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Aliases for GOLGA5 Gene

Aliases for GOLGA5 Gene

  • Golgin A5 2 3
  • RFG5 3 4 6
  • Cell Proliferation-Inducing Gene 31 Protein 3 4
  • Golgi Autoantigen, Golgin Subfamily A, 5 2 3
  • Golgi Integral Membrane Protein 5 2 3
  • RET-Fused Gene 5 Protein 3 4
  • Golgin-84 3 4
  • Golgin Subfamily A Member 5 3
  • Protein Ret-II 4
  • GOLIM5 3
  • Ret-II 3
  • RETII 4
  • PTC5 6

External Ids for GOLGA5 Gene

Summaries for GOLGA5 Gene

Entrez Gene Summary for GOLGA5 Gene

  • The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the ret proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5. A pseudogene of this gene is located on the short arm of chromosome 5. [provided by RefSeq, Jul 2013]

GeneCards Summary for GOLGA5 Gene

GOLGA5 (Golgin A5) is a Protein Coding gene. Diseases associated with GOLGA5 include oculocerebrorenal syndrome and thyroid carcinoma, papillary. GO annotations related to this gene include protein homodimerization activity and Rab GTPase binding.

UniProtKB/Swiss-Prot for GOLGA5 Gene

  • Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.

Gene Wiki entry for GOLGA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLGA5 Gene

Genomics for GOLGA5 Gene

Genomic Location for GOLGA5 Gene

Start:
92,794,231 bp from pter
End:
92,839,963 bp from pter
Size:
45,733 bases
Orientation:
Plus strand

Genomic View for GOLGA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GOLGA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA5 Gene

Regulatory Elements for GOLGA5 Gene

Proteins for GOLGA5 Gene

  • Protein details for GOLGA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBA6-GOGA5_HUMAN
    Recommended name:
    Golgin subfamily A member 5
    Protein Accession:
    Q8TBA6
    Secondary Accessions:
    • C9JRU1
    • O95287
    • Q03962
    • Q2TS49
    • Q9UQQ7

    Protein attributes for GOLGA5 Gene

    Size:
    731 amino acids
    Molecular mass:
    83024 Da
    Quaternary structure:
    • Homodimer. Interacts with RAB1A that has been activated by GTP-binding, and possibly also with OCRL1. Interacts with isoform CASP of CUX1.
    SequenceCaution:
    • Sequence=CAA33787.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. A chimeric cDNA originating from chromosomes 14 and 10.; Evidence={ECO:0000305};

    Alternative splice isoforms for GOLGA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOLGA5 Gene

Proteomics data for GOLGA5 Gene at MOPED

Post-translational modifications for GOLGA5 Gene

  • Highly phosphorylated during mitosis. Phosphorylation is barely detectable during interphase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GOLGA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GOLGA5 Gene

Domains for GOLGA5 Gene

Protein Domains for GOLGA5 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with GOLGA5: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GOLGA5 Gene

Function for GOLGA5 Gene

Molecular function for GOLGA5 Gene

GENATLAS Biochemistry: Golgi autoantigen,golgin-84,subfamily A,member 5,ubiquitously expressed,abundantly in testis,forming the RET-II oncogene when fused by its coiled coil domain to the RET tyrosine kinase domain
UniProtKB/Swiss-Prot Function: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.

Gene Ontology (GO) - Molecular Function for GOLGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0017137 Rab GTPase binding IDA 12538640
GO:0042803 protein homodimerization activity IPI 9915833
genes like me logo Genes that share ontologies with GOLGA5: view

miRNA for GOLGA5 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GOLGA5 Gene

Localization for GOLGA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLGA5 Gene

Golgi apparatus membrane; Single-pass type IV membrane protein. Note=Found throughout the Golgi, both on cisternae and, at higher abundance, on the tubulo-vesicular structures of the cis-Golgi network.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GOLGA5 Gene COMPARTMENTS Subcellular localization image for GOLGA5 gene
Compartment Confidence
golgi apparatus 5
nucleus 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GOLGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005801 cis-Golgi network IDA 12538640
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IDA 9915833
genes like me logo Genes that share ontologies with GOLGA5: view

Pathways for GOLGA5 Gene

SuperPathways for GOLGA5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GOLGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IMP 12538640
GO:0048193 Golgi vesicle transport IMP 12538640
genes like me logo Genes that share ontologies with GOLGA5: view

No data available for Pathways by source for GOLGA5 Gene

Compounds for GOLGA5 Gene

(1) HMDB Compounds for GOLGA5 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(1) Novoseek inferred chemical compound relationships for GOLGA5 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 15.7 1
genes like me logo Genes that share compounds with GOLGA5: view

Transcripts for GOLGA5 Gene

mRNA/cDNA for GOLGA5 Gene

Unigene Clusters for GOLGA5 Gene

Golgin A5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA5 Gene

No ASD Table

Relevant External Links for GOLGA5 Gene

GeneLoc Exon Structure for
GOLGA5
ECgene alternative splicing isoforms for
GOLGA5

