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Aliases for GOLGA4 Gene

Aliases for GOLGA4 Gene

  • Golgin A4 2 3
  • Golgi Autoantigen, Golgin Subfamily A, 4 2 3
  • Trans-Golgi P230 3 4
  • 256 KDa Golgin 3 4
  • Protein 72.1 3 4
  • Golgin-245 3 4
  • Centrosome-Related Protein F46 3
  • Golgin Subfamily A Member 4 3
  • 72.1 Protein 3
  • MU-RMS-40.18 3
  • Golgin 245 2
  • Golgin-240 3
  • CRPF46 3
  • GCP2 3
  • GOLG 3
  • P230 3

External Ids for GOLGA4 Gene

Summaries for GOLGA4 Gene

Entrez Gene Summary for GOLGA4 Gene

  • The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]

GeneCards Summary for GOLGA4 Gene

GOLGA4 (Golgin A4) is a Protein Coding gene. GO annotations related to this gene include GTPase binding.

UniProtKB/Swiss-Prot for GOLGA4 Gene

  • May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1.

Gene Wiki entry for GOLGA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLGA4 Gene

Genomics for GOLGA4 Gene

Genomic Location for GOLGA4 Gene

Start:
37,243,177 bp from pter
End:
37,366,879 bp from pter
Size:
123,703 bases
Orientation:
Plus strand

Genomic View for GOLGA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GOLGA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA4 Gene

Regulatory Elements for GOLGA4 Gene

Proteins for GOLGA4 Gene

  • Protein details for GOLGA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13439-GOGA4_HUMAN
    Recommended name:
    Golgin subfamily A member 4
    Protein Accession:
    Q13439
    Secondary Accessions:
    • F8W8Q7
    • Q13270
    • Q13654
    • Q14436
    • Q59EW8

    Protein attributes for GOLGA4 Gene

    Size:
    2230 amino acids
    Molecular mass:
    261140 Da
    Quaternary structure:
    • Homodimer. Interacts with GTP bound ARL1. Interacts with MACF1.
    Miscellaneous:
    • Antibodies against GOLGA4 are present in sera from patients with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex
    SequenceCaution:
    • Sequence=BAD92930.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA58041.1; Type=Frameshift; Positions=2153; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GOLGA4 Gene

    Alternative splice isoforms for GOLGA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOLGA4 Gene

Proteomics data for GOLGA4 Gene at MOPED

Post-translational modifications for GOLGA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GOLGA4 Gene

Domains for GOLGA4 Gene

Protein Domains for GOLGA4 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

GOGA4_HUMAN
Domain:
  • Extended rod-like protein with coiled-coil domains:
    • Q13439
  • Contains 1 GRIP domain.:
    • Q13439
genes like me logo Genes that share domains with GOLGA4: view

No data available for Gene Families for GOLGA4 Gene

Function for GOLGA4 Gene

Molecular function for GOLGA4 Gene

UniProtKB/Swiss-Prot Function: May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1.

Gene Ontology (GO) - Molecular Function for GOLGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0005515 protein binding IPI 15265687
GO:0051020 GTPase binding IPI 14580338
genes like me logo Genes that share ontologies with GOLGA4: view

miRNA for GOLGA4 Gene

miRTarBase miRNAs that target GOLGA4

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GOLGA4 Gene

Localization for GOLGA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLGA4 Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GOLGA4 Gene COMPARTMENTS Subcellular localization image for GOLGA4 gene
Compartment Confidence
golgi apparatus 5
nucleus 3
cytosol 2
endosome 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GOLGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with GOLGA4: view

Pathways for GOLGA4 Gene

SuperPathways for GOLGA4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GOLGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000042 protein targeting to Golgi IEA --
GO:0016192 vesicle-mediated transport TAS 8626529
GO:0043001 Golgi to plasma membrane protein transport IMP 22705394
GO:0045773 positive regulation of axon extension IDA 22705394
genes like me logo Genes that share ontologies with GOLGA4: view

No data available for Pathways by source for GOLGA4 Gene

Transcripts for GOLGA4 Gene

Unigene Clusters for GOLGA4 Gene

Golgin A4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3:
SP4: - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - - -
SP6: - - - -
SP7: - - - - - - - - -
SP8:
SP9:
SP10: - -
SP11:
SP12: - -
SP13:

ExUns: 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b
SP1: - - - - -
SP2:
SP3: - - -
SP4: - - - - - - - - - - - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for GOLGA4 Gene

GeneLoc Exon Structure for
GOLGA4
ECgene alternative splicing isoforms for
GOLGA4

Expression for GOLGA4 Gene

mRNA expression in normal human tissues for GOLGA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GOLGA4 Gene

This gene is overexpressed in Muscle - Skeletal (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GOLGA4 Gene

SOURCE GeneReport for Unigene cluster for GOLGA4 Gene Hs.344151

genes like me logo Genes that share expressions with GOLGA4: view

Orthologs for GOLGA4 Gene

This gene was present in the common ancestor of animals.

