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GNLY Gene

protein-coding   GIFtS: 55
GCID: GC02P085912

Granulysin


(Previous symbol: LAG2)
  See GNLY-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
granulysin1 2     T-Cell Activation Protein 5192 3
LAG21 2 3     D2S69E2 5
TLA5192 3 5     5192
T-Lymphocyte Activation Gene 5191 2     LAG-22
Lymphokine LAG-22 3     Lymphocyte-Activation Gene 22
NKG52 3     Protein NKG53

External Ids:    HGNC: 44141   Entrez Gene: 105782   Ensembl: ENSG000001155237   OMIM: 1888555   UniProtKB: P227493   
ORGUL members:         

Export aliases for GNLY gene to outside databases

Previous GC identifers: GC02P085816 GC02P086215 GC02P085895 GC02P085834


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GNLY Gene:
The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic
granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules
of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis
and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified.
(provided by RefSeq, Jul 2008)

GeneCards Summary for GNLY Gene:
GNLY (granulysin) is a protein-coding gene. Diseases associated with GNLY include folliculitis, and measles.

UniProtKB/Swiss-Prot: GNLY_HUMAN, P22749
Function: Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes,
including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis

Gene Wiki entry for GNLY Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GNLY gene promoter:
         GR   AP-1   ATF-2   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNLY promoter sequence
   Search Chromatin IP Primers for GNLY

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GNLY


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p12-q11

GNLY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNLY gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P085912:  view genomic region     (about GC identifiers)

Start:
85,912,298 bp from pter      End:
85,925,977 bp from pter
Size:
13,680 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GNLY_HUMAN, P22749 (See protein sequence)
Recommended Name: Granulysin precursor  
Size: 145 amino acids; 16374 Da
1 PDB 3D structure from and Proteopedia for GNLY:
1L9L (3D)    
Secondary accessions: P09325 Q6GU08
Alternative splicing: 2 isoforms:  P22749-1   P22749-2   

Explore the universe of human proteins at neXtProt for GNLY: NX_P22749

Explore proteomics data for GNLY at MOPED

Post-translational modifications: 

  • A 9 kDa form is produced by proteolytic processing of a 15 kDa protein1
  • Modification sites at neXtProt

  • See GNLY Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_006424.2  NP_036615.2  

    ENSEMBL proteins: 
     ENSP00000263863   ENSP00000436423   ENSP00000387116   ENSP00000434467  

    GNLY Human Recombinant Protein Products:

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    Search eBioscience for Proteins for GNLY 

    GNLY Antibody Products:

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    LSBio Antibodies in human, mouse, rat for GNLY

    GNLY Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR008138 SapB_2
     IPR011001 Saposin-like
     IPR008139 SaposinB

    Graphical View of Domain Structure for InterPro Entry P22749

    ProtoNet protein and cluster: P22749

    1 Blocks protein domain: IPB008139 Saposin B

    UniProtKB/Swiss-Prot: GNLY_HUMAN, P22749
    Similarity: Contains 1 saposin B-type domain


    Find genes that share domains with GNLY           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GNLY_HUMAN, P22749
    Function: Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes,
    including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis
    Induction: By T-cell growth factor and IL2/interleukin-2

         Genatlas biochemistry entry for GNLY:
    Granulysin,expressed by cytolytic T-lymphocytes and NK cells,located in cytotoxic granules,involved in immunity
    against intracellular infection against M tuberculosis and other pathogens

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GNLY
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GNLY

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GNLY
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GNLY

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    Predesigned siRNA for gene silencing in human, mouse, rat GNLY

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    Sino Biological Human cDNA Clone for GNLY
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNLY

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNLY


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GNLY_HUMAN, P22749: Secreted. Note=Located in the cytotoxic granules of T-cells, which are released upon antigen
    stimulation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    lysosome2
    vacuole2
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS2212946

    Find genes that share ontologies with GNLY           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GNLY
    Interactions:

        Search GeneGlobe Interaction Network for GNLY

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006968cellular defense response TAS9756476
    GO:0031640killing of cells of other organism IEA--
    GO:0042742defense response to bacterium IEA--
    GO:0050832defense response to fungus IEA--

