Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GOLGA5 Gene

protein-coding   GIFtS: 54
GCID: GC14P093260

Golgin A5

(Previous names: golgi autoantigen, golgin subfamily a, 5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Golgin A51 2     Golgin Subfamily A Member 52
RFG52 3 5     golgin-842
Golgi Autoantigen, Golgin Subfamily A, 51 2     ret-II2
Golgi Integral Membrane Protein 51 2     Golgin-843
Cell Proliferation-Inducing Gene 31 Protein2 3     RETII3
RET-Fused Gene 5 Protein2 3     Protein Ret-II3
GOLIM52     PTC55

External Ids:    HGNC: 44281   Entrez Gene: 99502   Ensembl: ENSG000000664557   OMIM: 6069185   UniProtKB: Q8TBA63   

Export aliases for GOLGA5 gene to outside databases

Previous GC identifers: GC14P090767 GC14P087077 GC14P091250 GC14P092330 GC14P073443


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GOLGA5 Gene:
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory
pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and
microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis.
This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein is a coiled-coil
membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations
involving this gene and the ret proto-oncogene have been found in tumor tissues; the chimeric sequences have been
designated RET-II and PTC5. A pseudogene of this gene is located on the short arm of chromosome 5. (provided by
RefSeq, Jul 2013)

GeneCards Summary for GOLGA5 Gene: 
GOLGA5 (golgin A5) is a protein-coding gene. Diseases associated with GOLGA5 include sigmoid colon cancer, and oculocerebrorenal syndrome. GO annotations related to this gene include Rab GTPase binding and protein homodimerization activity.

UniProtKB/Swiss-Prot: GOGA5_HUMAN, Q8TBA6
Function: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved
in intra-Golgi retrograde transport

Gene Wiki entry for GOLGA5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GOLGA5 gene promoter:
         SREBP-1c   Pax-6   SREBP-1b   IRF-2   POU2F1   SREBP-1a   POU2F1a   Chx10   MRF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGOLGA5 promoter sequence
   Search SABiosciences Chromatin IP Primers for GOLGA5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GOLGA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.12   Ensembl cytogenetic band:  14q32.12   HGNC cytogenetic band: 14q32.12

GOLGA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GOLGA5 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P093260:  view genomic region     (about GC identifiers)

Start:
93,260,576 bp from pter      End:
93,306,308 bp from pter
Size:
45,733 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GOGA5_HUMAN, Q8TBA6 (See protein sequence)
Recommended Name: Golgin subfamily A member 5  
Size: 731 amino acids; 83024 Da
Subunit: Homodimer. Interacts with RAB1A that has been activated by GTP-binding, and possibly also with OCRL1.
Interacts with isoform CASP of CUX1
Subcellular location: Golgi apparatus membrane; Single-pass type IV membrane protein. Note=Found throughout the
Golgi, both on cisternae and, at higher abundance, on the tubulo-vesicular structures of the cis-Golgi network
Sequence caution: Sequence=CAA33787.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. A chimeric cDNA
originating from chromosomes 14 and 10;
Secondary accessions: C9JRU1 O95287 Q03962 Q2TS49 Q9UQQ7
Alternative splicing: 2 isoforms:  Q8TBA6-1   Q8TBA6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GOLGA5: NX_Q8TBA6

Explore proteomics data for GOLGA5 at MOPED 

Post-translational modifications:

  • UniProtKB: Highly phosphorylated during mitosis. Phosphorylation is barely detectable during interphase
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TBA6

  • GOLGA5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GOLGA5 Protein Expression
    REFSEQ proteins: NP_005104.3  
    ENSEMBL proteins: 
     ENSP00000163416   ENSP00000452601   ENSP00000348252  

    Human Recombinant Protein Products for GOLGA5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GOLGA5
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for GOLGA5
    GenScript Custom Purified and Recombinant Proteins Services for GOLGA5
    Novus Biologicals GOLGA5 Proteins
    Novus Biologicals GOLGA5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GOLGA5 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005794Golgi apparatus IDA--
    GO:0005801cis-Golgi network IDA12538640
    GO:0016021integral to membrane IDA9915833
    GO:0031985Golgi cisterna IDA12538640

    GOLGA5 for ontologies           About GeneDecksing



    GOLGA5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GOLGA5
    GenScript Custom Superior Antibodies Services for GOLGA5
    Novus Biologicals GOLGA5 Antibodies
    Abcam antibodies for GOLGA5
    Cloud-Clone Corp. Antibodies for GOLGA5 
    ThermoFisher Antibody for GOLGA5
    LSBio Antibodies in human, mouse, rat for GOLGA5 

