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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GNL3L Gene

protein-coding   GIFtS: 59
GCID: GC0XP054573

Guanine Nucleotide Binding Protein-Like 3 (Nucleolar)-Like

  Search for GNL3L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Guanine Nucleotide Binding Protein-Like 3 (Nucleolar)-Like1 2
Guanine Nucleotide-Binding Protein-Like 3-Like Protein2
Novel GTPase2
EC 3.6.18

External Ids:    HGNC: 255531   Entrez Gene: 545522   Ensembl: ENSG000001301197   OMIM: 3008735   UniProtKB: Q9NVN83   

Export aliases for GNL3L gene to outside databases

Previous GC identifers: GC0XP054440 GC0XP051606


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GNL3L Gene:
The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA
processing and cell proliferation. Two transcript variants encoding the same protein have been found for this
gene. (provided by RefSeq, May 2010)

GeneCards Summary for GNL3L Gene: 
GNL3L (guanine nucleotide binding protein-like 3 (nucleolar)-like) is a protein-coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNL3.

UniProtKB/Swiss-Prot: GNL3L_HUMAN, Q9NVN8
Function: Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein
by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to
FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis,
promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence
proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal
pre-rRNA. Binds GTP




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011630.14  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNL3L gene promoter:
         USF1   HTF   USF-1:USF-2   CREB   PPAR-gamma1   deltaCREB   FOXJ2 (long isoform)   USF-1   PPAR-gamma2   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGNL3L promoter sequence
   Search SABiosciences Chromatin IP Primers for GNL3L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GNL3L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.22

GNL3L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNL3L gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP054573:  view genomic region     (about GC identifiers)

Start:
54,556,644 bp from pter      End:
54,593,720 bp from pter
Size:
37,077 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GNL3L_HUMAN, Q9NVN8 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein-like 3-like protein  
Size: 582 amino acids; 65573 Da
Subunit: Interacts with MDM2; this interaction, which occurs in the nucleoplasm, stabilizes MDM2. Indirectly
interacts with TP53, via MDM2-binding. Interacts with TERF1; this interaction probably occurs in the nucleoplasm
and is increased during mitosis, when the nucleolus is disassembled. This binding may promote TERF1
homodimerization. Interacts with TERT
Subcellular location: Nucleus, nucleolus
Developmental stage: Up-regulated during mitosis and down-regulated in the G1 phase

Explore the universe of human proteins at neXtProt for GNL3L: NX_Q9NVN8

Explore proteomics data for GNL3L at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NVN8

  • 2 DME Specific Peptides for GNL3L (Q9NVN8)
     PNVGKSS  VLNKIDL 

    GNL3L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GNL3L Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001171748.1  NP_061940.1  

    ENSEMBL proteins: 
     ENSP00000338573   ENSP00000354091  

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    Cloud-Clone Corp. Proteins for GNL3L 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0016021integral to membrane ----

    GNL3L for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR006073 GTP_binding_domain

    Graphical View of Domain Structure for InterPro Entry Q9NVN8

    ProtoNet protein and cluster: Q9NVN8

    1 Blocks protein domain: IPB002917 GTP-binding protein

    UniProtKB/Swiss-Prot: GNL3L_HUMAN, Q9NVN8
    Domain: In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the
    GTPase motifs described by a G4-G1-G3 pattern
    Similarity: Belongs to the MMR1/HSR1 GTP-binding protein family
    Similarity: Contains 1 G (guanine nucleotide-binding) domain


    GNL3L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GNL3L_HUMAN, Q9NVN8
    Function: Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein
    by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to
    FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis,
    promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence
    proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal
    pre-rRNA. Binds GTP

         Enzyme Number (IUBMB): EC 3.6.12

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IBA--
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IEA--
    GO:0015093ferrous iron transmembrane transporter activity ----
         
    GNL3L for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for GNL3L:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Synthetic lethal with Ras  Wnt reporter downregulated 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GNL3L About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for GNL3L):
        Ribosome biogenesis in eukaryotes


    GNL3L for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GNL3L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/36 Interacting proteins for GNL3L (Q9NVN81, 2, 3 ENSP000003385734) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009871, 3, ENSP000004172814EBI-746682,EBI-389668 I2D: score=1 STRING: ENSP00000417281
    LDOC1O957512, 3, ENSP000003595574MINT-66887 I2D: score=5 STRING: ENSP00000359557
    TERF1P542743, ENSP000002766034I2D: score=1 STRING: ENSP00000276603
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    TERTO147463, ENSP000003095724I2D: score=1 STRING: ENSP00000309572
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IBA--
    GO:0015684ferrous iron transport ----
    GO:0042254ribosome biogenesis IBA--

    GNL3L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    1 HMDB Compound for GNL3L    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about GNL3L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for GNL3L gene (2 alternative transcripts): 
    NM_001184819.1  NM_019067.5  

    Unigene Cluster for GNL3L:

    Guanine nucleotide binding protein-like 3 (nucleolar)-like
    Hs.654677  [show with all ESTs]
    Unigene Representative Sequence: NM_001184819
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336470(uc022bxi.1 uc004dth.2) ENST00000360845(uc004dti.3)
    ENST00000489691
    miRNA
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    Additional mRNA sequence: 

    AK001475.1 AK022325.1 AK128277.1 BC003603.1 BC022829.1 

    18 DOTS entries:

    DT.92453428  DT.86852238  DT.100764592  DT.91730763  DT.100676922  DT.95362871  DT.100716565  DT.100764590 
    DT.97836315  DT.102829668  DT.121631359  DT.100751811  DT.100764588  DT.91831606  DT.95153303  DT.92053609 
    DT.95072412  DT.95248066 

