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Aliases for GNPDA1 Gene

Aliases for GNPDA1 Gene

  • Glucosamine-6-Phosphate Deaminase 1 2 3 4 5
  • Oscillin 2 3 4
  • GlcN6P Deaminase 1 3 4
  • EC 3.5.99.6 4 58
  • GNPDA 1 3 4
  • GNPI 3 4
  • HLN 3 4
  • Glucosamine-6-Phosphate Isomerase 1 3
  • Glucosamine-6-Phosphate Deaminase 2
  • Glucosamine-6-Phosphate Isomerase 2
  • KIAA0060 4
  • GNPDA 3
  • GNP1 3
  • GPI 3

External Ids for GNPDA1 Gene

Previous HGNC Symbols for GNPDA1 Gene

  • GNPI

Previous GeneCards Identifiers for GNPDA1 Gene

  • GC05M141408
  • GC05M141360
  • GC05M136526

Summaries for GNPDA1 Gene

Entrez Gene Summary for GNPDA1 Gene

  • Glucosamine-6-phosphate deaminase (EC 3.5.99.6) is an allosteric enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium (Arreola et al., 2003 [PubMed 12965206]).[supplied by OMIM, Jan 2010]

GeneCards Summary for GNPDA1 Gene

GNPDA1 (Glucosamine-6-Phosphate Deaminase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Amino sugar and nucleotide sugar metabolism. GO annotations related to this gene include hydrolase activity and glucosamine-6-phosphate deaminase activity. An important paralog of this gene is GNPDA2.

UniProtKB/Swiss-Prot for GNPDA1 Gene

  • Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).

Gene Wiki entry for GNPDA1 Gene

Additional gene information for GNPDA1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNPDA1 Gene

Genomics for GNPDA1 Gene

Regulatory Elements for GNPDA1 Gene

Enhancers for GNPDA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H142011 1.7 FANTOM5 ENCODE dbSUPER 19.1 -1.4 -1374 5 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 FOS SP3 GNPDA1 PCDHB18P KIAA0141 PCDHGA6 ENSG00000271871 PCDHGA7 PCDH12 DIAPH1 MRPL11P2
GH05H142355 2 FANTOM5 Ensembl ENCODE dbSUPER 10 -347.6 -347573 9 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 FCHSD1 ARHGAP26 SPRY4 SPRY4-AS1 HDAC3 PCDHGA6 GNPDA1 PCDHGA7 LOC102723915 LINC01844
GH05H141557 1.5 Ensembl ENCODE dbSUPER 10 +453.6 453551 4 PKNOX1 ATF1 SIN3A YY1 ETS1 ZNF766 ZNF143 ZNF207 FOS ATF7 PCDHGA6 PCDHA2 PCDHB18P PCDHA7 PCDHGA7 GNPDA1 PCDHA3 SLC35A4 RELL2 DIAPH1
GH05H142104 1.3 ENCODE dbSUPER 11.2 -94.3 -94349 6 PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 CBX5 JUNB REST ZNF592 NDFIP1 GNPDA1 TAF7 PCDHGA6 ENSG00000271871 PCDHB18P GC05P142103
GH05H141691 1.3 Ensembl ENCODE 10.2 +321.0 321038 1 ARNT ARID4B SIN3A ZNF2 ZNF766 ZNF143 ZNF207 DEK SP3 ZC3H11A RNF14 PCDH12 PCDH1 FCHSD1 HDAC3 RELL2 KIAA0141 GNPDA1 ARAP3 ENSG00000278925
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GNPDA1 on UCSC Golden Path with GeneCards custom track

Promoters for GNPDA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187947 255 1201 MLX ARNT ARID4B SIN3A DMAP1 ZNF766 GLIS2 GATA2 ELK1 ZNF143

Genomic Location for GNPDA1 Gene

Chromosome:
5
Start:
141,991,749 bp from pter
End:
142,013,055 bp from pter
Size:
21,307 bases
Orientation:
Minus strand

Genomic View for GNPDA1 Gene

Genes around GNPDA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNPDA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNPDA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNPDA1 Gene

