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Aliases for GNRH2 Gene

Aliases for GNRH2 Gene

  • Gonadotropin-Releasing Hormone 2 2 3
  • Progonadoliberin II 3 4
  • Luteinizing Hormone-Releasing Hormone II 3
  • Progonadoliberin-2 3
  • Luliberin II 3
  • GnRH-II 3
  • LH-RHII 3

External Ids for GNRH2 Gene

Previous GeneCards Identifiers for GNRH2 Gene

  • GC20P003012
  • GC20P002972
  • GC20P003019
  • GC20P003033
  • GC20P003038
  • GC20P003043

Summaries for GNRH2 Gene

Entrez Gene Summary for GNRH2 Gene

  • The protein encoded by this gene is a preproprotein that is cleaved to form a secreted 10 aa peptide hormone. The secreted decapeptide regulates reproduction in females by stimulating the secretion of both luteinizing- and follicle-stimulating hormones. Three transcript variants that encode unique proproteins but the same peptide hormone have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GNRH2 Gene

GNRH2 (Gonadotropin-Releasing Hormone 2) is a Protein Coding gene. Diseases associated with GNRH2 include medulloblastoma. Among its related pathways are Signaling by GPCR and NF-KappaB Family Pathway. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot for GNRH2 Gene

  • Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones

Gene Wiki entry for GNRH2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNRH2 Gene

Genomics for GNRH2 Gene

Regulatory Elements for GNRH2 Gene

Genomic Location for GNRH2 Gene

Start:
3,042,814 bp from pter
End:
3,045,870 bp from pter
Size:
3,057 bases
Orientation:
Plus strand

Genomic View for GNRH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNRH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNRH2 Gene

Proteins for GNRH2 Gene

  • Protein details for GNRH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43555-GON2_HUMAN
    Recommended name:
    Progonadoliberin-2
    Protein Accession:
    O43555
    Secondary Accessions:
    • Q14C68
    • Q14C69
    • Q9BYN9
    • Q9BYP0

    Protein attributes for GNRH2 Gene

    Size:
    120 amino acids
    Molecular mass:
    12918 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GNRH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GNRH2 Gene

Proteomics data for GNRH2 Gene at MOPED

Post-translational modifications for GNRH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNRH2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GNRH2 Gene

Domains for GNRH2 Gene

Gene Families for GNRH2 Gene

HGNC:

Protein Domains for GNRH2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GNRH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43555

UniProtKB/Swiss-Prot:

GON2_HUMAN :
  • O43555
Family:
  • Belongs to the GnRH family.
genes like me logo Genes that share domains with GNRH2: view

Function for GNRH2 Gene

Molecular function for GNRH2 Gene

GENATLAS Biochemistry: gonadotropin releasing hormone 2,mesencephalic form,expressed in midbrain,kidney,bone marrow prostate,including a GNRH-associated peptide
UniProtKB/Swiss-Prot Function: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones

Gene Ontology (GO) - Molecular Function for GNRH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with GNRH2: view
genes like me logo Genes that share phenotypes with GNRH2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GNRH2 Gene

Localization for GNRH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNRH2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNRH2 Gene COMPARTMENTS Subcellular localization image for GNRH2 gene
Compartment Confidence
extracellular 5
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GNRH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with GNRH2: view

Pathways for GNRH2 Gene

genes like me logo Genes that share pathways with GNRH2: view

Interacting Proteins for GNRH2 Gene

Gene Ontology (GO) - Biological Process for GNRH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9419371
GO:0007275 multicellular organismal development IEA --
genes like me logo Genes that share ontologies with GNRH2: view

Compounds for GNRH2 Gene

(6) Novoseek inferred chemical compound relationships for GNRH2 Gene

Compound -log(P) Hits PubMed IDs
gnrh 86.5 49
cetrorelix 74.1 2
ribonucleic acid 44.5 1
mifepristone 41.2 3
progesterone 31.6 9
genes like me logo Genes that share compounds with GNRH2: view

Transcripts for GNRH2 Gene

mRNA/cDNA for GNRH2 Gene

(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(4) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNRH2 Gene

Gonadotropin-releasing hormone 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNRH2 Gene

No ASD Table

Relevant External Links for GNRH2 Gene

GeneLoc Exon Structure for
GNRH2
ECgene alternative splicing isoforms for
GNRH2

Expression for GNRH2 Gene

mRNA expression in normal human tissues for GNRH2 Gene

mRNA differential expression in normal tissues according to GTEx for GNRH2 Gene

This gene is overexpressed in Brain - Cerebellum (5.1) and Brain - Cerebellar Hemisphere (4.9).

