0030674 protein binding, bridging IEA --
GO:0042803 protein homodimerization activity IPI 9915833
genes like me logo Genes that share ontologies with GOLGA5: view

Phenotypes for GOLGA5 Gene

GenomeRNAi human phenotypes for GOLGA5:
genes like me logo Genes that share phenotypes with GOLGA5: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GOLGA5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLGA5 Gene

Localization for GOLGA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLGA5 Gene

Golgi apparatus membrane; Single-pass type IV membrane protein. Note=Found throughout the Golgi, both on cisternae and, at higher abundance, on the tubulo-vesicular structures of the cis-Golgi network.

Subcellular locations from

Jensen Localization Image for GOLGA5 Gene COMPARTMENTS Subcellular localization image for GOLGA5 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GOLGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000137 Golgi cis cisterna IEA --
GO:0000138 Golgi trans cisterna IEA --
GO:0000139 Golgi membrane IBA --
GO:0005794 Golgi apparatus IDA 9915833
GO:0005797 Golgi medial cisterna IEA --
genes like me logo Genes that share ontologies with GOLGA5: view

Pathways & Interactions for GOLGA5 Gene

SuperPathways for GOLGA5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GOLGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000301 retrograde transport, vesicle recycling within Golgi IBA --
GO:0007030 Golgi organization IMP 12538640
GO:0048193 Golgi vesicle transport IMP 12538640
genes like me logo Genes that share ontologies with GOLGA5: view

No data available for Pathways by source and SIGNOR curated interactions for GOLGA5 Gene

Drugs & Compounds for GOLGA5 Gene

(2) Drugs for GOLGA5 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
tyrosine Nutra 547
genes like me logo Genes that share compounds with GOLGA5: view

Transcripts for GOLGA5 Gene

mRNA/cDNA for GOLGA5 Gene

Unigene Clusters for GOLGA5 Gene

Golgin A5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GOLGA5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA5 Gene

No ASD Table

Relevant External Links for GOLGA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GOLGA5 Gene

mRNA expression in normal human tissues for GOLGA5 Gene

Protein differential expression in normal tissues from HIPED for GOLGA5 Gene

This gene is overexpressed in Nasal epithelium (35.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GOLGA5 Gene

SOURCE GeneReport for Unigene cluster for GOLGA5 Gene Hs.104320

mRNA Expression by UniProt/SwissProt for GOLGA5 Gene

Tissue specificity: Ubiquitous. Highly expressed in seminiferous tubules and Leydig cells in testis, and detected at much lower levels in the other tissues tested. Expression is very low or not detectable in spermatozoa.
genes like me logo Genes that share expression patterns with GOLGA5: view

Protein tissue co-expression partners for GOLGA5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GOLGA5 Gene

Orthologs for GOLGA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for GOLGA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GOLGA5 35
  • 89.1 (n)
  • 89.47 (a)
  • 89 (a)
(Canis familiaris)
Mammalia GOLGA5 35
  • 89.32 (n)
  • 91.1 (a)
  • 91 (a)
(Mus musculus)
Mammalia Golga5 35
  • 83.04 (n)
  • 84.32 (a)
Golga5 16
Golga5 36
  • 84 (a)
(Pan troglodytes)
Mammalia GOLGA5 35
  • 99.36 (n)
  • 99.45 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Golga5 35
  • 83.97 (n)
  • 84.89 (a)
(Monodelphis domestica)
Mammalia GOLGA5 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
-- 36
  • 73 (a)
(Gallus gallus)
Aves GOLGA5 35
  • 74.17 (n)
  • 76.54 (a)
  • 75 (a)
(Anolis carolinensis)
Reptilia GOLGA5 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia golga5 35
  • 69.16 (n)
  • 70.94 (a)
Str.15767 35
(Danio rerio)
Actinopterygii golga5 35
  • 59.99 (n)
  • 61.75 (a)
wufd50h11 35
golga5 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta Golgin84 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea T24B1.1 35
  • 44.68 (n)
  • 30.05 (a)
T24B1.1 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4460 36
  • 34 (a)
Species with no ortholog for GOLGA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GOLGA5 Gene

Gene Tree for GOLGA5 (if available)
Gene Tree for GOLGA5 (if available)

Paralogs for GOLGA5 Gene Pseudogenes for GOLGA5 Gene

genes like me logo Genes that share paralogs with GOLGA5: view

No data available for Paralogs for GOLGA5 Gene

Variants for GOLGA5 Gene

Sequence variations from dbSNP and Humsavar for GOLGA5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs11707 -- 92,839,742(-) TACAG(A/T)TGGTC utr-variant-3-prime
rs743219 -- 92,812,318(+) TCTCC(A/G)TAGAT intron-variant
rs743220 -- 92,812,236(+) AAAAC(A/C)TGTCC intron-variant
rs927294 -- 92,813,404(-) TCAGG(A/C)AAGTT intron-variant
rs1016688 -- 92,793,086(-) TCGCC(C/T)GTTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GOLGA5 Gene

Variant ID Type Subtype PubMed ID
nsv819955 CNV Loss 19587683
nsv522417 CNV Gain 19592680

Variation tolerance for GOLGA5 Gene

Residual Variation Intolerance Score: 63.44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.20; 80.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GOLGA5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLGA5 Gene

Disorders for GOLGA5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GOLGA5 Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
oculocerebrorenal syndrome
  • lowe syndrome
- elite association


  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving GOLGA5 is found in thyroid papillary carcinomas. Translocation t(10;14)(q11;q32) with RET. The translocation generates the RET/GOLGA5 (PTC5) oncogene which was found in 2 cases of PACT in children exposed to radioactive fallout after Chernobyl.

Relevant External Links for GOLGA5

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GOLGA5: view

No data available for Genatlas for GOLGA5 Gene

Publications for GOLGA5 Gene

  1. The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. (PMID: 15004235) Oka T. … Krieger M. (Mol. Biol. Cell 2004) 2 23 67
  2. Detection of a novel type of Ret rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved Ret-fused gene RFG5. (PMID: 9443391) Klugbauer S. … Rabes H.M. (Cancer Res. 1998) 2 23 67
  3. The COG complex, Rab6 and COPI define a novel Golgi retrograde trafficking pathway that is exploited by SubAB toxin. (PMID: 19678899) Smith R.D. … Lupashin V.V. (Traffic 2009) 23 67
  4. Chlamydia causes fragmentation of the Golgi compartment to ensure reproduction. (PMID: 19060882) Heuer D. … Meyer T.F. (Nature 2009) 23 67
  5. Localization and domain characterization of Arabidopsis golgin candidates. (PMID: 18182439) Latijnhouwers M. … Carvalho C.M. (J. Exp. Bot. 2007) 23 67

Products for GOLGA5 Gene

Sources for GOLGA5 Gene

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