GNRH2 Gene
protein-coding GIFtS: 50
GCID: GC20P003038
|
|
gonadotropin-releasing hormone 2
| |
Aliases
for GNRH2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Gonadotropin-Releasing Hormone 21 2 | | Luliberin II2 | | Progonadoliberin II2 3 | | Luteinizing Hormone-Releasing Hormone II2 | | GnRH-II2 | | Progonadoliberin-21 | | LH-RHII2 | | |
Export aliases for GNRH2 gene to outside databasesPrevious GC identifers: GC20P003012 GC20P002972 GC20P003019 GC20P003033 |
Summaries
for GNRH2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GNRH2:
The protein encoded by this gene is a preproprotein that is cleaved to form a secreted 10 aa peptide hormone. Thesecreted decapeptide regulates reproduction in females by stimulating the secretion of both luteinizing- andfollicle-stimulating hormones. Three transcript variants that encode unique proproteins but the same peptide hormonehave been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: GON2_HUMAN, O43555Function: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing andfollicle-stimulating hormones
Gene Wiki entry for GNRH2
|
Genomic Views
for GNRH2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GNRH2 gene promoter:
CREB AP-1 ATF-2 deltaCREB c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for GNRH2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNRH2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13GNRH2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P003038: view genomic region
(about GC identifiers)
Start:
|
3,024,268 bp from pter |
End:
|
3,026,393 bp from pter |
Size:
|
2,126 bases |
Orientation:
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plus strand |
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Proteins
for GNRH2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GON2_HUMAN, O43555 (See
protein sequence)Recommended Name: Progonadoliberin-2 precursor Size: 120 amino acids; 12918 Da
Subcellular location: Secreted
Secondary accessions: Q14C68 Q14C69 Q9BYN9 Q9BYP0Alternative splicing: 3 isoforms: O43555-1 O43555-2 O43555-3 Explore the universe of human proteins at neXtProt for GNRH2: NX_O43555
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43555
GNRH2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001492.1 NP_847901.1 NP_847902.1
ENSEMBL proteins: ENSP00000245983 ENSP00000352003 ENSP00000369705 ENSP00000369704 ENSP00000353077 Reactome Protein details: O43555
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- | | GO:0005625 | soluble fraction |
-- | -- |
GNRH2 for ontologies About GeneDecksing
GNRH2 Antibody Products:
Assay Products for GNRH2: |
Protein
Domains /
Families
for GNRH2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GNRH2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O43555ProtoNet protein and cluster: O43555 UniProtKB/Swiss-Prot: GON2_HUMAN, O43555Similarity: Belongs to the GnRH family |
Function
for GNRH2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GON2_HUMAN, O43555Function: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing andfollicle-stimulating hormones Genatlas biochemistry entry for GNRH2:gonadotropin releasing hormone 2,mesencephalic form,expressed in midbrain,kidney,bone marrow prostate,including aGNRH-associated peptide
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNRH2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNRH2 (see all 3)
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Synthesis Service for GNRH2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNRH2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005179 | hormone activity |
IEA | -- |
GNRH2 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for GNRH2:
|
Pathways & Interactions
for GNRH2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts | | | 2 | GPCR Pathway | | | 3 | Rho Family GTPases | | | 4 | TGF-Beta Pathway | | | 5 | Nanog in Mammalian ESC Pluripotency | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/56 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNRH2 (see all 56)
5/8 
Reactome Pathways for GNRH2 (see all 8)
1 
Kegg Pathway (Kegg details for GNRH2):
GNRH2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GNRH2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/123 Interacting proteins for GNRH2 (ENSP000002459834) via UniProtKB, MINT, STRING, and/or I2D (see all 123)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
GNRH2 for ontologies About GeneDecksing
|
Drugs & Compounds
for GNRH2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GNRH2 for compounds About GeneDecksing
 Browse Tocris compounds for GNRH2
6 Novoseek chemical compound relationships for GNRH2 gene About this table
Search CenterWatch for drugs/clinical trials and news about GNRH2 / GON2
|
Transcripts
for GNRH2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GNRH2 gene (3 alternative transcripts): NM_001501.1 NM_178331.1 NM_178332.1 Unigene Cluster for GNRH2: Gonadotropin-releasing hormone 2 Hs.129715 [show with all ESTs]Unigene Representative Sequence: EL7363625 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000245983(uc002whr.1 uc010gau.1) ENST00000359100(uc002whp.1)
ENST00000380347 ENST00000380346 ENST00000359987(uc002whq.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNRH2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNRH2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): GNRH2 (NM_178331) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GNRH2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNRH2 |
