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Aliases for GNPDA2 Gene

Aliases for GNPDA2 Gene

  • Glucosamine-6-Phosphate Deaminase 2 2 3 4 5
  • Glucosamine-6-Phosphate Isomerase SB52 3 4
  • GlcN6P Deaminase 2 3 4
  • EC 4 63
  • GNP2 3 4
  • Glucosamine-6-Phosphate Isomerase 2
  • GNPDA 2 4
  • SB52 3

External Ids for GNPDA2 Gene

Previous GeneCards Identifiers for GNPDA2 Gene

  • GC04M044619
  • GC04M044545
  • GC04M044398
  • GC04M044704
  • GC04M044025

Summaries for GNPDA2 Gene

Entrez Gene Summary for GNPDA2 Gene

  • The protein encoded by this gene is an allosteric enzyme that catalyzes the reversible reaction converting D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Variations of this gene have been reported to be associated with influencing body mass index and susceptibility to obesity. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

GeneCards Summary for GNPDA2 Gene

GNPDA2 (Glucosamine-6-Phosphate Deaminase 2) is a Protein Coding gene. Diseases associated with GNPDA2 include Obesity. Among its related pathways are Glycosaminoglycan metabolism and Amino sugar and nucleotide sugar metabolism. GO annotations related to this gene include hydrolase activity and glucosamine-6-phosphate deaminase activity. An important paralog of this gene is GNPDA1.

Gene Wiki entry for GNPDA2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNPDA2 Gene

Genomics for GNPDA2 Gene

Regulatory Elements for GNPDA2 Gene

Enhancers for GNPDA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GNPDA2 on UCSC Golden Path with GeneCards custom track

Promoters for GNPDA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GNPDA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GNPDA2 Gene

44,682,200 bp from pter
44,726,634 bp from pter
44,435 bases
Minus strand

Genomic View for GNPDA2 Gene

Genes around GNPDA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNPDA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNPDA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNPDA2 Gene

Proteins for GNPDA2 Gene

  • Protein details for GNPDA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glucosamine-6-phosphate isomerase 2
    Protein Accession:
    Secondary Accessions:
    • B4DJF3
    • Q2VYF1
    • Q59EA7
    • Q8NCZ8
    • Q96BJ4
    • Q96NC6

    Protein attributes for GNPDA2 Gene

    276 amino acids
    Molecular mass:
    31085 Da
    Quaternary structure:
    • Homohexamer.
    • Sequence=BAD93141.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GNPDA2 Gene


neXtProt entry for GNPDA2 Gene

Proteomics data for GNPDA2 Gene at MOPED

Post-translational modifications for GNPDA2 Gene

  • Ubiquitination at Lys 160 and Lys 172
  • Modification sites at PhosphoSitePlus

Other Protein References for GNPDA2 Gene

Antibody Products

Domains & Families for GNPDA2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
  • Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
genes like me logo Genes that share domains with GNPDA2: view

No data available for Gene Families for GNPDA2 Gene

Function for GNPDA2 Gene

Molecular function for GNPDA2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Alpha-D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3).

Enzyme Numbers (IUBMB) for GNPDA2 Gene

Gene Ontology (GO) - Molecular Function for GNPDA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with GNPDA2: view

Phenotypes for GNPDA2 Gene

genes like me logo Genes that share phenotypes with GNPDA2: view

Animal Model Products

miRNA for GNPDA2 Gene

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GNPDA2 Gene

Localization for GNPDA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNPDA2 Gene


Subcellular locations from

Jensen Localization Image for GNPDA2 Gene COMPARTMENTS Subcellular localization image for GNPDA2 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
cytoskeleton 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for GNPDA2 Gene

Pathways & Interactions for GNPDA2 Gene

genes like me logo Genes that share pathways with GNPDA2: view

Gene Ontology (GO) - Biological Process for GNPDA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006006 glucose metabolic process TAS --
genes like me logo Genes that share ontologies with GNPDA2: view

No data available for SIGNOR curated interactions for GNPDA2 Gene

Drugs & Compounds for GNPDA2 Gene

(1) Drugs for GNPDA2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
glucosamine 6-phosphate Experimental Pharma 0

(4) Additional Compounds for GNPDA2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
Fructose 6-phosphate
  • D-Fructose 6-phosphate
  • D-Fructose 6-phosphorate
  • D-Fructose 6-phosphoric acid
  • D-Fructose-6-P
  • D-Fructose-6-phosphate
N-Acetyl-D-Glucosamine 6-Phosphate
  • N-Acetyl-D-Glucosamine 6-Phosphate
  • N-Acetyl-D-glucosamine-6-p
  • N-Acetyl-D-glucosamine-6-phosphate
  • N-Acetyl-glucosamine-6-p
  • N-Acetyl-glucosamine-6-phosphate
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with GNPDA2: view

