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Aliases for GOLGA4 Gene

Aliases for GOLGA4 Gene

  • Golgin A4 2 3 5
  • Golgi Autoantigen, Golgin Subfamily A, 4 2 3
  • Trans-Golgi P230 3 4
  • 256 KDa Golgin 3 4
  • Protein 72.1 3 4
  • Golgin-245 3 4
  • Centrosome-Related Protein F46 3
  • Golgin Subfamily A Member 4 3
  • 72.1 Protein 3
  • MU-RMS-40.18 3
  • Golgin 245 2
  • Golgin-240 3
  • CRPF46 3
  • GCP2 3
  • GOLG 3
  • P230 3

External Ids for GOLGA4 Gene

Previous GeneCards Identifiers for GOLGA4 Gene

  • GC03P036667
  • GC03P036556
  • GC03P037097
  • GC03P037245
  • GC03P037259
  • GC03P037225
  • GC03P037284

Summaries for GOLGA4 Gene

Entrez Gene Summary for GOLGA4 Gene

  • The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]

GeneCards Summary for GOLGA4 Gene

GOLGA4 (Golgin A4) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Retrograde transport at the Trans-Golgi-Network. GO annotations related to this gene include nucleotide binding and GTPase binding.

UniProtKB/Swiss-Prot for GOLGA4 Gene

  • May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1.

Gene Wiki entry for GOLGA4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLGA4 Gene

Genomics for GOLGA4 Gene

Regulatory Elements for GOLGA4 Gene

Enhancers for GOLGA4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G037227 1.3 ENCODE dbSUPER 18.6 -13.8 -13801 2.8 HDGF FOXA2 MLX ARNT ARID4B DMAP1 YY1 SLC30A9 ZNF766 SP5 LRRFIP2 GOLGA4 RPS16P4 RPL29P11 MLH1 ENSG00000271653
GH03G037243 1.4 ENCODE dbSUPER 11.2 +0.5 541 3.3 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 LRRFIP2 GOLGA4 RPS16P4 ENSG00000272334 ENSG00000270194
GH03G037452 1.6 FANTOM5 Ensembl ENCODE dbSUPER 8.8 +212.9 212882 7.5 BCOR CTCF RNF2 SUZ12 TAF1 NR2F1 ZMYM3 MAX REST RAD21 ITGA9 LRRFIP2 GOLGA4 GC03M037573
GH03G037289 1.2 Ensembl ENCODE 10.7 +47.9 47922 2.8 HDAC1 ATF1 PKNOX1 TBL1XR1 CHAMP1 TCF12 GATA2 ELK1 FOS ZBTB11 LRRFIP2 GOLGA4 TCEA1P2 RNA5SP129
GH03G037216 1.4 FANTOM5 ENCODE dbSUPER 7.6 -25.3 -25339 3.3 ELF3 TBP CBX3 ARID4B DMAP1 RAD21 ZNF48 RARA MIXL1 THAP11 LRRFIP2 RPS16P4 GOLGA4 ENSG00000271653
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GOLGA4 on UCSC Golden Path with GeneCards custom track

Promoters for GOLGA4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000150862 723 2601 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for GOLGA4 Gene

Chromosome:
3
Start:
37,243,177 bp from pter
End:
37,366,879 bp from pter
Size:
123,703 bases
Orientation:
Plus strand

Genomic View for GOLGA4 Gene

Genes around GOLGA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLGA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLGA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA4 Gene

Proteins for GOLGA4 Gene

  • Protein details for GOLGA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13439-GOGA4_HUMAN
    Recommended name:
    Golgin subfamily A member 4
    Protein Accession:
    Q13439
    Secondary Accessions:
    • F8W8Q7
    • Q13270
    • Q13654
    • Q14436
    • Q59EW8

