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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GNRH1 Gene

protein-coding GIFtS: 62
GCID: GC08M025276

gonadotropin-releasing hormone 1 (luteinizing-releasing...

(Previous name: gonadotropin-releasing hormone 1 (leutinizing-releasing...)
(Previous symbols: GRH, GNRH, LHRH)

Explore 152 diseases affiliated with
GNRH1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Gonadotropin-Releasing Hormone 1 (Luteinizing-Releasing Hormone)¹ ²		LNRH² ⁵
GNRH¹ ² ³		HH12²
GRH¹ ² ³		GnRH-Associated Peptide 1²
LHRH¹ ² ³		Luliberin I²
Gonadotropin-Releasing Hormone 1 (Leutinizing-Releasing Hormone)¹ ²		Progonadoliberin-1¹
Progonadoliberin I² ³		Prolactin Release-Inhibiting Factor²

External Ids:	HGNC: 4419¹	Entrez Gene: 2796²	Ensembl: ENSG00000147437⁷	OMIM: 152760⁵	UniProtKB: P01148³

Export aliases for GNRH1 gene to outside databases

Previous GC identifers: GC08M025048 GC08M025630 GC08M025298 GC08M025332 GC08M023821

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GNRH1:

The protein encoded by this gene is secreted and then cleaved to form the 10 aa luteinizing hormone-releasing hormone

(LHRH, also known as gonadoliberin-1), and prolactin release-inhibiting factor (also known as GnRH-associated peptide

1). LHRH stimulates the release of luteinizing and follicle stimulating hormones, which are important for

reproduction. Mutation in this gene are associated with hypogonadotropic hypogonadism. Alternatively spliced

transcript variants have been described for this gene. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: GON1_HUMAN, P01148

Function: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and

follicle-stimulating hormones

Gene Wiki entry for GNRH1 (Gonadotropin-releasing hormone)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_167187.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GNRH1 gene promoter:
GR Sp1 AP-1 ATF-2 GR-beta CREB deltaCREB GR-alpha c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GNRH1 promoter sequence

Search SABiosciences Chromatin IP Primers for GNRH1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNRH1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21-p11.2 Ensembl cytogenetic band: 8p21.2 HGNC cytogenetic band: 8p21-p11.2

GNRH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNRH1 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M025276: view genomic region (about GC identifiers)

Start:	25,276,774 bp from pter	End:	25,282,556 bp from pter
Size:	5,783 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GON1_HUMAN, P01148 (See protein sequence)

Recommended Name: Progonadoliberin-1 precursor

Size: 92 amino acids; 10380 Da

Subcellular location: Secreted

Secondary accessions: A0AVP0

Explore the universe of human proteins at neXtProt for GNRH1: NX_P01148

GNRH1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000816.4 NP_001076580.1

ENSEMBL proteins:

ENSP00000391280 ENSP00000276414

Reactome Protein details: P01148
Human Recombinant Protein Products:

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	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005625	soluble fraction	--	--

GNRH1 for ontologies About GeneDecksing

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	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GNRH1 for domains About GeneDecksing

3 InterPro domains/families:

IPR019792 Gonadoliberin_I

IPR004079 Gonadoliberin_I_precursor

IPR002012 GnRH

Graphical View of Domain Structure for InterPro Entry P01148

ProtoNet protein and cluster: P01148

1 Blocks protein family: IPB004079 Gonadoliberin I precursor signature

UniProtKB/Swiss-Prot: GON1_HUMAN, P01148

Similarity: Belongs to the GnRH family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GON1_HUMAN, P01148

Function: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and

follicle-stimulating hormones

Genatlas biochemistry entry for GNRH1:

gonadotropin releasing hormone 1,decapeptide expressed in hypothalamus,releasing form,involved in the regulation of

reproduction,including a GNRH-associated peptide

Summary:

During embryonic development, GNRH1 as signaling molecule is secreted from the following cells: Villous Cytotrophoblast Cells in Chorionic Villus It affects the following cells: Syncytiotrophoblast Multinuclear Cells in Chorionic Villus

miRNA Products:		OriGene 3'-UTR Clone (see all 2): GNRH1 Browse MicroRNA Expression Plasmids
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		hsa-miR-1237 hsa-miR-891b
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for GNRH1

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GNRH1
		Search LifeMap BioReagents cell lines for GNRH1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNRH1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005179	hormone activity	TAS	2863757
GO:0005183	gonadotropin hormone-releasing hormone activity	IEA	--

GNRH1 for ontologies About GeneDecksing

Animal Models:
15 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Gnrh1):

cellular	digestive/alimentary	endocrine/exocrine gland	growth/size	hematopoietic system
homeostasis/metabolism	immune system	integument	liver/biliary system	nervous system
normal	renal/urinary system	reproductive system	skeleton	tumorigenesis

