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Aliases for GNL3 Gene

Aliases for GNL3 Gene

  • Guanine Nucleotide Binding Protein-Like 3 (Nucleolar) 2 3
  • Nucleostemin 2 3 4
  • Nucleolar GTP-Binding Protein 3 3 4
  • Novel Nucleolar Protein 47 3 4
  • E2-Induced Gene 3 Protein 3 4
  • E2IG3 3 4
  • NNP47 3 4
  • NS 3 4
  • Estradiol-Induced Nucleotide Binding Protein 3
  • C77032 3

External Ids for GNL3 Gene

Previous GeneCards Identifiers for GNL3 Gene

  • GC03P052695
  • GC03P052718

Summaries for GNL3 Gene

Entrez Gene Summary for GNL3 Gene

  • The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for GNL3 Gene

GNL3 (Guanine Nucleotide Binding Protein-Like 3 (Nucleolar)) is a Protein Coding gene. Diseases associated with GNL3 include noonan syndrome 3 and cardiofaciocutaneous syndrome 2. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include poly(A) RNA binding and GTPase activity. An important paralog of this gene is GNL3L.

UniProtKB/Swiss-Prot for GNL3 Gene

  • May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).

Gene Wiki entry for GNL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNL3 Gene

Genomics for GNL3 Gene

Regulatory Elements for GNL3 Gene

Genomic Location for GNL3 Gene

Chromosome:
3
Start:
52,681,156 bp from pter
End:
52,694,497 bp from pter
Size:
13,342 bases
Orientation:
Plus strand

Genomic View for GNL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNL3 Gene

Proteins for GNL3 Gene

  • Protein details for GNL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVP2-GNL3_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein-like 3
    Protein Accession:
    Q9BVP2
    Secondary Accessions:
    • B2RDC1
    • Q5PU80
    • Q96SV6
    • Q96SV7
    • Q9UJY0

    Protein attributes for GNL3 Gene

    Size:
    549 amino acids
    Molecular mass:
    61993 Da
    Quaternary structure:
    • Interacts with MDM2; this interaction stabilizes MDM2. Interaction with MDM2 occurs in the nucleoplasm and is triggered by a nucleolar release mechanism, such as mitosis-induced nucleolar disassembly (By similarity). Indirectly interacts with TP53, via MDM2-binding (By similarity).
    SequenceCaution:
    • Sequence=AAF09482.1; Type=Frameshift; Positions=516; Evidence={ECO:0000305};

    Alternative splice isoforms for GNL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GNL3 Gene

Proteomics data for GNL3 Gene at MOPED

Post-translational modifications for GNL3 Gene

  • Ubiquitination at Lys 253
  • Modification sites at PhosphoSitePlus

Other Protein References for GNL3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GNL3 (GNL3)

No data available for DME Specific Peptides for GNL3 Gene

Domains & Families for GNL3 Gene

Protein Domains for GNL3 Gene

Suggested Antigen Peptide Sequences for GNL3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BVP2

UniProtKB/Swiss-Prot:

GNL3_HUMAN :
  • The basic domain (B) allows nucleolar localization in the absence of GTP. The intermediate domain (I) inhibits nucleolar localization by the B domain and is required for exit from the nucleolus. Exit from the nucleolus to the nucleoplasm requires both the I and the acidic (A) domains, and may be triggered by GTP hydrolysis (By similarity).
  • Belongs to the TRAFAC class YlqF/YawG GTPase family.
Domain:
  • The basic domain (B) allows nucleolar localization in the absence of GTP. The intermediate domain (I) inhibits nucleolar localization by the B domain and is required for exit from the nucleolus. Exit from the nucleolus to the nucleoplasm requires both the I and the acidic (A) domains, and may be triggered by GTP hydrolysis (By similarity).
  • In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern
  • Contains 1 CP-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class YlqF/YawG GTPase family.
genes like me logo Genes that share domains with GNL3: view

No data available for Gene Families for GNL3 Gene

Function for GNL3 Gene

Molecular function for GNL3 Gene

UniProtKB/Swiss-Prot Function:
May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).

Gene Ontology (GO) - Molecular Function for GNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 16097049
GO:0005525 GTP binding ISS --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with GNL3: view
genes like me logo Genes that share phenotypes with GNL3: view

Animal Models for GNL3 Gene

MGI Knock Outs for GNL3:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNL3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GNL3 Gene

Localization for GNL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNL3 Gene

Nucleus. Nucleus, nucleolus. Note=Shuttles between the nucleus and nucleolus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNL3 Gene COMPARTMENTS Subcellular localization image for GNL3 gene
Compartment Confidence
extracellular 5
nucleus 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for GNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IEA --
GO:0005730 nucleolus ISS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with GNL3: view

Pathways & Interactions for GNL3 Gene

genes like me logo Genes that share pathways with GNL3: view

Pathways by source for GNL3 Gene

1 KEGG pathway for GNL3 Gene

Gene Ontology (GO) - Biological Process for GNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation IEA --
GO:0042127 regulation of cell proliferation ISS --
GO:0042254 ribosome biogenesis IBA --
GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter IMP 25569094
genes like me logo Genes that share ontologies with GNL3: view

No data available for SIGNOR curated interactions for GNL3 Gene

Drugs & Compounds for GNL3 Gene

(1) Drugs for GNL3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GNL3: view

