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Aliases for GOLGA2 Gene

Aliases for GOLGA2 Gene

  • Golgin A2 2 3 5
  • Golgi Autoantigen, Golgin Subfamily A, 2 2 3
  • 130 KDa Cis-Golgi Matrix Protein 3 4
  • Golgi Matrix Protein GM130 2 3
  • GM130 Autoantigen 3 4
  • SY11 Protein 2 3
  • Golgin-95 3 4
  • GM130 3 4

External Ids for GOLGA2 Gene

Previous GeneCards Identifiers for GOLGA2 Gene

  • GC09M122134
  • GC09M122665
  • GC09M124471
  • GC09M126394
  • GC09M128097
  • GC09M130057
  • GC09M131018
  • GC09M100631

Summaries for GOLGA2 Gene

Entrez Gene Summary for GOLGA2 Gene

  • The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Feb 2010]

GeneCards Summary for GOLGA2 Gene

GOLGA2 (Golgin A2) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Transport to the Golgi and subsequent modification. GO annotations related to this gene include protein kinase binding and syntaxin binding. An important paralog of this gene is GOLGA8G.

UniProtKB/Swiss-Prot for GOLGA2 Gene

  • Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401).

Gene Wiki entry for GOLGA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLGA2 Gene

Genomics for GOLGA2 Gene

Regulatory Elements for GOLGA2 Gene

Enhancers for GOLGA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GOLGA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GOLGA2 Gene

Chromosome:
9
Start:
128,255,829 bp from pter
End:
128,276,007 bp from pter
Size:
20,179 bases
Orientation:
Minus strand

Genomic View for GOLGA2 Gene

Genes around GOLGA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLGA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLGA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA2 Gene

Proteins for GOLGA2 Gene

  • Protein details for GOLGA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08379-GOGA2_HUMAN
    Recommended name:
    Golgin subfamily A member 2
    Protein Accession:
    Q08379
    Secondary Accessions:
    • Q6GRM9
    • Q9BRB0
    • Q9NYF9

    Protein attributes for GOLGA2 Gene

    Size:
    1002 amino acids
    Molecular mass:
    113086 Da
    Quaternary structure:
    • Part of a larger oligomeric complex (By similarity). Interacts with p115/USO1 (By similarity). Interacts with RAB1B that has been activated by GTP-binding (PubMed:11306556). Interacts with GORASP1/GRASP65 (PubMed:16489344, PubMed:18045989). Interacts with ZFPL1 (PubMed:18323775). Interacts with AKAP450/AKAP9; leading to recruit AKAP450/AKAP9 to the cis-Golgi (PubMed:19242490).
    SequenceCaution:
    • Sequence=AAH69268.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAP35912.1; Type=Miscellaneous discrepancy; Note=Sequence differs from that shown after position 826 due to an internal deletion.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GOLGA2 Gene

    Alternative splice isoforms for GOLGA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOLGA2 Gene

Proteomics data for GOLGA2 Gene at MOPED

Post-translational modifications for GOLGA2 Gene

  • Cleaved by caspases at the onset of apoptosis.
  • Methylation by PRMT5 is required for Golgi ribbon formation. While dimethylation at Arg-30 and Arg-35 are confirmed in vivo, it is unclear whether Arg-18 is methylated in vivo.
  • Phosphorylated at Ser-37 by CDK1 at the onset of mitosis, inhibiting the interaction with p115/USO1 and triggering Golgi disassembly (PubMed:20421892, PubMed:26165940). Phosphorylated at Ser-37 in prophase as the Golgi complex starts to break down, and remains phosphorylated during further breakdown and partitioning of the Golgi fragments in metaphase and anaphase. In telophase, GM130 is dephosphorylated by PP2A as the Golgi fragments start to reassemble (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GOLGA2 Gene

Antibody Products

  • R&D Systems Antibodies for GOLGA2 (GM130/GOLGA2)
  • Cell Signaling Technology (CST) Antibodies for GOLGA2 (GM130)

No data available for DME Specific Peptides for GOLGA2 Gene

Domains & Families for GOLGA2 Gene

Protein Domains for GOLGA2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GOLGA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q08379

UniProtKB/Swiss-Prot:

GOGA2_HUMAN :
  • The nuclear localization signal (cNLS) mediates interaction with importin-alpha, recruiting importin-alpha to the Golgi membrane and liberating TPX2.
  • Belongs to the GOLGA2 family.
Domain:
  • The nuclear localization signal (cNLS) mediates interaction with importin-alpha, recruiting importin-alpha to the Golgi membrane and liberating TPX2.
Family:
  • Belongs to the GOLGA2 family.
genes like me logo Genes that share domains with GOLGA2: view

No data available for Gene Families for GOLGA2 Gene

Function for GOLGA2 Gene

Molecular function for GOLGA2 Gene

UniProtKB/Swiss-Prot Function:
Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401).

