Aliases for GNMT Gene
External Ids for GNMT Gene
Previous GeneCards Identifiers for GNMT Gene
The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. This protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia). Alternative splicing results in multiple transcript variants. Naturally occurring readthrough transcription occurs between the upstream CNPY3 (canopy FGF signaling regulator 3) gene and this gene and is represented with GeneID:107080644. [provided by RefSeq, Jan 2016]
GeneCards Summary for GNMT Gene
GNMT (Glycine N-Methyltransferase) is a Protein Coding gene. Diseases associated with GNMT include Glycine N-Methyltransferase Deficiency and Hypermethioninemia With Deficiency Of S-Adenosylhomocysteine Hydrolase. Among its related pathways are Glycine, serine and threonine metabolism and Metabolism. GO annotations related to this gene include methyltransferase activity and folic acid binding.
UniProtKB/Swiss-Prot for GNMT Gene
Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.