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Aliases for GNPDA2 Gene

Aliases for GNPDA2 Gene

  • Glucosamine-6-Phosphate Deaminase 2 2 3 4 5
  • Glucosamine-6-Phosphate Isomerase SB52 3 4
  • GlcN6P Deaminase 2 3 4
  • EC 3.5.99.6 4 61
  • GNP2 3 4
  • Glucosamine-6-Phosphate Isomerase 2 3
  • Glucosamine-6-Phosphate Isomerase 2
  • GNPDA 2 4
  • SB52 3

External Ids for GNPDA2 Gene

Previous GeneCards Identifiers for GNPDA2 Gene

  • GC04M044619
  • GC04M044545
  • GC04M044398
  • GC04M044704
  • GC04M044025

Summaries for GNPDA2 Gene

Entrez Gene Summary for GNPDA2 Gene

  • The protein encoded by this gene is an allosteric enzyme that catalyzes the reversible reaction converting D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Variations of this gene have been reported to be associated with influencing body mass index and susceptibility to obesity. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

GeneCards Summary for GNPDA2 Gene

GNPDA2 (Glucosamine-6-Phosphate Deaminase 2) is a Protein Coding gene. Diseases associated with GNPDA2 include Obesity. Among its related pathways are Metabolism and Glucose metabolism. GO annotations related to this gene include hydrolase activity and glucosamine-6-phosphate deaminase activity. An important paralog of this gene is GNPDA1.

Gene Wiki entry for GNPDA2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNPDA2 Gene

Genomics for GNPDA2 Gene

Regulatory Elements for GNPDA2 Gene

Enhancers for GNPDA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F044764 0.4 ENCODE 40 -38.8 -38778 1.2 GNPDA2 GUF1 KCTD8 LOC105374440
GH04F044522 0.6 ENCODE 13.2 +203.2 203216 2.4 KCTD8 GNPDA2 GUF1 ENSG00000251159
GH04F044677 0.4 ENCODE 12.9 +47.6 47606 3.0 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZHX2 JUNB GUF1 GNPDA2 YIPF7 GC04M044690
GH04F044863 0.2 ENCODE 5.3 -137.3 -137306 1.6 JUND BCL11A TEAD4 POU5F1 KDM1A REST GUF1 GNPDA2 LOC100419045 LOC105374441
GH04F044725 1.1 FANTOM5 ENCODE 2.5 +0.5 486 2.2 ATF1 WRNIP1 ZFP64 SIN3A ARID4B DMAP1 ZNF48 GLIS2 GTF2B NFYC GUF1 KCTD8 GNPDA2 LOC105374439 ENSG00000272936
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GNPDA2 on UCSC Golden Path with GeneCards custom track

Promoters for GNPDA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001240339 334 2600 WRNIP1 ZFP64 SIN3A ARID4B DMAP1 ZNF48 GLIS2 GTF2B NFYC REST

Genomic Location for GNPDA2 Gene

Chromosome:
4
Start:
44,682,200 bp from pter
End:
44,726,634 bp from pter
Size:
44,435 bases
Orientation:
Minus strand

Genomic View for GNPDA2 Gene

Genes around GNPDA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNPDA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNPDA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNPDA2 Gene

Proteins for GNPDA2 Gene

  • Protein details for GNPDA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDQ7-GNPI2_HUMAN
    Recommended name:
    Glucosamine-6-phosphate isomerase 2
    Protein Accession:
    Q8TDQ7
    Secondary Accessions:
    • B4DJF3
    • Q2VYF1
    • Q59EA7
    • Q8NCZ8
    • Q96BJ4
    • Q96NC6

    Protein attributes for GNPDA2 Gene

    Size:
    276 amino acids
    Molecular mass:
    31085 Da
    Quaternary structure:
    • Homohexamer.
    SequenceCaution:
    • Sequence=BAD93141.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GNPDA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GNPDA2 Gene

