Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GNPNAT1 Gene

Aliases for GNPNAT1 Gene

  • Glucosamine-Phosphate N-Acetyltransferase 1 2 3 5
  • Phosphoglucosamine Transacetylase 3 4
  • Phosphoglucosamine Acetylase 3 4
  • EC 2.3.1.4 4 63
  • GNA1 3 4
  • GNPNAT 3
  • Gpnat1 3

External Ids for GNPNAT1 Gene

Previous GeneCards Identifiers for GNPNAT1 Gene

  • GC14M047037
  • GC14M051231
  • GC14M051233
  • GC14M052311
  • GC14M053241
  • GC14M033402

Summaries for GNPNAT1 Gene

GeneCards Summary for GNPNAT1 Gene

GNPNAT1 (Glucosamine-Phosphate N-Acetyltransferase 1) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Synthesis of substrates in N-glycan biosythesis. GO annotations related to this gene include identical protein binding and monosaccharide binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNPNAT1 Gene

Genomics for GNPNAT1 Gene

Regulatory Elements for GNPNAT1 Gene

Promoters for GNPNAT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GNPNAT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GNPNAT1 Gene

Chromosome:
14
Start:
52,775,193 bp from pter
End:
52,791,668 bp from pter
Size:
16,476 bases
Orientation:
Minus strand

Genomic View for GNPNAT1 Gene

Genes around GNPNAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNPNAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNPNAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNPNAT1 Gene

Proteins for GNPNAT1 Gene

  • Protein details for GNPNAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EK6-GNA1_HUMAN
    Recommended name:
    Glucosamine 6-phosphate N-acetyltransferase
    Protein Accession:
    Q96EK6

    Protein attributes for GNPNAT1 Gene

    Size:
    184 amino acids
    Molecular mass:
    20749 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GNPNAT1 Gene

neXtProt entry for GNPNAT1 Gene

Proteomics data for GNPNAT1 Gene at MOPED

Selected DME Specific Peptides for GNPNAT1 Gene

Post-translational modifications for GNPNAT1 Gene

  • Ubiquitination at Lys 55
  • Modification sites at PhosphoSitePlus

Other Protein References for GNPNAT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GNPNAT1 Gene

Gene Families for GNPNAT1 Gene

Protein Domains for GNPNAT1 Gene

Suggested Antigen Peptide Sequences for GNPNAT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96EK6

UniProtKB/Swiss-Prot:

GNA1_HUMAN :
  • Contains 1 N-acetyltransferase domain.
  • Belongs to the acetyltransferase family. GNA1 subfamily.
Domain:
  • Contains 1 N-acetyltransferase domain.
Family:
  • Belongs to the acetyltransferase family. GNA1 subfamily.
genes like me logo Genes that share domains with GNPNAT1: view

Function for GNPNAT1 Gene

Molecular function for GNPNAT1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=26 uM for acetyl-coenzyme A {ECO:0000269 PubMed:18601654}; KM=97 uM for glucosamine-6-phosphate {ECO:0000269 PubMed:18601654};
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate.

Enzyme Numbers (IUBMB) for GNPNAT1 Gene

Phenotypes for GNPNAT1 Gene

genes like me logo Genes that share phenotypes with GNPNAT1: view

Animal Models for GNPNAT1 Gene

MGI Knock Outs for GNPNAT1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNPNAT1 Gene

Localization for GNPNAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNPNAT1 Gene

Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNPNAT1 Gene COMPARTMENTS Subcellular localization image for GNPNAT1 gene
Compartment Confidence
cytosol 5
endosome 3
golgi apparatus 3
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for GNPNAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
genes like me logo Genes that share ontologies with GNPNAT1: view

Pathways & Interactions for GNPNAT1 Gene

genes like me logo Genes that share pathways with GNPNAT1: view

UniProtKB/Swiss-Prot Q96EK6-GNA1_HUMAN

  • Pathway: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.

Gene Ontology (GO) - Biological Process for GNPNAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006041 glucosamine metabolic process IEA --
GO:0006048 UDP-N-acetylglucosamine biosynthetic process TAS --
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with GNPNAT1: view

No data available for SIGNOR curated interactions for GNPNAT1 Gene

Drugs & Compounds for GNPNAT1 Gene

(2) Drugs for GNPNAT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
glucosamine 6-phosphate Experimental Pharma 0
Coenzyme A Nutra 0

(2) Additional Compounds for GNPNAT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
N-Acetyl-D-Glucosamine 6-Phosphate
  • N-Acetyl-D-Glucosamine 6-Phosphate
  • N-Acetyl-D-glucosamine-6-p
  • N-Acetyl-D-glucosamine-6-phosphate
  • N-Acetyl-glucosamine-6-p
  • N-Acetyl-glucosamine-6-phosphate
102029-88-9
genes like me logo Genes that share compounds with GNPNAT1: view

Transcripts for GNPNAT1 Gene

Unigene Clusters for GNPNAT1 Gene

Glucosamine-phosphate N-acetyltransferase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNPNAT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3:

Relevant External Links for GNPNAT1 Gene

GeneLoc Exon Structure for
GNPNAT1
ECgene alternative splicing isoforms for
GNPNAT1

Expression for GNPNAT1 Gene

mRNA expression in normal human tissues for GNPNAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNPNAT1 Gene

This gene is overexpressed in Liver (x4.4).

