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Aliases for GNLY Gene

Aliases for GNLY Gene

  • Granulysin 2 3 3 5
  • T-Lymphocyte Activation Gene 519 2 3
  • T-Cell Activation Protein 519 3 4
  • Lymphokine LAG-2 3 4
  • TLA519 3 4
  • LAG2 3 4
  • NKG5 3 4
  • Lymphocyte-Activation Gene 2 3
  • Protein NKG5 4
  • D2S69E 3
  • LAG-2 3

External Ids for GNLY Gene

Previous HGNC Symbols for GNLY Gene

  • LAG2

Previous GeneCards Identifiers for GNLY Gene

  • GC02P085816
  • GC02P086215
  • GC02P085895
  • GC02P085834
  • GC02P085912

Summaries for GNLY Gene

Entrez Gene Summary for GNLY Gene

  • The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for GNLY Gene

GNLY (Granulysin) is a Protein Coding gene. Diseases associated with GNLY include Tuberculosis and Erythematosquamous Dermatosis. Among its related pathways are Defensins and Innate Immune System.

UniProtKB/Swiss-Prot for GNLY Gene

  • Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.

Gene Wiki entry for GNLY Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNLY Gene

Genomics for GNLY Gene

Regulatory Elements for GNLY Gene

Enhancers for GNLY Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G085709 1.6 FANTOM5 Ensembl ENCODE dbSUPER 33.6 +26.4 26446 4.7 PKNOX1 SIN3A RAD21 RARA YY1 ZNF335 HSF1 FOS EGR2 CEBPB GNLY ATOH8 LOC100130649 SFTPB LOC284950 GC02M085730 RNU1-38P
GH02G085701 2 FANTOM5 Ensembl ENCODE dbSUPER 23.5 +19.3 19264 6.7 HDGF FOXA2 PKNOX1 CREB3L1 ARNT WRNIP1 SIN3A ZNF2 YY1 ZNF766 ATOH8 GNLY LOC100130649 SFTPB C2orf68 USP39 RNU1-38P LOC284950 SH2D6 GC02M085730
GH02G085693 1.1 ENCODE dbSUPER 17.2 +9.0 9005 1.0 HDAC1 ATF1 PKNOX1 TBL1XR1 ARNT RAD21 YY1 ZNF335 TCF12 ZNF766 GNLY SFTPB RNU1-38P ATOH8 LOC284950 LOC100130649 GC02M085730
GH02G085680 1.1 ENCODE dbSUPER 15.2 -3.7 -3659 2.4 FOXA2 THRB EGR1 RCOR1 FOS CREM EGR2 SMARCC1 USF2 CEBPB GNLY RNU1-38P ATOH8 LOC284950 LOC105374842
GH02G085708 1.4 FANTOM5 Ensembl dbSUPER 11.4 +23.7 23743 0.6 HDAC1 PKNOX1 SIN3A FEZF1 ZNF335 TCF12 GATA2 EGR1 FOS DEK ATOH8 SFTPB GNLY LOC284950 GC02M085730 RNU1-38P LOC100130649
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GNLY on UCSC Golden Path with GeneCards custom track

Genomic Location for GNLY Gene

Chromosome:
2
Start:
85,685,175 bp from pter
End:
85,698,854 bp from pter
Size:
13,680 bases
Orientation:
Plus strand

Genomic View for GNLY Gene

Genes around GNLY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNLY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNLY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNLY Gene

Proteins for GNLY Gene

  • Protein details for GNLY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22749-GNLY_HUMAN
    Recommended name:
    Granulysin
    Protein Accession:
    P22749
    Secondary Accessions:
    • P09325
    • Q6GU08

    Protein attributes for GNLY Gene

    Size:
    145 amino acids
    Molecular mass:
    16374 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GNLY Gene

    Alternative splice isoforms for GNLY Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GNLY Gene

Post-translational modifications for GNLY Gene

  • A 9 kDa form is produced by proteolytic processing of a 15 kDa protein.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for GNLY

No data available for DME Specific Peptides for GNLY Gene

Domains & Families for GNLY Gene

Protein Domains for GNLY Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GNLY: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GNLY Gene

Function for GNLY Gene

Molecular function for GNLY Gene

GENATLAS Biochemistry:
Granulysin,expressed by cytolytic T-lymphocytes and NK cells,located in cytotoxic granules,involved in immunity against intracellular infection against M tuberculosis and other pathogens
UniProtKB/Swiss-Prot Function:
Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.
UniProtKB/Swiss-Prot Induction:
By T-cell growth factor and IL2/interleukin-2.
genes like me logo Genes that share phenotypes with GNLY: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GNLY Gene

Localization for GNLY Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNLY Gene

Secreted. Note=Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNLY gene
Compartment Confidence
extracellular 5
cytosol 2
lysosome 2
plasma membrane 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GNLY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 2212946
GO:0044194 colocalizes_with cytolytic granule IDA 9756476
GO:0097013 phagocytic vesicle lumen TAS --
genes like me logo Genes that share ontologies with GNLY: view