    Protein attributes for GOLGA4 Gene

    Size:
    2230 amino acids
    Molecular mass:
    261140 Da
    Quaternary structure:
    • Homodimer. Interacts with GTP bound ARL1. Interacts with MACF1.
    Miscellaneous:
    • Antibodies against GOLGA4 are present in sera from patients with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex.
    SequenceCaution:
    • Sequence=BAD92930.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA58041.1; Type=Frameshift; Positions=2153; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GOLGA4 Gene

    Alternative splice isoforms for GOLGA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOLGA4 Gene

Post-translational modifications for GOLGA4 Gene

  • Glycosylation at isoforms=3, 4, 5585 and isoforms=3, 4, 51612
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GOLGA4 Gene

Domains & Families for GOLGA4 Gene

Protein Domains for GOLGA4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GOLGA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13439

UniProtKB/Swiss-Prot:

GOGA4_HUMAN :
  • Extended rod-like protein with coiled-coil domains.
Domain:
  • Extended rod-like protein with coiled-coil domains.
genes like me logo Genes that share domains with GOLGA4: view

No data available for Gene Families for GOLGA4 Gene

Function for GOLGA4 Gene

Molecular function for GOLGA4 Gene

UniProtKB/Swiss-Prot Function:
May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1.

Gene Ontology (GO) - Molecular Function for GOLGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15265687
GO:0051020 GTPase binding IPI 14580338
genes like me logo Genes that share ontologies with GOLGA4: view
genes like me logo Genes that share phenotypes with GOLGA4: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLGA4 Gene

Localization for GOLGA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLGA4 Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLGA4 gene
Compartment Confidence
extracellular 5
cytosol 5
golgi apparatus 5
nucleus 4
plasma membrane 2
endosome 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GOLGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IDA,IEA 15265687
GO:0005794 Golgi apparatus IDA 15265687
GO:0005802 trans-Golgi network TAS 1400343
GO:0005829 cytosol TAS,IDA --
genes like me logo Genes that share ontologies with GOLGA4: view

Pathways & Interactions for GOLGA4 Gene

genes like me logo Genes that share pathways with GOLGA4: view

Gene Ontology (GO) - Biological Process for GOLGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000042 protein targeting to Golgi IEA --
GO:0016192 vesicle-mediated transport TAS 8626529
GO:0043001 Golgi to plasma membrane protein transport IMP 22705394
GO:0045773 positive regulation of axon extension IDA 22705394
genes like me logo Genes that share ontologies with GOLGA4: view

No data available for SIGNOR curated interactions for GOLGA4 Gene

Transcripts for GOLGA4 Gene

Unigene Clusters for GOLGA4 Gene

Golgin A4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3:
SP4: - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - - -
SP6: - - - -
SP7: - - - - - - - - -
SP8:
SP9:
SP10: - -
SP11:
SP12: - -
SP13:

ExUns: 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b
SP1: - - - - -
SP2:
SP3: - - -
SP4: - - - - - - - - - - - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for GOLGA4 Gene

GeneLoc Exon Structure for
GOLGA4
ECgene alternative splicing isoforms for
GOLGA4

Expression for GOLGA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GOLGA4 Gene

mRNA differential expression in normal tissues according to GTEx for GOLGA4 Gene

This gene is overexpressed in Muscle - Skeletal (x4.7).

Protein differential expression in normal tissues from HIPED for GOLGA4 Gene

This gene is overexpressed in Heart (25.6), Salivary gland (7.6), and Stomach (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GOLGA4 Gene



Protein tissue co-expression partners for GOLGA4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GOLGA4 Gene:

GOLGA4

SOURCE GeneReport for Unigene cluster for GOLGA4 Gene:

Hs.344151

Evidence on tissue expression from TISSUES for GOLGA4 Gene

  • Liver(4.5)
  • Stomach(4.4)
  • Nervous system(4.4)
  • Lung(3)
  • Heart(2.3)
  • Pancreas(2.3)
  • Intestine(2.2)
  • Kidney(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with GOLGA4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLGA4 Gene

Orthologs for GOLGA4 Gene

This gene was present in the common ancestor of animals.

