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Aliases for GNPDA1 Gene

Aliases for GNPDA1 Gene

  • Glucosamine-6-Phosphate Deaminase 1 2 3 4 5
  • Oscillin 2 3 4
  • GlcN6P Deaminase 1 3 4
  • EC 4 63
  • GNPDA 1 3 4
  • GNPI 3 4
  • HLN 3 4
  • Glucosamine-6-Phosphate Deaminase 2
  • Glucosamine-6-Phosphate Isomerase 2
  • KIAA0060 4
  • GNPDA 3
  • GNP1 3
  • GPI 3

External Ids for GNPDA1 Gene

Previous HGNC Symbols for GNPDA1 Gene

  • GNPI

Previous GeneCards Identifiers for GNPDA1 Gene

  • GC05M141408
  • GC05M141360
  • GC05M136526

Summaries for GNPDA1 Gene

Entrez Gene Summary for GNPDA1 Gene

  • Glucosamine-6-phosphate deaminase (EC is an allosteric enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium (Arreola et al., 2003 [PubMed 12965206]).[supplied by OMIM, Jan 2010]

GeneCards Summary for GNPDA1 Gene

GNPDA1 (Glucosamine-6-Phosphate Deaminase 1) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Amino sugar and nucleotide sugar metabolism. GO annotations related to this gene include hydrolase activity and glucosamine-6-phosphate deaminase activity. An important paralog of this gene is GNPDA2.

UniProtKB/Swiss-Prot for GNPDA1 Gene

  • Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).

Gene Wiki entry for GNPDA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNPDA1 Gene

Genomics for GNPDA1 Gene

Regulatory Elements for GNPDA1 Gene

Enhancers for GNPDA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GNPDA1 on UCSC Golden Path with GeneCards custom track

Promoters for GNPDA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GNPDA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GNPDA1 Gene

141,991,749 bp from pter
142,013,055 bp from pter
21,307 bases
Minus strand

Genomic View for GNPDA1 Gene

Genes around GNPDA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNPDA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNPDA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNPDA1 Gene

Proteins for GNPDA1 Gene

  • Protein details for GNPDA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glucosamine-6-phosphate isomerase 1
    Protein Accession:
    Secondary Accessions:
    • B7Z3X4
    • D3DQE7

    Protein attributes for GNPDA1 Gene

    289 amino acids
    Molecular mass:
    32669 Da
    Quaternary structure:
    • Homohexamer.
    • Sequence=BAA06544.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GNPDA1 Gene

    Alternative splice isoforms for GNPDA1 Gene


neXtProt entry for GNPDA1 Gene

Proteomics data for GNPDA1 Gene at MOPED

Post-translational modifications for GNPDA1 Gene

  • Ubiquitination at Lys 256 and Lys 264
  • Modification sites at PhosphoSitePlus

Domains & Families for GNPDA1 Gene

Suggested Antigen Peptide Sequences for GNPDA1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
  • Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
genes like me logo Genes that share domains with GNPDA1: view

No data available for Gene Families for GNPDA1 Gene

Function for GNPDA1 Gene

Molecular function for GNPDA1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Alpha-D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3).
UniProtKB/Swiss-Prot Function:
Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).

Enzyme Numbers (IUBMB) for GNPDA1 Gene

Gene Ontology (GO) - Molecular Function for GNPDA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with GNPDA1: view
genes like me logo Genes that share phenotypes with GNPDA1: view

Animal Models for GNPDA1 Gene

MGI Knock Outs for GNPDA1:

Animal Model Products

  • Taconic Biosciences Mouse Models for GNPDA1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNPDA1 Gene

Localization for GNPDA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNPDA1 Gene


Subcellular locations from

Jensen Localization Image for GNPDA1 Gene COMPARTMENTS Subcellular localization image for GNPDA1 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for GNPDA1 Gene

Pathways & Interactions for GNPDA1 Gene

genes like me logo Genes that share pathways with GNPDA1: view

Gene Ontology (GO) - Biological Process for GNPDA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006091 generation of precursor metabolites and energy IMP 9438414
genes like me logo Genes that share ontologies with GNPDA1: view

No data available for SIGNOR curated interactions for GNPDA1 Gene

Drugs & Compounds for GNPDA1 Gene

(6) Drugs for GNPDA1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
glucosamine 6-phosphate Experimental Pharma 0
16g Experimental Pharma Target 0
2-Deoxy-2-Amino Glucitol-6-Phosphate Experimental Pharma Target 0
Beta-D-Glucose Experimental Pharma Target 0
calcium Nutra 0

