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GOLGA2 Gene

protein-coding   GIFtS: 60
GCID: GC09M131018

Golgin A2

(Previous names: golgi autoantigen, golgin subfamily a, 2)
  See GOLGA2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Golgin A21 2     GM1302 3
Golgi Autoantigen, Golgin Subfamily A, 21 2     GM130 Autoantigen2 3
Golgi Matrix Protein GM1301 2     Golgin Subfamily A Member 22
SY11 Protein1 2     golgin-952
130 KDa Cis-Golgi Matrix Protein2 3     Golgin-953

External Ids:    HGNC: 44251   Entrez Gene: 28012   Ensembl: ENSG000001671107   OMIM: 6025805   UniProtKB: Q083793   

Export aliases for GOLGA2 gene to outside databases

Previous GC identifers: GC09M122134 GC09M122665 GC09M124471 GC09M126394 GC09M128097 GC09M130057 GC09M100631


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GOLGA2 Gene:
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory
pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and
microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis.
This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein has been
postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively
spliced transcript variants of this gene have been described, but the full-length nature of these variants has
not been determined. (provided by RefSeq, Feb 2010)

GeneCards Summary for GOLGA2 Gene:
GOLGA2 (golgin A2) is a protein-coding gene. Diseases associated with GOLGA2 include mucopolysaccharidosis iii. An important paralog of this gene is GOLGA8N.

UniProtKB/Swiss-Prot: GOGA2_HUMAN, Q08379
Function: Golgi auto-antigen; probably involved in maintaining cis-Golgi structure

Gene Wiki entry for GOLGA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GOLGA2 gene promoter:
         Bach1   Egr-1   FOXD3   MyoD   Tal-1beta   C/EBPalpha   HFH-1   Chx10   ITF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGOLGA2 promoter sequence
   Search Chromatin IP Primers for GOLGA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GOLGA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.13

GOLGA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GOLGA2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M131018:  view genomic region     (about GC identifiers)

Start:
131,018,108 bp from pter      End:
131,038,274 bp from pter
Size:
20,167 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GOGA2_HUMAN, Q08379 (See protein sequence)
Recommended Name: Golgin subfamily A member 2  
Size: 1002 amino acids; 113086 Da
Subunit: Part of a larger oligomeric complex. Interacts with p115 (By similarity). Interacts with RAB1B that has
been activated by GTP-binding. Interacts with GORASP1/GRASP65 and ZFPL1
Sequence caution: Sequence=AAH69268.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAP35912.1; Type=Miscellaneous discrepancy; Note=Sequence differs from that shown after position 826 due
to an internal deletion;
Secondary accessions: Q6GRM9 Q9BRB0 Q9NYF9
Alternative splicing: 2 isoforms:  Q08379-1   Q08379-2   

Explore the universe of human proteins at neXtProt for GOLGA2: NX_Q08379

Explore proteomics data for GOLGA2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GOLGA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004477.3  
    ENSEMBL proteins: 
     ENSP00000416097   ENSP00000476265   ENSP00000409271   ENSP00000411598   ENSP00000473603  
    Reactome Protein details: Q08379

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR024858 Golgin_A

    Graphical View of Domain Structure for InterPro Entry Q08379

    ProtoNet protein and cluster: Q08379

    UniProtKB/Swiss-Prot: GOGA2_HUMAN, Q08379
    Domain: Extended rod-like protein with coiled-coil domains
    Similarity: Belongs to the GOLGA2 family


    Find genes that share domains with GOLGA2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GOGA2_HUMAN, Q08379
    Function: Golgi auto-antigen; probably involved in maintaining cis-Golgi structure

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15037601
    GO:0051082unfolded protein binding ----
         
    Find genes that share ontologies with GOLGA2           About GenesLikeMe


    Animal Models:
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    hsa-miR-548p hsa-miR-300 hsa-miR-605 hsa-miR-381 hsa-miR-944 hsa-miR-486-3p hsa-miR-3667-3p hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidGOLGA2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GOGA2_HUMAN, Q08379: Golgi apparatus, Golgi stack membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    nucleus3
    cytosol2
    endoplasmic reticulum1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus IDA--
    GO:0005801cis-Golgi network IDA18166528
    GO:0005874microtubule ----
    GO:0032580Golgi cisterna membrane IEA--

    Find genes that share ontologies with GOLGA2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GOLGA2 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    2RNA Polymerase I Promoter Opening
    Mitotic Prophase0.56
    Golgi Cisternae Pericentriolar Stack Reorganization0.00
    3PLK1 signaling events
    PLK1 signaling events
    4Cytoskeletal Signaling
    Cytoskeletal Signaling


    Find genes that share SuperPaths with GOLGA2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for GOLGA2
        Cytoskeletal Signaling

