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GNPDA2 Gene

protein-coding   GIFtS: 60
GCID: GC04M044684

Glucosamine-6-Phosphate Deaminase 2

  See GNPDA2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glucosamine-6-Phosphate Deaminase 21 2 3     Glucosamine-6-Phosphate Isomerase1
GNP22 3 5     SB522
GlcN6P Deaminase 22 3     Glucosamine-6-Phosphate Isomerase 22
Glucosamine-6-Phosphate Isomerase SB522 3     GNPDA 23
EC 3.5.99.63 8     

External Ids:    HGNC: 215261   Entrez Gene: 1327892   Ensembl: ENSG000001632817   OMIM: 6132225   UniProtKB: Q8TDQ73   

Export aliases for GNPDA2 gene to outside databases

Previous GC identifers: GC04M044619 GC04M044545 GC04M044398 GC04M044704 GC04M044025


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GNPDA2 Gene:
The protein encoded by this gene is an allosteric enzyme that catalyzes the reversible reaction converting
D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Variations of this gene have been reported to
be associated with influencing body mass index and susceptibility to obesity. A pseudogene of this gene is
located on chromosome 9. Alternative splicing results in multiple transcript variants that encode different
protein isoforms. (provided by RefSeq, Aug 2012)

GeneCards Summary for GNPDA2 Gene:
GNPDA2 (glucosamine-6-phosphate deaminase 2) is a protein-coding gene. Diseases associated with GNPDA2 include obesity. GO annotations related to this gene include hydrolase activity and glucosamine-6-phosphate deaminase activity. An important paralog of this gene is GNPDA1.

Gene Wiki entry for GNPDA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006238.12  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNPDA2 gene promoter:
         c-Fos   GATA-3   AP-1   POU3F1   Pax-6   Lmo2   LCR-F1   Evi-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNPDA2 promoter sequence
   Search Chromatin IP Primers for GNPDA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNPDA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p12   Ensembl cytogenetic band:  4p12   HGNC cytogenetic band: 4p13

GNPDA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNPDA2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M044684:  view genomic region     (about GC identifiers)

Start:
44,684,217 bp from pter      End:
44,728,612 bp from pter
Size:
44,396 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GNPI2_HUMAN, Q8TDQ7 (See protein sequence)
Recommended Name: Glucosamine-6-phosphate isomerase 2  
Size: 276 amino acids; 31085 Da
Subunit: Homohexamer (By similarity)
Sequence caution: Sequence=BAD93141.1; Type=Erroneous initiation;
Secondary accessions: B4DJF3 Q2VYF1 Q59EA7 Q8NCZ8 Q96BJ4 Q96NC6
Alternative splicing: 5 isoforms:  Q8TDQ7-1   Q8TDQ7-2   Q8TDQ7-3   Q8TDQ7-4   Q8TDQ7-5   

Explore the universe of human proteins at neXtProt for GNPDA2: NX_Q8TDQ7

Explore proteomics data for GNPDA2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys67, Lys160, Lys172
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GNPDA2 (Q8TDQ7) (see all 14)
     FNEPGSS  HILDGNA  TGSTPLG  NFFKHIDI 


    See GNPDA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001257809.1  NP_001257810.1  NP_612208.1  

    ENSEMBL proteins: 
     ENSP00000477137   ENSP00000476853   ENSP00000425868   ENSP00000295448   ENSP00000427423  
     ENSP00000424061  

    GNPDA2 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for GNPDA2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR006148 Glc/Gal-6P_isomerase
     IPR004547 Glucosamine6P_isomerase
     IPR018321 Glucosamine6P_isomerase_CS

    Graphical View of Domain Structure for InterPro Entry Q8TDQ7

    ProtoNet protein and cluster: Q8TDQ7

    1 Blocks protein domain: IPB004547 Glucosamine-6-phosphate isomerase

    UniProtKB/Swiss-Prot: GNPI2_HUMAN, Q8TDQ7
    Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family


    Find genes that share domains with GNPDA2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GNPI2_HUMAN, Q8TDQ7
    Catalytic activity: Alpha-D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3)

         Enzyme Number (IUBMB): EC 3.5.99.61 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004342glucosamine-6-phosphate deaminase activity IEA--
    GO:0016787hydrolase activity IEA--
         
    Find genes that share ontologies with GNPDA2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GNPDA2
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    miRNA
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    miRTarBase miRNAs that target GNPDA2:
    hsa-mir-122-5p (MIRT023359), hsa-mir-106b-5p (MIRT020422), hsa-mir-1 (MIRT002816)

