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Aliases for GNPDA2 Gene

Aliases for GNPDA2 Gene

  • Glucosamine-6-Phosphate Deaminase 2 2 3 4
  • GNP2 3 4 6
  • Glucosamine-6-Phosphate Isomerase SB52 3 4
  • GlcN6P Deaminase 2 3 4
  • EC 3.5.99.6 4 63
  • Glucosamine-6-Phosphate Isomerase 2 3
  • Glucosamine-6-Phosphate Isomerase 2
  • GNPDA 2 4
  • SB52 3

External Ids for GNPDA2 Gene

Previous GeneCards Identifiers for GNPDA2 Gene

  • GC04M044619
  • GC04M044545
  • GC04M044398
  • GC04M044704
  • GC04M044025

Summaries for GNPDA2 Gene

Entrez Gene Summary for GNPDA2 Gene

  • The protein encoded by this gene is an allosteric enzyme that catalyzes the reversible reaction converting D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Variations of this gene have been reported to be associated with influencing body mass index and susceptibility to obesity. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

GeneCards Summary for GNPDA2 Gene

GNPDA2 (Glucosamine-6-Phosphate Deaminase 2) is a Protein Coding gene. Diseases associated with GNPDA2 include obesity. Among its related pathways are Metabolism and Amino sugar and nucleotide sugar metabolism. GO annotations related to this gene include hydrolase activity and glucosamine-6-phosphate deaminase activity. An important paralog of this gene is GNPDA1.

Gene Wiki entry for GNPDA2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNPDA2 Gene

Genomics for GNPDA2 Gene

Regulatory Elements for GNPDA2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GNPDA2 Gene

Start:
44,682,183 bp from pter
End:
44,726,634 bp from pter
Size:
44,452 bases
Orientation:
Minus strand

Genomic View for GNPDA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNPDA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNPDA2 Gene

Proteins for GNPDA2 Gene

  • Protein details for GNPDA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDQ7-GNPI2_HUMAN
    Recommended name:
    Glucosamine-6-phosphate isomerase 2
    Protein Accession:
    Q8TDQ7
    Secondary Accessions:
    • B4DJF3
    • Q2VYF1
    • Q59EA7
    • Q8NCZ8
    • Q96BJ4
    • Q96NC6

    Protein attributes for GNPDA2 Gene

    Size:
    276 amino acids
    Molecular mass:
    31085 Da
    Quaternary structure:
    • Homohexamer.
    SequenceCaution:
    • Sequence=BAD93141.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GNPDA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GNPDA2 Gene

Proteomics data for GNPDA2 Gene at MOPED

Post-translational modifications for GNPDA2 Gene

  • Ubiquitination at Lys67, Lys160, and Lys172
  • Modification sites at PhosphoSitePlus

Other Protein References for GNPDA2 Gene

Antibody Products

Domains for GNPDA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TDQ7

UniProtKB/Swiss-Prot:

GNPI2_HUMAN :
  • Q8TDQ7
Family:
  • Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
genes like me logo Genes that share domains with GNPDA2: view

No data available for Gene Families for GNPDA2 Gene

Function for GNPDA2 Gene

Molecular function for GNPDA2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Alpha-D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3)

Enzyme Numbers (IUBMB) for GNPDA2 Gene

Gene Ontology (GO) - Molecular Function for GNPDA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004342 glucosamine-6-phosphate deaminase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with GNPDA2: view

Animal Model Products

CRISPR Products

miRNA for GNPDA2 Gene

miRTarBase miRNAs that target GNPDA2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNPDA2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GNPDA2 Gene

Localization for GNPDA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNPDA2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNPDA2 Gene COMPARTMENTS Subcellular localization image for GNPDA2 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 2
cytoskeleton 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GNPDA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with GNPDA2: view

Pathways for GNPDA2 Gene

genes like me logo Genes that share pathways with GNPDA2: view

Gene Ontology (GO) - Biological Process for GNPDA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006044 N-acetylglucosamine metabolic process IEA --
genes like me logo Genes that share ontologies with GNPDA2: view

Compounds for GNPDA2 Gene

(4) HMDB Compounds for GNPDA2 Gene

Compound Synonyms Cas Number PubMed IDs
Ammonia
  • NH3
7664-41-7
Glucosamine 6-phosphate
  • 2-Amino-2-deoxy-D-glucose 6-phosphate
3616-42-0
N-Acetyl-D-Glucosamine 6-Phosphate
  • N-Acetyl-D-Glucosamine 6-Phosphate
102029-88-9
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with GNPDA2: view

