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GNMT Gene

protein-coding   GIFtS: 63
GCID: GC06P042928

Glycine N-Methyltransferase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glycine N-Methyltransferase1 2
EC 2.1.1.203 8
HEL-S-182mP2
Epididymis Secretory Sperm Binding Protein Li 182mP2

External Ids:    HGNC: 44151   Entrez Gene: 272322   Ensembl: ENSG000001247137   OMIM: 6066285   UniProtKB: Q147493   

Export aliases for GNMT gene to outside databases

Previous GC identifers: GC06P042930 GC06P042975 GC06P043037 GC06P042645


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GNMT Gene:
The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with
glycine) to S-adenosyl-L-homocysteine and sarcosine. The encoded protein is found in the cytoplasm and acts as a
homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia). (provided by RefSeq, Oct
2008)

GeneCards Summary for GNMT Gene:
GNMT (glycine N-methyltransferase) is a protein-coding gene. Diseases associated with GNMT include glycine n-methyltransferase deficiency, and hypermethioninemia. GO annotations related to this gene include glycine N-methyltransferase activity and folic acid binding.

UniProtKB/Swiss-Prot: GNMT_HUMAN, Q14749
Function: Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine
(sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the
regulation of tissue concentration of AdoMet and of metabolism of methionine

Gene Wiki entry for GNMT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNMT gene promoter:
         E2F-4   E2F-3a   E2F-5   Pax-5   Nkx2-5   E2F-2   LCR-F1   C/EBPalpha   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNMT promoter sequence
   Search Chromatin IP Primers for GNMT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNMT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p12

GNMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNMT gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P042928:  view genomic region     (about GC identifiers)

Start:
42,928,496 bp from pter      End:
42,931,618 bp from pter
Size:
3,123 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GNMT_HUMAN, Q14749 (See protein sequence)
Recommended Name: Glycine N-methyltransferase  
Size: 295 amino acids; 32742 Da
Subunit: Homotetramer
2 PDB 3D structures from and Proteopedia for GNMT:
1R74 (3D)        2AZT (3D)    
Secondary accessions: Q5T8W2 Q9NNZ1 Q9NS24

Explore the universe of human proteins at neXtProt for GNMT: NX_Q14749

Explore proteomics data for GNMT at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GNMT (Q14749) (see all 7)
     WVIEEANW  PCYFIHVL  WLLGLLRQHGC  GGLLVIDHRNYD 


    See GNMT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061833.1  
    ENSEMBL proteins: 
     ENSP00000361894  

    GNMT Human Recombinant Protein Products:

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    GNMT Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for GNMT
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    Cloud-Clone Corp. CLIAs for GNMT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR014369 Gly/Sar_N_MeTrfase

    Graphical View of Domain Structure for InterPro Entry Q14749

    ProtoNet protein and cluster: Q14749

    UniProtKB/Swiss-Prot: GNMT_HUMAN, Q14749
    Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase
    family


    GNMT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GNMT_HUMAN, Q14749
    Function: Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine
    (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the
    regulation of tissue concentration of AdoMet and of metabolism of methionine
    Catalytic activity: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine

         Enzyme Number (IUBMB): EC 2.1.1.201 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0005542folic acid binding IEA--
    GO:0008168methyltransferase activity ----
    GO:0016594glycine binding IDA15340920
    GO:0017174glycine N-methyltransferase activity IDA15340920
         
    GNMT for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gnmt):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     tumorigenesis 

    GNMT for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GNMT: Gnmttm1Ymac Gnmttm1Cwa

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GNMT
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GNMT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GNMT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GNMT

    miRNA
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    miRTarBase miRNAs that target GNMT:
    hsa-mir-335-5p (MIRT016781)

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    Search for qRT-PCR Assays for microRNAs that regulate GNMT
    SwitchGear 3'UTR luciferase reporter plasmidGNMT 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GNMT

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: GNMT (NM_018960)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNMT

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNMT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GNMT_HUMAN, Q14749: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--

    GNMT for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GNMT About    
    See pathways by source

    SuperPathContained pathways About
    1Glycine, serine and threonine metabolism
    Glycine, serine and threonine metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for GNMT):
        Glycine, serine and threonine metabolism


    GNMT for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GNMT: 
              Amino Acid Metabolism II in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GNMT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for GNMT (Q147491, 2, 3 ENSP000003618944) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARRB1P494071, 2, 3, ENSP000003771414EBI-744239,EBI-743313 MINT-66963 I2D: score=5 STRING: ENSP00000377141
    PLEKHF2Q9H8W42, 3, ENSP000003223734MINT-66656 I2D: score=5 STRING: ENSP00000322373
    ARR3P365752, 3, ENSP000003115384MINT-66473 I2D: score=5 STRING: ENSP00000311538
    NIF3L1Q9GZT82, 3, ENSP000003863944MINT-66781 I2D: score=5 STRING: ENSP00000386394
    NUDT18Q6ZVK82, 3, ENSP000003078524MINT-66994 I2D: score=5 STRING: ENSP00000307852
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005977glycogen metabolic process IEA--
    GO:0006111regulation of gluconeogenesis IEA--
    GO:0006464cellular protein modification process NAS10843803
    GO:0006555methionine metabolic process IEA--
    GO:0006730one-carbon metabolic process IEA--

