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Aliases for GNPDA1 Gene

Aliases for GNPDA1 Gene

  • Glucosamine-6-Phosphate Deaminase 1 2 3 4 5
  • Oscillin 2 3 4
  • GlcN6P Deaminase 1 3 4
  • EC 3.5.99.6 4 61
  • GNPDA 1 3 4
  • GNPI 3 4
  • HLN 3 4
  • Glucosamine-6-Phosphate Isomerase 1 3
  • Glucosamine-6-Phosphate Deaminase 2
  • Glucosamine-6-Phosphate Isomerase 2
  • KIAA0060 4
  • GNPDA 3
  • GNP1 3
  • GPI 3

External Ids for GNPDA1 Gene

Previous HGNC Symbols for GNPDA1 Gene

  • GNPI

Previous GeneCards Identifiers for GNPDA1 Gene

  • GC05M141408
  • GC05M141360
  • GC05M136526

Summaries for GNPDA1 Gene

Entrez Gene Summary for GNPDA1 Gene

  • Glucosamine-6-phosphate deaminase (EC 3.5.99.6) is an allosteric enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium (Arreola et al., 2003 [PubMed 12965206]).[supplied by OMIM, Jan 2010]

GeneCards Summary for GNPDA1 Gene

GNPDA1 (Glucosamine-6-Phosphate Deaminase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Glucose metabolism. GO annotations related to this gene include hydrolase activity and glucosamine-6-phosphate deaminase activity. An important paralog of this gene is GNPDA2.

UniProtKB/Swiss-Prot for GNPDA1 Gene

  • Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).

Gene Wiki entry for GNPDA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNPDA1 Gene

Genomics for GNPDA1 Gene

Regulatory Elements for GNPDA1 Gene

Enhancers for GNPDA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F141992 0.5 ENCODE 13 +20.5 20505 0.2 CTCF ZNF654 TRIM22 REST ZNF2 RAD21 MEF2D SMC3 HMBOX1 ZNF391 RNF14 GNPDA1 KIAA0141 LOC101926941 SPRY4 ENSG00000254099 GC05M141915
GH05F142052 0.7 Ensembl ENCODE 11.9 -40.6 -40560 1.6 ETV1 ZNF223 INSM2 ZEB1 RFX5 GATA3 FOS ZNF600 MAFK ZBTB20 GNPDA1 NDFIP1 FCHSD1 HDAC3 RELL2 MRPL11P2 LOC105378204
GH05F142057 0.4 ENCODE 11.9 -45.2 -45152 1.8 MAX FEZF1 GTF3C2 ZNF316 GATA3 POLR3A NFE2 TCF7L2 STAT1 CEBPB NDFIP1 HDAC3 LOC102723915 GNPDA1 PCDH12 RNF14 MRPL11P2 LOC105378204
GH05F142048 0.6 ENCODE 11.7 -35.4 -35426 0.1 CTCF TEAD4 RAD21 GNPDA1 MRPL11P2 LOC105378204
GH05F142134 0.5 Ensembl 11.3 -121.1 -121146 0.4 RFX1 MTA2 CBFB BHLHE40 CHD4 SIN3A TRIM22 BMI1 RAD21 NR2F2 NDFIP1 GNPDA1 ENSG00000280047
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GNPDA1 on UCSC Golden Path with GeneCards custom track

Promoters for GNPDA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001414569 155 1401 CREB3L1 MLX ARID4B SIN3A DMAP1 GLIS2 ELK1 ZNF143 FOS ZNF263

Genomic Location for GNPDA1 Gene

Chromosome:
5
Start:
141,991,749 bp from pter
End:
142,013,055 bp from pter
Size:
21,307 bases
Orientation:
Minus strand

Genomic View for GNPDA1 Gene

Genes around GNPDA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNPDA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNPDA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNPDA1 Gene

Proteins for GNPDA1 Gene

  • Protein details for GNPDA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46926-GNPI1_HUMAN
    Recommended name:
    Glucosamine-6-phosphate isomerase 1
    Protein Accession:
    P46926
    Secondary Accessions:
    • B7Z3X4
    • D3DQE7

