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Aliases for GNRHR2 Gene

Aliases for GNRHR2 Gene

  • Gonadotropin Releasing Hormone Receptor 2 (Pseudogene) 2 3 5
  • Type II GnRH Receptor 3 4
  • GnRH-II-R 3 4
  • Gonadotropin-Releasing Hormone (Type 2) Receptor 2, Pseudogene 3
  • Gonadotropin-Releasing Hormone (Type 2) Receptor 2 2
  • GnRH Receptor II 5TM 3
  • GnRH II Receptor 4

External Ids for GNRHR2 Gene

Previous GeneCards Identifiers for GNRHR2 Gene

  • GC01M144030
  • GC01M142096
  • GC01M143236
  • GC01M143258
  • GC01M142998
  • GC01M144221
  • GC01M145509
  • GC01M119475

Summaries for GNRHR2 Gene

Entrez Gene Summary for GNRHR2 Gene

  • In non-hominoid primates and non-mammalian vertebrates, the gonadotropin releasing hormone 2 receptor gene (GnRHR2) encodes a seven-transmembrane G-protein coupled receptor. However, in human, the corresponding reading frame contains a premature stop codon, which has been suggested to encode a selenocysteine residue, but there is no solid evidence for selenocysteine incorporation (PMID: 12538601). It appears that the human GnRHR2 transcription occurs but the gene does not likely produce a functional multi-transmembrane protein. A non-transcribed pseudogene of GnRHR2 is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for GNRHR2 Gene

GNRHR2 (Gonadotropin Releasing Hormone Receptor 2 (Pseudogene)) is a Pseudogene. Among its related pathways are Signaling by GPCR and Hormone ligand-binding receptors. GO annotations related to this gene include peptide binding and gonadotropin-releasing hormone receptor activity.

UniProtKB/Swiss-Prot for GNRHR2 Gene

  • Putative receptor for gonadotropin releasing hormone II (GnRH II) which is most probably non-functional.

Tocris Summary for GNRHR2 Gene

  • Gonadotropin-releasing hormone (GnRH) receptors are a group of Gq/11-protein-coupled receptors that are divided into two subtypes; GnRH and GnRH2. GnRH receptors are predominantly expressed by pituitary gonadotrophs. GnRH2 is silenced in humans.

Gene Wiki entry for GNRHR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNRHR2 Gene

Genomics for GNRHR2 Gene

Regulatory Elements for GNRHR2 Gene

Enhancers for GNRHR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F145976 1.6 FANTOM5 ENCODE 11 +63.0 62973 10.0 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A YBX1 FEZF1 ZNF2 YY1 POLR3C ANKRD35 NOTCH2NL HFE2 RBM8A LIX1L-AS1 PEX11B GNRHR2 LIX1L TXNIP
GH01F145990 1.6 FANTOM5 ENCODE 10.9 +76.3 76330 10.5 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 LIX1L-AS1 NOTCH2NL POLR3C TXNIP HFE2 RBM8A PEX11B GNRHR2 CD160 ANKRD34A
GH01F146034 1.5 Ensembl ENCODE 11.4 +118.6 118565 5.6 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 TBX21 ZFP41 POLR3C NOTCH2NL ANKRD35 NUDT17 TXNIP GNRHR2 LINC01719 NBPF12 HFE2 TRH-GTG1-1
GH01F146006 1.2 Ensembl ENCODE 11.3 +87.8 87788 2.8 HDGF TBP HDAC1 CBX3 ARNT TBL1XR1 ZNF2 RAD21 RFX5 CHAMP1 POLR3C NOTCH2NL PEX11B GNRHR2 ITGA10 ANKRD35 LINC01719 TXNIP TRE-CTC1-1
GH01F145959 1.1 ENCODE 12.3 +43.4 43420 6.1 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 POLR3C LIX1L-AS1 RBM8A TXNIP PEX11B GNRHR2 NOTCH2NL LIX1L ANKRD34A ENSG00000278431
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GNRHR2 on UCSC Golden Path with GeneCards custom track

