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Aliases for GNGT2 Gene

Aliases for GNGT2 Gene

  • Guanine Nucleotide Binding Protein (G Protein), Gamma Transducing Activity Polypeptide 2 2 3
  • Guanine Nucleotide Binding Protein Gamma Transducing Activity Polypeptide 2 3 4
  • G Gamma-C 3 4
  • G-GAMMA-8 3 4
  • G-Gamma-9 3 4
  • GNGT8 3 4
  • GNG8 3 4
  • GNG9 3 4
  • Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-T2 3
  • Guanine Nucleotide Binding Protein Gamma 9 3
  • G Protein Cone Gamma 8 Subunit 3
  • Gamma-T2 Subunit 3
  • G-GAMMA-C 3

External Ids for GNGT2 Gene

Previous GeneCards Identifiers for GNGT2 Gene

  • GC17M046994
  • GC17M049763
  • GC17M047626
  • GC17M047758
  • GC17M044638
  • GC17M047283
  • GC17M042649

Summaries for GNGT2 Gene

Entrez Gene Summary for GNGT2 Gene

  • Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for GNGT2 Gene

GNGT2 (Guanine Nucleotide Binding Protein (G Protein), Gamma Transducing Activity Polypeptide 2) is a Protein Coding gene. Diseases associated with GNGT2 include cll/sll. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include signal transducer activity and GTPase activity. An important paralog of this gene is GNG11.

UniProtKB/Swiss-Prot for GNGT2 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Tocris Summary for GNGT2 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; in addition, some Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNGT2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNGT2 Gene

Genomics for GNGT2 Gene

Regulatory Elements for GNGT2 Gene

Genomic Location for GNGT2 Gene

Start:
49,202,791 bp from pter
End:
49,210,574 bp from pter
Size:
7,784 bases
Orientation:
Minus strand

Genomic View for GNGT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNGT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNGT2 Gene

Proteins for GNGT2 Gene

  • Protein details for GNGT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14610-GBGT2_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
    Protein Accession:
    O14610
    Secondary Accessions:
    • B2R746
    • D3DTW5

    Protein attributes for GNGT2 Gene

    Size:
    69 amino acids
    Molecular mass:
    7747 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma

neXtProt entry for GNGT2 Gene

Proteomics data for GNGT2 Gene at MOPED

Post-translational modifications for GNGT2 Gene

No Post-translational modifications

Other Protein References for GNGT2 Gene

No data available for DME Specific Peptides for GNGT2 Gene

Domains for GNGT2 Gene

Protein Domains for GNGT2 Gene

Suggested Antigen Peptide Sequences for GNGT2 Gene

Graphical View of Domain Structure for InterPro Entry

O14610

UniProtKB/Swiss-Prot:

GBGT2_HUMAN :
  • O14610
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNGT2: view

No data available for Gene Families for GNGT2 Gene

Function for GNGT2 Gene

Molecular function for GNGT2 Gene

GENATLAS Biochemistry: guanine nucleotide binding protein (G protein) gamma subunit,retinal cone phosphoreceptor specific
UniProtKB/Swiss-Prot Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Gene Ontology (GO) - Molecular Function for GNGT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 9286705
GO:0004871 signal transducer activity NAS 9286705
genes like me logo Genes that share ontologies with GNGT2: view

Animal Model Products

CRISPR Products

miRNA for GNGT2 Gene

miRTarBase miRNAs that target GNGT2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNGT2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GNGT2 Gene

Localization for GNGT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNGT2 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNGT2 Gene COMPARTMENTS Subcellular localization image for GNGT2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for GNGT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex NAS 9286705
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GNGT2: view

Pathways for GNGT2 Gene

SuperPathways for GNGT2 Gene

Superpath Contained pathways
1 ADP signalling through P2Y purinoceptor 12
2 Development Angiotensin activation of ERK
3 Circadian entrainment
4 G-Beta Gamma Signaling
5 ERK Signaling
genes like me logo Genes that share pathways with GNGT2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GNGT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007186 G-protein coupled receptor signaling pathway NAS 9286705
GO:0007268 synaptic transmission TAS --
GO:0007602 phototransduction NAS 9286705
GO:0008152 metabolic process NAS 9286705
genes like me logo Genes that share ontologies with GNGT2: view

