Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GNL3L Gene

Aliases for GNL3L Gene

  • Guanine Nucleotide Binding Protein-Like 3 (Nucleolar)-Like 2 3
  • EC 3.6.1 63

External Ids for GNL3L Gene

Previous GeneCards Identifiers for GNL3L Gene

  • GC0XP054440
  • GC0XP051606

Summaries for GNL3L Gene

Entrez Gene Summary for GNL3L Gene

  • The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for GNL3L Gene

GNL3L (Guanine Nucleotide Binding Protein-Like 3 (Nucleolar)-Like) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNL3.

UniProtKB/Swiss-Prot for GNL3L Gene

  • Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNL3L Gene

Genomics for GNL3L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GNL3L Gene

Start:
54,530,211 bp from pter
End:
54,567,287 bp from pter
Size:
37,077 bases
Orientation:
Plus strand

Genomic View for GNL3L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNL3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNL3L Gene

Proteins for GNL3L Gene

  • Protein details for GNL3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVN8-GNL3L_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein-like 3-like protein
    Protein Accession:
    Q9NVN8
    Secondary Accessions:

    Protein attributes for GNL3L Gene

    Size:
    582 amino acids
    Molecular mass:
    65573 Da
    Quaternary structure:
    • Interacts with MDM2; this interaction, which occurs in the nucleoplasm, stabilizes MDM2. Indirectly interacts with TP53, via MDM2-binding. Interacts with TERF1; this interaction probably occurs in the nucleoplasm and is increased during mitosis, when the nucleolus is disassembled. This binding may promote TERF1 homodimerization. Interacts with TERT.

neXtProt entry for GNL3L Gene

Proteomics data for GNL3L Gene at MOPED

Selected DME Specific Peptides for GNL3L Gene

Post-translational modifications for GNL3L Gene

  • Ubiquitination at Lys200, Lys208, Lys226, Lys228, Lys297, Lys327, Lys477, and Lys482
  • Modification sites at PhosphoSitePlus

Other Protein References for GNL3L Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for GNL3L Gene

Protein Domains for GNL3L Gene

Suggested Antigen Peptide Sequences for GNL3L Gene

Graphical View of Domain Structure for InterPro Entry

Q9NVN8

UniProtKB/Swiss-Prot:

GNL3L_HUMAN :
  • Q9NVN8
Domain:
  • In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern
  • Contains 1 CP-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class YlqF/YawG GTPase family.
genes like me logo Genes that share domains with GNL3L: view

No data available for Gene Families for GNL3L Gene

Function for GNL3L Gene

Molecular function for GNL3L Gene

UniProtKB/Swiss-Prot Function: Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.

Enzyme Numbers (IUBMB) for GNL3L Gene

Gene Ontology (GO) - Molecular Function for GNL3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 21132010
GO:0005525 GTP binding IEA --
GO:0015093 ferrous iron transmembrane transporter activity --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with GNL3L: view
genes like me logo Genes that share phenotypes with GNL3L: view

Animal Model Products

CRISPR Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for GNL3L Gene

Localization for GNL3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNL3L Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNL3L Gene COMPARTMENTS Subcellular localization image for GNL3L gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 2

Gene Ontology (GO) - Cellular Components for GNL3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with GNL3L: view

Pathways for GNL3L Gene

genes like me logo Genes that share pathways with GNL3L: view

Pathways by source for GNL3L Gene

1 KEGG pathway for GNL3L Gene

Gene Ontology (GO) - Biological Process for GNL3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0008152 metabolic process IBA --
GO:0015684 ferrous iron transport --
GO:0042254 ribosome biogenesis IBA --
genes like me logo Genes that share ontologies with GNL3L: view

Compounds for GNL3L Gene

(1) HMDB Compounds for GNL3L Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with GNL3L: view

Transcripts for GNL3L Gene

Unigene Clusters for GNL3L Gene

Guanine nucleotide binding protein-like 3 (nucleolar)-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNL3L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNL3L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: -
SP2:

