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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNLY Gene

protein-coding   GIFtS: 55
GCID: GC02P085912

Granulysin


(Previous symbol: LAG2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
granulysin1 2     T-Cell Activation Protein 5192 3
LAG21 2 3     D2S69E2 5
TLA5192 3 5     5192
T-Lymphocyte Activation Gene 5191 2     LAG-22
Lymphokine LAG-22 3     Lymphocyte-Activation Gene 22
NKG52 3     Protein NKG53

External Ids:    HGNC: 44141   Entrez Gene: 105782   Ensembl: ENSG000001155237   OMIM: 1888555   UniProtKB: P227493   

Export aliases for GNLY gene to outside databases

Previous GC identifers: GC02P085816 GC02P086215 GC02P085895 GC02P085834


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GNLY Gene:
The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic
granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules
of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis
and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified.
(provided by RefSeq, Jul 2008)

GeneCards Summary for GNLY Gene: 
GNLY (granulysin) is a protein-coding gene. Diseases associated with GNLY include folliculitis, and spondylocostal dysostosis.

UniProtKB/Swiss-Prot: GNLY_HUMAN, P22749
Function: Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes,
including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis

Gene Wiki entry for GNLY Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNLY gene promoter:
         GR   AP-1   ATF-2   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNLY promoter sequence
   Search SABiosciences Chromatin IP Primers for GNLY

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNLY


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p12-q11

GNLY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNLY gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P085912:  view genomic region     (about GC identifiers)

Start:
85,912,298 bp from pter      End:
85,925,977 bp from pter
Size:
13,680 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GNLY_HUMAN, P22749 (See protein sequence)
Recommended Name: Granulysin precursor  
Size: 145 amino acids; 16374 Da
Subcellular location: Secreted. Note=Located in the cytotoxic granules of T-cells, which are released upon antigen
stimulation
1 PDB 3D structure from and Proteopedia for GNLY:
1L9L (3D)    
Secondary accessions: P09325 Q6GU08
Alternative splicing: 2 isoforms:  P22749-1   P22749-2   

Explore the universe of human proteins at neXtProt for GNLY: NX_P22749

Explore proteomics data for GNLY at MOPED 

Post-translational modifications:

  • UniProtKB: A 9 kDa form is produced by proteolytic processing of a 15 kDa protein
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P22749

  • GNLY Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GNLY Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_006424.2  NP_036615.2  

    ENSEMBL proteins: 
     ENSP00000263863   ENSP00000436423   ENSP00000387116   ENSP00000434467  

    Human Recombinant Protein Products for GNLY: 
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    OriGene Purified Protein for GNLY
    OriGene Protein Over-expression Lysate for GNLY
    OriGene MassSpec for GNLY 
    OriGene Custom Protein Services for GNLY
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    Novus Biologicals GNLY Proteins
    Novus Biologicals GNLY Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for GNLY
    Cloud-Clone Corp. Proteins for GNLY 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS2212946

    GNLY for ontologies           About GeneDecksing



    GNLY Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for GNLY 

    Assay Products for GNLY: 
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    Cloud-Clone Corp. ELISAs for GNLY 
    Cloud-Clone Corp. CLIAs for GNLY


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR008138 SapB_2
     IPR011001 Saposin-like
     IPR008139 SaposinB

    Graphical View of Domain Structure for InterPro Entry P22749

    ProtoNet protein and cluster: P22749

    1 Blocks protein domain: IPB008139 Saposin B

    UniProtKB/Swiss-Prot: GNLY_HUMAN, P22749
    Similarity: Contains 1 saposin B-type domain


    GNLY for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GNLY_HUMAN, P22749
    Function: Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes,
    including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis
    Induction: By T-cell growth factor and IL2/interleukin-2

         Genatlas biochemistry entry for GNLY:
    Granulysin,expressed by cytolytic T-lymphocytes and NK cells,located in cytotoxic granules,involved in immunity
    against intracellular infection against M tuberculosis and other pathogens

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GNLY 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GNLY

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GNLY 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GNLY 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNLY
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GNLY
    SwitchGear 3'UTR luciferase reporter plasmidGNLY 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GNLY
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNLY

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of GNLY

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GNLY (see all 10)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GNLY (NM_012483)
    Sino Biological Human cDNA Clone for GNLY
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNLY
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNLY
    Sirion Biotech Customized lentivirus for stable overexpression of GNLY 
                         Customized lentivirus expression plasmids for stable overexpression of GNLY 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNLY


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GNLY

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006968cellular defense response TAS9756476
    GO:0031640killing of cells of other organism IEA--
    GO:0042742defense response to bacterium IEA--
    GO:0050832defense response to fungus IEA--

    GNLY for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GNLY for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GNLY

    1 DrugBank Compound for GNLY    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3[N-Morpholino]Propane Sulfonic Acid-- --target--17139284 17016423

    10/16 Novoseek inferred chemical compound relationships for GNLY gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    concanamycin a 70.3 2 10449094 (1), 12421959 (1)
    ddvp 65.7 9 16002202 (4), 16873099 (1), 18063463 (1)
    rantes 33.5 5 15843520 (1), 19254247 (1), 15223905 (1)
    chromium 17.7 2 16873099 (1), 16002202 (1)
    ionomycin 12 1 9538144 (1)
    ceramide 9.32 5 9712041 (3), 11466337 (2)
    cholesterol 0 1 17206515 (1)
    lysine 0 3 11120840 (2), 15778306 (1)
    oligonucleotide 0 3 16036810 (1), 17695285 (1)
    estradiol 0 1 18394317 (1)

    Search CenterWatch for drugs/clinical trials and news about GNLY

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GNLY gene (2 alternative transcripts): 
    NM_006433.3  NM_012483.2  

    Unigene Cluster for GNLY:

    Granulysin
    Hs.105806  [show with all ESTs]
    Unigene Representative Sequence: BM922716
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000488945 ENST00000263863(uc002sql.4) ENST00000489214 ENST00000482900
    ENST00000464298 ENST00000470974 ENST00000489980(uc010fgp.3 uc010ysx.2)
    ENST00000524600 ENST00000533041 ENST00000534351 ENST00000409696 ENST00000491234
    ENST00000531685 ENST00000526018
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GNLY
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GNLY
    SwitchGear 3'UTR luciferase reporter plasmidGNLY 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GNLY
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GNLY
    Clone
    Products:
         
    OriGene clones in human, mouse for GNLY (see all 10)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GNLY (NM_012483)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GNLY
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GNLY
    Sirion Biotech Customized lentivirus for stable overexpression of GNLY 
                         Customized lentivirus expression plasmids for stable overexpression of GNLY 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GNLY
    OriGene qSTAR qPCR primer pairs in human, mouse for GNLY
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat GNLY
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GNLY
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GNLY

    Additional mRNA sequence: 

    AK296106.1 AK304728.1 AK308781.1 AK310057.1 AK311012.1 AK311537.1 AK311538.1 AK311657.1 
    BC023576.2 CR541859.1 X05044.1 X54101.1 

    10 DOTS entries:

    DT.212691  DT.75105988  DT.95358882  DT.95197828  DT.97795884  DT.86846626  DT.40294595  DT.95358881 
    DT.120993320  DT.40132307 

    24/91 AceView cDNA sequences (see all 91):

    BC063245 AW404745 CB216891 BC023576 NM_006433 X54101 CR541859 BF848763 
    AI123412 BQ013570 AI784114 BI905826 AA383970 BG686017 BQ015614 AA576437 
    BQ013787 AI309383 BQ010869 BI835883 BM922350 AI288685 BQ013407 BM681833 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for GNLY (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                            -     -     -     -     -     -                       -     -     -     -     -     -     -                     
    SP2:                                                                    -     -                       -     -     -     -     -                                 
    SP3:                                                                    -     -                       -     -     -     -     -     -     -                     
    SP4:                                                              -     -     -                                                                                 
    SP5:                                                                                                  -     -     -     -     -     -                           


    ECgene alternative splicing isoforms for GNLY

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNLY expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAGGTATC
    GNLY Expression
    About this image


    See GNLY Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNLY

    SOURCE GeneReport for Unigene cluster: Hs.105806

    UniProtKB/Swiss-Prot: GNLY_HUMAN, P22749
    Tissue specificity: Expressed in natural killer and T-cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GNLY

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for GNLY gene from 1/3 species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    --
    --
    30(a)
    30(a)
    many → 1
    many → 1
    17(39326012-39353979)
    AAEX03023386.1(3908-7947)


