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Aliases for GNRHR Gene

Aliases for GNRHR Gene

  • Gonadotropin-Releasing Hormone Receptor 2 3
  • GnRH Receptor 3 4
  • GnRH-R 3 4
  • GRHR 3 4
  • Gonadotropin-Releasing Hormone (Type 1) Receptor 1 3
  • Leutinizing Hormone Releasing Horomone Receptor 3
  • Leutinizing-Releasing Hormone Receptor 3
  • Type I GnRH Receptor 3
  • Luliberin Receptor 3
  • GNRHR1 3
  • LHRHR 3
  • LRHR 3
  • HH7 3

External Ids for GNRHR Gene

Previous HGNC Symbols for GNRHR Gene

  • GRHR

Previous GeneCards Identifiers for GNRHR Gene

  • GC04M068517
  • GC04M068542
  • GC04M068609
  • GC04M068608
  • GC04M068434
  • GC04M068285
  • GC04M064516

Summaries for GNRHR Gene

Entrez Gene Summary for GNRHR Gene

  • This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GNRHR Gene

GNRHR (Gonadotropin-Releasing Hormone Receptor) is a Protein Coding gene. Diseases associated with GNRHR include gnrhr-related isolated gonadotropin-releasing hormone deficiency and hypogonadotropic hypogonadism 7 without anosmia. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include G-protein coupled receptor activity and gonadotropin-releasing hormone receptor activity. An important paralog of this gene is AVPR1B.

UniProtKB/Swiss-Prot for GNRHR Gene

  • Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling

Tocris Summary for GNRHR Gene

  • Gonadotropin-releasing hormone (GnRH) receptors are a group of Gq/11-protein-coupled receptors that are divided into two subtypes; GnRH and GnRH2. GnRH receptors are predominantly expressed by pituitary gonadotrophs. GnRH2 is silenced in humans.

Gene Wiki entry for GNRHR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNRHR Gene

Genomics for GNRHR Gene

Regulatory Elements for GNRHR Gene

Genomic Location for GNRHR Gene

Chromosome:
4
Start:
67,737,375 bp from pter
End:
67,756,086 bp from pter
Size:
18,712 bases
Orientation:
Minus strand

Genomic View for GNRHR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for GNRHR Gene

Proteins for GNRHR Gene

  • Protein details for GNRHR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30968-GNRHR_HUMAN
    Recommended name:
    Gonadotropin-releasing hormone receptor
    Protein Accession:
    P30968
    Secondary Accessions:
    • O75793
    • Q14D13
    • Q92644

    Protein attributes for GNRHR Gene

    Size:
    328 amino acids
    Molecular mass:
    37731 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GNRHR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GNRHR Gene

Proteomics data for GNRHR Gene at MOPED

Post-translational modifications for GNRHR Gene

  • Glycosylation at Asn 18 and Asn 102

Other Protein References for GNRHR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNRHR Gene

Domains & Families for GNRHR Gene

Gene Families for GNRHR Gene

Suggested Antigen Peptide Sequences for GNRHR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30968

UniProtKB/Swiss-Prot:

GNRHR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GNRHR: view

Function for GNRHR Gene

Molecular function for GNRHR Gene

GENATLAS Biochemistry:
gonadotropin releasing hormone receptor,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling

Gene Ontology (GO) - Molecular Function for GNRHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004968 gonadotropin-releasing hormone receptor activity IEA --
GO:0042277 peptide binding IBA --
genes like me logo Genes that share ontologies with GNRHR: view
genes like me logo Genes that share phenotypes with GNRHR: view

Animal Model Products

miRNA for GNRHR Gene

miRTarBase miRNAs that target GNRHR

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GNRHR Gene

Localization for GNRHR Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNRHR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNRHR Gene COMPARTMENTS Subcellular localization image for GNRHR gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for GNRHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8386108
GO:0016020 membrane TAS 9259321
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with GNRHR: view

Pathways & Interactions for GNRHR Gene

genes like me logo Genes that share pathways with GNRHR: view

Pathways by source for GNRHR Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GNRHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007275 multicellular organismal development TAS 10686191
GO:0097211 cellular response to gonadotropin-releasing hormone TAS 8386108
genes like me logo Genes that share ontologies with GNRHR: view

No data available for SIGNOR curated interactions for GNRHR Gene

Drugs & Compounds for GNRHR Gene

(75) Drugs for GNRHR Gene - From: NovoSeek, IUPHAR, DGIdb, DrugBank, ApexBio, Tocris, HMDB, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Degarelix Approved December of 2008 Pharma Antagonist, Target, antagonist 0
Nafarelin Approved Pharma Full agonist, Agonist, agonist, Target GnRH receptor agonist 3
Cetrorelix Approved, Investigational Pharma Antagonist, antagonist, Target 53
Goserelin Approved Pharma Full agonist, Agonist, activator, Target, agonist 210
Leuprolide Approved, Investigational Pharma Full agonist, Agonist, activator, Target, agonist GnRH receptor agonist 265

(32) Additional Compounds for GNRHR Gene - From: NovoSeek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
antide
Antagonist
HMA
Negative, Allosteric regulator
TAK-013
Antagonist
AG 045572
263847-55-8
Goserelin acetate
1233494-97-7
genes like me logo Genes that share compounds with GNRHR: view

Transcripts for GNRHR Gene

mRNA/cDNA for GNRHR Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNRHR Gene

Gonadotropin-releasing hormone receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNRHR Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for GNRHR Gene

GeneLoc Exon Structure for
GNRHR
ECgene alternative splicing isoforms for
GNRHR

Expression for GNRHR Gene

mRNA expression in normal human tissues for GNRHR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNRHR Gene

This gene is overexpressed in Pituitary (x18.2).