Additional cDNA sequence: AF036330.1 AF190640.1 BC069362.1 BC115399.1 BC115400.1 2 DOTS entries: DT.40282805 DT.92067931 10 AceView cDNA sequences: AF190640 BC069362 AF036330 BF061974 NM_178332 BF062277 NM_001501 NM_178331 AL732156 AA864512
GeneLoc Exon Structure
|
Expression
for GNRH2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GNRH2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See GNRH2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GNRH2
SOURCE GeneReport for Unigene cluster: Hs.129715
UniProtKB/Swiss-Prot: GON2_HUMAN, O43555Tissue specificity: Midbrain; expressed at significantly higher levels outside the brain (up to 30-fold), particularlyin the kidney, bone marrow and prostate
SABiosciences Custom PCR Arrays for GNRH2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNRH2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat GNRH2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNRH2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNRH2 |
Orthologs
for GNRH2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for GNRH2 (if available)
TreeFam Gene Tree for GNRH2 (if available) |
Paralogs
for GNRH2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for GNRH2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GNRH2 (3024268 - 3026393 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GNRH2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GNRH2 |
|
Disorders
/ Diseases
for GNRH2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GNRH2 for disorders About GeneDecksing
OMIM gene information: 602352
OMIM disorders: --
13  diseases for GNRH2: About MalaCardsepithelial ovarian cancer ovarian cancer endometrial carcinoma endometrial cancer
leiomyoma infertility prostate cancer breast cancer
prostatitis carcinoma neuronitis adenocarcinoma
pancreatitis
4 Novoseek disease relationships for GNRH2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| medulloblastoma |
54.4 |
3 |
11459794 (1), 15562029 (1), 11931351 (1) |
| ovarian cancer |
49.1 |
15 |
17308117 (5), 17906381 (1), 16189183 (1), 11600588 (1) (see all 9) |
| tumors |
0 |
8 |
15380810 (2), 17906381 (1), 11600588 (1), 12770744 (1) (see all 6) |
| cancer |
0 |
3 |
17202595 (1), 18222967 (1), 17308117 (1) |
Human Genome Epidemiology (HuGE) Navigator: GNRH2 (5 documents)
Export disorders for GNRH2 gene to outside databases
|
Publications
for GNRH2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GNRH2 gene, integrated from 9 sources (see all 90):
(articles sorted by number of sources associating them with GNRH2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Second gene for gonadotropin-releasing hormone in humans. (PubMed id 9419371)1, 2, 3, 9 White R.B.... Fernald R.D. (1998)
- The neuropeptides GnRH-II and GnRH-I are produced by human T cells and trigger laminin receptor gene expression, adhesion, chemotaxis and homing to specific organs. (PubMed id 12447356)1, 3, 9 Chen A....Levite M. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Transcriptional regulation of the human GnRH II gene is mediated by a putative cAMP response element. (PubMed id 11459794)1, 9 Chen A....Koch Y. (2001)
- Cellular localization of gonadotropin-releasing hormone (GnRH) I and GnRH II in first-trimester human placenta and decidua. (PubMed id 15001648)1, 9 Chou C.S....Leung P.C. (2004)
- Expression of gonadotropin-releasing hormone type-I (GnRH-I) and type-II (GnRH-II) in human peripheral blood mononuclear cells (PMBCs) and regulation of B-lymphoblastoid cell proliferation by GnRH-I and GnRH-II. (PubMed id 15578334)1, 9 Tanriverdi F....Bouloux P.M. (2004)
- Multi-factorial role of GnRH-I and GnRH-II in the human ovary. (PubMed id 12770744)1, 9 Leung P.C....Zhu X.M. (2003)
- Human myometrium and leiomyomas express gonadotropin-releasing hormone 2 and gonadotropin-releasing hormone 2 receptor. (PubMed id 17296196)1, 9 Parker J.D....Catherino W.H. (2007)
- Differential role of progesterone receptor isoforms in the transcriptional regulation of human gonadotropin-releasing hormone I (GnRH I) receptor, GnRH I, and GnRH II. (PubMed id 15562029)1, 9 An B.S....Leung P.C. (2005)
|
External Searches for GNRH2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GNRH2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GNRH2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GNRH2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GNRH2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GNRH2 gene:
Search GeneIP for patents involving GNRH2
Licensable Technologies for GNRH2 gene:GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GNRH2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GNRH2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GNRH2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GNRH2 | | | OriGene Protein Over-expression Lysate for GNRH2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GNRH2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNRH2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNRH2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for GNRH2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GNRH2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GNRH2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNRH2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNRH2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNRH2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNRH2 |
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| |  |  |  |  | | | | |
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