    GNMT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GNMT

    5 HMDB Compounds for GNMT    About this table
    CompoundSynonyms CAS #PubMed Ids
    Folic acidAcifolic (see all 37)59-30-3--
    Glycine2-Aminoacetate (see all 15)56-40-6--
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--
    Sarcosine(Methylamino)acetate (see all 15)107-97-1--

    4 DrugBank Compounds for GNMT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    S-AdenosylmethionineAcylcarnitine (see all 6)29908-03-0targetcofactor11435507 12742526 12221207 11810299 12697024
    Glycine2-Aminoacetic acid (see all 4)56-40-6target--16851960 17154529 17158459
    Citric Acid-- 77-92-9target--17139284 17016423
    S-Adenosyl-L-Homocysteine-- 979-92-0target--10592235

    9 Novoseek inferred chemical compound relationships for GNMT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sarcosine 88.5 12 12859184 (1), 9655336 (1), 10756111 (1), 9597750 (1) (see all 6)
    s-adenosylmethionine 87.5 50 10756111 (5), 9597750 (4), 18804700 (3), 9655336 (2) (see all 19)
    s-adenosylhomocysteine 87 25 10756111 (5), 12859184 (2), 9655336 (2), 11810299 (1) (see all 12)
    cystathionine 76.2 2 11131452 (1), 15963701 (1)
    methionine 71.9 18 11810299 (2), 15122759 (2), 15963701 (2), 15852300 (1) (see all 10)
    homocysteine 64.7 3 16317120 (2), 16047261 (1)
    folate 56.8 20 16317120 (2), 18501206 (2), 18804700 (2), 11810299 (1) (see all 8)
    benzo(a)pyrene 40.2 18 15150120 (5), 16545412 (4)
    hydrogen 14.7 1 19733262 (1)



    GNMT for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GNMT gene: 
    NM_018960.4  

    Unigene Cluster for GNMT:

    Glycine N-methyltransferase
    Hs.144914  [show with all ESTs]
    Unigene Representative Sequence: AK092088
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000372808(uc003otd.3)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat GNMT

    Additional mRNA sequence: 

    AF101477.1 AK092088.1 BC032627.1 

    6 DOTS entries:

    DT.70105475  DT.121394107  DT.92420728  DT.75150474  DT.95080736  DT.121394175 

    Selected AceView cDNA sequences (see all 366):

    R46414 AI202110 BM924653 BQ928301 BQ064406 AI272753 CR606170 BE891650 
    CA488794 BU553173 CR620849 AI870894 BU188776 BE741659 BU145768 CF144914 
    BM920245 CR593913 CR605378 CK429647 AI285290 AI878843 AW160553 BQ067430 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for GNMT    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for GNMT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GNMT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGACCCTGG
    GNMT Expression
    About this image

    GNMT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNMT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.144914

    UniProtKB/Swiss-Prot: GNMT_HUMAN, Q14749
    Tissue specificity: Abundant in liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GNMT: 
              Amino Acid Metabolism II in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Primer
    Products:
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    QuantiFast Probe-based Assays in human, mouse, rat GNMT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNMT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GNMT gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gnmt1 , 5 glycine N-methyltransferase1, 5 88.05(n)1
    92.15(a)1
      17 (22.90 cM)5
    147111  NM_010321.11  NP_034451.11 
     467256645 
    chicken
    (Gallus gallus)
    Aves GNMT6
    glycine N-methyltransferase
    78(a)
    1 ↔ 1
    3(15379651-15381158)
    lizard
    (Anolis carolinensis)
    Reptilia GNMT6
    glycine N-methyltransferase
    80(a)
    1 ↔ 1
    2(144878019-144890846)
    zebrafish
    (Danio rerio)
    Actinopterygii wufb02g112 Danio rerio cDNA clone MGC77856 IMAGE7002345, complete more 74.39(n)    BC062527.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG61881 , 3 glycine N-methyltransferase3
    CG61881
    57(a)3
    63.46(n)1
    59.07(a)1
      87C53
    415611  NM_141966.41  NP_650223.11 