    1 BioSystems Pathway for GOLGA2
        PLK1 signaling events

    1 Reactome Pathway for GOLGA2
        Golgi Cisternae Pericentriolar Stack Reorganization


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GOLGA2
    Interactions:

        GeneGlobe Interaction Network for GOLGA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GOLGA2 (Q083791, 2, 3 ENSP000004160974) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKAP9Q999961, 2, 3, ENSP000003485734EBI-618309,EBI-1048311 MINT-7263737 MINT-7263700 MINT-7263725 I2D: score=1 STRING: ENSP00000348573
    TRIM29Q141342, 3, ENSP000003431294MINT-67616 I2D: score=6 STRING: ENSP00000343129
    GORASP2Q9H8Y82, 3, ENSP000002341604MINT-8256525 I2D: score=4 STRING: ENSP00000234160
    STK25O005061, 3, ENSP000003257484EBI-618309,EBI-618295 I2D: score=4 STRING: ENSP00000325748
    TUBGCP4Q9UGJ12, 3, ENSP000002603834MINT-66840 I2D: score=4 STRING: ENSP00000260383
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007021tubulin complex assembly ----
    GO:0050772positive regulation of axonogenesis ----
    GO:0051645Golgi localization ----

    Find genes that share ontologies with GOLGA2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GOLGA2 (GOGA2)

    1 HMDB Compound for GOLGA2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GOLGA2 gene: 
    NM_004486.4  

    Unigene Cluster for GOLGA2:

    Golgin A2
    Hs.155827  [show with all ESTs]
    Unigene Representative Sequence: BC069268
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000421699(uc004buh.3 uc011maw.2 uc010mxw.3) ENST00000609374
    ENST00000462089 ENST00000496221 ENST00000486411 ENST00000461031 ENST00000470630
    ENST00000450617(uc004bul.1) ENST00000490257 ENST00000468488 ENST00000458730(uc004bum.1)
    ENST00000490628
    miRNA
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    hsa-miR-548p hsa-miR-300 hsa-miR-605 hsa-miR-381 hsa-miR-944 hsa-miR-486-3p hsa-miR-3667-3p hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidGOLGA2 3' UTR sequence
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    Additional mRNA sequence: 

    AF248953.1 AY823636.1 BC006381.2 BC014188.2 BC069268.1 BT007248.1 L06147.1 

    19 DOTS entries:

    DT.455884  DT.100813063  DT.454596  DT.97816039  DT.70104965  DT.91744880  DT.102845572  DT.100691705 
    DT.75182209  DT.91953766  DT.95069991  DT.95069995  DT.40110037  DT.121166397  DT.95299669  DT.95319534 
    DT.100645394  DT.101986512  DT.91861308 

    Selected AceView cDNA sequences (see all 255):

    BE277001 BX114693 BU539221 T28414 BI053780 AI870965 BF594068 N93579 
    AA770590 AI498996 AA854541 BQ018396 BQ931522 AW299956 AI400357 AI420169 
    AF248953 BF594761 NM_004486 BQ020735 BI711206 BC014188 AL134991 AI570444 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA2 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c ^ 20 ^
    SP1:                                                                          -                                                                                 
    SP2:                                                                          -                                                                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for GOLGA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GOLGA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGAGGAGGT
    GOLGA2 Expression
    About this image


    GOLGA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    GOLGA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GOLGA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.155827
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GOLGA2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Golga21 , 5 golgi autoantigen, golgin subfamily a, 21, 5 79.29(n)1
    76.35(a)1
      2 (22.09 cM)5
    994121  NM_133852.21  NP_598613.21 
     322873845 
    chicken
    (Gallus gallus)
    Aves GOLGA21 golgi autoantigen, golgin subfamily a, 2 64.83(n)
    61.25(a)
      427766  XM_004945821.1  XP_004945878.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    55(a)
    1 → many
    GL343763.1(29332-55251)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.286842 Xenopus laevis transcribed sequence with weak similarity more 77.35(n)    BU915647.1 
    zebrafish
    (Danio rerio)
    Actinopterygii golga21 golgi autoantigen, golgin subfamily a, 2 59.56(n)
    52(a)
      565431  NM_001127334.1  NP_001120806.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0113371 AgaP_AGAP011337 46(n)
    30.35(a)
      1270601  XM_309313.4  XP_309313.4 


