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Aliases for GNL1 Gene

Aliases for GNL1 Gene

  • G Protein Nucleolar 1 (Putative) 2 3
  • Guanine Nucleotide Binding Protein-Like 1 2 3 5
  • GTP-Binding Protein HSR1 3 4
  • HSR1 3 4
  • HSR1 GTP-Binding Protein 3

External Ids for GNL1 Gene

Previous GeneCards Identifiers for GNL1 Gene

  • GC06M030569
  • GC06M030284
  • GC06M030619
  • GC06M030621
  • GC06M030509

Summaries for GNL1 Gene

Entrez Gene Summary for GNL1 Gene

  • The GNL1 gene, identified in the human major histocompatibility complex class I region, shows a high degree of similarity with its mouse counterpart. The GNL1 gene is located less than 2 kb centromeric to HLA-E, in the same transcriptional orientation. GNL1 is telomeric to HLA-B and HLA-C. [provided by RefSeq, Jul 2008]

GeneCards Summary for GNL1 Gene

GNL1 (G Protein Nucleolar 1 (Putative)) is a Protein Coding gene. GO annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is LSG1.

UniProtKB/Swiss-Prot for GNL1 Gene

  • Possible regulatory or functional link with the histocompatibility cluster.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNL1 Gene

Genomics for GNL1 Gene

Regulatory Elements for GNL1 Gene

Enhancers for GNL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GNL1 on UCSC Golden Path with GeneCards custom track

Promoters for GNL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GNL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GNL1 Gene

30,541,377 bp from pter
30,557,594 bp from pter
16,218 bases
Minus strand

Genomic View for GNL1 Gene

Genes around GNL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for GNL1 Gene

  • Protein details for GNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Guanine nucleotide-binding protein-like 1
    Protein Accession:
    Secondary Accessions:
    • B0S838
    • Q96CT5

    Protein attributes for GNL1 Gene

    607 amino acids
    Molecular mass:
    68661 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GNL1 Gene


neXtProt entry for GNL1 Gene

Proteomics data for GNL1 Gene at MOPED

Post-translational modifications for GNL1 Gene

  • Ubiquitination at Lys 158
  • Modification sites at PhosphoSitePlus

Other Protein References for GNL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GNL1 Gene

Domains & Families for GNL1 Gene

Protein Domains for GNL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
  • Belongs to the TRAFAC class YlqF/YawG GTPase family.
  • In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
  • Contains 1 CP-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class YlqF/YawG GTPase family.
genes like me logo Genes that share domains with GNL1: view

No data available for Gene Families for GNL1 Gene

Function for GNL1 Gene

Molecular function for GNL1 Gene

GENATLAS Biochemistry:
guanine nucleotide binding protein in MHC class I region,43kDa (see HLA-CAT@)
UniProtKB/Swiss-Prot Function:
Possible regulatory or functional link with the histocompatibility cluster.

Phenotypes for GNL1 Gene

GenomeRNAi human phenotypes for GNL1:
genes like me logo Genes that share phenotypes with GNL1: view

Animal Model Products

CRISPR Products

miRNA for GNL1 Gene

miRTarBase miRNAs that target GNL1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GNL1 Gene

Localization for GNL1 Gene

Subcellular locations from

Jensen Localization Image for GNL1 Gene COMPARTMENTS Subcellular localization image for GNL1 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GNL1 Gene

Pathways & Interactions for GNL1 Gene

SuperPathways for GNL1 Gene

No Data Available

Interacting Proteins for GNL1 Gene

Gene Ontology (GO) - Biological Process for GNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002456 T cell mediated immunity NAS 8180467
GO:0006974 cellular response to DNA damage stimulus IDA 17525332
GO:0042254 ribosome biogenesis IBA --
genes like me logo Genes that share ontologies with GNL1: view

No data available for Pathways by source and SIGNOR curated interactions for GNL1 Gene

Drugs & Compounds for GNL1 Gene

(3) Drugs for GNL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GNL1: view

Transcripts for GNL1 Gene

Unigene Clusters for GNL1 Gene

Guanine nucleotide binding protein-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNL1 Gene

