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Aliases for GNRHR2 Gene

Aliases for GNRHR2 Gene

  • Gonadotropin Releasing Hormone Receptor 2 (Pseudogene) 2 3
  • Gonadotropin Releasing Hormone Receptor 2, Pseudogene 3 5
  • Type II GnRH Receptor 3 4
  • GnRH-II-R 3 4
  • Gonadotropin-Releasing Hormone (Type 2) Receptor 2, Pseudogene 3
  • Gonadotropin-Releasing Hormone (Type 2) Receptor 2 2
  • GnRH Receptor II 5TM 3
  • GnRH II Receptor 4

External Ids for GNRHR2 Gene

Previous GeneCards Identifiers for GNRHR2 Gene

  • GC01M144030
  • GC01M142096
  • GC01M143236
  • GC01M143258
  • GC01M142998
  • GC01M144221
  • GC01M145509
  • GC01M119475

Summaries for GNRHR2 Gene

Entrez Gene Summary for GNRHR2 Gene

  • In non-hominoid primates and non-mammalian vertebrates, the gonadotropin releasing hormone 2 receptor gene (GnRHR2) encodes a seven-transmembrane G-protein coupled receptor. However, in human, the corresponding reading frame contains a premature stop codon, which has been suggested to encode a selenocysteine residue, but there is no solid evidence for selenocysteine incorporation (PMID: 12538601). It appears that the human GnRHR2 transcription occurs but the gene does not likely produce a functional multi-transmembrane protein. A non-transcribed pseudogene of GnRHR2 is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for GNRHR2 Gene

GNRHR2 (Gonadotropin Releasing Hormone Receptor 2 (Pseudogene)) is a Pseudogene. Among its related pathways are Peptide ligand-binding receptors and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include peptide binding and gonadotropin-releasing hormone receptor activity.

UniProtKB/Swiss-Prot for GNRHR2 Gene

  • Putative receptor for gonadotropin releasing hormone II (GnRH II) which is most probably non-functional.

Tocris Summary for GNRHR2 Gene

  • Gonadotropin-releasing hormone (GnRH) receptors are a group of Gq/11-protein-coupled receptors that are divided into two subtypes; GnRH and GnRH2. GnRH receptors are predominantly expressed by pituitary gonadotrophs. GnRH2 is silenced in humans.

Gene Wiki entry for GNRHR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNRHR2 Gene

Genomics for GNRHR2 Gene

Regulatory Elements for GNRHR2 Gene

Enhancers for GNRHR2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GNRHR2 on UCSC Golden Path with GeneCards custom track

Promoters for GNRHR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GNRHR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GNRHR2 Gene

145,919,013 bp from pter
145,925,341 bp from pter
6,329 bases
Plus strand

Genomic View for GNRHR2 Gene

Genes around GNRHR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNRHR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNRHR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNRHR2 Gene

Proteins for GNRHR2 Gene

  • Protein details for GNRHR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative gonadotropin-releasing hormone II receptor
    Protein Accession:
    Secondary Accessions:
    • E7EN27
    • Q8TCX8

    Protein attributes for GNRHR2 Gene

    292 amino acids
    Molecular mass:
    32537 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAL27000.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for GNRHR2 Gene

Proteomics data for GNRHR2 Gene at MOPED

Post-translational modifications for GNRHR2 Gene

No data available for DME Specific Peptides for GNRHR2 Gene

Domains & Families for GNRHR2 Gene

Gene Families for GNRHR2 Gene

Suggested Antigen Peptide Sequences for GNRHR2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GNRHR2: view

Function for GNRHR2 Gene

Molecular function for GNRHR2 Gene

UniProtKB/Swiss-Prot Function:
Putative receptor for gonadotropin releasing hormone II (GnRH II) which is most probably non-functional.
genes like me logo Genes that share phenotypes with GNRHR2: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GNRHR2 Gene

Localization for GNRHR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNRHR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GNRHR2 Gene COMPARTMENTS Subcellular localization image for GNRHR2 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for GNRHR2 Gene

Pathways & Interactions for GNRHR2 Gene

genes like me logo Genes that share pathways with GNRHR2: view

Interacting Proteins for GNRHR2 Gene

Gene Ontology (GO) - Biological Process for GNRHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GNRHR2: view

No data available for SIGNOR curated interactions for GNRHR2 Gene

Drugs & Compounds for GNRHR2 Gene

(13) Drugs for GNRHR2 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nafarelin Approved Pharma Full agonist, Agonist, agonist, Target GnRH receptor agonist 3
Danazol Approved Pharma antagonist, Target, negative modulator 15
Gonadorelin Approved Pharma agonist, Target 0
Degarelix Approved December of 2008 Pharma Antagonist 0
Leuprolide Approved, Investigational Pharma Full agonist, Agonist GnRH receptor agonist 282