    Block miRNA regulation of human, mouse, rat GNPDA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GNPDA2 (see all 51):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-25 hsa-miR-372 hsa-miR-124 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidGNPDA2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GNPDA2

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    GenScript: all cDNA clones in your preferred vector: GNPDA2 (NM_138335)
    Sino Biological Human cDNA Clone for GNPDA2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNPDA2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNPDA2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GNPI2_HUMAN, Q8TDQ7: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    plasma membrane2
    cytoskeleton1
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with GNPDA2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GNPDA2 About    
    See pathways by source

    SuperPathContained pathways About
    1Amino sugar and nucleotide sugar metabolism
    Amino sugar and nucleotide sugar metabolism
    N-acetylglucosamine degradation I0.00
    N-acetylglucosamine degradation II0.00
    UDP-N-acetyl-D-galactosamine biosynthesis II0.00
    2Metabolism
    Metabolic pathways0.38


    Find genes that share SuperPaths with GNPDA2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for GNPDA2
        UDP-N-acetyl-D-galactosamine biosynthesis II
    N-acetylglucosamine degradation I
    N-acetylglucosamine degradation II



    2 Kegg Pathways  (Kegg details for GNPDA2):
        Amino sugar and nucleotide sugar metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GNPDA2
    Interactions:

        Search GeneGlobe Interaction Network for GNPDA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for GNPDA2 (Q8TDQ73 ENSP000002954484) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ILF2Q129053, ENSP000003550114I2D: score=1 STRING: ENSP00000355011
    GNPNAT1ENSP000002164104STRING: ENSP00000216410
    GPIENSP000003488774STRING: ENSP00000348877
    HK2ENSP000002905734STRING: ENSP00000290573
    HK3ENSP000002924324STRING: ENSP00000292432
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IEA--
    GO:0006044N-acetylglucosamine metabolic process IEA--

    Find genes that share ontologies with GNPDA2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GNPDA2 (GNPI2)

    4 HMDB Compounds for GNPDA2    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    Glucosamine 6-phosphate2-Amino-2-deoxy-D-glucose 6-phosphate (see all 14)3616-42-0--
    N-Acetyl-D-Glucosamine 6-PhosphateN-Acetyl-D-Glucosamine 6-Phosphate (see all 7)102029-88-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GNPDA2 gene (3 alternative transcripts): 
    NM_001270880.1  NM_001270881.1  NM_138335.2  

    Unigene Clusters for GNPDA2:

    Glucosamine-6-phosphate deaminase 2
    Hs.21398  [show with all ESTs], Hs.597934  [show with all ESTs]
    Unigene Representative Sequences: NM_138335, AB209904
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000608855 ENST00000609092 ENST00000507917 ENST00000295448(uc003gwy.3 uc010iga.3 uc011bzb.2)
    ENST00000507534 ENST00000509756(uc003gwz.1) ENST00000511187
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate GNPDA2 (see all 51):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-25 hsa-miR-372 hsa-miR-124 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidGNPDA2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat GNPDA2
      QuantiFast Probe-based Assays in human, mouse, rat GNPDA2

    Additional mRNA sequence: AB209904.1 

    9 DOTS entries:

    DT.443522  DT.108318  DT.97776550  DT.95144357  DT.95086266  DT.97841113  DT.91643445  DT.121219738 
    DT.121219770 

    1 AceView cDNA sequence:

    AK129655 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for GNPDA2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:                                                              -     -               
    SP2:                                                                                    
    SP3:                          -     -     -     -                 -                     
    SP4:                          -     -     -     -                 -     -               
    SP5:                          -                                                         


    ECgene alternative splicing isoforms for GNPDA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GNPDA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTAGGAGA
    GNPDA2 Expression
    About this image

    GNPDA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNPDA2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.21398 Hs.597934
        Custom PCR Arrays for GNPDA2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNPDA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GNPDA2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gnpda21 , 5 glucosamine-6-phosphate deaminase 21, 5 89.61(n)1
    97.1(a)1
      5 (37.13 cM)5
    679801  NM_001038015.11  NP_001033104.11 
     695731085 
    chicken
    (Gallus gallus)
    Aves GNPDA21 glucosamine-6-phosphate deaminase 2 85.28(n)
    95.26(a)
      422772  XM_004936067.1  XP_004936124.1 
    lizard
    (Anolis carolinensis)
    Reptilia GNPDA26
    glucosamine-6-phosphate deaminase 2
    95(a)
    1 ↔ 1
    5(102297520-102310685)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC685932 hypothetical protein MGC68593 80.64(n)    BC060461.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gnpda21 glucosamine-6-phosphate deaminase 2 74.45(n)
    87.59(a)
      556291  XM_679055.4  XP_684147.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Oscillin1 Oscillin 66.67(n)
    76.78(a)
      33783  NM_001258966.1  NP_001245895.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_T03F6.31 CELE_T03F6.3 62.14(n)
    67.55(a)
      176760  NM_067357.4  NP_499758.1 