Transcripts for GNPDA2 Gene

mRNA/cDNA for GNPDA2 Gene

(6) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNPDA2 Gene

Glucosamine-6-phosphate deaminase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNPDA2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP3: - - - - -
SP4: - - - - - -
SP5: -

Relevant External Links for GNPDA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GNPDA2 Gene

mRNA expression in normal human tissues for GNPDA2 Gene

Protein differential expression in normal tissues from HIPED for GNPDA2 Gene

This gene is overexpressed in Ovary (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNPDA2 Gene

SOURCE GeneReport for Unigene cluster for GNPDA2 Gene Hs.21398

genes like me logo Genes that share expression patterns with GNPDA2: view

Protein tissue co-expression partners for GNPDA2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GNPDA2 Gene

Orthologs for GNPDA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GNPDA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GNPDA2 35
  • 95.17 (n)
  • 97.83 (a)
  • 98 (a)
(Canis familiaris)
Mammalia GNPDA2 35
  • 93.36 (n)
  • 98.19 (a)
  • 98 (a)
(Mus musculus)
Mammalia Gnpda2 35
  • 89.61 (n)
  • 97.1 (a)
Gnpda2 16
Gnpda2 36
  • 97 (a)
(Pan troglodytes)
Mammalia GNPDA2 35
  • 99.88 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Gnpda2 35
  • 90.94 (n)
  • 97.1 (a)
(Monodelphis domestica)
Mammalia GNPDA2 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
(Gallus gallus)
Aves GNPDA2 35
  • 85.28 (n)
  • 95.26 (a)
  • 95 (a)
(Anolis carolinensis)
Reptilia GNPDA2 36
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gnpda2 35
  • 79.49 (n)
  • 94.14 (a)
Str.8141 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68593 35
(Danio rerio)
Actinopterygii gnpda2 35
  • 74.45 (n)
  • 87.59 (a)
gnpda2 36
  • 87 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GNPI_ANOGA 35
  • 63.67 (n)
  • 78.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta Oscillin 35
  • 66.67 (n)
  • 76.78 (a)
Oscillin 36
  • 74 (a)
(Caenorhabditis elegans)
Secernentea CELE_T03F6.3 35
  • 62.14 (n)
  • 67.55 (a)
T03F6.3 36
  • 67 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04727 35
  • 56.26 (n)
  • 58.89 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10232 36
  • 78 (a)
Species with no ortholog for GNPDA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNPDA2 Gene

Gene Tree for GNPDA2 (if available)
Gene Tree for GNPDA2 (if available)

Paralogs for GNPDA2 Gene

Paralogs for GNPDA2 Gene

(1) SIMAP similar genes for GNPDA2 Gene using alignment to 3 proteins: Pseudogenes for GNPDA2 Gene

genes like me logo Genes that share paralogs with GNPDA2: view

Variants for GNPDA2 Gene

Sequence variations from dbSNP and Humsavar for GNPDA2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs17851302 - 44,711,003(+) AGTTG(A/G)CACTT nc-transcript-variant, downstream-variant-500B, reference, missense
rs2709 -- 44,704,902(-) GAACA(A/G)CTTTG intron-variant, utr-variant-3-prime
rs1124828 -- 44,711,218(+) AAAAA(A/G)AAATC intron-variant
rs1128553 -- 44,702,189(-) GTTTT(C/T)TATCT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1133648 -- 44,703,578(-) CCAGA(C/T)GAATG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GNPDA2 Gene

Variant ID Type Subtype PubMed ID
nsv4319 CNV Loss 18451855

Variation tolerance for GNPDA2 Gene

Residual Variation Intolerance Score: 32.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.74% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GNPDA2 Gene

Disorders for GNPDA2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GNPDA2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • obesity, association with
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GNPDA2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GNPDA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNPDA2 Gene

Publications for GNPDA2 Gene

  1. Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study. (PMID: 12965206) Arreola R. … Horjales E. (FEBS Lett. 2003) 2 3 4 67
  2. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PMID: 19851340) Hotta K. … Nakamura Y. (J. Hum. Genet. 2009) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. (PMID: 24861553) Wen W. … Tanaka T. (Hum. Mol. Genet. 2014) 3

Products for GNPDA2 Gene

Sources for GNPDA2 Gene