SOURCE GeneReport for Unigene cluster for GNRHR Gene Hs.407587

mRNA Expression by UniProt/SwissProt for GNRHR Gene

P30968-GNRHR_HUMAN
Tissue specificity: Pituitary, ovary, testis, breast and prostate but not in liver and spleen
genes like me logo Genes that share expression patterns with GNRHR: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GNRHR Gene

Orthologs for GNRHR Gene

This gene was present in the common ancestor of animals.

Orthologs for GNRHR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GNRHR 35
  • 89.13 (n)
  • 90.55 (a)
GNRHR 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNRHR 35
  • 90.97 (n)
  • 92.92 (a)
GNRHR 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gnrhr 35
  • 85.42 (n)
  • 89.6 (a)
Gnrhr 16
Gnrhr 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GNRHR 35
  • 99.19 (n)
  • 99.09 (a)
GNRHR 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gnrhr 35
  • 85.63 (n)
  • 88.07 (a)
oppossum
(Monodelphis domestica)
Mammalia GNRHR 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
GNRHR 36
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves GNRHR1/III 36
  • 32 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia GNRHR 36
  • 36 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia gnrhr1-A 35
zebrafish
(Danio rerio)
Actinopterygii GNRHR 36
  • 32 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta GRHR 37
  • 32 (a)
GRHRII 37
  • 29 (a)
GRHR 36
  • 21 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F54D7.3 37
  • 27 (a)
gnrr-1 36
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToOne
Species with no ortholog for GNRHR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GNRHR Gene

ENSEMBL:
Gene Tree for GNRHR (if available)
TreeFam:
Gene Tree for GNRHR (if available)

Paralogs for GNRHR Gene

Paralogs for GNRHR Gene

(3) SIMAP similar genes for GNRHR Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GNRHR: view

Variants for GNRHR Gene

Sequence variations from dbSNP and Humsavar for GNRHR Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_019311 Hypogonadotropic hypogonadism 7 with or without anosmia (HH7)
VAR_019312 Hypogonadotropic hypogonadism 7 with or without anosmia (HH7)
VAR_019313 Hypogonadotropic hypogonadism 7 with or without anosmia (HH7)
VAR_019314 Hypogonadotropic hypogonadism 7 with or without anosmia (HH7)
VAR_019315 Hypogonadotropic hypogonadism 7 with or without anosmia (HH7)

Structural Variations from Database of Genomic Variants (DGV) for GNRHR Gene

Variant ID Type Subtype PubMed ID
nsv879214 CNV Gain 21882294

Variation tolerance for GNRHR Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNRHR Gene

HapMap Linkage Disequilibrium report
GNRHR
Human Gene Mutation Database (HGMD)
GNRHR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNRHR Gene

Disorders for GNRHR Gene

MalaCards: The human disease database

(16) MalaCards diseases for GNRHR Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

- elite association
Search GNRHR in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

GNRHR_HUMAN
  • Hypogonadotropic hypogonadism 7 with or without anosmia (HH7) [MIM:146110]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269 PubMed:10022417, ECO:0000269 PubMed:10084584, ECO:0000269 PubMed:10523035, ECO:0000269 PubMed:11318785, ECO:0000269 PubMed:11397842, ECO:0000269 PubMed:11397871, ECO:0000269 PubMed:12679486, ECO:0000269 PubMed:23643382, ECO:0000269 PubMed:25077900, ECO:0000269 PubMed:9371856, ECO:0000269 PubMed:9425890}. Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in GNRHR as well as in other HH-associated genes including FGFR1 (PubMed:23643382). {ECO:0000269 PubMed:23643382}.

Genatlas disease for GNRHR Gene

idiopathic hypogonadotropic hypogonadism

Relevant External Links for GNRHR

Genetic Association Database (GAD)
GNRHR
Human Genome Epidemiology (HuGE) Navigator
GNRHR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNRHR
genes like me logo Genes that share disorders with GNRHR: view

Publications for GNRHR Gene

  1. Degarelix: a gonadotropin-releasing hormone antagonist for the management of prostate cancer. (PMID: 20110043) Steinberg M. (Clin Ther 2009) 23 25 26 67
  2. Abarelix and other gonadotrophin-releasing hormone antagonists in prostate cancer. (PMID: 20053189) Kirby R.S. … Clarke N. (BJU Int. 2009) 23 25 26 67
  3. Effect of leuprolide and cetrorelix on cell growth, apoptosis, and GnRH receptor expression in primary cell cultures from human prostate carcinoma. (PMID: 16809153) CastellA^n E. … Huidobro C. (Cancer Invest. 2006) 23 25 26 67
  4. Synthesis and biological activity of GnRH antagonists modified at position 3 with 3-(2-methoxy-5-pyridyl)-alanine. (PMID: 15705170) Samant M.P. … Rivier J.E. (J. Pept. Res. 2005) 23 25 26 67
  5. Conserved amino acid residues that are important for ligand binding in the type I gonadotropin-releasing hormone (GnRH) receptor are required for high potency of GnRH II at the type II GnRH receptor. (PMID: 16973761) Mamputha S. … Flanagan C.A. (Mol. Endocrinol. 2007) 25 26 67

Products for GNRHR Gene

Sources for GNRHR Gene

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