    Assay Products for GOLGA5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GOLGA5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GOLGA5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GOLGA5 
    Cloud-Clone Corp. CLIAs for GOLGA5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019177 Golgin_subfamily_A_member_5

    Graphical View of Domain Structure for InterPro Entry Q8TBA6

    ProtoNet protein and cluster: Q8TBA6


    GOLGA5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GOGA5_HUMAN, Q8TBA6
    Function: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved
    in intra-Golgi retrograde transport

         Genatlas biochemistry entry for GOLGA5:
    Golgi autoantigen,golgin-84,subfamily A,member 5,ubiquitously expressed,abundantly in testis,forming the RET-II
    oncogene when fused by its coiled coil domain to the RET tyrosine kinase domain

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0017137Rab GTPase binding IDA12538640
    GO:0042803protein homodimerization activity IPI9915833
         
    GOLGA5 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GOLGA5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GOLGA5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GOLGA5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GOLGA5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GOLGA5
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate GOLGA5:
    hsa-miR-670 hsa-miR-3920
    SwitchGear 3'UTR luciferase reporter plasmidGOLGA5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GOLGA5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GOLGA5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GOLGA5
    Sirion Biotech Customized adenovirus for overexpression of GOLGA5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GOLGA5 (see all 7)
    OriGene ORF clones in mouse, rat for GOLGA5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GOLGA5 (NM_005113)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GOLGA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GOLGA5
    Sirion Biotech Customized lentivirus for stable overexpression of GOLGA5 
                         Customized lentivirus expression plasmids for stable overexpression of GOLGA5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GOLGA5
    Search LifeMap BioReagents cell lines for GOLGA5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOLGA5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GOLGA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/11 Interacting proteins for GOLGA5 (Q8TBA63 ENSP000001634164) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUX1P398803, ENSP000002925354I2D: score=1 I2D: score=1 STRING: ENSP00000292535
    RAB1AP628203, ENSP000003872864I2D: score=2 STRING: ENSP00000387286
    OCRLQ019683, ENSP000003601544I2D: score=2 STRING: ENSP00000360154
    MEIS1O004703I2D: score=5 
    MTMR9Q96QG73I2D: score=5 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007030Golgi organization IMP12538640
    GO:0048193Golgi vesicle transport IMP12538640

    GOLGA5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GOLGA5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GOLGA5 (GOGA5)

    1 HMDB Compound for GOLGA5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 Novoseek inferred chemical compound relationship for GOLGA5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 15.7 1 9915833 (1)

    Search CenterWatch for drugs/clinical trials and news about GOLGA5 / GOGA5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GOLGA5 gene: 
    NM_005113.3  

    Unigene Cluster for GOLGA5:

    Golgin A5
    Hs.104320  [show with all ESTs]
    Unigene Representative Sequence: NM_005113
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000163416(uc001yaz.1) ENST00000555793 ENST00000554700 ENST00000355976(uc001yba.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GOLGA5
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate GOLGA5:
    hsa-miR-670 hsa-miR-3920
    SwitchGear 3'UTR luciferase reporter plasmidGOLGA5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GOLGA5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GOLGA5
    Clone
    Products:
         
    OriGene clones in human, mouse for GOLGA5 (see all 7)
    OriGene ORF clones in mouse, rat for GOLGA5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GOLGA5 (NM_005113)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GOLGA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GOLGA5
    Sirion Biotech Customized lentivirus for stable overexpression of GOLGA5 
                         Customized lentivirus expression plasmids for stable overexpression of GOLGA5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GOLGA5
    OriGene qSTAR qPCR primer pairs in human, mouse for GOLGA5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GOLGA5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GOLGA5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GOLGA5

    Additional mRNA sequence: 

    AF085199.1 AJ132949.1 AK293077.1 AK303789.1 AY644768.1 BC010134.2 BC023021.1 BX248744.1 

    11 DOTS entries:

    DT.418802  DT.120754669  DT.100026359  DT.101981921  DT.100798232  DT.100688610  DT.100798234  DT.100798233 
    DT.100800338  DT.40122962  DT.80102031 

    24/212 AceView cDNA sequences (see all 212):

