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Aliases for GNL3L Gene

Aliases for GNL3L Gene

  • G Protein Nucleolar 3 Like 2 3 5
  • Guanine Nucleotide Binding Protein-Like 3 (Nucleolar)-Like 2 3
  • G Protein Nucleolar 3B 2 3
  • Guanine Nucleotide-Binding Protein-Like 3-Like Protein 3
  • Novel GTPase 3
  • EC 3.6.1 61
  • GNL3B 3

External Ids for GNL3L Gene

Previous GeneCards Identifiers for GNL3L Gene

  • GC0XP054440
  • GC0XP051606

Summaries for GNL3L Gene

Entrez Gene Summary for GNL3L Gene

  • The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for GNL3L Gene

GNL3L (G Protein Nucleolar 3 Like) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include poly(A) RNA binding and GTPase activity. An important paralog of this gene is GNL3.

UniProtKB/Swiss-Prot for GNL3L Gene

  • Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNL3L Gene

Genomics for GNL3L Gene

Regulatory Elements for GNL3L Gene

Enhancers for GNL3L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF054481 1 Ensembl ENCODE 19.7 -46.7 -46655 3.6 CTCF KLF1 MLX TEAD4 ZMYM3 NFXL1 RAD21 ZFHX2 EGR2 ZNF263 GNL3L TSR2 FGD1 PIR39642
GH0XF054638 1.7 FANTOM5 Ensembl ENCODE 6.1 +110.4 110367 3.9 PKNOX1 ATF1 SIN3A DMAP1 ZNF2 YY1 GTF3C2 ZNF121 GLIS2 ELK1 APEX2 GNL3L PHF8 PGAM4P1 PIR60016
GH0XF054479 0.8 Ensembl ENCODE 12.3 -50.7 -50650 0.9 SMARCA4 POLR2A ZNF341 TEAD4 GNL3L FGD1 PIR39642
GH0XF054491 0.8 Ensembl ENCODE 10.2 -37.6 -37621 1.2 ZNF121 KLF1 MYC ZIC2 ZXDB ZKSCAN1 GNL3L FGD1 PIR39642
GH0XF054509 0.4 ENCODE 19.9 -20.6 -20649 1.0 ZNF121 GNL3L TSR2 FGD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GNL3L on UCSC Golden Path with GeneCards custom track

Promoters for GNL3L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000071752 290 2600 PKNOX1 ARID4B SIN3A DMAP1 BRCA1 YY1 ZNF121 ELK1 CBX5 ZNF263

Genomic Location for GNL3L Gene

Chromosome:
X
Start:
54,530,211 bp from pter
End:
54,621,565 bp from pter
Size:
91,355 bases
Orientation:
Plus strand

Genomic View for GNL3L Gene

Genes around GNL3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNL3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNL3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNL3L Gene

Proteins for GNL3L Gene

  • Protein details for GNL3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVN8-GNL3L_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein-like 3-like protein
    Protein Accession:
    Q9NVN8

    Protein attributes for GNL3L Gene

    Size:
    582 amino acids
    Molecular mass:
    65573 Da
    Quaternary structure:
    • Interacts with MDM2; this interaction, which occurs in the nucleoplasm, stabilizes MDM2. Indirectly interacts with TP53, via MDM2-binding. Interacts with TERF1; this interaction probably occurs in the nucleoplasm and is increased during mitosis, when the nucleolus is disassembled. This binding may promote TERF1 homodimerization. Interacts with TERT.

neXtProt entry for GNL3L Gene

Selected DME Specific Peptides for GNL3L Gene

Q9NVN8:
  • PNVGKSS
  • VLNKIDL

Post-translational modifications for GNL3L Gene

  • Ubiquitination at Lys 200, Lys 208, Lys 226, Lys 228, Lys 297, Lys 327, Lys 477, and Lys 482
  • Modification sites at PhosphoSitePlus

Other Protein References for GNL3L Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GNL3L Gene

Protein Domains for GNL3L Gene

Suggested Antigen Peptide Sequences for GNL3L Gene

Graphical View of Domain Structure for InterPro Entry

Q9NVN8

UniProtKB/Swiss-Prot:

GNL3L_HUMAN :
  • In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
  • Belongs to the TRAFAC class YlqF/YawG GTPase family.
Domain:
  • In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
  • Contains 1 CP-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class YlqF/YawG GTPase family.
genes like me logo Genes that share domains with GNL3L: view

No data available for Gene Families for GNL3L Gene

Function for GNL3L Gene

Molecular function for GNL3L Gene

UniProtKB/Swiss-Prot Function:
Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.