No ASD Table

Relevant External Links for GNL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GNL1 Gene

mRNA expression in normal human tissues for GNL1 Gene

Protein differential expression in normal tissues from HIPED for GNL1 Gene

This gene is overexpressed in Lymph node (9.3), Peripheral blood mononuclear cells (9.1), and Frontal cortex (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNL1 Gene

SOURCE GeneReport for Unigene cluster for GNL1 Gene Hs.83147

genes like me logo Genes that share expression patterns with GNL1: view

Protein tissue co-expression partners for GNL1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GNL1 Gene

Orthologs for GNL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GNL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GNL1 35
  • 92.15 (n)
  • 98.02 (a)
GNL1 36
  • 98 (a)
(Canis familiaris)
Mammalia GNL1 35
  • 91.32 (n)
  • 97.69 (a)
GNL1 36
  • 98 (a)
(Mus musculus)
Mammalia Gnl1 35
  • 88.3 (n)
  • 95.39 (a)
Gnl1 16
Gnl1 36
  • 95 (a)
(Pan troglodytes)
Mammalia GNL1 35
  • 99.73 (n)
  • 99.67 (a)
GNL1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gnl1 35
  • 88.58 (n)
  • 95.72 (a)
(Monodelphis domestica)
Mammalia GNL1 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
-- 36
  • 76 (a)
(Gallus gallus)
Aves LOC101751100 35
  • 67.74 (n)
  • 70.97 (a)
GNL1 36
  • 63 (a)
(Anolis carolinensis)
Reptilia GNL1 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gnl1 35
  • 62.35 (n)
  • 65.45 (a)
(Danio rerio)
Actinopterygii gnl1 35
  • 60.54 (n)
  • 57.5 (a)
gnl1 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9320 37
  • 43 (a)
ns4 35
  • 51.91 (n)
  • 47.23 (a)
ns4 36
  • 40 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008330 35
  • 54.39 (n)
  • 50.11 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LSG1 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
Species with no ortholog for GNL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNL1 Gene

Gene Tree for GNL1 (if available)
Gene Tree for GNL1 (if available)

Paralogs for GNL1 Gene

Paralogs for GNL1 Gene

(1) SIMAP similar genes for GNL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GNL1: view

Variants for GNL1 Gene

Sequence variations from dbSNP and Humsavar for GNL1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1051139 -- 30,547,215(-) GGCTA(C/T)CTGGC reference, synonymous-codon
rs1058318 -- 30,544,386(-) AAAAT(A/G)TGGAG utr-variant-3-prime
rs5875262 -- 30,546,736(+) AGGCT(-/G)AGGCG reference, frameshift-variant
rs5875263 -- 30,548,996(+) TTTTT(-/T/TT)GTTTT intron-variant
rs6908888 -- 30,553,658(+) GCCCT(A/G)GTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GNL1 Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV Deletion 23290073
nsv884077 CNV Loss 21882294
nsv884086 CNV Gain 21882294
esv2670269 CNV Deletion 23128226
nsv884090 CNV Loss 21882294

Variation tolerance for GNL1 Gene

Residual Variation Intolerance Score: 22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.63% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GNL1 Gene

Disorders for GNL1 Gene

Relevant External Links for GNL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GNL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNL1 Gene

Publications for GNL1 Gene

  1. Structure and evolution of a member of a new subfamily of GTP-binding proteins mapping to the human MHC class I region. (PMID: 8180467) Vernet C. … Pontarotti P. (Mamm. Genome 1994) 2 3 4 67
  2. Subcellular distribution of the human putative nucleolar GTPase GNL1 is regulated by a novel arginine/lysine-rich domain and a GTP binding domain in a cell cycle-dependent manner. (PMID: 22244851) Boddapati N. … Mahalingam S. (J. Mol. Biol. 2012) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Single nucleotide polymorphisms at the PRR3, ABCF1, and GNL1 genes in the HLA class I region are associated with Graves' ophthalmopathy in a gender-dependent manner. (PMID: 24908204) Liu Y.H. … Tsai F.J. (Ophthalmology 2014) 3

Products for GNL1 Gene

Sources for GNL1 Gene