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GNS Gene

protein-coding GIFtS: 62

GC12M063393

glucosamine (N-acetyl)-6-sulfatase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.1.6.14 ^³
G6S ^², ³, ⁵
Glucosamine-6-sulfatase ^³
MGC21274 ^²
N-acetylglucosamine-6-sulfatase ^²
glucosamine-6-sulfatase ^²

Descriptions
glucosamine (N-acetyl)-6-sulfatase ^²

External Ids
HGNC: 4422¹
Entrez Gene: 2799²
UniProtKB: P15586³
Ensembl: ENSG00000135677⁷

Search outside databases for aliases for GNS gene

Previous GC identifers: GC12M064570 GC12M065075 GC12M064823 GC12M063396

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GNS:

The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism

of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the

accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type

IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four

subtypes of Sanfilippo syndrome. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GNS gene

Entrez Gene cytogenetic band: 12q14 Ensembl cytogenetic band: 12q14.3 HGNC cytogenetic band: 12q14

GNS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M063393: (about GC identifiers)

Start:	63,393,489 bp from pter
End:	63,439,479 bp from pter
Size:	45,991 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_029419.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GNS_HUMAN, P15586 (See protein sequence)

Recommended Name: N-acetylglucosamine-6-sulfatase precursor

Size: 552 amino acids; 62082 Da

Cofactor: Binds 1 calcium ion per subunit (By similarity)

Subcellular location: Lysosome

Secondary accessions: Q53F05

Post-translational modifications:

The form A (78 kDa) is processed by internal peptidase cleavage to a 32 kDa N-terminal species

(form B) and a 48 kDa C-terminal species¹

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine

residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity

(By similarity)¹

REFSEQ proteins: NP_002067.1

ENSEMBL proteins:

ENSP00000258145

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for GNS (Glucosamine (N-acetyl)-6-Sulfatase/GNS)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GNS)
	Human Recombinant Proteins from Abnova (GNS)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005764	lysosome	IEA	--

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Antibodies for GNS:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for GNS
	R&D Systems Antibodies for GNS (Glucosamine (N-acetyl)-6-Sulfatase/GNS)
	Antibodies from Abcam (GNS), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GNS)
	Novus Biologicals Antibodies for GNS

Assays for GNS:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P15586

ProtoNet protein and cluster: P15586

1 Blocks protein family: IPB000917 Sulfatase

UniProtKB/Swiss-Prot: GNS_HUMAN, P15586

Similarity: Belongs to the sulfatase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GNS)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002076

Applied Biosystems Silencer® siRNAs for GNS

Sigma-Aldrich siRNA and siRNA Panels for GNS

Sigma-Aldrich shRNA for GNS

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GNS
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002076
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002076
untagged cDNA clones in CMV expression vector (see all 2): BC017742

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002076

UniProtKB/Swiss-Prot: GNS_HUMAN, P15586

Catalytic activity: Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate

units of heparan sulfate and keratan sulfate

Enzyme Number (IUBMB): EC 3.1.6.14

Genatlas biochemistry entry for GNS:

N-acetyl-glucosamine-6-sulfate sulfatase,lysosomal,acting an heparan sulfate,catalyzing the third

step of degradation of glycosaminoglycans (mucopolysaccharides)

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	17474147
GO:0008449	N-acetylglucosamine-6-sulfatase activity	TAS	3689315
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for GNS (Your Favorite Gene powered by Ingenuity)

Glycosaminoglycan Degradation

GeneDecks GNS for the pathways selected above

About GeneDecksing

5/18 Interacting proteins for GNS (P15586¹ ENSP00000258145³) via UniProtKB, MINT, and/or STRING (see all 18 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABL1	P00519¹	EBI-1752200, EBI-375543
FYN	P06241¹	EBI-1752200, EBI-515315
GRB2	P62993¹	EBI-1752200, EBI-401755
NCK1	P16333¹	EBI-1752200, EBI-389883
SRC	P12931¹	EBI-1752200, EBI-621482

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006027	glycosaminoglycan catabolic process	TAS	3689315
GO:0008152	metabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GNS
3 Novoseek chemical compound relationships for GNS gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
heparan sulfate	71.66	7	17998446 (1), 9600207 (1), 12573255 (1)
n-acetylglucosamine	69.90	7	7605804 (3), 8155645 (1), 9329460 (1), 8508132 (1) (see all 5)
steroid	11.08	2	11315200 (1), 2303452 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GNS)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002076

Sigma-Aldrich siRNA and siRNA Panels for GNS

Sigma-Aldrich shRNA for GNS

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002076

REFSEQ mRNAs for GNS gene:

NM_002076.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002076

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002076
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002076
                                 untagged cDNA clones in CMV expression vector (see all 2): BC017742

Additional cDNA sequence:

AK054660.1 AK223484.1 AK291771.1 AK296759.1 AK300350.1 AK302443.1 AK304158.1 AK308094.1

AK308454.1 BC012482.1 BC017742.1 BC038967.1 BX537363.1 CR596768.1 CR612218.1 CR612741.1

Z12173.1

14 DOTS entries:

DT.110919 DT.100826734 DT.91683440 DT.100044684 DT.101970251 DT.75156904 DT.100879064 DT.91894358

DT.100826731 DT.121159941 DT.80100041 DT.91981391 DT.95139719 DT.95139720

24/374 AceView cDNA sequences (see all 374 ):

BG117145 AA903771 BE880245 CD368163 CA395868 Z40162 BU619065 BM553384

CA427061 BC012482 AI924212 CA432650 AA973968 BU860244 CR612741 AU122141

BU166029 W56627 CK000462 BX537363 CD675868 BU857038 AA631011 BM722624

highest scoring ESTs for GNS:

Z12173 AA522891 AL548286 AL710718 AU077195 AU100259 AU133077 BC012482 BE819518 BG721679

Unigene Cluster for GNS:

Glucosamine (N-acetyl)-6-sulfatase

Hs.334534 [show with all ESTs]

Unigene Representative Sequence: NM_002076

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for GNS (see all 6 )

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12a	·	12b	^	13a	·	13b	^	14a	·	14b	^	15	^	16a	·	16b
SP1:			-		-		-																				-						-
SP2:
SP3:
SP4:
SP5:					-		-

About this scheme

ECgene alternative splicing isoforms for GNS

1 Ensembl transcript including schematic representation:

ENST00000258145

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GNS expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GNS

¹ / ² / ³

10 probe-sets matching GNS gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36263_g_at²^{, 3}	U95-A	1	1.00	1.00	0.93	0.80	Z12173	1.00	1.00	1.00	1
40432_at²^{, 3}	U95-A	1	1.00	1.00	0.84	1.48	AA522891	0.80	1.00	0.91	1
40433_at²^{, 3}	U95-A	1	1.00	1.00	0.87	0.80	W25921	0.20	1.00	0.72	1
36262_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.95	Z12173	1.00	1.00	1.00	1
212334_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE880245	0.40	1.00	0.76	1
212335_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW167793	0.40	1.00	0.76	1
203676_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002076	0.60	1.00	0.82	1
212334_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212335_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203676_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks GNS for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAAGTTTTAC

SOURCE GeneReport for Unigene cluster: Hs.334534
Expression variation in blood from EXPOLDB for GNS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GNS gene from 5/14 species (see all 14 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GNS¹	--	glucosamine (N-acetyl)-6-sulfatase	91.95(n) 97.06(a)	474429 XM_531660.1 XP_531660.1
chimpanzee (Pan troglodytes)	GNS¹	--	glucosamine (N-acetyl)-6-sulfatase	99.7(n) 100(a)	467054 XM_522454.2 XP_522454.1
cow (Bos taurus)	GNS¹	--	glucosamine (N-acetyl)-6-sulfatase	90.4(n) 94.75(a)	512444 NM_001075562.1 NP_001069030.1
rat (Rattus norvegicus)	Gns¹	--	glucosamine (N-acetyl)-6-sulfatase	86.34(n) 92.48(a)	299825 NM_001011989.1 NP_001011989.1
mouse (Mus musculus)	Gns^{1, 5}	10⁵	glucosamine (N-acetyl)-6-sulfatase^{1, 5}	84.62(n)¹ 91.51(a)¹	75612¹ NM_029364.2¹ NP_083640.1¹ AK011423⁵ AK030773⁵ (see all 57)

About this table Species with no ortholog for GNS

ENSEMBL Gene Tree for GNS

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GNS gene

SULF1² ARSK² SULF2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/226 NCBI SNPs in GNS are shown (see all 226 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 90)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2279597^1,2	A,C,F,H,O	63396519(+)	`AAAAAA/GAATAC`	1	--	ut3¹		13		EA NA EU WA	2158
	rs674^1,2	A,C,F,H,O	63396408(-)	`ACAGAT/CACACC`	1	--	ut3¹ ese³		13		MN EA NA EU WA	2182
	rs1244874^1,2	A,C,F,H,O	63393402(-)	`GTACTA/GGAAAT`	1	--	ng5¹		7		EU EA WA NA	556
	rs1061743^1,2	A,C,F,H	63394427(-)	`AGAAGG/CTTGCT`	1	--	ut3¹ ese³		12		MN EA NA EU WA	890
	rs11175525^1,2	A,C,F,H	63396377(+)	`TTTGAC/TTTTAG`	1	--	ut3¹ ese³		5		EA NA	320
	rs12309081^1,2	A,C,F,H	63395846(+)	`ACTTCT/CTTCCT`	1	--	ut3¹ trp³		7		EU EA WA NA	560
	rs17100604^1,2	C,F,H	63396222(+)	`TGTGAT/CGAACA`	1	--	ut3¹ ese³		7		NA EU EA WA	558
--	rs1269548^1,2	A,C	63395435(-)	`ggcacA/Gcacca`	1	--	ut3¹		0	--	--	--	--
	rs17100600^1,2	F,H	63394798(+)	`TTTATT/CTGGAA`	1	--	ut3¹		7		NA EU EA WA	562
	rs12822245^1,2	H	63440122(+)	`TTTATC/ACTAAT`	1	--	ng3¹ tfbs³		4		EU EA WA	414