    ENSEMBL Gene Tree for GOLGA2 (if available)
    TreeFam Gene Tree for GOLGA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GOLGA2 gene
    GOLGA8N2  ENSG000002594552  GOLGA6L202  GOLGA8Q2  GOLGA8G2  GOLGA8O2  GOLGA6L22  GOLGA8F2  
    GOLGA8I2  GOLGA6C2  GOLGA6L62  GOLGA6L12  GOLGA8R2  GOLGA6L192  GOLGA6B2  GOLGA8S2  
    GOLGA6L92  GOLGA8B2  GOLGA6A2  GOLGA8A2  GOLGA8K2  GOLGA8T2  GOLGA6L102  GOLGA8J2  
    GOLGA6L182  GOLGA8M2  GOLGA6L42  GOLGA6D2  GOLGA8H2  
    Selected SIMAP similar genes for GOLGA2 using alignment to 5 protein entries:     GOGA2_HUMAN (see all proteins) (see all similar genes):
    DKFZp686K0319    DKFZp564E0216    GOLGA8K    GOLGA8T    GOLGA6L1    GOLGA2LY
    GOLGA6L2    GOLGA6B    GOLGA6A    GOLGA6C    GOLGA2P5    LOC283767
    GOLGA8M    LOC643699    GOLGA8H    GOLGA8Q    GOLGA8S    GOLGA8A

    Find genes that share paralogs with GOLGA2           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for GOLGA2 (see all 33)
    PGOHUM00000258461 PGOHUM00000262873 PGOHUM00000262898 PGOHUM00000262899 PGOHUM00000262900


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GOLGA2 (see all 476)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1388979501,2
    --131018171(+) AGGGCA/GCCACG 1 -- ut310--------
    rs1925743141,2
    --131018211(+) ATGCTA/TTCAAT 1 -- ut310--------
    rs1420205971,2
    --131018262(+) CCCCAC/TGTGCC 1 -- ut310--------
    rs771687441,2
    F--131018542(+) TTAAAT/CAACAA 1 -- ut311Minor allele frequency- C:0.01NA 120
    rs1856515941,2
    --131018568(+) AATTTA/GAGGAG 1 -- ut310--------
    rs47341,2
    C,F,A,H--131018639(-) TAGCAA/CATAAG 1 -- ut3130Minor allele frequency- C:0.19MN EA NA NS WA 4596
    rs20062801,2
    C,A--131018683(-) CATGTG/CCCTGC 1 -- ut317Minor allele frequency- C:0.11NA EA WA 610
    rs30513111,2
    C--131018793(-) aaaaa-/A/AA  
            
    TTATG
    2 -- ut31 trp30--------
    rs596506271,2
    C--131018807(+) TTTTT-/T/TT  
            
    GAGAC
    2 -- ut310--------
    rs120008181,2
    C,F,H--131018828(+) tctgtC/Tgccca 1 -- ut31 ese31Minor allele frequency- T:0.50NA 4

    HapMap Linkage Disequilibrium report for GOLGA2 (131018108 - 131038274 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GOLGA2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831728CNV Loss17160897
    dgv8294n71CNV Loss21882294
    nsv893896CNV Loss21882294
    nsv893891CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GOLGA2
    DNA2.0 Custom Variant and Variant Library Synthesis for GOLGA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602580    OMIM disorders: --

    1 disease for GOLGA2:    
    About MalaCards
    mucopolysaccharidosis iii

    1 disease from the University of Copenhagen DISEASES database for GOLGA2:
    Mucopolysaccharidosis III

    Find genes that share disorders with GOLGA2           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: GOLGA2 (1 document)

    Export disorders for GOLGA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GOLGA2 gene, integrated from 10 sources (see all 103):
    (articles sorted by number of sources associating them with GOLGA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex. (PubMed id 8315394)1, 2, 3, 9 Fritzler M.J.... Chan E.K.L. (J. Exp. Med. 1993)
    2. The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b. (PubMed id 11306556)1, 2, 9 Weide T....Barnekow A. (EMBO Rep. 2001)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Interaction with GM130 during HERG ion channel trafficking. Disruption by type 2 congenital long QT syndrome mutations. Human Ether-A -go-go-Related Gene. (PubMed id 12270925)1, 9 Roti E.C....Robertson G.A. (J. Biol. Chem. 2002)
    7. Characterization of a cis-Golgi matrix protein, GM130. (PubMed id 8557739)1, 9 Nakamura N....Warren G. (J. Cell Biol. 1995)
    8. Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner. (PubMed id 18167358)1, 9 Diao A....Lowe M. (J. Biol. Chem. 2008)
    9. Emerging new roles of GM130, a cis-Golgi matrix protein, in higher order cell functions. (PubMed id 20197635)1, 9 Nakamura N. (J. Pharmacol. Sci. 2010)
    10. Binding relationships of membrane tethering components. The giantin N terminus and the GM130 N terminus compete for binding to the p115 C terminus. (PubMed id 10744704)1, 9 Linstedt A.D....Sztul E. (J. Biol. Chem. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2801 HGNC: 4425 AceView: GOLGA2 Ensembl:ENSG00000167110 euGenes: HUgn2801
    ECgene: GOLGA2 H-InvDB: GOLGA2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GOLGA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GOLGA2 gene:
    Search GeneIP for patents involving GOLGA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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