Expression for GOLGA5 Gene

mRNA expression in normal human tissues for GOLGA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GOLGA5 Gene

SOURCE GeneReport for Unigene cluster for GOLGA5 Gene Hs.104320

mRNA Expression by UniProt/SwissProt for GOLGA5 Gene

Q8TBA6-GOGA5_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in seminiferous tubules and Leydig cells in testis, and detected at much lower levels in the other tissues tested. Expression is very low or not detectable in spermatozoa.
genes like me logo Genes that share expressions with GOLGA5: view

Orthologs for GOLGA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for GOLGA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOLGA5 36
  • 99.36 (n)
  • 99.45 (a)
GOLGA5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GOLGA5 36
  • 89.1 (n)
  • 89.47 (a)
GOLGA5 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GOLGA5 36
  • 89.32 (n)
  • 91.1 (a)
GOLGA5 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Golga5 36
  • 83.04 (n)
  • 84.32 (a)
Golga5 16
Golga5 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GOLGA5 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 62 (a)
OneToMany
-- 37
  • 73 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Golga5 36
  • 83.97 (n)
  • 84.89 (a)
chicken
(Gallus gallus)
Aves GOLGA5 36
  • 74.17 (n)
  • 76.54 (a)
GOLGA5 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GOLGA5 37
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia golga5 36
  • 69.16 (n)
  • 70.94 (a)
Str.15767 36
zebrafish
(Danio rerio)
Actinopterygii golga5 36
  • 59.99 (n)
  • 61.75 (a)
golga5 37
  • 57 (a)
OneToOne
wufd50h11 36
fruit fly
(Drosophila melanogaster)
Insecta Golgin84 37
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T24B1.1 36
  • 44.68 (n)
  • 30.05 (a)
T24B1.1 37
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4460 37
  • 34 (a)
OneToOne
Species with no ortholog for GOLGA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GOLGA5 Gene

ENSEMBL:
Gene Tree for GOLGA5 (if available)
TreeFam:
Gene Tree for GOLGA5 (if available)

Paralogs for GOLGA5 Gene

Pseudogenes.org Pseudogenes for GOLGA5 Gene

genes like me logo Genes that share paralogs with GOLGA5: view

No data available for Paralogs for GOLGA5 Gene

Variants for GOLGA5 Gene

Sequence variations from dbSNP and Humsavar for GOLGA5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs11707 -- 92,839,742(-) TACAG(A/T)TGGTC utr-variant-3-prime
rs743219 -- 92,812,318(+) TCTCC(A/G)TAGAT intron-variant
rs743220 -- 92,812,236(+) AAAAC(A/C)TGTCC intron-variant
rs927294 -- 92,813,404(-) TCAGG(A/C)AAGTT intron-variant
rs1016688 -- 92,793,086(-) TCGCC(C/T)GTTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GOLGA5 Gene

Variant ID Type Subtype PubMed ID
nsv819955 CNV Loss 19587683
nsv522417 CNV Gain 19592680

Relevant External Links for GOLGA5 Gene

HapMap Linkage Disequilibrium report
GOLGA5
Human Gene Mutation Database (HGMD)
GOLGA5

Disorders for GOLGA5 Gene

(1) OMIM Diseases for GOLGA5 Gene (606918)

UniProtKB/Swiss-Prot

GOGA5_HUMAN
  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving GOLGA5 is found in thyroid papillary carcinomas. Translocation t(10;14)(q11;q32) with RET. The translocation generates the RET/GOLGA5 (PTC5) oncogene which was found in 2 cases of PACT in children exposed to radioactive fallout after Chernobyl.

(2) University of Copenhagen DISEASES for GOLGA5 Gene

(1) Novoseek inferred disease relationships for GOLGA5 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for GOLGA5

Genetic Association Database (GAD)
GOLGA5
genes like me logo Genes that share disorders with GOLGA5: view

Publications for GOLGA5 Gene

  1. Detection of a novel type of Ret rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved Ret-fused gene RFG5. (PMID: 9443391) Klugbauer S. … Rabes H.M. (Cancer Res. 1998) 2 3 4 23
  2. Identification and characterization of golgin-84, a novel Golgi integral membrane protein with a cytoplasmic coiled-coil domain. (PMID: 9915833) Bascom R.A. … Nussbaum R.L. (J. Biol. Chem. 1999) 3 4 23
  3. The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. (PMID: 15004235) Oka T. … Krieger M. (Mol. Biol. Cell 2004) 2 3 23
  4. Golgin tethers define subpopulations of COPI vesicles. (PMID: 15718469) Malsam J. … Warren G. (Science 2005) 3 4 23
  5. The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation. (PMID: 12538640) Diao A. … Lowe M. (J. Cell Biol. 2003) 3 4 23

Products for GOLGA5 Gene

Sources for GOLGA5 Gene

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