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Aliases for GNPNAT1 Gene

Aliases for GNPNAT1 Gene

  • Glucosamine-Phosphate N-Acetyltransferase 1 2 3 5
  • Phosphoglucosamine Transacetylase 3 4
  • Phosphoglucosamine Acetylase 3 4
  • EC 4 63
  • GNA1 3 4
  • GNPNAT 3
  • Gpnat1 3

External Ids for GNPNAT1 Gene

Previous GeneCards Identifiers for GNPNAT1 Gene

  • GC14M047037
  • GC14M051231
  • GC14M051233
  • GC14M052311
  • GC14M053241
  • GC14M033402

Summaries for GNPNAT1 Gene

GeneCards Summary for GNPNAT1 Gene

GNPNAT1 (Glucosamine-Phosphate N-Acetyltransferase 1) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Synthesis of substrates in N-glycan biosythesis. GO annotations related to this gene include identical protein binding and monosaccharide binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNPNAT1 Gene

Genomics for GNPNAT1 Gene

Regulatory Elements for GNPNAT1 Gene

Enhancers for GNPNAT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GNPNAT1 on UCSC Golden Path with GeneCards custom track

Promoters for GNPNAT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GNPNAT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GNPNAT1 Gene

52,775,193 bp from pter
52,791,668 bp from pter
16,476 bases
Minus strand

Genomic View for GNPNAT1 Gene

Genes around GNPNAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNPNAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNPNAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNPNAT1 Gene

Proteins for GNPNAT1 Gene

  • Protein details for GNPNAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glucosamine 6-phosphate N-acetyltransferase
    Protein Accession:

    Protein attributes for GNPNAT1 Gene

    184 amino acids
    Molecular mass:
    20749 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GNPNAT1 Gene

neXtProt entry for GNPNAT1 Gene

Proteomics data for GNPNAT1 Gene at MOPED

Selected DME Specific Peptides for GNPNAT1 Gene

Post-translational modifications for GNPNAT1 Gene

  • Ubiquitination at Lys 55
  • Modification sites at PhosphoSitePlus

Other Protein References for GNPNAT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GNPNAT1 Gene

Gene Families for GNPNAT1 Gene

Protein Domains for GNPNAT1 Gene

Suggested Antigen Peptide Sequences for GNPNAT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 N-acetyltransferase domain.
  • Belongs to the acetyltransferase family. GNA1 subfamily.
  • Contains 1 N-acetyltransferase domain.
  • Belongs to the acetyltransferase family. GNA1 subfamily.
genes like me logo Genes that share domains with GNPNAT1: view

Function for GNPNAT1 Gene

Molecular function for GNPNAT1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=26 uM for acetyl-coenzyme A {ECO:0000269 PubMed:18601654}; KM=97 uM for glucosamine-6-phosphate {ECO:0000269 PubMed:18601654};
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate.

Enzyme Numbers (IUBMB) for GNPNAT1 Gene

Phenotypes for GNPNAT1 Gene

genes like me logo Genes that share phenotypes with GNPNAT1: view

Animal Models for GNPNAT1 Gene

MGI Knock Outs for GNPNAT1:

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNPNAT1 Gene

Localization for GNPNAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNPNAT1 Gene

Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for GNPNAT1 Gene COMPARTMENTS Subcellular localization image for GNPNAT1 gene
Compartment Confidence
cytosol 5
endosome 3
golgi apparatus 3
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for GNPNAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
genes like me logo Genes that share ontologies with GNPNAT1: view

Pathways & Interactions for GNPNAT1 Gene

genes like me logo Genes that share pathways with GNPNAT1: view

UniProtKB/Swiss-Prot Q96EK6-GNA1_HUMAN

  • Pathway: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.

Gene Ontology (GO) - Biological Process for GNPNAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006041 glucosamine metabolic process IEA --
GO:0006048 UDP-N-acetylglucosamine biosynthetic process TAS --
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with GNPNAT1: view

No data available for SIGNOR curated interactions for GNPNAT1 Gene

Drugs & Compounds for GNPNAT1 Gene

(2) Drugs for GNPNAT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
glucosamine 6-phosphate Experimental Pharma 0
Coenzyme A Nutra 0

(2) Additional Compounds for GNPNAT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
N-Acetyl-D-Glucosamine 6-Phosphate
  • N-Acetyl-D-Glucosamine 6-Phosphate
  • N-Acetyl-D-glucosamine-6-p
  • N-Acetyl-D-glucosamine-6-phosphate
  • N-Acetyl-glucosamine-6-p
  • N-Acetyl-glucosamine-6-phosphate
genes like me logo Genes that share compounds with GNPNAT1: view

Transcripts for GNPNAT1 Gene

Unigene Clusters for GNPNAT1 Gene

Glucosamine-phosphate N-acetyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNPNAT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: -
SP2: - -

Relevant External Links for GNPNAT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GNPNAT1 Gene

mRNA expression in normal human tissues for GNPNAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNPNAT1 Gene

This gene is overexpressed in Liver (x4.4).