GNRH1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

TGF-Beta Pathway

	TGF-Beta Pathway	1.00			JAK-STAT Pathway	0.57
	MAPK Family Pathway	0.60			JNK Pathway	0.50

Nanog in Mammalian ESC Pluripotency

	Nanog in Mammalian ESC Pluripotency	1.00			14-3-3 Induced Intracellular Signaling	0.59
	GSK3 Signaling	0.61			eNOS Signaling	0.48

Pathway sources
See GeneCards unified pathways
Show all pathways

5/56 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GNRH1 (see all 56)

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

1 BioSystems Pathway for GNRH1

Nongenotropic Androgen signaling

5/8 Reactome Pathways for GNRH1 (see all 8)

	GPCR downstream signaling
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding
	Class A/1 (Rhodopsin-like receptors)

1 Kegg Pathway (Kegg details for GNRH1):

GnRH signaling pathway

GNRH1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GNRH1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/127 Interacting proteins for GNRH1 (P01148³ ENSP00000276414⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 127)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNRHR	P30968³, ENSP00000226413⁴	I2D: score=1 STRING: ENSP00000226413
MEP1A	Q16819³, ENSP00000230588⁴	I2D: score=2 STRING: ENSP00000230588
TRA2A	Q13595³, ENSP00000297071⁴	I2D: score=1 STRING: ENSP00000297071
SRSF7	Q16629³	I2D: score=1
ADRA1B	ENSP00000306662⁴	STRING: ENSP00000306662

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	8692981
GO:0007267	cell-cell signaling	TAS	1310542
GO:0007275	multicellular organismal development	IEA	--
GO:0007565	female pregnancy	IEA	--
GO:0008285	negative regulation of cell proliferation	TAS	10832105

GNRH1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GNRH1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GNRH1
UniProtKB/Swiss-Prot: GON1_HUMAN, P01148

Pharmaceutical: Available under the names Factrel (Ayerst Labs), Lutrepulse or Lutrelef (Ferring Pharmaceuticals) and

Relisorm (Serono). Used in evaluating hypothalamic-pituitary gonadotropic function

10/123 Novoseek chemical compound relationships for GNRH1 gene (see all 123) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gnrh	98.9	15911	19821328 (18), 20179668 (17), 18843661 (16), 7628381 (14) (see all 99)
cetrorelix	91.6	136	15248835 (5), 9376196 (3), 19761413 (3), 14567887 (3) (see all 70)
buserelin	89.5	103	7819707 (3), 1320049 (3), 17174489 (2), 9533651 (2) (see all 69)
ganirelix	83.3	36	15018588 (3), 15916659 (2), 10875855 (2), 15343256 (2) (see all 21)
degarelix	82.5	18	15139513 (3), 19503784 (3), 19602868 (2), 16222784 (2) (see all 11)
goserelin	82.5	65	1320049 (3), 15921744 (2), 2140542 (2), 7657737 (2) (see all 46)
leuprolide acetate	82.2	54	7819707 (2), 15237711 (2), 2106110 (1), 8209669 (1) (see all 40)
antide	81.9	44	2245840 (3), 9887238 (2), 15333605 (2), 9788600 (2) (see all 22)
leuprolide	81.9	51	7533699 (4), 1794035 (3), 17847754 (2), 19161930 (2) (see all 35)
testosterone	80.8	420	10071824 (5), 8252838 (4), 8733005 (4), 10875642 (4) (see all 99)

Search CenterWatch for drugs/clinical trials and news about GNRH1 / GON1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GNRH1 gene (2 alternative transcripts):

NM_000825.3 NM_001083111.1

Unigene Cluster for GNRH1:

Gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)

Hs.82963 [show with all ESTs]

Unigene Representative Sequence: NM_000825

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000421054 ENST00000276414(uc003xem.4 uc003xen.4)

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		hsa-miR-1237 hsa-miR-891b
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GNRH1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GNRH1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNRH1

Additional cDNA sequence:

BC067290.1 BC126437.1 BC126463.1 M12578.1 X01059.1

4 DOTS entries:

DT.107878 DT.91756513 DT.95156698 DT.75169631

24/39 AceView cDNA sequences (see all 39):

AI457202 BC067290 AW296153 AA418885 M12578 AA418886 AL706041 W05214

AI290681 BE467538 BX104967 AL047164 AI807723 AA831002 BX508951 CB269203

BF511936 NM_000825 CD517130 CF552535 BX508966 N74305 AA043996 BF511931

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GNRH1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTAAGTAT

About this image

GNRH1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Placenta

Chorionic Villus

Syncytiotrophoblast Multinuclear Cells

Extraembryonic Tissues, Placenta

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GNRH1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GNRH1

SOURCE GeneReport for Unigene cluster: Hs.82963

SABiosciences Expression via Pathway-Focused PCR Arrays including GNRH1:

