Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GOLGA3 Gene

Aliases for GOLGA3 Gene

  • Golgin A3 2 3 5
  • Golgi Complex-Associated Protein Of 170 KDa 3 4
  • Golgi Autoantigen, Golgin Subfamily A, 3 2 3
  • SY2/SY10 Protein 2 3
  • Golgin-160 3 4
  • GCP170 3 4
  • Golgi Complex-Associated Protein Of 170 KD 2
  • Golgi Membrane Associated Protein 3
  • Golgi Peripheral Membrane Protein 3
  • Male Enhanced Antigen-2 3
  • Golgin-165 3
  • MEA-2 3

External Ids for GOLGA3 Gene

Previous GeneCards Identifiers for GOLGA3 Gene

  • GC12M130854
  • GC12M132899
  • GC12M132973
  • GC12M131584
  • GC12M131955
  • GC12M131855
  • GC12M133345
  • GC12M130123

Summaries for GOLGA3 Gene

Entrez Gene Summary for GOLGA3 Gene

  • The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins which are localized to the Golgi. Its encoded protein has been postulated to play a role in nuclear transport and Golgi apparatus localization. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Feb 2010]

GeneCards Summary for GOLGA3 Gene

GOLGA3 (Golgin A3) is a Protein Coding gene. Diseases associated with GOLGA3 include smallpox. GO annotations related to this gene include transporter activity.

UniProtKB/Swiss-Prot for GOLGA3 Gene

  • Golgi auto-antigen; probably involved in maintaining Golgi structure.

Gene Wiki entry for GOLGA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLGA3 Gene

Genomics for GOLGA3 Gene

Regulatory Elements for GOLGA3 Gene

Promoters for GOLGA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GOLGA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for GOLGA3 Gene

Chromosome:
12
Start:
132,768,909 bp from pter
End:
132,829,118 bp from pter
Size:
60,210 bases
Orientation:
Minus strand

Genomic View for GOLGA3 Gene

Genes around GOLGA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLGA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLGA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA3 Gene

Proteins for GOLGA3 Gene

  • Protein details for GOLGA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08378-GOGA3_HUMAN
    Recommended name:
    Golgin subfamily A member 3
    Protein Accession:
    Q08378
    Secondary Accessions:
    • A5PKX6
    • O43241
    • Q6P9C7
    • Q86XW3
    • Q8TDA9
    • Q8WZA3

    Protein attributes for GOLGA3 Gene

    Size:
    1498 amino acids
    Molecular mass:
    167355 Da
    Quaternary structure:
    • Homodimer. Interacts with GOLGA7. Isoform 1 interacts with GOPC while isoform 3 does not.
    SequenceCaution:
    • Sequence=AAA35921.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH60826.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA23661.1; Type=Frameshift; Positions=1378; Evidence={ECO:0000305};

    Alternative splice isoforms for GOLGA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOLGA3 Gene

Proteomics data for GOLGA3 Gene at MOPED

Post-translational modifications for GOLGA3 Gene

Other Protein References for GOLGA3 Gene

Antibody Products

No data available for DME Specific Peptides for GOLGA3 Gene

Domains & Families for GOLGA3 Gene

Protein Domains for GOLGA3 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for GOLGA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q08378

UniProtKB/Swiss-Prot:

GOGA3_HUMAN :
  • Extended rod-like protein with coiled-coil domains.
Domain:
  • Extended rod-like protein with coiled-coil domains.
genes like me logo Genes that share domains with GOLGA3: view

No data available for Gene Families for GOLGA3 Gene

Function for GOLGA3 Gene

Molecular function for GOLGA3 Gene

UniProtKB/Swiss-Prot Function:
Golgi auto-antigen; probably involved in maintaining Golgi structure.
genes like me logo Genes that share phenotypes with GOLGA3: view

Animal Models for GOLGA3 Gene

MGI Knock Outs for GOLGA3:

Animal Model Products

miRNA for GOLGA3 Gene

miRTarBase miRNAs that target GOLGA3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GOLGA3 Gene

Localization for GOLGA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLGA3 Gene

Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GOLGA3 Gene COMPARTMENTS Subcellular localization image for GOLGA3 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 5

Gene Ontology (GO) - Cellular Components for GOLGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS 9295333
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA 14522980
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with GOLGA3: view

Pathways & Interactions for GOLGA3 Gene

SuperPathways for GOLGA3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GOLGA3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GOLGA3 Gene

Drugs & Compounds for GOLGA3 Gene

No Compound Related Data Available

Transcripts for GOLGA3 Gene

Unigene Clusters for GOLGA3 Gene

Golgin A3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: -
SP2:
SP3: - - -
SP4:
SP5: -
SP6: - - - -
SP7:
SP8:

ExUns: 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b · 25c ^ 26 ^ 27a · 27b · 27c ^ 28 ^ 29
SP1: - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for GOLGA3 Gene

GeneLoc Exon Structure for
GOLGA3
ECgene alternative splicing isoforms for
GOLGA3

Expression for GOLGA3 Gene

mRNA expression in normal human tissues for GOLGA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GOLGA3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.3), Lymph node (11.4), and Salivary gland (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GOLGA3 Gene