    Protein attributes for GNPDA1 Gene

    Size:
    289 amino acids
    Molecular mass:
    32669 Da
    Quaternary structure:
    • Homohexamer.
    SequenceCaution:
    • Sequence=BAA06544.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GNPDA1 Gene

    Alternative splice isoforms for GNPDA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GNPDA1 Gene

Selected DME Specific Peptides for GNPDA1 Gene

P46926:
  • NFFKHIDI
  • SRTRVKTL
  • ALTVGVGT
  • TFNMDEYV
  • GHIAFNEP
  • HPESYHSFM
  • TGSTPLG
  • VNHMWTVSA
  • KTLAMDTILANA
  • ELKVKTVKYF
  • FNEPGSS
  • VKTVKYFKGLM
  • VHNKLVDPL
  • SFMWNNFF
  • HILDGNA
  • DEDATLEL
  • LFVGGIGPDGH

Post-translational modifications for GNPDA1 Gene

  • Ubiquitination at Lys 256 and Lys 264
  • Modification sites at PhosphoSitePlus

Domains & Families for GNPDA1 Gene

Suggested Antigen Peptide Sequences for GNPDA1 Gene

Graphical View of Domain Structure for InterPro Entry

P46926

UniProtKB/Swiss-Prot:

GNPI1_HUMAN :
  • Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
Family:
  • Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
genes like me logo Genes that share domains with GNPDA1: view

No data available for Gene Families for GNPDA1 Gene

Function for GNPDA1 Gene

Molecular function for GNPDA1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Alpha-D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3).
UniProtKB/Swiss-Prot Function:
Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).

Enzyme Numbers (IUBMB) for GNPDA1 Gene

Gene Ontology (GO) - Molecular Function for GNPDA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004342 glucosamine-6-phosphate deaminase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with GNPDA1: view
genes like me logo Genes that share phenotypes with GNPDA1: view

Animal Models for GNPDA1 Gene

MGI Knock Outs for GNPDA1:

Animal Model Products

  • Taconic Biosciences Mouse Models for GNPDA1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNPDA1 Gene

Localization for GNPDA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNPDA1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNPDA1 Gene COMPARTMENTS Subcellular localization image for GNPDA1 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for GNPDA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,ISS --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GNPDA1: view

Pathways & Interactions for GNPDA1 Gene

genes like me logo Genes that share pathways with GNPDA1: view

Gene Ontology (GO) - Biological Process for GNPDA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006006 glucose metabolic process TAS --
GO:0006043 glucosamine catabolic process IMP 9438414
GO:0006044 N-acetylglucosamine metabolic process IEA --
GO:0006046 N-acetylglucosamine catabolic process IBA --
genes like me logo Genes that share ontologies with GNPDA1: view

No data available for SIGNOR curated interactions for GNPDA1 Gene

Drugs & Compounds for GNPDA1 Gene

(8) Drugs for GNPDA1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
glucosamine 6-phosphate Experimental Pharma 0
16g Experimental Pharma Target 0
2-Deoxy-2-Amino Glucitol-6-Phosphate Experimental Pharma Target 0
Beta-D-Glucose Experimental Pharma Target 0

(6) Additional Compounds for GNPDA1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
Fructose 6-phosphate
  • D-Fructose 6-phosphate
  • D-Fructose 6-phosphorate
  • D-Fructose 6-phosphoric acid
  • D-Fructose-6-P
  • D-Fructose-6-phosphate
643-13-0
N-Acetyl-D-Glucosamine 6-Phosphate
  • N-Acetyl-D-Glucosamine 6-Phosphate
  • N-Acetyl-D-glucosamine-6-p
  • N-Acetyl-D-glucosamine-6-phosphate
  • N-Acetyl-glucosamine-6-p
  • N-Acetyl-glucosamine-6-phosphate
102029-88-9
genes like me logo Genes that share compounds with GNPDA1: view

