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Aliases for GNLY Gene

Aliases for GNLY Gene

  • Granulysin 2 3 5
  • T-Lymphocyte Activation Gene 519 2 3
  • T-Cell Activation Protein 519 3 4
  • Lymphokine LAG-2 3 4
  • TLA519 3 4
  • LAG2 3 4
  • NKG5 3 4
  • Lymphocyte-Activation Gene 2 3
  • Protein NKG5 4
  • D2S69E 3
  • LAG-2 3

External Ids for GNLY Gene

Previous HGNC Symbols for GNLY Gene

  • LAG2

Previous GeneCards Identifiers for GNLY Gene

  • GC02P085816
  • GC02P086215
  • GC02P085895
  • GC02P085834
  • GC02P085912

Summaries for GNLY Gene

Entrez Gene Summary for GNLY Gene

  • The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for GNLY Gene

GNLY (Granulysin) is a Protein Coding gene. Diseases associated with GNLY include Tuberculosis and Erythematosquamous Dermatosis.

UniProtKB/Swiss-Prot for GNLY Gene

  • Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.

Gene Wiki entry for GNLY Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNLY Gene

Genomics for GNLY Gene

Regulatory Elements for GNLY Gene

Enhancers for GNLY Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GNLY on UCSC Golden Path with GeneCards custom track

Genomic Location for GNLY Gene

85,685,175 bp from pter
85,698,854 bp from pter
13,680 bases
Plus strand

Genomic View for GNLY Gene

Genes around GNLY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNLY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNLY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNLY Gene

Proteins for GNLY Gene

  • Protein details for GNLY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • P09325
    • Q6GU08

    Protein attributes for GNLY Gene

    145 amino acids
    Molecular mass:
    16374 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GNLY Gene

    Alternative splice isoforms for GNLY Gene


neXtProt entry for GNLY Gene

Proteomics data for GNLY Gene at MOPED

Post-translational modifications for GNLY Gene

  • A 9 kDa form is produced by proteolytic processing of a 15 kDa protein.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNLY Gene

Antibody Products

  • Abcam antibodies for GNLY

No data available for DME Specific Peptides for GNLY Gene

Domains & Families for GNLY Gene

Protein Domains for GNLY Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 saposin B-type domain.
  • Contains 1 saposin B-type domain.
genes like me logo Genes that share domains with GNLY: view

No data available for Gene Families for GNLY Gene

Function for GNLY Gene

Molecular function for GNLY Gene

GENATLAS Biochemistry:
Granulysin,expressed by cytolytic T-lymphocytes and NK cells,located in cytotoxic granules,involved in immunity against intracellular infection against M tuberculosis and other pathogens
UniProtKB/Swiss-Prot Function:
Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.
UniProtKB/Swiss-Prot Induction:
By T-cell growth factor and IL2/interleukin-2.
genes like me logo Genes that share phenotypes with GNLY: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GNLY Gene

Localization for GNLY Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNLY Gene

Secreted. Note=Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.

Subcellular locations from

Jensen Localization Image for GNLY Gene COMPARTMENTS Subcellular localization image for GNLY gene
Compartment Confidence
extracellular 5
cytosol 2
lysosome 2
vacuole 2
mitochondrion 1
nucleus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for GNLY Gene

Pathways & Interactions for GNLY Gene

SuperPathways for GNLY Gene

No Data Available

Interacting Proteins for GNLY Gene

Gene Ontology (GO) - Biological Process for GNLY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042742 defense response to bacterium IEA --
GO:0050832 defense response to fungus IEA --
genes like me logo Genes that share ontologies with GNLY: view

No data available for Pathways by source and SIGNOR curated interactions for GNLY Gene

Drugs & Compounds for GNLY Gene

(8) Drugs for GNLY Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
3[N-Morpholino]Propane Sulfonic Acid Experimental Pharma Target 0

(9) Additional Compounds for GNLY Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GNLY: view

Transcripts for GNLY Gene

Unigene Clusters for GNLY Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNLY Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - - - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: - - -
SP5: - - - - - -
SP6: - -
SP7: - - - - - - - - -
SP8: - - - - - -
SP9: - - - -
SP12: - -

Relevant External Links for GNLY Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GNLY Gene

mRNA expression in normal human tissues for GNLY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNLY Gene

This gene is overexpressed in Whole Blood (x41.8).