Compounds for GNGT2 Gene

(5) Tocris Compounds for GNGT2 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG [51116-01-9]
CCG 50014 Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein [883050-24-6]
Gallein Inhibitor of betagamma signaling [2103-64-2]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors [265980-25-4]

(3) HMDB Compounds for GNGT2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with GNGT2: view

Transcripts for GNGT2 Gene

Unigene Clusters for GNGT2 Gene

Guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GNGT2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for GNGT2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GNGT2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - -
SP3: -
SP4:
SP5:

Relevant External Links for GNGT2 Gene

GeneLoc Exon Structure for
GNGT2
ECgene alternative splicing isoforms for
GNGT2

Expression for GNGT2 Gene

mRNA expression in normal human tissues for GNGT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GNGT2 Gene

This gene is overexpressed in Whole Blood (7.3) and Spleen (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GNGT2 Gene

SOURCE GeneReport for Unigene cluster for GNGT2 Gene Hs.181781

mRNA Expression by UniProt/SwissProt for GNGT2 Gene

O14610-GBGT2_HUMAN
Tissue specificity: Retinal cones
genes like me logo Genes that share expressions with GNGT2: view

In Situ Assay Products

Orthologs for GNGT2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNGT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNGT2 35
  • 100 (n)
  • 100 (a)
GNGT2 36
  • 73 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNGT2 35
  • 87.44 (n)
  • 85.51 (a)
GNGT2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNGT2 35
  • 87.92 (n)
  • 85.51 (a)
GNGT2 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gngt2 35
  • 85.02 (n)
  • 82.61 (a)
Gngt2 16
Gngt2 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNGT2 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gngt2 35
  • 84.54 (n)
  • 84.06 (a)
chicken
(Gallus gallus)
Aves GNGT2 36
  • 72 (a)
OneToOne
LOC100859179 35
  • 74.4 (n)
  • 73.91 (a)
lizard
(Anolis carolinensis)
Reptilia GNGT2 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gngt2.1 35
  • 68.6 (n)
  • 71.01 (a)
zebrafish
(Danio rerio)
Actinopterygii gngt2 35
gngt2a 35
  • 70.05 (n)
  • 69.57 (a)
gngt2a 36
  • 70 (a)
OneToMany
gngt2b 36
  • 55 (a)
OneToMany
Species with no ortholog for GNGT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNGT2 Gene

ENSEMBL:
Gene Tree for GNGT2 (if available)
TreeFam:
Gene Tree for GNGT2 (if available)

Paralogs for GNGT2 Gene

Paralogs for GNGT2 Gene

Selected SIMAP similar genes for GNGT2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GNGT2: view

Variants for GNGT2 Gene

Sequence variations from dbSNP and Humsavar for GNGT2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2293215 -- 49,207,321(-) GCCCC(A/G)TCCCT intron-variant
rs3830594 -- 49,207,313(-) CCTGC(-/T)TCTTC intron-variant
rs4793611 -- 49,205,986(+) TCCAG(A/C)CCCCA downstream-variant-500B
rs4793612 -- 49,206,137(+) CTAAA(C/T)TCCAT downstream-variant-500B
rs9895097 - 49,207,390(+) ATCTT(A/C)AACAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GNGT2 Gene

Variant ID Type Subtype PubMed ID
nsv2074 CNV Insertion 18451855

Relevant External Links for GNGT2 Gene

HapMap Linkage Disequilibrium report
GNGT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNGT2 Gene

Disorders for GNGT2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for GNGT2 Gene including...

Search for GNGT2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for GNGT2 Gene

genes like me logo Genes that share disorders with GNGT2: view

No data available for UniProtKB/Swiss-Prot for GNGT2 Gene

Publications for GNGT2 Gene

  1. Gene structure and chromosome localization of the G gamma c subunit of human cone G-protein (GNGT2). (PMID: 9286705) Ong O.C. … Fung B.K.-K. (Genomics 1997) 2 3 4 23
  2. Identification of a region in G protein gamma subunits conserved across species but hypervariable among subunit isoforms. (PMID: 11714923) Cook L.A. … Hildebrandt J.D. (Protein Sci. 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. The molecular basis for T-type Ca2+ channel inhibition by G protein beta2gamma2 subunits. (PMID: 16973746) DePuy S.D. … Barrett P.Q. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3

Products for GNGT2 Gene

Sources for GNGT2 Gene

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