    ENSEMBL Gene Tree for GNPDA2 (if available)
    TreeFam Gene Tree for GNPDA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GNPDA2 gene
    GNPDA12  
    1 SIMAP similar gene for GNPDA2 using alignment to 3 protein entries:     GNPI2_HUMAN (see all proteins):
    GNPDA1

    Find genes that share paralogs with GNPDA2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for GNPDA2
    PGOHUM00000250527


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GNPDA2 (see all 535)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1391930351,2
    C--44703445(+) TCAGT-/GGTTGG 5 -- ds50010--------
    rs1811476001,2
    --44703540(+) GTTTTC/GGCTCC 5 -- ds50010--------
    rs721972511,2
    C--44703582(+) CTCAACTAAG   
       CCC
    /-
    CTAAC
    5 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs1863816371,2
    --44703914(+) TATTTG/TAATAT 5 -- ut31 nc-transcript-variant0--------
    rs1892667561,2
    --44704032(+) CCACAA/GAGGCA 5 -- ut31 nc-transcript-variant0--------
    rs1478643241,2
    C--44704187(+) CACGC-/TTTA  
            
    TTTGA
    5 -- ut31 nc-transcript-variant0--------
    rs11285531,2
    C,F,O,A,H--44704206(-) GTTTTT/CTATCT 5 -- nc-transcript-variantut3124Minor allele frequency- C:0.43MN NS EA NA CSA WA 2812
    rs100106061,2
    C--44704276(+) ACTTCA/GTATTA 5 -- nc-transcript-variantut310--------
    rs1399060291,2
    C--44704278(+) TTCGTA/TTTATT 5 -- ut31 nc-transcript-variant0--------
    rs1864024831,2
    --44704422(+) GGGACA/GTGAAC 5 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for GNPDA2 (44684217 - 44728612 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GNPDA2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4319CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing GNPDA2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613222    OMIM disorders: --

    1 disease for GNPDA2:    
    About MalaCards
    obesity


    Find genes that share disorders with GNPDA2           About GenesLikeMe

    Genetic Association Database (GAD): GNPDA2
    Human Genome Epidemiology (HuGE) Navigator: GNPDA2 (24 documents)

    Export disorders for GNPDA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GNPDA2 gene, integrated from 10 sources (see all 64):
    (articles sorted by number of sources associating them with GNPDA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study. (PubMed id 12965206)1, 2, 3 Arreola R.... Horjales E. (FEBS Lett. 2003)
    2. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PubMed id 19851340)1, 4, 9 Hotta K....Nakamura Y. (J. Hum. Genet. 2009)
    3. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1, 4 Speliotes E.K....Loos R.J. (Nat. Genet. 2010)
    4. Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies. (PubMed id 20724581)1, 4 den Hoed M....Loos R.J. (Diabetes 2010)
    5. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PubMed id 20571754)1, 4 Fontaine-Bisson B....Franks P.W. (Diabetologia 2010)
    6. Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa? (PubMed id 19746409)1, 4 Brandys M.K....Adan R.A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    7. Obesity and diabetes genetic variants associated with gestational weight gain. (PubMed id 20816152)1, 4 Stuebe A.M....Siega-Riz A.M. (Am. J. Obstet. Gynecol. 2010)
    8. Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study. (PubMed id 19910938)1, 4 Haupt A....Staiger H. (Obesity (Silver Spring) 2010)
    9. Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. (PubMed id 19812171)1, 4 Li S....Loos R.J. (Am. J. Clin. Nutr. 2010)
    10. Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children. (PubMed id 20843981)1, 4 Wu L....Mi J. (Diabetes 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 132789 HGNC: 21526 AceView: GNPDA2.1 Ensembl:ENSG00000163281 euGenes: HUgn132789
    ECgene: GNPDA2 Kegg: 132789 H-InvDB: GNPDA2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GNPDA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GNPDA2 gene:
    Search GeneIP for patents involving GNPDA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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