Protein differential expression in normal tissues from HIPED for GNLY Gene

This gene is overexpressed in NK cells (38.9) and Peripheral blood mononuclear cells (22.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GNLY Gene

SOURCE GeneReport for Unigene cluster for GNLY Gene Hs.105806

mRNA Expression by UniProt/SwissProt for GNLY Gene

Tissue specificity: Expressed in natural killer and T-cells.
genes like me logo Genes that share expression patterns with GNLY: view

Protein tissue co-expression partners for GNLY Gene

- Elite partner

Primer Products

Orthologs for GNLY Gene

This gene was present in the common ancestor of mammals.

Orthologs for GNLY Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GNLY 35
  • 97.47 (n)
  • 93.79 (a)
  • 93 (a)
(Bos Taurus)
Mammalia -- 36
  • 38 (a)
-- 36
  • 30 (a)
-- 36
  • 38 (a)
(Canis familiaris)
Mammalia -- 36
  • 30 (a)
-- 36
  • 30 (a)
Species with no ortholog for GNLY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GNLY Gene

Gene Tree for GNLY (if available)
Gene Tree for GNLY (if available)

Paralogs for GNLY Gene

No data available for Paralogs for GNLY Gene

Variants for GNLY Gene

Sequence variations from dbSNP and Humsavar for GNLY Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs11127 - 85,697,606(+) AGTTA(C/T)CCAGG intron-variant, downstream-variant-500B, reference, missense
rs1561284 -- 85,697,172(+) GGACC(A/C)AGGTA intron-variant, utr-variant-3-prime
rs1561285 -- 85,697,261(+) CAAGG(C/G)GCTGA intron-variant, utr-variant-3-prime
rs1866138 -- 85,694,638(-) CACAC(C/T)GGACT intron-variant
rs1866139 -- 85,694,266(-) AGCAG(C/G)TCAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GNLY Gene

Variant ID Type Subtype PubMed ID
dgv4202n71 CNV Loss 21882294
nsv874465 CNV Loss 21882294
nsv2812 CNV Loss 18451855
dgv4203n71 CNV Loss 21882294
esv23053 CNV Gain 19812545

Variation tolerance for GNLY Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GNLY Gene

Disorders for GNLY Gene

MalaCards: The human disease database

(5) MalaCards diseases for GNLY Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • tuberculosis of mother, with delivery
erythematosquamous dermatosis
  • erythematosquamous dermatosis nos
hemophagocytic lymphohistiocytosis
  • haemophagocytic syndrome
hypersensitivity syndrome, carbamazepine-induced
  • toxic epidermal necrolysis
basosquamous carcinoma
  • basisquamous cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search GNLY in MalaCards View complete list of genes associated with diseases

Relevant External Links for GNLY

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GNLY: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNLY Gene

Publications for GNLY Gene

  1. A cDNA clone expressed in natural killer and T cells that likely encodes a secreted protein. (PMID: 2212946) Yabe T. … Houchins J.P. (J. Exp. Med. 1990) 2 3 4 67
  2. Intracellularly expressed granulysin induced apoptosis in hepatoma cells and role of mitochondrial apoptotic pathway. (PMID: 19111751) Yi Z. … Song W. (Cell. Immunol. 2009) 3 23
  3. The expression of granulysin in systemic anaplastic large cell lymphoma in childhood. (PMID: 19243819) Kitamura N. … Kiyokawa N. (Leuk. Res. 2009) 3 23
  4. Granulysin induces cathepsin B release from lysosomes of target tumor cells to attack mitochondria through processing of bid leading to Necroptosis. (PMID: 19454696) Zhang H. … Fan Z. (J. Immunol. 2009) 3 23
  5. Induction of granulysin in CD8+ T cells by IL-21 and IL-15 is suppressed by human immunodeficiency virus-1. (PMID: 19687290) Hogg A.E. … Endsley J.J. (J. Leukoc. Biol. 2009) 3 23

Products for GNLY Gene

Sources for GNLY Gene