Transcripts for GNPDA1 Gene

Unigene Clusters for GNPDA1 Gene

Glucosamine-6-phosphate deaminase 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNPDA1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c
SP1: -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - -
SP6: -
SP7: - -
SP8: - - -
SP9: - - - - - - -
SP10: - - - -
SP11: - - -
SP12: - - -
SP13: - - - - -
SP14: - -

Relevant External Links for GNPDA1 Gene

GeneLoc Exon Structure for
GNPDA1
ECgene alternative splicing isoforms for
GNPDA1

Expression for GNPDA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GNPDA1 Gene

Protein differential expression in normal tissues from HIPED for GNPDA1 Gene

This gene is overexpressed in Spleen (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GNPDA1 Gene



Protein tissue co-expression partners for GNPDA1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GNPDA1 Gene:

GNPDA1

SOURCE GeneReport for Unigene cluster for GNPDA1 Gene:

Hs.633853
genes like me logo Genes that share expression patterns with GNPDA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GNPDA1 Gene

Orthologs for GNPDA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GNPDA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNPDA1 34 35
  • 99.77 (n)
cow
(Bos Taurus)
Mammalia GNPDA1 34 35
  • 94.12 (n)
dog
(Canis familiaris)
Mammalia GNPDA1 34 35
  • 92.27 (n)
rat
(Rattus norvegicus)
Mammalia Gnpda1 34
  • 90.43 (n)
mouse
(Mus musculus)
Mammalia Gnpda1 34 16 35
  • 90.31 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 90 (a)
OneToMany
-- 35
  • 89 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 81 (a)
OneToMany
-- 35
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves GNPDA1 35
  • 91 (a)
OneToMany
-- 35
  • 85 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia GNPDA1 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gnpda1 34
  • 77.85 (n)
zebrafish
(Danio rerio)
Actinopterygii gnpda1 34 35
  • 78.78 (n)
Dr.18431 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10253 34
fruit fly
(Drosophila melanogaster)
Insecta Oscillin 35
  • 73 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T03F6.3 35
  • 69 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10232 35
  • 79 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.654 34
Species where no ortholog for GNPDA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNPDA1 Gene

ENSEMBL:
Gene Tree for GNPDA1 (if available)
TreeFam:
Gene Tree for GNPDA1 (if available)

Paralogs for GNPDA1 Gene

Paralogs for GNPDA1 Gene

(1) SIMAP similar genes for GNPDA1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with GNPDA1: view

Variants for GNPDA1 Gene

Sequence variations from dbSNP and Humsavar for GNPDA1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10214150 -- 142,010,515(+) tcttt(C/T)ttttt intron-variant
rs10628648 -- 142,009,059(+) AAAAA(-/GT/GTGTGT)GTGTG intron-variant
rs108593 -- 142,007,073(-) cttca(C/T)cagcc intron-variant
rs111251610 -- 142,003,747(+) CCATT(A/T)TCTGG intron-variant
rs111260079 -- 142,000,328(+) ACTTT(-/A/AA/AAA)TAAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for GNPDA1 Gene

Variant ID Type Subtype PubMed ID
nsv1154058 CNV deletion 26484159
nsv5036 CNV insertion 18451855
nsv511116 OTHER complex 20534489

Variation tolerance for GNPDA1 Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNPDA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNPDA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNPDA1 Gene

Disorders for GNPDA1 Gene

Relevant External Links for GNPDA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNPDA1

No disorders were found for GNPDA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNPDA1 Gene

Publications for GNPDA1 Gene

  1. The human glucosamine-6-phosphate deaminase gene: cDNA cloning and expression, genomic organization and chromosomal localization. (PMID: 9714720) Shevchenko V. … Lai F.A. (Gene 1998) 2 3 4 22 64
  2. Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study. (PMID: 12965206) Arreola R. … Horjales E. (FEBS Lett. 2003) 3 4 22 64
  3. Molecularly cloned mammalian glucosamine-6-phosphate deaminase localizes to transporting epithelium and lacks oscillin activity. (PMID: 9438414) Wolosker H. … Snyder S.H. (FASEB J. 1998) 2 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4 64

Products for GNPDA1 Gene

Sources for GNPDA1 Gene

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