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Aliases for GNL2 Gene

Aliases for GNL2 Gene

  • Guanine Nucleotide Binding Protein-Like 2 (Nucleolar) 2 3
  • Autoantigen NGP-1 3 4
  • Nucleostemin-2 2 3
  • NGP1 3 4
  • Novel Nucleolar Guanosine 5-Triphosphate Binding Protein Autoantigen 3
  • Nucleolar G-Protein Gene 1 3
  • Nucleolar GTPase 3
  • HUMAUANTIG 3
  • Ngp-1 3
  • Nog2 3
  • Nug2 3

External Ids for GNL2 Gene

Previous GeneCards Identifiers for GNL2 Gene

  • GC01M037701
  • GC01M037805
  • GC01M038032
  • GC01M036149

Summaries for GNL2 Gene

GeneCards Summary for GNL2 Gene

GNL2 (Guanine Nucleotide Binding Protein-Like 2 (Nucleolar)) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include poly(A) RNA binding and GTPase activity.

UniProtKB/Swiss-Prot for GNL2 Gene

  • GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.

Gene Wiki entry for GNL2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNL2 Gene

Genomics for GNL2 Gene

Regulatory Elements for GNL2 Gene

Genomic Location for GNL2 Gene

Chromosome:
1
Start:
37,566,812 bp from pter
End:
37,595,985 bp from pter
Size:
29,174 bases
Orientation:
Minus strand

Genomic View for GNL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNL2 Gene

Proteins for GNL2 Gene

  • Protein details for GNL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13823-NOG2_HUMAN
    Recommended name:
    Nucleolar GTP-binding protein 2
    Protein Accession:
    Q13823
    Secondary Accessions:
    • Q9BWN7

    Protein attributes for GNL2 Gene

    Size:
    731 amino acids
    Molecular mass:
    83655 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GNL2 Gene

Proteomics data for GNL2 Gene at MOPED

Post-translational modifications for GNL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GNL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNL2 Gene

Domains & Families for GNL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q13823

UniProtKB/Swiss-Prot:

NOG2_HUMAN :
  • Contains 1 CP-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
Domain:
  • Contains 1 CP-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
genes like me logo Genes that share domains with GNL2: view

No data available for Gene Families for GNL2 Gene

Function for GNL2 Gene

Molecular function for GNL2 Gene

UniProtKB/Swiss-Prot Function:
GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.

Gene Ontology (GO) - Molecular Function for GNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 8822211
GO:0005525 GTP binding NAS 8822211
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with GNL2: view
genes like me logo Genes that share phenotypes with GNL2: view

Animal Model Products

miRNA for GNL2 Gene

miRTarBase miRNAs that target GNL2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GNL2 Gene

Localization for GNL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNL2 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNL2 Gene COMPARTMENTS Subcellular localization image for GNL2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for GNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8822211
GO:0005730 nucleolus IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with GNL2: view

Pathways & Interactions for GNL2 Gene

genes like me logo Genes that share pathways with GNL2: view

Pathways by source for GNL2 Gene

1 KEGG pathway for GNL2 Gene

Gene Ontology (GO) - Biological Process for GNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0042254 ribosome biogenesis IBA --
genes like me logo Genes that share ontologies with GNL2: view

No data available for SIGNOR curated interactions for GNL2 Gene

Drugs & Compounds for GNL2 Gene

(1) Drugs for GNL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GNL2: view

Transcripts for GNL2 Gene

Unigene Clusters for GNL2 Gene

Guanine nucleotide binding protein-like 2 (nucleolar):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNL2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: - - - -
SP8: -
SP9:
SP10:
SP11:
SP12: - -
SP13: -
SP14:
SP15:

ExUns: 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for GNL2 Gene

GeneLoc Exon Structure for
GNL2
ECgene alternative splicing isoforms for
GNL2

Expression for GNL2 Gene

mRNA expression in normal human tissues for GNL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GNL2 Gene

This gene is overexpressed in Lung (58.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNL2 Gene



SOURCE GeneReport for Unigene cluster for GNL2 Gene Hs.75528

mRNA Expression by UniProt/SwissProt for GNL2 Gene

Q13823-NOG2_HUMAN
Tissue specificity: Ubiquitously expressed at relatively low levels in all human tissues tested, with the highest level of expression in the testes
genes like me logo Genes that share expression patterns with GNL2: view