Protein differential expression in normal tissues from HIPED for GNPNAT1 Gene

This gene is overexpressed in Skin (9.4), Liver, secretome (7.7), and Salivary gland (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNPNAT1 Gene

SOURCE GeneReport for Unigene cluster for GNPNAT1 Gene Hs.478025

genes like me logo Genes that share expression patterns with GNPNAT1: view

Protein tissue co-expression partners for GNPNAT1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GNPNAT1 Gene

Orthologs for GNPNAT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GNPNAT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GNPNAT1 35
  • 96.38 (n)
  • 99.46 (a)
  • 99 (a)
(Canis familiaris)
Mammalia GNPNAT1 35
  • 96.2 (n)
  • 98.91 (a)
  • 99 (a)
(Mus musculus)
Mammalia Gnpnat1 35
  • 91.67 (n)
  • 98.37 (a)
Gnpnat1 16
Gnpnat1 36
  • 98 (a)
(Pan troglodytes)
Mammalia GNPNAT1 35
  • 99.82 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Gnpnat1 35
  • 91.3 (n)
  • 97.83 (a)
(Monodelphis domestica)
Mammalia GNPNAT1 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia GNPNAT1 36
  • 88 (a)
(Gallus gallus)
Aves GNPNAT1 35
  • 77.11 (n)
  • 84.07 (a)
  • 81 (a)
(Anolis carolinensis)
Reptilia GNPNAT1 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10832 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68838 35
(Danio rerio)
Actinopterygii gnpnat1 35
  • 71.56 (n)
  • 77.72 (a)
gnpnat1 36
  • 78 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4489 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010769 35
  • 50.1 (n)
  • 50.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1969 35
  • 52.33 (n)
  • 48.04 (a)
CG1969 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea gna-2 35
  • 52.04 (n)
  • 44.52 (a)
gna-1 36
  • 44 (a)
gna-2 36
  • 20 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR510W 35
  • 50.22 (n)
  • 49.35 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D07700g 35
  • 48.35 (n)
  • 41.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GNA1 35
  • 43.28 (n)
  • 35.82 (a)
GNA1 36
  • 31 (a)
GNA1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons GNA1 35
  • 48.53 (n)
  • 42.65 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01902 35
  • 42.82 (n)
  • 34.03 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4645 36
  • 44 (a)
Species with no ortholog for GNPNAT1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNPNAT1 Gene

Gene Tree for GNPNAT1 (if available)
Gene Tree for GNPNAT1 (if available)

Paralogs for GNPNAT1 Gene Pseudogenes for GNPNAT1 Gene

genes like me logo Genes that share paralogs with GNPNAT1: view

No data available for Paralogs for GNPNAT1 Gene

Variants for GNPNAT1 Gene

Sequence variations from dbSNP and Humsavar for GNPNAT1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7147149 -- 52,776,061(+) cagcc(A/G/T)catgg utr-variant-3-prime
rs3193498 -- 52,777,478(-) AAATG(G/T)AGTAT utr-variant-3-prime
rs3759645 -- 52,788,877(-) TTAAA(A/T)TTCAT intron-variant
rs3759646 -- 52,788,876(-) TAAAA(A/T)TCATT intron-variant
rs3945721 -- 52,777,536(+) GGGTA(A/G)AAACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GNPNAT1 Gene

Variant ID Type Subtype PubMed ID
nsv832796 CNV Loss 17160897
nsv470647 CNV Gain 18288195
nsv901952 CNV Loss 21882294
nsv1279 CNV Insertion 18451855
nsv819339 CNV Loss 19587683
esv2748720 CNV Deletion 23290073
esv7884 CNV Loss 19470904
esv2677927 CNV Deletion 23128226
nsv826956 CNV Loss 20364138

Variation tolerance for GNPNAT1 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 8.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GNPNAT1 Gene

Disorders for GNPNAT1 Gene

Relevant External Links for GNPNAT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GNPNAT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNPNAT1 Gene

Publications for GNPNAT1 Gene

  1. Acceptor substrate binding revealed by crystal structure of human glucosamine-6-phosphate N-acetyltransferase 1. (PMID: 18675810) Wang J. … Su X.-D. (FEBS Lett. 2008) 3 4 23 67
  2. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3

Products for GNPNAT1 Gene

Sources for GNPNAT1 Gene