Protein differential expression in normal tissues from HIPED for GNPNAT1 Gene

This gene is overexpressed in Skin (9.4), Liver, secretome (7.7), and Salivary gland (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNPNAT1 Gene



SOURCE GeneReport for Unigene cluster for GNPNAT1 Gene Hs.478025

genes like me logo Genes that share expression patterns with GNPNAT1: view

Protein tissue co-expression partners for GNPNAT1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GNPNAT1 Gene

Orthologs for GNPNAT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GNPNAT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GNPNAT1 35
  • 96.38 (n)
  • 99.46 (a)
GNPNAT1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNPNAT1 35
  • 96.2 (n)
  • 98.91 (a)
GNPNAT1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gnpnat1 35
  • 91.67 (n)
  • 98.37 (a)
Gnpnat1 16
Gnpnat1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GNPNAT1 35
  • 99.82 (n)
  • 100 (a)
GNPNAT1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gnpnat1 35
  • 91.3 (n)
  • 97.83 (a)
oppossum
(Monodelphis domestica)
Mammalia GNPNAT1 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNPNAT1 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves GNPNAT1 35
  • 77.11 (n)
  • 84.07 (a)
GNPNAT1 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNPNAT1 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10832 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68838 35
zebrafish
(Danio rerio)
Actinopterygii gnpnat1 35
  • 71.56 (n)
  • 77.72 (a)
gnpnat1 36
  • 78 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4489 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010769 35
  • 50.1 (n)
  • 50.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1969 35
  • 52.33 (n)
  • 48.04 (a)
CG1969 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gna-2 35
  • 52.04 (n)
  • 44.52 (a)
gna-1 36
  • 44 (a)
OneToMany
gna-2 36
  • 20 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR510W 35
  • 50.22 (n)
  • 49.35 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D07700g 35
  • 48.35 (n)
  • 41.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GNA1 36
  • 31 (a)
OneToOne
GNA1 38
GNA1 35
  • 43.28 (n)
  • 35.82 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons GNA1 35
  • 48.53 (n)
  • 42.65 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01902 35
  • 42.82 (n)
  • 34.03 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4645 36
  • 44 (a)
OneToOne
Species with no ortholog for GNPNAT1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNPNAT1 Gene

ENSEMBL:
Gene Tree for GNPNAT1 (if available)
TreeFam:
Gene Tree for GNPNAT1 (if available)

Paralogs for GNPNAT1 Gene

Pseudogenes.org Pseudogenes for GNPNAT1 Gene

genes like me logo Genes that share paralogs with GNPNAT1: view

No data available for Paralogs for GNPNAT1 Gene

Variants for GNPNAT1 Gene

Sequence variations from dbSNP and Humsavar for GNPNAT1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1140039 -- 52,776,131(-) GCAGG(A/G)GCACA utr-variant-3-prime
rs2296494 -- 52,783,575(+) TTACA(C/G)GCAAT intron-variant
rs2296497 -- 52,782,098(+) TTGGA(A/G)TATAA intron-variant
rs3193498 -- 52,777,478(-) AAATG(G/T)AGTAT utr-variant-3-prime
rs3945721 -- 52,777,536(+) GGGTA(A/G)AAACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GNPNAT1 Gene

Variant ID Type Subtype PubMed ID
nsv832796 CNV Loss 17160897
nsv470647 CNV Gain 18288195
nsv901952 CNV Loss 21882294
nsv1279 CNV Insertion 18451855
nsv819339 CNV Loss 19587683
esv2748720 CNV Deletion 23290073
esv7884 CNV Loss 19470904
esv2677927 CNV Deletion 23128226
nsv826956 CNV Loss 20364138

Variation tolerance for GNPNAT1 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 8.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNPNAT1 Gene

HapMap Linkage Disequilibrium report
GNPNAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNPNAT1 Gene

Disorders for GNPNAT1 Gene

Relevant External Links for GNPNAT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNPNAT1

No disorders were found for GNPNAT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNPNAT1 Gene

Publications for GNPNAT1 Gene

  1. Acceptor substrate binding revealed by crystal structure of human glucosamine-6-phosphate N-acetyltransferase 1. (PMID: 18675810) Wang J. … Su X.-D. (FEBS Lett. 2008) 3 4 23 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for GNPNAT1 Gene

Sources for GNPNAT1 Gene

Back to Top

Content