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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNMT Gene

protein-coding   GIFtS: 61
GCID: GC06P042928

glycine N-methyltransferase

 Explore 17 diseases affiliated with
GNMT via our new
 Human Malady Compendium 
Biological research products
for GNMT
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Glycine N-Methyltransferase1 2
EC 2.1.1.203 8

External Ids:    HGNC: 44151   Entrez Gene: 272322   Ensembl: ENSG000001247137   OMIM: 6066285   UniProtKB: Q147493   

Export aliases for GNMT gene to outside databases

Previous GC identifers: GC06P042930 GC06P042975 GC06P043037 GC06P042645


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GNMT:
The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with
glycine) to S-adenosyl-L-homocysteine and sarcosine. The encoded protein is found in the cytoplasm and acts as a
homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia). (provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: GNMT_HUMAN, Q14749
Function: Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine
(sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the
regulation of tissue concentration of AdoMet and of metabolism of methionine

Gene Wiki entry for GNMT


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNMT gene promoter:
         E2F-4   E2F-3a   E2F-5   Pax-5   Nkx2-5   E2F-2   LCR-F1   C/EBPalpha   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNMT promoter sequence
   Search SABiosciences Chromatin IP Primers for GNMT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNMT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p12

GNMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNMT gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P042928:  view genomic region     (about GC identifiers)

Start:
42,928,496 bp from pter      End:
42,931,618 bp from pter
Size:
3,123 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GNMT_HUMAN, Q14749 (See protein sequence)
Recommended Name: Glycine N-methyltransferase  
Size: 295 amino acids; 32742 Da
Subunit: Homotetramer
Subcellular location: Cytoplasm
2 PDB 3D structures from and Proteopedia for GNMT:
1R74 (3D)        2AZT (3D)    
Secondary accessions: Q5T8W2 Q9NNZ1 Q9NS24

Explore the universe of human proteins at neXtProt for GNMT: NX_Q14749

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14749

  • 4/7 DME Specific Peptides for GNMT (Q14749) (see all 7)
     WVIEEANW  PCYFIHVL  WLLGLLRQHGC  GGLLVIDHRNYD 

    GNMT Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_061833.1  
    ENSEMBL proteins: 
     ENSP00000361894  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: GNMT
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    Novus Biologicals GNMT Proteins
    Novus Biologicals GNMT Lysates
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    ProSpec Recombinant Protein for GNMT
    Uscn Proteins for GNMT

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol ----


    GNMT for ontologies           About GeneDecksing



    GNMT Antibody Products: 
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    Uscn ELISAs and CLIAs for GNMT


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GNMT for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR014369 Gly/Sar_N_MeTrfase

    Graphical View of Domain Structure for InterPro Entry Q14749

    ProtoNet protein and cluster: Q14749

    UniProtKB/Swiss-Prot: GNMT_HUMAN, Q14749
    Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: GNMT_HUMAN, Q14749
    Function: Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine
    (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the
    regulation of tissue concentration of AdoMet and of metabolism of methionine
    Catalytic activity: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine

    Enzyme Number (IUBMB): EC 2.1.1.201 2

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    Inhib. RNA
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005542folic acid binding IEA--
    GO:0008757S-adenosylmethionine-dependent methyltransferase activity ----
    GO:0016594glycine binding IDA15340920
    GO:0017174glycine N-methyltransferase activity IDA15340920


    GNMT for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for GNMT: Gnmttm1Ymac Gnmttm1Cwa
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gnmt):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     tumorigenesis 

    GNMT for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glycine, serine and threonine metabolism
    Glycine, serine and threonine metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for GNMT):
        Glycine, serine and threonine metabolism


    GNMT for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GNMT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/27 Interacting proteins for GNMT (Q147491, 2, 3 ENSP000003618944) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARRB1P494071, 2, 3, ENSP000003771414EBI-744239,EBI-2561130 MINT-66963 I2D: score=5 STRING: ENSP00000377141
    PLEKHF2Q9H8W42, 3, ENSP000003223734MINT-66656 I2D: score=5 STRING: ENSP00000322373
    ARR3P365752, 3, ENSP000003115384MINT-66473 I2D: score=5 STRING: ENSP00000311538
    NIF3L1Q9GZT82, 3, ENSP000003863944MINT-66781 I2D: score=5 STRING: ENSP00000386394
    NUDT18Q6ZVK82, 3, ENSP000003078524MINT-66994 I2D: score=5 STRING: ENSP00000307852
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005977glycogen metabolic process IEA--
    GO:0006111regulation of gluconeogenesis IEA--
    GO:0006464cellular protein modification process NAS10843803
    GO:0006555methionine metabolic process IEA--
    GO:0006730one-carbon metabolic process IEA--