    NM_005113 BI793315 AA235507 AV650332 BM817966 CR608254 AI479708 CK725050 
    CA389169 AA402735 BQ218736 BU838407 AV681596 AA699342 AV651967 AV650230 
    AI346630 AA292442 BM458123 AA236693 AA127732 BX116039 AA886966 AA292491 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GOLGA5 expression in normal human tissues (normalized intensities)      GOLGA5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACAGGCTT
    GOLGA5 Expression
    About this image


    GOLGA5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Uterus (Reproductive System)    fully expand to see all 5 entries
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Epithelium (Uncategorized)    fully expand to see all 4 entries
             vagina ; squamous epithelial cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   

    See GOLGA5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GOLGA5

    SOURCE GeneReport for Unigene cluster: Hs.104320

    UniProtKB/Swiss-Prot: GOGA5_HUMAN, Q8TBA6
    Tissue specificity: Ubiquitous. Highly expressed in seminiferous tubules and Leydig cells in testis, and detected
    at much lower levels in the other tissues tested. Expression is very low or not detectable in spermatozoa

        SABiosciences Custom PCR Arrays for GOLGA5
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GOLGA5
    OriGene qSTAR qPCR primer pairs in human, mouse for GOLGA5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GOLGA5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GOLGA5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GOLGA5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOLGA5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GOLGA5 gene from 9/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Golga51 , 5 golgi autoantigen, golgin subfamily a, 51, 5 83.36(n)1
    84.32(a)1
      12 (51.51 cM)5
    272771  NM_013747.41  NP_038775.11 
     1024691345 
    chicken
    (Gallus gallus)
    Aves GOLGA51 golgin A5 74.12(n)
    76.41(a)
      423419  XM_421329.3  XP_421329.2 
    lizard
    (Anolis carolinensis)
    Reptilia GOLGA56
    golgin A5
    71(a)
    1 ↔ 1
    1(11220692-11245407)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.157672 Transcribed sequence with weak similarity to protein more 76.66(n)    BX708080.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd50h112 Danio rerio cDNA clone MGC66400 IMAGE5915039, complete more 73.4(n)    BC055639.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Golgin841 CG17785-PA 40.2(n)
    27.31(a)
      42905  NM_142993.2  NP_651250.2 
    worm
    (Caenorhabditis elegans)
    Secernentea T24B1.11 Protein T24B1.1 45.27(n)
    30.77(a)
      172527  NM_059736.3  NP_492137.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GC11 golgin candidate 1 40.94(n)
    27.18(a)
      816514  NM_001202627.1  NP_001189556.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g07444001 hypothetical protein 36.95(n)
    23.13(a)
      4326171  NM_001050760.1  NP_001044225.1 


    ENSEMBL Gene Tree for GOLGA5 (if available)
    TreeFam Gene Tree for GOLGA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GOLGA5 gene

    GOLGA5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GOLGA5
    PGOHUM00000235195


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1200 SNPs in GOLGA5 are shown (see all 1200)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs354825901,2
    C--73479780(+) TTTTTT/-AGCTT 1 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs354498071,2
    C--73483558(+) TCACC-/TTTTTT 1 -- int10--------
    rs49049951,2
    C,A,H--73486894(+) tttttC/Tttttg 1 -- int1 trp30--------
    rs1172742901,2
    C--74248712(+) ACCAAA/CCAAAC 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1145870341,2
    C,F--74248795(+) TACTCC/TGAAGC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1451755141,2
    --74248796(+) ACTCCA/GAAGCC 1 -- us2k10--------
    rs10185391,2
    C,F,O,A,H--74248805(-) AAGGGT/CACAGG 1 -- us2k119Minor allele frequency- C:0.22MN NS EA NA WA CSA 2497
    rs1848340121,2
    --74248974(+) TCACAC/TTGTCC 1 -- us2k10--------
    rs10185381,2
    C,F,A,H--74248977(-) ttgggT/Acagtg 1 -- us2k115Minor allele frequency- A:0.23NS EA NA WA CSA 740
    rs1491424341,2
    C--74248982(+) TCCCAA/TGTTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GOLGA5 (93260576 - 93306308 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GOLGA5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv819955CNV Loss19587683
    nsv522417CNV Gain19592680