About this table

HapMap Linkage Disequilibrium images for GNS (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 607664 disorders: 252940

UniProtKB/Swiss-Prot: GNS_HUMAN, P15586

Defects in GNS are the cause of mucopolysaccharidosis type 3D (MPS3D) [MIM:252940]; also

known as Sanfilippo D syndrome. MPS3D is a form of mucopolysaccharidosis type 3, an autosomal

recessive lysosomal storage disease due to impaired degradation of heparan sulfate. MPS3 is

characterized by severe central nervous system degeneration, but only mild somatic disease. Onset

of clinical features usually occurs between 2 and 6 years; severe neurologic degeneration occurs

in most patients between 6 and 10 years of age, and death occurs typically during the second or

third decade of life

3 Novoseek disease relationships for GNS gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mps iiid	97.59	13	12573255 (4), 17998446 (1), 10344792 (1), 9600207 (1)
sanfilippos syndrome	92.33	6	17998446 (2), 12573255 (1)
mucopolysaccharidosis	83.49	1	7605804 (1)

About this table

Human Gene Mutation Database: GNS

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/31 PubMed articles for GNS gene (see all 31 ):

Genomic basis of mucopolysaccharidosis type IIID (MIM 252940) revealed by sequencing of GNS encoding N-acetylglucosamine-6-sulfatase. (PubMed id 12573255)^{1, 3, 4} Mok A....Hegele R.A. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)^{3, 4} Zhang H.... Aebersold R. (2003)
A cDNA clone for human glucosamine-6-sulphatase reveals differences between arylsulphatases and non-arylsulphatases. (PubMed id 1463457)^{3, 4} Robertson D.A.... Hopwood J.J. (1992)
Human glucosamine-6-sulfatase cDNA reveals homology with steroid sulfatase. (PubMed id 3196333)^{3, 4} Robertson D.A.... Hopwood J.J. (1988)
Sanfilippo syndrome type D: natural history and identification of 3 novel mutations in the GNS Gene. (PubMed id 17998446)^{1, 3} Jansen A.C....Andermann E. (2007)
Morquio disease: isolation, characterization and expression of full- length cDNA for human N-acetylgalactosamine-6-sulfate sulfatase. (PubMed id 1755850)^{1, 3} Tomatsu S.... Orii T. (1991)
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)⁴ Chen R.... Zou H. (2009)
Identification and characterisation of an 8.7 kb deletion and a novel nonsense mutation in two Italian families with Sanfilippo syndrome type D (mucopolysaccharidosis IIID). (PubMed id 16990043)³ Beesley C.E....Strisciuglio P. (2007)
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)³ Wu C....Li S.S. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2799	HGNC: 4422	AceView: GNS	Ensembl:ENSG00000135677	euGenes: HUgn2799
ECgene: GNS	H-InvDB: GNS

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for GNS	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=GNS

Licensable Technologies for GNS
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GNS:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GNS-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GNS		Antibodies for GNS
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GNS		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GNS)
	Antibodies (GNS)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (GNS)
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Search Tocris compounds for GNS

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GNS

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GNS Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for GNS

Summaries
for GNS

Genomic Location
for GNS

Proteins
for GNS

Protein Domains/
Families
for GNS

Gene Function
for GNS

Pathways & Interactions
for GNS

Drugs & Compounds
for GNS

Transcripts
for GNS

Expression
for GNS

Orthologs
for GNS

Paralogs
for GNS

SNPs/Variants
for GNS

Disorders & Mutations
for GNS

Medical News
for GNS

Publications
for GNS

Search for GNS

Genome Databases showing GNS

Other Databases showing GNS

Specialized Databases showing GNS

Licensable Technologies
for GNS

Services
for GNS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GNS Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor GNS

Summariesfor GNS

Genomic Locationfor GNS

Proteinsfor GNS

Protein Domains/Familiesfor GNS

Gene Functionfor GNS

Pathways & Interactionsfor GNS

Drugs & Compoundsfor GNS

Transcriptsfor GNS

Expression for GNS

Orthologsfor GNS

Paralogsfor GNS

SNPs/Variantsfor GNS

Disorders & Mutationsfor GNS

Medical Newsfor GNS

Publicationsfor GNS

Search for GNS

Genome Databases showing GNS

Other Databases showing GNS

Specialized Databases showing GNS

Licensable Technologiesfor GNS

Servicesfor GNS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GNS

Summaries
for GNS

Genomic Location
for GNS

Proteins
for GNS

Protein Domains/
Families
for GNS

Gene Function
for GNS

Pathways & Interactions
for GNS

Drugs & Compounds
for GNS

Transcripts
for GNS

Expression
for GNS

Orthologs
for GNS

Paralogs
for GNS

SNPs/Variants
for GNS

Disorders & Mutations
for GNS

Medical News
for GNS

Publications
for GNS

Licensable Technologies
for GNS

Services
for GNS