Transcripts for GNPDA2 Gene

mRNA/cDNA for GNPDA2 Gene

(9) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(6) REFSEQ mRNAs :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GNPDA2 Gene

Glucosamine-6-phosphate deaminase 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNPDA2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNPDA2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP2:
SP3: - - - - -
SP4: - - - - - -
SP5: -

Relevant External Links for GNPDA2 Gene

GeneLoc Exon Structure for
GNPDA2
ECgene alternative splicing isoforms for
GNPDA2

Expression for GNPDA2 Gene

mRNA expression in normal human tissues for GNPDA2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNPDA2 Gene

SOURCE GeneReport for Unigene cluster for GNPDA2 Gene Hs.21398

genes like me logo Genes that share expressions with GNPDA2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GNPDA2 Gene

Orthologs for GNPDA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GNPDA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNPDA2 35
  • 99.88 (n)
  • 100 (a)
GNPDA2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNPDA2 35
  • 95.17 (n)
  • 97.83 (a)
GNPDA2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNPDA2 35
  • 93.36 (n)
  • 98.19 (a)
GNPDA2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gnpda2 35
  • 89.61 (n)
  • 97.1 (a)
Gnpda2 16
Gnpda2 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNPDA2 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Gnpda2 35
  • 90.94 (n)
  • 97.1 (a)
chicken
(Gallus gallus)
Aves GNPDA2 35
  • 85.28 (n)
  • 95.26 (a)
GNPDA2 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNPDA2 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68593 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gnpda2 35
  • 79.49 (n)
  • 94.14 (a)
Str.8141 35
zebrafish
(Danio rerio)
Actinopterygii gnpda2 35
  • 74.45 (n)
  • 87.59 (a)
gnpda2 36
  • 87 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta GNPI_ANOGA 35
  • 63.67 (n)
  • 78.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta Oscillin 35
  • 66.67 (n)
  • 76.78 (a)
Oscillin 36
  • 74 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_T03F6.3 35
  • 62.14 (n)
  • 67.55 (a)
T03F6.3 36
  • 67 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU04727 35
  • 56.26 (n)
  • 58.89 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10232 36
  • 78 (a)
OneToMany
Species with no ortholog for GNPDA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNPDA2 Gene

ENSEMBL:
Gene Tree for GNPDA2 (if available)
TreeFam:
Gene Tree for GNPDA2 (if available)

Paralogs for GNPDA2 Gene

Paralogs for GNPDA2 Gene

Selected SIMAP similar genes for GNPDA2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for GNPDA2 Gene

genes like me logo Genes that share paralogs with GNPDA2: view

Variants for GNPDA2 Gene

Sequence variations from dbSNP and Humsavar for GNPDA2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs2709 -- 44,704,902(-) GAACA(A/G)CTTTG intron-variant, utr-variant-3-prime
rs1105272 -- 44,725,743(-) AAGGC(C/G)ACAAT intron-variant
rs1110291 -- 44,725,101(+) GCATG(C/T)TATTT intron-variant
rs1110292 -- 44,725,211(+) AATCA(C/T)TTGTC intron-variant
rs1110293 -- 44,725,391(+) TGCTA(A/G)TTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNPDA2 Gene

Variant ID Type Subtype PubMed ID
nsv4319 CNV Loss 18451855

Relevant External Links for GNPDA2 Gene

HapMap Linkage Disequilibrium report
GNPDA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNPDA2 Gene

Disorders for GNPDA2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for GNPDA2 Gene including...

Search for GNPDA2 Gene in MalaCards »

Relevant External Links for GNPDA2

Genetic Association Database (GAD)
GNPDA2
Human Genome Epidemiology (HuGE) Navigator
GNPDA2
genes like me logo Genes that share disorders with GNPDA2: view

No data available for UniProtKB/Swiss-Prot for GNPDA2 Gene

Publications for GNPDA2 Gene

  1. Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study. (PMID: 12965206) Arreola R. … Horjales E. (FEBS Lett. 2003) 2 3 4
  2. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PMID: 19851340) Hotta K. … Nakamura Y. (J. Hum. Genet. 2009) 3 23 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. (PMID: 19079261) Willer C.J. … Hirschhorn J.N. (Nat. Genet. 2009) 3 48
  5. Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. (PMID: 19164386) RenstrAPm F. … Franks P.W. (Hum. Mol. Genet. 2009) 3 48

Products for GNPDA2 Gene

Sources for GNPDA2 Gene

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