SOURCE GeneReport for Unigene cluster for GOLGA3 Gene Hs.507333

mRNA Expression by UniProt/SwissProt for GOLGA3 Gene

Q08378-GOGA3_HUMAN
Tissue specificity: Expressed in all tissues tested. Expressed in liver, testis, lung, heart, salivary gland and kidney.
genes like me logo Genes that share expression patterns with GOLGA3: view

Protein tissue co-expression partners for GOLGA3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for GOLGA3 Gene

Orthologs for GOLGA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GOLGA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOLGA3 35
  • 99.31 (n)
  • 99.33 (a)
GOLGA3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GOLGA3 36
  • 84 (a)
OneToOne
GOLGA3 35
  • 84.33 (n)
  • 84.6 (a)
dog
(Canis familiaris)
Mammalia GOLGA3 35
  • 82.87 (n)
  • 81.72 (a)
GOLGA3 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Golga3 16
Golga3 36
  • 81 (a)
OneToOne
Golga3 35
  • 79.63 (n)
  • 81.9 (a)
oppossum
(Monodelphis domestica)
Mammalia GOLGA3 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GOLGA3 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Golga3 35
  • 79.38 (n)
  • 81.83 (a)
chicken
(Gallus gallus)
Aves GOLGA3 35
  • 71.1 (n)
  • 73.53 (a)
GOLGA3 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GOLGA3 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia golga3 35
  • 66.62 (n)
  • 68.33 (a)
zebrafish
(Danio rerio)
Actinopterygii golga3 36
  • 59 (a)
OneToOne
golga3 35
  • 65.84 (n)
  • 63.37 (a)
Species with no ortholog for GOLGA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GOLGA3 Gene

ENSEMBL:
Gene Tree for GOLGA3 (if available)
TreeFam:
Gene Tree for GOLGA3 (if available)

Paralogs for GOLGA3 Gene

No data available for Paralogs for GOLGA3 Gene

Variants for GOLGA3 Gene

Sequence variations from dbSNP and Humsavar for GOLGA3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2291256 - 132,816,737(-) GAACG(A/G)GCCAA intron-variant, reference, missense
rs2291260 - 132,780,826(-) GGAGA(A/G)GGAGA reference, missense
rs3741486 - 132,808,278(+) GAGCC(A/G)GGACA reference, missense
rs3703 -- 132,825,669(-) CTTCC(A/C)GTTTC intron-variant, upstream-variant-2KB
rs900444 -- 132,777,884(+) GTGAA(C/T)GCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GOLGA3 Gene

Variant ID Type Subtype PubMed ID
dgv1534n71 CNV Loss 21882294
dgv1544n71 CNV Loss 21882294
dgv1545n71 CNV Loss 21882294
nsv455811 CNV Loss 19166990
esv2747040 CNV Deletion 23290073
esv22525 CNV Loss 19812545
esv994357 CNV Deletion 20482838
esv1041062 CNV Deletion 17803354
esv2674717 CNV Deletion 23128226
esv1379006 CNV Deletion 17803354
esv2667719 CNV Deletion 23128226
esv1610869 CNV Insertion 17803354
nsv52999 CNV Insertion 16902084
esv2673163 CNV Deletion 23128226
esv2661448 CNV Deletion 23128226
nsv53567 CNV Loss 16902084
nsv455812 CNV Loss 19166990
esv25686 CNV Loss 19812545
esv1099700 CNV Deletion 17803354

Variation tolerance for GOLGA3 Gene

Residual Variation Intolerance Score: 29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.23; 95.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GOLGA3 Gene

HapMap Linkage Disequilibrium report
GOLGA3
Human Gene Mutation Database (HGMD)
GOLGA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLGA3 Gene

Disorders for GOLGA3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GOLGA3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
smallpox
  • ordinary smallpox
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GOLGA3

Genetic Association Database (GAD)
GOLGA3
Human Genome Epidemiology (HuGE) Navigator
GOLGA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GOLGA3
genes like me logo Genes that share disorders with GOLGA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GOLGA3 Gene

Publications for GOLGA3 Gene

  1. Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex. (PMID: 8315394) Fritzler M.J. … Chan E.K.L. (J. Exp. Med. 1993) 2 3 4 23 67
  2. Caspase-resistant Golgin-160 disrupts apoptosis induced by secretory pathway stress and ligation of death receptors. (PMID: 15829563) Maag R.S. … Machamer C.E. (Mol. Biol. Cell 2005) 2 3 23
  3. Identification of a common autoantigenic epitope of protein disulfide isomerase, golgin-160 and voltage-gated potassium channel in type 1 diabetes. (PMID: 20170975) Fierabracci A. … Saura F. (Diabetes Res. Clin. Pract. 2010) 3 23
  4. Identification of a redox-sensitive cysteine in GCP60 that regulates its interaction with golgin-160. (PMID: 17711851) Sbodio J.I. … Machamer C.E. (J. Biol. Chem. 2007) 3 23
  5. Golgin-160 promotes cell surface expression of the beta-1 adrenergic receptor. (PMID: 17118120) Hicks S.W. … Machamer C.E. (Traffic 2006) 3 23

Products for GOLGA3 Gene

Sources for GOLGA3 Gene

Back to Top

Content