    GNMT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GNMT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GNMT

    5 HMDB Compounds for GNMT    About this table
    CompoundSynonyms CAS #PubMed Ids
    Folic acidAcifolic (see all 37)59-30-3--
    Glycine2-Aminoacetate (see all 15)56-40-6--
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--
    Sarcosine(Methylamino)acetate (see all 15)107-97-1--

    4 DrugBank Compounds for GNMT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    S-AdenosylmethionineAcylcarnitine (see all 6)29908-03-0targetcofactor11435507 12742526 12221207 11810299 12697024
    Glycine2-Aminoacetic acid (see all 4)56-40-6target--16851960 17154529 17158459
    Citric Acid-- 77-92-9target--17139284 17016423
    S-Adenosyl-L-Homocysteine-- 979-92-0target--10592235

    9 Novoseek chemical compound relationships for GNMT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sarcosine 88.5 12 12859184 (1), 9655336 (1), 10756111 (1), 9597750 (1) (see all 6)
    s-adenosylmethionine 87.5 50 10756111 (5), 9597750 (4), 18804700 (3), 9655336 (2) (see all 19)
    s-adenosylhomocysteine 87 25 10756111 (5), 12859184 (2), 9655336 (2), 11810299 (1) (see all 12)
    cystathionine 76.2 2 11131452 (1), 15963701 (1)
    methionine 71.9 18 11810299 (2), 15122759 (2), 15963701 (2), 15852300 (1) (see all 10)
    homocysteine 64.7 3 16317120 (2), 16047261 (1)
    folate 56.8 20 16317120 (2), 18501206 (2), 18804700 (2), 11810299 (1) (see all 8)
    benzo(a)pyrene 40.2 18 15150120 (5), 16545412 (4)
    hydrogen 14.7 1 19733262 (1)

    Search CenterWatch for drugs/clinical trials and news about GNMT 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GNMT gene: 
    NM_018960.4  

    Unigene Cluster for GNMT:

    Glycine N-methyltransferase
    Hs.144914  [show with all ESTs]
    Unigene Representative Sequence: AK092088
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000372808(uc003otd.3)

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    Additional cDNA sequence: 

    AF101477.1 AK092088.1 BC032627.1 

    7 DOTS entries:

    DT.70105475  DT.121394107  DT.92420728  DT.75150474  DT.95080736  DT.121394175  DT.75116165 

    24/366 AceView cDNA sequences (see all 366):

    CF144914 CR620849 BQ063472 BG762655 CN483427 BQ883867 BM924653 BF093158 
    R46414 BQ064406 CR606170 BQ067430 AI469829 BU185418 CD672422 CD672419 
    BU838086 AI870894 BQ680146 CB306963 BI253605 CR620344 BM920245 AF101477 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for GNMT    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for GNMT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNMT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGACCCTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See GNMT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNMT

    SOURCE GeneReport for Unigene cluster: Hs.144914

    UniProtKB/Swiss-Prot: GNMT_HUMAN, Q14749
    Tissue specificity: Abundant in liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including GNMT: 
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              Drug Metabolism: Phase II Enzymes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for GNMT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GNMT gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gnmt1 , 5 glycine N-methyltransferase1, 5 88.05(n)1
    92.15(a)1
      17 (22.90 cM)5
    147111  NM_010321.11  NP_034451.11 
     467256645 
    chicken
    (Gallus gallus)
    Aves GNMT1 glycine N-methyltransferase 78.04(n)
    78.85(a)
      769542  XM_001232828.2  XP_001232829.2 
    lizard
    (Anolis carolinensis)
    Reptilia GNMT6
    --
    80(a)
    1 ↔ 1
    2(144878056-144890419)
    zebrafish
    (Danio rerio)
    Actinopterygii wufb02g112 Danio rerio cDNA clone MGC77856 IMAGE7002345, complete more 74.39(n)    BC062527.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG61881 , 3 glycine N-methyltransferase3
    CG61881
    57(a)3
    63.46(n)1
    59.07(a)1
      87C53
    415611  NM_141966.31  NP_650223.11 