Pathways & Interactions for GNLY Gene

genes like me logo Genes that share pathways with GNLY: view

Pathways by source for GNLY Gene

1 BioSystems pathway for GNLY Gene
3 Reactome pathways for GNLY Gene

Interacting Proteins for GNLY Gene

Selected Interacting proteins: P22749-GNLY_HUMAN for GNLY Gene via IID

Gene Ontology (GO) - Biological Process for GNLY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002818 intracellular defense response IDA 9756476
GO:0006968 cellular defense response TAS --
GO:0019730 antimicrobial humoral response TAS --
GO:0031640 killing of cells of other organism IEA,IDA 9756476
GO:0042742 defense response to bacterium IEA,IDA 9756476
genes like me logo Genes that share ontologies with GNLY: view

No data available for SIGNOR curated interactions for GNLY Gene

Drugs & Compounds for GNLY Gene

(11) Drugs for GNLY Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
3[N-Morpholino]Propane Sulfonic Acid Experimental Pharma Target 0

(6) Additional Compounds for GNLY Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GNLY: view

Transcripts for GNLY Gene

Unigene Clusters for GNLY Gene

Granulysin:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNLY Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - - - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: - - -
SP5: - - - - - -
SP6: - -
SP7: - - - - - - - - -
SP8: - - - - - -
SP9: - - - -
SP10:
SP11:
SP12: - -
SP13:

Relevant External Links for GNLY Gene

GeneLoc Exon Structure for
GNLY
ECgene alternative splicing isoforms for
GNLY

Expression for GNLY Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GNLY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNLY Gene

This gene is overexpressed in Whole Blood (x41.8).

Protein differential expression in normal tissues from HIPED for GNLY Gene

This gene is overexpressed in NK cells (38.9) and Peripheral blood mononuclear cells (22.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GNLY Gene



Protein tissue co-expression partners for GNLY Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GNLY Gene:

GNLY

SOURCE GeneReport for Unigene cluster for GNLY Gene:

Hs.105806

mRNA Expression by UniProt/SwissProt for GNLY Gene:

P22749-GNLY_HUMAN
Tissue specificity: Expressed in natural killer and T-cells.

Evidence on tissue expression from TISSUES for GNLY Gene

  • Blood(3.3)
  • Spleen(2.6)
  • Bone marrow(2)
  • Lung(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with GNLY: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GNLY Gene

Orthologs for GNLY Gene

This gene was present in the common ancestor of mammals.

Orthologs for GNLY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNLY 34 35
  • 97.47 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 38 (a)
OneToMany
-- 35
  • 38 (a)
OneToMany
-- 35
  • 30 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 30 (a)
OneToMany
-- 35
  • 30 (a)
OneToMany
Species where no ortholog for GNLY was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GNLY Gene

ENSEMBL:
Gene Tree for GNLY (if available)
TreeFam:
Gene Tree for GNLY (if available)

Paralogs for GNLY Gene

No data available for Paralogs for GNLY Gene

Variants for GNLY Gene

Sequence variations from dbSNP and Humsavar for GNLY Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000111433 -- 85,693,281(+) TGCCT(A/G)TAATC upstream-variant-2KB
rs1000163737 -- 85,693,535(+) CTCTG(C/T)CTCAA upstream-variant-2KB
rs1000436291 -- 85,698,946(+) CTCAC(C/T)ACAGC downstream-variant-500B
rs1000461846 -- 85,698,341(+) GCTGG(A/C)AGATC intron-variant
rs1000750824 -- 85,693,637(+) CAGCC(A/G)GGGTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GNLY Gene

Variant ID Type Subtype PubMed ID
esv23053 CNV gain 19812545
nsv2812 CNV deletion 18451855
nsv582369 CNV loss 21841781

Variation tolerance for GNLY Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNLY Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNLY

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNLY Gene

Disorders for GNLY Gene

MalaCards: The human disease database

(4) MalaCards diseases for GNLY Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tuberculosis
  • kochs disease
erythematosquamous dermatosis
  • erythematosquamous dermatosis nos
hemophagocytic lymphohistiocytosis
  • haemophagocytic syndrome
hypersensitivity syndrome, carbamazepine-induced
  • toxic epidermal necrolysis
- elite association - COSMIC cancer census association via MalaCards
Search GNLY in MalaCards View complete list of genes associated with diseases

Relevant External Links for GNLY

Genetic Association Database (GAD)
GNLY
Human Genome Epidemiology (HuGE) Navigator
GNLY
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNLY
genes like me logo Genes that share disorders with GNLY: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNLY Gene

Publications for GNLY Gene

  1. Granulysin crystal structure and a structure-derived lytic mechanism. (PMID: 12488100) Anderson D.H. … Eisenberg D. (J. Mol. Biol. 2003) 3 4 22 64
  2. Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells. (PMID: 10644038) Krensky A.M. (Biochem. Pharmacol. 2000) 3 4 22 64
  3. Biosynthesis of granulysin, a novel cytolytic molecule. (PMID: 10449094) Hanson D.A. … Krensky A.M. (Mol. Immunol. 1999) 3 4 22 64
  4. An antimicrobial activity of cytolytic T cells mediated by granulysin. (PMID: 9756476) Stenger S. … Modlin R.L. (Science 1998) 3 4 22 64
  5. A cDNA clone expressed in natural killer and T cells that likely encodes a secreted protein. (PMID: 2212946) Yabe T. … Houchins J.P. (J. Exp. Med. 1990) 2 3 4 64

Products for GNLY Gene

Sources for GNLY Gene

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