    Find genes that share ontologies with GNLY           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GNLY

    1 DrugBank Compound for GNLY    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3[N-Morpholino]Propane Sulfonic Acid-- --target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for GNLY gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    concanamycin a 70.3 2 10449094 (1), 12421959 (1)
    ddvp 65.7 9 16002202 (4), 16873099 (1), 18063463 (1)
    rantes 33.5 5 15843520 (1), 19254247 (1), 15223905 (1)
    chromium 17.7 2 16873099 (1), 16002202 (1)
    ionomycin 12 1 9538144 (1)
    ceramide 9.32 5 9712041 (3), 11466337 (2)
    cholesterol 0 1 17206515 (1)
    lysine 0 3 11120840 (2), 15778306 (1)
    oligonucleotide 0 3 16036810 (1), 17695285 (1)
    estradiol 0 1 18394317 (1)



    Find genes that share compounds with GNLY           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GNLY gene (2 alternative transcripts): 
    NM_006433.3  NM_012483.2  

    Unigene Cluster for GNLY:

    Granulysin
    Hs.105806  [show with all ESTs]
    Unigene Representative Sequence: BM922716
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000488945 ENST00000263863(uc002sql.4) ENST00000489214 ENST00000482900
    ENST00000464298 ENST00000470974 ENST00000489980(uc010fgp.3 uc010ysx.2)
    ENST00000524600 ENST00000533041 ENST00000534351 ENST00000409696 ENST00000491234
    ENST00000531685 ENST00000526018
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidGNLY 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GNLY
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    GenScript: all cDNA clones in your preferred vector (see all 2): GNLY (NM_012483)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNLY
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNLY
    Primer
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    OriGene qPCR primer pairs and template standards for GNLY
    OriGene qSTAR qPCR primer pairs in human, mouse for GNLY
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat GNLY
      QuantiTect SYBR Green Assays in human, mouse, rat GNLY
      QuantiFast Probe-based Assays in human, mouse, rat GNLY

    Additional mRNA sequence: 

    AK296106.1 AK304728.1 AK308781.1 AK310057.1 AK311012.1 AK311537.1 AK311538.1 AK311657.1 
    BC023576.2 CR541859.1 X05044.1 X54101.1 

    10 DOTS entries:

    DT.212691  DT.75105988  DT.95358882  DT.95197828  DT.97795884  DT.86846626  DT.40294595  DT.95358881 
    DT.120993320  DT.40132307 

    Selected AceView cDNA sequences (see all 91):

    CB216891 BF848763 BC023576 X54101 NM_006433 BC063245 AW404745 CR541859 
    BU753489 AI784114 AI288685 BG686017 AA383970 BQ013570 BI905826 BQ010869 
    BQ015614 BQ013787 AA586798 BQ013000 BM681833 AA576437 BQ013407 AW950869 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GNLY (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                            -     -     -     -     -     -                       -     -     -     -     -     -     -                     
    SP2:                                                                    -     -                       -     -     -     -     -                                 
    SP3:                                                                    -     -                       -     -     -     -     -     -     -                     
    SP4:                                                              -     -     -                                                                                 
    SP5:                                                                                                  -     -     -     -     -     -                           


    ECgene alternative splicing isoforms for GNLY

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GNLY expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAGGTATC
    GNLY Expression
    About this image


    GNLY expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Uterus (Reproductive System)
     
     Stomach (Gastrointestinal Tract)
     
     Spleen (Hematopoietic System)
    GNLY Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GNLY Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.105806

    UniProtKB/Swiss-Prot: GNLY_HUMAN, P22749
    Tissue specificity: Expressed in natural killer and T-cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNLY

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for GNLY gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    --
    Uncharacterized protein
    30(a)
    30(a)
    many → 1
    many → 1
    17(39326012-39353979)
    AAEX03023386.1(3908-7947)