Protein tissue co-expression partners for GNL2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for GNL2 Gene

Orthologs for GNL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GNL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GNL2 35
  • 87.19 (n)
  • 88.16 (a)
GNL2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNL2 35
  • 88.45 (n)
  • 88.41 (a)
GNL2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gnl2 35
  • 84.57 (n)
  • 85.71 (a)
Gnl2 16
Gnl2 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GNL2 35
  • 99.77 (n)
  • 99.45 (a)
GNL2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gnl2 35
  • 83.65 (n)
  • 84.62 (a)
oppossum
(Monodelphis domestica)
Mammalia GNL2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNL2 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves GNL2 35
  • 73.68 (n)
  • 77.01 (a)
GNL2 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNL2 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gnl2 35
  • 69.16 (n)
  • 75.4 (a)
Str.15036 35
African clawed frog
(Xenopus laevis)
Amphibia 1i973-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16124 35
LOC100536859 35
  • 66.43 (n)
  • 70.06 (a)
gnl2 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011309 35
  • 54.58 (n)
  • 54.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta ns2 35
  • 54.29 (n)
  • 53.37 (a)
ns2 36
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ngp-1 35
  • 56.65 (n)
  • 55.23 (a)
ngp-1 36
  • 45 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR120C 35
  • 55.94 (n)
  • 55.36 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C18843g 35
  • 54.97 (n)
  • 56.12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOG2 35
  • 57.62 (n)
  • 57.7 (a)
NOG2 36
  • 53 (a)
OneToOne
NOG2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G52980 35
  • 57.31 (n)
  • 53.85 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7772 35
barley
(Hordeum vulgare)
Liliopsida Hv.3131 35
rice
(Oryza sativa)
Liliopsida Os.26043 35
Os03g0352400 35
  • 57.27 (n)
  • 54.2 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2915 35
corn
(Zea mays)
Liliopsida Zm.6589 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02546 35
  • 55.81 (n)
  • 54.5 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC6F6.03c 35
  • 55.21 (n)
  • 51.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for GNL2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for GNL2 Gene

ENSEMBL:
Gene Tree for GNL2 (if available)
TreeFam:
Gene Tree for GNL2 (if available)

Paralogs for GNL2 Gene

Pseudogenes.org Pseudogenes for GNL2 Gene

genes like me logo Genes that share paralogs with GNL2: view

No data available for Paralogs for GNL2 Gene

Variants for GNL2 Gene

Sequence variations from dbSNP and Humsavar for GNL2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs215201 -- 37,569,495(+) TAGGA(C/T)CAAAG intron-variant
rs215202 -- 37,572,632(+) tcccc(A/C)atacc intron-variant
rs2076519 -- 37,567,446(+) GAGGA(G/T)AGTCC intron-variant
rs2294875 -- 37,586,844(+) ACCAA(C/T)GTCTC intron-variant
rs2360010 -- 37,581,319(+) AAATA(G/T)ACAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNL2 Gene

Variant ID Type Subtype PubMed ID
nsv483134 CNV Loss 15286789
nsv524834 CNV Gain 19592680
nsv834746 CNV Loss 17160897

Variation tolerance for GNL2 Gene

Residual Variation Intolerance Score: 21.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GNL2 Gene

HapMap Linkage Disequilibrium report
GNL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNL2 Gene

Disorders for GNL2 Gene

Relevant External Links for GNL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GNL2
genes like me logo Genes that share disorders with GNL2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNL2 Gene

Publications for GNL2 Gene

  1. Coupled GTPase and remodelling ATPase activities form a checkpoint for ribosome export. (PMID: 24240281) Matsuo Y. … Hurt E. (Nature 2014) 2 67
  2. Nucleolar trafficking of nucleostemin family proteins: common versus protein-specific mechanisms. (PMID: 17923687) Meng L. … Tsai R.Y. (Mol. Cell. Biol. 2007) 23 67
  3. Cloning of a novel nucleolar guanosine 5'-triphosphate binding protein autoantigen from a breast tumor. (PMID: 8822211) Racevskis J. … Fineberg S.A. (Cell Growth Differ. 1996) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67

Products for GNL2 Gene

Sources for GNL2 Gene

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