Transcripts for GNL3 Gene

Unigene Clusters for GNL3 Gene

Guanine nucleotide binding protein-like 3 (nucleolar):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNL3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNL3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - - - -
SP9: - - - -
SP10: - - - -
SP11: - -
SP12: -
SP13: - -
SP14:
SP15:
SP16:
SP17:

ExUns: 12d ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for GNL3 Gene

GeneLoc Exon Structure for
GNL3
ECgene alternative splicing isoforms for
GNL3

Expression for GNL3 Gene

mRNA expression in normal human tissues for GNL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GNL3 Gene

This gene is overexpressed in Lung (49.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNL3 Gene



SOURCE GeneReport for Unigene cluster for GNL3 Gene Hs.313544

mRNA Expression by UniProt/SwissProt for GNL3 Gene

Q9BVP2-GNL3_HUMAN
Tissue specificity: Increased levels in lung tissue in cancer patients.
genes like me logo Genes that share expression patterns with GNL3: view

Protein tissue co-expression partners for GNL3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for GNL3 Gene

Orthologs for GNL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GNL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GNL3 35
  • 85.63 (n)
  • 78.53 (a)
GNL3 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNL3 35
  • 83.33 (n)
  • 80.04 (a)
GNL3 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gnl3 35
  • 79.86 (n)
  • 73.61 (a)
Gnl3 16
Gnl3 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GNL3 35
  • 99.51 (n)
  • 99.27 (a)
GNL3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gnl3 35
  • 81.41 (n)
  • 76.21 (a)
oppossum
(Monodelphis domestica)
Mammalia GNL3 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNL3 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves GNL3 35
  • 59.42 (n)
  • 56.9 (a)
GNL3 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNL3 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gnl3 35
  • 54.89 (n)
  • 48.04 (a)
zebrafish
(Danio rerio)
Actinopterygii gnl3 35
  • 53.11 (n)
  • 46.58 (a)
wufc55d07 35
gnl3 36
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ns1 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nst-1 36
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NUG1 36
  • 28 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4890 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8939 36
  • 38 (a)
OneToMany
Species with no ortholog for GNL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GNL3 Gene

ENSEMBL:
Gene Tree for GNL3 (if available)
TreeFam:
Gene Tree for GNL3 (if available)

Paralogs for GNL3 Gene

Paralogs for GNL3 Gene

(1) SIMAP similar genes for GNL3 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for GNL3 Gene

genes like me logo Genes that share paralogs with GNL3: view

Variants for GNL3 Gene

Sequence variations from dbSNP and Humsavar for GNL3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1344932 -- 52,693,495(-) AAGCC(A/G)CTTTT reference, synonymous-codon
rs4532127 -- 52,693,720(+) CATGA(A/G)GAATT reference, synonymous-codon
rs34216132 -- 52,693,659(+) CAATA(C/G)CATCC missense, reference
rs79807717 -- 52,693,791(+) AACTG(C/G/T)TGATG missense, reference
rs80333749 -- 52,693,740(+) GAAAG(A/G)AAGGA reference, missense

Variation tolerance for GNL3 Gene

Residual Variation Intolerance Score: 63.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.46; 97.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNL3 Gene

HapMap Linkage Disequilibrium report
GNL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GNL3 Gene

Disorders for GNL3 Gene

MalaCards: The human disease database

(10) MalaCards diseases for GNL3 Gene - From: OMIM and DISEASES

Disorder Aliases PubMed IDs
noonan syndrome 3
  • kras gene related noonan syndrome
cardiofaciocutaneous syndrome 2
  • cfc2
ras-associated autoimmune leukoproliferative disorder
  • autoimmune lymphoproliferative syndrome type iv
schimmelpenning-feuerstein-mims syndrome, somatic mosaic
  • ss
gastric cancer risk after h. pylori infection
  • gastric cancer, somatic
- elite association
Search GNL3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GNL3

Genetic Association Database (GAD)
GNL3
Human Genome Epidemiology (HuGE) Navigator
GNL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNL3
genes like me logo Genes that share disorders with GNL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GNL3 Gene

Publications for GNL3 Gene

  1. A nucleolar mechanism controlling cell proliferation in stem and cancer cells. (PMID: 12464630) Tsai R.Y.L. … McKay R.D.G. (Genes Dev. 2002) 2 23 67
  2. Expression of nucleostemin, epidermal growth factor and epidermal growth factor receptor in human esophageal squamous cell carcinoma tissues. (PMID: 19823871) Zhang G. … Wu W. (J. Cancer Res. Clin. Oncol. 2010) 23 67
  3. Biologic characteristics of the side population of human small cell lung cancer cell line H446. (PMID: 20193106) Wang B. … Zhang J.N. (Chin J Cancer 2010) 23 67
  4. Post-mitotic role of nucleostemin as a promoter of skeletal muscle cell differentiation. (PMID: 19914205) Hirai H. … Kikyo N. (Biochem. Biophys. Res. Commun. 2010) 23 67
  5. Lentivirus-modified human umbilical cord mesenchymal stem cells maintain their pluripotency. (PMID: 19961436) Qian H. … Sun J. (Biotechnol. Appl. Biochem. 2010) 23 67

Products for GNL3 Gene

Sources for GNL3 Gene

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