    ENSEMBL Gene Tree for GNMT (if available)
    TreeFam Gene Tree for GNMT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GNMT (see all 129)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0198404
    Glycine N-methyltransferase deficiency (GNMT deficiency)4--see VAR_0198402 N S mis40--------
    VAR_0127674
    Glycine N-methyltransferase deficiency (GNMT deficiency)4--see VAR_0127672 H N mis40--------
    VAR_0127664
    Glycine N-methyltransferase deficiency (GNMT deficiency)4--see VAR_0127662 L P mis40--------
    rs1219078891,2
    C,Fpathogenic142841802(+) TTGATC/AATCGC 2 /N /H mis12Minor allele frequency- A:0.00NA EU 5817
    rs1834481851,2
    --42837459(+) GCAGTG/TGCGCA 1 -- us2k10--------
    rs1865826321,2
    --42837460(+) CAGTGC/GCGCAA 1 -- us2k10--------
    rs1446579841,2
    --42837548(+) GGCACG/TTGCCA 1 -- us2k10--------
    rs1112642571,2
    C,F--42837716(+) AGCACT/CGGGGC 1 -- us2k12Minor allele frequency- C:0.10CSA WA 119
    rs1125381871,2
    C,F--42837749(+) TCACCC/GGTTAA 1 -- us2k16Minor allele frequency- G:0.16NA WA CSA EA 246
    rs1898509511,2
    --42837764(+) GCCCCC/TTGCTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GNMT (42928496 - 42931618 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GNMT:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv462927CNV Loss19166990
    nsv830651CNV Loss17160897

    Human Gene Mutation Database (HGMD): GNMT
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606628   
    OMIM disorders: 606664  
    UniProtKB/Swiss-Prot: GNMT_HUMAN, Q14749
  • Glycine N-methyltransferase deficiency (GNMT deficiency) [MIM:606664]: The only clinical abnormalities in
    patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 17 diseases for GNMT:    
    About MalaCards
    glycine n-methyltransferase deficiency    hypermethioninemia    spina bifida    hyperhomocysteinemia
    glycogen storage disease    hepatocellular carcinoma    liver disease    liver cirrhosis
    cholangiocarcinoma    atherosclerosis    prostate cancer    malaria
    prostatitis    multiple myeloma    myeloma    hepatitis
    pancreatitis

    2 diseases from the University of Copenhagen DISEASES database for GNMT:
    Hepatocellular carcinoma     Hyperhomocysteinemia

    GNMT for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for GNMT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gnmt deficiency 97.7 20 14739680 (3), 11596649 (2), 17937387 (2), 12566990 (1) (see all 5)
    hepatocellular carcinoma 55.7 12 12566309 (1), 18318442 (1), 18624901 (1), 10843803 (1) (see all 7)
    hepatomegaly 50.5 2 12566990 (1)
    liver diseases 35.1 1 18318442 (1)
    tumors 0 14 12566309 (4), 17332283 (2), 18624901 (1), 19035462 (1) (see all 6)

    Genetic Association Database (GAD): GNMT
    Human Genome Epidemiology (HuGE) Navigator: GNMT (7 documents)

    Export disorders for GNMT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GNMT gene, integrated from 10 sources (see all 83):
    (articles sorted by number of sources associating them with GNMT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism. (PubMed id 11810299)1, 2, 7, 9 Luka Z.... Wagner C. (Hum. Genet. 2002)
    2. Characterization of glycine-N-methyltransferase-gene expression in human hepatocellular carcinoma. (PubMed id 9495250)1, 2, 3, 9 Chen Y.-M.A....Chen P.H. (Int. J. Cancer 1998)
    3. Genomic structure, expression, and chromosomal localization of the human glycine N-methyltransferase gene. (PubMed id 10843803)1, 2, 3, 9 Chen Y.-M.A....Yang-Feng T.L. (Genomics 2000)
    4. Haplotypes, loss of heterozygosity, and expression levels of glycine N-methyltransferase in prostate cancer. (PubMed id 17332283)1, 4, 9 Huang Y.C....Chen Y.M. (Clin. Cancer Res. 2007)
    5. Glycine N-methyltransferase deficiency: a new patient with a novel mutation. (PubMed id 14739680)1, 2, 9 Augoustides-Savvopoulou P.... Mudd S.H. (J. Inherit. Metab. Dis. 2003)
    6. The glycine N-methyltransferase (GNMT) 1289 C-&gt;T variant influences plasma total homocysteine concentrations in young women after restricting folate intake. (PubMed id 16317120)1, 4, 9 Beagle B....Caudill M.A. (J. Nutr. 2005)
    7. Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes. (PubMed id 15340920)1, 2, 9 Pakhomova S.... Newcomer M.E. (Proteins 2004)
    8. Effect of naturally occurring mutations in human glycine N- methyltransferase on activity and conformation. (PubMed id 14651980)1, 2, 9 Luka Z. and Wagner C. (Biochem. Biophys. Res. Commun. 2003)
    9. Destabilization of human glycine N-methyltransferase by H176N mutation. (PubMed id 17660255)1, 2, 9 Luka Z.... Wagner C. (Protein Sci. 2007)
    10. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27232 HGNC: 4415 AceView: TNRC5andGNMT Ensembl:ENSG00000124713 euGenes: HUgn27232
    ECgene: GNMT Kegg: 27232 H-InvDB: GNMT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GNMT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GNMT gene:
    Search GeneIP for patents involving GNMT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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