Promoters for GNRHR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001524426 -13 2401 HDGF ATF1 ARNT ZFP64 ARID4B SIN3A GLI4 BRCA1 YY1 GLIS2

Genomic Location for GNRHR2 Gene

Chromosome:
1
Start:
145,919,013 bp from pter
End:
145,925,341 bp from pter
Size:
6,329 bases
Orientation:
Plus strand

Genomic View for GNRHR2 Gene

Genes around GNRHR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNRHR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNRHR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNRHR2 Gene

Proteins for GNRHR2 Gene

  • Protein details for GNRHR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P88-GNRR2_HUMAN
    Recommended name:
    Putative gonadotropin-releasing hormone II receptor
    Protein Accession:
    Q96P88
    Secondary Accessions:
    • E7EN27
    • Q8TCX8

    Protein attributes for GNRHR2 Gene

    Size:
    292 amino acids
    Molecular mass:
    32537 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL27000.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for GNRHR2 Gene

Post-translational modifications for GNRHR2 Gene

No data available for DME Specific Peptides for GNRHR2 Gene

Domains & Families for GNRHR2 Gene

Gene Families for GNRHR2 Gene

Suggested Antigen Peptide Sequences for GNRHR2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96P88

UniProtKB/Swiss-Prot:

GNRR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GNRHR2: view

Function for GNRHR2 Gene

Molecular function for GNRHR2 Gene

UniProtKB/Swiss-Prot Function:
Putative receptor for gonadotropin releasing hormone II (GnRH II) which is most probably non-functional.

Gene Ontology (GO) - Molecular Function for GNRHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004968 gonadotropin-releasing hormone receptor activity IBA --
GO:0042277 peptide binding IBA --
genes like me logo Genes that share ontologies with GNRHR2: view
genes like me logo Genes that share phenotypes with GNRHR2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GNRHR2 Gene

Localization for GNRHR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNRHR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNRHR2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GNRHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with GNRHR2: view

Pathways & Interactions for GNRHR2 Gene

genes like me logo Genes that share pathways with GNRHR2: view

Interacting Proteins for GNRHR2 Gene

Selected Interacting proteins: Q96P88-GNRR2_HUMAN for GNRHR2 Gene via IID

Symbol External ID(s) Details
GNRH2

Gene Ontology (GO) - Biological Process for GNRHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0097211 cellular response to gonadotropin-releasing hormone IBA --
genes like me logo Genes that share ontologies with GNRHR2: view

No data available for SIGNOR curated interactions for GNRHR2 Gene

Drugs & Compounds for GNRHR2 Gene

(17) Drugs for GNRHR2 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Danazol Approved Pharma antagonist, Target, negative modulator 16
Gonadorelin Approved, Vet_approved Pharma agonist, Target 0
Nafarelin Approved Pharma Full agonist, Agonist, agonist, Target 4
Degarelix Approved December of 2008 Pharma Antagonist 0
histrelin Approved Pharma Full agonist, Agonist 0

(4) Additional Compounds for GNRHR2 Gene - From: IUPHAR, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]GnRH II (human)
Full agonist, Agonist
trptorelix-1
Antagonist
Cetrorelix Acetate
145672-81-7

(5) Tocris Compounds for GNRHR2 Gene

Compound Action Cas Number
AG 045572 Selective GnRH receptor antagonist 263847-55-8
Cetrorelix Acetate Potent GnRH receptor antagonist 145672-81-7
Goserelin acetate GnRH receptor agonist 1233494-97-7
Leuprolide GnRH receptor agonist 53714-56-0
WAY 207024 dihydrochloride GnRH receptor antagonist 872002-73-8

