Aliases for GNRHR2 Gene
- Gonadotropin Releasing Hormone Receptor 2 (Pseudogene) 2 3
- Gonadotropin Releasing Hormone Receptor 2, Pseudogene 3 5
- Type II GnRH Receptor 3 4
- GnRH-II-R 3 4
- Gonadotropin-Releasing Hormone (Type 2) Receptor 2, Pseudogene 3
- Gonadotropin-Releasing Hormone (Type 2) Receptor 2 2
- GnRH Receptor II 5TM 3
- GnRH II Receptor 4
External Ids for GNRHR2 Gene
Previous GeneCards Identifiers for GNRHR2 Gene
In non-hominoid primates and non-mammalian vertebrates, the gonadotropin releasing hormone 2 receptor gene (GnRHR2) encodes a seven-transmembrane G-protein coupled receptor. However, in human, the corresponding reading frame contains a premature stop codon, which has been suggested to encode a selenocysteine residue, but there is no solid evidence for selenocysteine incorporation (PMID: 12538601). It appears that the human GnRHR2 transcription occurs but the gene does not likely produce a functional multi-transmembrane protein. A non-transcribed pseudogene of GnRHR2 is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2013]
GeneCards Summary for GNRHR2 Gene
GNRHR2 (Gonadotropin Releasing Hormone Receptor 2 (Pseudogene)) is a Pseudogene. Among its related pathways are Peptide ligand-binding receptors and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include peptide binding and gonadotropin-releasing hormone receptor activity.
UniProtKB/Swiss-Prot for GNRHR2 Gene
Putative receptor for gonadotropin releasing hormone II (GnRH II) which is most probably non-functional.
Gonadotropin-releasing hormone (GnRH) receptors are a group of Gq/11-protein-coupled receptors that are divided into two subtypes; GnRH and GnRH2. GnRH receptors are predominantly expressed by pituitary gonadotrophs. GnRH2 is silenced in humans.