Relevant External Links for GNL3L Gene

GeneLoc Exon Structure for
GNL3L
ECgene alternative splicing isoforms for
GNL3L

Expression for GNL3L Gene

mRNA expression in normal human tissues for GNL3L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNL3L Gene

SOURCE GeneReport for Unigene cluster for GNL3L Gene Hs.654677

genes like me logo Genes that share expressions with GNL3L: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GNL3L Gene

Orthologs for GNL3L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GNL3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNL3L 35
  • 92.46 (n)
  • 91.93 (a)
cow
(Bos Taurus)
Mammalia GNL3L 35
  • 90.96 (n)
  • 92.7 (a)
GNL3L 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNL3L 35
  • 90.43 (n)
  • 91.65 (a)
GNL3L 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gnl3l 35
  • 86.9 (n)
  • 88.17 (a)
Gnl3l 16
Gnl3l 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNL3L 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNL3L 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gnl3l 35
  • 87.19 (n)
  • 89.22 (a)
lizard
(Anolis carolinensis)
Reptilia GNL3L 36
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6058 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8285 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9273 35
zebrafish
(Danio rerio)
Actinopterygii Dr.3178 35
gnl3l 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ns1 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nst-1 36
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NUG1 36
  • 25 (a)
OneToMany
NUG1 38
barley
(Hordeum vulgare)
Liliopsida Hv.2571 35
rice
(Oryza sativa)
Liliopsida Os.6742 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8939 36
  • 42 (a)
OneToMany
Species with no ortholog for GNL3L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNL3L Gene

ENSEMBL:
Gene Tree for GNL3L (if available)
TreeFam:
Gene Tree for GNL3L (if available)

Paralogs for GNL3L Gene

Paralogs for GNL3L Gene

Selected SIMAP similar genes for GNL3L Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for GNL3L Gene

genes like me logo Genes that share paralogs with GNL3L: view

Variants for GNL3L Gene

Sequence variations from dbSNP and Humsavar for GNL3L Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1128486 -- 54,566,913(+) ggacc(A/G)caggc utr-variant-3-prime
rs1137144 -- 54,563,515(+) acgat(A/G)gctct utr-variant-3-prime
rs1137145 -- 54,563,529(+) ctgta(A/G)tccca utr-variant-3-prime
rs1137147 -- 54,563,564(+) ggatc(A/G)cttga utr-variant-3-prime
rs1137148 -- 54,563,613(+) acctc(A/G)tctct utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GNL3L Gene

Variant ID Type Subtype PubMed ID
nsv435891 CNV Deletion 17901297
esv2740175 CNV Deletion 23290073
esv2675067 CNV Deletion 23128226

Relevant External Links for GNL3L Gene

HapMap Linkage Disequilibrium report
GNL3L
Locus Specific Mutation Databases (LSDB)
GNL3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNL3L Gene

Disorders for GNL3L Gene

No disorders were found for GNL3L Gene.

No data available for UniProtKB/Swiss-Prot for GNL3L Gene

Publications for GNL3L Gene

  1. A novel lysine-rich domain and GTP binding motifs regulate the nucleolar retention of human guanine nucleotide binding protein, GNL3L. (PMID: 17034816) Rao M.R.K.S. … Mahalingam S. (J. Mol. Biol. 2006) 3 4 23
  2. The homologous putative GTPases Grn1p from fission yeast and the human GNL3L are required for growth and play a role in processing of nucleolar pre-rRNA. (PMID: 16251348) Du X. … Balasundaram D. (Mol. Biol. Cell 2006) 2 3 4
  3. GNL3L stabilizes the TRF1 complex and promotes mitotic transition. (PMID: 19487455) Zhu Q. … Tsai R.Y. (J. Cell Biol. 2009) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest. (PMID: 21132010) Meng L. … Tsai R.Y. (Oncogene 2011) 3 4

Products for GNL3L Gene

Sources for GNL3L Gene

Back to Top

Content