Orthologs for GOLGA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOLGA4 36
  • 99.38 (n)
  • 99.02 (a)
GOLGA4 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GOLGA4 36
  • 87.51 (n)
  • 83.86 (a)
GOLGA4 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GOLGA4 36
  • 88.33 (n)
  • 84.18 (a)
GOLGA4 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Golga4 36
  • 75.95 (n)
  • 71.7 (a)
Golga4 16
Golga4 37
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GOLGA4 37
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 46 (a)
OneToMany
-- 37
  • 58 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Golga4 36
  • 75.27 (n)
  • 71.31 (a)
chicken
(Gallus gallus)
Aves GOLGA4 36
  • 67.15 (n)
  • 61.34 (a)
GOLGA4 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GOLGA4 37
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia golga4 36
  • 59.46 (n)
  • 48.99 (a)
zebrafish
(Danio rerio)
Actinopterygii golga4 36
  • 52.99 (n)
  • 43.87 (a)
golga4 37
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3493 37
  • 24 (a)
OneToOne
CG3493 38
  • 20 (a)
worm
(Caenorhabditis elegans)
Secernentea hcp-1 38
  • 20 (a)
C02F12.7 38
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 23 (a)
OneToMany
-- 37
  • 29 (a)
OneToMany
Species with no ortholog for GOLGA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GOLGA4 Gene

ENSEMBL:
Gene Tree for GOLGA4 (if available)
TreeFam:
Gene Tree for GOLGA4 (if available)

Paralogs for GOLGA4 Gene

Pseudogenes.org Pseudogenes for GOLGA4 Gene

genes like me logo Genes that share paralogs with GOLGA4: view

No data available for Paralogs for GOLGA4 Gene

Variants for GOLGA4 Gene

Sequence variations from dbSNP and Humsavar for GOLGA4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs3116 -- 37,366,695(-) CAACA(A/G)TCACA utr-variant-3-prime
rs336597 -- 37,248,331(-) CCACT(A/G)CCTAA intron-variant
rs883523 -- 37,269,601(-) TGAAG(C/T)TTTAT intron-variant
rs1040073 -- 37,267,041(-) ACTTT(A/G)AGAGA intron-variant
rs1143514 -- 37,273,887(+) gcttg(A/G)ggcca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GOLGA4 Gene

Variant ID Type Subtype PubMed ID
nsv834664 CNV Loss 17160897
nsv834665 CNV Loss 17160897
nsv876704 CNV Gain 21882294
esv269812 CNV Insertion 20981092

Relevant External Links for GOLGA4 Gene

HapMap Linkage Disequilibrium report
GOLGA4

Disorders for GOLGA4 Gene

No disorders were found for GOLGA4 Gene.

No data available for UniProtKB/Swiss-Prot for GOLGA4 Gene

Publications for GOLGA4 Gene

  1. Molecular characterization of trans-Golgi p230: a human peripheral membrane protein encoded by a gene on chromosome 6p12-22 contains extensive coiled-coil alpha-helical domains and a granin motif. (PMID: 8626529) Erlich R. … Toh B.-H. (J. Biol. Chem. 1996) 2 3 4 23
  2. ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. (PMID: 11303027) Van Valkenburgh H. … Kahn R.A. (J. Biol. Chem. 2001) 3 4 23
  3. Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus. (PMID: 14580338) Panic B. … Munro S. (Mol. Cell 2003) 3 4 23
  4. Structural basis for recruitment of GRIP domain golgin-245 by small GTPase Arl1. (PMID: 14718928) Wu M. … Song H. (Nat. Struct. Mol. Biol. 2004) 3 4 23
  5. Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery. (PMID: 15265687) Kakinuma T. … Toh B.H. (Exp. Cell Res. 2004) 3 4 23

Products for GOLGA4 Gene

Sources for GOLGA4 Gene

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