Gene Ontology (GO) - Molecular Function for GOLGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061676 importin-alpha family protein binding ISS --
genes like me logo Genes that share ontologies with GOLGA2: view
genes like me logo Genes that share phenotypes with GOLGA2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLGA2 Gene

Localization for GOLGA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLGA2 Gene

Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, spindle pole. Note=Peripheral membrane protein associated with cis-Golgi stacks (By similarity). Associates with the mitotic spindle during mitosis (PubMed:26165940). {ECO:0000250 UniProtKB:Q62839, ECO:0000269 PubMed:26165940}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GOLGA2 Gene COMPARTMENTS Subcellular localization image for GOLGA2 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
nucleus 5
cytosol 2
endoplasmic reticulum 2
endosome 2
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for GOLGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005634 nucleus IDA --
GO:0005794 Golgi apparatus IEA,IDA 15229288
GO:0005874 microtubule IEA --
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane TAS --
genes like me logo Genes that share ontologies with GOLGA2: view

Pathways & Interactions for GOLGA2 Gene

genes like me logo Genes that share pathways with GOLGA2: view

Pathways by source for GOLGA2 Gene

1 Cell Signaling Technology pathway for GOLGA2 Gene
1 BioSystems pathway for GOLGA2 Gene

SIGNOR curated interactions for GOLGA2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for GOLGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007020 microtubule nucleation IMP 19242490
GO:0007092 activation of APC-Cdc20 complex activity TAS --
GO:0008356 asymmetric cell division ISS --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0032091 negative regulation of protein binding IDA 18167358
genes like me logo Genes that share ontologies with GOLGA2: view

Drugs & Compounds for GOLGA2 Gene

(1) Drugs for GOLGA2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GOLGA2: view

Transcripts for GOLGA2 Gene

Unigene Clusters for GOLGA2 Gene

Golgin A2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c ^ 20 ^
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

ExUns: 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for GOLGA2 Gene

GeneLoc Exon Structure for
GOLGA2
ECgene alternative splicing isoforms for
GOLGA2

Expression for GOLGA2 Gene

mRNA expression in normal human tissues for GOLGA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GOLGA2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.1), Nasal epithelium (8.8), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GOLGA2 Gene



SOURCE GeneReport for Unigene cluster for GOLGA2 Gene Hs.155827

genes like me logo Genes that share expression patterns with GOLGA2: view

Protein tissue co-expression partners for GOLGA2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GOLGA2 Gene

Orthologs for GOLGA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GOLGA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GOLGA2 35
  • 80.1 (n)
  • 76.02 (a)
-- 36
  • 75 (a)
OneToMany
dog
(Canis familiaris)
Mammalia GOLGA2 35
  • 81 (n)
  • 76.04 (a)
-- 36
  • 73 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Golga2 35
  • 79.29 (n)
  • 76.35 (a)
Golga2 16
Golga2 36
  • 73 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia GOLGA2 35
  • 99.57 (n)
  • 99.3 (a)
GOLGA2 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Golga2 35
  • 79.45 (n)
  • 76.81 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
chicken
(Gallus gallus)
Aves GOLGA2 35
  • 64.83 (n)
  • 61.25 (a)
-- 36
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.28684 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492442 35
  • 62.54 (n)
  • 58.38 (a)
zebrafish
(Danio rerio)
Actinopterygii golga2 35
  • 59.56 (n)
  • 52 (a)
golga2 36
  • 46 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011337 35
  • 46 (n)
  • 30.35 (a)
Species with no ortholog for GOLGA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GOLGA2 Gene

ENSEMBL:
Gene Tree for GOLGA2 (if available)
TreeFam:
Gene Tree for GOLGA2 (if available)

Paralogs for GOLGA2 Gene

genes like me logo Genes that share paralogs with GOLGA2: view

Variants for GOLGA2 Gene

Sequence variations from dbSNP and Humsavar for GOLGA2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs2240961 - 128,257,459(-) ATGGC(A/G)GATTC reference, missense
rs1046074 -- 128,255,904(-) CGGGG(A/G)TGGGG utr-variant-3-prime
rs7855784 -- 128,263,563(+) caggc(C/G)cccgc intron-variant
rs113132247 -- 128,263,829(+) ATTAC(A/G)GCACC intron-variant
rs113564350 -- 128,262,548(+) ATGGG(G/T)CTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GOLGA2 Gene

Variant ID Type Subtype PubMed ID
nsv893891 CNV Loss 21882294
dgv8294n71 CNV Loss 21882294
nsv893896 CNV Loss 21882294
nsv831728 CNV Loss 17160897

Variation tolerance for GOLGA2 Gene

Residual Variation Intolerance Score: 70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.48; 94.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GOLGA2 Gene

HapMap Linkage Disequilibrium report
GOLGA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLGA2 Gene

Disorders for GOLGA2 Gene

Relevant External Links for GOLGA2

Human Genome Epidemiology (HuGE) Navigator
GOLGA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GOLGA2

No disorders were found for GOLGA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOLGA2 Gene

Publications for GOLGA2 Gene

  1. Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex. (PMID: 8315394) Fritzler M.J. … Chan E.K.L. (J. Exp. Med. 1993) 2 3 4 23 67
  2. Emerging new roles of GM130, a cis-Golgi matrix protein, in higher order cell functions. (PMID: 20197635) Nakamura N. (J. Pharmacol. Sci. 2010) 3 23
  3. CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation. (PMID: 20332113) Fidalgo M. … Zalvide J. (J. Cell Sci. 2010) 3 23
  4. Microtubule nucleation at the cis-side of the Golgi apparatus requires AKAP450 and GM130. (PMID: 19242490) Rivero S. … Rios R.M. (EMBO J. 2009) 3 23
  5. Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner. (PMID: 18167358) Diao A. … Lowe M. (J. Biol. Chem. 2008) 3 23

Products for GOLGA2 Gene

Sources for GOLGA2 Gene

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