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Aliases for GNLY Gene

Aliases for GNLY Gene

  • Granulysin 2 3
  • TLA519 3 4 6
  • T-Lymphocyte Activation Gene 519 2 3
  • T-Cell Activation Protein 519 3 4
  • Lymphokine LAG-2 3 4
  • D2S69E 3 6
  • LAG2 3 4
  • NKG5 3 4
  • Lymphocyte-Activation Gene 2 3
  • Protein NKG5 4
  • LAG-2 3
  • 519 3

External Ids for GNLY Gene

Previous HGNC Symbols for GNLY Gene

  • LAG2

Previous GeneCards Identifiers for GNLY Gene

  • GC02P085816
  • GC02P086215
  • GC02P085895
  • GC02P085834
  • GC02P085912

Summaries for GNLY Gene

Entrez Gene Summary for GNLY Gene

  • The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for GNLY Gene

GNLY (Granulysin) is a Protein Coding gene. Diseases associated with GNLY include folliculitis and hemophagocytic lymphohistiocytosis.

UniProtKB/Swiss-Prot for GNLY Gene

  • Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis

Gene Wiki entry for GNLY Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNLY Gene

Genomics for GNLY Gene

Regulatory Elements for GNLY Gene

Genomic Location for GNLY Gene

Start:
85,685,175 bp from pter
End:
85,698,854 bp from pter
Size:
13,680 bases
Orientation:
Plus strand

Genomic View for GNLY Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNLY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNLY Gene

Proteins for GNLY Gene

  • Protein details for GNLY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22749-GNLY_HUMAN
    Recommended name:
    Granulysin
    Protein Accession:
    P22749
    Secondary Accessions:
    • P09325
    • Q6GU08

    Protein attributes for GNLY Gene

    Size:
    145 amino acids
    Molecular mass:
    16374 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GNLY Gene

    Alternative splice isoforms for GNLY Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GNLY Gene

Proteomics data for GNLY Gene at MOPED

Post-translational modifications for GNLY Gene

  • A 9 kDa form is produced by proteolytic processing of a 15 kDa protein.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNLY Gene

Antibody Products

No data available for DME Specific Peptides for GNLY Gene

Domains for GNLY Gene

Protein Domains for GNLY Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P22749

UniProtKB/Swiss-Prot:

GNLY_HUMAN :
  • P22749
Domain:
  • Contains 1 saposin B-type domain.
genes like me logo Genes that share domains with GNLY: view

No data available for Gene Families for GNLY Gene

Function for GNLY Gene

Molecular function for GNLY Gene

GENATLAS Biochemistry: Granulysin,expressed by cytolytic T-lymphocytes and NK cells,located in cytotoxic granules,involved in immunity against intracellular infection against M tuberculosis and other pathogens
UniProtKB/Swiss-Prot Function: Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis
UniProtKB/Swiss-Prot Induction: By T-cell growth factor and IL2/interleukin-2

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GNLY Gene

Localization for GNLY Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNLY Gene

Secreted. Note=Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNLY Gene COMPARTMENTS Subcellular localization image for GNLY gene
Compartment Confidence
extracellular 5
lysosome 2
vacuole 2
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GNLY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 2212946
genes like me logo Genes that share ontologies with GNLY: view

Pathways for GNLY Gene

SuperPathways for GNLY Gene

No Data Available

Interacting Proteins for GNLY Gene

Gene Ontology (GO) - Biological Process for GNLY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 9756476
GO:0031640 killing of cells of other organism IEA --
GO:0042742 defense response to bacterium IEA --
GO:0050832 defense response to fungus IEA --
genes like me logo Genes that share ontologies with GNLY: view

No data available for Pathways by source for GNLY Gene

Compounds for GNLY Gene

(1) Drugbank Compounds for GNLY Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
3[N-Morpholino]Propane Sulfonic Acid
target

(16) Novoseek inferred chemical compound relationships for GNLY Gene

Compound -log(P) Hits PubMed IDs
concanamycin a 70.3 2
ddvp 65.7 6
rantes 33.5 3
chromium 17.7 2
ionomycin 12 1
genes like me logo Genes that share compounds with GNLY: view