Proteins for GNPDA1 Gene

  • Protein details for GNPDA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46926-GNPI1_HUMAN
    Recommended name:
    Glucosamine-6-phosphate isomerase 1
    Protein Accession:
    P46926
    Secondary Accessions:
    • B7Z3X4
    • D3DQE7

    Protein attributes for GNPDA1 Gene

    Size:
    289 amino acids
    Molecular mass:
    32669 Da
    Quaternary structure:
    • Homohexamer.
    SequenceCaution:
    • Sequence=BAA06544.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GNPDA1 Gene

    Alternative splice isoforms for GNPDA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GNPDA1 Gene

Selected DME Specific Peptides for GNPDA1 Gene

P46926:
  • NFFKHIDI
  • SRTRVKTL
  • ALTVGVGT
  • TFNMDEYV
  • GHIAFNEP
  • HPESYHSFM
  • TGSTPLG
  • VNHMWTVSA
  • KTLAMDTILANA
  • ELKVKTVKYF
  • FNEPGSS
  • VKTVKYFKGLM
  • VHNKLVDPL
  • SFMWNNFF
  • HILDGNA
  • DEDATLEL
  • LFVGGIGPDGH

Post-translational modifications for GNPDA1 Gene

  • Ubiquitination at isoforms=2256 and isoforms=2264
  • Modification sites at PhosphoSitePlus

Domains & Families for GNPDA1 Gene

Gene Families for GNPDA1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GNPDA1 Gene

Graphical View of Domain Structure for InterPro Entry

P46926

UniProtKB/Swiss-Prot:

GNPI1_HUMAN :
  • Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
Family:
  • Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
genes like me logo Genes that share domains with GNPDA1: view

Function for GNPDA1 Gene

Molecular function for GNPDA1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Alpha-D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3).
UniProtKB/Swiss-Prot Function:
Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).

Enzyme Numbers (IUBMB) for GNPDA1 Gene

Gene Ontology (GO) - Molecular Function for GNPDA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004342 glucosamine-6-phosphate deaminase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with GNPDA1: view
genes like me logo Genes that share phenotypes with GNPDA1: view

Animal Models for GNPDA1 Gene

MGI Knock Outs for GNPDA1:

Animal Model Products

  • Taconic Biosciences Mouse Models for GNPDA1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GNPDA1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GNPDA1 Gene

Localization for GNPDA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNPDA1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNPDA1 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GNPDA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS,IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GNPDA1: view

Pathways & Interactions for GNPDA1 Gene

genes like me logo Genes that share pathways with GNPDA1: view

Gene Ontology (GO) - Biological Process for GNPDA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006043 glucosamine catabolic process TAS --
GO:0006044 N-acetylglucosamine metabolic process IEA --
GO:0006091 generation of precursor metabolites and energy IMP 9438414
GO:0007338 single fertilization TAS 9714720
genes like me logo Genes that share ontologies with GNPDA1: view

No data available for SIGNOR curated interactions for GNPDA1 Gene

Drugs & Compounds for GNPDA1 Gene

(10) Drugs for GNPDA1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ammonia Approved Pharma 0
Water Approved Pharma 0
glucosamine 6-phosphate Experimental Pharma 0
2-Deoxy-2-Amino Glucitol-6-Phosphate Experimental Pharma Target 0
Beta-D-Glucose Experimental Pharma Target 0

(4) Additional Compounds for GNPDA1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fructose 6-phosphate
  • D-Fructose 6-phosphate
  • D-Fructose 6-phosphorate
  • D-Fructose 6-phosphoric acid
  • D-Fructose-6-P
  • D-Fructose-6-phosphate
643-13-0
N-Acetyl-D-Glucosamine 6-Phosphate
  • N-Acetyl-D-Glucosamine 6-Phosphate
  • N-Acetyl-D-glucosamine-6-p
  • N-Acetyl-D-glucosamine-6-phosphate
  • N-Acetyl-glucosamine-6-p
  • N-Acetyl-glucosamine-6-phosphate
102029-88-9
genes like me logo Genes that share compounds with GNPDA1: view

