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Aliases for GOLGA3 Gene

Aliases for GOLGA3 Gene

  • Golgin A3 2 3 5
  • Golgi Complex-Associated Protein Of 170 KDa 3 4
  • Golgi Autoantigen, Golgin Subfamily A, 3 2 3
  • SY2/SY10 Protein 2 3
  • Golgin-160 3 4
  • GCP170 3 4
  • Golgi Complex-Associated Protein Of 170 KD 2
  • Golgi Membrane Associated Protein 3
  • Golgi Peripheral Membrane Protein 3
  • Golgin Subfamily A Member 3 3
  • Male Enhanced Antigen-2 3
  • Golgin-165 3
  • MEA-2 3

External Ids for GOLGA3 Gene

Previous GeneCards Identifiers for GOLGA3 Gene

  • GC12M130854
  • GC12M132899
  • GC12M132973
  • GC12M131584
  • GC12M131955
  • GC12M131855
  • GC12M133345
  • GC12M130123

Summaries for GOLGA3 Gene

Entrez Gene Summary for GOLGA3 Gene

  • The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins which are localized to the Golgi. Its encoded protein has been postulated to play a role in nuclear transport and Golgi apparatus localization. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Feb 2010]

GeneCards Summary for GOLGA3 Gene

GOLGA3 (Golgin A3) is a Protein Coding gene. Diseases associated with GOLGA3 include Smallpox. GO annotations related to this gene include transporter activity. An important paralog of this gene is ENSG00000283396.

UniProtKB/Swiss-Prot for GOLGA3 Gene

  • Golgi auto-antigen; probably involved in maintaining Golgi structure.

Gene Wiki entry for GOLGA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLGA3 Gene

Genomics for GOLGA3 Gene

Regulatory Elements for GOLGA3 Gene

Enhancers for GOLGA3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F131864 0.5 ENCODE 63.2 +963.7 963738 1.2 ATF1 PKNOX1 ZNF133 SIN3A YBX1 PLRG1 RAD21 ZNF155 ZNF302 SMARCC2 EP400 GOLGA3 SFSWAP DDX51 ENSG00000255933 FBRSL1 NOC4L EP400NL RNU6-1017P MMP17
GH12F132487 1.6 FANTOM5 Ensembl ENCODE 28.8 +329.8 329769 23.9 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF26 EP400NL ZNF891 FBRSL1 EP400 ZNF10 GOLGA3 NOC4L ENSG00000256875 ZNF84
GH12F132600 0.8 FANTOM5 Ensembl ENCODE 22.8 +226.7 226679 4.8 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CBX5 ZNF143 POLE ZNF140 GOLGA3 EP400 ZNF10 P2RX2 ZNF26 PXMP2 ENSG00000256632 DDX51
GH12F132597 1 Ensembl ENCODE 21 +230.8 230804 1.8 HDGF ARNT ZNF493 ZNF133 YBX1 GLI4 ZNF48 ZNF2 ZNF121 GLIS2 ZNF140 ZNF84 ENSG00000255933 EP400 ZNF26 ENSG00000250790 ZNF605 DDX51 GOLGA3 SFSWAP
GH12F131859 1.7 FANTOM5 Ensembl ENCODE 18.3 +967.0 966998 4.7 PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 EP400 SFSWAP GOLGA3 DDX51 MMP17 RNU6-1017P ULK1 ENSG00000256955
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GOLGA3 on UCSC Golden Path with GeneCards custom track

Promoters for GOLGA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000174971 318 2000 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for GOLGA3 Gene

Chromosome:
12
Start:
132,768,909 bp from pter
End:
132,829,118 bp from pter
Size:
60,210 bases
Orientation:
Minus strand

Genomic View for GOLGA3 Gene

Genes around GOLGA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLGA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLGA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA3 Gene

Proteins for GOLGA3 Gene

  • Protein details for GOLGA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08378-GOGA3_HUMAN
    Recommended name:
    Golgin subfamily A member 3
    Protein Accession:
    Q08378
    Secondary Accessions:
    • A5PKX6
    • O43241
    • Q6P9C7
    • Q86XW3
    • Q8TDA9
    • Q8WZA3

    Protein attributes for GOLGA3 Gene

    Size:
    1498 amino acids
    Molecular mass:
    167355 Da
    Quaternary structure:
    • Homodimer. Interacts with GOLGA7. Isoform 1 interacts with GOPC while isoform 3 does not.
    SequenceCaution:
    • Sequence=AAA35921.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH60826.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA23661.1; Type=Frameshift; Positions=1378; Evidence={ECO:0000305};