    ENSEMBL Gene Tree for GNLY (if available)
    TreeFam Gene Tree for GNLY (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/202 SNPs in GNLY are shown (see all 202)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs787351011,2
    C,F--85919544(+) GTTAGG/AGTAGG 2 -- us2k12Minor allele frequency- A:0.04WA NA 238
    rs1395464141,2
    --85919578(+) GAGTCA/GTAGGG 2 -- us2k10--------
    rs1444234571,2
    --85919692(+) TTGCCA/GGTTGG 2 -- us2k10--------
    rs1997915581,2
    C--85919788(-) GGCTGG/TCTTGT 2 -- us2k10--------
    rs1845917861,2
    C--85919827(+) TCACCA/GGAAAG 2 -- us2k10--------
    rs1455142851,2
    --85919849(+) ATTTT-/CCACAG 2 -- us2k10--------
    rs2020244601,2
    C--85919849(+) AATTTC/TCACAG 2 -- us2k10--------
    rs1473766851,2
    C--85920048(+) AGGATC/TGCTTG 2 -- us2k10--------
    rs1905191531,2
    --85920049(+) GGATCC/GCTTGA 2 -- us2k10--------
    rs1396098141,2
    --85920061(+) TCCAGG/TAGTTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for GNLY (85912298 - 85925977 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GNLY:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv4203n71CNV Loss21882294
    nsv2812CNV Loss18451855
    dgv4202n71CNV Loss21882294
    nsv874465CNV Loss21882294
    esv23053CNV Gain19812545

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 188855    OMIM disorders: --

    20/28 diseases for GNLY (see all 28):    About MalaCards
    folliculitis    spondylocostal dysostosis    inclusion body myositis    hemophagocytic lymphohistiocytosis
    stevens-johnson syndrome    toxic epidermal necrolysis    tuberculosis    measles
    subacute sclerosing panencephalitis    primary biliary cirrhosis    dysostosis    pulmonary tuberculosis
    alagille syndrome    myositis    hematopoietic stem cell transplantation    leprosy
    anaplastic large cell lymphoma    polymyositis    eclampsia    pre-eclampsia

    2 diseases from the University of Copenhagen DISEASES database for GNLY:
    Tuberculosis     Stevens-Johnson syndrome

    GNLY for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/13 Novoseek inferred disease relationships for GNLY gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberculosis 60.2 30 17445478 (2), 11574927 (2), 16301655 (2), 9756476 (2) (see all 18)
    mycobacterial infection 33.3 2 15149502 (1), 16081226 (1)
    cell damage 24.4 5 11418670 (1), 19111751 (1), 14499265 (1), 16388735 (1)
    tumors 20.6 24 19454696 (3), 17182542 (3), 15616319 (1), 15843520 (1) (see all 16)
    necrosis 6.15 4 20196946 (1), 9538144 (1), 19474732 (1)
    infectious disease 4.21 4 11175847 (2), 15294977 (1)
    measles 1.86 5 16036810 (3), 17695285 (1)
    immunodeficiency 1.19 2 17038537 (1), 19687290 (1)
    virus infection 0 1 12884856 (1)
    aids 0 1 12421959 (1)

    Genetic Association Database (GAD): GNLY
    Human Genome Epidemiology (HuGE) Navigator: GNLY (4 documents)

    Export disorders for GNLY gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNLY gene, integrated from 9 sources (see all 156):
    (articles sorted by number of sources associating them with GNLY)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cDNA clone expressed in natural killer and T cells that likely encodes a secreted protein. (PubMed id 2212946)1, 2, 3 Yabe T.... Houchins J.P. (1990)
    2. The isolation and sequence of a novel gene from a human functional T cell line. (PubMed id 2434598)1, 2, 3 Jongstra J.... Krensky A.M. (1987)
    3. Granulysin crystal structure and a structure-derived lytic mechanism. (PubMed id 12488100)1, 2, 9 Anderson D.H.... Eisenberg D. (2003)
    4. Biosynthesis of granulysin, a novel cytolytic molecule. (PubMed id 10449094)1, 2, 9 Hanson D.A.... Krensky A.M. (1999)
    5. Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells. (PubMed id 10644038)1, 2, 9 Krensky A.M. (2000)
    6. An antimicrobial activity of cytolytic T cells mediated by granulysin. (PubMed id 9756476)1, 2, 9 Stenger S.... Modlin R.L. (1998)
    7. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    8. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    9. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10578 HGNC: 4414 AceView: GNLY Ensembl:ENSG00000115523 euGenes: HUgn10578
    ECgene: GNLY H-InvDB: GNLY

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNLY Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GNLY gene:
    Search GeneIP for patents involving GNLY

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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