    Human Gene Mutation Database (HGMD): GOLGA5
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GOLGA5
    DNA2.0 Custom Variant and Variant Library Synthesis for GOLGA5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606918   
    OMIM disorders: 188550  
    UniProtKB/Swiss-Prot: GOGA5_HUMAN, Q8TBA6
  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an
    irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm
    characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered
    with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry is involved in
    disease pathogenesis. A chromosomal aberration involving GOLGA5 is found in thyroid papillary carcinomas.
    Translocation t(10;14)(q11;q32) with RET. The translocation generates the RET/GOLGA5 (PTC5) oncogene which was
    found in 2 cases of PACT in children exposed to radioactive fallout after Chernobyl

  • 5 diseases for GOLGA5:    About MalaCards
    sigmoid colon cancer    oculocerebrorenal syndrome    papillary carcinoma    colon cancer
    thyroiditis

    2 diseases from the University of Copenhagen DISEASES database for GOLGA5:
    Sigmoid colon cancer     Oculocerebrorenal syndrome

    GOLGA5 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for GOLGA5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 9443391 (1)

    Genetic Association Database (GAD): GOLGA5

    Export disorders for GOLGA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GOLGA5 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with GOLGA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Detection of a novel type of Ret rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved Ret-fused gene RFG5. (PubMed id 9443391)1, 2, 3, 9 Klugbauer S.... Rabes H.M. (1998)
    2. Activation of the ret-II oncogene without a sequence encoding a transmembrane domain and transforming activity of two ret-II oncogene products differing in carboxy-termini due to alternative splicing. (PubMed id 2734021)1, 2, 3 Ishizaka Y.... Nahao M. (1989)
    3. Identification and characterization of golgin-84, a novel Golgi integral membrane protein with a cytoplasmic coiled-coil domain. (PubMed id 9915833)1, 2, 9 Bascom R.A.... Nussbaum R.L. (1999)
    4. The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation. (PubMed id 12538640)1, 2, 9 Diao A.... Lowe M. (2003)
    5. Golgin tethers define subpopulations of COPI vesicles. (PubMed id 15718469)1, 2, 9 Malsam J.... Warren G. (2005)
    6. The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. (PubMed id 15004235)1, 3, 9 Oka T....Krieger M. (2004)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    9. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9950 HGNC: 4428 AceView: GOLGA5 Ensembl:ENSG00000066455 euGenes: HUgn9950
    ECgene: GOLGA5 H-InvDB: GOLGA5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GOLGA5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GOLGA5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GOLGA5 gene:
    Search GeneIP for patents involving GOLGA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GOLGA5  
     OriGene qPCR primer pairs and template standards for GOLGA5   OriGene Protein Over-expression Lysate for GOLGA5  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GOLGA5  
     OriGene qSTAR qPCR primer pairs in human, mouse for GOLGA5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GOLGA5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GOLGA5   OriGene Custom Protein Services for GOLGA5  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GOLGA5
     QIAGEN SeqTarget long-range PCR primers for resequencing GOLGA5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GOLGA5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GOLGA5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GOLGA5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GOLGA5
     GenScript Custom Purified and Recombinant Proteins Services for GOLGA5 GenScript cDNA clones with any tag delivered in your preferred vector for GOLGA5
     GenScript Custom Assay Services for GOLGA5 GenScript Custom Superior Antibodies Services for GOLGA5
     GenScript Custom overexpressing Cell Line Services for GOLGA5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GOLGA5 promoter
     Search Chromatin IP Primers for GOLGA5
     RT2 qPCR Primer Assay in human, mouse, rat GOLGA5
     GNC Network for GOLGA5
     SABiosciences Custom PCR Arrays for GOLGA5
     Search Tocris compounds for GOLGA5 (GOGA5)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GOLGA5 antibodies
     GOLGA5 proteins
     GOLGA5 lysates
     Antibodies for GOLGA5
     See all of Abcam's Antibodies, Kits and Proteins for GOLGA5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for GOLGA5
     Antibodies for GOLGA5
     ELISAs for GOLGA5
     CLIAs for GOLGA5
     Search LifeMap BioReagents cell lines for GOLGA5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GOLGA5
     SwitchGear 3'UTR luciferase reporter plasmids for GOLGA5
     SwitchGear Promoter luciferase reporter plasmids for GOLGA5
     ThermoFisher Antibody for GOLGA5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GOLGA5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GOLGA5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GOLGA5
    Customized:
     lentivirus for stable overexpression of GOLGA5
     lentivirus expression plasmids for stable overexpression of GOLGA5
     adenovirus for overexpression of GOLGA5
     LSBio Antibodies in human, mouse, rat for GOLGA5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GOLGA5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4