Prostate Cancer in human mouse rat

Tumor Metastasis in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNRH1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for GNRH1 gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gnrh1^{1 , 5}	gonadotropin releasing hormone 1^{1, 5}	80.15(n)¹ 74.16(a)¹		14 (34.66 cM)⁵ 14714¹ NM_008145.2¹ NP_032171.1¹ 67745229⁵
chicken (Gallus gallus)	Aves	GON1_CHICK⁶	Progonadoliberin-1Gonadoliberin-1GnRH-associated p...	50(a)	1 ↔ 1	22(836798-839576)

ENSEMBL Gene Tree for GNRH1 (if available)
TreeFam Gene Tree for GNRH1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs28665283^1,2	C,F,H,	--	23821711(+)	`TCCCCC/TGGAGT`	2	--	ds500¹		6		NS NA CSA WA	810
rs79907951^1,2	C,F,	--	23823476(+)	`TTTCCA/GTTTTG`	2	--	int¹		1		WA	118
rs76986108^1,2	C,F,	--	23825403(+)	`CCCATT/CGTTTC`	2	--	int¹		1		NA	120
rs17053646^1,2	C,F,H,	--	23825599(+)	`GAATAT/CTGACA`	2	--	int¹		18		NA NS EA WA	2024
rs17790824^1,2	C,F,H,	--	23826307(+)	`TTTCTA/GTTTAT`	2	--	ut5¹ int¹		20		NA NS EA	2050
rs78322917^1,2	F,	--	23826690(+)	`AGCCTT/GTTACC`	2	--	ut5¹ int¹		1		WA	118
rs115639164^1,2	C,	--	23826727(+)	`TCCCAA/GTCTTC`	2	--	ut5¹		1		WA	118
rs34877895^1,2		--	23826973(-)	`TTTTAA/GCTGAG`	2	--	ut5¹		0	--	--	--	--
rs76428014^1,2		--	23828564(+)	`GCATAA/TTGTCA`	2	--	us2k¹		0	--	--	--	--
rs734087^1,2		--	23828863(-)	`actcaA/Cagttc`	2	--	us2k¹		2		NA	4

HapMap Linkage Disequilibrium report for GNRH1 (25276774 - 25282556 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GNRH1
1 CNV: 3727
Human Gene Mutation Database (HGMD): GNRH1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GNRH1 for disorders           About GeneDecksing

OMIM gene information: 152760
OMIM disorders: 227200
20/152 diseases for GNRH1 (see all 152):    About MalaCards

hypogonadotropism hypogonadism hypogonadotropic hypogonadism due to gnrh deficiency 21-hydroxylase deficiency

intestinal pseudo-obstruction pituitary apoplexy catamenial pneumothorax mccune albright syndrome

prader-willi syndrome adrenal hyperplasia ovarian hyperstimulation syndrome hypothalamic hamartomas

pituitary adenoma polycystic ovary syndrome short stature leydig cell tumor

gonadal dysgenesis growth hormone deficiency endogenous depression precocious puberty

3 diseases from the University of Copenhagen DISEASES database for GNRH1:

Klinefelter's syndrome Hypogonadism Acromegaly

10/92 Novoseek disease relationships for GNRH1 gene (see all 92) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
puberty precocious	86.7	108	12225246 (4), 10519330 (3), 15476332 (3), 15995342 (2) (see all 72)
kallmann syndrome	82.5	35	8706281 (2), 8792395 (1), 10548603 (1), 8770879 (1) (see all 29)
ovarian hyperstimulation syndrome	82.2	47	7502696 (3), 19688946 (2), 17462639 (2), 10796765 (1) (see all 32)
hypogonadism	78.6	57	1586105 (2), 8706281 (2), 7708535 (2), 11893524 (2) (see all 40)
polycystic ovary syndrome	76.3	67	14973957 (3), 10796718 (3), 10943580 (2), 8923867 (2) (see all 48)
puberty delayed	73.8	13	15554892 (2), 7627337 (2), 2181393 (1), 18714650 (1) (see all 10)
endometriosis	73.6	128	19892605 (5), 8163038 (4), 15656211 (4), 9564663 (3) (see all 70)
gonadotropins increased	73.2	1	10193017 (1)
infertility	69.7	43	16190907 (3), 15832483 (2), 8163038 (2), 8042461 (2) (see all 30)
uterine leiomyoma	68.9	50	8799917 (3), 10796723 (3), 11405968 (3), 1532397 (3) (see all 32)

Genetic Association Database (GAD): GNRH1
Human Genome Epidemiology (HuGE) Navigator: GNRH1 (18 documents)

Export disorders for GNRH1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for GNRH1 gene, integrated from 9 sources (see all 1721):
(articles sorted by number of sources associating them with GNRH1)