SOURCE GeneReport for Unigene cluster for GNRH2 Gene Hs.129715

mRNA Expression by UniProt/SwissProt for GNRH2 Gene

O43555-GON2_HUMAN
Tissue specificity: Midbrain; expressed at significantly higher levels outside the brain (up to 30-fold), particularly in the kidney, bone marrow and prostate
genes like me logo Genes that share expressions with GNRH2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for GNRH2 Gene

Orthologs for GNRH2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for GNRH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNRH2 35
  • 97.3 (n)
  • 94.59 (a)
GNRH2 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNRH2 35
  • 74.19 (n)
  • 60.22 (a)
Species with no ortholog for GNRH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GNRH2 Gene

ENSEMBL:
Gene Tree for GNRH2 (if available)
TreeFam:
Gene Tree for GNRH2 (if available)

Paralogs for GNRH2 Gene

No data available for Paralogs for GNRH2 Gene

Variants for GNRH2 Gene

Sequence variations from dbSNP and Humsavar for GNRH2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs3761243 -- 3,042,376(+) AGGCA(A/C)CCATC upstream-variant-2KB
rs3761244 -- 3,042,535(+) TCCGC(A/G)TATTT upstream-variant-2KB
rs3761245 -- 3,042,587(+) TTTCC(A/G)GTCCC upstream-variant-2KB
rs6084237 -- 3,041,120(+) AGCTG(A/T)GATCA upstream-variant-2KB
rs6084238 -- 3,041,126(+) GATCA(C/T)GCCAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GNRH2 Gene

Variant ID Type Subtype PubMed ID
nsv912603 CNV Gain 21882294
nsv833896 CNV Loss 17160897
nsv833897 CNV Loss 17160897
nsv482064 CNV Gain 20164927

Relevant External Links for GNRH2 Gene

HapMap Linkage Disequilibrium report
GNRH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNRH2 Gene

Disorders for GNRH2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for GNRH2 Gene including...

Search for GNRH2 Gene in MalaCards »

(4) Novoseek inferred disease relationships for GNRH2 Gene

Disease -log(P) Hits PubMed IDs
medulloblastoma 54.4 3
ovarian cancer 49.1 13
tumors 0 7
cancer 0 3

Relevant External Links for GNRH2

Genetic Association Database (GAD)
GNRH2
Human Genome Epidemiology (HuGE) Navigator
GNRH2
genes like me logo Genes that share disorders with GNRH2: view

No data available for UniProtKB/Swiss-Prot for GNRH2 Gene

Publications for GNRH2 Gene

  1. Second gene for gonadotropin-releasing hormone in humans. (PMID: 9419371) White R.B. … Fernald R.D. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23
  2. The neuropeptides GnRH-II and GnRH-I are produced by human T cells and trigger laminin receptor gene expression, adhesion, chemotaxis and homing to specific organs. (PMID: 12447356) Chen A. … Levite M. (Nat. Med. 2002) 2 3 23
  3. Multi-factorial role of GnRH-I and GnRH-II in the human ovary. (PMID: 12770744) Leung P.C. … Zhu X.M. (Mol. Cell. Endocrinol. 2003) 3 23
  4. Cellular localization of gonadotropin-releasing hormone (GnRH) I and GnRH II in first-trimester human placenta and decidua. (PMID: 15001648) Chou C.S. … Leung P.C. (J. Clin. Endocrinol. Metab. 2004) 3 23
  5. Transcriptional regulation of the human GnRH II gene is mediated by a putative cAMP response element. (PMID: 11459794) Chen A. … Koch Y. (Endocrinology 2001) 3 23

Products for GNRH2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GNRH2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GNRH2
    • Block miRNA regulation of GNRH2 using miScript Target Protectors

    Sources for GNRH2 Gene

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