    Alternative splice isoforms for GOLGA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOLGA3 Gene

Post-translational modifications for GOLGA3 Gene

No data available for DME Specific Peptides for GOLGA3 Gene

Domains & Families for GOLGA3 Gene

Protein Domains for GOLGA3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GOLGA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q08378

UniProtKB/Swiss-Prot:

GOGA3_HUMAN :
  • Extended rod-like protein with coiled-coil domains.
Domain:
  • Extended rod-like protein with coiled-coil domains.
genes like me logo Genes that share domains with GOLGA3: view

No data available for Gene Families for GOLGA3 Gene

Function for GOLGA3 Gene

Molecular function for GOLGA3 Gene

UniProtKB/Swiss-Prot Function:
Golgi auto-antigen; probably involved in maintaining Golgi structure.

Gene Ontology (GO) - Molecular Function for GOLGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity NAS 8315394
GO:0005515 protein binding IPI 14522980
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with GOLGA3: view
genes like me logo Genes that share phenotypes with GOLGA3: view

Animal Models for GOLGA3 Gene

MGI Knock Outs for GOLGA3:

Animal Model Products

miRNA for GOLGA3 Gene

miRTarBase miRNAs that target GOLGA3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GOLGA3 Gene

Localization for GOLGA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLGA3 Gene

Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GOLGA3 Gene COMPARTMENTS Subcellular localization image for GOLGA3 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 5

Gene Ontology (GO) - Cellular Components for GOLGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS 9295333
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with GOLGA3: view

Pathways & Interactions for GOLGA3 Gene

SuperPathways for GOLGA3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GOLGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006891 intra-Golgi vesicle-mediated transport NAS 8315394
GO:0007283 spermatogenesis IEA --
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with GOLGA3: view

No data available for Pathways by source and SIGNOR curated interactions for GOLGA3 Gene

Transcripts for GOLGA3 Gene

Unigene Clusters for GOLGA3 Gene

Golgin A3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: -
SP2:
SP3: - - -
SP4:
SP5: -
SP6: - - - -
SP7:
SP8:

ExUns: 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b · 25c ^ 26 ^ 27a · 27b · 27c ^ 28 ^ 29
SP1: - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for GOLGA3 Gene

GeneLoc Exon Structure for
GOLGA3
ECgene alternative splicing isoforms for
GOLGA3

Expression for GOLGA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GOLGA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GOLGA3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.3), Lymph node (11.4), and Salivary gland (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GOLGA3 Gene



Protein tissue co-expression partners for GOLGA3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GOLGA3 Gene:

GOLGA3

SOURCE GeneReport for Unigene cluster for GOLGA3 Gene:

Hs.507333

mRNA Expression by UniProt/SwissProt for GOLGA3 Gene:

Q08378-GOGA3_HUMAN
Tissue specificity: Expressed in all tissues tested. Expressed in liver, testis, lung, heart, salivary gland and kidney.
genes like me logo Genes that share expression patterns with GOLGA3: view

Primer Products

No data available for mRNA differential expression in normal tissues for GOLGA3 Gene

Orthologs for GOLGA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GOLGA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOLGA3 34 35
  • 99.31 (n)
cow
(Bos Taurus)
Mammalia GOLGA3 34 35
  • 84.33 (n)
dog
(Canis familiaris)
Mammalia GOLGA3 34 35
  • 82.87 (n)
mouse
(Mus musculus)
Mammalia Golga3 34 16 35
  • 79.63 (n)
rat
(Rattus norvegicus)
Mammalia Golga3 34
  • 79.38 (n)
oppossum
(Monodelphis domestica)
Mammalia GOLGA3 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GOLGA3 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves GOLGA3 34 35
  • 71.1 (n)
lizard
(Anolis carolinensis)
Reptilia GOLGA3 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia golga3 34
  • 66.62 (n)
zebrafish
(Danio rerio)
Actinopterygii golga3 34 35
  • 65.84 (n)
Species where no ortholog for GOLGA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GOLGA3 Gene

ENSEMBL:
Gene Tree for GOLGA3 (if available)
TreeFam:
Gene Tree for GOLGA3 (if available)