    ENSEMBL Gene Tree for GNLY (if available)
    TreeFam Gene Tree for GNLY (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GNLY (see all 202)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs787351011,2
    C,F--85919544(+) GTTAGG/AGTAGG 2 -- us2k12Minor allele frequency- A:0.04WA NA 238
    rs1395464141,2
    --85919578(+) GAGTCA/GTAGGG 2 -- us2k10--------
    rs1444234571,2
    --85919692(+) TTGCCA/GGTTGG 2 -- us2k10--------
    rs1997915581,2
    C--85919788(-) GGCTGG/TCTTGT 2 -- us2k10--------
    rs1845917861,2
    C--85919827(+) TCACCA/GGAAAG 2 -- us2k10--------
    rs1455142851,2
    --85919849(+) ATTTT-/CCACAG 2 -- us2k10--------
    rs2020244601,2
    C--85919849(+) AATTTC/TCACAG 2 -- us2k10--------
    rs1473766851,2
    C--85920048(+) AGGATC/TGCTTG 2 -- us2k10--------
    rs1905191531,2
    --85920049(+) GGATCC/GCTTGA 2 -- us2k10--------
    rs1396098141,2
    --85920061(+) TCCAGG/TAGTTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for GNLY (85912298 - 85925977 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GNLY:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4203n71CNV Loss21882294
    nsv2812CNV Loss18451855
    dgv4202n71CNV Loss21882294
    nsv874465CNV Loss21882294
    esv23053CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GNLY
    DNA2.0 Custom Variant and Variant Library Synthesis for GNLY

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 188855    OMIM disorders: --

    4 diseases for GNLY:    
    About MalaCards
    folliculitis    measles    tuberculosis    primary biliary cirrhosis

    2 diseases from the University of Copenhagen DISEASES database for GNLY:
    Tuberculosis     Stevens-Johnson syndrome

    Find genes that share disorders with GNLY           About GenesLikeMe

    Selected Novoseek inferred disease relationships for GNLY gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberculosis 60.2 30 17445478 (2), 11574927 (2), 16301655 (2), 9756476 (2) (see all 18)
    mycobacterial infection 33.3 2 15149502 (1), 16081226 (1)
    cell damage 24.4 5 11418670 (1), 19111751 (1), 14499265 (1), 16388735 (1)
    tumors 20.6 24 19454696 (3), 17182542 (3), 15616319 (1), 15843520 (1) (see all 16)
    necrosis 6.15 4 20196946 (1), 9538144 (1), 19474732 (1)
    infectious disease 4.21 4 11175847 (2), 15294977 (1)
    measles 1.86 5 16036810 (3), 17695285 (1)
    immunodeficiency 1.19 2 17038537 (1), 19687290 (1)
    virus infection 0 1 12884856 (1)
    aids 0 1 12421959 (1)

    Genetic Association Database (GAD): GNLY
    Human Genome Epidemiology (HuGE) Navigator: GNLY (4 documents)

    Export disorders for GNLY gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GNLY gene, integrated from 10 sources (see all 158):
    (articles sorted by number of sources associating them with GNLY)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cDNA clone expressed in natural killer and T cells that likely encodes a secreted protein. (PubMed id 2212946)1, 2, 3 Yabe T.... Houchins J.P. (J. Exp. Med. 1990)
    2. The isolation and sequence of a novel gene from a human functional T cell line. (PubMed id 2434598)1, 2, 3 Jongstra J.... Krensky A.M. (J. Exp. Med. 1987)
    3. Granulysin crystal structure and a structure-derived lytic mechanism. (PubMed id 12488100)1, 2, 9 Anderson D.H.... Eisenberg D. (J. Mol. Biol. 2003)
    4. Biosynthesis of granulysin, a novel cytolytic molecule. (PubMed id 10449094)1, 2, 9 Hanson D.A.... Krensky A.M. (Mol. Immunol. 1999)
    5. Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells. (PubMed id 10644038)1, 2, 9 Krensky A.M. (Biochem. Pharmacol. 2000)
    6. An antimicrobial activity of cytolytic T cells mediated by granulysin. (PubMed id 9756476)1, 2, 9 Stenger S.... Modlin R.L. (Science 1998)
    7. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    8. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    9. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10578 HGNC: 4414 AceView: GNLY Ensembl:ENSG00000115523 euGenes: HUgn10578
    ECgene: GNLY H-InvDB: GNLY

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GNLY Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GNLY gene:
    Search GeneIP for patents involving GNLY

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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