Transcripts for GNPDA1 Gene

Unigene Clusters for GNPDA1 Gene

Glucosamine-6-phosphate deaminase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GNPDA1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GNPDA1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c
SP1: -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - -
SP6: -
SP7: - -
SP8: - - -
SP9: - - - - - - -
SP10: - - - -
SP11: - - -
SP12: - - -
SP13: - - - - -
SP14: - -

Relevant External Links for GNPDA1 Gene

GeneLoc Exon Structure for
GNPDA1
ECgene alternative splicing isoforms for
GNPDA1

Expression for GNPDA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GNPDA1 Gene

Protein differential expression in normal tissues from HIPED for GNPDA1 Gene

This gene is overexpressed in Spleen (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GNPDA1 Gene



Protein tissue co-expression partners for GNPDA1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GNPDA1 Gene:

GNPDA1

SOURCE GeneReport for Unigene cluster for GNPDA1 Gene:

Hs.633853

Evidence on tissue expression from TISSUES for GNPDA1 Gene

  • Nervous system(4.8)
  • Skin(4.5)
  • Bone marrow(4.1)
  • Kidney(2.3)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with GNPDA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNPDA1 Gene

Orthologs for GNPDA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GNPDA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNPDA1 33 34
  • 99.77 (n)
cow
(Bos Taurus)
Mammalia GNPDA1 33 34
  • 94.12 (n)
dog
(Canis familiaris)
Mammalia GNPDA1 33 34
  • 92.27 (n)
rat
(Rattus norvegicus)
Mammalia Gnpda1 33
  • 90.43 (n)
mouse
(Mus musculus)
Mammalia Gnpda1 16 34 33
  • 90.31 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 90 (a)
OneToMany
-- 34
  • 89 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 81 (a)
OneToMany
-- 34
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves GNPDA1 34
  • 91 (a)
OneToMany
-- 34
  • 85 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia GNPDA1 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gnpda1 33
  • 77.85 (n)
zebrafish
(Danio rerio)
Actinopterygii gnpda1 33 34
  • 78.78 (n)
Dr.18431 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10253 33
fruit fly
(Drosophila melanogaster)
Insecta Oscillin 34
  • 73 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T03F6.3 34
  • 69 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10232 34
  • 79 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.654 33
Species where no ortholog for GNPDA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNPDA1 Gene

ENSEMBL:
Gene Tree for GNPDA1 (if available)
TreeFam:
Gene Tree for GNPDA1 (if available)

Paralogs for GNPDA1 Gene

Paralogs for GNPDA1 Gene

(1) SIMAP similar genes for GNPDA1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with GNPDA1: view

Variants for GNPDA1 Gene

Sequence variations from dbSNP and Humsavar for GNPDA1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000169409 -- 142,008,396(+) TTCCC(C/T)GAGGA intron-variant
rs1000363633 -- 142,001,413(+) CTCTT(C/T)GGCCC utr-variant-3-prime
rs1000557263 -- 142,013,757(+) GTGAG(A/G)TAGGT upstream-variant-2KB
rs1000809671 -- 142,007,092(+) GAGAA(G/T)TTGTT intron-variant
rs1000845197 -- 142,003,017(+) TGAAA(C/G)CTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNPDA1 Gene

Variant ID Type Subtype PubMed ID
nsv1154058 CNV deletion 26484159
nsv5036 CNV insertion 18451855
nsv511116 OTHER complex 20534489

Variation tolerance for GNPDA1 Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNPDA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNPDA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNPDA1 Gene

Disorders for GNPDA1 Gene

Relevant External Links for GNPDA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNPDA1

No disorders were found for GNPDA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNPDA1 Gene

Publications for GNPDA1 Gene

  1. The human glucosamine-6-phosphate deaminase gene: cDNA cloning and expression, genomic organization and chromosomal localization. (PMID: 9714720) Shevchenko V … Lai FA (Gene 1998) 2 3 4 22 60
  2. Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study. (PMID: 12965206) Arreola R … Horjales E (FEBS letters 2003) 3 4 22 60
  3. Molecularly cloned mammalian glucosamine-6-phosphate deaminase localizes to transporting epithelium and lacks oscillin activity. (PMID: 9438414) Wolosker H … Snyder SH (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998) 2 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 60

Products for GNPDA1 Gene

Sources for GNPDA1 Gene

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