Transcripts for GNLY Gene

Unigene Clusters for GNLY Gene

Granulysin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNLY

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNLY Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - - - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: - - -
SP5: - - - - - -
SP6: - -
SP7: - - - - - - - - -
SP8: - - - - - -
SP9: - - - -
SP10:
SP11:
SP12: - -
SP13:

Relevant External Links for GNLY Gene

GeneLoc Exon Structure for
GNLY
ECgene alternative splicing isoforms for
GNLY

Expression for GNLY Gene

mRNA expression in normal human tissues for GNLY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNLY Gene

This gene is overexpressed in Whole Blood (41.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for GNLY Gene

SOURCE GeneReport for Unigene cluster for GNLY Gene Hs.105806

mRNA Expression by UniProt/SwissProt for GNLY Gene

P22749-GNLY_HUMAN
Tissue specificity: Expressed in natural killer and T-cells
genes like me logo Genes that share expressions with GNLY: view

In Situ Assay Products

Orthologs for GNLY Gene

This gene was present in the common ancestor of mammals.

Orthologs for GNLY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNLY 35
  • 97.47 (n)
  • 93.79 (a)
GNLY 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 38 (a)
OneToMany
-- 36
  • 30 (a)
OneToMany
-- 36
  • 38 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 30 (a)
OneToMany
-- 36
  • 30 (a)
OneToMany
Species with no ortholog for GNLY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GNLY Gene

ENSEMBL:
Gene Tree for GNLY (if available)
TreeFam:
Gene Tree for GNLY (if available)

Paralogs for GNLY Gene

No data available for Paralogs for GNLY Gene

Variants for GNLY Gene

Sequence variations from dbSNP and Humsavar for GNLY Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7908 -- 85,698,633(+) GGAAC(C/G)TCAGC utr-variant-3-prime, reference, missense
rs11127 - 85,697,606(+) AGTTA(C/T)CCAGG reference, missense, intron-variant
rs12845 -- 85,698,725(+) TCTCA(C/G)GAGAA utr-variant-3-prime, reference, missense
rs1437742 -- 85,697,776(+) CCAGC(A/T)TGGGA intron-variant
rs1437743 -- 85,697,866(+) GTGGT(C/T)GTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNLY Gene

Variant ID Type Subtype PubMed ID
dgv4202n71 CNV Loss 21882294
nsv874465 CNV Loss 21882294
nsv2812 CNV Loss 18451855
dgv4203n71 CNV Loss 21882294
esv23053 CNV Gain 19812545

Relevant External Links for GNLY Gene

HapMap Linkage Disequilibrium report
GNLY

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNLY Gene

Disorders for GNLY Gene

(2) University of Copenhagen DISEASES for GNLY Gene

(13) Novoseek inferred disease relationships for GNLY Gene

Disease -log(P) Hits PubMed IDs
tuberculosis 60.2 25
mycobacterial infection 33.3 2
cell damage 24.4 4
tumors 20.6 20
necrosis 6.15 3

Relevant External Links for GNLY

Genetic Association Database (GAD)
GNLY
Human Genome Epidemiology (HuGE) Navigator
GNLY
genes like me logo Genes that share disorders with GNLY: view

No data available for UniProtKB/Swiss-Prot for GNLY Gene

Publications for GNLY Gene

  1. An antimicrobial activity of cytolytic T cells mediated by granulysin. (PMID: 9756476) Stenger S. … Modlin R.L. (Science 1998) 3 4 23
  2. Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells. (PMID: 10644038) Krensky A.M. (Biochem. Pharmacol. 2000) 3 4 23
  3. Biosynthesis of granulysin, a novel cytolytic molecule. (PMID: 10449094) Hanson D.A. … Krensky A.M. (Mol. Immunol. 1999) 3 4 23
  4. Granulysin crystal structure and a structure-derived lytic mechanism. (PMID: 12488100) Anderson D.H. … Eisenberg D. (J. Mol. Biol. 2003) 3 4 23
  5. A cDNA clone expressed in natural killer and T cells that likely encodes a secreted protein. (PMID: 2212946) Yabe T. … Houchins J.P. (J. Exp. Med. 1990) 2 3 4

Products for GNLY Gene

Sources for GNLY Gene

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