Orthologs for GOLGA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOLGA4 34 35
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia GOLGA4 34 35
  • 88.33 (n)
cow
(Bos Taurus)
Mammalia GOLGA4 34 35
  • 87.51 (n)
mouse
(Mus musculus)
Mammalia Golga4 34 16 35
  • 75.95 (n)
rat
(Rattus norvegicus)
Mammalia Golga4 34
  • 75.27 (n)
oppossum
(Monodelphis domestica)
Mammalia GOLGA4 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 58 (a)
OneToMany
-- 35
  • 46 (a)
OneToMany
chicken
(Gallus gallus)
Aves GOLGA4 34 35
  • 67.15 (n)
lizard
(Anolis carolinensis)
Reptilia GOLGA4 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia golga4 34
  • 59.46 (n)
zebrafish
(Danio rerio)
Actinopterygii golga4 34 35
  • 52.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3493 36 35
  • 20 (a)
worm
(Caenorhabditis elegans)
Secernentea C02F12.7 36
  • 21 (a)
hcp-1 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToMany
-- 35
  • 23 (a)
OneToMany
Species where no ortholog for GOLGA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GOLGA4 Gene

ENSEMBL:
Gene Tree for GOLGA4 (if available)
TreeFam:
Gene Tree for GOLGA4 (if available)

Paralogs for GOLGA4 Gene

Pseudogenes.org Pseudogenes for GOLGA4 Gene

genes like me logo Genes that share paralogs with GOLGA4: view

No data available for Paralogs for GOLGA4 Gene

Variants for GOLGA4 Gene

Sequence variations from dbSNP and Humsavar for GOLGA4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs11924014 untested 37,329,075(+) AAAAG(A/T)TATGA reference, missense
rs1000010252 -- 37,347,452(+) TTACA(A/G)AGTGA intron-variant
rs1000015574 -- 37,262,334(+) AACCC(A/C)ATCTC intron-variant
rs1000029355 -- 37,241,449(+) CCGAT(A/T)AGCTT upstream-variant-2KB
rs1000051578 -- 37,262,511(+) AAAAA(A/G)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GOLGA4 Gene

Variant ID Type Subtype PubMed ID
esv3360632 CNV insertion 20981092
esv3595885 CNV gain 21293372
esv3595886 CNV gain 21293372
esv3595887 CNV gain 21293372
nsv1003117 CNV gain 25217958
nsv834664 CNV loss 17160897
nsv834665 CNV loss 17160897

Variation tolerance for GOLGA4 Gene

Residual Variation Intolerance Score: 49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.25; 88.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GOLGA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLGA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLGA4 Gene

Disorders for GOLGA4 Gene

Relevant External Links for GOLGA4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GOLGA4

No disorders were found for GOLGA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOLGA4 Gene

Publications for GOLGA4 Gene

  1. Molecular characterization of trans-Golgi p230: a human peripheral membrane protein encoded by a gene on chromosome 6p12-22 contains extensive coiled-coil alpha-helical domains and a granin motif. (PMID: 8626529) Erlich R. … Toh B.-H. (J. Biol. Chem. 1996) 2 3 4 22 64
  2. Structural basis for recruitment of GRIP domain golgin-245 by small GTPase Arl1. (PMID: 14718928) Wu M. … Song H. (Nat. Struct. Mol. Biol. 2004) 3 4 22 64
  3. Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery. (PMID: 15265687) Kakinuma T. … Toh B.H. (Exp. Cell Res. 2004) 3 4 22 64
  4. Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus. (PMID: 14580338) Panic B. … Munro S. (Mol. Cell 2003) 3 4 22 64
  5. ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. (PMID: 11303027) Van Valkenburgh H. … Kahn R.A. (J. Biol. Chem. 2001) 3 4 22 64

Products for GOLGA4 Gene

Sources for GOLGA4 Gene

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