External Ids for GNL3L Gene
The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
GeneCards Summary for GNL3L Gene
GNL3L (Guanine Nucleotide Binding Protein-Like 3 (Nucleolar)-Like) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNL3.
UniProtKB/Swiss-Prot for GNL3L Gene
Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.