Selected DME Specific Peptides for GNPDA2 Gene

Q8TDQ7:
  • NFFKHIDI
  • ALTVGVGT
  • TFNMDEYV
  • GHIAFNEP
  • LASEWAAKYICN
  • TGSTPLG
  • VNHMWTVSA
  • KTLAMDTILANA
  • FNEPGSS
  • VKTVKYFKGLM
  • VHNKLVDPL
  • HILDGNA
  • DEDATLEL
  • LFVGGIGPDGH

Post-translational modifications for GNPDA2 Gene

  • Ubiquitination at Lys 160 and Lys 172
  • Modification sites at PhosphoSitePlus

Other Protein References for GNPDA2 Gene

Antibody Products

  • Abcam antibodies for GNPDA2

Domains & Families for GNPDA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TDQ7

UniProtKB/Swiss-Prot:

GNPI2_HUMAN :
  • Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
Family:
  • Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
genes like me logo Genes that share domains with GNPDA2: view

No data available for Gene Families for GNPDA2 Gene

Function for GNPDA2 Gene

Molecular function for GNPDA2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Alpha-D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3).

Enzyme Numbers (IUBMB) for GNPDA2 Gene

Gene Ontology (GO) - Molecular Function for GNPDA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004342 glucosamine-6-phosphate deaminase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with GNPDA2: view
genes like me logo Genes that share phenotypes with GNPDA2: view

Animal Model Products

miRNA for GNPDA2 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GNPDA2 Gene

Localization for GNPDA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNPDA2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNPDA2 Gene COMPARTMENTS Subcellular localization image for GNPDA2 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GNPDA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA,IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with GNPDA2: view

Pathways & Interactions for GNPDA2 Gene

genes like me logo Genes that share pathways with GNPDA2: view

Gene Ontology (GO) - Biological Process for GNPDA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006006 glucose metabolic process TAS --
GO:0006044 N-acetylglucosamine metabolic process IEA --
GO:0006046 N-acetylglucosamine catabolic process IBA --
GO:0006048 UDP-N-acetylglucosamine biosynthetic process IBA --
genes like me logo Genes that share ontologies with GNPDA2: view

No data available for SIGNOR curated interactions for GNPDA2 Gene

Drugs & Compounds for GNPDA2 Gene

(2) Drugs for GNPDA2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
glucosamine 6-phosphate Experimental Pharma 0

(3) Additional Compounds for GNPDA2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
Fructose 6-phosphate
  • D-Fructose 6-phosphate
  • D-Fructose 6-phosphorate
  • D-Fructose 6-phosphoric acid
  • D-Fructose-6-P
  • D-Fructose-6-phosphate
643-13-0
N-Acetyl-D-Glucosamine 6-Phosphate
  • N-Acetyl-D-Glucosamine 6-Phosphate
  • N-Acetyl-D-glucosamine-6-p
  • N-Acetyl-D-glucosamine-6-phosphate
  • N-Acetyl-glucosamine-6-p
  • N-Acetyl-glucosamine-6-phosphate
102029-88-9
genes like me logo Genes that share compounds with GNPDA2: view

Transcripts for GNPDA2 Gene

mRNA/cDNA for GNPDA2 Gene

(3) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNPDA2 Gene

Glucosamine-6-phosphate deaminase 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNPDA2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP2:
SP3: - - - - -
SP4: - - - - - -
SP5: -

Relevant External Links for GNPDA2 Gene

GeneLoc Exon Structure for
GNPDA2
ECgene alternative splicing isoforms for
GNPDA2

Expression for GNPDA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GNPDA2 Gene

Protein differential expression in normal tissues from HIPED for GNPDA2 Gene

This gene is overexpressed in Ovary (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GNPDA2 Gene



Protein tissue co-expression partners for GNPDA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GNPDA2 Gene:

GNPDA2

SOURCE GeneReport for Unigene cluster for GNPDA2 Gene:

Hs.21398
genes like me logo Genes that share expression patterns with GNPDA2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GNPDA2 Gene

Orthologs for GNPDA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GNPDA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNPDA2 34 35
  • 99.88 (n)
oppossum
(Monodelphis domestica)
Mammalia GNPDA2 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNPDA2 34 35
  • 95.17 (n)
dog
(Canis familiaris)
Mammalia GNPDA2 34 35
  • 93.36 (n)
rat
(Rattus norvegicus)
Mammalia Gnpda2 34
  • 90.94 (n)
mouse
(Mus musculus)
Mammalia Gnpda2 34 16 35
  • 89.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 77 (a)
ManyToMany
chicken
(Gallus gallus)
Aves GNPDA2 34 35
  • 85.28 (n)
lizard
(Anolis carolinensis)
Reptilia GNPDA2 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gnpda2 34
  • 79.49 (n)
Str.8141 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68593 34
zebrafish
(Danio rerio)
Actinopterygii gnpda2 34 35
  • 74.45 (n)
fruit fly
(Drosophila melanogaster)
Insecta Oscillin 34 35
  • 66.67 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta GNPI_ANOGA 34
  • 63.67 (n)
worm
(Caenorhabditis elegans)
Secernentea T03F6.3 35
  • 67 (a)
OneToMany
CELE_T03F6.3 34
  • 62.14 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10232 35
  • 78 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU04727 34
  • 56.26 (n)
Species where no ortholog for GNPDA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNPDA2 Gene

ENSEMBL:
Gene Tree for GNPDA2 (if available)
TreeFam:
Gene Tree for GNPDA2 (if available)

Paralogs for GNPDA2 Gene

Paralogs for GNPDA2 Gene

(1) SIMAP similar genes for GNPDA2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for GNPDA2 Gene

genes like me logo Genes that share paralogs with GNPDA2: view

Variants for GNPDA2 Gene

Sequence variations from dbSNP and Humsavar for GNPDA2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10009805 -- 44,719,910(+) ATTTT(C/T)TTTAA intron-variant
rs10010606 -- 44,702,259(+) ACTTC(A/G)TATTA nc-transcript-variant, utr-variant-3-prime
rs10020551 -- 44,705,798(+) TTTGG(G/T)TAAGT intron-variant
rs10212824 -- 44,705,924(+) CTGGT(A/C)ATAGA intron-variant
rs10213219 -- 44,704,359(+) GGATC(A/G)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNPDA2 Gene

Variant ID Type Subtype PubMed ID
nsv1013488 CNV loss 25217958
nsv4319 CNV deletion 18451855

Variation tolerance for GNPDA2 Gene

Residual Variation Intolerance Score: 32.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNPDA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNPDA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNPDA2 Gene

Disorders for GNPDA2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GNPDA2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
obesity
  • obesity, association with
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GNPDA2

Genetic Association Database (GAD)
GNPDA2
Human Genome Epidemiology (HuGE) Navigator
GNPDA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNPDA2
genes like me logo Genes that share disorders with GNPDA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNPDA2 Gene

Publications for GNPDA2 Gene

  1. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PMID: 19851340) Hotta K. … Nakamura Y. (J. Hum. Genet. 2009) 3 22 46 64
  2. Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study. (PMID: 12965206) Arreola R. … Horjales E. (FEBS Lett. 2003) 2 3 4 64
  3. Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus. (PMID: 19910641) He M. … Qi L. (Arterioscler. Thromb. Vasc. Biol. 2010) 3 46 64
  4. Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study. (PMID: 19910938) Haupt A. … Staiger H. (Obesity (Silver Spring) 2010) 3 46 64
  5. Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. (PMID: 20215397) Ng M.C. … Ma R.C. (J. Clin. Endocrinol. Metab. 2010) 3 46 64

Products for GNPDA2 Gene

Sources for GNPDA2 Gene

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