    ENSEMBL Gene Tree for GNMT (if available)
    TreeFam Gene Tree for GNMT (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/100 NCBI SNPs in GNMT are shown (see all 100    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219078891,2
    C,Fpathogenic42930887(+) TTGATC/AATCGC 2 /N /H mis12Minor allele frequency- A:0.00NA EU 5817
    rs1834481851,2
    --42926544(+) GCAGTG/TGCGCA 1 -- us2k10--------
    rs1865826321,2
    --42926545(+) CAGTGC/GCGCAA 1 -- us2k10--------
    rs1446579841,2
    --42926633(+) GGCACG/TTGCCA 1 -- us2k10--------
    rs1112642571,2
    --42926801(+) AGCACT/CGGGGC 1 -- us2k12Minor allele frequency- C:0.10CSA WA 119
    rs1125381871,2
    C,F,--42926834(+) TCACCC/GGTTAA 1 -- us2k16Minor allele frequency- G:0.16NA WA CSA EA 246
    rs1898509511,2
    --42926849(+) GCCCCC/TTGCTT 1 -- us2k10--------
    rs1824227641,2
    --42927022(+) TGAGCA/GCCTGT 1 -- us2k10--------
    rs1883599181,2
    --42927081(+) GAGGCA/GGAGAT 1 -- us2k10--------
    rs1928149131,2
    --42927110(+) CACCAC/TGGCAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GNMT (42928496 - 42931618 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for GNMT: --
    Human Gene Mutation Database (HGMD): GNMT

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GNMT
    DNA2.0 Custom Variant and Variant Library Synthesis for GNMT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GNMT for disorders           About GeneDecksing

    OMIM gene information: 606628   
    OMIM disorders: 606664  
    UniProtKB/Swiss-Prot: GNMT_HUMAN, Q14749
  • Defects in GNMT are the cause of glycine N-methyltransferase deficiency (GNMT deficiency) [MIM:606664]; also
  • known as hypermethioninemia. The only clinical abnormalities in patients with this deficiency are mild hepatomegaly
    and chronic elevation of serum transaminases

    17 diseases for GNMT:    About MalaCards
    glycine n-methyltransferase deficiency    hypermethioninemia    homocysteine    glycogen storage disease
    spina bifida    liver cirrhosis    liver disease    hyperhomocysteinemia
    hepatocellular carcinoma    liver cancer    cholangiocarcinoma    prostate cancer
    carcinoma    prostatitis    pancreatitis    hepatitis
    alcoholism

    2 diseases from the University of Copenhagen DISEASES database for GNMT:
    Hypermethioninemia     Hepatocellular carcinoma

    5 Novoseek disease relationships for GNMT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gnmt deficiency 97.7 20 14739680 (3), 11596649 (2), 17937387 (2), 12566990 (1) (see all 5)
    hepatocellular carcinoma 55.7 12 12566309 (1), 18318442 (1), 18624901 (1), 10843803 (1) (see all 7)
    hepatomegaly 50.5 2 12566990 (1)
    liver diseases 35.1 1 18318442 (1)
    tumors 0 14 12566309 (4), 17332283 (2), 18624901 (1), 19035462 (1) (see all 6)

    Genetic Association Database (GAD): GNMT
    Human Genome Epidemiology (HuGE) Navigator: GNMT (7 documents)

    Export disorders for GNMT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNMT gene, integrated from 9 sources (see all 80):
    (articles sorted by number of sources associating them with GNMT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism. (PubMed id 11810299)1, 2, 7, 9 Luka Z.... Wagner C. (2002)
    2. Characterization of glycine-N-methyltransferase-gene expression in human hepatocellular carcinoma. (PubMed id 9495250)1, 2, 3, 9 Chen Y.M....Chen P.H. (1998)
    3. Genomic structure, expression, and chromosomal localization of the human glycine N-methyltransferase gene. (PubMed id 10843803)1, 2, 3, 9 Chen Y.-M.A....Yang-Feng T.L. (2000)
    4. Glycine N-methyltransferase deficiency: a new patient with a novel mutation. (PubMed id 14739680)1, 2, 9 Augoustides-Savvopoulou P.... Mudd S.H. (2003)
    5. The glycine N-methyltransferase (GNMT) 1289 C->T variant influences plasma total homocysteine concentrations in young women after restricting folate intake. (PubMed id 16317120)1, 4, 9 Beagle B....Caudill M.A. (2005)
    6. Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes. (PubMed id 15340920)1, 2, 9 Pakhomova S....Newcomer M.E. (2004)
    7. Effect of naturally occurring mutations in human glycine N- methyltransferase on activity and conformation. (PubMed id 14651980)1, 2, 9 Luka Z. and Wagner C. (2003)
    8. Destabilization of human glycine N-methyltransferase by H176N mutation. (PubMed id 17660255)1, 2, 9 Luka Z....Wagner C. (2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes. (PubMed id 12697024)1, 7 Moller M.T....Seglen P.O. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27232 HGNC: 4415 AceView: TNRC5andGNMT Ensembl:ENSG00000124713 euGenes: HUgn27232
    ECgene: GNMT Kegg: 27232 H-InvDB: GNMT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNMT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GNMT gene:
    Search GeneIP for patents involving GNMT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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