Aliases for GNS Gene
External Ids for GNS Gene
Previous GeneCards Identifiers for GNS Gene
The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome. [provided by RefSeq, Jul 2008]
GeneCards Summary for GNS Gene
GNS (Glucosamine (N-Acetyl)-6-Sulfatase) is a Protein Coding gene. Diseases associated with GNS include mucopolysaccharidosis type iiid and muscular dystrophy-dystroglycanopathy , type a, 9. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include sulfuric ester hydrolase activity and N-acetylglucosamine-6-sulfatase activity. An important paralog of this gene is SULF1.