(4) ApexBio Compounds for GNRHR2 Gene

Compound Action Cas Number
AG 045572 Selective GnRH receptor antagonist 263847-55-8
GnRH Associated Peptide (GAP) (1-13), human Asp-Ala-Glu-Asn-Leu-Ile-Asp-Ser-Phe-Gln-Glu-Ile-Val 100111-07-7
T 98475 199119-18-1
WAY 207024 dihydrochloride GnRH-R antagonist, potent 872002-73-8
genes like me logo Genes that share compounds with GNRHR2: view

Transcripts for GNRHR2 Gene

mRNA/cDNA for GNRHR2 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNRHR2 Gene

Gonadotropin-releasing hormone (type 2) receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNRHR2 Gene

No ASD Table

Relevant External Links for GNRHR2 Gene

GeneLoc Exon Structure for
GNRHR2
ECgene alternative splicing isoforms for
GNRHR2

Expression for GNRHR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GNRHR2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GNRHR2 Gene



NURSA nuclear receptor signaling pathways regulating expression of GNRHR2 Gene:

GNRHR2

SOURCE GeneReport for Unigene cluster for GNRHR2 Gene:

Hs.356873

mRNA Expression by UniProt/SwissProt for GNRHR2 Gene:

Q96P88-GNRR2_HUMAN
Tissue specificity: Expressed in many tissues.
genes like me logo Genes that share expression patterns with GNRHR2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for GNRHR2 Gene

Orthologs for GNRHR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GNRHR2 Gene

Organism Taxonomy Gene Similarity Type Details
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11761 34
African clawed frog
(Xenopus laevis)
Amphibia gnrhr2-A 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8048 34
fruit fly
(Drosophila melanogaster)
Insecta GRHR 36
  • 30 (a)
Species where no ortholog for GNRHR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GNRHR2 Gene

ENSEMBL:
Gene Tree for GNRHR2 (if available)
TreeFam:
Gene Tree for GNRHR2 (if available)

Paralogs for GNRHR2 Gene

(6) SIMAP similar genes for GNRHR2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GNRHR2: view

No data available for Paralogs for GNRHR2 Gene

Variants for GNRHR2 Gene

Sequence variations from dbSNP and Humsavar for GNRHR2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs397515419 Pathogenic 145,917,809(-) CCGCC(C/T)AGTAT intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, stop-gained
rs1048870 -- 145,925,781(-) TTAAT(C/T)TCTTA downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1058534 -- 145,924,717(-) AGCTC(A/G)CCTCC intron-variant, utr-variant-3-prime
rs10910821 -- 145,918,026(-) ATTCA(A/G)TAGTG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs112545186 -- 145,920,879(+) TTATT(-/ATT)ATACT intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GNRHR2 Gene

Variant ID Type Subtype PubMed ID
esv3587419 CNV gain 21293372
nsv1005055 CNV loss 25217958
nsv2710 CNV insertion 18451855
nsv831381 CNV gain 17160897
nsv946264 CNV duplication 23825009

Relevant External Links for GNRHR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNRHR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GNRHR2 Gene

Disorders for GNRHR2 Gene

Relevant External Links for GNRHR2

Genetic Association Database (GAD)
GNRHR2
Human Genome Epidemiology (HuGE) Navigator
GNRHR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNRHR2

No disorders were found for GNRHR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNRHR2 Gene

Publications for GNRHR2 Gene

  1. The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci. (PMID: 11707068) Faurholm B. … Katz A.A. (Genomics 2001) 2 3 4 22 64
  2. Retention and silencing of prepro-GnRH-II and type II GnRH receptor genes in mammals. (PMID: 19657181) Stewart A.J. … Morgan K. (Neuroendocrinology 2009) 3 4 22 64
  3. A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12. (PMID: 12538601) Morgan K. … Millar R.P. (Endocrinology 2003) 3 4 22 64
  4. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PMID: 20398908) Saus E. … Estivill X. (J Psychiatr Res 2010) 3 46 64
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 46 64

Products for GNRHR2 Gene

Sources for GNRHR2 Gene

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