Paralogs for GOLGA3 Gene

Paralogs for GOLGA3 Gene

genes like me logo Genes that share paralogs with GOLGA3: view

Variants for GOLGA3 Gene

Sequence variations from dbSNP and Humsavar for GOLGA3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1009320 -- 132,784,378(+) GTGCC(A/G)GCAGG intron-variant
rs1009321 -- 132,784,638(+) CACAC(A/G)TGCTC intron-variant
rs1043124 -- 132,769,585(-) TTTCC(A/G)TGGTA utr-variant-3-prime
rs10431484 -- 132,806,938(+) TCTAG(C/G)AAATA intron-variant
rs10431485 -- 132,806,976(+) GCCCA(C/T)GCACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GOLGA3 Gene

Variant ID Type Subtype PubMed ID
dgv318e214 CNV loss 21293372
esv1041062 CNV deletion 17803354
esv1099700 CNV deletion 17803354
esv1379006 CNV deletion 17803354
esv1610869 CNV insertion 17803354
esv22525 CNV loss 19812545
esv25686 CNV loss 19812545
esv2661448 CNV deletion 23128226
esv2667719 CNV deletion 23128226
esv2673163 CNV deletion 23128226
esv2674717 CNV deletion 23128226
esv2747040 CNV deletion 23290073
esv3326208 CNV duplication 20981092
esv3550097 CNV deletion 23714750
esv3550098 CNV deletion 23714750
esv3550100 CNV deletion 23714750
esv3580555 CNV loss 25503493
esv3631312 CNV loss 21293372
esv3631315 CNV loss 21293372
esv3631316 CNV loss 21293372
esv3631317 CNV gain 21293372
esv3631320 CNV gain 21293372
esv994357 CNV deletion 20482838
nsv1037074 CNV gain 25217958
nsv1071080 CNV deletion 25765185
nsv1120273 CNV tandem duplication 24896259
nsv1124853 CNV deletion 24896259
nsv1130673 CNV deletion 24896259
nsv1138190 CNV deletion 24896259
nsv1139775 CNV deletion 24896259
nsv1143584 CNV deletion 24896259
nsv1147106 CNV deletion 26484159
nsv455811 CNV loss 19166990
nsv455812 CNV loss 19166990
nsv52999 CNV insertion 16902084
nsv53567 CNV deletion 16902084
nsv561129 CNV loss 21841781
nsv561130 CNV loss 21841781
nsv561131 CNV gain 21841781
nsv561132 CNV loss 21841781
nsv561133 CNV loss 21841781
nsv561134 CNV loss 21841781
nsv952513 CNV deletion 24416366
nsv958702 CNV deletion 24416366
nsv975543 CNV duplication 23825009

Variation tolerance for GOLGA3 Gene

Residual Variation Intolerance Score: 29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.23; 95.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GOLGA3 Gene

Human Gene Mutation Database (HGMD)
GOLGA3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLGA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLGA3 Gene

Disorders for GOLGA3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GOLGA3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
smallpox
  • ordinary smallpox
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GOLGA3

Genetic Association Database (GAD)
GOLGA3
Human Genome Epidemiology (HuGE) Navigator
GOLGA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GOLGA3
genes like me logo Genes that share disorders with GOLGA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GOLGA3 Gene

Publications for GOLGA3 Gene

  1. Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex. (PMID: 8315394) Fritzler M.J. … Chan E.K.L. (J. Exp. Med. 1993) 2 3 4 22 64
  2. Caspase-resistant Golgin-160 disrupts apoptosis induced by secretory pathway stress and ligation of death receptors. (PMID: 15829563) Maag R.S. … Machamer C.E. (Mol. Biol. Cell 2005) 2 3 22 64
  3. The NH2-terminal domain of Golgin-160 contains both Golgi and nuclear targeting information. (PMID: 12130652) Hicks S.W. … Machamer C.E. (J. Biol. Chem. 2002) 3 4 22 64
  4. Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis. (PMID: 10791974) Mancini M. … Rosen A. (J. Cell Biol. 2000) 3 4 22 64
  5. Identification of a common autoantigenic epitope of protein disulfide isomerase, golgin-160 and voltage-gated potassium channel in type 1 diabetes. (PMID: 20170975) Fierabracci A. … Saura F. (Diabetes Res. Clin. Pract. 2010) 3 22 64

Products for GOLGA3 Gene

Sources for GOLGA3 Gene

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