(8) Additional Compounds for GNPDA1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
Fructose 6-phosphate
  • D-Fructose 6-phosphate
  • D-Fructose 6-phosphorate
  • D-Fructose 6-phosphoric acid
  • D-Fructose-6-P
  • D-Fructose-6-phosphate
N-Acetyl-D-Glucosamine 6-Phosphate
  • N-Acetyl-D-Glucosamine 6-Phosphate
  • N-Acetyl-D-glucosamine-6-p
  • N-Acetyl-D-glucosamine-6-phosphate
  • N-Acetyl-glucosamine-6-p
  • N-Acetyl-glucosamine-6-phosphate
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with GNPDA1: view

Transcripts for GNPDA1 Gene

Unigene Clusters for GNPDA1 Gene

Glucosamine-6-phosphate deaminase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNPDA1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c
SP1: -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - -
SP6: -
SP7: - -
SP8: - - -
SP9: - - - - - - -
SP10: - - - -
SP11: - - -
SP12: - - -
SP13: - - - - -
SP14: - -

Relevant External Links for GNPDA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GNPDA1 Gene

mRNA expression in normal human tissues for GNPDA1 Gene

Protein differential expression in normal tissues from HIPED for GNPDA1 Gene

This gene is overexpressed in Spleen (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNPDA1 Gene

SOURCE GeneReport for Unigene cluster for GNPDA1 Gene Hs.633853

genes like me logo Genes that share expression patterns with GNPDA1: view

Protein tissue co-expression partners for GNPDA1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GNPDA1 Gene

Orthologs for GNPDA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GNPDA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GNPDA1 35
  • 94.12 (n)
  • 97.92 (a)
  • 98 (a)
(Canis familiaris)
Mammalia GNPDA1 35
  • 92.27 (n)
  • 94.81 (a)
  • 95 (a)
(Mus musculus)
Mammalia Gnpda1 35
  • 90.31 (n)
  • 96.19 (a)
Gnpda1 16
Gnpda1 36
  • 96 (a)
(Pan troglodytes)
Mammalia GNPDA1 35
  • 99.77 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Gnpda1 35
  • 90.43 (n)
  • 95.85 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 89 (a)
-- 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
-- 36
  • 69 (a)
(Gallus gallus)
Aves -- 36
  • 85 (a)
  • 91 (a)
(Anolis carolinensis)
Reptilia GNPDA1 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gnpda1 35
  • 77.85 (n)
  • 89.62 (a)
(Danio rerio)
Actinopterygii Dr.18431 35
gnpda1 35
  • 78.78 (n)
  • 87.27 (a)
gnpda1 36
  • 83 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10253 35
fruit fly
(Drosophila melanogaster)
Insecta Oscillin 36
  • 73 (a)
(Caenorhabditis elegans)
Secernentea T03F6.3 36
  • 69 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.654 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10232 36
  • 79 (a)
Species with no ortholog for GNPDA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNPDA1 Gene

Gene Tree for GNPDA1 (if available)
Gene Tree for GNPDA1 (if available)

Paralogs for GNPDA1 Gene

Paralogs for GNPDA1 Gene

(1) SIMAP similar genes for GNPDA1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with GNPDA1: view

Variants for GNPDA1 Gene

Sequence variations from dbSNP and Humsavar for GNPDA1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs7408 -- 142,000,783(-) CCAGT(A/G)TTTTG utr-variant-3-prime
rs108593 -- 142,007,073(-) cttca(C/T)cagcc intron-variant
rs164080 -- 142,011,967(-) AACCG(C/T)ATCAT reference, synonymous-codon
rs1134940 -- 142,011,181(-) atgtt(A/G)gactt intron-variant
rs164500 -- 142,014,409(-) AGCGC(C/T)TGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GNPDA1 Gene

Variant ID Type Subtype PubMed ID
nsv511116 CNV Complex 20534489
nsv5036 CNV Insertion 18451855

Variation tolerance for GNPDA1 Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GNPDA1 Gene

Disorders for GNPDA1 Gene

Relevant External Links for GNPDA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GNPDA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNPDA1 Gene

Publications for GNPDA1 Gene

  1. The human glucosamine-6-phosphate deaminase gene: cDNA cloning and expression, genomic organization and chromosomal localization. (PMID: 9714720) Shevchenko V. … Lai F.A. (Gene 1998) 2 3 4 23 67
  2. Cloning and functional characterization of GNPI2, a novel human homolog of glucosamine-6-phosphate isomerase/oscillin. (PMID: 12616532) Zhang J. … Cao X. (J. Cell. Biochem. 2003) 3 23
  3. Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study. (PMID: 12965206) Arreola R. … Horjales E. (FEBS Lett. 2003) 3 23
  4. Evolution, structure, and expression of GNPI/Oscillin orthologous genes. (PMID: 10964516) Nakamura Y. … Yamanaka S. (Genomics 2000) 3 23
  5. Molecularly cloned mammalian glucosamine-6-phosphate deaminase localizes to transporting epithelium and lacks oscillin activity. (PMID: 9438414) Wolosker H. … Snyder S.H. (FASEB J. 1998) 2 3

Products for GNPDA1 Gene

Sources for GNPDA1 Gene