Aliases for GNL3 Gene
External Ids for GNL3 Gene
Previous GeneCards Identifiers for GNL3 Gene
The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
GeneCards Summary for GNL3 Gene
GNL3 (Guanine Nucleotide Binding Protein-Like 3 (Nucleolar)) is a Protein Coding gene. Diseases associated with GNL3 include noonan syndrome 3 and cardiofaciocutaneous syndrome 2. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include poly(A) RNA binding and GTPase activity. An important paralog of this gene is GNL3L.
UniProtKB/Swiss-Prot for GNL3 Gene
May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).