(6) Additional Compounds for GNRHR2 Gene - From: IUPHAR, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]GnRH II (human)
Full agonist, Agonist
AG 045572
Goserelin acetate
T 98475

(5) Tocris Compounds for GNRHR2 Gene

Compound Action Cas Number
AG 045572 Selective GnRH receptor antagonist 263847-55-8
Goserelin acetate GnRH receptor agonist 1233494-97-7
Leuprolide GnRH receptor agonist 53714-56-0
Nafarelin GnRH receptor agonist 76932-56-4
T 98475 GnRH receptor antagonist 199119-18-1

(1) ApexBio Compounds for GNRHR2 Gene

Compound Action Cas Number
GnRH Associated Peptide (GAP) (1-13), human Asp-Ala-Glu-Asn-Leu-Ile-Asp-Ser-Phe-Gln-Glu-Ile-Val 100111-07-7
genes like me logo Genes that share compounds with GNRHR2: view

Transcripts for GNRHR2 Gene

mRNA/cDNA for GNRHR2 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNRHR2 Gene

Gonadotropin-releasing hormone (type 2) receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNRHR2 Gene

No ASD Table

Relevant External Links for GNRHR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GNRHR2 Gene

mRNA expression in normal human tissues for GNRHR2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GNRHR2 Gene

SOURCE GeneReport for Unigene cluster for GNRHR2 Gene Hs.356873

mRNA Expression by UniProt/SwissProt for GNRHR2 Gene

Tissue specificity: Expressed in many tissues.
genes like me logo Genes that share expression patterns with GNRHR2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for GNRHR2 Gene

Orthologs for GNRHR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GNRHR2 Gene

Organism Taxonomy Gene Similarity Type Details
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11761 35
African clawed frog
(Xenopus laevis)
Amphibia gnrhr2-A 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8048 35
fruit fly
(Drosophila melanogaster)
Insecta GRHR 37
  • 30 (a)
Species with no ortholog for GNRHR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GNRHR2 Gene

Gene Tree for GNRHR2 (if available)
Gene Tree for GNRHR2 (if available)

Paralogs for GNRHR2 Gene

(6) SIMAP similar genes for GNRHR2 Gene using alignment to 2 proteins: Pseudogenes for GNRHR2 Gene

genes like me logo Genes that share paralogs with GNRHR2: view

No data available for Paralogs for GNRHR2 Gene

Variants for GNRHR2 Gene

Sequence variations from dbSNP and Humsavar for GNRHR2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1475470 -- 145,920,994(+) CCAAT(C/T)TCACC intron-variant, downstream-variant-500B
rs75708569 -- 145,921,010(+) GCCCC(A/T)ATCTG intron-variant, downstream-variant-500B
rs114833371 -- 145,921,039(-) ATAGA(C/T)CCCCA intron-variant, downstream-variant-500B
rs587771917 -- 145,921,045(+) CTCTT(A/C)ATAGA intron-variant, downstream-variant-500B
rs750591295 -- 145,920,965(-) AAACC(A/G)CGTGT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for GNRHR2 Gene

Variant ID Type Subtype PubMed ID
nsv7181 OTHER Inversion 18451855
dgv15n16 CNV Deletion 17901297
dgv46e201 CNV Deletion 23290073
dgv105e1 CNV Complex 17122850
esv2422428 CNV Duplication 17116639
dgv347n71 CNV Gain 21882294
nsv831370 CNV Gain 17160897
nsv831381 CNV Gain 17160897
nsv2710 CNV Insertion 18451855

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for GNRHR2 Gene

Disorders for GNRHR2 Gene

Relevant External Links for GNRHR2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GNRHR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNRHR2 Gene

Publications for GNRHR2 Gene

  1. The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci. (PMID: 11707068) Faurholm B. … Katz A.A. (Genomics 2001) 2 3 4 23 67
  2. Conserved amino acid residues that are important for ligand binding in the type I gonadotropin-releasing hormone (GnRH) receptor are required for high potency of GnRH II at the type II GnRH receptor. (PMID: 16973761) Mamputha S. … Flanagan C.A. (Mol. Endocrinol. 2007) 23 25 26
  3. Gonadotropin-releasing hormone (GnRH) receptors in tumors: a new rationale for the therapeutical application of GnRH analogs in cancer patients? (PMID: 16712461) Montagnani Marelli M. … Limonta P. (Curr Cancer Drug Targets 2006) 23 25 26
  4. Bovine and ovine gonadotropin-releasing hormone (GnRH)-II ligand precursors and type II GnRH receptor genes are functionally inactivated. (PMID: 16916952) Morgan K. … Millar R.P. (Endocrinology 2006) 23 25 26
  5. Retention and silencing of prepro-GnRH-II and type II GnRH receptor genes in mammals. (PMID: 19657181) Stewart A.J. … Morgan K. (Neuroendocrinology 2009) 3 23

Products for GNRHR2 Gene

Sources for GNRHR2 Gene