    24/228 AceView cDNA sequences (see all 228):

    AL705540 BQ054441 BI870401 AW246605 BE313469 BE162710 BF897048 BQ070565 
    F02263 BE904986 BP870864 AW002656 AA767580 BQ892933 BF811026 BQ641560 
    AI870837 BE300886 AI686619 BQ674906 AI468754 CB116341 AW978438 BG824602 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for GNL3L    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
    SP1:        -                                                                                                   
    SP2:                                                                                                            


    ECgene alternative splicing isoforms for GNL3L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GNL3L expression in normal human tissues (normalized intensities)      GNL3L embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GNL3L Expression
    About this image


    GNL3L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
             heart muscle ; myocytes   

    See GNL3L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GNL3L

    SOURCE GeneReport for Unigene cluster: Hs.654677
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GNL3L gene from 9/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gnl3l1 , 5 guanine nucleotide binding protein-like 3 (nucleolar)-like1, 5 86.9(n)1
    88.17(a)1
      X (68.46 cM)5
    2371071  NM_001168600.11  NP_001162071.11 
     1509831415 
    lizard
    (Anolis carolinensis)
    Reptilia GNL3L6
    guanine nucleotide binding protein-like 3 (nucleol...
    50(a)
    1 ↔ 1
    1(205178454-205206001)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.60582 Xenopus laevis transcribed sequence with weak similarity more 74.95(n)    BJ038338.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.31782 Transcribed sequence with weak similarity to protein more 74.67(n)    CA787345.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ns11 nucleostemin 1 49.43(n)
    43.76(a)
      42060  NM_169742.2  NP_732199.2 
    worm
    (Caenorhabditis elegans)
    Secernentea nst-11 Protein NST-1 49.87(n)
    42.14(a)
      174329  NM_063348.2  NP_495749.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NUG1(YER006W)4
    NUG11
    GTPase that associates with nuclear 60S pre-ribosomes, more4
    Nug1p1
    46.28(n)1
    42.12(a)1
      5(162723-164285)4
    8567231, 4  NP_010921.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G070501 putative GTP-binding protein 50.04(n)
    43.36(a)
      819890  NM_111585.4  NP_187361.1 
    rice
    (Oryza sativa)
    Liliopsida Os.67422 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.22(n)    AK103410.1 


    ENSEMBL Gene Tree for GNL3L (if available)
    TreeFam Gene Tree for GNL3L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GNL3L gene
    GNL32  
    1 SIMAP similar gene for GNL3L using alignment to 2 protein entries:     GNL3L_HUMAN (see all proteins):
    GNL3

    GNL3L for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GNL3L
    PGOHUM00000235235


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/537 SNPs in GNL3L are shown (see all 537)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1389464461,2
    --51604468(+) AAAAAA/TAATTA 2 -- us2k10--------
    rs120129781,2
    C,H--51604507(+) caacaC/Ttgttt 2 -- us2k14Minor allele frequency- T:0.14WA NA 7
    rs1851978351,2
    --54569065(+) TTTGAA/TATTTA 2 -- us2k10--------
    rs1899065821,2
    --54569101(+) TCATTC/TTTTTT 2 -- us2k10--------
    rs1819301371,2
    --54569312(+) ATCTAC/TCTACC 2 -- us2k10--------
    rs1145089191,2
    C--54569393(+) CTAATG/TGTTTT 2 -- us2k10--------
    rs1873802321,2
    --54569668(+) TGTGGG/TGCAGG 2 -- us2k10--------
    rs1920997121,2
    --54569690(+) ACCCAC/TTTAAC 2 -- us2k10--------
    rs1836024091,2
    --54569847(+) TTAGCA/TGTATA 2 -- us2k10--------
    rs1397233931,2
    C--54569865(+) TGCTCC/TGGGTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for GNL3L (54556644 - 54593720 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GNL3L:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2740175CNV Deletion23290073
    esv2675067CNV Deletion23128226
    nsv435891CNV Deletion17901297


    Locus Specific Mutation Databases (LSDB): GNL3L
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GNL3L
    DNA2.0 Custom Variant and Variant Library Synthesis for GNL3L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GNL3L for disorders           About MalaCards
    OMIM gene information: 300873    OMIM disorders: --


    GNL3L for disorders           About GeneDecksing


    Export disorders for GNL3L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GNL3L gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with GNL3L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel lysine-rich domain and GTP binding motifs regulate the nucleolar retention of human guanine nucleotide binding protein, GNL3L. (PubMed id 17034816)1, 2, 9 Rao M.R.K.S....Mahalingam S. (2006)
    2. GNL3L depletion destabilizes MDM2 and induces p53-dep endent G2/M arrest. (PubMed id 21132010)1, 2 Meng L....Tsai R.Y. (2011)
    3. GNL3L stabilizes the TRF1 complex and promotes mitoti c transition. (PubMed id 19487455)1, 2 Zhu Q....Tsai R.Y. (2009)
    4. The homologous putative GTPases Grn1p from fission yeast and the human GNL3L are required for growth and play a role in processing of nucleolar pre-rRNA. (PubMed id 16251348)1, 2 Du X.... Balasundaram D. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    7. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54552 HGNC: 25553 AceView: FLJ10613 Ensembl:ENSG00000130119 euGenes: HUgn54552
    ECgene: GNL3L Kegg: 54552 H-InvDB: GNL3L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GNL3L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GNL3L gene:
    Search GeneIP for patents involving GNL3L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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