Enzyme Numbers (IUBMB) for GNL3L Gene

Gene Ontology (GO) - Molecular Function for GNL3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 16189514
GO:0005525 GTP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with GNL3L: view
genes like me logo Genes that share phenotypes with GNL3L: view

Animal Model Products

miRNA for GNL3L Gene

miRTarBase miRNAs that target GNL3L

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GNL3L Gene

Localization for GNL3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNL3L Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GNL3L gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for GNL3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA --
GO:0005697 colocalizes_with telomerase holoenzyme complex IDA 18082603
GO:0005730 nucleolus IEA,IDA 18082603
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with GNL3L: view

Pathways & Interactions for GNL3L Gene

genes like me logo Genes that share pathways with GNL3L: view

Pathways by source for GNL3L Gene

1 KEGG pathway for GNL3L Gene

Gene Ontology (GO) - Biological Process for GNL3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031397 negative regulation of protein ubiquitination IMP 19487455
GO:0031647 regulation of protein stability IMP 19487455
GO:0032091 negative regulation of protein binding IDA 19487455
GO:0032211 negative regulation of telomere maintenance via telomerase IMP 18082603
GO:0033234 negative regulation of protein sumoylation IMP 22641345
genes like me logo Genes that share ontologies with GNL3L: view

No data available for SIGNOR curated interactions for GNL3L Gene

Drugs & Compounds for GNL3L Gene

(1) Drugs for GNL3L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GNL3L: view

Transcripts for GNL3L Gene

Unigene Clusters for GNL3L Gene

Guanine nucleotide binding protein-like 3 (nucleolar)-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNL3L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: -
SP2:

Relevant External Links for GNL3L Gene

GeneLoc Exon Structure for
GNL3L
ECgene alternative splicing isoforms for
GNL3L

Expression for GNL3L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GNL3L Gene

Protein differential expression in normal tissues from HIPED for GNL3L Gene

This gene is overexpressed in Lung (56.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GNL3L Gene



Protein tissue co-expression partners for GNL3L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GNL3L Gene:

GNL3L

SOURCE GeneReport for Unigene cluster for GNL3L Gene:

Hs.654677
genes like me logo Genes that share expression patterns with GNL3L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GNL3L Gene

Orthologs for GNL3L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GNL3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNL3L 34
  • 92.46 (n)
cow
(Bos Taurus)
Mammalia GNL3L 34 35
  • 90.96 (n)
dog
(Canis familiaris)
Mammalia GNL3L 34 35
  • 90.43 (n)
rat
(Rattus norvegicus)
Mammalia Gnl3l 34
  • 87.19 (n)
mouse
(Mus musculus)
Mammalia Gnl3l 34 16 35
  • 86.9 (n)
oppossum
(Monodelphis domestica)
Mammalia GNL3L 35
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNL3L 35
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNL3L 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8285 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6058 34
zebrafish
(Danio rerio)
Actinopterygii gnl3l 35
  • 47 (a)
OneToOne
Dr.3178 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9273 34
fruit fly
(Drosophila melanogaster)
Insecta ns1 35
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nst-1 35
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NUG1 35 37
  • 25 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.2571 34
rice
(Oryza sativa)
Liliopsida Os.6742 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8939 35
  • 42 (a)
OneToMany
Species where no ortholog for GNL3L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNL3L Gene

ENSEMBL:
Gene Tree for GNL3L (if available)
TreeFam:
Gene Tree for GNL3L (if available)

Paralogs for GNL3L Gene

Paralogs for GNL3L Gene

(1) SIMAP similar genes for GNL3L Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for GNL3L Gene

genes like me logo Genes that share paralogs with GNL3L: view

Variants for GNL3L Gene

Sequence variations from dbSNP and Humsavar for GNL3L Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs111284277 -- 54,540,216(+) CCAAT(C/G/T)GAGAG reference, missense, stop-gained
rs111325753 -- 54,543,924(+) TATTT(-/G)GGGGG intron-variant
rs111905719 -- 54,540,017(+) TTGAG(A/T)GATAG intron-variant
rs112027922 -- 54,556,551(+) AGGGG(G/T)TCAGC intron-variant
rs112129915 -- 54,563,558(+) GCAGG(C/T)GGATC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GNL3L Gene

Variant ID Type Subtype PubMed ID
esv2675067 CNV deletion 23128226
esv2740175 CNV deletion 23290073
nsv1110084 CNV deletion 24896259
nsv435891 CNV deletion 17901297

Variation tolerance for GNL3L Gene

Residual Variation Intolerance Score: 45.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNL3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNL3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNL3L Gene

Disorders for GNL3L Gene

Relevant External Links for GNL3L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNL3L

No disorders were found for GNL3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNL3L Gene

Publications for GNL3L Gene

  1. GNL3L stabilizes the TRF1 complex and promotes mitotic transition. (PMID: 19487455) Zhu Q. … Tsai R.Y. (J. Cell Biol. 2009) 2 3 4 64
  2. The homologous putative GTPases Grn1p from fission yeast and the human GNL3L are required for growth and play a role in processing of nucleolar pre-rRNA. (PMID: 16251348) Du X. … Balasundaram D. (Mol. Biol. Cell 2006) 2 3 4 64
  3. A novel lysine-rich domain and GTP binding motifs regulate the nucleolar retention of human guanine nucleotide binding protein, GNL3L. (PMID: 17034816) Rao M.R.K.S. … Mahalingam S. (J. Mol. Biol. 2006) 3 4 22 64
  4. GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest. (PMID: 21132010) Meng L. … Tsai R.Y. (Oncogene 2011) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for GNL3L Gene

Sources for GNL3L Gene

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