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Characterization of cDNA for precursor of human luteinizing hormone releasing hormone. (PubMed id 6090951)^{1, 2, 3} Seeburg P.H. and Adelman J.P. (1984)
Determination of sequence variation and haplotype structure for the gonadotropin-releasing hormone (GnRH) and GnRH receptor genes: investigation of role in pubertal timing. (PubMed id 15546906)^{1, 4, 9} Sedlmeyer I.L....Palmert M.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Large-scale investigation of genomic markers for severe periodontitis. (PubMed id 15490304)^{1, 4} Suzuki A....Kamoi K. (2004)
Association of a Trp16Ser variation in the gonadotropin releasing hormone signal peptide with bone mineral density, revealed by SNP-dependent PCR typing. (PubMed id 12633791)^{1, 4} Iwasaki H....Orimo H. (2003)
Characterization of single-nucleotide polymorphisms in coding regions of human genes. (PubMed id 10391209)^{1, 2} Cargill M....Lander E.S. (1999)
The complete nucleotide sequence of the human gonadotropin-releasing hormone gene. (PubMed id 2671939)^{1, 2} Hayflick J.S.... Seeburg P.H. (1989)
Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release-inhibiting factor in human and rat. (PubMed id 2867548)^{1, 2} Adelman J.P.... Seeburg P.H. (1986)
The chemical identity of the immunoreactive LHRH-like peptide biosynthesized in the human placenta. (PubMed id 6760865)^{1, 2} Tan L. and Rousseau P. (1982)
Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. (PubMed id 14594454)^{1, 9} Grundker C. and Emons G. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2796	HGNC: 4419	AceView: GNRH1	Ensembl:ENSG00000147437	euGenes: HUgn2796
ECgene: GNRH1	Kegg: 2796	H-InvDB: GNRH1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GNRH1	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Gonadotropin-releasing_hormone

Intellectual Property for GNRH1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GNRH1 gene:
Search GeneIP for patents involving GNRH1

Licensable Technologies for GNRH1 gene:

	Weizmann Institute:	"Modulation of Neurotransmitter Receptors on T-cell Membranes: a Novel Approach for Treatment of Autoimmune, Infectious and Malignant"
	Salk Institute:	Gonadotrophin Releasing Hormone (GnRH) Analogs

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GNRH1 Gene

gonadotropin-releasing hormone 1 (luteinizing-releasing...

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Primary Amenorrhea
Varicocele
Pregnancy loss
Measles
Infertility
Dysmenorrhea
Hyperinsulinemia
Premenstrual Syndrome
Azoospermia
Endometriosis
Pituitary Tumors
Puberty Delayed
Ovarian Cysts
Nasal Epithelium
FERTILITY DISORDERS
Dyspareunia
Breast Cancer
HYPOTHYROIDISM PRIMARY
recurrent endometrial cancer
Klinefelters Syndrome
Micropenis
Hypopituitarism
Uterine Bleeding
bone loss
SECONDARY AMENORRHEA
Central Diabetes Insipidus
Miscarriage
Follicular Cyst
Ovarian Cancer
Pituitary Apoplexy
Leiomyoma
OVULATION DELAYED
Hamartoma
Uterine leiomyoma
SHORT STATURE
Kallmann Syndrome
Gynecomastia
Adrenal Hyperplasia Congenital
hormone deficiency
ENDOMETRIAL CARCINOMA
prostate cancer
GONADOTROPINS INCREASED
Atresia
pituitary adenoma nonfunctioning
ENDOCRINE DISORDER
Hyperinsulinism
Hyperandrogenism
Anovulation
Cushing Syndrome
BREAST CARCINOMA
Pituitary Diseases
insulin tolerance
Hyperprolactinemia
PITUITARY ADENOMA
Prolactinoma
HYPOTHYROIDISM JUVENILE
Leiomyomatosis
uterine leiomyosarcoma
VIRILIZATION
PROSTATE CARCINOMA
Acromegaly
Testicular dysfunction
Gynecologic Diseases
hypothalamic disorder
Ovarian Failure Premature
MENSTRUAL IRREGULARITY
Endocrine Effects
Ovarian Hyperstimulation Syndrome
Single Gene Defects
Leydig Cell Tumor
Oligozoospermia
GONADAL DYSFUNCTION
Granulosa Cell Tumor
Ovarian dysfunction
UTERUS ENLARGED
Adenoma
benign prostatic hyperplasia
OVARIAN CARCINOMA
Polycystic Ovary Syndrome
Puberty Precocious
Myoma
Menorrhagia
Infertility Male
androgen suppression
Ovarian Diseases
Cryptorchidism
Oligomenorrhea
Polycystic ovaries
ENDOMETRIOSIS PELVIC
Endometrial Cancer
Hypogonadism
Choriocarcinoma

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GNRH1 Gene

gonadotropin-releasing hormone 1 (luteinizing-releasing...

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